LOCUS       CP002160                9389 bp    DNA     linear   BCT 08-JAN-2014
DEFINITION  Clostridium cellulovorans 743B, complete genome.
ACCESSION   CP002160
VERSION     CP002160.1
DBLINK      BioProject: PRJNA32609
            BioSample: SAMN00002614
KEYWORDS    GSC:MIGS:2.1.
SOURCE      Clostridium cellulovorans 743B
  ORGANISM  Clostridium cellulovorans 743B
            Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
            Clostridium.
REFERENCE   1  (bases 1 to 9389)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Bruce,D.,
            Goodwin,L., Pitluck,S., Chertkov,O., Detter,J.C., Han,C., Tapia,R.,
            Land,M., Hauser,L., Chang,Y.-J., Jeffries,C., Kyrpides,N.,
            Ivanova,N., Mikhailova,N., Hemme,C.L. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of Clostridium cellulovorans 743B
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9389)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Bruce,D.,
            Goodwin,L., Pitluck,S., Chertkov,O., Detter,J.C., Han,C., Tapia,R.,
            Land,M., Hauser,L., Chang,Y.-J., Jeffries,C., Kyrpides,N.,
            Ivanova,N., Mikhailova,N., Hemme,C.L. and Woyke,T.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2010) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type       :: bacteria_archaea
            project_name :: Clostridium cellulovorans 743B, ATCC 35296
            collection_date          :: Missing
            lat_lon                  :: Missing
            depth                    :: Missing
            alt_elev                 :: Missing
            country                  :: Missing
            environment              :: Soil
            num_replicons            :: 1
            ref_biomaterial          :: ATCC 35296
            biotic_relationship      :: Free living
            trophic_level            :: Chemoorganotroph
            rel_to_oxygen            :: Anaerobe
            isol_growth_condt        :: Missing
            sequencing_meth          :: WGS
            assembly                 :: Newbler v. 2.3 (pre-release)
            finishing_strategy       :: Finished
            Sequencing Depth         :: 30x
            GOLD Stamp ID            :: Gi02570
            Type Strain              :: Yes
            Greengenes ID            :: 16224
            Gene Calling Method      :: Prodigal
            Isolation Site           :: cellulose digester
            Source of Isolate        :: ATCC 35296
            Cell Shape               :: Rod-shaped
            Motility                 :: Nonmotile
            Sporulation              :: Sporulating
            Temperature Range        :: Mesophile
            Gram Staining            :: Gram-
            Diseases                 :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal           :: Finished
            Current Finishing Status :: Finished
            Assembly Method          :: Newbler v. 2.3
            Genome Coverage          :: 30x
            Sequencing Technology    :: 454/Illumina
            ##Genome-Assembly-Data-END##
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4085037
