LOCUS       AE007317               10272 bp    DNA     linear   BCT 30-JAN-2014
DEFINITION  Streptococcus pneumoniae R6, complete genome.
ACCESSION   AE007317
VERSION     AE007317.1
DBLINK      BioProject: PRJNA278
            BioSample: SAMN02603218
KEYWORDS    .
SOURCE      Streptococcus pneumoniae R6
  ORGANISM  Streptococcus pneumoniae R6
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10272)
  AUTHORS   Hoskins,J.A., Alborn,W. Jr., Arnold,J., Blaszczak,L., Burgett,S.,
            DeHoff,B.S., Estrem,S., Fritz,L., Fu,D.-J., Fuller,W., Geringer,C.,
            Gilmour,R., Glass,J.S., Khoja,H., Kraft,A., LaGace,R., LeBlanc,D.J.,
            Lee,L.N., Lefkowitz,E.J., Lu,J., Matsushima,P., McAhren,S.,
            McHenney,M., McLeaster,K., Mundy,C., Nicas,T.I., Norris,F.H.,
            O'Gara,M., Peery,R., Robertson,G.T., Rockey,P., Sun,P.-M.,
            Winkler,M.E., Yang,Y., Young-Bellido,M., Zhao,G., Zook,C.,
            Baltz,R.H., Jaskunas,S.Richard., Rosteck,P.R. Jr., Skatrud,P.L. and
            Glass,J.I.
  TITLE     Genome of the bacterium Streptococcus pneumoniae strain R6
  JOURNAL   J. Bacteriol. 183 (19), 5709-5717 (2001)
   PUBMED   11544234
REFERENCE   2  (bases 1 to 10272)
  AUTHORS   Hoskins,J.A., Alborn,W. Jr., Arnold,J., Blaszczak,L., Burgett,S.,
            DeHoff,B.S., Estrem,S., Fritz,L., Fu,D.-J., Fuller,W., Geringer,C.,
            Gilmour,R., Glass,J.S., Hann,A., Khoja,H., Kraft,A., LaGace,R.,
            LeBlanc,D.J., Lee,L.N., Lefkowitz,E.J., Lu,J., Matsushima,P.,
            McAhren,S., McHenney,M., McLeaster,K., Mundy,C., Nicas,T.I.,
            Norris,F.H., O'Gara,M., Peery,R., Robertson,G.T., Rockey,P.,
            Sun,P.-M., Winkler,M.E., Yang,Y., Young-Bellido,M., Zhao,G.,
            Zook,C., Baltz,R.H., Jaskunas,S.Richard., Rosteck,P.R. Jr.,
            Skatrud,P.L. and Glass,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUL-2001) Infectious Diseases Research, Eli Lilly and
            Company, Lilly Research Labs, Indianapolis, IN 46285-0438, USA
COMMENT     On or before Feb 19, 2009 this sequence version replaced
            AE008385.1, AE008386.1, AE008387.1, AE008388.1, AE008389.1,
            AE008390.1, AE008391.1, AE008392.1, AE008393.1, AE008394.1,
            AE008395.1, AE008396.1, AE008397.1, AE008398.1, AE008399.1,
            AE008400.1, AE008401.1, AE008402.1, AE008403.1, AE008404.1,
            AE008405.1, AE008406.1, AE008407.1, AE008408.1, AE008409.1,
            AE008410.1, AE008411.1, AE008412.1, AE008413.1, AE008414.1,
            AE008415.1, AE008416.1, AE008417.1, AE008418.1, AE008419.1,
            AE008420.1, AE008421.1, AE008422.1, AE008423.1, AE008424.1,
            AE008425.1, AE008426.1, AE008427.1, AE008428.1, AE008429.1,
            AE008430.1, AE008431.1, AE008432.1, AE008433.1, AE008434.1,
            AE008435.1, AE008436.1, AE008437.1, AE008438.1, AE008439.1,
            AE008440.1, AE008441.1, AE008442.1, AE008443.1, AE008444.1,
            AE008445.1, AE008446.1, AE008447.1, AE008448.1, AE008449.1,
            AE008450.1, AE008451.1, AE008452.1, AE008453.1, AE008454.1,
            AE008455.1, AE008456.1, AE008457.1, AE008458.1, AE008459.1,
            AE008460.1, AE008461.1, AE008462.1, AE008463.1, AE008464.1,
