LOCUS       NC_002737              11962 bp    DNA     linear   CON 10-MAR-2020
DEFINITION  Streptococcus pyogenes M1 GAS, complete sequence.
ACCESSION   NC_002737
VERSION     NC_002737.2
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604089
            Assembly: GCF_000006785.2
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes M1 GAS
  ORGANISM  Streptococcus pyogenes M1 GAS
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11962)
  AUTHORS   Nasser,W., Beres,S.B., Olsen,R.J., Dean,M.A., Rice,K.A., Long,S.W.,
            Kristinsson,K.G., Gottfredsson,M., Vuopio,J., Raisanen,K.,
            Caugant,D.A., Steinbakk,M., Low,D.E., McGeer,A., Darenberg,J.,
            Henriques-Normark,B., Van Beneden,C.A., Hoffmann,S. and Musser,J.M.
  TITLE     Evolutionary pathway to increased virulence and epidemic group A
            Streptococcus disease derived from 3,615 genome sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 111 (17), E1768-E1776 (2014)
   PUBMED   24733896
REFERENCE   2  (bases 1 to 11962)
  AUTHORS   Ferretti,J.J., McShan,W.M., Ajdic,D., Savic,D.J., Savic,G., Lyon,K.,
            Primeaux,C., Sezate,S., Suvorov,A.N., Kenton,S., Lai,H.S., Lin,S.P.,
            Qian,Y., Jia,H.G., Najar,F.Z., Ren,Q., Zhu,H., Song,L., White,J.,
            Yuan,X., Clifton,S.W., Roe,B.A. and McLaughlin,R.
  TITLE     Complete genome sequence of an M1 strain of Streptococcus pyogenes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (8), 4658-4663 (2001)
   PUBMED   11296296
REFERENCE   3  (bases 1 to 11962)
  AUTHORS   Beres,S.B. and Musser,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-APR-2014) Center for Molecular and Translational Human
            Infectious Diseases Research, Department of Pathology and Genomic
            Medicine, Houston Methodist Research Institute, Houston, TX 77030,
            USA
  REMARK    Sequence update by submitter
REFERENCE   4  (bases 1 to 11962)
  AUTHORS   Ferretti,J.J., McShan,W.M., Adjic,D., Savic,D., Savic,G., Lyon,K.,
            Primeaux,C., Sezate,S.S., Surorov,A.N., Kenton,S., Lai,H., Lin,S.,
            Qian,Y., Jia,H.G., Najar,F.Z., Ren,Q., Zhu,H., Song,L., White,J.,
            Yuan,X., Clifton,S.W., Roe,B.A. and McLaughlin,R.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-APR-2001) Department of Microbiology and Immunology,
            University of Oklahoma Health Sciences Center, 940 SL Young Blvd,
            Oklahoma City, OK 73104, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/10/2020 06:09:16
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 1,857
            CDSs (total)                      :: 1,775
            Genes (coding)                    :: 1,720
            CDSs (with protein)               :: 1,720
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 37 of 55
            Pseudo Genes (incomplete)         :: 14 of 55
            Pseudo Genes (internal stop)      :: 18 of 55
            Pseudo Genes (multiple problems)  :: 13 of 55
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AE004092.
            On Jun 15, 2015 this sequence version replaced NC_002737.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..11962
                     /organism="Streptococcus pyogenes M1 GAS"
                     /mol_type="genomic DNA"
                     /strain="SF370"
                     /serotype="M1"
                     /db_xref="taxon:160490"
                     /focus=""
     gene            complement(1..927)
                     /locus_tag="SPY_RS06615"
                     /old_locus_tag="SPy1593"
