LOCUS       PJEE01000011           14957 bp    DNA     linear   BCT 11-DEC-2017
DEFINITION  Bifidobacterium longum strain APC1464 contig0011, whole genome
            shotgun sequence.
ACCESSION   PJEE01000011
VERSION     PJEE01000011.1
DBLINK      BioProject: PRJNA394834
            BioSample: SAMN07958349
KEYWORDS    WGS.
SOURCE      Bifidobacterium longum
  ORGANISM  Bifidobacterium longum
            Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
            Bifidobacterium.
REFERENCE   1  (bases 1 to 14957)
  AUTHORS   Arboleya,S.
  TITLE     Bifidobacterium longum APC/DPC strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14957)
  AUTHORS   Arboleya,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-DEC-2017) Microbiology, UCC, Western Road, Cork,
            Ireland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date          :: 01-SEP-2016
            Assembly Method        :: Velvet v. 1.2.10
            Expected Final Version :: yes
            Genome Coverage        :: 100x
            Sequencing Technology  :: Illumina
            ##Genome-Assembly-Data-END##
            Bacteria available from APC Microbiome.
FEATURES             Location/Qualifiers
     source          1..14957
                     /organism="Bifidobacterium longum"
                     /mol_type="genomic DNA"
                     /submitter_seqid="contig0011"
                     /strain="APC1464"
                     /isolation_source="fecal sample"
                     /host="Homo sapiens"
                     /db_xref="taxon:216816"
                     /country="Ireland"
                     /collection_date="30-Oct-2015"
     gene            1..345
                     /locus_tag="APC1464_1419"
     CDS             1..345
                     /locus_tag="APC1464_1419"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="PKD09594.1"
                     /translation="MDATTLSITLSAILAVICTPCGLFLGLVPMKADLVTAKQSKASQM
                     VSFIVAIVFIGLLVAGHDLETWAMVIGLVIGFAVAKIPALHAWALHKWPFFEPKKMAPT
                     PKRVKKARKK"
     gene            complement(608..790)
                     /locus_tag="APC1464_1420"
     CDS             complement(608..790)
                     /locus_tag="APC1464_1420"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="PKD09792.1"
                     /translation="MRAHHVLLLSLCLLAAAYAVLLFVSPAAAPIGVTLTVVGLVLVST
                     RYAWRAKFLALFNEA"
     gene            complement(981..2960)
                     /locus_tag="APC1464_1421"
     CDS             complement(981..2960)
                     /locus_tag="APC1464_1421"
                     /codon_start=1
                     /transl_table=11
                     /product="GH120"
                     /protein_id="PKD09793.1"
                     /translation="MTQYHVSAQAAKTNGAGSAADPFLTIGQAAAIARAGDEVVVHAGT
                     YRESVDPRFGGESATNRIVYRAAAGEPRPVITGSERIDTWQPEGDGVWKAVIPNAFFNG
                     YNPYVETVFGDWTVYPDPKVEVRHLGDVYLNGKSFYEVASLDKVRNPQRWDTGRDAATD
                     SIVPLINPDATVNVWCCAVDDEATTIWANFHEADPNAELTEINVRETCFYPSRPFVNYI
                     TVSGFEMAQAACPYTPPTADQVGLVGPHWSRGWVIENNRIHDAKCSAISLGKEISTGDN
                     ESTRTHRKSGYQYQKEAVYKALHAGWEKGVVGGHVVRGNVIYDCGQNGVVGHMGCAFSL
                     IEGNHIYRIGAKREFFGWEVAAIKMHAAVDTVVRGNRVHDSVLGMWLDWQAQGTVVDSN
                     VFYRNTRDVMTEVTHGPITFMNNVFASEFSFDDYAQGAAFVNNLFAGRIRHTAVLDRST
                     PYHFPHVTDVAGEAFVYGGDDRYVNNLFLAVDDSAKPLCTADAAGAAGMAEAGTAFFDG
                     YPRSLEEYEQLIEEAGLGDEELYRSVKQPVLLSSNAYVSGAKAASGEAEAVVSGDGSSL
                     ALRETDDELWMTVSLPESIRSATGPVISTADLGQPRIVEEYFENPDGSPIVVDRDITGA
                     ARGACSARGPLAAYGDGEVLIWSK"
     gene            complement(3023..3655)
                     /locus_tag="APC1464_1422"
     CDS             complement(3023..3655)