            AE008465.1, AE008466.1, AE008467.1, AE008468.1, AE008469.1,
            AE008470.1, AE008471.1, AE008472.1, AE008473.1, AE008474.1,
            AE008475.1, AE008476.1, AE008477.1, AE008478.1, AE008479.1,
            AE008480.1, AE008481.1, AE008482.1, AE008483.1, AE008484.1,
            AE008485.1, AE008486.1, AE008487.1, AE008488.1, AE008489.1,
            AE008490.1, AE008491.1, AE008492.1, AE008493.1, AE008494.1,
            AE008495.1, AE008496.1, AE008497.1, AE008498.1, AE008499.1,
            AE008500.1, AE008501.1, AE008502.1, AE008503.1, AE008504.1,
            AE008505.1, AE008506.1, AE008507.1, AE008508.1, AE008509.1,
            AE008510.1, AE008511.1, AE008512.1, AE008513.1, AE008514.1,
            AE008515.1, AE008516.1, AE008517.1, AE008518.1, AE008519.1,
            AE008520.1, AE008521.1, AE008522.1, AE008523.1, AE008524.1,
            AE008525.1, AE008526.1, AE008527.1, AE008528.1, AE008529.1,
            AE008530.1, AE008531.1, AE008532.1, AE008533.1, AE008534.1,
            AE008535.1, AE008536.1, AE008537.1, AE008538.1, AE008539.1,
            AE008540.1, AE008541.1, AE008542.1, AE008543.1, AE008544.1,
            AE008545.1, AE008546.1, AE008547.1, AE008548.1, AE008549.1,
            AE008550.1, AE008551.1, AE008552.1, AE008553.1, AE008554.1,
            AE008555.1, AE008556.1, AE008557.1, AE008558.1, AE008559.1,
            AE008560.1, AE008561.1, AE008562.1, AE008563.1, AE008564.1,
            AE008565.1, AE008566.1, AE008567.1, AE008568.1.
FEATURES             Location/Qualifiers
     source          1..10272
                     /organism="Streptococcus pneumoniae R6"
                     /mol_type="genomic DNA"
                     /strain="R6"
                     /db_xref="taxon:171101"
     gene            complement(1..1194)
                     /locus_tag="spr1708"
     CDS             complement(1..1194)
                     /locus_tag="spr1708"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q97NW6|9.B.67.1.2"
                     /protein_id="AAL00511.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIISL
                     IFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQSIL
                     SHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFFNPN
                     YYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAGAIIY
                     LFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMALFKQNP
                     FWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRLMMDMSQ
                     ESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLVSDMTD"
     gene            complement(1332..2774)
                     /gene="gtfA"
                     /locus_tag="spr1709"
     CDS             complement(1332..2774)
                     /gene="gtfA"
                     /locus_tag="spr1709"
                     /EC_number="2.4.1.5"
                     /codon_start=1
                     /transl_table=11
                     /product="GH13|GH13_18"
                     /protein_id="AAL00512.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFGDAIGGVHLLPFFP
                     STGDRGFAPVDYDEVDSAFGDWEDVKRLGERYYLMFDFMINHISRQSKYYKDYQEKHEA