                     /old_locus_tag="SPy_1593"
                     /db_xref="GeneID:901842"
     CDS             complement(1..927)
                     /locus_tag="SPY_RS06615"
                     /old_locus_tag="SPy1593"
                     /old_locus_tag="SPy_1593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044580.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A9QDR8|3.A.1.1.29"
                     /protein_id="WP_002988998.1"
                     /db_xref="GeneID:901842"
                     /translation="MEKKKKVEKVNVRTFDRKTNAIFNILIGLFAISCIIPFIFVIIIS
                     FTDESYLINHGYSFFPDVWSTKAYQYIFQGAMSHRIMRSFGISVFITVVGTFINTTMTS
                     TYAYAISRPYFPYRRFFTVYALITMLFAPGMVANYLVVSNLLHLKDTVWALILPMALGP
                     FGILVMRTFFKKTVPDSIIESARMDGASEWMIFMKIVLPLAVPGIATISLFSALTYWND
                     WFNALLYVQSENLYPMQYLLMKIQSNLQALAQNAGMSAQMADSLASLPKESVRMAIVVI
                     ATLPIALTYPFFQKYFVGGLTIGGVKE"
     gene            complement(937..1887)
                     /locus_tag="SPY_RS06620"
                     /old_locus_tag="SPy1595"
                     /old_locus_tag="SPy_1595"
                     /db_xref="GeneID:901843"
     CDS             complement(937..1887)
                     /locus_tag="SPY_RS06620"
                     /old_locus_tag="SPy1595"
                     /old_locus_tag="SPy_1595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004219264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q09LY7|3.A.1.1.9"
                     /protein_id="WP_011285651.1"
                     /db_xref="GeneID:901843"
                     /translation="MIRQTNKKTSFWKNVIKYRALLLMVLPGFIWFIFFFYIPVLANVV
                     AFKDFHYSAGGFMESLKESPWVGLANFKYLFASKDAWLITRNTIAYNVIFLLFNVFFAI
                     AFAIIMSELRNKRTVKVYHTMSLLPYFLSWVVIEYFVSAFLNTDKGFINQLLTGSGADP
                     IKWYSNPTWWPLILLFMSVWKGLGYNSIIYYASVKGISDTYYEAAMVDGASKWQQIRNI
                     TIPQLLPMMSILLIINIGNIFKSDFGLFYVIPKNSGPLYDVTSVLDTYVYNALTATGDI
                     GMASAASLYQSVVGTSILLVTNAIVRRMDPDAALF"
     gene            2083..2961
                     /locus_tag="SPY_RS06625"
                     /old_locus_tag="SPy1596"
                     /old_locus_tag="SPy_1596"
                     /db_xref="GeneID:901844"
     CDS             2083..2961
                     /locus_tag="SPY_RS06625"
                     /old_locus_tag="SPy1596"
                     /old_locus_tag="SPy_1596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="WP_011285652.1"
                     /db_xref="GeneID:901844"
                     /translation="MSLLCIDIGGTSLKFALCHNGQLSQQSSFPTPSSLEKFYQLLDQE
                     VARYSAYHFSGIAISSPGAVNKEKGVIEGASAIPYIHHFKIQEALEERLHYPISIENDA
                     NCAALAEATLGAGKGASSLAMLVLGTGVGGSLVIDGKIYHGAHLFGGEFGFMIMNDRYQ
                     TFSQLGTVVNMAKRYSAIVNNGKDYTGKAVLALAEQGDPLALKERQVFLQSLAIGIFNI
                     QHAFDPQLILIGGGVSQADFLLSAIEAELDKLYQAVEISDLRPQLAICHFKNEANLLGA
                     AIDFYQEHKEA"
     gene            complement(3572..5014)
                     /locus_tag="SPY_RS06630"
                     /old_locus_tag="SPy1599"
                     /old_locus_tag="SPy_1599"
                     /db_xref="GeneID:901846"
     CDS             complement(3572..5014)
                     /locus_tag="SPY_RS06630"
                     /old_locus_tag="SPy1599"
                     /old_locus_tag="SPy_1599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH1"
                     /protein_id="WP_010922527.1"
                     /db_xref="GeneID:901846"