            Source DNA and organism available from Christopher L. Hemme
            (hemmecl@ou.edu)
            Contacts: Christopher L. Hemme (hemmecl@ou.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. it is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
FEATURES             Location/Qualifiers
     source          1..9389
                     /organism="Clostridium cellulovorans 743B"
                     /mol_type="genomic DNA"
                     /strain="743B"
                     /type_material="type strain of Clostridium cellulovorans"
                     /db_xref="taxon:573061"
     gene            complement(1..810)
                     /locus_tag="Clocel_2592"
     CDS             complement(1..810)
                     /locus_tag="Clocel_2592"
                     /inference="protein motif:PFAM:PF00072"
                     /note="KEGG: cbe:Cbei_4962 response regulator receiver
                     protein; PFAM: response regulator receiver;
                     helix-turn-helix- domain containing protein AraC type;
                     SMART: response regulator receiver; Helix-turn-helix, AraC
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_AraC,DBD-Pfam|HTH_AraC,DBD-SUPERFAMI
                     LY|0035607,DBD-SUPERFAMILY|0035607"
                     /protein_id="ADL52302.1"
                     /db_xref="GO:0000156"
                     /db_xref="GO:0003700"
                     /db_xref="GO:0043565"
                     /db_xref="InterPro:IPR000005"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR018060"
                     /translation="MNNVIQMITVDDEYLIRNLIKNCIDWNKIGVEIIGEASNSEEAIE
                     IIKENQPDIVLTDICMPSTDGLDMSNYILDKYPNIKVVVITGYDEFEYAKRAIKVGVSD
                     FILKPINDDELKKTVLKLKESILNERLKEKDYRQAKDRLSTFGDIVNLNENEKYEDKAL
                     NIEDVKKFILKNISNVDLSLKFVSEHFYVNSSYLSRIFKLKTGNNFSEYVTNVRMKIAM
                     DMLKNSDAKSSEIARKIGIDDPNYFSTCFKKYTGSSIKEFKKTLIKS"
     gene            complement(814..2610)
                     /locus_tag="Clocel_2593"
     CDS             complement(814..2610)
                     /locus_tag="Clocel_2593"
                     /inference="protein motif:PFAM:PF06580"
                     /note="KEGG: cbe:Cbei_4963 integral membrane sensor signal
                     transduction histidine kinase; PFAM: histidine kinase
                     internal region; histidine kinase HAMP region domain
                     protein; ATP-binding region ATPase domain protein; SMART:
                     ATP-binding region ATPase domain protein; histidine kinase
                     HAMP region domain protein"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|dCache_1,STP|HATPase_c"
                     /protein_id="ADL52303.1"
                     /db_xref="GO:0000155"
                     /db_xref="GO:0004871"
                     /db_xref="GO:0005524"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR005467"
                     /db_xref="InterPro:IPR010559"
                     /translation="MICRLNIFKLRDIFTSLKNKYLNLKISLKIIIYFSVIFIIATLVL
                     NFTYGKINRTYMTEKIKQGSFEALESTKASINLIIDNVSNASKMIVSSDDVQNSLKNTN