                     SEFKALFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEEQID
                     LDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLDKVRD
                     IAAEYGTELLPEIHEHYSIQFKIADHDYYVYDFALPMVTLYTLYSSRTERLAKWLKMSP
                     MKQFTTLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNLDIYQIN
                     STYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGRNINRHYY
                     SNEEIAKEVQRPVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQNKDKSVTA
                     VVEIDLQNQTYRVIENGVEVTF"
     repeat_region   2980..3130
                     /note="Box_ABC"
                     /rpt_family="BOX element"
                     /rpt_type=dispersed
     gene            complement(3132..3965)
                     /gene="msmG"
                     /locus_tag="spr1710"
     CDS             complement(3132..3965)
                     /gene="msmG"
                     /locus_tag="spr1710"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00751|3.A.1.1.28"
                     /protein_id="AAL00513.1"
                     /translation="MKQDERKALIGKYILLILGSVLILVPLLATLFSSFKPTKDIVDNF
                     FGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRKAF
                     TIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGYIKI
                     SIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVLNRDS
                     KMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIISGMSNGAVK"
     gene            complement(3979..4869)
                     /gene="msmF"
                     /locus_tag="spr1711"
     CDS             complement(3979..4869)
                     /gene="msmF"
                     /locus_tag="spr1711"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00750|3.A.1.1.28"
                     /protein_id="AAL00514.1"
                     /translation="MWIRSRETMKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSF
                     TNWTGLTYNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSK
                     IKGQTFFRSWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIF
                     AAVFVLLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSIV
                     FILALKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIV
                     VISIIQLRVSKKFEI"
     gene            complement(4859..6118)
                     /gene="msmE"
                     /locus_tag="spr1712"
     CDS             complement(4859..6118)
                     /gene="msmE"
                     /locus_tag="spr1712"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00749|3.A.1.1.28"
                     /protein_id="AAL00515.1"
                     /translation="MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKEM
                     TKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEWAK
                     AGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKVPET
                     WDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQPNAI
                     KLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAITAINE
                     QKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPEVMQKYY
                     DVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTMNYVLTGD
                     KEGMVNDLNAFFNPMKADVD"
     gene            complement(6210..8372)
                     /gene="aga"
                     /locus_tag="spr1713"
     CDS             complement(6210..8372)
                     /gene="aga"
                     /locus_tag="spr1713"
                     /EC_number="3.2.1.22"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="AAL00516.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSNS
                     VYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVEAK
                     ILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLDNNS
                     NQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGASGHAQ
                     TPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSWKLAPE
                     EYFETPVALVTHSDQGLTGISHESQNFVLKHIILSEFSKKERPILINNWEATYFDFQRE
                     KLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLISAIHERG
                     LQFGLWLEPEMISVDSDLYRQHPDWAIQVPDYEHTYSRNQLVLNLANPQVVEYLKSVLD
                     QLLSYHEIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLTEKHSHILFE
                     SCSGGGGRNDLGMIRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGAHVSAVPNHQM
                     GRMTPLETRGHVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPVVQLGQQYRLIN
                     PDTASNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLYKLQENGEVYSGA
                     ELMYAGLTVILSQGDFLSRQYIFRKL"
     gene            8480..9340
                     /gene="msmR"
                     /locus_tag="spr1714"
     CDS             8480..9340
                     /gene="msmR"
                     /locus_tag="spr1714"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_AraC,DBD-Pfam|HTH_AraC,DBD-SUPERFAMI
                     LY|0036286,DBD-SUPERFAMILY|0035607"
                     /protein_id="AAL00517.1"
                     /translation="MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYISK
                     GQGKFHYKGKIVDLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALSQI
                     SDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIAPNQ
                     KKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSPKEYL
                     LYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQSPSHTRKEYSQYQLV
                     RKATL"
     gene            9337..10272
                     /gene="birA"
                     /locus_tag="spr1715"
     CDS             9337..10272
                     /gene="birA"
                     /locus_tag="spr1715"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_11,DBD-SUPERFAMILY|0039384"
                     /protein_id="AAL00518.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTSIWKAIKRLEQEG
                     IEINSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANTLY
                     LASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNLTLI
                     DVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKEKAAS
                     LFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYKGLAKD
                     ISENGKLLVQCDNGKEIWLNSGEISLNSWK"
ORIGIN
        1 ttaatccgtc atgtccgata ccaacattcg atgctccaat ggaatactgc acataactag
