LOCUS       CP001515               12625 bp    DNA     linear   BCT 30-JAN-2014
DEFINITION  Bifidobacterium animalis subsp. lactis Bl-04, complete genome.
ACCESSION   CP001515
VERSION     CP001515.1
DBLINK      BioProject: PRJNA32897
            BioSample: SAMN02603172
KEYWORDS    .
SOURCE      Bifidobacterium animalis subsp. lactis Bl-04
  ORGANISM  Bifidobacterium animalis subsp. lactis Bl-04
            Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
            Bifidobacterium.
REFERENCE   1  (bases 1 to 12625)
  AUTHORS   Barrangou,R., Briczinski,E.P., Traeger,L.L., Loquasto,J.R.,
            Richards,M., Horvath,P., Coute-Monvoisin,A.C., Leyer,G.,
            Rendulic,S., Steele,J.L., Broadbent,J.R., Oberg,T., Dudley,E.G.,
            Schuster,S., Romero,D.A. and Roberts,R.F.
  TITLE     Comparison of the complete genome sequences of Bifidobacterium
            animalis subsp. lactis DSM 10140 and Bl-04
  JOURNAL   J. Bacteriol. 191 (13), 4144-4151 (2009)
   PUBMED   19376856
REFERENCE   2  (bases 1 to 12625)
  AUTHORS   Barrangou,R., Briczinski,E.P., Traeger,L.L., Loquasto,J.R.,
            Richards,M., Horvath,P., Coute-Monvoisin,A.-C., Leyer,G.,
            Rendulic,S., Steele,J.L., Broadbent,J.R., Oberg,T., Dudley,E.G.,
            Schuster,S., Romero,D.A. and Roberts,R.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAR-2009) Danisco USA Inc, 3329 Agriculture Drive,
            Madison, WI 53716, USA
COMMENT     Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
FEATURES             Location/Qualifiers
     source          1..12625
                     /organism="Bifidobacterium animalis subsp. lactis Bl-04"
                     /mol_type="genomic DNA"
                     /strain="Bl-04; ATCC SD5219"
                     /sub_species="lactis"
                     /culture_collection="ATCC:SD5219"
                     /db_xref="taxon:580050"
     gene            1..1605
                     /locus_tag="Balac_1566"
     CDS             1..1605
                     /locus_tag="Balac_1566"
                     /note="COG0366 Glycosidases"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q07837|8.A.9.1.2"
                     /protein_id="ACS46907.1"
                     /translation="MSSSHQVPQWLDQATFYEIYPQSFADSNADGIGDIPGIIEHLDYL
                     LQLGCNAIWLNPLYESPFRDAGYDISDYKKVAARYGTNDDLAALFAAAHARGMHVLLDL
                     VPGHTSNEHPWFRQSATDSPNLYDDRYIWTGNWIEGGDGLPFIGGEEARDGAYIVNFFA
                     FQPALNYGFAHPRKGWQAPALGDEALRTCDAMLDVMRFWLDMGADGFRVDMADSLVKGD
                     DEGKPYTIRTWQYMLGQIRGEYPEAAFVSEWGRPDEAFEAGFDMDFYLDWRWDGVANGY
                     SMLLRDTDTPMLRDGDHSYFNADSGTSIVPFLGEYEPRLEAARKAHAYFDLITCNHDTM
                     RLVPRLTTRELALAYSTIFLMPGVPFIYYGDEIGMRYRNLPGKEGGYTRTGSRTPMQWD
                     NSANHGFSQAAADALYLPVDEREDAPTVAAAVADGNSLWHHMHAALEQRRSTPAFAPDA
                     DFSVLFAEEGRRPFVFKRAKDGVSAIVAVNPGRDGETVTLPDDDGSETRTITLNIGGAV
                     LDGTTLTLPPQSFAVLQ"
     gene            2051..4249
                     /locus_tag="Balac_1567"
     CDS             2051..4249
                     /locus_tag="Balac_1567"