                     LKSDLEAQNNINKYLSQFTNFNPYIASIYILDNYSNKYYSENNTYKSFTVDQIRNMEWY
                     NEVLNENGGYILKLNGGGLFHNKTGNYESYVSFIRIINDINTQEKVGVLIININENAFY
                     DYIVKVSNQYGTKLIIENENGEVITKPDIEENILKVAENEKYSAKNKGFVIKNLNYKDY
                     IISNIKMEKYDWNLISISEYSQLSEQSKYTKNFMVVFISISLLLIVFGAIGISNMITKP
                     LTKLHKSMKDVKNGEFKIVEGKTYNDEVGELKKVYNIMVQNIQFLLDKIREDELFKRKA
                     ELDLLMSQIKPHFLYNTFDSISSLALSGENKRVYQIVKALGTFYRTSLSNGRDVITIEE
                     EINTIKSYLVIQNIRYNDKFDVQYNLDPNCNEFKIIKLVLQPLVENSIYHGLRSKVEKG
                     MIKISTYEEGEKIVLSVEDNGCGIDESKIKELMDGRTSGIGVRATKERLRVFYGAKSEF
                     IIKSEKDVGTKIIIKIHKKEVN"
     gene            complement(2621..3889)
                     /locus_tag="Clocel_2594"
     CDS             complement(2621..3889)
                     /locus_tag="Clocel_2594"
                     /inference="protein motif:PFAM:PF01547"
                     /note="PFAM: extracellular solute-binding protein family 1;
                     KEGG: cbe:Cbei_4964 extracellular solute-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|SBP_bac_1"
                     /protein_id="ADL52304.1"
                     /db_xref="GO:0005215"
                     /db_xref="InterPro:IPR006059"
                     /translation="MKKLISVFLILLFFLSLQGCYKNTENNFSKSQKITLKMWHIWAQR
                     SQDNNSIIIGDIINQWNKNNPNVQIEVESVENEKYKTKLKTAFATNELPDIFYSWGGNF
                     SKPLIDSGKVLAINEYLDNSVMDELNEGMLSNVTYYDKIYGLPLTFSVGTFYINTQLFE
                     EANIKIPDNYDEFLDVVKAFRQKGITPLLVGEQDKWTGTLYYDILALRDGGIEGCKSAL
                     SGNDKSNIYLNAANRLKELIDIEAFDESNIRAMRDESEVFFKQGKVAMYFTGNWLTGEI
                     QAETSLIKDKIMVKTFPIMTDGKGNNNEFLGGAVDYLMVSTNSPYKDEAVQAIKFICKN
                     LSKNYYEFGSGLPAWKYDYDETNVNKLSKELRKMTENGKYLLYWDIYLGEEKGNKHKEL
                     VYKLFQKKISSEEFAEEMKKLEE"
     gene            complement(4123..5709)
                     /locus_tag="Clocel_2595"
     CDS             complement(4123..5709)
                     /locus_tag="Clocel_2595"
                     /EC_number="3.2.1.37"
                     /inference="protein motif:PRIAM:3.2.1.37"
                     /note="KEGG: cbe:Cbei_4126 alpha-N-arabinofuranosidase;
                     PFAM: glycoside hydrolase family 43"
                     /codon_start=1
                     /transl_table=11
                     /product="GH43|GH43_11"
                     /protein_id="ADL52305.1"
                     /db_xref="InterPro:IPR006710"
                     /translation="MNKIKNPILKGFNPDPSICRVGEDYYIATSTFEWFPGVQIHHSKD
                     LKNWNLIKRPLDRLSQLNMIGNPDSGGIWAPCLTYSDNLFWLIYTDVKHLSGAWKDSLN
                     YLVTCDTITGDWSEPIFLNSTGFDPSLYHDDDGKKYLLNMVWDHREVNHPFYGIMIQEY
                     SHEEKKLIGKSKVIFKGTEIKLTEGPHIYKINGYYYLMVAEGGTKYEHAVTVARSKNIM
                     GPYELHPENPILTSWNSPTNPLQKAGHASLVHTHTDEWYLAHLVGRPLTERGCCPLGRE
                     TAIQKIEWKNGWPYVANGNEPSLYVEAPQMEEVKWEKSYPERDDFEEDQLNINFQTLRV
                     PLDESVMTLKERKGYLRLRGKQSLTSKFLQAHVSRRWQSFNFDAITGLQFNPTSFQQMA
