LOCUS       CP012801               14851 bp    DNA     linear   BCT 16-OCT-2015
DEFINITION  Bacteroides cellulosilyticus strain WH2, complete genome.
ACCESSION   CP012801
VERSION     CP012801.1
DBLINK      BioProject: PRJNA289334
            BioSample: SAMN03852682
KEYWORDS    .
SOURCE      Bacteroides cellulosilyticus
  ORGANISM  Bacteroides cellulosilyticus
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1  (bases 1 to 14851)
  AUTHORS   Wu,M., McNulty,N.P., Rodionov,D.A., Khoroshkin,M.S., Griffin,N.W.,
            Cheng,J., Latreille,P., Kerstetter,R.A., Terrapon,N., Henrissat,B.,
            Osterman,A.L. and Gordon,J.I.
  TITLE     Genetic determinants of in vivo fitness and diet responsiveness in
            multiple human gut Bacteroides
  JOURNAL   Science 350 (6256), AAC5992 (2015)
   PUBMED   26430127
REFERENCE   2  (bases 1 to 14851)
  AUTHORS   McNulty,N.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2015) Center for Genome Sciences and Systems
            Biology, Washington University School of Medicine, 4444 Forest Park
            Ave., Saint Louis, MO 63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method       :: HGAP 2.0 and Celera v. AUG-2014
            Assembly Name         :: B_cell_WH2_2.0
            Long Assembly Name    :: Bacteroides cellulosilyticus WH2 2.0
            Genome Coverage       :: 209x
            Sequencing Technology :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..14851
                     /organism="Bacteroides cellulosilyticus"
                     /mol_type="genomic DNA"
                     /strain="WH2"
                     /isolation_source="stool sample"
                     /host="Homo sapiens"
                     /db_xref="taxon:246787"
     gene            1..3405
                     /locus_tag="BcellWH2_04902"
     CDS             1..3405
                     /locus_tag="BcellWH2_04902"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF07715.9"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q45780|1.B.14.6.1"
                     /protein_id="ALJ62111.1"
                     /translation="MKKEEIFSRKTQSRYLSAAKIICLSFLFSIPVTQAFAESIRETAA
                     MNVVQQQKSVKGTVVDTTGEPVIGANIKAQGTDTGTITDLDGNFSLVIPASAKLEVSFI
                     GYVTQVVSVPANGIVNVTLAEDSKLLDEVVVVGYGTQKKAHLTGSISTVNPNDLKEMPY
                     SNMGAMLAGTVAGLNVSGGDGRPGVGATMTIRDPFSTGVSGSTTAPIYVIDGVIQSDNP
                     RNGISASEAFNNLDPNEIESISILKDAAAAVYGARGAQGAIIVTTKKGSKDGKPRISYT
                     GSVTMNDEISRPKMLDAYQYGQFWNGFKGADGNDAIGNRKKDLFQLDELEAMKSMNYDW
                     LDKAWSAAYSTKHNVNISGGGNNSSYFGSISYQSQEGNLSMLDYDRWNYRVGMSTTVAK
                     HLKVNLSISGNYGDRKTTFNKIGGEKDDNDYLALLTTPRYVPWSVENDKGEDIWLLRYG
                     PKNTNSSVLGNSNYLRYNYFAVEDLGNQKQTKTQDMTINGSLEYDFDWLETLKGLKLRF
                     SYAKSIGNTEGRQLGSKYNGYYFTTRGGSGNHLYIDEGAPSNNLTLPSNMKTQSVDNGN
                     RVLRDFDRTDNYQVNFQASYARDFGKHSVSAMFAMEKREMNYEFSRILKEGPLNGDLAN
                     GETNTATGSVSSSSQTARSESGDLSYIGRVNYAYDGRYLFEFLIRSDASTKFSPDNYWG
                     VFPSVSVGWIVSEEKWYKLDWMDYLKVRASFGILGQDNTAAWLWRQRYTYQANYGAIFG
                     TSPSNNLGWALKTEAAPNYDAHWDKDYKFNLGIDMKFLKNRLSVGIDAYLDKRTDMLVV
                     RSGVPVTVGAKSAAENFDAVDNYGVELSLGWRDHVSDFNYSVQLNGQWRDARYRKKDWP
                     AISTYKDVYRNGPVDMGQWGYDCLGMFRNQAEIDKFVEDYNITQYMGYKPDQIKPGMLI
                     YRDVRGEQNPDGSYKDADGIVDDKDMVRLSRRKSNPYGMSLILGGSWKGISLNANISSS
                     WGGYSTYAGGSYIFMNENSLDGANLPIYWKDMFVPEDVVDDGGNVVVKQNLSAKYPNMK
                     YSMNNEASNFWQISSFRMYLRNVSLGYTLPKEWLSKIGISSCKINVTGTNLFSFFNPYP
                     ESYTDPLTGYGTFPALRSWTVGLNLSF"
     gene            3435..5516
                     /locus_tag="BcellWH2_04903"