                     /locus_tag="APC1464_1422"
                     /codon_start=1
                     /transl_table=11
                     /product="galactoside O-acetyltransferase"
                     /protein_id="PKD09794.1"
                     /translation="MAHDLEQLKQDHPDVAKLFADDWLQYRKSEILPELTREAQSTCDR
                     INRIYFEDTAEAERLFRELVPEAGEGVDFRPPIRLDYGLGLKIGDRTFINMDLLIVGGG
                     PISIGSDCLIGPRVSIYTPNHAIARKPRLEGWQHNADVTIGNNVWLGGNVVICPGVTIG
                     DNSIIGAGAVVTHDIPADSIAVGNPCHVIAEVPDDWTPEERAAAEGR"
     gene            complement(3728..5500)
                     /locus_tag="APC1464_1423"
     CDS             complement(3728..5500)
                     /locus_tag="APC1464_1423"
                     /codon_start=1
                     /transl_table=11
                     /product="GH43|GH43_12"
                     /protein_id="PKD09795.1"
                     /translation="MASDNEHCGDRGRECTITVSNPVLRGMYPDPSWIWDTTREEIVLV
                     NSSFELVPGLPIHTTRDLVTWTRTANAVDETMSHRLLIDGVEDSGGLYAPTIRRIGGRY
                     VIVCTVARVDEVKALAAGCSQKDIDNCRDAQGNFVIEADELTGPWRGPYWVAGAEGIDP
                     DIFEDGDGTVWWTQTRPALHPQWDGQTEIWTQPIAPGTWTLQDHKTVIWRGYGMDAVWA
                     EGPHLYRVGDYLYLMTAEGGTSFEHSEMIMRTHAPRGFAAALAGFEKNLAAQDIWIEPA
                     RDGERSVVGRDDRLFEACKRNPILTHRHLGAGEPVQCVGHADLLLHPTVGWLLACLGVR
                     ETPGEEPGETFSYCGRETFVAPVVWQHNPVSWKLDGGEPNKRIDIVDPGWPVVAPGLGR
                     LPEKLVVDVDEDGLPCAVRGVDSARCDCAAGDNAACSAELIQLDDTRLVGVRGRDDYRF
                     LRVDGQEYAAFTRPEYTMMMHQDSTHVVMVMAEAESGQLTAEITDRGDKRCIALGALGA
                     NEWFGLRLHGNRLEFLAGQPAPDSIDEGTMPDIALIAHADVTYARIMADCDARFLSTEW
                     AGGFVGCLIGVKRR"
     gene            complement(5577..7196)
                     /locus_tag="APC1464_1424"
     CDS             complement(5577..7196)
                     /locus_tag="APC1464_1424"
                     /codon_start=1
                     /transl_table=11
                     /product="GH43_11|GH43"
                     /protein_id="PKD09796.1"
                     /translation="MKISNPVLPGFNADPSMIRVGDTYYIANSTFDWWPGVRLHESRDM
                     VHWNLLPGPLNRVSQLDMKGNPSGGGIWAPDLSYADGKFWLIYTDVKIVNGAFKDCANY
                     LVTAEDIRGPWSEPIRVNGVGFDASLFHDTDGRKYLVQQTWDFREYHHPFDGITLTEFD
                     VKTMQLKPETARTIWRGTDVKLVEGPHLYTINGWYYLFCAEGGTQYEHQESVARSRTLD
                     ELSFESMPSNPFISNFDTPGTYLQKQGHGALVDTPGGEWYYASLCGRPWRHENEPAHGV
                     RGWCTLGRETSIQKVEWDGDGWPYVVGGHGGERYVEAPADAIATEAPTDHSQHDEFESS
                     ELDLNWNTLRVPFTETMGRVGGGSLTLRGQGSLANLFELSLVGRRWQAFDFNAETKVTF
                     DPSNYMQMAGLTNFYNHLCWSWAFITWDEKRGQRVIEVAQNDFDTYTSFLKDTAIAIPD
                     DIESVWLRTKVRTRTYTYEYSFDGKTWHEIPVTLDAAVLSDDHVAQRYGGFFTGAFVGL
                     VAVDLSGYGKEAIFSHFDYMEI"
     gene            complement(7312..8208)
                     /locus_tag="APC1464_1425"
     CDS             complement(7312..8208)
                     /locus_tag="APC1464_1425"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72H66|3.A.1.1.25"
                     /protein_id="PKD09797.1"
                     /translation="MTTAVSPSVGKGKNKTYDPYALRKSAKTPWGNPVVYFFSLLLVAL
                     CVGPVLYIIIGGFRTNAQITRDPAGWPDPWNFENYKTVFTSNIFWPELVNSLIVSIGTM
                     VGIVVLALMVSFVIARYEFKFNKLLYSLFAAGMMFPITVAITPLYLLLRNLHLINSHLG
                     IILPQIAFGLPQAIIILVPFLKSIPKELEEAAELDGCSRIGFFGRMVLPLSWPGVATVG
                     ILSFVSSWNAYMLPLFLLNDSSKYTLPLGVQMFSSQHSVDTAQVLAFTSLSMIPALICF
                     TIFQKKIVGGLTGAVKG"
     gene            complement(8205..9257)
                     /locus_tag="APC1464_1426"
     CDS             complement(8205..9257)
                     /locus_tag="APC1464_1426"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72H67|3.A.1.1.25"