                     /note="COG1640 4-alpha-glucanotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="GH77"
                     /protein_id="ACS46908.1"
                     /translation="MSQINSAPPRREESPERLARPLIQLAKGCGVATCYIDQLGTYVEI
                     RDAVLISVLGALGVDASTPELVDINLNARRNEAHERLVAPTVVKFLGTPASTPLHTKHG
                     EPHIGLTLEDGSDATDALSLTFREHDGDVDVYDLAIGDNLEIGYHTLHVRDGETGSERD
                     VDVTLLCAPASIPVPEALASHKRWGWMTQMYSVRSPESWGVGDYGDLRELLVDAAGSGA
                     DFMLINPVHASAPVSPIEPSPYSPMSRRFINTTYIRPQDIAEFAELDEQDAAAVRALHE
                     QVAPMNTESSPMDLDAAWKAKRAALQIIFRQPRSPERQASFEAFKEKAGADLDTWALWS
                     VAFEVLGEPWEPDSWFRMTAKSNPRIQALRTEHPDLYEFACWLQWIAEEQLDAAQRAAR
                     DAGMSLGLMQDMAVGVHSYGADAWGNPERFAVGSVTVGCPPDFYNQQGQDWGQPPLNPN
                     YLELTGYRMYREMVHHMFEHAGAIRIDHILGLFRLWWIPAGQGAKGGAYVTYNYDAMIA
                     VLSIEATRVNGIVIGEDLGTVPDFVRNVLARHGLLGTTVEWFARVDDSPNAGDPYAMPQ
                     TYRTYSLSSVTTHDLPPTAGYLMLEQVKLREELGLLTEPVEEFRESALAERQAMLDLLV
                     QGGWMSQEAADDVPDNLQTIVEAMHAMLTDAPSLLLQAALVDGVGEARAQNQPGTSTQY
                     PNWRIPLADEHLKVVPTQEVFKSPRVQALAKIMNRINQ"
     gene            complement(4721..5323)
                     /locus_tag="Balac_1568"
     CDS             complement(4721..5323)
                     /locus_tag="Balac_1568"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|E4R229|9.B.28.1.3"
                     /protein_id="ACS46909.1"
                     /translation="MKFLSPDSRFMQGWNDLTDAIWINMLMLVTSLPVVTAGAALCAGS
                     TALRKSQRGQGTVTRNYFAAFRENLAKATLLWLIFGICGAAIAYSWIVLQITPLLIPKF
                     ALTIIWAIGFEWAFYLQARFENPLGQTLRNAYVFGVVYFPATLACVAIDVVFVGLLVAA
                     WFYMPQGLFLLVVLGYGCMLALHVPILEYALRRYTRQ"
     gene            complement(5642..6478)
                     /locus_tag="Balac_1569"
     CDS             complement(5642..6478)
                     /locus_tag="Balac_1569"
                     /note="COG0395 ABC-type sugar transport system, permease
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8NMV5|3.A.1.1.45"
                     /protein_id="ACS46910.1"
                     /translation="MQEKPKHGALWTIFFSMISIAWVFPIFLVLLNSFKGKAYISRNAF
                     AFPVGDTFVGLENYKRGIESTNFFASFGWTVLITVGSVCLILVCTSMCAWWIVRVNNWA
                     AKLLYTLFLFNMIVPFQMVMFTLSKLADMLKLNTPWGLCFIYLGFGAGLAVFIFTGVVK
                     GIPQSLEESAMIDGASVPRIFFQVVVPIMKPSIVSVAILEAMWVWNDYLLPYLTLDLGK
                     YKTISVAVQYLKGGYGSVDMGAMMACLVLAIIPIIVFYLICQKYIVKGVMAGAVKG"
     gene            complement(6478..7332)
                     /locus_tag="Balac_1570"
     CDS             complement(6478..7332)
                     /locus_tag="Balac_1570"
                     /note="COG1175 ABC-type sugar transport systems, permease
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8NMV4|3.A.1.1.45"
                     /protein_id="ACS46911.1"
                     /translation="MISMAGKAIRRWWALFVLPTFVAFFIGFLVPFIYGIYLSFCSFTT
                     VTDAKFIGWQNYARAIKDKEFLHALGFSTLMTIVTTIVINVVAFAIAYLLTKSIRGSNL
                     FRSVFFMPNLIGGIILGYIWMLLLNGVLAHWERSLTYSAKYGFWGLVILVCWQQIGYMM
                     IIYIAGMQSLPTDVLEAAEVDGANGRQVMFRIIIPLMMPSITVCSFLTVTNGFKLYDQN