       61 caagaaaata aagcctgact gaatccagaa gagagccaag tcaaaaattc cgtgcacagc
      121 aaccactgta aggaaagata gataaaggcc gataatcgga cgtttccccg actcctgact
      181 catatccatc atcaagcgaa caggagcaac agaagacaaa actaataaaa tggtacccac
      241 aattccgtaa ctcagaatcg tatcaatata aagactgtgg gcatgttcat gataaggagc
      301 atgtatccga ggataagagt gcatataggt caatggccct tcaccccaaa aaggattttg
      361 cttaaacaag gccatcccag catcccagat agaaatgcgt tcttccatag aagagtctaa
      421 agtacccatt cgaactccca aatcactaga aaagaggaaa ctcaaaccaa tcgcgaagac
      481 cccaatacta agccaaaagg ccttccagtt tttaatagtc gtaaagagat agataattgc
      541 tccagcgata atagcaggaa aggcagttcg attttgagta aagttcaaac caaagagatt
      601 aacaaagcct gcaatcacac agaatacttt caaccaattc aacttggtcg ttgtaaacag
      661 atagaaagca atcataatac agaaacaaca aataattcca taataattag gattaaagaa
      721 ggtcacttct gcccggttct gatgccacac ctgcatattg ggtgaaagaa aagcatagtt
      781 aaatttcttc acaatttgga aatgttctaa actggcaaaa gcagctgaca agacactacc
      841 aaacaagacg aactgcaaaa tcaatcgaaa gaatttatgg gataaaatcg actgatagtg
      901 caaaaagaaa atagtaaata gaaacattcc tactgaagcc acaagaccca tccaattttg
      961 tgcaagaatg gatataacag tactatagct aagaaaaaga agcagcatcg gatgctcccc
     1021 cattttctga agaatacttt tcatgtctcc tgtaaaaatc aaactgataa tatataaaca
     1081 gagtacaact acaaaaagat aaaagggtaa aaagatactt aggataattc ccaataaaat
     1141 cagctcttta ctagacaacc ccttcagctt ttcaataaag cctattgatt tcaaaatgaa
     1201 tcctttctct ccaaatctgc tgattcagat aatagtaagc tatcctatat tgtaccactt
     1261 ttttagcaat ttgaaaacaa aggaaacgtt ttccaaaata aaaaccctat tttatccacc
     1321 atatcaaggc ttcaaaatgt tacttcaact ccattctcaa ttacccgata agtctgattt
     1381 tgcaaatcaa tttctactac tgctgttacg gacttatctt tattttgacg tttgattaca
     1441 atgctgtgag ctgttggtgt ctctatctca gtagtcccct ctagatcaaa ggcttctgaa
     1501 cggttacgga aagaaaatag attgagaagg gccttcacaa caggtcgttg cacttctttt
     1561 gctatttcct cgttgctata gtaatgacga ttaatatttc gaccttcttt agtttcttct
     1621 aataatttca agtcattctt gcctgctaat agacccacat agtaaacctg aggaatacct
     1681 ggggcaaaag cttgaattag acgagcgaga aaatacttga catcatcatc tccaagcgct
     1741 gaatagtagg ttgaattgat ttggtagata tctaagttgt tatactcggc actagagtac
     1801 ttacgtttga cattggctcc aaccttatag agttcatttg aagcatagtc aatctcctca
     1861 tcggtcagga tatccttgac atctactact ccaatcccat catgggtatc tagcgtcgta
     1921 aattgcttca tcgggctcat ctttaaccac ttagccaaac gctctgttct ggaactgtaa
     1981 agagtataaa gtgtcaccat tggaagagca aaatcataaa catagtaatc atggtctgct
     2041 attttaaact gaatcgaata gtgttcatga atctcaggta aaagctctgt cccatactca
     2101 gcagcgatat ctcgaacttt gtccaataaa tcccaaatat ctggttccac aaagaaatca
     2161 ttagtatcca atttcttcac tgcataagca aaggcatcta gacgaatcaa atcacaccca
     2221 ttacttgcca agtgctgaat ggtcttacgg ataaattcca tagttacttc tttggtcaca
     2281 tcaagatcaa tctgctcctc accaaaggta ttccacaaat gttccactga accatcttca
     2341 aacacaatct cttgctttgg tgcacgatcc ttacgcttgt aaattaaatc tacatcagac
     2401 tgtgtcggac ggttttctgg ccaaaactta tcccagttta aaaagagagc tttaaattca
     2461 ctggcttcat gtttttcttg atagtcctta taatacttgg attgacgaga aatatgatta
     2521 atcataaaat caaacataag ataatatctc tcacctaaac gcttaacatc ctcccaatca
     2581 ccaaaagctg agtccacttc gtcgtagtca actggcgcaa atccacgatc acctgttgat