                     /protein_id="PKD09798.1"
                     /translation="MSVSAGARVQRRTSGLSDKARKRIEITILSLPALIMFLGFVILPV
                     FMAGYYGFFKWKGYGKPTVNGQFIGFENYKIILTDPNFQQALGHTLFVVVASLVIQGPL
                     AILFALLLNQRFKGRALIRTLIFVPYVVSEVIVGTGWGLILQTTGALNALLKKIGLGGA
                     DWISDPKIAIWTLMFIISWKYIGFAVILMIAGMQSIPEDLYEAAKVDGAGFWRQQWSIT
                     LPLLGPTIRIWAFMSIIGSLQLFDLVYIIWGQYVSSTAGTSTMATYMVREGRLANNYGY
                     GSAVAVVIFIISLVIALTYQRFVLNRDLEGALTDEKDAKRRAKRAAKEAAKLAKANGNA
                     AAVANEVVSQ"
     gene            complement(9351..10664)
                     /locus_tag="APC1464_1427"
     CDS             complement(9351..10664)
                     /locus_tag="APC1464_1427"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q9L027|3.A.1.1.21"
                     /protein_id="PKD09799.1"
                     /translation="MLVKNNKETTMKFKSVAAALLAAVTCVSMAACGSGSDTNADGKVE
                     ITMWHNSTTGDGKAYWESAAKAFEKENPNVTIKIEAIQNEDMDGKLQTALQDPNSAPDI
                     FMARGGQKLRDVVEAGQAMDLTDKISDTVKNQMATAEATGTIDGKIYSVQQSVLPGGIW
                     YSKDLFEKAGITETPKTWDEFKTVVQKLKDAGITPIAVGGKDAWPAAHWWYWFALRECS
                     ADTFDKAQSDKDFSDKCWTRTGDDVQALLDLDAFNDGFLTTPAQQGASSSAGLLANHMA
                     AMELMGGWEPGVIKDLTPDKKDMADLGYFAFPTMDGGEGDPTAIMGGSDGMAVGEWAPE
                     EAVDFLNFVSEKEWQEKYAEAFSTIPANKEAQDVVTNEALKQVLTVYNDASSVSMWLDT
                     VFGQNIGNALNEGVVNMMAGQGSAQDIVKGVEAAAAKG"
     gene            11003..12043
                     /locus_tag="APC1464_1428"
     CDS             11003..12043
                     /locus_tag="APC1464_1428"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|LacI,DBD-SUPERFAMILY|0036955"
                     /protein_id="PKD09595.1"
                     /translation="MASAEQRKSNGENKVKLADIAKQTGYSLATVSKALNGKADISEAA
                     RQAIDKALKDNGYIRRVSPSRKQRTIEVVFRDFETIWALEVLRGIITEAKPHNINVMVA
                     ESGDRQHPDSSWVEGIIDRQPIGAILVFSNLTDKERSMFQSHGIPFVVFDPSGNPALDD
                     LSVQADNWMGGVIATRHLLELGHKRIGIITGPDEMLCSRARLDGYSAALAERNIPTSPE
                     LITEGDFTTPGGYEGAMALLEDEQSRPTAIFAGNDLQAMGVYEAARQLKIRIPEDLSII
                     GFDDIQTAAYMGPALTTVRQPLQDMAATAARMVIDTNEGRKIQKRVVLSTSLVVRDSTR
                     RLKSRD"
     gene            complement(12052..13251)
                     /locus_tag="APC1464_1429"
     CDS             complement(12052..13251)
                     /locus_tag="APC1464_1429"
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-dependent butanol dehydrogenase 1"
                     /protein_id="PKD09800.1"
                     /translation="MRDFIFHNPVKIYFGKGQARHIAQEVERVEGAVLVVYGGGSIKRN
                     GAYDDVMAALAGTGRKIIELPGVTPNPRLDKALEGVRLVKEHGVGLILAVGGGSVIDCA
                     KFISLGSGIGDDEDLWDDYIETGKPAPEGLIPVGVVLTTAATGSEMGDAAVLTNWERNR
                     KLGYTSFPLMPRFSVLDPSYLMTLPAEQTVYGFEDMFCHTCEQYFSYPVDDNLSDEIAE
                     GIQRHILRSWRACLSDPKDYEARSNAMWDSTLALNRIISRGKEEDWVTHGIEHALSAYT
                     DIAHGAGLAVVHPHWMAYVYLVNDEVTARFARWAVDVWGVTPTGKTDRTVAEEGIDRYV
                     DFLRRVGAPLTLSEAGVPDDPASLDKYADHAGEAGGSFVQIHRDDARAILEACKEPVSF
                     "
     gene            complement(13608..14957)
                     /locus_tag="APC1464_1430"
     CDS             complement(13608..14957)
                     /locus_tag="APC1464_1430"
                     /codon_start=1
                     /transl_table=11
                     /product="xylose isomerase"
                     /protein_id="PKD09801.1"
                     /translation="MGLWDVDKIEYVGRAKGPKEDFAFHYYDADKVVAGKKMKDWLRFG
                     VAWWHTFNQELVDPFGTGTAHRPYYKYTDPMDQALAKVDYAFELFQKLGVEYFCFHDRD
                     IAPEGDTLRETNANLDKVVDKIDENMKSTGVKLLWNTSSLFTNPRFVSGAATSPFADIY
                     AYAGGQLKKSLEIGKRLGAENYVFWGGREGYENLWNTEMKRETDHIAKFFHMCADYAKE