                     LALTNGAPQNMSEGLALNITRTFYGRIGWEGVGQAKAVLFFILVAIVALIQNKITTSKE
                     VDA"
     gene            7795..8805
                     /locus_tag="Balac_1571"
     CDS             7795..8805
                     /locus_tag="Balac_1571"
                     /note="COG1609 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|LacI,DBD-SUPERFAMILY|0036955"
                     /protein_id="ACS46912.1"
                     /translation="MNASIQDVAKAAHVSISTVSRSFTRPELVSAATREKVLRIAEELN
                     FSTSRSAAALKTGRAMRVALLMSDHIRLWFSASVIEGLNSVLHAEGYDISIFQISSIEE
                     RRDFFEMLPVRRNADAVIVASFDADETEIAQLASANVPIIGINSVMPRELGFTAAVNID
                     DTQGSILAARHLINLGHRDIAYVRTNRDVSLHFSVQQRFDSFMECCAGSGISPTVIVAQ
                     EGPDRIRRVLTDLMSLERMPTAIACQEDGIAVPLIFQLERSGYEVPNDISVIGYDNSFY
                     ANDIGLTTIAQDPIEMAKMAAEMTVKLIEGEKPEHLFRTIPAELVVRSSTAKHVA"
     gene            complement(9157..10491)
                     /locus_tag="Balac_1572"
     CDS             complement(9157..10491)
                     /locus_tag="Balac_1572"
                     /note="COG1653 ABC-type sugar transport system, periplasmic
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8NMV3|3.A.1.1.45"
                     /protein_id="ACS46913.1"
                     /translation="MNRTVKATVGLVAIAAMSLTGLAACGGSSADDGKGKVYFLNFKPE
                     TADQWVALAKKYTDKTGVQVKVQTAASGTYQQTLKSELAKSDAPTIFQVNGQVDYQNWK
                     GYTADLKDTGIYNELNNKDSALKDGDKVVGVPYVVEYYGIIYNKDLLKKYTELPGAKIK
                     DAKEINSFDKLKEVSDDMQAKKDQLGIKGAFTSAGFDSSSDWRFKAHLANIPLSYEFKE
                     DGVTTQPETIKGTYLPNFKNIFDLYLKDSTTAPSQLSSKTGNDANSEFALGEAAFYQNG
                     TWAWADLQKAGMKPDQVGMLPIYIGAKGEENQGLATASSENCLCVNAKASEADQKASKD
                     FLNWVVTSDEGIKALSEDMGFTTPFKTFDKVKSDNPLVEEAVEDSKSGKQQVAGNFTMM
                     PSEEWQNQLGQAMLAYAQGTGSWDDVRKAFVDNWKTEYDNAHANQ"
     gene            10850..12625
                     /locus_tag="Balac_1573"
     CDS             10850..12625
                     /locus_tag="Balac_1573"
                     /note="COG0366 Glycosidases"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q07837|8.A.9.1.2"
                     /protein_id="ACS46914.1"
                     /translation="MTANNMHDDWWKQAVVYQVYPRSFRDANGDGLGDIAGITEQVPYL
                     KHLGVDAIWLSPFYPSELADGGYDVIDYRNVDPRLGTLEDFDELVTALHAHGMKIVVDI
                     VPNHTSNMHEWFQAALTAEPGSPERDRYIFREGRGEHGELPPNDWQSLFGGPAWQRVAD
                     GQWYLHIFTVEQPDLNWKNPEVHEDFKKTLRFWSDRGVDGFRIDVAHGLAKDLDSKPLA
                     EMDADCVFDTDNRNGNNPLWDRAEVHDIYREWNAVFNEYRPARFAVGEAWVIPEHQHLY
                     AREGELGQVFNFEFAKANWNAAAFKVAIEDGIRSAHDAESTTTWVMSNHDVVRHASRYG
                     LPQVPTTGYHELPNDWLLRDGTTYIEDRDLGARRARAAILMELGLPGSVYVYQGEELGL
                     PEVANIPWNHLEDPIAFHTDHAGAQKGRDGCRVPLPWRADDEPRPADWDPLFGTGASFG
                     FSDAPADGSAPADPHLPQPLWYKQYAADKQMADDTSMFNLYRQAMQFRQEHLTPSDDTD
                     DITWLPGTDFNAHNAEVVAYTRPCTGEGDGTFACIVNFGPDPIDLPAGTVVLSSEPLDE
                     PHKLSADTAVWMLLP"
ORIGIN
        1 atgagcagca gtcaccaggt tccgcaatgg ctcgaccaag ccacgttcta cgagatctac