                     GLVCYYNTENWVYINVTHDEEVGKIINLIECDNFKFTEPLKYKKIVVPEDLETVHFKVE
                     VRRENYRFLYSFDEKLWVEIPITFDSNKLSDDYIRGEGFFTGAFVGICCQDATGTGIAA
                     DFDYFTYKEIY"
     gene            complement(5781..6806)
                     /locus_tag="Clocel_2596"
     CDS             complement(5781..6806)
                     /locus_tag="Clocel_2596"
                     /inference="similar to AA sequence:KEGG:Cbei_4966"
                     /note="KEGG: cbe:Cbei_4966 ABC-type sugar transport system
                     periplasmic component-like protein"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A6VKT0|3.A.1.2.13"
                     /protein_id="ADL52306.1"
                     /translation="MKKRIIAIISVVLITGSIFAGCGQKAETKGDSSSNSKTLYFVPIV
                     DTGAYWSPMKKAAQDEANALGYDLVFKTSPSNESQKNEKHLGFLDEAIQNDAAGIAVSP
                     MDPDMFDKKVKEIKDEDIPVVTFDADVKTKDNRTAYVGTDNKLAGEELGKQAGEYLKSK
                     GIKTGKIALAAVNLTQTTMTYRQEGIKKGFEKAMGSDAANFTWLEPIQDNDQAAESKKQ
                     LEGQITANQDMVAVFSLGSEGPDTGVMEAIKSQNKAGKIYHFGFDYTPTWENGVESGLI
                     TGIVDQDSYAIGKTVIDVLDKQIKGEKIDDNYPVPVKWIPADQIVEYGKEKQKQFTTET
                     K"
     sig_peptide     complement(6729..6806)
                     /locus_tag="Clocel_2596"
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.919) with cleavage site probability 0.505 at
                     residue 26"
     gene            complement(6862..7893)
                     /locus_tag="Clocel_2597"
     CDS             complement(6862..7893)
                     /locus_tag="Clocel_2597"
                     /inference="protein motif:PFAM:PF02653"
                     /note="PFAM: inner-membrane translocator; KEGG:
                     cbe:Cbei_4967 monosaccharide-transporting ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A6VKS9|3.A.1.2.13"
                     /protein_id="ADL52307.1"
                     /db_xref="GO:0005215"
                     /db_xref="InterPro:IPR001851"
                     /translation="MNQNIDNKSNVFVKKSKKLFVENLNKLNPKELFMKYSIFLVLIVL
                     IVVFSGLSPKFLGSANIGNFLRQIPTVGIFTVAITMIMITGGVDLSIGAIAAFSGTIAA
                     YMSVQGFNPVIVIAACLAIGALWGMFNGALISKFKLEPFILTLGTSYLIRGLILFLTNG
                     IYIKGVPDWFYNISNTTIGTKLVHSNTVIFILIVILMAFVMKNTRFGRYCYAVGSNKEA
                     ARLSGINVNKHFIKVFALEGSLAALAGLLLMSNLNVGAPSEASGIDLFAMAAAIIGGAQ
                     FGGGIGTIGGAIVGILTIQVFQSGLAIMGVNTFIQQAVTGGIIAVAVIVDFYRKNSTLK
                     IKI"
     gene            complement(7896..9389)
                     /locus_tag="Clocel_2598"
     CDS             complement(7896..9389)
                     /locus_tag="Clocel_2598"
                     /inference="protein motif:PFAM:PF00005"
                     /note="KEGG: cbe:Cbei_4968 ABC transporter related; PFAM:
                     ABC transporter related; SMART: AAA ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|G4FGN3|3.A.1.2.20"
                     /protein_id="ADL52308.1"
                     /db_xref="GO:0005524"
                     /db_xref="GO:0016887"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR017871"