                     IGFEAQFLIEPKPKEPTLHQYDFDAATAIEFLRNHDLTDVFKLNLEGNHANLAGHTYQH
                     EIRVARESGFLGSLDANQGDKLIGWDMDEFPTDLYETVAVMWEVLQAGSIGPHGGLNFD
                     AKPRRTSFYEEDLFRSHIAGMDAYAAGLLVADKMNQDGFIQNLQAERYSSYDSGIGKDI
                     DEGNVTLADLEAYSLDKPQSELIAATKSDHLESVKATINNYIIDALAEVE"
ORIGIN
        1 atggatgcaa ccacattgtc aataaccctc agcgcgatat tggccgtcat ctgcacacct
       61 tgcggcctgt ttctggggct tgttcccatg aaggccgacc tggtgaccgc caagcagtca
      121 aaggcctcgc agatggtgag cttcatcgtt gccatagtgt tcatcggctt gctggtcgca
      181 ggccatgatc tggagacctg ggccatggta atcggtctgg tcatcggctt cgccgttgcc
      241 aagatccccg cactgcacgc ctgggctttg cacaagtggc cgttcttcga acccaagaaa
      301 atggctccca cccccaagcg cgtcaagaaa gccaggaaga agtaagctct ggccttacct
      361 attcgctgaa agcgggatat cgacatcggt atcccgcttt ttcattggcc gcacatatcc
      421 gctgaggcac atcgccgaat catattgtcg aaatacaccc caagtcggta ggccgttgtc
      481 gagaacacgg cacccccgac acgaaagtgc ccatagcaca cccttcccca cttcgacctc
      541 ggtcaaaaga aaaagcccgg cgagcggccg ggcttaaaag gagaagagag gaagaagatt
      601 catcaaatca tgcttcgttg aatagagcca ggaatttggc gcgccacgca tagcgcgtcg
      661 agaccagcac cagaccaaca acggttagcg tgacgccaat cggcgcagcg gctggtgaaa
      721 cgaatagcag tacggcgtag gctgcggcca acaggcagag cgacagcagc agaacatgat
      781 gtgcgcgcat agcagtatct ccattgacgt tgcgtaggta tgcatggact tacagtattt
      841 agtttaatga tttaaccata tatcatattt gttaccaatg caaatcgaaa aggggccggc
      901 ctgccaaata ctggcagccc agccccactc agtgccacac aaaggccgag gcagaggcaa
      961 cagtcgaaac cgcgatcccg tcacttcgac cagatgagca cttccccatc gccatacgcc
     1021 gccaatgggc ctcgagccga gcatgcgccg cgcgcagcac cggtgatatc ccggtccaca
     1081 acaatcggcg aaccgtcagg attctcgaaa tactcctcga caatacgcgg ttggccaaga
     1141 tcagcagtgg agatcaccgg tccagttgcc gaccgaatcg attcgggcaa cgaaacggtc
     1201 atccatagct catcatcggt ttcgcgcaat gccaacgaag agccgtcacc actcaccacg
     1261 gcctcggctt cgccggaagc ggccttcgcg cccgaaacat aggcgttcga agacagcaat
     1321 accggctgct tcacgctgcg atacaactcc tcatcgccaa ggccagcctc ttcaatcagc
     1381 tgttcatact cctcaagcga gcgcggatag ccgtcaaaga acgcggttcc agcttccgcc
     1441 ataccggccg caccggcggc atccgcggta cacaacggtt tggcggaatc gtccacagcc
     1501 aagaacaggt tgttgacgta ccgatcatcg ccaccgtaga cgaatgcctc gccggccaca
     1561 tcggtgacgt gcgggaaatg gtatggcgtg gatcggtcca agacggcggt gtgacgaatg
     1621 cgaccggcga acagattgtt gacgaacgcc gcgccttgcg cataatcgtc gaaactgaac
     1681 tcggaggcaa acacgttgtt cataaacgta atcggcccgt gggtcacctc ggtcatcaca
     1741 tctcgcgtgt tgcggtagaa cacgttcgaa tccaccacgg tgccctgcgc ctgccagtcg
     1801 agccacatac ccagcaccga atcatgcacc cggttgccgc gcaccaccgt gtcgacggct
     1861 gcgtgcattt taatggcggc cacttcccag ccgaagaact cgcgcttggc gccgatgcgg
     1921 tatatgtggt tgccttcaat cagcgagaag gcgcagccca tatgaccaac cacaccattc
     1981 tggccgcagt cgtagattac gttgccgcgc accacgtgcc cgccgactac gcctttctcc
     2041 cagccggcat gcagcgcctt gtagacggcc tctttttggt attggtaccc ggacttacga
     2101 tgggtgcgcg tcgattcgtt gtcgccggtg gaaatctcct tgcccagcga gatcgccgaa
     2161 catttcgcgt catgaatgcg attgttttcg ataacccacc cgcgggacca atgcgggccc
     2221 accagcccga cctgatcggc agtcggcggc gtgtaagggc aggccgcctg cgccatttca
     2281 aagccggaga ccgtaatgta attgacgaac gggcggctcg ggtagaaaca ggtctcgcgc
     2341 acgttgattt cggtaagttc cgcattcggg tcggcttcat ggaaattggc ccaaatggtt
     2401 gtggcctcat catcgaccgc acagcaccac acgttcacgg tggcatccgg attaatcagc
     2461 ggcacgatgg aatcggtggc ggcgtcacgg ccggtatccc aacgctgtgg gttgcgcacc
     2521 ttgtccagcg aggcgacttc gtagaaggat ttgccattca gatacacatc gcccaggtgg
     2581 cgtacctcga cctttgggtc cgggtatacg gtccaatcgc cgaatacggt ttccacgtac
     2641 gggttgtatc cgttgaagaa tgcgttcggg attacggctt tccacacgcc atcgccttcg
     2701 ggctgccatg tgtcgatacg ttcggagccg gtgattaccg ggcgcggttc gcccgcggcc