                     /translation="MLAFPKEFWWGGATSGPQSEGRFAKQHRNLFDYWYEEEPDLFYDY
                     VGPDTASDAYHQIESDLTLLASLGHNSYRTSIQWTRLIDDFEQATINPDGLAYYNRVID
                     ACLANGIRPVINLHHFDLPIALYQAYGGWESKHVVDLFVAFSKVCFEQFGDRVKDWFVH
                     NEPMVVVEGSYLMQFHYPAIVDGKKAVQVAYNLALATAKVIQAYRRGPAELSDGRIGTI
                     LNLTPAYPASQSEADMAAAHFAELWNNDLFMEAAVHGKFPEELVAVLKKDGVLWQSTPE
                     ELALIAENRVDYLGLNFYHPKRVKAPDAIPVISPSWSPEWYYDPYLMPGRRMNVDKGWE
                     IYPEAVYDIAIKMRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTY
                     LHKGIEAGSNCFGYHVWTPIDGWSWLNAYKNRYGLVENNIHTQVRRPKASAYWFKKVAT
                     HNRLISLEVMEEFGGSASHLSD"
     gene            complement(5038..6732)
                     /locus_tag="SPY_RS06635"
                     /old_locus_tag="SPy1600"
                     /old_locus_tag="SPy_1600"
                     /db_xref="GeneID:901847"
     CDS             complement(5038..6732)
                     /locus_tag="SPY_RS06635"
                     /old_locus_tag="SPy1600"
                     /old_locus_tag="SPy_1600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH84"
                     /protein_id="WP_010922528.1"
                     /db_xref="GeneID:901847"
                     /translation="MTIYHALKDYQEVMTRGDYLVFDTPLTCRFIGRFFRFENQKALLA
                     ELATSKYFQWIEEGQAEVTMKHFFNRQLAKDAFTLKISEDKEIIIESQNLRGFRYAQEA
                     LLKVMTFKGDKLYLPIVSVKHSPSFAMRGIIEGFYGTPWTREERLDCLRFIGNKRMNTY
                     MYAPKDDDYQRKLWRDLYPEDWVTYFKELLAVAKEEGLDFWYMISPGLDFDYTKEADYQ
                     LLYQKLQQLLALGVCHFGLLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHA
                     APELVICPTEYDNHHDSIYLQELSERIPKEVAFFWTGPSTLASQISQADIETMAAVYQR
                     PIIIWDNIPVNDYQKDPERLFLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTD
                     MSHYLWDANRYQPSHSWLETLTDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALL
                     AKDVSTLSAWVAELVERVNTLRKLDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLET
                     LYADLQEDKHRIGSDIPSRYYRIYYQQQDKLTANQGQVTQARPEDYA"
     gene            complement(6783..7823)
                     /locus_tag="SPY_RS06640"
                     /old_locus_tag="SPy1602"
                     /old_locus_tag="SPy_1602"
                     /db_xref="GeneID:901849"
     CDS             complement(6783..7823)
                     /locus_tag="SPY_RS06640"
                     /old_locus_tag="SPy1602"
                     /old_locus_tag="SPy_1602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011054789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|GntR,DBD-SUPERFAMILY|0037767"
                     /protein_id="WP_002983707.1"
                     /db_xref="GeneID:901849"
                     /translation="MTKLLYKKIYHFIKEQIASGRLQIGDRLPTEKELSEQFSVSRITS
                     KRALVELEQEGLITRSRGKGSFVAKKQVTSPEANKDLLLILPFASDYELGDYAKGIMTS
                     IAETGYRLMVQLASTVRLDTLSDYAGIIYYPEDVNHSIDFLFYCDHHHIPLVLLDKSLD
                     LFQFPSVVADNKGGACQLTQHLIEQGCDQISFVATGSFGEVSSVRDRYLGYLAAMAESS
                     LKSHYFPKTETETTDAYLDRLVKTLSETTATKRGLVVENDWLAIQLIQKITQVGLSIPD
                     QVAIVGFDNSQASRLLSPKLSTAAQDFYQMGQEAAKVLLQIIHEPDQAVVSCQLPVQVF
                     IRESSH"
     gene            7956..9242
                     /locus_tag="SPY_RS06645"
                     /old_locus_tag="SPy1603"
                     /old_locus_tag="SPy_1603"
                     /db_xref="GeneID:901850"
     CDS             7956..9242
                     /locus_tag="SPY_RS06645"