     CDS             3435..5516
                     /locus_tag="BcellWH2_04903"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF07980.5"
                     /codon_start=1
                     /transl_table=11
                     /product="SusD family protein"
                     /protein_id="ALJ62112.1"
                     /translation="MKIDNIIHKGVGIVAFSAIFLLGSCSDDFLREKKDYNGFNDEIYS
                     NFSMAQASVDYIHRQVEPKVGGVSALNGSTGSADEFSKSTLEYAGSTQFVGLAEILSSN
                     VNCYFNGSNDPANNNGVWLNVRRCNLFLDNIDKGTLSEEERNLLKGQVYFWRAWLYYRL
                     VTTYGGVPIIKSAQNPTIGDGTIEESTLNVERSSTDDCVTFVCEDLDNAASLLPSVWAD
                     PSVNYGRVTKGAAMALKGRLLLFYASPLFNRSNDKARWDAAYTANKAAYDELTTNGDRE
                     LVGATSKRAQDWEKMFVNPLSKEAVLITLYNNISDDQFKFNNSWEQSARPKDIKGGGGI
                     AATAEMVDLFPMADGKKPGESSLSYDPLKFYKDRDPRFYRTFAFNGVCWPYNTNKTYTV
                     WNYQWFKDAAAAVEGKPGNSALYDGDVSSSIFVRKRTDPNAYNTSNLSSGVFSQSSSPY
                     MEIRMAEVILNVAEAACGKGDNATALTFLKYIRERVGYTGDCGFSSTLAGDALMGAILY
                     ERQIELAYEGKRFDDMRRWLLWDDSFGTCTRLGVEPISGNQTRRHGIILAVKPELYTNS
                     KAGKDCDPFNPEASEYLGTSDRTKISLDPDASDSDWENQIATLDNFYENNLNRVVNDQL
                     DGTSTPTFYITHLNKYYFLGIKQNVLQNSIKLQQNIGWTDYYGSEGTFNPIGNGSLLP"
     gene            5697..7424
                     /locus_tag="BcellWH2_04904"
     CDS             5697..7424
                     /locus_tag="BcellWH2_04904"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /codon_start=1
                     /transl_table=11
                     /product="PL1_2|CE8|PL1"
                     /protein_id="ALJ62113.1"
                     /translation="MKKKAFLIVCTAAMLAPTIAWAQYPQLTDEAKETYKKMITEERRR
                     SDEAWAKALPIVEKEAREGRPYIEWASRPDDLPQAGIPAFPGAEGGGMFTPGGRGGKVI
                     TVTNLNDRGPGSFREACETGGARIIVFNVAGIIRLESPIIVRAPYVTIAGQTAPGDGVC
                     IAGESFWVDTHDVVVRHMRFRRGETKVHHRDDSFGGNPIGNIMIDHCSCTWGLDENISF
                     YRHMYSPGEGYKDEKLPTVNVTIQNTISAKALDTYNHAFGSTLGGENCAFMRNLWASNA
                     GRNPSIGWYGIFNFVNNVVYNWVHRSADGGDYRAMFNMINNYYKPGPLTPRDSPVGHRI
                     LKPEAGRSKLDYKVYGRVFADGNVMEGYPEITKDNWAGGIQIETQKDTEGYTEQMRTYQ
                     PFVMPYINIMSANDAYDYVLKYVGANIPCRDIVDERVIEEVKTGQAYYEKKLPKDAYGD
                     KWGLAPKSQDEEGYFKYRRLPKDSYKQGIITDIRQMGGYPEYKGTPYVDTDGDGMPDEW
                     EIANGLNPNDPSDANKDCTGDGYTNIEKYINGISTKNKVDWTDMKNNYDTLAEKGKLM"
     gene            7424..8098
                     /locus_tag="BcellWH2_04905"
     CDS             7424..8098
                     /locus_tag="BcellWH2_04905"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="ALJ62114.1"
                     /translation="MSMKKIILISLLLVFGWLSAGAVDLNKDNRDPQYVESIVKRSQKI
                     VDKLGLTDVKVAEDVRNVIANRYFELNDIYEVRDAKVKKIKESGLSGAAKDDALKAAEY
                     EKDAALYRSHFAYPANLSLFLDEKQIEVVKDGMTYGVVKVTYDATIDMIPSLKEEEKAQ
                     IYAWLIEAREFALDAENSDKKHAAFGKYKGRINNYLAKRGYDLTKEREEWYKRVKARGG
                     SL"
     gene            8281..9210
                     /locus_tag="BcellWH2_04906"
     CDS             8281..9210
                     /locus_tag="BcellWH2_04906"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF04616.8"
                     /codon_start=1
                     /transl_table=11
                     /product="GH43_18|GH43"
                     /protein_id="ALJ62115.1"
                     /translation="MRKLRNTLAAISILFLASCGGNKDYYMFTSFHEPANEGLRYLYSE
                     DGMHWDSVPGVWLKPELGQHQLMRDPSMVRTPDGTYHLVWTTSWKGDLGFGYAYSKDLI
                     HWSEQQMIPVMAHEPTTVNVWAPEIFYDDEAEQFMVVWASCVPGRFEKGIEEEKNNHRL
                     YYITTKDFKTISETKLLYDPGFSSIDATIIKRAKNDYVMVLKDNTRPERNLKVAFADSL