       61 ccacagagct tcgcggactc gaacgccgac ggcatcggag acatccccgg gatcatcgaa
      121 cacctcgatt acctgttgca actgggatgc aacgcgatct ggctcaaccc gctctacgag
      181 tcaccgttcc gcgatgccgg ctatgacatc agcgactaca agaaagtggc cgcacgctac
      241 ggcaccaacg acgatctcgc cgcactgttc gccgcggcgc acgcacgcgg catgcacgtg
      301 ctgctcgacc tcgtgcccgg ccatacgtcg aacgagcacc cgtggttccg ccaaagcgcc
      361 acggattcgc cgaatctgta cgacgaccgc tacatctgga ccggcaactg gatcgagggc
      421 ggcgacggac tgccgttcat cggcggcgag gaggcgcgcg acggcgcgta catcgtgaac
      481 ttcttcgcat tccaaccggc actcaactac ggtttcgccc acccgcgcaa aggctggcag
      541 gcaccggcac tcggcgacga ggcgctgcgc acctgtgacg cgatgctcga cgtgatgcgc
      601 ttctggctcg acatgggggc cgacggcttc cgcgtggaca tggccgacag cctggtgaaa
      661 ggcgacgacg aaggcaagcc gtacacgatc cgcacctggc agtacatgct cggacagatt
      721 cgcggggagt accccgaagc cgcattcgtc tcggaatggg gacgccccga cgaggcgttc
      781 gaggccggct tcgacatgga cttctacttg gattggcgtt gggacggcgt agccaacggc
      841 tatagcatgc tgctgcgcga caccgacacc cccatgctcc gcgatggcga ccacagctat
      901 ttcaacgccg attccggcac cagcatcgtg ccgttcctcg gcgaatacga accccggctc
      961 gaagcggcgc gcaaggcgca tgcctacttc gacctcatca cctgcaacca cgacaccatg
     1021 cgtctggtgc cgcgcctgac cacccgcgag ctggccctgg cctacagcac gatcttcctg
     1081 atgccgggtg tgccgttcat ctactacggc gacgagatcg gcatgcgcta ccgcaacctg
     1141 cccggcaagg agggcggcta cacgcgcacg ggttcgcgaa cgcccatgca gtgggacaac
     1201 agcgcgaacc acggcttctc gcaagccgct gccgacgccc tctacctgcc cgtggacgaa
     1261 cgcgaagacg cgccgacagt cgcggcggcc gtcgccgacg gcaactcgct ctggcaccat
     1321 atgcacgcgg ccctcgaaca gcgcaggagc accccggcct ttgcgccgga tgcggacttc
     1381 agcgtgctgt tcgccgagga aggcaggcgc cccttcgtgt tcaagcgcgc gaaagacggc
     1441 gtctccgcca ttgtggcggt caatccgggg cgcgacggcg agaccgtgac gctaccggat
     1501 gacgacggct ccgagacgcg caccatcacg ctgaacattg gtggggcggt actcgatggc
     1561 acaacgctca cgctgccccc gcaatccttc gccgtgctgc agtgacggtc ccggccgggc
     1621 gtacgcagtc gcccggccgg cgcccctcag cgctggatga aaacgtagtc attgcctatt
     1681 cagtgcaatc tgatgcccga cttttgcaat cggtagcata atccgccacc aacgcctcct
     1741 tcccgtggta tggactcgtc atcgcgctcc gcaacgatat gcagccacgc acggcgcagc
     1801 cggcgaatcc gcccatgcgc gcgccaactg ccggccgagc cggcgggtac agtctgcaaa
     1861 cgtgggcgtg aagaacacgt aaaaaccaca tggatcaaat tccgttcatt cgcatatctt
     1921 cgcggaatat aaaggaaaca ggcaccctca tgttatactt gcaaacgatt tcatagcacg
     1981 ctatactgaa atcggcagcg cactccaatg acgtaactgc gcacacatga cccatatcag
     2041 aaggaacgac atgtctcaga tcaattcagc acccccgcgc cgtgaggaaa gccccgagcg
     2101 actcgcacga ccgctcatcc agctcgccaa ggggtgcggt gtggccacct gctacataga
     2161 ccagctcggc acctatgtgg agattcgcga cgcagtgctc atctcggtgc tcggcgcgct
     2221 cggcgtcgac gcctccaccc cggagctcgt cgacatcaat ctcaacgcgc gacgcaacga
     2281 ggcgcacgaa cgcctggtgg cgcccaccgt cgtcaagttc ctcggcaccc ccgccagcac
     2341 gccgctgcac accaagcacg gggagcctca catcggactc acgctcgaag acggcagcga
     2401 cgcgaccgat gccctctcgc tcaccttccg cgagcatgat ggcgacgtgg acgtctacga
     2461 cctcgcgatc ggcgacaatc tggagatcgg ctaccacaca ctgcatgtgc gcgatggcga
     2521 aacgggcagc gagcgcgacg tcgacgtcac actgttgtgc gcgccggcat ccattccggt
