LOCUS       CP001840               12340 bp    DNA     linear   BCT 31-JAN-2014
DEFINITION  Bifidobacterium bifidum PRL2010, complete genome.
ACCESSION   CP001840
VERSION     CP001840.1
DBLINK      BioProject: PRJNA42863
            BioSample: SAMN02603510
KEYWORDS    .
SOURCE      Bifidobacterium bifidum PRL2010
  ORGANISM  Bifidobacterium bifidum PRL2010
            Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
            Bifidobacterium.
REFERENCE   1  (bases 1 to 12340)
  AUTHORS   Turroni,F., Bottacini,F., Foroni,E., Mulder,I., Kim,J.H., Zomer,A.,
            Sanchez,B., Bidossi,A., Ferrarini,A., Giubellini,V., Delledonne,M.,
            Henrissat,B., Coutinho,P., Oggioni,M., Fitzgerald,G.F., Mills,D.,
            Margolles,A., Kelly,D., van Sinderen,D. and Ventura,M.
  TITLE     Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic
            pathways for host-derived glycan foraging
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (2010) In press
   PUBMED   20974960
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 12340)
  AUTHORS   Ventura,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-NOV-2009) Department of Genetics, Biology of
            Microorganisms, Anthropology and Evolution, University of Parma,
            Italy
COMMENT     Source DNA and bacteria are available from Marco Ventura,
            Laboratory of Probiogenomics, University of Parma.
            marco.ventura@unipr.it.
FEATURES             Location/Qualifiers
     source          1..12340
                     /organism="Bifidobacterium bifidum PRL2010"
                     /mol_type="genomic DNA"
                     /strain="PRL2010"
                     /isolation_source="infant stool sample"
                     /host="Homo sapiens"
                     /db_xref="taxon:702459"
     gene            complement(1..1023)
                     /gene="galE"
                     /locus_tag="BBPR_1050"
     CDS             complement(1..1023)
                     /gene="galE"
                     /locus_tag="BBPR_1050"
                     /EC_number="5.1.3.2"
                     /codon_start=1
                     /transl_table=11
                     /product="GalE UDP-glucose 4-epimerase (Leloir pathway)"
                     /protein_id="ADP36117.1"
                     /translation="MTTILVTGGAGYIGTHTDVELLNKGYDVVCVDNYSNSSPKALDRV
                     EEITGKTVKRYEGDVRDEALMDRIFTENDIDWVIHFASLKSVGESVAKPIEYYDNNLNS
                     TIVLLKAMRAHDVKKVIFSSSATVYGTPKELPLTEESQIGGTTNPYGTTKFFEEQILRD
                     VHVADDSWTVVILRYFNPVGAHESGLIGEDPKGIPANLTPYIAKVALGELKEVQVFGDD
                     YDTPDGTGVRDYIHVVDLAKGHVAVIDKVEGPGVFTYNLGTGHGYSVLEVIKAYEKAAG
                     HAIPFAIKPRRPGDIAACYADSSKAERELGWKAELGIDDMAASSMNWQTKNPSGYRDAE
                     "
     gene            complement(1069..2583)
                     /gene="galT2"
                     /locus_tag="BBPR_1051"
     CDS             complement(1069..2583)
                     /gene="galT2"
                     /locus_tag="BBPR_1051"
                     /EC_number="2.7.7.12"
                     /codon_start=1
                     /transl_table=11
                     /product="GalT2 Galactose-1-phosphate uridylyltransferase
                     (Leloir pathway)"