                     TGPYSPASQPFTESFVEGPSVEKIGDDYLIYFDVYRKKIYGAVRTRDFRNFTDETGNVS
                     VPTGHKHGTIFKAPESLVKELLKESKKK"
     gene            9232..12555
                     /gene="hypBA2"
                     /locus_tag="BcellWH2_04907"
     CDS             9232..12555
                     /gene="hypBA2"
                     /locus_tag="BcellWH2_04907"
                     /EC_number="3.2.1.187"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:E8MGH9"
                     /codon_start=1
                     /transl_table=11
                     /product="GH142|GH143"
                     /protein_id="ALJ62116.1"
                     /translation="MNSPIKILFVLATGWLTLTSASAQDRIHYTGTELSNPTYHDGQLS
                     PVVGVHNIQLVRANREHPDASNGGGWTYNHQPMLAYWNGQFYYQYLADPSDEHIPPSQT
                     FLMTSKDGYNWTNPEIVFPPYKVPDGYTKTSRPGMQAKDLIAIMHQRVGFYVSKSGRLI
                     TMGNYGVALDKKDDPNDGNGIGRVVREIKKDGSFGPIYFIYYNHGFNEKNTDYPYFKKN
                     KDREFVKACQEILDNPLYRMQWVEEADREDPIIPLKKGYKAFNCYTLPDGRIVSLWKHA
                     LTSITEDGGYTWAEPVLRAKGFVNSNAKIWGQRLTDGMYATVYNPSEFRWPLAISLSKD
                     GLEYTTLNLVHGEIPPMRYGGNYKSYGPQYPRGIQEGNGIPADGDLWVAYSVNKEDMWV
                     SRIPVPVQIQASAHADDDFSKAGSIAELTDWNIYSPLWAPVTLDGKWLRLQDKDPFDYA
                     KVERKIPASKELKISFDLQAGQNDKGTLQIDFLDENSIACSRLELTPDGIFRAKGGSRF
                     GNLMKYEPGKNYHVEAILSVTDRNIQVFVDGKRVGLRMFYAPVPAIERIAFRTGVPRIF
                     PTVDTPADQTYDLPNAGDQEPLAEYRIANVKTSSVDKDATAAVLEYADFSHYADYFNGM
                     EDENIAQAIPNAKASEWMEENIPLFECPQRNFEEMYYYRWWSLRKHIKETPVGYGMTEF
                     LVQRSYSDKYNLIACAIGHHIYESRWLRDPKYLNQIIHTWYRGNDGGPMNKMNKFSSWN
                     ADAVLARYMVDADKDFMLDMKENLEAEYQRWECTNRLQNGLYWQGDVQDGMEESISGGR
                     KKKYARPTINSYMYGNAKALSLMGILSDDEGMAMRYGMRADTLKRLVQDKLWNSRHQFF
                     ETMRADSSANVREAIGYIPWYFNLPDTVKQYEVAWKEIMDENGFSAPYGLTTAERRHPE
                     FRTHGVGKCEWDGAIWPFASAQTLTAMANFMNNYPQRVLSDSVYFRQMELYVESQYHRG
                     RPYIGEYLDEVTGYWLKGDQERSRYYNHSTFNDLMITGLIGLRPRLDDTVEVNPLIPAD
                     KWDWFCLDNVLYHGRNLTILWDKYGDRYHRGKGLRIFVDGKQVGYADRLTRIICENVLK
                     "
     gene            12584..14851
                     /locus_tag="BcellWH2_04908"
     CDS             12584..14851
                     /locus_tag="BcellWH2_04908"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF05592.5"
                     /codon_start=1
                     /transl_table=11
                     /product="GH78|CBM67"
                     /protein_id="ALJ62117.1"
                     /translation="MMFLKRYIFFLLCLPCLAQAKNITVSHLTCEMQEGLVLVEAYPRL
                     GWTMESPENGTRQTAYEIEIREACTGRTVWNTGKVQSSQSQLIPTHGAKFLRFSFYNYI
                     WRVRVWDETDAPSEWSREAKFRLVPQGFSSAEWIGAITRKDARLPEGRKFHGGELKKPE
                     VKAAWEDVDTLAKKSICLRKTFRTDKKIAEATAYICGLGFYEFTLNGKKVGDSEFAPLW
                     SDYDKSVYYNMYDVTELLQEGENVAGVLLGNGFYNVQGGRYRKLQISFGAPTLLFSLLV
                     NYEDGTRDVVCSDDSWKYDLSPLTFNCIYGGEDYDARREQKGWNRAGFNDACWRPVVVQ
                     EAPKGTLRPQMAAPVKIMERYGVRKVTKLTPEQIASACKSTKRTIDLSAFVLDMGQNLS
                     GFPEITVRGKRGQKVTLVVAEALTEEGACNQRQTGRQHYYEYTLKGEGDETWRPRFSYY
                     GYRYIQVEGAVLKGEKNPRKLPVLKDIQSCFVYNSAKKVSAFECSNPIFNAAHRLIEKA
                     VRSNMQSVFTDCPHREKLGWLEQVHLNGPGLLYNYDLTAFAPQIMQNMADAQHRNGAMP
                     STAPEYVVFEGPGMDAFAESPEWGGALVIFPYMYYETYGDDSLIKKYYQNMRRYVDYLS
                     TRADNHILSFGLGDWYDYGDFRAGFSRNTPVPLVATAHYYMIVEYLIRAARIVGNADDV
                     RYYNSLANDIVVAFNERFLDYDAAQYGTGSQCSNALPLFLDMVLSRGHSGGCRYQFSKT
                     RL"
ORIGIN
        1 atgaaaaaag aagagatctt ttctagaaaa acacagagca ggtatctgag cgcagcaaag
