LOCUS       NC_016776              10219 bp    DNA     linear   CON 17-FEB-2020
DEFINITION  Bacteroides fragilis 638R, complete sequence.
ACCESSION   NC_016776
VERSION     NC_016776.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA3138381
            Assembly: GCF_000210835.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides fragilis 638R
  ORGANISM  Bacteroides fragilis 638R
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1
  AUTHORS   Patrick,S., Blakely,G.W., Houston,S., Moore,J., Abratt,V.R.,
            Bertalan,M., Cerdeno-Tarraga,A.M., Quail,M.A., Corton,N., Corton,C.,
            Bignell,A., Barron,A., Clark,L., Bentley,S.D. and Parkhill,J.
  TITLE     Twenty-eight divergent polysaccharide loci specifying within- and
            amongst-strain capsule diversity in three strains of Bacteroides
            fragilis
  JOURNAL   Microbiology (Reading, Engl.) 156 (Pt 11), 3255-3269 (2010)
   PUBMED   20829291
REFERENCE   2
  AUTHORS   Aslett,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JUL-2010) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/17/2020 18:16:11
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,439
            CDSs (total)                      :: 4,346
            Genes (coding)                    :: 4,241
            CDSs (with protein)               :: 4,241
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 50 of 105
            Pseudo Genes (incomplete)         :: 48 of 105
            Pseudo Genes (internal stop)      :: 34 of 105
            Pseudo Genes (multiple problems)  :: 24 of 105
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            FQ312004.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Data release policy http://www.sanger.ac.uk/legal/#t_2 DNA source:
            unknown.
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
FEATURES             Location/Qualifiers
     source          1..10219
                     /organism="Bacteroides fragilis 638R"
                     /mol_type="genomic DNA"
                     /strain="638R"
                     /db_xref="taxon:862962"
     gene            complement(1..600)
                     /locus_tag="BF638R_RS06205"
                     /old_locus_tag="BF638R_1323"
     CDS             complement(1..600)
                     /locus_tag="BF638R_RS06205"
                     /old_locus_tag="BF638R_1323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005786040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|GerE"
                     /protein_id="WP_005786040.1"
                     /translation="MAQTLTNLNINDNNAVISALREGDEEVFDHIYRYYFRGLCAFCSQ
                     YVTLSESEEIVQDTMMWLWENRKTLIPELTLKTLLFTIVKNKALNKISHFEIKRKVHQE
                     IAEKYETEFSSPDFYLENELFRLYEEALRKLPAEFRQAYEMNRSLQMTHKEIAEKLNVS
                     PQTINYRIGQALKILRSELKDYLPLIMLFLFLQGHK"
     gene            766..1776
                     /locus_tag="BF638R_RS06210"
                     /old_locus_tag="BF638R_1324"
     CDS             766..1776
                     /locus_tag="BF638R_RS06210"