                     /old_locus_tag="SPy1603"
                     /old_locus_tag="SPy_1603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH125"
                     /protein_id="WP_011285655.1"
                     /db_xref="GeneID:901850"
                     /translation="MTRPIPTSVSQFMAKVESLCGDQHPDWALNFKTSFTNTLETTLKT
                     YEDGTSFLLTGDIPAMWLRDSTAQMKPYLFLAKEDEEIRKIIAGLVKRQFRYICIDPYA
                     NAFNEEANEKGHQTDHTQMNPWIWERKYEIDCLCYPIQLAYLLYRETGSTDQFNDDFHR
                     GVELILDLWTVEQDHAQSPYLFERDTWRKEDTLTHAGKGSPVAPTGMTWSGFRPSDDAC
                     QYGYLIPSNMFAVVVLSYLEDLYNNLFHNEPVATRAKQLKEAIQSGIADHALVQNSKGE
                     TIYAYEVDGLGQFSIMDDANIPSLLAAPYLGFCTKDDPIYLATRRTILSQENPYYYQGN
                     AAAGIGSSHTPENYIWHIALALQGLTALDQDSKKEMLDLLVATDAGTHLMHEGFDVNDP
                     YQYTREWFSWANMMFCELLLDYLGFSIAP"
     gene            9257..11962
                     /locus_tag="SPY_RS06650"
                     /old_locus_tag="SPy1604"
                     /old_locus_tag="SPy_1604"
                     /db_xref="GeneID:901852"
     CDS             9257..11962
                     /locus_tag="SPY_RS06650"
                     /old_locus_tag="SPy1604"
                     /old_locus_tag="SPy_1604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014612488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH38"
                     /protein_id="WP_010922530.1"
                     /db_xref="GeneID:901852"
                     /translation="MATKKVHIISHSHWDREWYMAYEQHHMRLINLIDDLLEVFQTDPD
                     FHSFHLDGQTIILDDYLKVRPEREPEIRQAIASGKLRIGPFYILQDDFLTSSESNVRNM
                     LIGKEDCDRWGASVPLGYFPDTFGNMGQTPQLMLKAGLQAAAFGRGIRPTGFNNQVDTS
                     EKYSSQFSEISWQGPDNSRILGLLFANWYSNGNEIPTTEAEARLFWDKKLADAERFAST
                     KHLLMMNGCDHQPVQLDVTKAIALANQLYPDYEFVHSCFEDYLADLADDLPENLSTVQG
                     EITSQETDGWYTLANTASARIYLKQANTRVSRQLENITEPLAAMAYEVTSTYPHDQLRY
                     AWKTLMQNHPHDSICGCSVDSVHREMMTRFEKAYEVGHYLAKEAAKQIADAIDTRDFPM
                     DSQPFVLFNTSGHSKTSVAELSLTWKKYHFGQRFPKEVYQEAQEYLARLSQSFQIIDTS
                     GQVRPEAEILGTSIAFDYDLPKRSFREPYFAIKVRLRLPITLPAMSWKTLALKLGNETT
                     PSETVSLYDDSNQCLENGFLKVMIQTDGRLTITDKQSGLIYQDLLRFEDCGDIGNEYIS
                     RQPNHDQPFYADQGTIKLNIISNTAQVAELEIQQTFAIPISADKLLQAEMEAVIDITER
                     QARRSQEKAELTLTTLIRMEKNNPRLQFTTRFDNQMTNHRLRVLFPTHLKTDHHLADSI
                     FETVKRPNHPDATFWKNPSNPQHQECFVSLFDGENGVTIGNYGLNEYEILPDTNTIAIT
                     LLRSVGEMGDWGYFPTPEAQCLGKHSLSYSFESITKQTQFASYWRAQEGQVPVITTQTN
                     QHEGTLAAEYSYLTGTNDQVALTAFKRRLADNALITRSYNLSNDKTCDFSLSLPNYNAK
                     VTNLLEKDSKQSTPSQLGKAEILTLAWKKQ"
ORIGIN
        1 ctattccttc accccaccaa tggtcaaacc accgacaaag tacttttgga agaatgggta
       61 agtcaaggca atcggcaagg ttgcaataac cacgatagcc atacgaactg attcttttgg
      121 cagcgatgct aagctatctg ccatttgtgc actcatgcca gcattttgtg ccaaggcctg
      181 taggttgctc tgaattttca tcagtaagta ctgcattggg taaagattct cactttgcac
      241 ataaagcaag gcgttaaacc aatcattcca ataagttaag gcagaaaata aactgatggt
      301 ggcaatccct ggaacagcta atggtaagac aattttcata aaaatcatcc attcactagc
      361 cccatccata cgagccgact caataatgct atctggaact gtctttttaa agaacgttct
      421 catgaccaag atgccaaatg ggcccagagc cattggtaaa atcaaggccc aaaccgtatc
      481 cttcaaatga aggagattgc tgaccaccaa gtaattagca accatccctg gtgcaaagag
      541 catggtgata agtgcataaa cagtaaaaaa acgtctgtat gggaaataag gtcttgaaat
      601 cgcataagca taggttgatg tcatggtcgt gttaataaag gttcccacca ctgtaataaa