       61 ataatttgtc tctctttctt gttttcgatt cctgtgacgc aggcttttgc ggaaagcatt
      121 agagagactg ctgcaatgaa tgttgtccaa caacagaagt cagtgaaagg aactgtggta
      181 gatacgaccg gagaacctgt gattggtgcg aatataaagg cacaaggaac tgatacagga
      241 acgattaccg atttggatgg aaatttcagt ctggtgattc cggcaagtgc taaactcgaa
      301 gtttcgttta taggatacgt cacgcaagtg gtgagtgtgc ctgcgaacgg aattgtaaac
      361 gtgactctgg ctgaagattc caaacttctg gacgaagtgg ttgtggtagg ttacggtact
      421 cagaaaaaag cacatcttac tggctctata tccacggtta accccaatga cctaaaggaa
      481 atgccctata gcaatatggg tgccatgctg gcaggtacgg tagctggttt gaatgtaagc
      541 ggcggtgatg gtcgccctgg tgtcggtgca acgatgacca ttcgtgatcc gttctctacc
      601 ggcgtttcgg gaagcacgac tgcgccgatt tatgtgattg atggtgtcat tcagtctgat
      661 aatccgcgta atggaatatc ggcttcggaa gcgtttaata accttgatcc gaacgaaata
      721 gaatctatat ctatcttgaa ggatgctgct gcggcagtgt atggagcacg tggcgcacaa
      781 ggtgccatca ttgttactac gaagaaaggc agcaaggacg gaaaacctcg catcagttac
      841 actggttcgg tgacgatgaa tgatgaaatt tcacgtccaa agatgttgga tgcatatcag
      901 tatggtcaat tctggaatgg atttaaaggt gctgacggca atgatgctat cggtaatcgt
      961 aaaaaagacc ttttccaatt ggacgagttg gaagctatga aaagcatgaa ctatgactgg
     1021 ctggacaaag cctggtcggc tgcctatagc acgaagcata atgtgaatat cagtggcggc
     1081 ggaaataact catcttattt cggaagcata tcttatcaga gccaggaggg taacctgagc
     1141 atgttggatt atgaccgttg gaattatcgt gtaggaatga gtacaacagt ggctaagcat
     1201 ctgaaagtga atttatctat ttcgggtaac tatggtgacc ggaaaacaac tttcaataag
     1261 attggcggag agaaggatga taatgattac ctggcattgc tgactacacc ccgctatgtg
     1321 ccatggtctg tagaaaatga taaaggcgaa gatatctggt tgttgagata tggacctaag
     1381 aataccaaca gtagtgttct cggaaactcg aactatttgc gttacaacta tttcgctgtt
     1441 gaagatttag gtaatcagaa acaaaccaaa actcaggata tgaccatcaa tggttcattg
     1501 gagtatgatt ttgattggtt ggagacattg aaaggtttga aactacgttt cagctatgca
     1561 aaaagtatcg gtaatacgga aggaagacaa ttgggatcta aatataacgg ttattatttt
     1621 accacccgtg gtggttcagg taatcacctt tatattgatg aaggtgcgcc aagtaataac
     1681 ctgactttgc cgtctaatat gaaaacacag tcggttgata atggaaaccg cgtactgcgt
     1741 gacttcgacc gtacagacaa ttatcaggtc aacttccagg caagttatgc gcgcgacttc
     1801 ggaaaacatt cggtaagtgc catgttcgct atggaaaagc gtgaaatgaa ctacgagttt
     1861 tcacgtattc tgaaagaagg tccgctgaat ggtgatcttg ctaatggtga aaccaataca
     1921 gctacaggtt cggtaagttc cagtagccag acggcgagaa gtgaaagtgg tgacttatct
     1981 tacattggtc gtgttaacta tgcctatgac ggtcgttacc tgtttgagtt cctgattcgt
     2041 tctgacgctt caaccaaatt ctcgccggat aactattggg gagtattccc ttccgtatct
     2101 gtgggctgga ttgtttcaga agaaaagtgg tataagctgg attggatgga ttatctgaag
     2161 gtacgtgcct cattcggtat tttgggacaa gataatacgg cagcttggct gtggcgtcag
     2221 cgatatacgt atcaggctaa ttatggtgca atatttggca cttcaccgag caacaattta
     2281 ggttgggctt taaagactga ggctgctccc aactatgatg cgcactggga taaagactac
     2341 aaattcaact taggaattga catgaaattc ctgaagaacc gtttatcagt aggtattgac
     2401 gcttatttgg acaagagaac cgatatgttg gtagtgcgta gtggtgtgcc tgtaactgta
     2461 ggtgccaaat cggctgccga gaatttcgat gcggtggata actatggtgt agaactttca
     2521 ttaggctggc gcgatcatgt gtctgacttc aactattccg ttcaactgaa tggacaatgg
     2581 cgtgacgccc gctatcgcaa aaaagactgg ccggccatat caacatacaa agatgtttat
     2641 cgcaatggac cggttgacat ggggcagtgg ggatatgact gtttgggaat gttccgtaac
     2701 caagctgaaa ttgacaagtt tgttgaggac tacaatataa cgcagtatat gggctataaa
     2761 ccggatcaga ttaaaccggg tatgctgata taccgtgatg ttcgtggcga acagaatccg
     2821 gacggttctt ataaagatgc agacggtatc gtagacgata aggatatggt tcgtttgagc
     2881 agaagaaaga gcaatcctta tggcatgtct ctgattctgg gtggtagctg gaaaggtatc
     2941 tctttgaatg ccaacatctc tagttcatgg ggtggatatt ctacgtatgc gggaggttcc