                     /old_locus_tag="BF638R_1324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009291828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STP|FecR"
                     /protein_id="WP_008768135.1"
                     /translation="MDETKLLNYLKGESDAEECLEVEAWYHASAEHKKQLDQLYYMLFV
                     GERKVAMDGVDTENSLSVLKDRIKHKESEKKSVHRIRVSKWKRYAMPLAAFLCGLLVSV
                     GALYWISSGKSAGYIFATESGQRAQAVLPDGTKVWLNASTQIVYKPSFWKRERQVDLSG
                     EAYFEVSRNKTKPFVVNSNDVRTCVLGTKFNVRARPSEEKVVTTLLKGSVKVQLPGQSE
                     EEGILLKPGQMLSVDTRTMQPMLTEANRPGDVLLWINGKLKFEQATLQEIVQCLEKHFD
                     VHFIISDAQLQKDRFTCTFSTDDDIRQILSILALTKRFDYKCEDNNIILTPKTNR"
     gene            2087..5392
                     /locus_tag="BF638R_RS06215"
                     /old_locus_tag="BF638R_1325"
     CDS             2087..5392
                     /locus_tag="BF638R_RS06215"
                     /old_locus_tag="BF638R_1325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005786045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8A8X1|1.B.14.6.13"
                     /protein_id="WP_005786045.1"
                     /translation="MKKSVKHKFQYLLFFLLSMPAFIFASAQDIRVNIDFTKASLGSVL
                     NEIGRQTSLSIVYNTGDVNPTQPVSIKASNENITTVMNRLLRGTGLSYSIMNKHLILST
                     TDKNHSIQQEKVTVTGNISDAKGEPLIGVSILVKGTSNGTITDMNGHFSLPVAKGDVIE
                     ISYIGYAPQAITVTDSKPLKIVMKEDAEVLDEVVVTALGIKRAQKALSYNVQQVGGDAI
                     NTVKDANFINSLQGKVAGVTINNSAGGVGSASRVVMRGTKSITKDNNALYVIDGIPMFN
                     VSFGKSEGSFATQSGSDGVADLNPDDIESINMLTGPSAAALYGNAAANGVVLINTKKGS
                     AEKTTLTVSNNTMFSDAYMMPEMQNRYGNNPGEFASWGNKTKQSYDPSRFFNTGVNVIN
                     AISFSTGTKKNQTYASASTTNATGILPNNSYSRYNFSIRNTATFLKDRLTLDVGASYII
                     QNDKNITAQGQYFNPLPALYLFPRNDNFEEIRMFERYSESRGVNVQFWPYGHQGLSLQN
                     PYWIMKRMNRKTEKKRYMINASLTYKLTDWLNVAGRVKVDNSDIRMTQERYASTLTTFA
                     GANGFYSDQNRTDRNTYADMMVNIDKRIGDFSLNANIGASIKDLVYEQMGNEGDLAGIP
                     NFFTVRNINYESNYKPKQFGYHDQSQGVFANIELGWRSMAYLTLTGRNDWESQLAFTKH
                     SSFFYPSIGGSVVLSEMFRLPEFISYAKLRGSYSSVASSFERYLSNPGFEFNEQSHQWG
                     SSTTLPATNLKPEDTRSWEIGLNARLWNHFSIDATYYHSNTYNQTFNITLASSSGYSSA
                     IVQTGNIQNYGLELALGYNNTWGDFSWNSSLTYTMNRNKVKRLASGATNPITGEIIDMP
                     ELRMAVLGADGYGPRVILREGGTMGDLYVDKGLRTDGNGNIWVDSQTGKVGVQDYAEPK
                     KIGTMNPDFNMGFSNTFSYKGINLGVVLTARVGGLCVSNTQGILDYYGVSKATADARDA
                     GGVWINNGFVDAKSYYQTIGGSTGGLGQYYTYSATNIRLSELNLSYTLPRKWFNNKVGI
                     TAGIVGKNLWMIYCKAPFDPEMTPSTTSNFYQGVDYFMQPSTRNIGFNVKFQF"
     gene            5405..6949
                     /locus_tag="BF638R_RS06220"
                     /old_locus_tag="BF638R_1326"
     CDS             5405..6949
                     /locus_tag="BF638R_RS06220"
                     /old_locus_tag="BF638R_1326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008659098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8A8X0|8.A.46.2.1"
                     /protein_id="WP_005786046.1"
                     /translation="MKKKILNIVLAAAVTPFLCCCTDNFEEYNTNPYEPHSLNPPMLFA