      661 cacggatatc ccaaatgacc tcatgattct atgggacatg gctccttgaa aaatatactg
      721 gtaagcctta gttgaccaga catctggaaa aaaactatac ccatgattaa tcaagtaact
      781 ttcatcagtg aaggaaataa taatcacgaa gataaaagga atgatacaag agatggcaaa
      841 cagaccaatc agaatattaa agatagcatt ggtttttcga tcaaaggttc taacattaac
      901 cttttcgact tttttctttt tctccatgtt ttcctcctaa aacaaggctg catcagggtc
      961 catgcgacga acaatcgcat tggtgactaa caagatgctg gtcccaacta ctgactgata
     1021 aaggctagct gccgatgcca tcccaatatc tcctgtagca gtcaaggcat tgtagacata
     1081 ggtatctaac acactggtca cgtcataaag tgggcctgaa ttcttaggaa taacgtagaa
     1141 aagtccgaaa tcagatttaa aaatattacc aatattaatg atcaataaga tagacatcat
     1201 tggcaataat tgtggaatgg tgatgttcct aatttgttgc catttgcttg caccatccac
     1261 catagcagct tcataataag tatcagaaat ccctttgact gaagcatagt agataatgct
     1321 attgtagcct agccccttcc agacactcat gaaaagtaaa atcaagggcc accaagtggg
     1381 attggaatac cacttgattg gatctgctcc acttccggtc aagagctgat taatgaaacc
     1441 tttatccgta tttaaaaagg cagaaacaaa gtattcaata accacccatg ataagaaata
     1501 aggcaataag gacatggtgt gatagacctt aaccgttctc ttatttcgta actcactcat
     1561 gataatggca aaagcaatcg caaagaaaac attaaagagt aagaaaatca cattgtaagc
     1621 aatggtattt ctggtaatca accaagcatc tttggaagca aagaggtatt tgaagttagc
     1681 caaaccaacc caagggctct ccttcaaact ttccataaag ccccctgctg aataatgaaa
     1741 atctttaaaa gcaaccacat tggctaaaac tggaatataa aagaaaaaga tgaaccagat
     1801 gaaacctggt aataccatta ataataaggc ccggtattta atcacatttt tccaaaagga
     1861 tgtctttttg ttggtttgtc ttatcatttc ccaacctccc tttgtgttaa tcacgttata
     1921 gttacagtat atcaagcgct ttcattattt gaaagcaaca aattataggt atgataacac
     1981 aaagtataga atcacttaga aagccttttc attgttgctt aaatctgtca tactaagatg
     2041 agacatgatc gtctattcta ctataataaa ggagaacacc tcatgagctt gttatgtatt
     2101 gatataggag gcacttccct taaatttgcc ctctgtcaca atggccaatt aagccagcaa
     2161 agcagctttc ccactccctc tagtctggaa aagttttacc aattactcga ccaagaagtt
     2221 gctcgttact ctgcttacca tttctcaggt attgccatca gttcacctgg ggcagtcaat
     2281 aaagaaaagg gggttatcga aggcgccagc gctattccct acattcacca ttttaaaata
     2341 caagaggcct tagaagaacg gctacattac cctatttcta tcgaaaatga tgccaattgt
     2401 gccgccttag ctgaagctac cttaggggca ggaaaaggcg ctagtagcct agccatgctc
     2461 gttcttggta ctggagttgg aggaagcttg gtcattgatg gcaagattta ccatggtgcc
     2521 cacttatttg ggggcgagtt tggtttcatg atcatgaacg accgctacca aacctttagt
     2581 cagttaggga cagtggtaaa tatggccaag cgctatagtg caatcgtcaa taacggaaaa
     2641 gattatactg gcaaagctgt ccttgccctc gcagaacaag gagatcccct agcactcaaa
     2701 gaaaggcagg tctttctcca aagtttagcc atcggtattt ttaacattca acacgccttt
     2761 gatcctcaac tgattttaat cgggggtggt gtttcccaag ctgactttct actgtcagcg
     2821 attgaagctg aactagacaa actctaccaa gccgtcgaaa tctccgacct tagaccccaa
     2881 ttagctattt gtcactttaa aaacgaagct aatcttctgg gagctgccat tgatttttac
     2941 caagaacaca aggaggccta accatggacc gctaaatccc tcttatcccc tattgtccct
     3001 aatcgcctct gacatctaca aagacatcct aaaaggattg ctgattagct acaacgatac
     3061 tggctttctg cctaaatgac tctctgctga tgaacacagc ctgatgcctg gtccctttgt
     3121 tgatgtcatt gttgctgacg cttctgttaa aggaattggt catcagttaa tgctcgagct
     3181 attagaagct atgctagtta tcgccaataa gcaaagcctc acttaataac tcactcatat
     3241 agtcccctta tcgtggacag tgacataaca aacagtcact agaaaccata agggactttt
     3301 atctggccca aaaatatgaa agaaaatcct aaaataccaa gatgaaaaac aagcatcctt
     3361 agccaagata ctctaaagaa ttgaagagtc aaattaaaca agatgggtag ttgatgctaa
     3421 accagacaga acgcttatat ctagttcggc aaataccaac actttccaaa gaaatacaag