     3001 tatatcttca tgaacgagaa ttcactggat ggtgccaacc ttccgatata ttggaaagat
     3061 atgttcgttc ccgaagatgt agtggatgat ggaggcaatg tggtcgttaa acagaatttg
     3121 tctgccaaat accctaacat gaaatacagt atgaataatg aagcgtccaa tttctggcag
     3181 attagttcat tccgcatgta tcttcgtaac gtatccttag gttatacatt gcctaaggaa
     3241 tggctgagca aaataggaat ctcaagctgt aagatcaatg tgacgggaac caatctcttc
     3301 agtttcttca atccttatcc cgaaagttat acggatcctc tgaccggtta cggtacgttc
     3361 ccggcattgc gcagctggac tgtgggattg aatctttctt tttaaatgat ataattgata
     3421 aacaagatta gaatatgaaa atagataata tcatacataa aggtgtgggg atagttgcct
     3481 tcagcgcaat atttctgctg ggcagttgta gcgatgactt cttgagggag aagaaggatt
     3541 ataatggctt caatgacgaa atatacagta atttcagtat ggcgcaggcc agtgtagact
     3601 atattcacag gcaggttgaa cccaaagtag gtggtgtaag cgcattgaat ggtagcacag
     3661 gatctgccga tgaattttct aagtctacat tagagtatgc cggttctaca cagtttgtgg
     3721 gtttggctga aatactttcc agtaacgtga attgttattt caacggttcc aatgatccgg
     3781 ctaataataa cggtgtatgg ttaaatgtcc gtcgttgcaa tctatttctc gacaatattg
     3841 acaaaggaac attgtcggaa gaggaaagaa atctccttaa aggacaagtt tacttctggc
     3901 gtgcatggtt gtattatcgt ttggtgacta cttatggtgg tgttcctatt ataaagagcg
     3961 cgcaaaatcc gacaattgga gacggtacaa tagaagaatc gactctgaat gttgaacgta
     4021 gttctacgga tgattgcgtg acgtttgtct gcgaggatct ggataatgcg gcttctctgt
     4081 tgccatctgt ttgggctgat ccgtcggtaa attacggtcg tgtgactaag ggtgcggcta
     4141 tggctttgaa gggacgcttg ctgctcttct atgcaagtcc attgttcaac cgttccaacg
     4201 ataaggcacg ctgggatgcc gcctatactg caaacaaggc tgcttatgat gaacttacta
     4261 ccaatggtga cagagaattg gtaggtgcaa cgagtaaaag agcgcaggat tgggaaaaaa
     4321 tgtttgtgaa ccccttgtct aaagaggctg tactgataac attgtacaat aatatctctg
     4381 atgatcagtt caagttcaat aacagctggg aacaaagtgc ccgtcccaaa gacatcaaag
     4441 gtggtggtgg tatcgctgcc acggctgaaa tggtggattt attccccatg gctgatggta
     4501 agaaaccagg tgaaagctca ttgtcttatg acccgttgaa gttctacaag gatcgtgatc
     4561 cacgcttcta tcgcaccttt gcatttaacg gagtttgctg gccttataat accaataaga
     4621 catatacggt atggaattat caatggttta aggatgctgc cgcagccgtt gaaggcaaac
     4681 cgggtaattc agcgctttat gacggtgatg tcagttcaag tatctttgta cgcaaacgca
     4741 cggatccgaa tgcttacaat acttccaatc tcagtagcgg agtattttcg cagagtagta
     4801 gtccgtatat ggaaatacgt atggcggaag ttattcttaa cgtagcggaa gcagcttgcg
     4861 gaaaaggaga taatgctacg gcattgactt tcctgaaata tattcgcgaa cgtgtaggct
     4921 atacgggcga ttgcggcttt tcttctactt tagcgggtga tgccttgatg ggtgctattc
     4981 tttatgagcg tcagatagaa ctggcctatg agggaaagag attcgatgat atgcgtcgtt
     5041 ggcttttgtg ggacgacagt tttggtactt gcacacggtt gggtgttgag cctatcagcg
     5101 gaaaccaaac gcgcaggcat ggtattatcc tggctgtgaa acctgaactc tatacgaata
     5161 gcaaggccgg caaggattgt gatccgttca atccggaagc ttcagaatac ttgggaacat
     5221 cagaccgtac aaaaatcagt cttgatccgg atgcttcaga ctcagactgg gaaaatcaga
     5281 ttgctacctt ggacaatttt tacgaaaaca atctgaatcg tgtagtaaac gatcagcttg
     5341 atggtacaag tacgcctaca ttctatatta ctcacctgaa caaatactat ttcctaggta
     5401 tcaagcagaa tgtattgcaa aacagtatta agttgcaaca gaatattggc tggacggatt
     5461 attatggttc cgaaggaacg tttaatccta tcggtaacgg tagtttgctg ccgtaagttg
     5521 gcttttaatt tttttgtgag atagttaaaa ctgccgggtg atccttcatc cggcagtttt
     5581 tttagagtgg ttgccatcat tctatggatt atttttctac taaaatagtt tcatgtgatt
     5641 acaaaacatt tttatcttcg tctaataaat acaattaatt aatagatacg agaataatga
     5701 aaaagaaagc attcctgata gtttgtacag ctgcaatgct ggctccgacc attgcatggg
     5761 cacaataccc gcaattgacc gatgaagcca aggagactta taagaaaatg ataactgaag
     5821 aacgccggcg ttcggatgaa gcttgggcga aagcattgcc tatcgttgag aaagaagcca
     5881 gagaagggcg tccgtatatc gagtgggctt cccgtccgga tgatcttcct caagccggta
     5941 ttcccgcttt tcccggagct gagggtgggg gaatgttcac tcccggtggc cgtggcggca