                     TMITTGINVQQNDNQMIDQMVAGPFSGYLTMANSWGGSNFNTFNQTESWNQIPFNTPFE
                     KFYSNYFKLETATGGKGHYWAMAKLLRVNTMLRVTDCYGPIPYSQVANGKTAVAYDSQE
                     DVYKHMFEDLDYAIQMLGEFVDEVGGLKPLEGYDPVYNGDYNKWMRFANSLKLRLAVRI
                     SNVSPELARTKAEEAVKSTRGLIDTNDNNAYVGVGAEPNPLWLVASSWGEIRINATIAS
                     YMKGYSDPRSAVYFTTSKLGGDSPYMGMRSGLEGVKPATYSGYSMPNYEQKDDMLMFCA
                     AETAFLRAEGALRGWDMGGSARDFYEQGVKLSFDQRKVSGADEYLANAVAVPEPFVDPV
                     NPAKCNYTPKTKITIAWNEGASTEEKLERIITQKWIANFPLGFEGWADYRRTGYPEVFP
                     SVSNLSNGVIDTNRQLRRLPFPLSEKQGNSANVSAAVSMLGGPDTGATDLWWAKKN"
     gene            6977..8029
                     /locus_tag="BF638R_RS06225"
                     /old_locus_tag="BF638R_1327"
     CDS             6977..8029
                     /locus_tag="BF638R_RS06225"
                     /old_locus_tag="BF638R_1327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008659099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH18"
                     /protein_id="WP_005786048.1"
                     /translation="MKKRYLNIVVFALFVSMLWGCSDWTKPEAEDFFEMPGNDYYENLR
                     AYKRSEHSVAFGWFGGWTGVGASMVGSLMGLPDSVDFVSIWGNWKNLDEARMLDKKKVK
                     EQKGTRALMCFIVANVGDQLTPEEHKENYKEYWGWKDGDQEAIDGAIRKYANAICDSID
                     KYGYDGFDIDYEPNYGSPGNLASYPENMLTFVKALGERIGPKSGTGRLLVIDGEPQSIH
                     PETGPYFDYFIVQAYSNLAGNSDANLDRRLAGTIANFKGILPPEKVANMYIVTENFESY
                     APTGGGDYVDRYGNKMRALAGMARWTPTIDGKQVRKGGVGTYHMEYDYPGDIEYKYLRE
                     AIRIMNPAVK"
     gene            8047..9183
                     /locus_tag="BF638R_RS06230"
                     /old_locus_tag="BF638R_1329"
     CDS             8047..9183
                     /locus_tag="BF638R_RS06230"
                     /old_locus_tag="BF638R_1329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008768137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1735 domain-containing protein"
                     /protein_id="WP_014298454.1"
                     /translation="MKRITIKQCLFACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
     gene            9206..10219
                     /locus_tag="BF638R_RS06235"
                     /old_locus_tag="BF638R_1330"
     CDS             9206..10219
                     /locus_tag="BF638R_RS06235"
                     /old_locus_tag="BF638R_1330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008768138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1735 domain-containing protein"
                     /protein_id="WP_005800908.1"
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
ORIGIN
        1 tcatttatgc ccttgcagaa ataaaaacaa catgatcagc gggagataat cctttagttc
       61 ggaccgtaat attttcaggg cttgccctat acgataattg attgtttgcg gagagacgtt
      121 cagtttctcc gcaatttctt tatgagtcat ttgaagactt cgattcattt cgtatgcctg
      181 gcgaaattcg gccggtagtt ttcttaaagc ctcttcgtac aatctgaata gttcgttttc
      241 caggtaaaag tcaggtgaag agaactccgt ttcatatttt tccgcaattt cctgatgcac
      301 cttgcgtttt atttcaaaat gagagatttt attaagcgct ttgttcttga cgatagtaaa