     2761 gcgcggtaga cgatgcggtt cgtggcgctc tctccgccga atcgggggtc gacagattcc
     2821 cgataggtgc cggcatgcac aaccacctca tcgccggctc gggcgatggc cgccgcttgg
     2881 ccgatggtca gaaacgggtc ggccgcgctg ccggcgccgt tcgtcttcgc cgcctgcgcg
     2941 gaaacatgat attgcgtcat tgcattgttc ctttctctcc tgtatcccgg tttcgccgtg
     3001 acagttggcc agagcagcaa acctaccgac cctcggcagc ggcccgctct tcaggagtcc
     3061 agtcatccgg gacttcggca atcacatggc acggattgcc cacagcgatg gaatcggcgg
     3121 gaatgtcgtg ggtgacgact gcgcccgcac cgataatcga gttgtctccg atggtgacgc
     3181 cggggcagat caccacattg ccgcccagcc acacattgtt gccgatggtc acgtcggcgt
     3241 tgtgctgcca gccttccagt cgaggcttgc gggcgatggc gtggtttggc gtatagatgc
     3301 tcacgcgcgg gccgatcagg caatcggagc cgatggagat cgggccgccg cccacaatca
     3361 gcaggtccat gttgatgaac gtacggtctc cgattttcag gcccagcccg taatcaagcc
     3421 ggattggcgg gcggaagtcc acgccctcgc cggcctcggg cacgagttcg cggaacagtc
     3481 gctcagcttc ggcggtgtct tcaaagtaga tgcgattgat gcggtcgcac gtggactgcg
     3541 cctcgcgcgt aagttccggc aaaatctccg acttacggta ctgcaaccag tcatcggcga
     3601 acagtttcgc cacatccggg tgatcttgct tgagttgttc gagatcgtgc gccatcgatt
     3661 gcccccttgc atttgtttaa cgattaaaca atatgattgt acaatattgt agagcgggct
     3721 gagaccatta ccgccgtttt acgccgatca ggcaacccac gaatccgccg gcccattcgg
     3781 tactgaggaa tcgcgcatca caatctgcca tgatacgagc ataagtaacg tccgcgtgcg
     3841 caattagtgc aatatcaggc attgttccct catcaatgct gtcaggtgca ggctgcccgg
     3901 caaggaattc caaacgattg ccatgcaagc gcaatccgaa ccattcgttg gccccaagcg
     3961 ctccaagcgc aatgcaccgc ttatctcccc tatcggtgat ttcggccgtc aattggccgg
     4021 attccgcttc cgccatgacc atgacaacat gggtggaatc ctgatgcatc atcatcgtgt
     4081 attcgggccg ggtgaacgcg gcatattcct gcccgtcgac gcgcaggaac cggtaatcgt
     4141 cacggcctcg aacgccgact aggcgggtat cgtcgagctg gatgagctca gcagagcatg
     4201 cggcattatc accagcagcg caatcacacc tcgcagagtc cacacccctc actgcacatg
     4261 gcaatccatc ctcgtcaacg tccacgacca acttctcggg aagccggcca agccccggag
     4321 ccacgacagg ccaaccggga tcgacgatat cgatacgctt attcggctcc ccaccgtcca
     4381 gcttccacga gaccggattg tgctgccata cgaccggtgc cacgaacgtt tcccggccac
     4441 agtagctgaa cgtttctccg ggttcctcgc ccggagtctc gcgtacgcca agacacgcga
     4501 gcagccagcc gacggtcgga tgcagcagca gatcggcgtg cccaacgcat tggactggct
     4561 cccccgctcc caaatgacgg tgtgtgagga tcggattgcg tttgcaagcc tcaaacagcc
     4621 ggtcatcgcg gcccaccacg cttcgttcac cgtcacgcgc cggctcaatc cagatatctt
     4681 gcgcagcaag gttcttctca aaaccggcga gcgccgccgc gaatccgcgc ggtgcgtgcg
     4741 tgcgcattat catctcactg tgctcgaagc tggtgccgcc ctcggcggtc atcaggtaga
     4801 ggtaatcgcc cacccggtac aaatgcggcc cttcagccca taccgcatcc atgccatagc
     4861 cgcgccaaat cacggtttta tggtcttgca acgtccacgt gcctggggcg atgggctgcg
     4921 tccagatttc ggtttgacca tcccactgcg ggtgtaatgc cgggcgcgtt tgcgtccacc
     4981 acactgtgcc atcgccgtct tcaaagatgt ccggatcaat gccttcggcc ccggccaccc
     5041 agtacgggcc gcgccatggt ccggtcaact catcggcctc gatgacgaaa ttgccttggg
     5101 cgtcacggca gttatcaata tccttctgcg agcatcccgc agcgagcgcc ttcacctcat
     5161 ccacgcgggc cacggtgcat acgatcacat atcgcccgcc gatacggcga atggtcggcg
     5221 cgtacaggcc gccggaatcc tcgacgccat caatgagcag ccgatgagac atcgtctcat
     5281 ccaccgcatt cgccgtgcgc gtccacgtca caagatcacg ggtcgtatga atgggcaacc
     5341 ccggcaccaa ttcaaacgag gagttgacca gcacgatttc ctcgcgcgtc gtatcccata
     5401 tccaggacgg gtccgggtac atgccacgca acaccgggtt ggagacggtt atggtacatt
     5461 cgcggccacg gtcgccgcaa tgttcattgt cgcttgccac aagtgtcgcc tttcattccc
     5521 cagtgccgaa tagtcaggcg actttccctg attatcagga aagccgcctg gcgtcatcat
     5581 atttccatgt aatcgaaatg gctgaaaatg gcttctttgc cgtatccgga aaggtccacg
     5641 gccaccaacc cgacgaacgc gccggtaaag aatccgccat aacgttgggc cacatgatca
     5701 tcggagagca cggcggcgtc cagcgtcacc ggaatctcat gccatgtctt gccatcgaac
     5761 gaatactcgt aggtgtaggt acgagtacgc actttggttc gcaaccatac ggattcgatg