     2641 gggaaaaatg gtaaaaggtg aactcctcca atagcatctc caaaatgctc ttccaaatta
     2701 tcatataagt ctttaagatt atttccaagg ctatcagaat aggtaatcaa catggtttta
     2761 ttttgaattg gcatcattac tctccttttt ctaattgaag ccaagtctca tatgatctgg
     2821 cttcataaat aaaattcatt ttaaatctct atttatcatc aaactcgtac taatatagac
     2881 tgtgataaac aaagtactac tttcttgttt tctacataga attatcaaca agctgaactc
     2941 ttcctctgtg tcaaagacta tagattccat gagctcttct tatactcttc gaaaatctct
     3001 tcaaaccacg tcagcttcac cttgccgtag gtatggttac tgacttcgtc agtttcatcc
     3061 acaacctcaa aacagtgttt tgagcaacct gcggctagct tcctagtttg ctctttgatt
     3121 ttcattgagt attacttcac tgccccgttg ctcattcctg aaatgatatg gcgttggaag
     3181 aagagataga caatggtgat actgataatg ccgaccacgt aagaggcaaa gcttggtccg
     3241 tagtcgttga aatattggcc tgcgtagttg tattggaaca aaggcagagt ccacattttg
     3301 gaatcccggt tcaagacaag gagtggcaac atgaagtcat tccagaacca aagggcattg
     3361 atgatcatgg ttgtcgcatg catcggtttc atcattggga agatgatgcg gaaataggtt
     3421 gtaaattgat tagccccatc gatctctgct gcttcatcca gactttctgg aatcgagatt
     3481 ttgatatagc caacatagag aaagagggtc tgtggaatcg cataggtcaa gtagagcaag
     3541 atcaaaccaa aggtattagc caaaccgagt ttactcatca taaccgtaat cggaatcatg
     3601 atgacttgga aaggtacgaa gattccgagg attaagaggg tatacatgat ggtaaaggct
     3661 tttcttttac tcatattgcg agcgatggag taggctgcca tagggataaa gatcattact
     3721 gcaagtaaag acaagacagt gatgacgaca gagttccaat aatagcctcc aatcccatca
     3781 gctaagagac ggctaaagtt gtcccatgtg aagttggttg gaaagccaaa gaaattatct
     3841 acaatatcct tagtgggttt gaaggaacta aagagggtag caaggagcgg cactaaaatc
     3901 agaaccgatc ctagaatcaa tagaatgtat ttgccaatca gggcttttct ttcatcttgt
     3961 ttcatcatgc ttctcctctt aaatttcaaa tttcttagat actctcaatt ggatgatcga
     4021 aatcactaca attaagaaga acaagattac ggcaatggca ttggcataac cgaattggtt
     4081 gtttttaaag gcatagttat aaaccaagag cccaagtgag gttgtggcat tgtttggacc
     4141 accaccggtc atggcaaaga cttggtcaaa ggcagtcagc ccacctttta gggctaggat
     4201 aaagactata gagacacttg gtagcaagta aggcaattca atgttccaga aaacttgctt
     4261 gctagtcgca ccatcaatcc ttgctgcctc tgtaatctca gttggaatag attgcaaacc
     4321 agctaggaag atgatgatgg gcatagccac cccttgccaa agaaggacaa agacagccgc
     4381 aaagattgct ccccacttag tccctaaaag actggtttgg agaaattcaa tatgaagggc
     4441 attcccaatc gctggaagac cgtagttgaa gacttgcttg aagatcaaag ccactgtcaa
     4501 accagataaa acagctggga agaagaacca agaacggaag aaggtttggc ctttgatttt
     4561 agagttcaag acacgcgcaa tgaagatccc gagtgcaatc tcaccaacca ccatggcaat
     4621 cgtaatgatt gcggtaaagc caatcgcatt catgaatttt ggatccatga agaggagctt
     4681 aaagttgttt aagccgacaa atttgtagtt ataagtcaat cctgtccagt tggtaaaact
     4741 gtaaaaggct ccttgaaaca tcggcacata gaagaaaatt gcttgtaaca agagggggat
     4801 gaccacaaaa gcccatgccc aatatttttg taatactttt ttcatagtct ctctactcct
     4861 aatccacatc cgctttcatc gggttaaaga aggcattcaa atcattgacc atgccttctt
     4921 tatcaccggt caagacatag ttcatggtca aggtatggaa gtctgcttca ctggtccagt
     4981 attgttgcaa ccagaccaag tgacgatccg taaaggcata ttcggtcata ccagcaagcg
     5041 gtgaatcttc tcctgcttgt ttgacccctt cgatcgctgt tggagatccg tccacatcgt
     5101 agtatttttg catgacttct ggacgggtca tatattccac aaaggcattg gcttcttttg
