LOCUS       NZ_CP012938            12369 bp    DNA     linear   CON 06-APR-2020
DEFINITION  Bacteroides ovatus strain ATCC 8483 chromosome, complete genome.
ACCESSION   NZ_CP012938
VERSION     NZ_CP012938.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN03852683
            Assembly: GCF_001314995.1
KEYWORDS    RefSeq.
SOURCE      Bacteroides ovatus
  ORGANISM  Bacteroides ovatus
            Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
            Bacteroides.
REFERENCE   1  (bases 1 to 12369)
  AUTHORS   Wu,M., McNulty,N.P., Rodionov,D.A., Khoroshkin,M.S., Griffin,N.W.,
            Cheng,J., Latreille,P., Kerstetter,R.A., Terrapon,N., Henrissat,B.,
            Osterman,A.L. and Gordon,J.I.
  TITLE     Genetic determinants of in vivo fitness and diet responsiveness in
            multiple human gut Bacteroides
  JOURNAL   Science 350 (6256), aac5992 (2015)
   PUBMED   26430127
REFERENCE   2  (bases 1 to 12369)
  AUTHORS   Wu,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-OCT-2015) Center for Genome Sciences and Systems
            Biology, Washington University School of Medicine, 4444 Forest Park
            Ave., Saint Louis, MO 63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP 2.0 and Celera v. AUG-2014
            Genome Coverage                   :: 350X
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 04/05/2020 01:05:09
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 4,918
            CDSs (total)                      :: 4,825
            Genes (coding)                    :: 4,751
            CDSs (with protein)               :: 4,751
            Genes (RNA)                       :: 93
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 2
            Pseudo Genes (total)              :: 74
            CDSs (without protein)            :: 74
            Pseudo Genes (ambiguous residues) :: 0 of 74
            Pseudo Genes (frameshifted)       :: 25 of 74
            Pseudo Genes (incomplete)         :: 42 of 74
            Pseudo Genes (internal stop)      :: 16 of 74
            Pseudo Genes (multiple problems)  :: 8 of 74
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            CP012938.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12369
                     /organism="Bacteroides ovatus"
                     /mol_type="genomic DNA"
                     /strain="ATCC 8483"
                     /isolation_source="feces"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:8483"
                     /type_material="type strain of Bacteroides ovatus"
                     /db_xref="taxon:28116"
                     /country="USA:Woods Hole"
                     /collection_date="11-Oct-2009"
     gene            1..1644
                     /locus_tag="Bovatus_RS16640"
                     /old_locus_tag="Bovatus_03419"
                     /db_xref="GeneID:29454937"
     CDS             1..1644
                     /locus_tag="Bovatus_RS16640"
                     /old_locus_tag="Bovatus_03419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004313825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004298106.1"
                     /db_xref="GeneID:29454937"
                     /translation="MKKKYLIFLLLLSFPLYTWADKTLDSLLNVLDLTIQEHETYVAQR
                     ESRIRHLKELTHEIEASSAEHYNLNSQIYKEYKAFICDSAIHYLNENIRIAERLHDTDR
                     KIESQLQLSLLLSSTGMYTESIDVLESVDRQKVVSRLIADYYTCFDHVYGELSVYTQDK