     5821 tcatcaggaa tggcgatggc tgtgtctttg aggaacgacg tgtacgtatc gaaatcgttc
     5881 tgggcgactt cgattacgcg ctgccctcgc ttctcgtccc aggtgatgaa tgcccatgac
     5941 cagcacaggt ggttgtagaa gttggtcagg ccggccatct gcatgtagtt gcttggatcg
     6001 aatgtcacct tggtttcggc gttgaaatcg aacgcctgcc aacggcgtcc taccagcgac
     6061 agttcaaaca ggtttgccag cgacccttga ccacgcaagg tcagcgagcc gccgcccacg
     6121 cggcccatgg tctcggtgaa tggcacacgc agggtgttcc agttgaggtc gagttcgctc
     6181 gattcgaact cgtcatgctg gctatgatcc gtaggggcct cagttgcgat ggcgtcggcc
     6241 ggggcttcga cataacgctc tcccccatgg ccgccgacca catacggcca gccatcgcca
     6301 tcccactcga ccttctgaat cgaagtctct cggccgagcg tgcaccagcc gcgcacgcca
     6361 tgagccggct cgttctcgtg ccgccagggc ctgccgcaca gtgaagcgta ataccattcg
     6421 ccgccgggcg tatccacgag tgctccatgc ccctgctttt gcaggtaggt gccgggggta
     6481 tcgaagttgg agatgaacgg attgctcggc atgctttcga acgaaagctc atccaaggtt
     6541 cgcgaacggg ccacggactc ctgatgctcg tattgggtgc cgccttccgc acaaaacagg
     6601 tagtaccagc cattgatggt gtagaggtgc ggcccttcga ctaatttcac atcggtgccg
     6661 cgccagatgg tgcgggctgt ttccggcttc aattgcatgg tcttgacatc gaattcagtc
     6721 aaggtgatgc cgtcgaacgg atgatgatat tcacggaagt cccaggtttg ctgcaccaga
     6781 tacttgcgtc catcggtatc atggaacagg ctggcgtcga agcccacgcc attgacacgg
     6841 attggctcgc tccacgggcc gcggatgtcc tcggcagtga ccagatagtt cgcgcaatcc
     6901 ttgaacgcgc cgttgacgat cttcacatcc gtgtagatga gccagaattt gccgtccgcg
     6961 taggacaggt caggcgccca gatgccgccg ccagacgggt tgcccttcat gtccaactgg
     7021 gaaacgcggt ttaagggccc gggcagcaga ttccagtgaa ccatgtcgcg ggattcgtgc
     7081 aaacggactc ccggccacca gtcaaatgtg gaattggcga tgtagtaggt gtcgccgacg
     7141 cgaatcatcg agggatctgc gttgaatccg gggagtacgg gattggagat cttcatggtt
     7201 ttctcctcat tgaaaagaat gggtgccgtg ggaaggagga aaggaagagg ttgaaaggaa
     7261 tcggcccaaa gagccatgta cctttccacg gcacgtttat ggttgctgcg actagccctt
     7321 gacagcaccg gtcaggccgc caacgatctt cttctggaaa atggtgaagc agatcagcgc
     7381 ggggatcatc gacagcgagg tgaaggccag tacctgagcg gtatcgaccg aatgctggga
     7441 gctgaacatc tgcacgccga gcggcaaggt gtacttgctg gaatcgttga gcaggaacag
     7501 cggcagcatg taggcgttcc agctgctcac gaagctcagg atgccgacgg tggccacgcc
     7561 gggccagctc aacggcagca ccatacggcc gaagaagccg atgcgagaac agccgtccag
     7621 ctctgccgct tcttccagtt ccttaggaat ggacttgagg aatggcacca ggatgatgat
     7681 ggcctgtggc aggccgaatg ctatctgggg cagaataatg cccagatgcg agttgatcag
     7741 gtgcagattg cgcagcagca gatacaacgg ggtgatggcc acggtgatgg ggaacatcat
     7801 gccggcggcg aacagcgagt acagcagttt gttgaatttg aactcgtatc gggcaatgac
     7861 gaagctcacc atcaaggcca gcaccacgat gcccaccatt gtgccaatgg agacgatcag
     7921 ggagttgacg agttccggcc agaagatgtt cgaagtgaac accgtcttgt aattctcaaa
     7981 gttccatgga tcgggccagc cggccgggtc cctcgtaatc tgcgcattgg tgcggaagcc
     8041 gccgataatg atgtacagca ccgggccaac gcacagcgcc acaagcagca gtgagaagaa
     8101 gtagacgacc gggttgcccc acggggtctt tgcggatttt ctcaatgcat acggatcata
     8161 ggtcttgttc ttgcccttgc ccacggacgg ggagactgcg gtcgtcattg tgaaaccacc
     8221 tcatttgcaa ctgctgcggc attgccattg gccttggcaa gcttggccgc ttccttcgcc
     8281 gcacgcttgg cacgacgctt ggcatccttc tcgtcggtga gcgcaccttc gagatctcgg
     8341 ttaagtacga accgctggta ggtcaaggca atgaccagcg agatgatgaa gatcaccacg
     8401 gccacggcgg aaccgtaacc atagttgttg gcgagtcgac cttcgcgcac catgtaggtt
     8461 gccatggtgg acgttcctgc ggtagacgac acgtactggc cccagatgat gtagaccaag
     8521 tcgaacagct ggagagaacc gataatcgac atgaatgccc agatacgaat ggtggggccg
     8581 agcagtggca gggtgatgct ccactgctga cgccagaatc cagcaccatc cactttcgcg
     8641 gcttcataga ggtcttcggg aatcgactgc atgccggcaa tcatcaggat gacggcgaag
     8701 ccgatgtact tccacgaaat gatgaacatc aatgtccaga tggcgatttt cggatcggag
     8761 atccagtccg ccccgccaag tcctattttc ttgagtagcg cattcaatgc gcctgtggtc
     8821 tggaggatga ggccccagcc ggtgccaacg atgacttcgg aaacgacgta cggcacgaaa