                     /protein_id="ADP36118.1"
                     /translation="MTTEEKKDDCACGGLDAVYASIDALVDFARKRLELDPRDADWTRN
                     RIFELFSLDSYRPTGATSDDTLPDDLLTRFRAAAVAAGLFDADEGPVYADIVMGMLSGT
                     PSAVQDRFEAVEREHGGMEAMRWFYDYCVANNYVKKGVLDKNPRFDSHGLVITINLAKP
                     EFKNMKKAAAGNSVAGGYPACTICHENEGFAGRNKRTLRTIPATLGDEPWFWQFSPYGY
                     FYQHGICVNDEHTPMHVSRSTFGHLLDFVDRFPGYFLGCNAALPRIGGSVLAHDHYQGG
                     GELLPMHKAAAWATMTLPEYPDATIEILDWPGTAVRVVAKSRDTIIEVCDKIREGWINY
                     SNPELDIICEGEDGKRSAVSPSAIITERGYEMSLIFRNNSVSEELPEGIFHAHPEFWPV
                     KQEPIGLIEAQGLFILPGRLINQLGLIEDALAEGKPLPEEVGEFTLEWDELTATLNGER
                     DRDAIHAAVQDELGSVCERILGNTAVFKHKELTRDFMEGLGFHTQH"
     gene            complement(2583..3671)
                     /gene="nahK"
                     /locus_tag="BBPR_1052"
     CDS             complement(2583..3671)
                     /gene="nahK"
                     /locus_tag="BBPR_1052"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylhexosamine-1-kinase NahK"
                     /protein_id="ADP36119.1"
                     /translation="MTDIDPKLAAIVDQFAIDGDVKGITAYGDGHINVTFLINTDQHRY
                     ILQKMNTDIFPDTVHLMRNIELVTAYLRSKNQETLDIVPTKDGASYIENEEVDGAWRIY
                     KFIEGTISYNLVPNADVFRESGAAFGEFQNFLAGFDASQLTETIAHFHDTPSRFRDFKA
                     ALEADKMGRAETCKPEVDFFLAHEDQYSRIMDGLADGSVPLRVTHNDTKLNNILMDAKT
                     GKARAIIDLDTIMPGSMLFDFGDSIRFGASTALEDEKDLDKVHFSTELFRAYAEGFVGK
                     VRDSITDKEAELLAFAGNMMTMECGMRFLADYLAGDTYFATKYPEHNLVRARTQIKLVQ
                     EMEQKADEIRAIVDDVMERTAR"
     gene            3961..5115
                     /locus_tag="BBPR_1053"
     CDS             3961..5115
                     /locus_tag="BBPR_1053"
                     /EC_number="2.7.1.2"
                     /codon_start=1
                     /transl_table=11
                     /product="Sugar kinase, ROK family"
                     /protein_id="ADP36120.1"
                     /translation="MTSYANTISFPLHTPGRTTKASPADVRRNNRSLVFGLLFPNGQLS
                     RADLGRQTGLSRVAISGVANSMLDEGLICESGFDVNASGKGKRGTLLSIDTSRLHIISV
                     DLSQEHLVQGAVTDLLGTPQQRMEMALGPDNDINADMIVQLVDQLRTDIDADTIIGIGI
                     AATGVVEDGVIRESTVLGWRDLDLRGMLERRFGFPVTISNDVVCSMLAERFFGHGDKSM
                     LFIKIDRGIGAATLIDDVTVIGQNHAGGEIGHISLDPESGVLCPCGKRGCLETMVTSPV
                     IRERIRRASTPEEQLDIIRSCGEQLAAALAMPIGLLDINDICVYGPPDIVNAAFLEATQ
                     RRVDMVSSSKFHKHTSVRRCQVGSDIALRGSAIDVVHHYIENGH"
     gene            complement(5258..6199)
                     /locus_tag="BBPR_1054"
     CDS             complement(5258..6199)
                     /locus_tag="BBPR_1054"
                     /EC_number="2.7.1.2"
                     /codon_start=1
                     /transl_table=11
                     /product="Sugar kinase, ROK family"
                     /protein_id="ADP36121.1"
                     /translation="MTVQDTAQQTPADRFRVGIDIGGTKIEAVLVDPQDNVRNVVRIPA
                     RRGNAQVIDDVVSITHEVAGDLFDQVATVGIGIPGQVNPETGRVDNVVNLDIDTLELGA
                     EAGKRLGIPVHVENDVNAAAVGAARMVGGSHPEGTIVFLNFGTGLAAGIVVDGVVQHGF
                     SGAAGEIGHIPIDPNRFPCPCGQSGCLETVCSGASVGRHWPVEGKPPMPDLIECARRGE