                     /translation="MSKVFLKMENIHKKFPGVYALKGAGLEVRKGEVHGLLGENGAGKS
                     TLMKILGGVHKQDEGKIYVEDKECGFINPSKAAELGIGFVHQELNLSEALTVAENVFMG
                     RLPYKNKALGIVDYKKLYSDTDIIIKRLGIDIKPTDLISDLETAKKQMVEIAKTISLNA
                     NIIIFDEPTTSLSNKDVASLFEVINHLKSQGVAVIYISHRLKEIFEICDRATVLRDGTL
                     IGSCNIKEISQEVLINMMVGRELKNLFPKEFFKPGEVVLEINGLGDVSGRIKDINIKAR
                     KGEILGFAGLVGSGRTEVMRLIFGADKIGKGEIKVNGKKVKIKSPEDAISNGICLLTED
                     RKKQGLSLVMSVNDNINITNLNNSLLNHKVLKETGDKFREALLIKTANLDVMAGTLSGG
                     NQQKIVLAKWLNTNSEVFIFDEPTKGIDVGAKAEIYHIMNDLIRKNKVVIMISSELPEL
                     LGMSDRIYVMCEGRITGELNRQEASQEKIMALATVGGAN"
ORIGIN
        1 ctatgattta atcaatgttt tcttaaattc ttttatagaa ctaccagtat actttttaaa
       61 acaagtacta aagtaatttg gatcatctat acctattttt ctagctattt cacttgattt
      121 cgcatctgag tttttaagca tatccatagc aattttcatc cttacattag taacatactc
      181 tgaaaaatta ttgccagttt ttaatttaaa tatcctgctt aaatagcttg aattaacata
      241 aaaatgttct gatacaaatt ttaatgataa atcaacattg gatatattct ttaatataaa
      301 tttctttaca tcttcgatat ttaatgcttt atcttcatat ttttcatttt catttaaatt
      361 cacaatatcc ccaaaggtac ttagtctatc tttagcttgt ctataatcct tttcctttaa
      421 tctttcattt aatatgctct ctttcaattt taaaactgtt ttttttaatt catcgtcatt
      481 tataggttta agtataaagt cacttactcc aacctttata gctcttttag catattcaaa
      541 ctcatcatag ccagttatta caacaacttt aatattggga tacttatcta aaatataatt
      601 actcatatct agtccatcag ttgaaggcat acatatatca gttaaaacaa tatctggttg
      661 attttctttt attatttcta tagcttcttc tgaattagaa gcttctccta ttatctcaac
      721 accaattttg ttccagtcta tgcaattttt tattagattt ctaattaaat attcatcatc
      781 gactgtaatc atctgtatca cattattcat tagttaattc acttcctttt tatgaatttt
      841 aattattatt ttagttccaa catctttttc acttttaata ataaattcgc tcttagcacc
      901 ataaaatact cttagccttt cttttgtagc tctaactccg atcccagaag ttctgccgtc
      961 cataagctct ttaatttttg attcatctat tccacagcca ttatcttcaa cactcagtac
     1021 aatcttctcc ccttcttcat aggtagaaat ttttatcatt cccttttcta ctttacttct
     1081 aagcccatga taaatagagt tttctaccaa aggttgtaac actaacttta ttattttaaa
     1141 ttcattgcag tttggatcta agttatattg gacgtcaaac ttatcattat atcttatatt
     1201 ttggattacc aaataactct ttatagtatt tatctcttct tcaattgtta ttacatctcg
     1261 cccattgctc aaacttgttc tataaaatgt tcctaaagct tttacaatct gatataccct
     1321 tttattttcc cctgataatg ctagggaact tatggaatcg aaagtattat ataaaaaatg
     1381 aggttttatt tgtgacatca acaaatctaa ttctgccttc cttttaaaca actcatcttc
     1441 tcttatttta tctaagagga actgaatatt ttgaaccata atattatata ctttcttcag
     1501 ttctccaact tcatcattgt aggtttttcc ctcaacaatt ttaaactctc cattttttac
     1561 atctttcatt gacttatgaa gttttgttaa aggctttgta atcatgtttg atattccaat
     1621 tgcgccaaag acaataagta aaagactaat gcttataaaa actaccataa aattttttgt
     1681 atattttgat tgttcactta attgactata ttcactgata ctaattaaat tccaatcata
     1741 cttttccatt tttatatttg atataatgta atctttgtaa ttcaaatttt taataacaaa
     1801 gcctttattt ttagcagaat atttttcatt ttctgccact tttaatatat tttcttctat
     1861 atcgggcttt gttataactt caccattttc attttctata attaatttgg tgccatattg