     2581 acccgaggcc ctcgcctcgc acaagcgctg gggatggatg acgcagatgt attcggtgcg
     2641 ctcccccgaa tcgtggggcg tgggcgacta cggggacctg cgcgaactgc tggtggacgc
     2701 cgccggctcg ggtgccgact tcatgctcat caatccggtg catgcgagcg cgccggtgag
     2761 cccgatcgaa ccgtcgccgt attcgccgat gtcgcgccgc ttcatcaaca ccacctacat
     2821 tcgcccgcag gacatcgccg aattcgccga gctcgacgag caggacgccg ccgccgtacg
     2881 cgcattgcac gagcaggtcg cgccaatgaa caccgaatcg tcgccgatgg atctcgacgc
     2941 cgcctggaag gcgaaacgcg ccgccttgca aatcatcttc aggcagccgc gctccccgga
     3001 acgtcaggcg tcgttcgagg cgttcaagga gaaggccggc gccgacctcg acacctgggc
     3061 actgtggagc gtcgcattcg aagtgctcgg ggagccatgg gagccggact cctggttccg
     3121 catgaccgcc aaaagcaatc cgcgcatcca ggcgctgcga accgagcatc ccgatctgta
     3181 tgagttcgcc tgctggctgc agtggatcgc cgaggagcag ctcgacgcgg cccagcgtgc
     3241 cgcgcgcgac gctggcatgt cgctcgggct catgcaggac atggccgtgg gcgtgcactc
     3301 ctacggtgcg gacgcatggg gcaacccgga acgcttcgcc gtcggctccg tcacggtggg
     3361 ctgcccgccg gacttctaca atcaacaggg tcaggattgg ggccagcctc cgctcaaccc
     3421 gaactatctc gagctcaccg gctaccgcat gtaccgcgag atggtgcacc acatgttcga
     3481 acatgcgggc gccattcgca tcgaccacat tctcggactg ttccggctgt ggtggatccc
     3541 ggccggccag ggcgccaagg gcggcgcata cgtcacctac aactacgatg cgatgatcgc
     3601 ggtgctcagc atcgaggcca cgcgtgtaaa cggcatcgtg atcggcgagg atctcggcac
     3661 cgtgcccgat ttcgtgcgca atgtgctcgc acgacacggg ctgctcggca ccacggtgga
     3721 gtggttcgcc cgcgtggacg actcccccaa cgccggcgac ccgtacgcga tgccgcagac
     3781 gtaccgcaca tactcacttt cgtcggtcac cacacacgat ctgccgccga ccgccggcta
     3841 tctcatgctc gagcaggtca aactgcgcga ggagctcggc ctgctcaccg agccggtgga
     3901 ggagttccgc gaatccgcgc tcgccgaacg gcaggccatg ctcgacctgc tcgtgcaggg
     3961 cggctggatg agtcaggagg ccgccgacga tgtgccggac aatctgcaga ccattgtcga
     4021 ggcgatgcac gccatgctca ccgacgcgcc ttcgctgctg ctgcaggccg cgctcgtgga
     4081 cggcgtgggc gaggcgcgcg cgcagaacca gccggggacg tccacgcagt acccaaactg
     4141 gcgtattccg ctcgccgacg agcatctcaa ggtggtgccc acgcaggagg tgttcaagtc
     4201 gccgcgcgtg caggcgctgg cgaagatcat gaaccgcatt aatcagtagg cgcgcataca
     4261 cactgcatat cacactgcgt atgttgcata tgcgaaaggc ccatgggttc cgcgcccatg
     4321 ggcctttctc gtgccgtttt tgcaatctca gtctcggcat ggcttgccag caacgccgtt
     4381 ccatgccatg gtgagggcag acttgcagtc tcgacacagc aatcgccccc tccctaacca
     4441 tgatgagaac agacttgcaa atacgacacg agaatgcgcg ctccggctgc ccatctgaag
     4501 atgggttcgc aagaccagca cggtaattta tgctgccgat gccgatctaa gagctgattc
     4561 gcaaaagcgg cacgcgaatc caacattgca tcatcaatct gagagcagat ttgcagatgc
     4621 agcatgcgaa tcggcagcgc attccgctag gaaacggata cgagtcggca ggcccgcgca
     4681 cgacacgtcg aacacgggac tgccggcgac atgcgcgcgc ctattgccgc gtgtaccggc
     4741 gcagtgcgta ttcgagaatc ggcacgtgca atgcgagcat gcaaccgtaa ccgagcacga
     4801 cgagcaggaa gagcccctgc ggcatgtaga accatgcggc gacgagcaga cccacgaaca
     4861 cgacgtcgat cgccacgcag gcgagcgtcg cggggaagta gacgacgccg aacacgtagg
     4921 cgttgcgcag ggtctggcca agggggttct cgaaacgcgc ctgcaaatag aatgcccatt
     4981 cgaagccgat ggcccagatg atcgtcagcg cgaatttcgg aatgagcagt ggggtgatct
     5041 gcagcacgat ccacgaatag gcgattgcgg cgccgcagat gccgaagatg agccatagca