     8881 atcagggtac gaatcagtgc gcggcccttg aatctctggt tgagcagcag ggcgaagagg
     8941 atggccagcg gcccctggat gacgagcgaa gcgacgacca cgaatagcgt gtgccccaat
     9001 gcctgctgga agttcgggtc ggtcagaatg atcttgtagt tttcaaaacc gatgaactgg
     9061 ccgttgacgg tgggcttgcc atagcccttc cacttgaaga atccgtagta gccggccatg
     9121 aacaccggca ggatgacgaa tccgaggaac atgatcaggg caggaagcga aaggatggtg
     9181 atttcgatac gtttgcgagc cttgtcgctt aagcccgacg tgcggcgctg taccctcgcg
     9241 cctgctgaaa ctgacattgt tgaggccttc ctaagaaaac aaattgggcc gcggttgttg
     9301 ctgtgcaagc attcgccgca gcccgggaat tacggtcggg tcagagcgaa tcagcccttg
     9361 gccgcagcgg cttcaacacc cttgacgatg tcttgggcgg aaccttgacc ggccatcatg
     9421 ttgaccacgc cttcgttgag tgcgttgccg atgttctgac cgaacacggt gtcgagccac
     9481 atggacacgg aggatgcgtc gttgtagacg gtcagcacct gcttcagagc ctcgttggtc
     9541 accacatcct gggcttcctt gttggccggg atggtggaga acgcctcagc gtacttctcc
     9601 tgccattcct tctcggagac gaagttgagg aagtccacag cctcttcagg cgcccactcg
     9661 cccacggcca tgccatcgga accacccatg atggcagttg gatcgccttc gccaccgtcc
     9721 atggtcggga atgcgaagta gccgaggtcg gccatgtcct tcttgtccgg agtcaggtcc
     9781 ttgatcacgc cgggctccca tccgcccatg agttccatag ctgccatgtg gttggcgagc
     9841 aggccggcgg aggagcttgc gccctgctgg gccggagtgg tcaggaagcc atcgttgaag
     9901 gcatcgaggt cgagcagcgc ctgcacatca tcaccggtac gggtccagca cttatcgctg
     9961 aagtccttat cggactgggc cttgtcgaag gtgtcagcag agcattcgcg cagtgcgaac
    10021 cagtaccacc agtgggcggc cggccaggcg tccttaccgc ctacggcaat cggcgtgatg
    10081 ccggcgtcct tcagcttctg caccacggtc ttgaactcat cccaggtctt cggagtttca
    10141 gtaataccgg ccttctcgaa cagatccttg gaataccaga tgccgccggg aagcactgac
    10201 tgctgcacgc tgtagatctt gccatcgatg gtgccggtgg cttcagcagt ggccatctgg
    10261 ttcttgacgg tgtcggagat cttgtcggtc aggtccatgg cttgcccagc ttcgaccaca
    10321 tcacgtagct tctggccacc acgcgccata aagatatcgg gggcggaatt cgggtcctgc
    10381 agagcggtct gcagcttgcc gtccatatcc tcgttctgaa tggcttcgat cttgatggta
    10441 acgttcgggt tttccttctc gaacgccttg gcggcggatt cccagtatgc cttgccgtcg
    10501 ccagtggtgg agttgtgcca catggtgatt tccaccttgc catcggcgtt cgtgtcgctg
    10561 ccgctcccgc aagcggccat gctgacacag gttaccgccg ccagaagtgc ggcggccacg
    10621 gacttgaact tcattgtcgt ctccttattg ttcttgacca gcatgaaacc gatccgcgat
    10681 ttacgaaagt ttcgaaagat atatcagcca gttacatatc taacagctgg taattaatga
    10741 tgttttcagt gaaacttcgc cgtttcacct accccatcag ccttcttcaa ctttaccgaa
    10801 aactcgcttt atgttttcga tacctttatc ataaagagcc ttagtttgac ggtcaaacga
    10861 aatttatatc ggctttttta ctatcaaaat cgttgaaatt ccaacctttt ttatctatac
    10921 ataccattct ttatcgtcaa attaacttta cgaaagtttc gaatatactg ataccaacat
    10981 tctctgatga aggcggtcaa tgatggcgtc ggcagaacag cgcaaaagca acggcgagaa
    11041 caaggtcaaa cttgcagaca tcgccaaaca gactggctac tcactggcca ccgtgtccaa
    11101 agccctgaac ggcaaggcgg atatttcgga ggcggcccgg caggccattg acaaagccct
    11161 gaaagacaac ggctacattc gccgcgtctc cccctcccgt aaacaacgca ccatcgaggt
    11221 ggtatttcgg gattttgaga ccatttgggc gctggaggtg ctcaggggca tcatcacgga
    11281 ggccaagccg cacaacatca atgtcatggt tgcggaaagt ggcgaccggc agcaccccga
    11341 ctcttcctgg gttgaaggca tcatcgaccg ccagcccatt ggcgctattc tggtgttctc
    11401 caacttgacg gacaaggaac gcagcatgtt ccaatcacac ggcattcctt tcgtcgtctt
    11461 cgacccttcc ggcaatccgg cattagatga tctctccgta caggcggaca actggatggg
    11521 cggcgtcatc gccacccgtc atctgctgga actcggccac aagcgcatcg gcatcatcac
    11581 cggaccggat gaaatgctct gctcacgtgc ccggcttgac ggctattcgg cggccctcgc
    11641 cgaacgcaat atccccacct cccccgaact catcaccgaa ggcgatttca ccacgccagg
    11701 cggttacgaa ggagccatgg cgttacttga agacgaacaa agtcgcccga ccgccatctt
    11761 tgcaggcaat gacctacagg ccatgggcgt ttacgaggcg gcccgtcaac tgaaaatccg
    11821 tatccccgaa gatctgtcca ttatcggatt cgacgatata cagaccgccg cgtacatggg
    11881 cccggcgttg accacggtcc gccagccatt gcaagacatg gccgccactg cagcccgcat