     5161 gatgtttggt ggtggctgag atagaccatg ccaagtctcc cgcaccaacg gttaagcttt
     5221 gtcctttttc ttttcctgga atcatgaagg tcccaatctt aaagttcggt ttttgttcat
     5281 taatcgctgt gatcgcccaa gacccatttg gtgtcatgag gacatcccca cgtgcgaagg
     5341 ctccgataac atcggtatag ccagcacctt cccagttctt ttgcttagag ccattgatgc
     5401 gaaggatgtc catgaccttg atatcatctt tcataatcgg atccgacaat ttaatggcat
     5461 ttggttgaga ataacgaagg tattgatttg cttcttttcc tccacctgtt gctgtcgcaa
     5521 aggctaattg attgtaacca ttgagtgtcc aagcatctgc acctgcaatt ccaaatggtg
     5581 tttgtccttt agcaacgata tctttgacta actgttcaaa ttcatcccag gtttcaggaa
     5641 ccttcaagcc cagttcttcg aatttatctt tgttgtagta aattccataa gcattagctg
     5701 taaaaggaac gttgtaaact ttttcgttta cagcatattt ttcagcgtag ccatttttca
     5761 cgcgtttcag gtagtctttg ttgctcaaat cttcaaaaac acctgctttt gcccattctt
     5821 gcagttcgat ggactgtggg taaatattga ccacatcagg cacatctcct gcgagaacgc
     5881 gtgtcttcaa tacttcacca gcatttggta cattgacgac tttgaccttg atcttagggt
     5941 tttccttctc aaaatcacga gtgatttctt ccaaggtttt ggtcatttct tttttctggt
     6001 tgaaatactc gatggtcact gtgccatccg cagatttacc atagttggag caagcgccga
     6061 gcccaaacaa agctaaacct gtagttgcaa gaagtccgat ttttttatac cattccatta
     6121 gaaagcctcc tttataaatt tatacaccct tattgaactg caccccaaaa gttagacaga
     6181 ataaatctaa cttttggggt cagtacatat catagttttc taaaaatata ctgtctactc
     6241 aaaaaatctc cttgggataa gataacagtt aagcccgcat acattagttc tgcacctgag
     6301 taaacttcgc cattttcctg taatttatat agtccctctt catccaaatc ttttaatttt
     6361 aaagttgttt ccatggtctc tacaacagat aaaacgcgaa cgtaggttac aatcgtttga
     6421 tttccgtaat taaattgtac agctgcttca ttggatgcag tatcaggatt aattagtcta
     6481 tactgctgtc ctaactgaac tactggtcgt aattctttat acaagttcac ctgattagca
     6541 atcgtagctt tctcttcatc tgataaattt gtcaaatcaa gctcatagcc caaatttccc
     6601 atcattgcta catggccacg tgtttctaat ggtgtcattc gtcccatctg atgattcggt
     6661 actgctgaca catgagcccc catagaaatg gttggataga gataggatga accgtattga
     6721 attggtaaac gtgcaatggc atcagtatta tcactagccc agacttgtgg gaaatagcgt
     6781 atcataccaa gatcatttcg tccaccacca ccagagcagg actcaaagag aatatggctg
     6841 tgcttctctg tcagataaga aacgagttcg taaagtccca gcatgtactg atgagattgc
     6901 atctgtgtct ctagataagt taatccattc cctagcttag tgatattgcg gttcatatcc
     6961 catttaatgt aatcaatctc atgataagat aggagttgat ctaagacact tttcaagtat
     7021 tctactacct gaggattggc aagattaagt actaattgat tccgagaata agtatgctca
     7081 taatcaggaa cctgaatagc ccagtcagga tgttgacgat acaaatcact atctacagaa
     7141 atcatttcgg gttctaacca aagtccaaac tgcaaacctc tttcatggat agctgaaatc
     7201 agactttcta gacttccacc cagtttttcc tcattaacaa cccaatcacc taaagcacga
     7261 ttatcatcaa aacgattgcc aaaccaacca tcatctaata caaaaagttc aatgccaact
     7321 ttcttagctt catctgctaa ctctaacagt ttttctctct gaaagtcaaa gtaagtagct
     7381 tcccagttat tgattagaat tggacgttct tttttagaaa attcacttag aataatgtgc
     7441 ttcagtacaa aattctgact ttcatgacta ataccagtta atccctgatc tgaatgagtc
     7501 actaaagcta ccggtgtttc aaagtattcc tcaggggcta acttccaaga aaagttttct
     7561 ggattaatgc caatagccac ccgaacttca ttcaattgat ttttttgaac aaaagcttca
     7621 aagttgccac tatacattag ttgaatagca aacacattcc cagcatcctc tgtgactcct
     7681 tgttcgcata gtagaagagc tggtgtttga gcatgaccag aagcacctcg gtttgaacta