     1921 attgcttacc tttacaatat aatcgtagaa ggcattttca ttaatattta taattaatac
     1981 tcctaccttt tcttgagtat taatatcatt tattattctt ataaaagaga catatgattc
     2041 ataattaccc gtcttattat gaaacaatcc ccctccattt agctttaaga tataaccacc
     2101 attttcattt aaaacttcgt tataccactc catatttcta atttgatcaa ctgtaaagct
     2161 tttataagta ttattttcag agtaatattt attgctgtaa ttatctaata tatatataga
     2221 tgcaatatat gggttgaaat ttgtaaactg agagagatat ttattaatat tattttgagc
     2281 ctctaaatca gacttaagat tagtgttttt taaactattt tggacatcat cactagatac
     2341 gatcattttc gaagcattag aaacattatc aattattagg tttatacttg cttttgtact
     2401 ttctaaagct tcgaaggaac cttgctttat tttttccgtc atataagttc tattaatttt
     2461 cccataggta aagttaagta ctaaagttgc tattataaaa attactgaaa aatatataat
     2521 tatctttaaa cttattttta aatttaagta tttatttttt aagctagtaa atatatctct
     2581 taatttaaaa atatttaatc tacaaatcat agttttaatt ttattcctcc aactttttca
     2641 tttcttcagc aaattcctca gaacttatct ttttctggaa taacttatag actagctcct
     2701 tgtgcttatt tcctttttct tcacctaagt atatatccca atataaaagg tattttccat
     2761 tctcagtcat ctttcttaat tccttagaaa gtttatttac atttgtttca tcataatcgt
     2821 atttccaagc aggcaaacct gaaccaaact catagtaatt tttcgagaga tttttacata
     2881 taaattttat agcctgaaca gcttcatctt tatatggtga gttggtgctt accattaaat
     2941 agtcaacagc tccacctaaa aactcattat tatttccttt accatctgtc attataggaa
     3001 aagttttaac cataatttta tcttttatta aagaagtttc cgcttgtatt tctcctgtga
     3061 gccaatttcc tgtaaaatac attgctactt ttccttgttt aaaaaacact tccgactcat
     3121 ctctcatagc ccttatgttt gactcatcaa atgcctctat atctataagt tcctttaatc
     3181 gattagctgc atttaaatat atattacttt tatcattacc tgaaagtgca ctcttacaac
     3241 cttctattcc tccatctcta agagctaaaa tatcataata taaagtacca gtccatttat
     3301 cttgctcacc aactaatagt ggagttatac ctttttgtct aaaagccttt acaacatcta
     3361 gaaattcatc gtagttgtct ggtattttaa tgtttgcttc ttcaaacaat tgagtattta
     3421 tataaaatgt acctacagaa aaagtaagag gaagtccata tattttatca taataagtta
     3481 cattgcttaa cataccctca ttaagttcat ccattacact attatctaaa tattcattaa
     3541 tagctagcac tttccccgaa tctattaatg gtttagaaaa attcccaccc catgaataaa
     3601 atatatctgg taattcatta gtagcaaagg cagtctttaa ttttgtttta tatttttcat
     3661 tttcaacgct ttcaacctca atttgaacat taggattatt tttattccac tgatttataa
     3721 tgtctccaat aataattgaa ttattatcct gagatctttg tgcccatata tgccacatct
     3781 taagtgttat tttttgactt ttactgaaat tgttttcagt gtttttatag cacccttgaa
     3841 gacttaaaaa aaataataat attaaaaaca ctgaaattaa ctttttcatg caatcacctc
     3901 aaagataata taatggtttt taactaactt tatttatata gtaaaacatt atatataaat
     3961 tattcattat agatattaaa tattaaatat taaatattta atttattaac gatctagttc
     4021 aaatttaaat tggatttttc ttatctttgt tcacttagta aaaacttaaa tatgactaaa
     4081 ggcaaggatt ttaaatataa aaattccctg ccaagtgtca agttagtaaa tctctttata
     4141 agtaaaataa tcaaagtcag cagctatacc tgtacctgtt gcatcttgac agcaaattcc
     4201 aacaaatgca cccgtgaaga atccttctcc tctgatatag tcatcagata gcttatttga
     4261 atcaaaagtt ataggaatct caacccataa tttttcatca aaggaatata agaatctata
     4321 gttctctctt ctaacttcca ctttaaaatg aactgtctct aaatcttctg gaaccactat
     4381 ttttttatat ttaagcggct cagtaaattt aaaattatca cattcaatta agttgataat