                     PDAQRILVMVTHAIVDAVQIVAQSYDPRMIIFGGGMAKTGQPLIDVTLDELRVRERTCP
                     FLTGLHLGERIKLAQLDQPVGALGAAWAAPEA"
     gene            complement(6428..8683)
                     /gene="lnbP"
                     /locus_tag="BBPR_1055"
     CDS             complement(6428..8683)
                     /gene="lnbP"
                     /locus_tag="BBPR_1055"
                     /codon_start=1
                     /transl_table=11
                     /product="GH112"
                     /protein_id="ADP36122.1"
                     /translation="MTSTGRFTLPSEENFAEKTKELAELWGADAIRNSDGTHLDESVLA
                     LGKKIYSAYFPTRAHNEWITLHMDETPQVYLLTGRVLAEADIVDVPLMDGFFEEQLKPN
                     RDADPHKYWEVVDRTTNEVVDASLWTLDEDTDTVHVSGATPMHEYTVSFLAYIIWDPVE
                     MYNHLTNGWGDKEHEIPFDIYHPATRKFVFDTFEQWLKDNPQVDVVRFTTFFYQFTLLF
                     DQKQREKVVDWFGCACTVSPAALDDFEKEYGYRLRPEDFVDGGAYNSAWRVPRKAQRDW
                     IDFLSGFVRANVKKLADMSHEAGKEAMMFLGDQWIGTEPYKDGFEDLGLDAVVGSIGDG
                     TTTRMIADIPGVKYTEGRFLPYFFPDTFYEGNDPSIEGLDNWRKARRAILRSPISRMGY
                     GGYLSLAAKFPKFVDTVTHIADEFRDIHDRTGGVAAEGELNVAILNSWGKMRSWMAFTV
                     AHALPNKQTYSYYGILESLSGMRVNVRFISFDDVLEHGVADDIDVIVTGGPVDTAFTGG
                     DVWKNPKLTETLRAWVRGGGAFVGVGEPSSLARFQAGRFFQLADVLGVDEERYQTLSVD
                     KYFPTVTPEHFITADVHVDPAAREAWEKAGYRIPLSGCGGGQGIKPLGGIDFGEPVANT
                     FPVNEDVTLLRADGGQVQLAVNEYGKGRGVYISGLPYSAANARLLERALFWASHNEDKY
                     TAYSSTNPECEVAVFPDAGQYCVINNTDRPQSTDVALPDGSVEHFDLDQSAIAWRNL"
     gene            complement(8935..9885)
                     /locus_tag="BBPR_1056"
     CDS             complement(8935..9885)
                     /locus_tag="BBPR_1056"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|D6ZW62|3.A.1.1.48"
                     /protein_id="ADP36123.1"
                     /translation="MSSATAEARANKKRERRLEKQREAAQHDLPRSMRPSPAVKTLTVI
                     VLVLALIYFLFPIYWAIIASTKTPSQMTSGNGLWFSVSLDQIPNAVATNYSKLLGWTRG
                     NFWRWVLNSLIYSGVSALIGTIVSVMAGYATAKFNFRGKNVAIGIIMACMLMPAALLTI
                     PQYSIFHALKLTNTMASIIIPCCVSPFGFFLGRTYAQSSVPDELLEAARIDGASEARIF
                     FTIVLRLLAPAMVTIFLFLFVATWNNFLLPLMMVSSDALKPVTLGLYGMVSLATFTDRG
                     ALMMGALLGVLPVIVIFLGLQRYWQSGLAAGAVKG"
     gene            complement(9885..10856)
                     /locus_tag="BBPR_1057"
     CDS             complement(9885..10856)
                     /locus_tag="BBPR_1057"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|D6ZW63|3.A.1.1.48"
                     /protein_id="ADP36124.1"
                     /translation="MTASITQAKGAAPKRAAAKPKRSKAFKRENRTGWAFMAPFAILFA
                     FVFLLPIIWAVYSSFFRQVSQGGGLYGGGELVNEFVGFQNFQYVITSGKFWTGVGHVLL
                     YTVIQVPIMIIAALALAMVIDSFVVKHVTGFRLGYFLPYAIPGVVASIIWVYLYNGQIS
                     PIVKGLESIGIHVDFFANNVVLGSMANITTWTFTGYNMLIFLAALQAIPHDLYEAARID
                     GANGFQVAMKIKLPNVRGAALLAMLLSIVGTIQLFNEPQIMSTADPGISKAYTPMMMAM
                     NTSQGTLTPSGDGPASAIAIVMALIAGLLAVVYTLAERKVNE"
     gene            complement(11033..12340)
                     /locus_tag="BBPR_1058"
     CDS             complement(11033..12340)