    11941 ggtcatcgat accaatgaag gacgcaagat tcagaagcgc gtggttcttt ctacgtcttt
    12001 ggtggtgcgg gacagcacgc ggcggctcaa atcacgggat tagtccaacc gtcagaacga
    12061 caccggttcc ttgcatgcct cgagaatcgc tcgggcatcg tcacggtgaa tctgcacgaa
    12121 tgagccgccg gcctcaccgg catgatcggc gtacttgtcg agagaggcgg gatcgtcggg
    12181 cacgccggcc tcagaaagag tcagcggcgc acctacgcga cgcaggaaat cgacatagcg
    12241 atcaatgcct tcctcggcca ccgtgcgatc ggttttgccg gtgggcgtca caccccacac
    12301 gtcgaccgcc cagcgggcaa agcgagccgt cacctcatcg ttgaccaaat acacgtatgc
    12361 catccaatgc gggtggacca cagccagacc agcaccgtga gcgatatcgg tgtatgcgga
    12421 cagcgcgtgc tcgatgccgt gcgtcaccca atcctcttcc ttgccgcgcg agataatgcg
    12481 gttcagagcc aacgtggaat cccacattgc attggagcga gcctcataat ctttcggatc
    12541 ggacaagcac gctcgccacg aacgcagaat atgacgttgg attccctcgg cgatttcgtc
    12601 ggaaaggttg tcgtccaccg gataggagaa atactgctca cacgtgtggc agaacatgtc
    12661 ctcgaagcca tacaccgtct gttcggcggg caatgtcatc aggtagcttg gatccagcac
    12721 ggagaacctg ggcatcagcg ggaacgacgt atagccgagc ttgcggttac gttcccaatt
    12781 ggtgagcacg gccgcatctc ccatttccga gcccgttgcc gcggtggtga gcaccacgcc
    12841 aaccggaatc agcccttcag gtgccggttt gccggtttcg atgtagtcat cccacaaatc
    12901 ctcatcgtca ccgatgccgg aacccaacga aataaatttc gcgcagtcga ttaccgagcc
    12961 accgccaacg gccagaatca ggccgacgcc atgctccttg accagtcgta cgccttccag
    13021 cgctttgtcc aatcgcgggt tcggcgtaac gccgggcagc tcgatgattt tgcgcccggt
    13081 tcctgccagc gcagccatca catcgtcata ggcaccgttg cgtttaatcg atccgccgcc
    13141 atacaccacc agaacggcgc cctcgacacg ctccacctcc tgtgcgatat ggcgcgcctg
    13201 ccctttgccg aagtagatct tcaccgggtt atggaaaatg aaatctcgca tgcgtaactc
    13261 ctttgttgtg ctgatgttcc cctgagaaca gcttatcttc tcctgccgcc gatatgttca
    13321 ccgtcgccaa cacgtcaccg tcaacgcacc cctccgcgaa catgttcgcc cccaccccaa
    13381 tccacccccc agccccgcca caaccagaaa accgcccttg gcgacgttgc ctcaggcggt
    13441 tttccagcgg aaggagagaa aggagaaaga aggaatggaa aggtgccatg cgggcataac
    13501 acaacaccgc acatggcgaa actatcgaat cagcccatcg ggcgcactgg catcataatt
    13561 gatgtgtaca cgcccgatgg agcgaattca atcggtcaga ccgatggtca ctcgacctca
    13621 gccagggcat caatgatgta gttgttgatg gtggccttga cagactcgag gtgatcggac
    13681 ttggtggcgg cgatgagctc ggactgcggc ttgtcgaggc tgtaggcttc gaggtcggcc
    13741 aaggtgacgt tgccctcgtc gatgtccttg ccgatgccgg agtcgtagga gctgtagcgc
    13801 tcggcctgaa gattctggat gaagccgtcc tggttcatct tgtcggcaac cagcaggccg
    13861 gcggcgtagg catccatgcc ggcgatgtgg gagcggaaca ggtcctcctc gtagaaggag
    13921 gtacggcgcg gcttggcgtc gaagttcaga ccaccgtgag gtccgatgga gccggcctgc
    13981 aggacttccc acatgacggc gacggtctcg tacagatcgg tcgggaactc gtccatatcc
    14041 cagccgatga gcttgtcgcc ctggttggcg tcgagggaac cgaggaagcc ggactcgcgg
    14101 gccacgcgga tctcgtgctg gtaggtgtgg ccggccaggt tggcgtggtt gccttccaag
    14161 ttcagcttga agacgtcggt caggtcgtgg ttgcgcagga actcgatggc ggtggcggca
    14221 tcgaagtcgt actggtgcag cgtcggctcc ttcggcttcg gctcgatcag gaactgggcc
    14281 tcaaagccga tttccttggc gtaatctgcg cacatgtgga agaacttggc gatgtggtcg
    14341 gtctcgcgct tcatctcggt gttccacagg ttctcgtagc cttcgcggcc accccagaac
    14401 acgtagttct cggcgcccag gcgcttgccg atctccaagc tcttcttgag ctggccaccg
    14461 gcgtaggcgt agatgtcggc gaacggagaa gtggcggcgc cggacacgaa gcgcgggttg
    14521 gtgaacaggg aggaggtgtt ccacagcagc ttgacaccgg tggacttcat attctcgtcg
    14581 atcttgtcaa cgaccttgtc gaggttggcg ttggtctcgc gcagggtgtc gccttcgggg
    14641 gcgatgtcac gatcgtggaa gcagaagtac tcgacgccca gcttctggaa cagctcgaag
    14701 gcgtagtcga ccttggccag agcctggtcc atcggatcgg tgtacttgta gtacgggcgg
    14761 tgcgcggtgc cggtgccgaa cggatcaacc agttcctggt tgaaggtgtg ccaccaagca
    14821 acgccgaagc gcagccaatc cttcatcttc ttgccggcaa cgaccttgtc ggcatcgtag
    14881 taatggaagg cgaagtcttc cttcggtcct ttggcgcggc cgacgtactc gatcttgtca
    14941 acatcccaca gacccat
//