     4441 tttcccaact tcttcatcat gggtaacatt aatatatacc caattttcag tattataata
     4501 gcatactagc ccagccattt gttgaaaact agtaggatta aattgtaaac ctgttattgc
     4561 atcaaaatta aaactttgcc atcttcttga aacatgagct tgtaggaatt ttgaagttaa
     4621 agattgtttt ccacgaagtc ttaagtatcc ttttctttcc ttcaacgtca tcactgattc
     4681 atctaaagga actcttaacg tctgaaagtt aatatttaat tgatcttctt caaaatcatc
     4741 tctttcagga tagctcttct cccatttaac ttcctccatt tgtggcgctt caacatataa
     4801 tgaaggttca ttaccattag ctacatatgg ccaaccattc ttccattcaa tcttttgaat
     4861 agctgtttct ctacctaatg gacaacatcc tctttcagtt aaaggtctgc ctactaaatg
     4921 tgctaaatac cattcatctg tatgggtatg aactaaggag gcatgtccag ctttttgtaa
     4981 tggattagtt ggactattcc aagatgtcaa aattggattt tctggatgaa gttcatatgg
     5041 tcccataata ttcttagatc ttgcaactgt aactgcatgc tcatatttag ttccaccttc
     5101 tgcaaccatt aaataataat aaccatttat tttataaata tgaggtcctt cagtaagctt
     5161 tatttctgta cctttgaaaa taacttttga tttcccaatg agttttttct cttcgtgact
     5221 atattcttga atcattatcc cataaaacgg atgatttact tctctatgat cccataccat
     5281 gtttaataaa tatttcttac catcatcatc atgatacaag gatggatcaa aacctgtact
     5341 atttagaaaa ataggttcac tccaatctcc tgtaatagta tcacaagtta ctaaataatt
     5401 taaactatct ttccatgctc ctgataaatg cttaacatca gtatatatta accaaaacag
     5461 attatccgaa tacgttagac aaggtgccca aattccgcct gaatcaggat taccaatcat
     5521 atttaattgg ctcaatcgat ccaaaggtct ttttattaag ttccaatttt ttaaatcctt
     5581 tgagtgatgt atttgtactc ctggaaacca ttcaaaggtt gatgttgcaa tataataatc
     5641 ttctccaact ctacatatag atgggtctgg attaaagcct ttcaagatag gatttttgat
     5701 tttattcatt atattgtttt cctcctaact ttgtaaaata aagaggagtt taaggaaaac
     5761 tcctctgata ttacaaatta ttattttgtt tcagttgtaa actgtttttg cttttctttt
     5821 ccgtactcaa ctatttgatc tgctggtatc cattttactg gtactgggta gttgtcgtca
     5881 attttctccc ctttgatctg cttatctaat acatcgatta cagtcttacc gatagcataa
     5941 gaatcttggt caactatacc tgtaattaac ccactttcta caccattttc ccatgttgga
     6001 gtatagtcaa aaccaaaatg atatatttta ccagctttgt tttgagattt aatagcttcc
     6061 attacacctg tatcaggacc ttcagatcct aatgagaata cagcaaccat atcttgattt
     6121 gcagtaattt gtccttctaa ttgcttttta gactctgctg cttgatcatt atcttgtatt
     6181 ggttctaacc atgtaaagtt agcagcatca ctgcccatag ctttttcaaa gcctttcttt
     6241 ataccttctt gtctataagt catagtagtt tgagttaaat ttactgcagc taaagcaatt
     6301 ttacctgttt taattccttt agattttaaa tattcacctg cttgtttacc aagttcttct
     6361 cctgccaatt tattatcagt tcctacataa gcagttctat tatccttggt ttttacatca
     6421 gcatcaaaag ttacaactgg aatatcttca tcttttattt ctttaacctt cttatcaaac
     6481 atatctggat ccattggtga aactgctatt cctgcagcat cattttgtat agcttcatct
     6541 aagaaaccta aatgcttttc attcttttga gactcatttg aaggtgaagt tttgaatact
     6601 aaatcatagc ctaacgcatt agcttcatct tgagctgctt ttttcattgg cgaccaatat
     6661 gctcctgtat caactattgg cacaaaataa agtgttttgc tattacttga tgaatctcct
     6721 tttgtttccg ccttttgccc acatcctgca aatatacttc ctgttattaa cacaactgag
     6781 ataattgcaa taattctttt tttcattata aagtcctcct acaattttaa atatataaat
     6841 tctaactaat tatttaacta attaaatttt tatctttaat gtgctgttct tcctgtaaaa