                     /locus_tag="BBPR_1058"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|D6ZW64|3.A.1.1.48"
                     /protein_id="ADP36125.1"
                     /translation="MVAKKRLLAGLASLTVMGIALAGCGPSTNNGSNTPKDEKVTITYM
                     HRLPDKEGMTLVNDIVAKWNKDNPNIQVKATKFDGAAQDMIKKLATDVKAGAAPDLAQV
                     GYAELPEVFNQGLLQDVTEEAAKYKDHFAEGPFSMMQIGGKAYGLPQDTGPLTYFYNAK
                     EFEKLGITVPKTADELIATAKKTAAQGKYIMTFQPDEGMMTMSGTSGASGEWYKTEGNA
                     WKVDTQTAGSKAVAKVYQQLLDDKSALTNPRWDPSFDASINKGQLIGTVAAAWEAPLFI
                     SSAGGTGKGEWKVAQLPDWFGNGTKTGSDGGSGVAVLKGSKHPAEAMKFLDWFNTQVPD
                     LVSQGLVVAATTEAAKTPAAWSEFFSNQDIMAEFKKANDNMASFSYIPGFSAVGSAMNE
                     TAAKAATGDAKVSDIFDTAQTTSVEALKNAKLPVKE"
ORIGIN
        1 tcactcggcg tcgcggtaac cgctcgggtt cttggtctgc caattcatcg acgacgcagc
       61 catgtcgtcg atgccgagct cggccttcca gccgagttca cgctcggcct tggaggagtc
      121 ggcgtagcag gcggcgatgt cgccggggcg acgcggcttg atcgcgaacg gaatcgcgtg
      181 gccggcagcc ttctcgtacg ccttgatgac ctcaagtacc gagtatccgt gaccggtacc
      241 caggttgtag gtgaacacgc cggggccctc gaccttgtcg atgacggcga cgtggccctt
      301 ggccagatcg acaacgtgga tgtagtcgcg cacgccggtt ccgtcgggcg tgtcatagtc
      361 gtcaccgaac acctgaacct ccttgagctc gccgagtgca accttggcga tgtagggggt
      421 caggtttgcc ggaatgccct tcggatcctc gccgatcagg ccggactcgt gggcgccgac
      481 cgggttgaag tagcgcagga tgacgacggt ccaggagtcg tcggcaacgt gcacgtcgcg
      541 caggatctgc tcctcgaaga acttggtcgt gccgtacggg ttcgtggtgc cgccgatctg
      601 gctctcctca gtcagcggca gctccttggg cgtgccatag acggtggcgg acgacgagaa
      661 gatgaccttc ttgacgtcgt gggcgcgcat ggccttgagc agcacgatgg tgctgttgag
      721 gttgttgtcg tagtattcga tcggcttggc gaccgactcg ccgacggact tgagcgaggc
      781 gaaatgaatc acccagtcga tgtcgttctc ggtgaagatg cggtccatca gcgcctcatc
      841 gcggacatcg ccctcgtagc gcttgacggt cttgccggtg atctcctcga cgcgatcgag
      901 cgccttgggc gacgagttgc tgtagttgtc cacgcagaca acgtcgtacc ccttgttcag
      961 cagctcgaca tcggtgtgcg taccgatgta gcccgcgccg cccgttacca gaatggtagt
     1021 catgtgttcc tccttgaaaa acagctgtgg atgactccaa cagtcattct aatgctgagt
     1081 atggaatccg aggccttcca tgaagtcccg ggtgagttcc ttgtgcttga acacggccgt
     1141 gttgcccagg atgcgctcgc atacgctgcc gagttcgtcc tgcaccgcgg cgtggatggc
     1201 gtcgcggtcg cgctcgccgt tcagtgtcgc ggtgagttcg tcccattcga gcgtgaactc
     1261 gccgacctct tccggcagcg gcttgccctc ggcgagggcg tcctcgatca ggccaagctg
     1321 gttgatgaga cggccgggca ggatgaacag cccctgcgcc tcgatcaggc cgatgggctc
     1381 ctgcttgacc ggccagaact cgggatgcgc atggaagatg ccttccggca gttcctcgct
     1441 gaccgagttg ttgcggaaga tcaggctcat ttcgtagccg cgctcggtga tgatcgcgct
     1501 gggcgacacc gcggagcgct tgccgtcctc gccttcgcag atgatgtcca gctcggggtt
     1561 ggagtagttg atccagcctt cgcggatctt gtcgcacacc tcgatgatcg tgtcgcgcga
     1621 tttggcgacc acgcgcacgg cggtgccggg ccagtcgagg atctcgatgg tcgcgtccgg
     1681 gtattccggc agcgtcatcg tcgcccaggc ggccgccttg tgcatcggca gcagttcgcc
     1741 gccgccctgg taatggtcgt gggcgagcac ggagccgccg atgcgcggca gcgcggcgtt
     1801 gcacccgagg aagtatccgg ggaaccggtc gacgaagtca agcaggtgcc cgaacgtgga
     1861 gcggctcacg tgcatgggcg tgtgctcgtc gttcacgcag atgccgtgct ggtagaagta
     1921 cccgtacggg gagaactgcc agaaccacgg ttcgtcgccg agcgtggcgg ggatggtgcg