      361 gagaagagtc tttaaagtaa gttccggtat aagggttttt ctgttttccc atagccacat
      421 catagtatcc tgcacgattt cttccgattc gctcagagtg acatattgag agcaaaaggc
      481 gcataatcca cgaaaatagt aacggtagat atgatcaaac acctcttcat ccccttctcg
      541 cagggctgat ataacggcat tattatcatt tatgtttagg ttagtcagag tctgtgccat
      601 tcttctctcc attgttatta gcgaacaaac gtagctaaat ttttgctacc tacaaaatga
      661 ttttctgaag aaaaaaaagt ttgtgtttta tttagtaact ttgttttctg aactgtatta
      721 tacgtaacag tgtatgatat aggtattaaa gatttggtta aaacaatgga tgaaacaaaa
      781 ctactgaact atctgaaagg agaatcagat gccgaagagt gtctggaagt ggaggcatgg
      841 tatcatgctt ctgcagaaca caaaaaacaa ctggaccaac tttattatat gctttttgtc
      901 ggtgaacgta aggtggcaat ggatggtgtg gacaccgaaa attcactaag cgttttgaag
      961 gaccggataa agcacaaaga gtcagagaaa aaatcagtgc atagaatacg tgtatcaaaa
     1021 tggaaacgtt acgcgatgcc tttggcagct ttcctgtgcg gtctgttggt gtctgtcggt
     1081 gccctatact ggatttcctc cggaaagtcg gcaggatata tttttgctac cgaatcaggg
     1141 cagcgggcac aggcagtttt accggatgga acgaaagtat ggttgaatgc ttcaacacag
     1201 atcgtctata agccttcttt ctggaagcgg gaaagacagg tcgacttgag tggtgaggct
     1261 tattttgagg tatcacgtaa taagacaaaa ccctttgttg ttaatagtaa tgatgtcagg
     1321 acttgcgtgc tcggtacaaa attcaatgtc cgggcacgtc cgtccgaaga aaaggtggtg
     1381 accactttat tgaagggatc agtaaaagtc caattgccgg ggcagtctga agaggaaggt
     1441 attttgttga agccgggaca gatgctgagt gtggataccc gtacgatgca acccatgctt
     1501 acagaagcca accgtccggg agatgtattg ctatggatta acggaaaact gaaattcgaa
     1561 caggccacac ttcaggaaat agtgcagtgt cttgaaaaac attttgatgt tcatttcatt
     1621 atttcggatg cacaactgca aaaagaccgt tttacctgta cttttagtac ggacgatgat
     1681 ataagacaaa ttctttctat actcgctctt accaaacgtt tcgattataa atgtgaggat
     1741 aacaatataa tattgactcc taagacgaat agataacaaa aatattttat aacctaaatc
     1801 acgaagaggg ggctgtttct gtaaagaaat agttcccttt ttttatcttc tgatctgtat
     1861 tcttattctt tttttattct tttttcgaaa aaatccgctt cttgatttag tatgtttata
     1921 agttgaaatg tactattaac agaaaagaga tatagttaac ctaaaaatct gtagtgatga
     1981 ataatgaccc ttaatttaaa accaacctta acatgtatta gcgatccttt atgctaaacc
     2041 tttcaatttt acctaaaaac attttctaat taaaaaaaag aacaagatga agaaatcagt
     2101 gaaacacaag tttcagtact tgctattttt tctattgtcg atgcctgctt ttatctttgc
     2161 ttcagcgcaa gatatacggg tgaatatcga ctttaccaaa gcctctttgg gcagtgtcct
     2221 gaatgaaata ggacgtcaaa cctcattatc tattgtgtat aacaccgggg atgttaaccc
     2281 cactcaacct gtttctatca aggcttctaa cgaaaatatc acgacggtca tgaaccgtct
     2341 gcttcgtggg acgggacttt cctattctat tatgaacaaa catcttattc tttcgaccac
     2401 tgataagaac cattcgattc aacaggagaa agttacggtc acgggaaata tttcggatgc
     2461 caaaggcgaa ccactgatcg gagtgagtat tctggtgaaa ggaacatcga acgggacaat
     2521 taccgatatg aacgggcact tttccttgcc ggttgcgaaa ggagatgtta ttgagatctc
     2581 ctatatcggt tatgctccgc aggccattac ggtgacagac tccaagcctt tgaagattgt
     2641 tatgaaagaa gacgcagaag tgcttgacga agtggtagtg actgccttgg gtatcaagcg
     2701 ggcgcaaaag gcgttgagtt acaacgtaca gcaagtaggt ggtgatgcta tcaatacagt
     2761 aaaggatgct aactttatca actctttgca aggtaaggtt gccggagtaa caatcaataa