     6001 aggtaattac agtaactaat ttgaatgatc gcggcccggg ctctttccgt gaagcttgcg
     6061 aaaccggtgg tgcacgtatc attgtattca atgtggctgg tatcattcga ttggaatctc
     6121 ccattattgt ccgtgctcca tacgtaacga tagccggaca aacagcccca ggtgacggtg
     6181 tatgtattgc cggagaatct ttctgggttg acactcacga tgtagtggta cgtcatatgc
     6241 gtttccgtcg tggtgaaacg aaggttcatc accgtgacga ttcatttggg ggtaatccga
     6301 ttggtaacat tatgatcgat cactgttcct gtacttgggg gctggatgag aatatttctt
     6361 tctatcgtca catgtacagt cctggtgaag gatataaaga tgagaaactt ccgactgtca
     6421 atgtaaccat tcaaaataca atttccgcta aggcactgga tacatacaat catgctttcg
     6481 gtagtacatt gggtggtgag aactgtgctt ttatgcgcaa tctttgggcc agtaatgctg
     6541 ggcgtaaccc gtctattggc tggtatggga ttttcaattt cgtgaataat gtagtctaca
     6601 attgggtaca tcgttcagct gatggtggcg attatcgtgc tatgttcaat atgataaata
     6661 attactataa accgggtcct ttgactccga gagattctcc ggtcggtcat cgcattctga
     6721 agccggaagc cggacgtagc aagctggatt ataaagtata tggccgtgtc tttgcagatg
     6781 gcaatgtgat ggaaggatat cctgaaatca caaaggataa ctgggctggt ggtattcaga
     6841 ttgagactca aaaggataca gaggggtata ccgagcagat gcgtacgtat caacctttcg
     6901 taatgcctta tattaatatt atgtctgcaa atgatgctta tgattatgtt ttgaaatatg
     6961 taggtgctaa tattccttgc cgtgacattg ttgatgagcg ggttattgag gaagtgaaaa
     7021 ccggtcaagc ttattatgaa aagaaacttc cgaaagatgc ctatggagat aaatggggat
     7081 tagctccaaa atctcaggat gaggaaggtt attttaaata ccgtcgtttg ccgaaagatt
     7141 cttataaaca gggtattata actgatattc gccaaatggg tggctatccg gaatataagg
     7201 gaactcctta tgtggatacg gatggtgacg gtatgccgga tgaatgggaa attgcgaatg
     7261 gtctgaatcc aaacgatccg agtgatgcca ataaagattg cactggtgat gggtatacta
     7321 atattgagaa atatatcaat ggtatcagta cgaagaataa ggtagactgg actgatatga
     7381 agaataacta cgatacattg gcagaaaaag gtaaattaat gtaatgtcaa tgaaaaagat
     7441 aatattaatt tctttattac tggttttcgg ttggttatca gccggagcgg tagacttgaa
     7501 taaggataat cgtgatcctc aatatgtgga atctattgtt aaacgatctc agaagatcgt
     7561 agataaactt gggcttacag atgtaaaggt ggctgaagat gttcgtaatg tgattgccaa
     7621 tcggtacttc gaactgaatg atatttatga agttcgtgat gccaaagtga agaaaataaa
     7681 ggagtcggga ttgagtggtg ctgcaaagga tgatgccttg aaagcggctg agtatgaaaa
     7741 ggatgcggca ttataccgtt ctcactttgc atatcccgcg aatttatctc tttttctgga
     7801 tgagaagcaa atagaagtgg tgaaggatgg gatgacttat ggcgttgtga aagtgacgta
     7861 tgatgctaca attgacatga tcccttcttt gaaggaagaa gaaaaagcac aaatctatgc
     7921 ctggctcata gaagcccgtg agtttgcctt ggatgctgag aattcggata agaaacatgc
     7981 agcctttggt aaatataagg ggcgtatcaa taattatctg gctaaaagag gatatgattt
     8041 aacaaaagaa cgtgaagagt ggtacaagcg tgtgaaagca cgtggaggct ctctctgata
     8101 attaggatag ataaaaactg gttagttatg tgatgtgaag ggtggctgag aagtcaccct
     8161 tttctgtgtt ctgatttttg gaatatggcg aatcttccat tatctttgag tacaaattcg
     8221 tcttattgcc gtctcctctg tatacagaat acgatataaa aacaaaagta ttatttagaa
     8281 atgagaaaat taagaaatac attagctgca ataagcattt tgttcttagc ttcttgtgga
     8341 ggaaacaaag actactatat gttcacttca ttccatgagc cggctaatga aggtttaaga
     8401 tatctatata gtgaagacgg catgcattgg gatagtgttc ccggtgtttg gctgaaaccg
     8461 gaattgggac aacatcagtt gatgcgcgat ccttcgatgg tacgtactcc ggacggtact
     8521 tatcatttgg tttggaccac cagttggaaa ggtgatttgg gatttggcta tgcatattcc
     8581 aaagacttga ttcactggtc ggagcaacaa atgattccgg taatggccca tgaaccgacg
     8641 accgtcaacg tgtgggcacc ggagattttt tatgatgatg aggctgaaca attcatggtg
     8701 gtctgggcat cttgtgttcc ggggcgtttt gaaaagggta tagaagaaga aaagaataac
     8761 catcgcttat attacatcac tacaaaagac tttaagacga tatccgaaac caaacttttg
     8821 tatgatccgg gcttcagttc aattgatgct accatcataa aacgtgcaaa gaatgattat
     8881 gtaatggtgc ttaaagataa tacacgtccc gaacgtaatc tgaaagttgc ttttgccgat