     5101 gcgtcgcctt ggcgagattc tcgcggaagg cggcgaaata gttgcgcgtg accgtgccct
     5161 ggccgcgctg cgatttgcgt agcgcggtgg aaccggcaca cagcgcggcg ccggcggtga
     5221 ccacgggcag cgatgtgacc agcatgagca tgttgatcca gatagcgtcg gtgagatcgt
     5281 tccacccctg catgaatctg gagtctggag acaggaattt catctgcgtc gctttcgtcg
     5341 gtgccgggca caatctggcc ggcgtatagc atgcaccagc ttactccagt gcagttcggg
     5401 aaatctggtt gatgtgaatc aggccggcat gccggcatat gcgactgggg gcagcccgaa
     5461 agccgccccc agtcgccttg agagagaaga ggaaggaaga ccagcccttt acggcaccgc
     5521 ctcgggccct gcaagtattg accggcctac ggccggaccc aacaccgccc tcgcggcaca
     5581 gccgctcggg ctggcacctg caaacagcgc accacgctgt ttcccaaggg ctgactcaac
     5641 gtcagccctt tacggcacca gccatgacac ccttgacgat gtacttctgg cagatgaggt
     5701 agaacacgat gatcgggatg atcgcgagca cgaggcaggc catcatcgca cccatgtcga
     5761 ccgagccata gccgcccttc aggtactgca cggccaccga gatggtcttg tacttgccca
     5821 gatcgagcgt cagatacggc agcaggtagt cgttccacac ccacatggcc tcgaggatgg
     5881 ccacagagac gatggacggc ttcatgattg gcacgaccac ctggaagaag atgcgtggca
     5941 ctgaggcgcc gtcgatcatg gccgactctt ccagcgactg cgggatgccc ttgaccacgc
     6001 cggtgaagat gaacaccgcc agaccggcgc cgaagcccag gtagatgaag cacaggcccc
     6061 acggggtgtt gagcttcagc atgtcggcga gcttcgacag cgtgaacatg accatctgga
     6121 acggcacgat catgttgaac aggaacaggg tgtagagcag cttggcggcc cagttgttca
     6181 cgcgcacgat ccaccatgcg cacatcgacg tgcacacgag aatgaggcac accgagccga
     6241 cagtgatgag caccgtccag ccgaagctgg cgaagaagtt cgtggattca atgccgcgct
     6301 tgtagttctc gagcccgacg aacgtgtcgc ccaccgggaa cgcgaaggcg ttgcgcgaga
     6361 tgtatgcctt gcctttgaac gagttgagca gcaccaggaa gatggggaac acccaggcaa
     6421 tggagatcat cgagaagaag atcgtccaca atgctccgtg ctttggtttc tcctgcatca
     6481 cgcatcaacc tccttggaag tggtgatctt gttctggatg agcgccacga tggccaccag
     6541 gatgaagaac aggacggcct tggcctgccc cacaccctcc cagccgatac ggccatagaa
     6601 tgtacgggtg atgttgagcg ccagaccttc cgacatgttc tgcggagcgc cgttggtgag
     6661 cgcgaggttc tgatcgtaca gcttgaatcc gttggtcacg gtgaggaatg agcacacggt
     6721 gatgctcggc atcatgagcg ggatgatgat gcggaacatg acctggcggc cattcgcgcc
     6781 gtccacttcc gcggcctcaa gcacatcggt gggcagcgac tgcatgccgg cgatgtagat
     6841 gatcatcatg tagccgatct gctgccagca cacgaggatc accaggcccc agaacccgta
     6901 tttcgccgaa tacgtgagcg agcgctccca gtgggcgagc acgccgttga gcagcagcat
     6961 ccagatatag cccagaatga tgccgccgat gaggttcggc atgaagaaca ccgagcggaa
     7021 caggttggaa ccgcggatcg acttcgtcag caaatacgca atggcgaacg cgacgacgtt
     7081 gatcactatg gtggtcacga tcgtcatgag cgtggagaat ccgagcgcgt gcaggaattc
     7141 cttgtctttg atggcgcgcg cgtagttctg ccagccgatg aacttggcgt cggtgaccgt
     7201 ggtgaacgag cagaagctca agtagatgcc gtagatgaac ggcaccagga agccgatgaa
     7261 aaacgcgacg aatgtcggca gcacgaacag cgcccaccat cgtctgattg ccttaccagc
     7321 catgctgatc atagcatgcc tactttctcc tcttcgagtt cgccccacac cactgtgggg
     7381 caatgccatg tcccggttca tctgcagtca ctgcaaacga ttacagaacc gttgtactca
     7441 tacgatagca acatcgtcat cttctgtcaa acgtttgcat tcgtgtcgtg ttgaatgtaa
     7501 tgcttctttt cacaaatcac agatctttac tgcatttcca gcgttttctg taatcacata
     7561 gcgtagactt gatattgaaa acgtttgcgc aaaatgtcta agcaaatcct agatcatgcc