     2821 ctcagctggt ggagttggtt ctgcttcgag agtcgtgatg cgcggtacca agtccattac
     2881 gaaagataat aatgctcttt atgtaattga cggtattccg atgttcaatg taagctttgg
     2941 taagagtgaa ggttcttttg ccacccaaag tggttcggac ggagtagcgg atcttaaccc
     3001 ggatgatatt gaaagtatca atatgctgac cggtccttct gcggcagctt tgtatggtaa
     3061 tgcggctgcc aatggagtcg tattgatcaa taccaagaaa ggatcggccg aaaagacaac
     3121 tctgactgtc agcaataata cgatgttctc tgacgcatat atgatgccgg agatgcaaaa
     3181 ccggtatgga aacaatccgg gagaatttgc aagctggggc aataaaacca agcaaagcta
     3241 tgatccttcc cgtttcttta ataccggagt gaatgtaatt aacgctattt ctttttcgac
     3301 cggaacaaag aaaaaccaga cctatgcgtc ggcttcaaca accaatgcga caggtatttt
     3361 gcctaataac agttatagcc gctacaattt ctctatccgg aatacggcca cttttctgaa
     3421 agataggctg actctggatg taggtgccag ctatatcatt cagaatgaca agaatataac
     3481 ggcacaggga caatacttca acccgctgcc ggcactctac ctctttcccc gtaacgacaa
     3541 ttttgaggag atccgtatgt tcgaacgata tagcgaaagc cgtggagtga acgtacagtt
     3601 ctggccttac ggacatcagg gattaagttt gcaaaatcca tattggatta tgaaacgcat
     3661 gaaccgcaag acagaaaaga agcgctacat gattaatgca agcttaactt ataagctcac
     3721 ggattggctc aatgtagccg gacgtgtcaa ggtggataat tccgatattc gcatgactca
     3781 ggaacgttat gcatctactc tgactacctt tgccggtgcc aatggtttct attccgatca
     3841 aaatcgtacg gaccgcaata cgtatgccga tatgatggta aacattgata agagaatagg
     3901 ggacttctcg ctgaatgcca atatcggtgc gtctatcaag gatttggttt acgaacaaat
     3961 ggggaatgaa ggtgatttgg cagggatacc taacttcttt acagtgagaa acatcaatta
     4021 tgaaagcaat tataaaccta aacagttcgg atatcatgac caatctcagg gtgtatttgc
     4081 caatatagag ttgggatggc ggagcatggc atatctgacc ctgaccggac gaaatgactg
     4141 ggagtcccaa ctggcattta ccaagcattc ttcattcttt tatccttcca tcggaggttc
     4201 tgtcgtttta tccgagatgt tccggttgcc cgagtttatt tcttatgcaa agctacgtgg
     4261 ctcatacagt tctgtggctt catcttttga acgttattta tcgaatccgg gttttgagtt
     4321 caatgaacaa tcccatcagt ggggatcttc aaccactctg cctgccacca acttgaagcc
     4381 ggaagatacc cgttcgtggg agatcggttt gaatgccaga ctgtggaatc atttcagtat
     4441 agatgccact tactatcatt cgaataccta taaccagacc tttaatatca ctttggcatc
     4501 gtcgagtggt tattcttcgg ccattgtaca aacgggtaat attcagaatt acggtttgga
     4561 gttggcgtta ggatacaata atacatgggg agactttagc tggaacagta gtctgactta
     4621 tacgatgaat cgtaataaag tgaaacgtct tgccagcggt gctacgaatc cgataaccgg
     4681 tgaaattatc gatatgcccg aactgcgtat ggctgtgctg ggtgccgacg gatatggccc
     4741 cagagttata ttgagagagg gcggaacaat gggagacctc tatgtggata aagggttgcg
     4801 tacagacggt aacggtaata tctgggtaga ttctcagaca ggcaaagttg gagtgcagga
     4861 ttatgccgaa ccgaagaaaa ttggtacgat gaatcctgat ttcaacatgg gattcagcaa
     4921 tacattctct tataagggca tcaatctggg agtggttctg actgctcgtg tcggtggatt
     4981 gtgcgtctcg aacactcagg gtatacttga ttattatggt gtgtccaaag ctacagccga
     5041 cgctcgcgat gccggaggag tatggatcaa taacggattt gtagatgcca aatcttatta
     5101 tcagaccatc ggtggttcta ccggagggtt gggacagtac tatacttata gtgcaacgaa
     5161 catacgattg tccgaactga acctaagcta cacgttacct cgtaaatggt ttaataataa
     5221 agtaggcata acggcaggta tcgtagggaa gaatctttgg atgatttatt gtaaagcacc