     8941 tcattgacag gaccttattc gcctgcatcg caacctttca cggaatcgtt tgtagaaggc
     9001 ccctctgtag agaagatagg agatgactat cttatctatt tcgatgtcta caggaagaaa
     9061 atatatggcg ctgtgcgtac cagggatttt cgtaatttta cggatgaaac cggaaatgta
     9121 agtgtaccca caggccataa acatgggact attttcaaag ccccggaatc gctcgttaag
     9181 gagttgttga aagaaagcaa gaagaaataa tatataaaac aggaacagat aatgaacagc
     9241 cctatcaaaa tactttttgt tctggcaact ggatggctga cactaacgtc ggcttcagca
     9301 caagacagga tacattacac tggaaccgaa ctttctaatc ccacctatca tgatggacaa
     9361 ttgtcgccgg tagtgggagt gcataatatt caattggtac gtgccaatcg tgaacatccg
     9421 gatgcgtcga atggtggagg atggacttat aatcaccaac cgatgttggc ctattggaat
     9481 gggcaattct attatcaata tctggcagat ccgtcggatg agcatattcc gccttcccag
     9541 acttttctga tgacttctaa agacggatat aactggacaa atccggaaat cgtgtttcct
     9601 ccttataaag ttcccgacgg atatacgaag acttcccgtc cgggtatgca ggcaaaagac
     9661 ctgattgcca tcatgcatca gcgtgtgggc ttttatgtat ccaagtccgg cagactgatt
     9721 acaatgggga attatggagt tgcgttggat aaaaaagatg atccgaatga tggaaacggt
     9781 attggtcggg tagttcgtga aattaagaaa gacggttcat tcggtcccat ctactttata
     9841 tattataatc atggatttaa tgaaaaaaat accgattacc cttatttcaa gaaaaataag
     9901 gatcgtgagt ttgtaaaggc ttgtcaggaa attctggata atccattgta tagaatgcaa
     9961 tgggtggaag aggcggatcg ggaagacccg attattcctt tgaagaaggg atataaagcg
    10021 ttcaattgct atactttacc cgacgggcgt attgtcagcc tttggaaaca tgcactgact
    10081 tcaatcactg aagacggtgg ctatacttgg gcggaaccgg tgcttcgtgc caaaggattc
    10141 gttaatagca atgcaaagat ttggggacaa cgcctgactg atggtatgta tgctaccgtg
    10201 tataatcctt cggagtttcg ctggccgctg gctatatcgt tgagtaagga tgggctggaa
    10261 tatacgacct tgaacctcgt gcatggtgaa attccgccga tgcgttatgg aggaaactat
    10321 aagtcgtatg gtccgcaata tccccgcggt attcaagaag gaaatggaat tcctgcggat
    10381 ggtgatttat gggttgctta cagtgtgaac aaagaagata tgtgggtatc acgtattcct
    10441 gttccggtac agatacaagc ctctgcacat gcagacgatg atttctcaaa agccggatca
    10501 atagctgagt tgaccgactg gaatatttac tctccccttt gggctccagt cactttagac
    10561 ggaaagtggc tgcgtttgca agataaagat ccttttgatt atgccaaggt agaacgaaaa
    10621 ataccggctt ctaaagaact gaaaatctca tttgatctac aggccggaca aaacgataaa
    10681 ggtactcttc agattgactt cctggatgag aacagcattg cttgttcccg gcttgagctg
    10741 actcctgatg ggatttttcg tgctaaaggc ggttcccgct ttgggaacct gatgaaatat
    10801 gaaccgggaa aaaactatca tgtagaggct atcctttcag tgaccgatcg taatattcag
    10861 gtatttgtgg atggtaagag agtaggattg cgcatgttct atgcaccggt acctgctatt
    10921 gaacgtattg cgttccgtac aggagttcca cgaatatttc ccactgtaga tacaccggct
    10981 gatcagacct atgatctgcc gaatgccggt gaccaggagc cactagctga ataccgtatc
    11041 gccaatgtga aaacctcttc tgtggataaa gatgcgactg ctgctgtttt ggagtatgcg
    11101 gatttcagcc attatgcaga ttatttcaat ggtatggaag atgagaatat agcccaggcc
    11161 attccgaatg caaaggcttc ggaatggatg gaagagaata taccgttgtt tgaatgtccg
    11221 caacgtaatt ttgaagagat gtactattac cgctggtggt cgttgcggaa gcatatcaaa
    11281 gaaacacctg tgggatatgg catgacggaa tttctggttc agcgttccta ttctgataaa
    11341 tataatttga tagcctgcgc gatcgggcat catatttatg aaagccgttg gttgcgcgat
    11401 ccgaagtatc tgaatcagat tattcatacg tggtatcggg ggaatgatgg cgggccgatg
    11461 aataagatga ataagtttag ttcgtggaat gcggatgctg tgctggcacg ttatatggtg
    11521 gatgctgata aggatttcat gctggatatg aaggaaaatc tggaagccga gtatcaacgc
    11581 tgggagtgca cgaaccgttt gcaaaacgga ttatattggc aaggagatgt acaggatggc
    11641 atggaagaat caatcagtgg cggacgtaag aaaaagtatg cccgccccac cattaatagc
    11701 tatatgtatg gtaatgcaaa agctctttca ctgatgggaa tcctttcgga tgatgaagga
    11761 atggctatga gatatggtat gcgggcggat acattgaaaa ggctggtaca agataagttg
    11821 tggaattcac gtcaccagtt ttttgagaca atgcgtgcgg actcttctgc gaatgtacgc