                     TLSGRYWSISQAYRDSLYAILPPESEEYLMMREASLRDQHQYEEALKVNDLRLAEIEVN
                     TPQYALVTYHRSLIYKYSNDSLGEKRNLCLSAISDIRSAIKDHASLWMLAQLLYEDGDM
                     ERAYQYMRFSWNATKFYNARLRSWQSADVLSLIDKTYQAMIEKQNDRLQQNLLLITALL
                     VLLIVALGYIYRQMKKLADARNHLQVANGQLNGLNEELRQMNSCLSSTNIELSESNQIK
                     EEYIARFIKLCSTYINRLDAYRRMVNKKVSAGQIAELLKITRSQDALDEELEELYANFD
                     TAFLHLFPNFVGKFNDLLQDNEHILPKKDELLNTELRIFALIRLGIEDSSQIAEFLRYS
                     VNTIYNYRAKVRNKARGSRDDFEILVRKIR"
     gene            1854..4859
                     /locus_tag="Bovatus_RS16645"
                     /old_locus_tag="Bovatus_03420"
                     /db_xref="GeneID:29454951"
     CDS             1854..4859
                     /locus_tag="Bovatus_RS16645"
                     /old_locus_tag="Bovatus_03420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004309888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q45780|1.B.14.6.1"
                     /protein_id="WP_004298107.1"
                     /db_xref="GeneID:29454951"
                     /translation="MKKNKRKILSGSRKIFFAILAMFLSLSASAQQFTASGQVLDAQKE
                     PLIGVSVQEKGTSNGAITDLDGNFTLNVKQNAILIFSYVGYKSQEIKAARQMKITLQED
                     NEVLDEVVVIGYGSVKRKDVTTAISSVSTKDLDMRPIVSAGQAIQGKAAGVSVIQPNGT
                     PGGEMSIRVRGTTSMNGSNDPLYVVDGVPVDNIKFLSPNDIESMQILKDASSASIYGSR
                     AANGVILITTKAGASGNAKVSLTAQFGLNKVADKVESLNSAQYKELQDEIGLVSLPDGL
                     PDRTDWFDETYTTGKTQNYQVAVSNGNEKMKYYLSAGYLKEQGVLDISYYKRYNFRVNL
                     ENQVRKWLTISANISYSDYTSNGGGAMGTGANRGGVILAVINTPTYAPVWDALNPNQYY
                     NNFYGVGNITNPLENMARAKNNKDKENRLLASGNILLTPFPELKFKSTLTLDRRNAVNT
                     TFLDPISTAWGRNQYGEGSDNRNMNTVLTFDNVLTYNKNFKKHGLEVMAGSSWTDSDYS
                     NSWINGSHYRSDLIQTLNAANKISWDNTGTGASQWGIMSFFGRVAYNFDSKYLLTANLR
                     ADGSSKLHPDHRWGVFPSFSAAWRISSEKFMENLTWIDDLKLRGGWGQTGNQSGIGDYA
                     YLQRYNIGRIEWFKKGGEGDSTDYANAVPTISQANLRTSDLTWETTTQTNIGLDLTILN
                     GRLTFNADYYYKKTKNMLMNVSLPAGAAAATSIARNEGEMVNKGFELSISSKNLRGGAF
                     TWDTDFNISFNRNKLTKLELQKVYYDAKTADVVNDYVVRNEPGRALGGFYGYISDGVDP
                     ETGELMYRDLNNDGKISSSDRTYIGDPNPDFTYGMTNTFSWKGFNLSIFIQGSYGNDIY
                     NASRIETEGMYDGKNQSTRVLNRWKIPGQITDMPKANFKLLNSTYFVEDGSYLRLKDVS
                     LSYNFKGKLLKKWGITRLQPYFTATNLLTWTSYSGMDPEVNQWGNSGTVQGIDWGTYPH
                     CRSYVFGINVEF"
     gene            4859..6394
                     /locus_tag="Bovatus_RS16650"
                     /old_locus_tag="Bovatus_03421"
                     /db_xref="GeneID:29454954"
     CDS             4859..6394
                     /locus_tag="Bovatus_RS16650"
                     /old_locus_tag="Bovatus_03421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007749848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RagB/SusD family nutrient uptake outer membrane
                     protein"
                     /protein_id="WP_004298108.1"
                     /db_xref="GeneID:29454954"
                     /translation="MKGKIMKLRTIFYGLTSGLLLGLSSCSLNYEPLDTYSDVTEGVTS
                     DGTKIVFKDKAAVESHLTTLYNQMRDRQEHWYVDLLLIAESHADNAYAGTTGAEVVPFE
                     NNSIEGSNSVLERDWNRYMEDVARANILICNIDAVTDNSLTTAERAQYKAEAKIFRAMI
                     MFDMVRLWGDFPVITTVAEDITSDNIEDVYPQYFPEQNTELEAYQQIERDLLDAVQYAP