     3481 agcctcgatc ctcttaacat gaggaaaaag gcccttgttt aatcattggt aacatcatta
     3541 ttcacttgtc tcaaaggaga cgttcacacg ttcaatcact gaggtgagaa gcagagcctc
     3601 caaactcctc cattacttct aatgaaatca agcggttatg agtagctact tttttaaacc
     3661 aataagctga agctttaggt cgtcgcactt gggtatggat attattttcc acaaggccat
     3721 agcggttttt gtaggcattg agccaagacc agccatcaat tggtgtccat acatggtaac
     3781 caaaacaatt cgagcctgct tctattcctt tgtggagata ggttaaatgt tctttcaaaa
     3841 attggatgcg ataatcatct tgaatctgac cagtttcatc acggtaacgg tcttctcctg
     3901 aaatccctac accattttca gataagaacc aaggaatatt gtcgtaatgg tctcgcatct
     3961 tgatggcaat atcatagaca gcctcaggat agatctccca ccccttatcc acgttcatgc
     4021 ggcggccagg catcaggtag ggatcataat accattcagg actccaagat gggctaatca
     4081 ctggaatggc atcaggagcc ttcacgcgct tagggtggta aaaattcaat cccaaataat
     4141 ccactctatt ctcagcaata agagccaact cttctggcgt tgattgccac aaaaccccat
     4201 cttttttcaa taccgcaacc aattcttctg ggaatttccc atgaacagca gcttccataa
     4261 acaagtcatt gttccaaagt tctgcaaaat gcgcagcagc catatccgct tctgattgac
     4321 tagctgggta ggctggcgtc agattgagaa tggttccaat acgcccatca ctaagttctg
     4381 ctggacctcg cctgtaagct tgaataacct tggctgtggc tagggctaga ttataggcga
     4441 cctggactgc ttttttccca tccacgatag cagggtaatg aaattgcatt aaataagagc
     4501 cttccacaac gaccataggt tcattgtgga caaaccaatc cttaacccga tcaccaaact
     4561 gctcaaaaca aaccttgcta aaggcgacaa ataagtccac aacatgcttt gattcccagc
     4621 caccataggc ttgatagagg gcaattggca ggtcaaaatg atgcaaatta ataacaggac
     4681 gaataccatt ggccaagcaa gcatcaatca ctcgattata ataggcaagg ccatcaggat
     4741 taatcgtcgc ttgctcaaag tcatcaatca aacgtgtcca ctgaatggag gtacggtaag
     4801 aattgtgacc tagtgaagct aacaaggtca aatcagattc aatctgatga taggcatccg
     4861 aagccgtatc aggtcccacg taatcgtaaa acaagtcagg ctcctcttca taccaataat
     4921 caaagagatt gcggtgctgc ttagcaaaac gcccctcact ttgagggcct gaggtggctc
     4981 ctccccacca aaactctttt ggaaatgcta acatatcatt cctttctagc tcgtatgcta
     5041 agcatagtct tccggtcttg cttgggtaac ttgaccttga ttagctgtta gtttatcttg
     5101 ctgttgatag tagatgcgat agtaacgact tggaatgtca cttccaatac ggtgtttatc
     5161 ttcttgtaag tcagcataga gtgtttccaa ctgaggctcc tgatttaaca tagcctgcca
     5221 aaaatcttgg tctttggcca cccgttcaaa ccaaggagca atagcttgtt gaaacgctgg
     5281 cttatctagc tttctcaacg tattgacacg ttcgaccaat tcagctaccc aagctgataa
     5341 cgttgataca tccttagcca ggagagcttc ttccacttca aaaggaaggt ccctgtgcag
     5401 atgacgattg ccattatgcc aagcaaatgc ctgtaaagct aaggctaatt cagtatcttc
     5461 tgtatagtct gttaaggttt ctagccaaga atgactaggc tgataacggt tagcatccca
     5521 cagataatgg ctcatatctg tcaaggtaag cttagataat tcccaactaa tcatagggtt
     5581 agaaacaatc cccttgacct gatagtctgg ctggcataaa aatggcgagc gattggcaaa
     5641 aggggttaaa aagagacgtt ctggatcttt ttgataatca ttaacaggaa tattgtccca
     5701 aataatgata ggccgttgat atactgctgc catagtttca atatctgctt gcgagatttg
     5761 actcgctagc gtgcttgggc ctgtccagaa aaaggcgact tctttaggaa tcctttctga
     5821 cagctcttgc aaatagatag aatcatggtg gttgtcgtat tctgtcggac agatcaccaa
     5881 ttctggcgcc gcatgttgtt ggtttaaaaa gtgatgaacc tcagttgcca agtgggcctg
     5941 ggcataggca gtctttttga atcgtctctc aacagcatct acaatttggt agtcaatatc
     6001 atccagcaaa agcccaaaat gacaaacacc taacgctaga agttgttgca atttttgata
     6061 gagcaactga tagtcagctt ccttggtata atcaaaatca agccccggac taatcatata
     6121 ccaaaaatca agcccttctt ccttggctac tgcaagtagc tctttgaaat aagtcaccca
     6181 atcctcagga taaagatcgc gccacagttt tcgttggtaa tcatcatctt taggagcata
     6241 catgtaagta ttcatccttt tatttccaat aaaacgcagg caatctaacc gctcttctcg