    11881 gaggctatcg gatatatacc ttggtacttt aatttgccgg acacagtgaa gcaatatgaa
    11941 gttgcctgga aagagattat ggatgagaac ggtttttctg ctccttacgg attaactact
    12001 gccgagcgcc gtcatccgga atttcgtacc cacggagttg gtaaatgtga atgggacgga
    12061 gcaatctggc cgtttgcttc tgcccagaca ttgacagcaa tggctaactt tatgaataat
    12121 tatccacaga gagtattatc cgatagtgtg tatttccgtc aaatggaatt gtatgtcgag
    12181 tcgcaatatc atcgcggacg tccttatatt ggtgaatatc tggatgaggt gacaggttat
    12241 tggctgaaag gtgaccagga acggagtcgt tactataacc attctacctt taatgatttg
    12301 atgattaccg gtctgattgg attacgcccg cgcctggatg atacggtaga agtaaatccg
    12361 ttgataccgg cagataagtg ggattggttc tgtctggata atgttttata tcatggtcgt
    12421 aacctgacaa ttctttggga taaatatggt gatcgttacc atcgcggaaa aggattgcgt
    12481 atttttgtag atggaaaaca agttggatat gcagatagat tgacgagaat catttgtgag
    12541 aacgtcttga aataatggtt actactgaaa tagaaaaaaa cgaatgatgt ttttaaaaag
    12601 atatattttc tttcttcttt gcttgccgtg tctggcacag gcaaagaata taacggtcag
    12661 ccatctcact tgcgaaatgc aggaagggct ggtgctcgtt gaagcctatc ctcggctggg
    12721 gtggaccatg gagtcgccgg agaatgggac gaggcagact gcttatgaga ttgagattcg
    12781 ggaagcctgc accggacgta cggtttggaa tacgggaaag gtccaatctt cgcaaagcca
    12841 gttgataccg actcatggag cgaagtttct ccgatttagt ttctataact acatctggcg
    12901 tgtacgggtt tgggatgaaa cggacgcgcc ttccgaatgg agtcgagaag caaagtttcg
    12961 tttagttccc caaggttttt cttcggctga atggattggg gccatcaccc gtaaagacgc
    13021 acgcttgccc gaaggacgga aattccacgg aggcgagttg aagaagccgg aggtaaaggc
    13081 ggcatgggaa gacgtggata cattggcaaa gaaaagcatt tgcttgcgta agacgttccg
    13141 cacggacaaa aagattgcgg aggctaccgc atacatctgt ggccttggat tctatgagtt
    13201 caccttgaat gggaagaaag tcggtgacag tgaatttgct cccctctgga gtgattatga
    13261 caagagcgtc tattataata tgtatgatgt aacggaactg ttgcaggagg gcgagaatgt
    13321 ggcgggagtt ttattgggaa acgggttcta taatgtgcag ggcggacgtt accgcaagtt
    13381 gcagatcagc ttcggggcac cgactctttt attctcactg cttgtcaatt atgaagatgg
    13441 aacacgggat gtggtttgct ctgacgacag ttggaaatat gacttaagcc ccctcacctt
    13501 taattgtatt tatggaggcg aagattatga tgcgcgtcgc gaacaaaaag ggtggaaccg
    13561 ggcaggtttt aatgatgcgt gttggcgccc ggtagtggtt caggaagctc cgaagggaac
    13621 gttgcgtccg caaatggcgg ctccggtgaa aattatggaa cgttatggtg tccggaaagt
    13681 gacgaaactg accccggaac agattgcctc tgcctgtaaa tcgaccaaga gaaccatcga
    13741 cctttccgct ttcgtactgg atatggggca gaacctttcc ggttttccgg aaattaccgt
    13801 gcgtggtaaa cgaggtcaga aagttacttt ggtggtggct gaggctctga cggaggaagg
    13861 agcctgtaac caacggcaaa cgggacgtca gcattactac gaatatacct tgaagggtga
    13921 gggggacgag acctggcgtc cccgtttctc atactatggt tatcgctaca ttcaggtaga
    13981 gggtgccgta ctgaaggggg agaagaatcc ccggaaattg cctgttctga aagatattca
    14041 atcctgcttt gtttataact cggcaaaaaa ggtgtctgct ttcgagtgtt ccaatccgat
    14101 attcaacgct gcccatcgtc tgatagagaa ggcggttcgc agcaatatgc agtctgtgtt
    14161 taccgattgt ccccatcggg aaaagctggg atggctggaa caggtgcacc tcaacgggcc
    14221 gggactttta tacaattatg acctgacagc tttcgctccg cagattatgc agaatatggc
    14281 ggatgcccaa catcgcaacg gagccatgcc aagcaccgca ccggagtatg tcgtgttcga
    14341 aggaccgggc atggatgcct ttgccgaatc tcccgagtgg ggaggtgctt tggtcatttt
    14401 cccgtatatg tattacgaaa cctatgggga cgattcgctg attaagaagt attaccagaa
    14461 tatgcgccga tatgtggact atctctctac ccgcgcagat aatcatatcc tttctttcgg
    14521 tttgggcgac tggtatgatt acggtgactt ccgtgcagga ttctcccgca atacgcctgt
    14581 cccgctggtg gctacggcac actattacat gattgtcgaa tatctgataa gggctgctcg
    14641 cattgtgggt aatgctgatg atgtcaggta ttacaattcg ttggcgaatg atatcgtggt
    14701 agcattcaac gaacgctttc tggattacga tgcggcgcag tatggtacgg gaagccagtg
    14761 cagcaatgct ttgccgcttt ttctggatat ggttctgagt agaggccatt ctggtggttg
    14821 ccgttaccaa ttctccaaaa cacgacttta a
//