     7741 atcgaaaaga ttccttgttc tacctgttga cgtctaacag tcttttcacg agcataagca
     7801 ccctgcagag ttactatttc gtaatctgca gctggaaaat cagccataaa agaaaaatct
     7861 ttatggatga caacttcctg attactatta ttatctaatt tactgtagct agcaatagtc
     7921 gcatcattat taaaagtagt ataatacaaa gtcagactaa gttgagcctt agaatcttct
     7981 aacattaaga caagagtctc tgtatcgtcc atgctatgtg gagaaggtaa gccctgtgga
     8041 ccattctgac cttttaaaat ctttgcttct acaaatcgaa agtctgttac ttcagttaca
     8101 ctatgctgaa cctgtatagt tggtttccta aaatctccta agccatgttg tccaaaaatc
     8161 tgtcgctgag tatctaaact aaaggttcga ttagtagccg ttggatttcc tgaaaaggca
     8221 tggtctcgtt cataaacact attggaacct ttatagttct taatagtctt tcctaaatgt
     8281 ttcaaaagta agtagccatt tcgattttca ataatcaaac ttagattttt actctcaaca
     8341 taaaatagat tattctctat cctaactccc atttacttca cctcatcact ttattgatta
     8401 tattttatca cctgaaatcg ctttccaaaa tagaaaaatg tctcaagaat atggtaaaat
     8461 gttaggtagg aggtagcaca tgctagtttt ttcagaatac cagactggaa caattgacct
     8521 tgccctaagc ttttatggat atgaggaatg cacacctaat tactcttttg gtccagccat
     8581 tcgtgataca tacgtcctac attacattag taaaggacaa ggaaaatttc attacaaggg
     8641 taaaattgtt gatttaaaag aaggagattt ctttctatta aaaccagagg aactaacctt
     8701 ttatcaagca gatagtaaag aaccttgggc ctactactgg ttaggaatca ctggagggaa
     8761 atcccctgat tattttgctc tttctcaaat ttctgatcaa tcctatctca tccaatctga
     8821 aacttgtcat acccagacta ctgcaaaact catctcagac attgtccgct tcgctcagat
     8881 tacaaaatca agtgaattag ctcaactcca tatcatggga caacttcatg aactgatgtt
     8941 tcatctggga actattgctc ccaatcagaa aaaaaagaat atttcatcaa cccaccaact
     9001 ctatcttgaa tgcaaacgat taattgatag ccactatcct caatcactta caattcaaga
     9061 tttagcaaaa gaactatccg ttcacagaag ctacttatca agcgtattca aagaatttaa
     9121 taccttatca cccaaagaat acctactcta cgttcgaatg caccgagcta gacaacttct
     9181 cgaaaatacc caagagtcca tcaaggtaat tgcatactcg gtaggttttt cagatccact
     9241 ccatttttcg aaagcttata aacaatactt taatcagtct ccaagtcata caagaaaaga
     9301 atactctcaa taccaactag tgagaaaggc aacattatga aatcctacca agctgtctac
     9361 caaatcctat ctaaagaaac cgactatatc agcggagaaa aaatcgcaga aaaactatcc
     9421 ctaagccgaa catcaatttg gaaagctatc aagcgactag aacaagaagg cattgaaatt
     9481 aatagtatca aaaatagagg atataaacta atgaatggtg accttattct tccagagatt
     9541 ctagaagaaa atcttccaat taaagtcagc tttaaacccg aaacaaaatc aacacaacta
     9601 gatgcaaaag aagcaattga tttaggccat gaagcaaata ctctctatct agcttcctat
     9661 caaacagcag gccgaggccg ttttcaacgt tccttctact caccacaagg tggaatttat
     9721 atgacactcc atcttaaacc aaatctcccc tatgacaaat taccatccta cacactactt
     9781 gtagctggag ctgtctacaa agccattaag aacctaactt taatagatgt cgatataaaa
     9841 tgggtcaatg atatctatct aaacaatcat aaaattggag gaatccttac tgaagcaatg
     9901 acctctgtag aaactggctt agtcacagat atcattattg gagtaggtat caatttcact
     9961 attaaagact tccctcagga attaaaagaa aaagctgcca gcttatttaa agctacagct
    10021 cctataacaa ggaatgaatt gatcatagaa atctggcgtg ctttcttcga aacaccagca
    10081 gaagagctat tatacctata caaaaaacag tcattcattc taggaaaaga agtcactttc
    10141 acactagagc aaaaagacta caagggactt gctaaagaca tctcagaaaa tggaaaactt
    10201 ttagttcaat gtgataacgg aaaagaaatc tggctaaata gtggcgaaat ttctctcaat
    10261 agttggaagt aa
//