     1981 cagcgtgcgc ttgttgcgcc ccgcgaagcc ctcgttctca tggcagatcg tgcatgcggg
     2041 gtatccgccg gccaccgagt tgcccgcggc ggccttcttc atgttcttga attcgggctt
     2101 ggcgaggttg atggtgatga ccaggccgtg ggagtcgaag cgcgggttct tgtcgagcac
     2161 gcccttcttg acatagttgt tggcgacgca gtagtcgtag aaccagcgca tggcctccat
     2221 gccgccatgt tcgcgttcca ctgcctcgaa ccggtcctgc acggcggacg gcgtgccgga
     2281 gagcatgccc atcacgatgt ccgcgtacac gggtccttcg tcggcgtcga acagccccgc
     2341 cgcgacggcc gcggcgcgga accgcgtcag caggtcgtct ggcagcgtgt cgtcgctggt
     2401 cgcgccggtg ggacggtacg agtcgagcga gaacagctcg aagatgcggt tgcgcgtcca
     2461 gtcggcatcg cgcgggtcga gttcaagccg cttgcgcgcg aagtcgacga gcgcgtcgat
     2521 gctcgcgtag acggcgtcga gtccgccgca ggcgcagtcg tccttcttct cttccgtggt
     2581 catcagcggg cggtcctttc catgacgtcg tcgacgatgg cgcgaatctc gtcggccttc
     2641 tgctccatct cctgcacgag cttgatctgg gtgcgagcgc gcacgaggtt gtgctcgggg
     2701 tacttggtgg cgaagtacgt gtcaccggcg aggtagtcgg cgaggaagcg catgccgcat
     2761 tccatcgtca tcatgttgcc ggcgaatgcg agcagctcgg cctccttgtc ggtgatgctg
     2821 tcgcgcacct tgccgacgaa gccctccgcg taggcgcgga acagttcggt gctgaagtgg
     2881 accttgtcga gatccttctc gtcttcaagc gcggtggacg cgccgaagcg gatggaatcg
     2941 ccgaagtcga acagcatgga acccggcatg atggtgtcga ggtcgatgat ggcacgggcc
     3001 ttgccggtct tcgcgtccat caggatgttg ttgagcttgg tgtcgttgtg ggtgacgcgc
     3061 agcggaacgg agccgtcggc cagcccgtcc atgatgcggg agtactggtc ttcgtgggcg
     3121 aggaagaagt cgacctccgg cttgcaggtt tcggcgcggc ccatcttgtc ggcttccagc
     3181 gcagccttga agtcgcggaa gcggctcggc gtgtcgtgga agtgggcgat ggtctcggtc
     3241 agctgggagg cgtcgaagcc ggccagaaag ttctggaact cgccgaacgc ggcgccggac
     3301 tcgcggaaca cgtcggcgtt ggggacgagg ttgtaggaga tggtgccttc gatgaacttg
     3361 tatatcctcc aggcgccgtc cacctcctcg ttttcgatgt agctcgcgcc gtccttggtg
     3421 gggacgatgt cgagcgtctc ctggttcttg gagcgcaggt aggcggtgac gagttcgatg
     3481 ttgcgcatca ggtgcacggt gtccgggaag atgtccgtgt tcatcttctg caggatgtac
     3541 cggtgctgat ccgtgttgat caggaaggtg acgttgatgt ggccgtcacc gtatgcggtg
     3601 atgcccttga cgtcgccgtc gatggcgaac tgatcgacga tggccgccag tttcggatca
     3661 atgtcagtca tgtggaaccc tcttttcctt gttgtgccgc aggttgccgc cggtcttcac
     3721 cgccacaacg accccctatc tgaagctgct gtgccactgc gacgcagcag ctgttggcgc
     3781 atacgcaccg ttatttgtta attatagtta cataaatgac aaaccgccat tcttcggcgt
     3841 ttatagttcc tgaatcccct tttctattgc tataatataa agactgtgga tttgaacatg
     3901 accacaccgc agctcgcatg atccgaatca tgggcgctct gacaagaaac gactgaacca
     3961 atgacctcgt acgccaacac catctcgttc cccctgcaca cgcccggcag gacgacgaag
     4021 gcaagtcccg ccgacgtgcg ccgcaacaac cgttccctgg tgttcgggct gctgttcccg
     4081 aacgggcagc tatcccgcgc cgacctcggg cggcagaccg gactctcgcg cgtggcgata
     4141 tcgggagtcg ccaacagcat gctcgacgaa gggctgatct gcgagagcgg tttcgacgtc
     4201 aacgcctccg gcaagggcaa gcgcggcacg ctgctgagca tcgacacgtc gcgtctgcac
     4261 atcatcagcg tcgacctgtc ccaggagcat ctggtgcagg gagccgtgac cgacctgctg
     4321 ggcacgccac agcagcgcat ggaaatggcg ctcggaccgg ataacgacat caacgcggac
     4381 atgatcgtgc agctggtcga ccagctgcgc accgacatcg acgccgacac gatcatcggc
     4441 atcggcatag cggcgactgg tgtcgtcgag gacggtgtca ttcgcgaatc gacggtgttg
     4501 ggatggcggg accttgatct gagaggcatg ctggaacgtc gtttcggatt ccccgtcacc