                     DNTPGNKTLFTKSVARTLLAKIYAEKPLRDYTKVIQYCDEVKADGFDLVDDFSDLFGMN
                     AAGTDAKMRNTKESILEAQFTPGAGNWCTWMFGRDLVNWNNNFTWAKWVTPSRDLISTF
                     KQEGDEVRFKESVVYYDCGWSNYYPSDNYPFMYKCRSANSSIIKYRYADVLLLKAEALI
                     MQDTPDLEGAADIIDEVRDRAKLGALSSSTRSNKDALLNALLKERRLELAFEGQRWFDL
                     VRLDKVEEVMNAVHAKDSGRKAQVYTYDKNSYRLPIPQSVIDANDKIHQNPGY"
     gene            6426..7916
                     /locus_tag="Bovatus_RS16655"
                     /old_locus_tag="Bovatus_03422"
                     /db_xref="GeneID:29454958"
     CDS             6426..7916
                     /locus_tag="Bovatus_RS16655"
                     /old_locus_tag="Bovatus_03422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008998239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH30_3|GH30"
                     /protein_id="WP_044919071.1"
                     /db_xref="GeneID:29454958"
                     /translation="MIDMRNIALTFLGCFTILAACSNSDDAEKPVAPIPTGDVTIYSTT
                     NSLTRDLTRDAVNFSLKDNLAPTSITLNPTEQYQTMDGFGVAITGATCFNLLQMKPEDR
                     HAFLTETFSDDKGFGFSYIRISIGCSDFSLSEYTCCDKKGIENFALQSEEKEYILPILK
                     EILDINPSIKIIAAPWTCPTWMKVKSLTDLTPFESWTNGQLNPAYYQDYATYFVKWVQA
                     FNAEGIDIYAVTPQNEPLNRGNSASLYMSWEEQRDFVKTALGPKFKTAGLATKIYAYDH
                     NYDYSDIETEKNYPGKMYEDPAASQYLAGAAYHNYGGNREELLNMHKAYPEKELLFTET
                     SIGTWNSGRDLSKRLLEDMKEVALGTINNWCKGVIVWNLMLDNDRAPNREGGCQTCYGA
                     VDISNSDYKTIIRNSHYYIIAHLSSVVKPGALRIGATGYADSNIMYSAFENPDGTYAFV
                     LMNNNEKTKRITFSDGKRHFAYDVPGKSVTSYRWAKSE"
     gene            7939..9936
                     /locus_tag="Bovatus_RS16660"
                     /old_locus_tag="Bovatus_03423"
                     /db_xref="GeneID:29454962"
     CDS             7939..9936
                     /locus_tag="Bovatus_RS16660"
                     /old_locus_tag="Bovatus_03423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015532068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5125 domain-containing protein"
                     /protein_id="WP_004322519.1"
                     /db_xref="GeneID:29454962"
                     /translation="MKKNIYIILAMAGILSMNSCSDDEFLPGSPSMEIKAENADALFGD
                     SLPFTIKASDVDVPLSTLKAQLFYGEEQVSETVIRTKTSGNDYTGKIFIPYYANIPNGK
                     ATLKYILQNIHFTTTEMTKELALARPDFPYLTLVDEEGKEYRMERQSMYQYSVTGDFSQ
                     KMKAYIKTPKVGENGNELTFGWDNGTIETGSTNSISFSNTEPGSYAIKFNTLTYEAEPF
                     AKLKVNGEDMELVENDIYAIKLALKKNDILTFEGVPDYDNWWIDQDYFEKQEDGTLKFL
                     PIDGSYQITANGKLKYFSVIALKNGEAAKLQEDGTGAIWAIGTGIGKPSVALSEVGWTP
                     ENGLCMPQLTAKKYQLTFIAGVTMKVDDINFKFFYINKWDNGEFKGDAISTTSELVKIS
                     SDGNLGLQEGQKFERGGIYRFTVDVTKGNTKAVLTVEKVGKVDLPAPDIFFGNSKMEVT
                     DTDIYKSDQVFTRGQMITVTGIDNLNEWWIDPDFFEKQSDGTLKFLPINGDYRVTANGI
                     LKYFSVIALKDGKPAKLQDDGTGAIWAIGKGIGKPSVTSSEVGWETGKALCLAQVAPKK
                     YQLTLKAGETLKTSGDWEAISFKFFYQNDWGGEFSNYASNTLVEQLKLTGSGNLEMQDN
                     KAFEEGGVYRFTIDVTNGNANAILKVEKIN"
     gene            10123..12369
                     /locus_tag="Bovatus_RS16665"
                     /old_locus_tag="Bovatus_03424"
                     /db_xref="GeneID:29454966"
     CDS             10123..12369