     6301 tgtccacggt gttccgtaaa agccttcaat tatcccccgc atagcaaaag aagggctgtg
     6361 cttgacagaa acaatgggca aataaagttt atcccctttg aaggtcatga ctttaagcaa
     6421 agcttcttgg gcgtaacgaa aacctctaag gttttggctt tcaataatga tttccttatc
     6481 ttctgaaatc ttcagggtaa aggcatcctt agccagctga cggttaaaaa agtgtttcat
     6541 cgtcacctct gcttggcctt cttcaatcca ctgaaaatac tttgacgttg ccaattctgc
     6601 cagcagggct ttttgatttt caaagcggaa aaaacggcca ataaatcggc aagtcaatgg
     6661 cgtgtcaaag acaagatagt ctcctcttgt catgacttct tgataatcct ttaaggcgtg
     6721 ataaatggtc atttctggtc tcctttacct gagctaacca gctcatgcta gtaacgtctt
     6781 ttttagtgac tactttctct gataaatact tgaacaggta actggcaaga caccactgct
     6841 tggtctggct catgaataat ctgcaacaag actttagctg cttcttgccc catttggtaa
     6901 aaatcttgag ctgctgtgct taatttggga ctcaacaaac gggaggcttg actattatca
     6961 aagcctacaa tagcgacttg atcaggaata gataagccta cctgtgtgat tttttgaatc
     7021 agctgaatag ccaaccaatc gttttccacg acaagccccc ttttagtggc tgtcgtctcc
     7081 gataaggttt tcaccaaacg gtccaaataa gcatctgttg tttcagtctc tgtcttagga
     7141 aaataatggg attttagaga cgattctgcc attgccgcta agtaacccaa ataacggtct
     7201 ctaacggatg atacttctcc aaaagagcct gttgccacaa aactaatctg gtcacagcct
     7261 tgctcaatca agtgctgagt caattgacag gcaccgcctt tattatccgc tacaacagac
     7321 ggaaactgaa aaagatctag agatttatcc aacaagacta gaggaatgtg atgatggtcg
     7381 cagtaaaaca ggaaatcaat actgtgattg acatcttcag gataataaat aatcccagca
     7441 tagtctgaca gggtgtctaa ccttactgta ctggccaatt gaaccatgag acggtaacct
     7501 gtttcagcaa tggaggtcat aattccctta gcataatctc ccaattcata atcagaagca
     7561 aaaggaagaa tcaacaataa atccttattc gcttcagggg acgtcacttg ctttttagct
     7621 acgaagcttc ctttcccacg acttctcgta atcaagcctt cttgctccag ttctacaagc
     7681 gctcgcttag aagtgatacg gctaaccgag aactgttctg acaattcttt ttcagtaggt
     7741 aggcggtcac caatttgcaa acgacctgat gctatctgct ctttaatgaa atgatatatc
     7801 tttttgtata ataattttgt cattctttac tcctgttatc agtataacat gtcaaaaaag
     7861 agttgtaaac cttttcaaaa acctatagac aaagtttaac ttatcattta taatgaaacc
     7921 gaagataaat gatatatcat tttggaggat atgacatgac acgaccaatc ccaactagcg
     7981 tcagccaatt tatggccaag gtggaaagcc tttgtggaga ccaacaccct gattgggctc
     8041 ttaatttcaa aaccagcttt accaatacct tagagacaac cctaaaaacc tacgaagatg
     8101 gcactagctt tcttttaact ggcgatattc ctgccatgtg gttacgtgat tccactgcgc
     8161 aaatgaaacc ttacctcttc ctcgccaagg aagatgaaga aattagaaag attattgccg
     8221 gtctggtcaa acgccaattc cgctacattt gtatcgatcc ctatgccaat gccttcaacg
     8281 aagaagctaa cgaaaaagga caccaaacag atcataccca aatgaaccct tggatttggg
     8341 aacgcaaata tgagattgat tgcctttgct accctattca actggcttat ctgctctatc
     8401 gtgaaacagg aagcaccgat cagtttaatg acgattttca tcgtggggta gaactcattc
     8461 ttgacctatg gacagttgag caagaccacg cccagtcccc ttacttgttt gaacgcgata
     8521 cttggcgcaa agaagatacc ctaacacatg ctggaaaagg aagtcctgtc gcaccaacag
     8581 ggatgacctg gtcaggcttt agaccaagtg atgatgcttg tcaatatggt tacctcattc
     8641 cttcaaatat gtttgcagtg gttgtgcttt cctatctaga agatttatat aacaaccttt
     8701 ttcacaatga accagtagct actcgtgcca agcagctgaa agaagctatt caatcgggta
     8761 ttgcagacca tgcccttgtt caaaacagca agggagaaac catttacgct tatgaagtgg
     8821 atggtctggg acagttttcc atcatggatg atgctaatat tccaagcctc cttgctgcac
     8881 cttaccttgg tttttgcact aaagatgacc ctatctatct ggcaacgcgc cgcaccattc
     8941 tcagccaaga aaacccttat tattatcagg gaaatgcagc agcaggcatc ggttcttccc
     9001 atacaccaga aaattatatc tggcatatcg cccttgcctt acaaggattg accgctcttg
     9061 accaagacag taaaaaagag atgcttgatt tgcttgtggc aacagatgct ggtacccact