     7621 gctggggcca ccgacgcccg cccatgcgcg accgctcgcc ggattaactg tcagccatgt
     7681 ggatgcaaca tgtttgcaat acggtatgca cacgcggcgg caacgggcgc aatcgtatgc
     7741 tgtatagagt cgagcgaagc gaggcaaccc gcttcccgaa caaggagggc agaggtgaac
     7801 gcaagcattc aggatgtggc caaggcagcc cacgtctcca tttccacggt ctcccggtca
     7861 ttcacacgac ccgagctggt gtcggcggcc acacgagaga aggtgctgcg catcgccgag
     7921 gagctcaatt tctccacatc gcgctcggcg gccgcactca agaccggccg tgccatgcgc
     7981 gtcgcgctgc tcatgagcga ccatattcgc ctgtggttct cggcgtccgt gatcgaaggc
     8041 ctcaactcgg tgctgcatgc cgaaggctac gatatttcga tcttccagat ctccagcatc
     8101 gaggaacgcc gcgatttctt cgagatgctg ccggtacgac gcaatgccga cgccgtgatc
     8161 gtcgcctcct tcgacgccga cgagaccgag atcgcccagc tggcgagcgc caacgtgccg
     8221 atcatcggca tcaactcggt gatgccgcgc gagcttggat tcaccgcggc cgtgaacatc
     8281 gacgacacac agggctccat tctcgccgcg cgccacctga tcaatctggg gcaccgcgac
     8341 atcgcctacg tgcgcacgaa ccgcgacgtc tcactgcact tctccgtgca gcagcgcttc
     8401 gattcgttca tggaatgctg tgcaggctcg ggaatctccc ccaccgtgat cgtggcgcag
     8461 gagggtccgg atcgcattcg ccgcgtactc accgacctca tgagcctcga gcgcatgccc
     8521 accgccattg cctgccagga ggacggcatt gcggtgccgc tcatcttcca actcgagcgc
     8581 agcgggtacg aggtgccgaa cgacatctca gtgatcggct acgacaacag tttctacgcg
     8641 aacgacatcg gtctgaccac gattgcacag gatccgatcg agatggcgaa gatggccgct
     8701 gaaatgaccg tcaagctcat cgagggcgag aagcccgagc atctgttccg cacgattccg
     8761 gcggaacttg tcgtgcgttc gagcaccgcc aagcacgtcg cctgacgctt cgcaacaccc
     8821 ccgcctctta cgcacaggga gtaagcgatc caagataaac gacgtaaaag gggacagaat
     8881 tagcgtaatt ctgtcccctt ttacgcatct ttatgccccg ccagcgaacg atcccggcac
     8941 tttctgcgta aaaagacaaa accgcaccgg aatatgtccc cgtttacgca gggaggaagc
     9001 ttttttaatg caagagaagg aacgtgtcca tatacacaaa gtccatatac acaaagagga
     9061 gggccacccc aatggggtgg ccctcctctc gctagttatt cagcatgggt tccacgtgga
     9121 agaagtggac gcggaatcca cgcccccatt cagcgctcac tggttggcgt gggcgttgtc
     9181 gtactcggtc ttccagttgt cgacgaaggc cttccgcacg tcatcccagc tgccggtgcc
     9241 ctgcgcgtag gcgagcatgg cctggccgag ctggttctgc cactcctccg acggcatcat
     9301 cgtgaagttc ccggcgacct gctgcttgcc ggatttggag tcctcgacgg cctcctcgac
     9361 gagcgggttg tcgctcttca ccttgtcgaa ggtcttgaac ggcgtggtga agcccatgtc
     9421 ttccgacagc gccttgatgc cctcatcgga ggtgacgacc cagttcagga agtccttcga
     9481 ggccttctgg tcggcctcgg aggccttcgc attgacgcac aggcagttct cggaactggc
     9541 ggtggccagg ccttggttct cctcgccctt ggcaccgatg tagatcggga gcatacccac
     9601 ctgatcgggc ttcatgccgg ccttctgcag gtcggcccat gcccaggtgc cgttctggta
     9661 gaacgcggcc tcgccgagtg cgaactcgga gttcgcgtcg ttaccggtct tcgagctcag
     9721 ctgagacggg gcggtggtgg aatccttgag gtacaggtcg aagatgttct tgaagttcgg
     9781 caggtaggtg cccttgatcg tctccggctg cgtggtcaca ccgtcctcct tgaactcata
     9841 ggagagcggg atgttcgcca ggtgggcctt gaaacgccag tcggagctgg agtcgaagcc
     9901 tgcggaggtg aaggcgccct tgatgccgag ctggtccttc ttggcctgca tgtcgtcaga
     9961 gacttccttg agcttgtcga aggagttgat ctccttggcg tccttgatct tggcgcccgg
    10021 cagctcggtg tacttcttga gcaggtcctt gttgtagatg atgccgtagt actccacgac
    10081 gtacggaacg cccacgacct tgtcgccgtc cttcagcgcg ctgtccttgt tgttgagctc