                     /locus_tag="Bovatus_RS16665"
                     /old_locus_tag="Bovatus_03424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007479437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH3"
                     /protein_id="WP_004322518.1"
                     /db_xref="GeneID:29454966"
                     /translation="MKFKAMLLGLSVITALPAFAQKPVYLDTGKPIEERVKDALNRMTL
                     EEKVKMIHAQSKFSSAGVPRLGIPEVWATDGPHGIRPEVLWDEWDQAGWTNDSCIAYPA
                     LTCLSATWNPEMSHLYGKSIGEEARYRKKDILLGPGVNIYRTPLNGRNFEYMGEDPYLS
                     ATMVVPYIKGVQENGVAACVKHYALNNQEFNRHTTNVQLSDRALYEIYLPAFKAAVQEG
                     GTWSIMGSYNLYQGEHACHNKRLLRDILRDEWGFDGVVVSDWGGVHNTEQAIHNGMDLE
                     FGSWTNGLSAGTRNAYDNYYLAFPYLKLIKEGKVGTKELDEKVSNVLRLIFRTSMDPHK
                     PFGSLGSPEHGQAGREIAEEGIVLLQNNGNVLPIDLNKAKKIAVVGENAIKMMTVGGGS
                     SSLKVKYEISPLDGLKSRVGSKAEVVYARGYVGDPTGEYNGVKTGQDLKDNRSEDELLA
                     EALQVAKDADYVIFFGGLNKSNHQDCEDSDRASLGLPYAQDRVISELAKVNKNLIVVNI
                     SGNAVAMPWVNEVPAIVQGWFLGSEAGTALASVLVGDANPSGKLPFTFPAKLEDVGAHK
                     LGEYPGNKEELAQSKHRGDTINEIYREDIFVGYRWADKEKIKPLFPFGHGLSYTTFAYG
                     KPSADKKTMTADDTISFTVNVKNTGTREGQEVVQLYISDKKSSLPRPVKELKGFQKVKL
                     APGEEKAVTLTIDKKALSFFDDAKHEWVAEPGKFEAIIGSSSRDIKGIVPFELK"
ORIGIN
        1 atgaaaaaaa agtacctgat atttcttttg cttctctctt ttccactata tacctgggct
       61 gataagactc tggactcact gttgaatgtg cttgatttga caattcagga acatgagact
      121 tatgtagctc aacgtgaatc acgtatcaga caccttaaag agttgacaca cgagatagaa
      181 gcaagttctg cggagcatta caatctgaac agtcagatat acaaagaata taaagccttt
      241 atctgcgact ctgcaatcca ctatttgaat gaaaatatcc ggattgcaga gcgcttgcat
      301 gatacagacc ggaagataga aagtcagttg cagctttcat tattattatc ttcaacggga
      361 atgtacacgg agtctattga tgttttagaa tcagtagacc gacagaaagt tgtctcccgt
      421 ttaattgctg attattatac ttgctttgac catgtgtatg gtgaattgag cgtttatacc
      481 caggataaaa ccctttcggg acgttactgg agtatctcgc aggcatatag agattcttta
      541 tatgctatat tgcccccaga atcggaagag tacctgatga tgcgtgaagc atcacttcgc
      601 gatcaacacc agtatgagga agccttaaaa gtgaatgatc tccggctggc agaaatagaa
      661 gtaaatactc cacagtatgc attggtcact taccatcgct ctttgattta caaatacagt
      721 aatgatagtc tgggagagaa acgaaatcta tgtctttctg ctatatcgga tatccgttct
      781 gctattaaag atcatgcttc gttgtggatg cttgcccaac tactttatga agatggtgat
      841 atggaacgtg cgtaccaata tatgcgcttt tcctggaatg cgacaaagtt ctataatgcc
      901 cgtttgcgta gctggcagag tgctgacgtg ctttcattga ttgataaaac ctatcaggca
      961 atgattgaaa agcagaacga ccgtcttcaa cagaacctgc tgcttatcac tgcactgttg
     1021 gtgttgttga ttgtagcctt aggatatatc taccgtcaga tgaaaaagct ggcggatgca
     1081 agaaatcatc ttcaggtagc caatggacag ttaaacggat tgaatgagga gttgaggcaa
     1141 atgaatagtt gcctgtcttc caccaatatt gaactttcgg agtccaatca gatcaaggaa
     1201 gagtatattg cccgtttcat caagctgtgt tctacttata tcaaccgttt ggacgcttac
     1261 cggaggatgg tgaataagaa agtatctgcc ggacagattg cggaattatt aaagataacg
     1321 cgttcgcagg atgctcttga tgaagaactg gaagaattat atgctaactt tgatacagct
     1381 tttttgcatc tcttccctaa ttttgtgggg aaattcaatg atttattgca ggacaatgaa
     1441 catatcctgc cgaaaaaaga tgagttattg aacactgaac tacgaatctt cgctttaata
     1501 cgtctgggta ttgaagacag ttcgcaaatt gcggaatttc ttcgttattc agtgaataca
     1561 atctataatt accgggcgaa agtaaggaat aaggcccgtg gatcgagaga cgattttgag