     9121 taatgcacga gggtttcgat gtcaatgatc cttatcaata cactcgtgag tggttctctt
     9181 gggctaacat gatgttctgt gaactacttc ttgactatct gggctttagt attgctcctt
     9241 agaaagtgag gccactatgg caactaaaaa agtacatatt atttcacaca gtcactggga
     9301 tcgcgagtgg tacatggctt acgaacaaca ccacatgcgt ctgattaact taatagatga
     9361 cctgttagaa gtttttcaaa cggatcctga ttttcatagt tttcatttgg atgggcaaac
     9421 cattatccta gatgattatt taaaagtacg ccccgaacga gaacctgaga ttagacaagc
     9481 cattgcttcg ggaaaactcc gtatcggacc tttctatatc ttacaggacg attttttgac
     9541 cagcagtgaa tccaatgtgc gcaatatgct gattggtaag gaagattgtg acagatgggg
     9601 cgctagtgtg ccacttggtt attttcctga tacctttgga aatatgggac aaacaccaca
     9661 gctgatgtta aaagccggcc tacaagctgc tgcctttggt cgtggcattc gtccaactgg
     9721 atttaacaat caggtggata ccagtgaaaa atacagctcc caattctctg aaatcagttg
     9781 gcaaggccca gataacagtc gtattcttgg actcctcttc gccaactggt acagcaatgg
     9841 caatgagatc ccgacaacag aagctgaggc gcgtcttttt tgggataaaa aacttgctga
     9901 tgccgaacgc ttcgcctcaa ccaagcacct tctgatgatg aacgggtgtg atcatcaacc
     9961 cgtacaactt gatgtcacca aggcaatcgc cttagccaac caactctatc ctgactacga
    10021 atttgtgcat tcctgctttg aagattactt ggctgatctc gcagatgatt taccagagaa
    10081 cctttcaacc gtccaaggag agattaccag tcaagaaacc gatggctggt ataccctagc
    10141 taacacggct tctgctcgta tttacctcaa acaggctaat accagagtct ctcgccaact
    10201 cgaaaacatc accgaaccct tagcagcaat ggcttatgag gtaacaagta cctaccctca
    10261 cgaccaactg cgttacgctt ggaaaaccct catgcaaaat caccctcatg attctatctg
    10321 tggttgtagt gttgatagcg ttcatcggga aatgatgacg cgctttgaaa aagcctatga
    10381 agtcggacac tatttagcaa aagaagctgc taagcaaatt gctgacgcca ttgataccag
    10441 ggattttcca atggatagcc aacccttcgt cttatttaat accagcggcc attccaaaac
    10501 aagtgttgct gagctcagcc tgacctggaa aaaatatcat tttggccaac gctttcctaa
    10561 agaggtttac caagaagctc aagaatattt ggcaagactc tcccaatctt tccaaattat
    10621 tgacactagt ggacaagtga gacccgaagc agaaatttta ggcacaagca tcgcttttga
    10681 ctacgatttg cccaagagat ccttccgcga accttatttc gccatcaaag tgagattacg
    10741 gctaccaata actctcccag ccatgtcttg gaaaacctta gcattaaagc taggaaatga
    10801 aacaactcct tcagaaaccg tttccctcta cgatgacagt aatcagtgcc ttgaaaatgg
    10861 gtttctaaaa gttatgatac aaaccgatgg tcgtctaacc atcaccgata aacaatctgg
    10921 actaatctat caagacctgt tgcggtttga agattgtggc gatattggaa atgaatatat
    10981 ttctcgccag ccaaatcatg accaaccttt ctatgcggat caagggacca tcaagcttaa
    11041 catcattagc aacaccgctc aagttgctga acttgaaatc cagcaaacct ttgccattcc
    11101 tatctccgca gataagctct tacaggctga gatggaggct gtcattgaca tcacagaacg
    11161 ccaagcaaga cgttcacaag aaaaggctga gctaacctta acaaccctta tccgcatgga
    11221 gaaaaataat cctcgcctcc aattcaccac acgttttgat aaccaaatga ctaatcatcg
    11281 cttgcgcgtc ctattcccaa cgcaccttaa aacagaccat catctagctg acagtatttt
    11341 tgaaactgtc aaacgtccaa atcatccaga tgccaccttt tggaagaatc caagtaaccc
    11401 acagcaccaa gaatgctttg tgagtctctt tgatggtgaa aatggagtca ctattggtaa
    11461 ctatggcctc aacgaatatg agatcttacc agataccaac accattgcca tcactctctt
    11521 acgttctgtt ggcgaaatgg gcgactgggg ttacttccca acacctgaag cccagtgtct
    11581 tggcaaacac agcctttctt atagttttga aagcatcact aagcaaacac aatttgccag
    11641 ctactggcga gctcaagaag gccaagtccc tgttattacc acacaaacaa accaacacga
    11701 gggaacatta gccgcagaat atagctattt gacgggtaca aacgaccaag ttgccctcac
    11761 agctttcaaa cgtcgcttag cagacaatgc ccttatcacg cgcagctata atctctcaaa
    11821 cgataaaact tgtgacttta gcctaagcct gccaaactac aatgccaagg tcactaattt
    11881 gttagaaaaa gacagcaagc aaagcacacc cagccaactt ggcaaagcgg aaattttaac
    11941 tctagcttgg aagaaacaat aa
//