    10141 gttgtagatg ccggtgtcct tgaggtcggc ggtgtagccc ttccagttct ggtagtccac
    10201 ctggccgttg acctggaaga tcgtcggcgc atcgctcttg gcgagctcgg acttgagcgt
    10261 ctgctgatag gtgcccgagg cggccgtctg caccttcacc tgcacgccgg tcttgtcggt
    10321 gtatttcttg gcgagcgcga cccactggtc ggcggtctcc ggcttgaagt tcaggaagta
    10381 gaccttgccc ttgccgtcgt ccgcgctgct tccgccacac gcggccaagc cggtcagaga
    10441 cattgcggcg atcgccacga gacccactgt tgctttcact gtgcgattca tcttcgaacc
    10501 tttcctcatc ccacttcagc cactcaccga agtggcaccg aagtattttc ctgaagccgc
    10561 gccctcgcgg acttcgtagc cccttcatta tgcatcattc ctgagcagat tgcaaacgtg
    10621 ggcagtaagt ttgcgtacaa attgtggaga ttgccgtgca gattgactca aaaatacttt
    10681 attttcaacg cttttcactg cgacacgcac tatgcaagcg tttgctcacg atctgcaaac
    10741 atgggcgttt cgcacagcat tacgtctcca gacgacacgg cggggcgacc gggcaaacgg
    10801 tattacaatg gttcctgaat ttgtttccaa aaacaagaaa agagcttcca tgaccgcgaa
    10861 caacatgcac gacgactggt ggaaacaggc cgttgtctat caggtgtacc cgcgtagctt
    10921 ccgcgacgcc aacggcgacg gactcggaga catcgccggc atcaccgaac aggtgccgta
    10981 tctcaagcac cttggcgtgg atgccatctg gctctccccg ttctaccctt ccgagcttgc
    11041 agatggcggc tatgatgtga tcgactaccg caacgtggac ccacgtctgg gcacgcttga
    11101 ggatttcgac gaactcgtga cggcgctcca cgcgcatggc atgaagatcg tcgtcgacat
    11161 cgtgccgaac cacacctcga acatgcacga atggttccag gcggcactga ccgcggaacc
    11221 cggctcgccg gaacgcgacc gctacatctt ccgcgaaggg cgcggcgaac acggcgaact
    11281 gccaccgaac gactggcagt cgctgttcgg ggggccggcc tggcaacgcg tggccgacgg
    11341 ccaatggtat ctgcacatct tcacagtgga gcagccggac ctcaactgga agaaccccga
    11401 ggtgcatgag gacttcaaga agacactgcg cttctggtcc gaccgtggag tggacggatt
    11461 ccgcatcgac gtggcgcatg gcctcgccaa ggatctcgac agcaaacccc tcgccgagat
    11521 ggacgcggac tgcgtgttcg acaccgacaa tcgcaatggg aacaacccgc tgtgggaccg
    11581 cgccgaagtg cacgacatct accgtgaatg gaacgccgtg ttcaatgaat accggccagc
    11641 acgcttcgcc gtcggcgagg catgggtgat tcccgagcac cagcacctct acgcgcgcga
    11701 aggcgagctc ggacaggtgt tcaacttcga attcgccaag gcgaactgga atgcggcggc
    11761 gttcaaggtc gccatcgaag acggcatccg gtcggcacac gacgcggaat cgaccaccac
    11821 ctgggtgatg agcaaccacg atgtggtgcg tcacgccagc cggtacggtc tgccgcaggt
    11881 gcccaccacc ggctatcacg agctgccgaa cgactggctg ctgcgcgacg gcaccacata
    11941 catcgaagac cgcgacctcg gcgcgcgccg tgcccgtgcg gcgatcctga tggaactcgg
    12001 cctgccgggc tcggtgtacg tgtatcaggg cgaggagctc ggccttcctg aagtggcgaa
    12061 cattccgtgg aatcatctcg aagacccgat cgcgttccac accgaccatg ccggcgcaca
    12121 gaaaggccgc gatggctgcc gcgtgccact gccatggcgt gccgacgacg aaccccggcc
    12181 tgcagattgg gatccgctgt tcggcaccgg agcctcgttc gggttctcgg acgccccggc
    12241 cgacggttcg gcgccggccg atccgcatct gccgcagccg ttgtggtaca agcagtatgc
    12301 cgccgacaag cagatggctg acgacacctc gatgttcaac ctgtaccggc aggcgatgca
    12361 attccgccag gaacacctga cgccgagcga cgacaccgac gacatcacgt ggctacccgg
    12421 caccgatttc aacgcccaca acgccgaagt ggtcgcctat acgcgcccct gcacgggtga
    12481 gggcgatggc accttcgcgt gcatcgtcaa ctttggcccc gatccgatcg acctgcccgc
    12541 aggcacggtg gttttgagct ccgagccgct cgacgaaccg cacaagctgt ctgccgacac
    12601 tgccgtctgg atgctgctcc cctga
//