     1621 attttagtac gaaaaattcg ctgattaaga ctgtaaacta accacttttt tggatatgtt
     1681 atatgtgtgt aaatggttga taatcatttt gatgatgttt tgtgtcatcc acttattgac
     1741 ccctccctgt tagctcactt taatttcttt atacttttga tctgtgcttc gaaggtaatg
     1801 agaacagcta ttacggacga gcatctatta ttaactttaa aattttagta cgcatgaaaa
     1861 agaacaagcg aaaaatcctt tcggggagtc gcaagatttt ctttgctatc ttggcaatgt
     1921 ttttatcttt gagtgcatct gcacagcaat ttaccgcgtc cggtcaggtc ctggatgctc
     1981 aaaaagaacc actaattggt gttagtgtac aagaaaaagg tacatctaac ggggcaatta
     2041 ccgatttgga tggtaacttc acattaaacg ttaaacaaaa tgccattttg atattctctt
     2101 acgtgggcta caaatcacag gagataaagg cagcccgcca gatgaagatc acacttcaag
     2161 aagataatga agtgctcgat gaagtagtgg tgatcggtta tggttcggtg aagcggaaag
     2221 atgtgactac cgctatctct tccgtatcta ccaaagattt ggatatgcga cctattgtgt
     2281 cggcaggaca ggccattcaa ggtaaggcag ccggtgtttc ggtgattcag cctaacggta
     2341 cgccgggagg tgaaatgtct atccgcgtac gtggtactac ctctatgaat ggtagtaatg
     2401 atccgctgta tgtggtggac ggagtgcctg tagacaatat caaattcctt tctccgaacg
     2461 atattgaaag tatgcagatt ttgaaagatg cttcttcagc atctatttac ggttcgcgtg
     2521 ctgccaacgg agtcattctt attactacga aagccggtgc ttccggaaat gcaaaagttt
     2581 ctctgacagc ccaattcgga ttgaacaaag tggctgataa agtggagtcc ttgaattcgg
     2641 cacaatataa agaactgcag gatgaaatcg gactggtatc tttgccggat ggattgcctg
     2701 accgcaccga ctggtttgac gaaacgtata cgaccggaaa gactcagaat tatcaggtag
     2761 ctgtatccaa tggtaacgag aagatgaaat actatctttc tgcaggctat ctgaaagaac
     2821 agggagtgtt ggacatctct tattacaagc gttacaactt ccgtgtaaac cttgaaaatc
     2881 aggtccgtaa atggttaacg attagtgcca atatctctta ctcagactat acaagtaatg
     2941 gaggtggagc aatgggaaca ggtgcgaatc gtggtggtgt tattctggct gttatcaata
     3001 caccaactta tgcaccggta tgggatgctt tgaacccaaa tcagtattac aataatttct
     3061 atggagtcgg taatattaca aatccattgg aaaatatggc acgtgcgaaa aataacaagg
     3121 ataaggaaaa ccgcttactg gcatcgggta atatattgtt gactccattc ccggagctga
     3181 agttcaagtc tactcttact cttgaccgtc gcaatgccgt taataccact tttcttgatc
     3241 cgatttctac tgcctgggga cgcaatcagt atggtgaggg ctcggataat cggaatatga
     3301 acacagtttt gacatttgat aatgtgctga cttataataa aaatttcaag aaacatggct
     3361 tggaagtaat ggctggttcg tcatggacgg attcagacta ttcaaatagt tggatcaatg
     3421 gctctcacta tcgtagcgac ctgattcaga cattgaatgc tgccaataaa atatcctggg
     3481 ataatacagg tacgggtgcg tctcaatggg ggattatgtc atttttcgga cgtgtagctt
     3541 ataacttcga tagtaaatat ctgctaacag ctaatcttcg tgccgatggc tcttctaaat
     3601 tacatcccga tcatcgttgg ggcgtatttc cctcattttc tgctgcctgg cgtatttctt
     3661 cggagaagtt catggagaac ctgacatgga ttgacgattt aaagttgcgc ggtggctggg
     3721 gacaaacagg taaccagtcg ggtattggtg actatgcata tttgcagcgt tacaatattg
     3781 gtcgtatcga atggttcaag aaaggcggtg aaggtgattc gactgattac gcaaatgctg
     3841 ttcctaccat tagtcaggca aatttacgta catctgattt gacatgggaa accacgacac
     3901 agaccaatat aggtctggat ctgaccatat tgaatggacg gttgacgttt aatgcagact
     3961 attattataa gaagaccaaa aacatgttga tgaatgtatc attacctgct ggtgccgcgg
     4021 cagctacgtc tattgcccgt aacgagggtg aaatggtaaa taagggtttt gagctttcta
     4081 ttagttcgaa gaatcttcgt ggaggagcat ttacatggga tacagacttc aatatttctt
     4141 ttaaccggaa taaattgaca aaactggaat tacagaaagt ttattacgat gctaaaacag
     4201 cagatgtggt gaatgattat gtggtacgta atgaaccggg acgtgcttta ggaggtttct
     4261 acggttatat aagtgatggg gtagaccctg aaactggtga attgatgtat cgtgatttga