     6901 atctacaatt acagcaactg ctataattcc tccagtaaca gcttgttgta taaatgtatt
     6961 tacacccata atggcaagtc cactttggaa aacttgtatt gtaagtatac ctactatagc
     7021 tccgcctata gtacctatgc cgcccccgaa ctgtgctcct ccaataattg ccgcagccat
     7081 agcaaataaa tctataccac ttgcttcact tggcgctcca acatttaagt tcgacatcaa
     7141 taatagacct gcaagtgcag ctaaacttcc ttctagcgca aatactttta taaagtgttt
     7201 atttacattt attccagata atcttgctgc ttctttattt gaacctacag cataacaata
     7261 acgtccaaat cttgtgtttt tcatcacaaa tgccattagt ataactatta aaataaatat
     7321 tacggtgtta gaatgtacta actttgttcc aatagttgtg tttgaaatat tataaaacca
     7381 atctggaacc cctttaatat aaattccatt tgtaaggaat aatattaatc ctcttataag
     7441 atagcttgta cccaaggtaa gtataaatgg ttctaattta aactttgaaa ttaatgctcc
     7501 attaaacata ccccataaag cacctattgc taaacatgct gctataacaa taactggatt
     7561 aaatccttgt acagacatat aagctgctat tgttcctgaa aaagctgcta ttgctccgat
     7621 agaaaggtca actcctccag taatcataat cattgtaata gcaaccgtga aaattccaac
     7681 agtaggtatt tgtcttaaaa agttacctat atttgcacta cctaaaaatt tagggctaag
     7741 tcctgaaaag actactatta aaacaataag cactaagaaa attgagtact tcataaataa
     7801 ttctttagga tttaatttat ttaaattttc aacgaacaat ttttttgatt ttttaacaaa
     7861 tacatttgat ttattatcta tattttgatt catttttaat tagcacctcc aacagtagct
     7921 aatgccatta ttttttcttg gctagcttct tgtctattaa gttctcctgt tatcctacct
     7981 tcacacataa catatattct gtcagacata cctaaaagtt caggaagttc tgaggatatc
     8041 ataattacaa ctttattttt tcttatcaaa tcgttcatga tatgatatat ttcagctttg
     8101 gcccctacat ctatcccctt agtaggttca tcaaaaataa acacctctga atttgtgttt
     8161 aaccatttag ctaatactat tttttgctga tttcctccgg aaagagttcc agccataaca
     8221 tcaagattag ctgtcttaat aagtaaagct tccctaaatt tatctccagt ttcttttaaa
     8281 actttgtgat ttaataaaga gttgtttaaa ttggtaatgt tgatattatc atttacactc
     8341 ataaccaaag ataaaccttg tttttttcta tcttctgtta aaagacatat accattgctt
     8401 attgcatctt ctggagattt tatttttacc tttttgccat ttacttttat ttctccctta
     8461 ccaatcttat cagctccaaa gattaacctc ataacctccg ttctacctga tccgactagc
     8521 ccagcaaatc ctaaaatctc ccctttcctt gctttaatat taatatcttt aattcttcca
     8581 ctgacatcac ctaaaccatt tatttccaaa actacttctc ctggtttaaa gaactccttc
     8641 ggaaataaat tttttaattc cctcccaacc atcatattta tcagcacttc ttgacttatc
     8701 tccttaatat tgcagctacc aataagagta ccgtctctta aaactgttgc tctatcacaa
     8761 atttcaaaaa tttctttcaa tctatgggat atataaataa ctgctacccc ttgagatttc
     8821 aggtgattta taacctcaaa caaactagca acatctttat ttgagagtga cgttgttggt
     8881 tcatcgaaaa taattatatt cgcattcaaa cttattgttt tagcaatctc aaccatttgt
     8941 tttttggctg tctctaaatc tgaaattaaa tctgtaggtt taatatctat ccctaatctc
     9001 ttgattatta tatccgtgtc ggaatataat tttttgtaat caacaattcc caatgctttg
     9061 tttttatatg gtaacctacc cataaacaca ttctctgcaa cagttaaagc ttctgataaa
     9121 tttaattcct gatgaacaaa tccaattcct agttctgcag ccttactcgg attaatgaag
     9181 ccacattcct tatcttcaac gtaaattttt ccttcgtctt gtttatgaac tcctccaagt
     9241 attttcatta aagttgattt tcctgcacca ttttcaccta aaagtccatg cacctctcct
     9301 tttctaactt ctaaccctgc accttttaat gcataaaccc ctggaaattt cttgtgtata
     9361 ttttccatct ttaagaacac tttactcac
//