     4561 atcagcaacg acgtcgtctg ctccatgctc gcggagcgat tcttcgggca tggcgacaag
     4621 agcatgctgt tcatcaagat cgaccgtggc atcggtgccg cgacgctgat cgacgatgtg
     4681 actgtgatcg ggcagaacca tgccggaggc gagatcgggc atatctccct cgacccggag
     4741 tcgggggtgt tgtgtccgtg cggcaagcgc gggtgcctgg agacgatggt cacatcgccg
     4801 gtaattcgcg agcggattcg ccgcgcgtcg acgcccgagg agcagctgga catcatccga
     4861 tcctgcggcg agcagctcgc cgcggcgctc gccatgccaa tcggcctgct cgacatcaac
     4921 gacatatgcg tgtacggccc gccggacatc gtgaacgcgg cgttcctgga ggcgacgcag
     4981 cgccgtgtgg acatggtgtc gtcgtcgaag ttccacaagc atacctccgt gcgacggtgc
     5041 caggtgggtt cggatatcgc gctgcgcgga tccgccatcg acgtggttca tcattacatc
     5101 gagaacggtc actgagagaa ccaccgaaag gtccttgcga tatgaatcga gggccgctcc
     5161 cccgttcagg gagcggccct cgattcatgt tctgctcaca tccggccgtg cggcccgggt
     5221 ggttttggaa actccgtcgc cggtaccggt gtgcctatca ggcctccggc gcggcccacg
     5281 cggcgcccag cgctccgacc ggctggtcga gttgcgcaag cttgatgcgt tcgccgagat
     5341 gcaggcccgt caggaacggg caggtgcgct cgcgcacgcg caattcgtcc agggtgacgt
     5401 cgatgagcgg ctggccggtc ttcgccatgc caccgccgaa gataatcatg cgcgggtcat
     5461 aggattgtgc gacgatctgc acggcgtcga cgatggcatg ggtgaccatg acgagtatgc
     5521 gctgggcgtc aggctcgccg cgacgggcgc actcgatgag atccggcatc ggaggcttgc
     5581 cttcgaccgg ccagtgacgg ccgaccgacg ctccggagca cacggtctca agacagccgc
     5641 tctgcccgca ggggcacggg aagcggttcg ggtcgatcgg gatatggccg atctcgccgg
     5701 cggcgccgct gaaaccgtgc tggacgacgc cgtcgacgac gatgcccgcg gcgagtccgg
     5761 tgccgaagtt gaggaacacg atggttcctt cggggtggga tccgccgacc atacgcgcgg
     5821 cgccgaccgc ggccgcattg acgtcgttct cgacgtgcac gggaataccg aggcgcttgc
     5881 ccgcttcggc accaagctcc agcgtatcga tgtcgaggtt gacgacgttg tcgacacgac
     5941 cggtttctgg attgacctgt ccggggatgc cgatgccgac cgtggcgacc tgatcgaaca
     6001 gatcgccggc cacctcatgg gtgatcgata cgacgtcgtc gatgacctgc gcgttgccgc
     6061 gtcgtgcggg aatgcgcacg acgttgcgaa cattatcctg cggatcgacg agaacggcct
     6121 cgatcttggt gccgccgatg tcgatgccga cgcggaagcg gtcggcaggt gtctgctgtg
     6181 ctgtatcctg cactgtcatg tgttgtgtcc ttacgtaaca gcggatatgc gcggttcgca
     6241 catccttgac gaatatgtgg ggcaaggcat atcgtcatgc cttgccccac cgatgggtct
     6301 gagtgtcagg gcctccggag gaaggagaag gaaagcacgg aagccctgat cctcaagtct
     6361 tgctgtccga tccatctgtc cccgtccgtc ccgcatcatg ccgcgggacg gacggggact
     6421 gcacagatca gaggttgcgc caagcgatgg cgctctggtc gaggtcgaaa tgctcgaccg
     6481 aaccgtcagg cagagccaca tccgtggact gcggacggtc ggtgttgttg atcacgcagt
     6541 actggccggc atcggggaac accgcgacct cgcactcggg gttggtggag ctgtatgccg
     6601 tgtacttgtc ctcgttgtgg gaggcccaga acagggcacg ctccagcaga cgggcgttcg
     6661 cggccgagta gggcagaccg gagatgtata cgccgcggcc cttgccgtac tcgttgaccg
     6721 cgagctgcac ctgaccaccg tcggcgcgca gcagcgtcac gtcctcgttg accgggaacg
     6781 tgttcgcgac cggctcgccg aagtcgatgc cgccaagcgg cttgatgccc tggccaccgc
     6841 cgcagcccga cagcgggatg cggtatccgg ccttctccca cgcttcgcgg gcggcgggat
     6901 cgacatgcac gtcggcggtg atgaagtgct ccggcgtgac ggttgggaag tacttgtcca
     6961 ccgacagcgt ctggtagcgt tcctcgtcca cgcccagcac gtcggccagc tggaagaaac
     7021 gaccagcctg gaaacgggcc agcgaactgg gctctccgac gccgacgaat gctccgccgc
     7081 cgcgcaccca ggcgcgcagg gtctcggtca gcttcgggtt cttccacacg tctccaccgg