     4321 ataatgatgg caaaatatca tcttctgacc gtacttatat cggtgatccg aatccagact
     4381 tcacttatgg tatgactaat acgttttcat ggaaaggctt taatttaagt atctttatcc
     4441 aaggttctta tggtaacgat atttataacg cttcgcgtat tgaaacggaa ggaatgtatg
     4501 atggcaaaaa tcagtcaacc cgtgtcttga accgatggaa gattccgggt caaattacag
     4561 acatgcctaa ggctaatttc aaattactca attctaccta ttttgtagaa gatggtagtt
     4621 atctaagatt aaaggatgtt tccttgtcat acaactttaa aggtaaactg ttgaagaaat
     4681 ggggaattac ccgcctacaa ccttacttca cggctactaa cctgctgaca tggaccagct
     4741 attcgggaat ggacccggaa gtaaaccaat ggggaaacag cggtacggta caaggtatcg
     4801 attggggtac ttacccccat tgcagatcat acgtgtttgg tattaatgtt gaattctaat
     4861 gaaaggaaag attatgaaac taagaactat attttatgga ttaacctctg gtttgctatt
     4921 ggggctttct tcctgttcgc tgaattatga gccattagac acctattcgg atgtgacgga
     4981 aggagtgaca agtgatggta cgaaaattgt attcaaggat aaagcggcag ttgaaagcca
     5041 tttgacaacg ctttataatc aaatgcgtga ccgtcaggaa cactggtatg tggatttact
     5101 tcttattgca gaatcacatg ccgacaatgc ctatgcagga actacaggag cagaagttgt
     5161 tccgtttgag aataactcta ttgaaggttc aaactctgta ttggaacggg actggaaccg
     5221 gtatatggaa gacgttgccc gcgctaatat cttgatttgt aatattgacg cagtgacaga
     5281 taattcgttg actactgccg aacgtgctca atacaaggca gaagcaaaga tattccgtgc
     5341 catgataatg ttcgacatgg tacgtctgtg gggggatttt ccagtgatta ccaccgtagc
     5401 agaagatatt acctctgata atattgagga tgtatatccg caatatttcc cagaacagaa
     5461 tacggaactt gaagcttatc agcagattga aagagattta ttggacgctg tgcagtatgc
     5521 tccggataac acaccgggga ataaaacttt gtttaccaaa tctgtagccc gtaccttatt
     5581 ggctaagatt tacgccgaga aacctttacg tgattatacg aaagttatcc aatattgtga
     5641 tgaggtgaaa gctgacggtt ttgatctggt ggatgatttc agtgatttgt ttgggatgaa
     5701 tgctgcggga acagatgcga agatgcgtaa tacgaaagaa tcgattcttg aagcacaatt
     5761 tactcccgga gcaggtaact ggtgcacatg gatgttcggt cgtgatttgg taaattggaa
     5821 taacaatttc acatgggcga aatgggtgac tccatcacgt gacttgatta gtactttcaa
     5881 acaggaaggg gatgaagttc gtttcaaaga atctgttgtt tattatgatt gtggttggag
     5941 caactattat ccgtctgata attatccgtt catgtataaa tgccgttcgg cgaatagcag
     6001 catcattaaa tatcgctatg ccgatgtact gttgctgaaa gcagaagccc tgatcatgca
     6061 ggatacacct gatttggaag gagcagccga tattatagat gaagttcgcg atcgtgccaa
     6121 attgggagca ctttcttctt ctacccgttc aaataaagat gcattgctga atgctttgct
     6181 taaagaacgc cggttggaac tggcttttga gggacaacgc tggttcgatt tagtccgtct
     6241 ggacaaggta gaagaggtga tgaatgctgt gcatgcgaaa gattcaggac gcaaagcgca
     6301 agtttacact tatgataaga attcctaccg tttgcctatt ccacaatcgg taatcgacgc
     6361 gaatgataag attcatcaga atccgggtta ttaattcaac taaaaaacat agaaaactta
     6421 agattatgat agacatgaga aatatagcat tgactttttt aggatgtttc accatattag
     6481 ctgcatgcag caacagtgac gatgcggaaa aacctgtggc acccattccc accggagatg
     6541 tgactattta ttccaccacc aatagtctga ctcgcgattt gactcgtgat gccgttaatt
     6601 tcagtttgaa agataacttg gcgcctactt ccattacatt gaacccgact gaacaatatc
     6661 agacaatgga cggctttggc gtagctatca caggtgctac ctgttttaat cttctgcaaa
     6721 tgaaaccgga agaccgccat gctttcctga cggaaacgtt ctctgatgac aaaggcttcg
     6781 gatttagcta tatccgtatc tctattggtt gctcggactt ctcattgagt gaatatactt
     6841 gttgtgataa gaaaggtatt gaaaattttg ctctacagag tgaagaaaaa gagtatattc
     6901 tgcctattct gaaagagatt ctggacatca atccttctat aaaaattatt gccgcacctt
     6961 ggacatgtcc aacatggatg aaggtgaaaa gcctcacaga ccttactcca tttgagtcat