     5281 gttcgatccc gaaatgacac cttccactac cagtaacttc tatcagggag tagattactt
     5341 tatgcaaccg agtacacgta atattggctt caatgtcaaa tttcaatttt aaaaccagtc
     5401 gatcatgaaa aagaaaatat taaatatagt tttggccgca gctgtcacac ctttcctgtg
     5461 ctgctgtacc gataattttg aggagtataa taccaatccc tatgaacccc attcactcaa
     5521 tccgcccatg ctgtttgcaa ccatgattac taccggaatc aatgtacagc agaatgacaa
     5581 tcagatgatc gatcaaatgg tagccggacc tttcagtggt tatcttacga tggccaactc
     5641 atggggtggg tccaacttca atacttttaa tcagacggaa tcctggaatc agattccttt
     5701 caacacaccc tttgaaaaat tctattccaa ttacttcaag ttggagactg cgacaggtgg
     5761 aaaaggccac tattgggcga tggcaaaact ccttcgtgtg aatacaatgt tgcgtgtaac
     5821 cgattgttac ggtcccattc cctacagcca ggtggccaat ggtaaaacgg ctgttgccta
     5881 cgatagccag gaagatgtgt ataaacatat gtttgaagat ctggattatg caatacagat
     5941 gttgggtgaa tttgtagatg aagtgggggg actgaaaccg ttggagggtt atgatccggt
     6001 ctataatggt gattataata aatggatgcg ttttgctaat tcacttaaac tgcgtttggc
     6061 tgtccgcatc agtaatgtgt cccccgaact tgcccgtacg aaagccgaag aagcggtaaa
     6121 gagcacccgc ggactgatag atacgaacga taataacgcg tatgtcggtg taggtgccga
     6181 gcccaatcct ctttggctgg tggcctccag ttggggagag atccgtatca atgccactat
     6241 agccagttat atgaaaggat attccgatcc tcgcagtgca gtctatttca ccacctccaa
     6301 gttgggaggc gatagcccgt atatgggtat gcggtcaggg ttggaaggag tgaagccggc
     6361 aacttattcg ggatattcca tgcccaatta cgaacagaaa gacgacatgt tgatgttttg
     6421 tgcggctgaa accgcctttt tgcgtgctga aggcgccctg cgtggttggg atatgggagg
     6481 tagtgcccgt gacttctacg agcaaggcgt taagctatca ttcgaccaac ggaaagtgag
     6541 cggggcagac gaatatctgg ccaatgcagt ggctgtgcct gaaccttttg tcgatccggt
     6601 aaacccggct aaatgcaatt atacaccgaa aaccaagatc acgattgcct ggaacgaagg
     6661 tgcttcgacg gaagagaaac tggagcggat cattactcag aaatggattg ctaacttccc
     6721 tctgggcttt gagggttggg ccgactatcg gcgcacaggt tatccggaag tgtttccatc
     6781 tgtcagcaat ttgagtaatg gagtgatcga caccaatcgg caattgcggc gtttaccttt
     6841 tcccttgtcc gaaaaacagg gaaattcagc caatgtttcg gctgccgttt caatgttggg
     6901 tggtccggat accggagcta ccgatctttg gtgggctaaa aagaattgat gtttaagcta
     6961 ataaagagaa aagaaaatga aaaagagata tttaaatata gtagtttttg cattgttcgt
     7021 cagcatgctt tggggttgca gtgactggac caaacctgaa gcggaagact tttttgaaat
     7081 gccgggaaat gattattacg agaatctgag agcatataaa cgttcggagc attcggttgc
     7141 attcggttgg tttggaggct ggacgggtgt cggggcttcg atggtgggca gtctgatggg
     7201 gcttcccgat agtgtggact tcgtttcgat ttggggtaac tggaaaaatc ttgatgaggc
     7261 ccggatgttg gacaaaaaga aggtgaaaga acagaaaggt acacgcgcct taatgtgttt
     7321 tatcgtggct aatgtaggcg atcagttgac tccggaagag cataaagaga attataagga
     7381 gtactggggc tggaaggatg gtgatcagga agctatcgac ggtgctatca gaaaatatgc
     7441 gaatgctatt tgtgactcca ttgataagta tggatacgat ggtttcgaca tcgattatga
     7501 acctaattat ggttctcccg gaaacttggc aagttatccc gagaatatgc tcactttcgt
     7561 gaaagcactg ggagaaagaa tcggacctaa atcgggtacg ggacggttac ttgtgattga
     7621 tggcgagcct caaagtattc atccggaaac cgggccttac tttgactatt tcattgtgca
     7681 ggcatactct aaccttgcgg gtaattccga cgctaatctt gacagacgtc tggctggtac