     7141 tgaacgcggt gtcgaccggg ccaccggtca cgatcacgtc gatgtcgtcg gcgacgccat
     7201 gctccagcac gtcatcgaag ctgatgaacc gcacgttcac gcgcatgccc gacagcgact
     7261 ccagaatgcc gtaatacgaa tacgtctgct tgttcggcag cgcgtgggcg accgtgaacg
     7321 ccatccacga acgcatcttg ccccacgagt tcagaatcgc cacgttgagc tcgccttcgg
     7381 cggcgactcc accggtacgg tcatggatgt cgcggaactc gtcggcgatg tgggtgacgg
     7441 tatcgacgaa cttcgggaac ttcgcggcca gcgacaggta tccgccgtag cccatacgcg
     7501 aaatcgggga acgcaggatg gcacgacgcg ctttacgcca gttgtcgaga ccttcgatgc
     7561 tcggatcgtt gccctcgtag aacgtgtcgg ggaagaagta cggcaggaaa cgaccctccg
     7621 tgtacttcac gcccgggatg tccgcgatca tgcgggtcgt ggtgccgtca ccgatcgaac
     7681 cgacgacagc atccaggccc agatcctcga aaccatcctt gtacggctcg gtaccgatcc
     7741 actggtcacc caggaacatc atcgcttcct tgccggcctc gtgcgacatg tcggcgagct
     7801 tcttgacatt ggcgcgaacg aaaccggaga ggaagtcgat ccagtcgcgt tgggccttgc
     7861 gcggcacgcg ccacgcggag ttataggcgc cgccatctac gaagtcttcg gggcgtaggc
     7921 ggtagccgta ctccttctcg aagtcgtcga gcgcggccgg gctcacggtg caggcgcatc
     7981 cgaaccaatc cacgaccttc tcgcgctgct tctggtcgaa cagcagcgtg aactggtaga
     8041 agaacgtcgt gaaacgcacg acatccacct gcgggttgtc cttgagccac tgctcgaacg
     8101 tgtcgaacac gaacttgcgc gtcgccgggt ggtagatatc gaacggaatc tcgtgctcct
     8161 tgtcgcccca cccgttcgtc aggtggttgt acatctcgac cggatcccag atgatgtacg
     8221 cgaggaacga gaccgtgtac tcgtgcatcg gcgtcgcgcc ggagacatgc acggtatcgg
     8281 tgtcctcatc aagcgtccac agggaggcat ccacgacctc attggtggtg cggtccacga
     8341 cttcccagta cttgtgcggg tcggcgtcac ggttcggctt gagctgctcc tcgaagaagc
     8401 cgtccatcag gggaacatcc acgatgtccg cttccgccag gacgcgcccg gtgagcaggt
     8461 acacctgcgg ggtctcgtcc atgtgcagcg tgatccactc gttgtgtgca cgggtcggga
     8521 agtaggcgct gtagatcttc ttgccgagtg cgagcacgga ctcgtcaagg tgtgtgccat
     8581 cggaattacg gatggcatca gcgccccaca attcggcaag ttccttggtt ttttcagcga
     8641 agttctcttc actgggcaat gtgaagcggc cagtgctggt catgggttct ccttcttggg
     8701 aacagtcatc ggggaaagat atatgggtga tgaaatcacg aaggccgatg aaatggccgg
     8761 catcatcgca ggcccgctgg atcctgactg cgcaaatcct tgacgcctac gatgacgctg
     8821 gacgatggta atcgtgtcac tgatcgaggt gatggccgta ccgcccggca ctcagtgaca
     8881 catcatgccg ggcggcggtt cgtggttttc tcccgcacat ggcgggagaa aacatcagcc
     8941 cttgacggcg ccggcggcca ggccggactg ccagtagcgc tggagaccga ggaagatcac
     9001 gatcaccggc agcacgccga gcagtgcgcc catcatcagg gcgccgcgat cggtgaatgt
     9061 ggccaacgac accatgccgt acagacccag ggtcaccggc ttgagggcgt cggaggacac
     9121 catcatcaac ggcagcagga agttgttcca cgtggcgacg aacaggaaca ggaagatcgt
     9181 caccattgcc ggggcgagaa gtcgcagcac gatggtgaag aaaatcctgg cttcgctcgc
     9241 gccgtcgatg cgggcggctt caagcagttc atcaggcaca gagctctggg cgtacgtacg
     9301 gcccaggaag aagccgaacg gcgagacaca gcacgggatg atgatggacg ccatcgtgtt
     9361 ggtcagcttc agagcgtgga agatcgagta ctgggggatg gtgagcaggg cggcaggcat
     9421 cagcatgcag gccatgatga tgccgatggc gacgttcttg ccgcggaagt tgaacttcgc
     9481 ggtggcgtag ccggccatga cggacacgat ggtgccgatg agtgcggaga cgcccgagta
     9541 gatcagcgag ttcagcaccc agcgccagaa gttgccacgg gtccagccga gcagcttgga
     9601 gtagttggtg gccacggcgt tggggatctg gtcgagcgac acggagaacc acaggccatt
     9661 gccgctggtc atctgggagg gcgtcttggt ggacgcaatg atggcccagt aaatcgggaa
     9721 caggaagtag atcagcgcca acaccagtac gatgaccgta agtgtcttga ctgcaggcga