     7021 ggacaaacgg tcagctcaat cctgcctatt atcaggatta tgccacttat tttgtaaaat
     7081 gggtgcaagc cttcaacgct gagggtattg atatctatgc cgtaactcca cagaacgaac
     7141 cgttgaatcg tggtaattcc gcttcacttt atatgagttg ggaagaacag agagacttcg
     7201 taaaaacagc acttggtcct aaattcaaaa cagccggatt agctacgaag atttatgcat
     7261 acgatcataa ttatgattat agcgatattg aaacagaaaa gaactacccc ggtaagatgt
     7321 atgaagaccc ggctgcttcc caatatctgg ccggagctgc ttatcacaac tatggcggca
     7381 accgcgaaga acttttgaat atgcacaaag cttatcctga aaaagaactt cttttcacgg
     7441 agacttctat cggaacctgg aacagcggac gcgacttgtc gaaacgattg ctggaagata
     7501 tgaaggaagt tgcattgggt acaatcaata actggtgtaa aggtgttatc gtatggaacc
     7561 tgatgcttga taatgaccgt gctcctaacc gtgaaggcgg ttgccagact tgctacggag
     7621 cagtggatat cagtaatagc gactataaga caattatccg taactcacat tattatatca
     7681 tcgctcatct ttcaagtgta gtgaaaccag gagccctacg tatcggtgcc acaggttatg
     7741 ccgacagcaa tatcatgtat tctgctttcg agaatccgga cggaacatac gcttttgtcc
     7801 tgatgaataa caatgaaaag accaagagaa taacctttag tgacggcaag cgccattttg
     7861 cttatgatgt tcctggcaaa tctgtgactt cctatcgttg ggcaaagtcg gaataagaac
     7921 cttaaaacga tcaaaacaat gaaaaaaaat atttatatca tattagctat ggcaggaata
     7981 ttatccatga attcctgcag tgatgacgaa ttcttgcccg gtagtccgag tatggaaatc
     8041 aaagcggaga atgcagatgc tctttttggt gacagtcttc cgtttacgat taaagcttcg
     8101 gacgtggatg tacctctttc taccttgaaa gcacagcttt tttatggaga agaacaagtg
     8161 tccgaaacgg tcatccgtac aaagacaagc ggaaacgatt atactggtaa aatcttcatt
     8221 ccttattatg ctaatattcc taatggaaag gcaaccttga aatatattct tcagaatatt
     8281 cactttacta caacagaaat gacgaaagag ctcgctctgg cacgaccgga ctttccctat
     8341 ctgacattag tggatgaaga gggaaaagag taccggatgg aacggcaatc catgtaccag
     8401 tatagcgtga caggagattt ttctcaaaag atgaaggcat atatcaaaac tccgaaagtg
     8461 ggagagaatg gcaacgaatt gactttcggt tgggacaatg ggacgattga aaccggttca
     8521 actaactcta tctctttttc taatacggaa ccggggagct atgctattaa atttaatacg
     8581 ttgacttatg aagcagagcc atttgctaaa ttgaaggtga acggtgaaga catggagctg
     8641 gtagagaatg atatttatgc aatcaaactc gctttgaaga agaatgatat tctaacgttt
     8701 gaaggggtac ctgattatga taattggtgg atagatcagg attattttga gaagcaggaa
     8761 gatggaacat tgaaattcct tccgattgat ggaagttacc aaataacggc aaatggtaaa
     8821 ctgaaatatt tctctgtcat tgctttgaag aatggtgagg ctgccaagtt gcaggaagat
     8881 ggaacaggtg ctatctgggc tattggaaca ggaatcggca agccatcggt tgcactttct
     8941 gaagtaggat ggactccgga aaacggtctg tgcatgccgc agcttactgc gaaaaagtat
     9001 caactgacat tcatagccgg agtaacaatg aaagtggatg atatcaactt taaattcttc
     9061 tatatcaata aatgggacaa tggcgagttt aaaggagatg ctatttctac aacgagcgaa
     9121 ttggttaaaa tctcttcaga cggtaacctg ggactgcaag aaggacagaa gttcgaaaga
     9181 ggaggcattt acagatttac agttgatgta acaaaaggca ataccaaggc tgtgttgaca
     9241 gtggagaaag tagggaaggt agatttaccc gcaccggata tcttctttgg taatagtaag
     9301 atggaggtga cagatactga tatatataag tcggatcagg tgtttacacg tggtcaaatg
     9361 ataactgtca ctggcattga taatttgaat gagtggtgga ttgatcctga cttctttgag
     9421 aaacaaagtg atgggacatt gaagtttctt cctattaatg gagattatcg ggtgacagct
     9481 aatggtatct tgaaatattt ctctgtaata gctttgaaag atggtaaacc ggccaaatta
     9541 caagatgacg gaacaggtgc aatttgggct atcgggaaag gaatcggtaa accttctgtt
     9601 acatcttccg aagtgggctg ggagacaggt aaggctctct gtctggcaca agttgctcct