     7741 gattgccaac tttaaaggaa tacttcctcc ggagaaagtg gctaatatgt acatcgttac
     7801 ggagaatttc gaatcttatg ctccgacagg aggaggtgat tatgtagatc gttacggaaa
     7861 caaaatgaga gcacttgccg gcatggcacg ctggactccg actattgacg gaaaacaggt
     7921 acggaagggt ggagtaggca cctatcacat ggaatatgac tatccgggcg acatcgaata
     7981 taagtacctg cgtgaagcaa tcagaataat gaatcctgct gtaaaatgac tttaaagaat
     8041 ttgattatga aaagaataac aataaaacaa tgtttgtttg cctgtttcgt tctgccgatg
     8101 atcctggcag gatgcaacga tgccgattac caggttatcg acaatgcgat ttatttgaat
     8161 gaagcatccg agaatggttc ggcaaaggtt accgttgatc ctgaaaatgt aacaacaact
     8221 actctgaccg tacgtgtggg acagcctgta accgaaaatg tgactgctgt cctgacggta
     8281 gatccttcta ttcttaaaga gtacaatgaa gctaatgaaa cttcgtacga agtccttccc
     8341 gagcagtatt ttacttatga caaagagata aagatagcgg caggcgatgt tagcgcaatc
     8401 cccagtgagt ttagagtgaa accttattca aacgagaacg gagaattgta tgctattccg
     8461 gtatctctca cagaaattca gggaccggtg tctacaatcg ggctttcgtc gaagtttatc
     8521 attttgctgg ataagccgct gatacagtct gtaccgttta tgaatacgac caatgccgtg
     8581 aagcccgcca aggacgaatt gtggggagtg acaaccaatg aatggtcact cgaggcttgg
     8641 gtacagatgg acggattcga tattaataat caggctatat ttaattcggg cagcagcgac
     8701 cacgaggttt atatccgttt cggtgacgct atgatccctt ataattcatt acaggtgaag
     8761 acacttggaa gtcaggtcaa tacggtgact ttgtttgaga agaataagtg gtatcatctg
     8821 gccttcgttt ataattcttc cgggttattg tcgatttata tcaacggagt gctcgacgtg
     8881 actctgcaga caaagggtgg cccggtaaga ttcgacaaga tgaacatggt ttcgagcggt
     8941 agttacttcc gcaacaattg tcagatggcc caggtgcgtc tttggaagag cgcaatcagc
     9001 cagacgcaaa ttcagtccaa catgtatttt gccgtgaaac ccgccgatcc gaacctgata
     9061 ggctattgga aaatggatga aggtaaggga aatgcctttg ccgactgtac cggacacgga
     9121 tacgatttgg tggcaggagg aactcttgtc tggaaagagc atgttcgttt tgataagcaa
     9181 taactatgta aaaagaagat aagatatgaa tagacatttg aattttgtga ccttaatctg
     9241 cctgataaca ggctttgtat cgttggcttc gtgcagcaac gatgatgatg aaatggacaa
     9301 atatcaaaag atatatatca gaacgggagt tgcaccgggg gccgaaatgg gtgctgcggt
     9361 agtggtggat tgtgtgagca attcctctac tgctgaccgt tctgattttg aaatacaatt
     9421 gtgtgccgta cagccggtta cgcgggatgt cactgccgct ttgggagtag atacgctgaa
     9481 agtggatact tacaattctg ccaataagac gaaatgtaag ttgttgcccc aagataatta
     9541 taccattgaa acaagtgaag ttgtcttaaa aacgggacag acagtggccg attcatcttt
     9601 tcaggtcgtt ttgaagaata tagaaaagtt gactaatcct gacggatatg tgcttcccgt
     9661 gacgcttaaa ggagttacgg gcatggacga acaggctgtc agtacatcta tgaagacggt
     9721 ttatatccgg atttatacca gcgtgcttta taccagttat acgaaacccg ggaattggtc
     9781 cgctgtagat cgaagtgcgt ggagtgtaag ttgcagtaat gtttatgccg atgatgatgc
     9841 caaatatggt gcacatctgg ctattgacgg tgagataaat actacttggt ttacatgggg
     9901 agtggctaat gccggagagt gttggtggaa tacggtactg gaccggcctg ttaccttaac
     9961 cggattttcg gtcactaaac agagtgccta cggatcgggt tataacctga gaagtgctga
    10021 gattaaggtt cggaaagagg gtgaaaccga gtgggttact tacccgagag tcttgacttt
    10081 cagaaatttt aaaggggctg atccgcaata tgcggccatc gaaccaccta tcccgaatgt
    10141 aaaggaattc agaataaact gtctgactcc ggataattat accgggtttg ctgagataaa
    10201 tttatatgtg aagcaatag
//