     9781 cggcctcatg gaacggggca gatcgtgctg tgcagcctcg cgctgcttct ccaaacgacg
     9841 ttcgcgcttc ttgttcgcgc gcgcttcagc ggttgcagag ctcattactc gttcaccttc
     9901 ctttcagcaa gggtgtacac gacggcaagc agacctgcga tcagtgccat gacgatggcg
     9961 atggctgatg cggggccgtc acctgacggg gtaagcgttc cctgcgaagt attcatggcc
    10021 atcatcatcg gcgtgtacgc cttggagatg cccggatccg cggtggacat gatctgcggc
    10081 tcgttgaaca gctggatggt gccgacgatg gacagcagca tggcgagcag cgccgcgcca
    10141 cgcacgttcg gcagcttgat cttcatggcg acctggaagc cgttggcacc atcgatgcgg
    10201 gcggcctcat acaggtcgtg cgggatggcc tgcagcgcgg cgaggaagat cagcatgttg
    10261 taaccggtga acgtccaggt cgtgatgttg gccatggaac cgaggacaac gttgttggca
    10321 aagaagtcga catggatgcc gatggactcc agacccttga cgattgggga aatctgaccg
    10381 ttgtacaggt agacccagat gatggaggcg acgacgccgg ggatggcgta gggcaggaag
    10441 tagcccagac ggaaaccggt aacgtgcttg acgacaaacg aatcgatgac catagccagc
    10501 gcaagggcgg cgatgatcat gatcggcacc tggatgacgg tgtagagcag cacatggccg
    10561 acaccagtcc agaatttgcc ggaagtgatg acgtattgga agttctggaa tccgacgaac
    10621 tcgttgacca gttcgccgcc gccatagagg ccgccgcctt ggctgacctg acggaagaag
    10681 ctggaataga cggcccagat gatgggcagg aggaacacga aggcgaacaa gattgcgaac
    10741 ggcgccatga acgcccagcc ggttcggttc tcgcgcttga atgccttcga gcgctttggc
    10801 tttgcggcgg cgcgtttcgg cgcggcaccc ttggcctgag taatggatgc agtcataata
    10861 caaacctgtc ttttcgaaaa acagaaaaac gattccacga gcatgtactc ttggacatat
    10921 gaaaggccgg agtccgaatc cccggccttt cattttatga tgcctgaggc atcggtggtc
    10981 ttgggtgatg gacggaactt ttcagcttat ccatcaccgg accgggttat gttcactcct
    11041 tgacagggag cttggcgttc ttcagcgctt cgacggaagt cgtctgagcg gtgtcgaaga
    11101 tgtcggagac cttggcgtca ccagtggcgg ccttggcagc agtctcgttc atcgctgaac
    11161 ccacggcgga gaagcccggg atgtagctga acgaagccat gttgtcgttc gctttcttga
    11221 actcagccat gatgtcctgg ttgctgaaga actcggacca cgcagccgga gtcttggcag
    11281 cctcagtggt ggcggccacg accagaccct gggagaccag atccggaacc tgggtgttga
    11341 accagtcgag gaacttcatg gcctcggccg ggtgcttcga gcccttgagc acagccacgc
    11401 cggaaccacc gtcggagccg gtcttggtgc cgttgccgaa ccaatcgggc agctgggcga
    11461 ccttccactc ccccttgccg gtgccaccgg cggagctgat gaacagcggg gcttcccaag
    11521 cggcagccac agtgccgatc agctgaccct tgttaatgga ggcgtcgaag gacggatccc
    11581 aacgcgggtt ggtgagcgcg gacttgtcgt cgagcagctg ctggtacacc ttggccacgg
    11641 ccttggagcc tgcagtctgg gtgtcgacct tccaggcatt accctcagtc ttgtaccact
    11701 cgccggaagc gccggaagtg ccggacatcg tcatcatgcc ctcatcgggc tggaacgtca
    11761 tgatgtactt accctgggcg gcggtcttct tggcggtcgc gataagctcg tcagcggtct
    11821 tcggcacggt gatgccgagc ttctcgaact ccttggcgtt gtagaagtac gtcagggggc
    11881 cggtgtcctg cggcagaccg taggccttgc caccgatctg catcatggag aacggaccct
    11941 cagcgaagtg gtccttgtac ttcgcggcct cttcggtgac gtcctgcaac aggccctgat
    12001 tgaagacctc aggcaactcg gcgtatccga cctgagccag atcaggagcg gcgccggcct
    12061 tgacgtcggt cgccagcttc ttgatcatgt cctgagccgc accatcgaac ttggtggcct
    12121 tgacctggat gttcgggttg tccttgttcc acttggccac gatgtcattg accagcgtca
    12181 tgccctcttt atccggcagg cgatgcatgt aggtgatcgt caccttttcg tctttggggg
    12241 tattgctgcc gttgttcgtg gatggaccgc aaccggcaag ggcgatgccc atgacagtca
    12301 gcgacgccag accagcaagc agtcgtttct tagctaccat
//