     9661 aaaaagtatc agctaacctt gaaagccggg gaaacactga agactagtgg tgactgggag
     9721 gcgattagtt ttaagttctt ctatcaaaat gattggggag gagaattcag taattatgca
     9781 agtaatactt tagtggaaca gcttaaactt acaggctccg gaaacttgga aatgcaggat
     9841 aataaagcat ttgaagaagg aggtgtttat cgatttacca ttgatgtcac gaatggtaat
     9901 gctaatgcta ttctgaaggt tgagaaaata aattgatctg aagattgata tcggattttt
     9961 attgaaacta tcctgaaagg gtgtaatagt accctttcag gattcatctt agactgaata
    10021 acgtaaaaaa cattaataaa ctcatccgca actaggaaat attccccatt tgagagtcta
    10081 tataaataaa gtatgaactt atttcttata tcataaatga acatgaaatt caaagcaatg
    10141 ttacttggct tgtctgtgat aactgcgctg cctgcctttg cgcagaagcc ggtgtatctg
    10201 gatactggta agcctattga agagagagtg aaagatgcat tgaaccggat gacccttgaa
    10261 gaaaaggtga agatgattca tgcacagtct aaatttagtt cggcaggcgt tccccgcctc
    10321 ggaattcccg aagtatgggc taccgacggt cctcacggta tccgtccgga agtgttgtgg
    10381 gatgaatggg atcaggctgg atggacaaac gattcctgta ttgcctatcc ggcactgacg
    10441 tgtctttctg ctacatggaa tcccgaaatg tcgcatcttt atggaaaaag tatcggtgaa
    10501 gaggcacgtt accgcaagaa agacatcttg ttgggtcccg gtgtgaatat ctaccgtact
    10561 cccttgaacg gacgtaactt cgagtatatg ggagaagacc cgtatctgtc cgccactatg
    10621 gtggtgcctt acatcaaagg tgtacaagag aacggggtag ctgcctgtgt gaagcattat
    10681 gccttgaaca atcaggagtt caaccgtcat accaccaatg tgcaattgag tgatcgtgct
    10741 ctttatgaaa tatacctgcc tgcttttaaa gcggctgtcc aggaaggtgg aacatggtcg
    10801 attatgggct cttataatct ctatcaggga gagcacgcct gtcacaacaa gcgcctgctt
    10861 cgagatattc ttcgcgatga atggggcttt gatggcgtcg tagtgtccga ctggggaggt
    10921 gtgcacaaca ccgaacaggc tattcataac ggcatggact tggagtttgg ttcttggacg
    10981 aacggactgt ctgccggaac gagaaatgcg tatgataatt attaccttgc ttttccttac
    11041 ctgaaactga taaaagaggg taaagtagga acaaaggaac tggacgaaaa ggttagcaat
    11101 gtccttcgtc tgattttccg tacttcaatg gacccgcaca aaccattcgg ctctttaggt
    11161 tctcccgagc acgggcaggc cggacgtgag atagctgaag aaggaattgt gctgttgcag
    11221 aacaacggta acgtattgcc tatcgatttg aataaagcga agaaaatcgc agtggtcggt
    11281 gaaaatgcga taaagatgat gactgtgggc ggtggtagtt cttctttgaa agtgaaatat
    11341 gagatttctc cattggatgg actgaaaagc cgtgtgggtt caaaagcgga agtggtgtat
    11401 gcccgtggat atgtcggcga tccgacagga gagtataacg gtgtgaaaac cggtcaggac
    11461 ttgaaagaca accgttcgga agatgaactg ctcgctgagg ctttgcaagt ggctaaagat
    11521 gccgactatg ttatcttctt cggtggcttg aacaagagta atcatcagga ttgtgaagat
    11581 tcggaccgtg cttctttagg tttgccttac gcgcaggata gagtgataag cgaactggca
    11641 aaggtgaata aaaacctgat tgttgtcaat atctccggca atgcagtggc tatgccttgg
    11701 gtgaatgaag tgcctgctat tgttcagggt tggttcttgg gttcggaagc cggaacagct
    11761 cttgcttctg tattggtggg agacgctaac ccttcaggga aacttccttt caccttccct
    11821 gcaaaactgg aagatgtagg tgctcataaa ctgggcgaat atcccggtaa taaagaagag
    11881 ctggcacagt ctaaacatag aggggacacc attaatgaaa tctatcggga agatattttc
    11941 gtaggttatc gctgggcgga taaagagaaa atcaaaccgc tgttcccgtt cggacacgga
    12001 ttgagctaca ctactttcgc ctatggaaaa ccctcggccg acaagaagac aatgacagca
    12061 gatgatacca tctctttcac ggtcaatgtg aagaatacag gcactcgtga aggtcaggaa
    12121 gttgttcagc tttatatcag tgataagaaa tcctctctcc ctcgtccggt aaaagagttg
    12181 aaaggtttcc aaaaagtgaa actggctccg ggcgaagaga aagcggtaac gctgacgatt
    12241 gataagaaag cattgagctt cttcgatgat gccaagcacg aatgggtggc cgaaccgggc
    12301 aaatttgagg caatcatcgg tagttcatcc agagatatta aaggtattgt accatttgag
    12361 ttgaaatag
//
