LOCUS       AAZZ01000003           16495 bp    DNA     linear   BCT 22-MAY-2007
DEFINITION  Streptococcus pneumoniae SP3-BS71 ctg567, whole genome shotgun
            sequence.
ACCESSION   AAZZ01000003
VERSION     AAZZ01000003.1
DBLINK      BioProject: PRJNA17957
            BioSample: SAMN02393743
KEYWORDS    WGS.
SOURCE      Streptococcus pneumoniae SP3-BS71
  ORGANISM  Streptococcus pneumoniae SP3-BS71
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16495)
  AUTHORS   Hiller,N.L., Janto,B., Hogg,J.S., Boissy,R., Yu,S., Powell,E.,
            Keefe,R., Ehrlich,N.E., Shen,K., Hayes,J., Barbadora,K., Klimke,W.,
            Dernovoy,D., Tatusova,T., Parkhill,J., Bentley,S.D., Post,J.C.,
            Ehrlich,G.D. and Hu,F.Z.
  TITLE     Comparative genomic analyses of seventeen Streptococcus pneumoniae
            strains: insights into the pneumococcal supragenome
  JOURNAL   J. Bacteriol. 189 (22), 8186-8195 (2007)
   PUBMED   17675389
REFERENCE   2  (bases 1 to 16495)
  AUTHORS   Ehrlich,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2007) Center for Genomic Sciences,
            Allegheny-Singer Research Institute, 320 E. North Ave. 11th Floor,
            Pittsburgh, PA 15212-4772, USA
COMMENT     
            Contig AAZZ01000019 was removed because it may contain
            contamination.
            Annotation was added by the NCBI Prokaryotic Genomes Automatic
            Annotation Pipeline Group.  Information about the Pipeline can be
            found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html. Please be
            aware that the annotation is done automatically with little or no
            manual curation.
FEATURES             Location/Qualifiers
     source          1..16495
                     /organism="Streptococcus pneumoniae SP3-BS71"
                     /mol_type="genomic DNA"
                     /strain="SP3-BS71"
                     /db_xref="taxon:406556"
     gene            complement(1..1767)
                     /locus_tag="CGSSp3BS71_10393"
     CDS             complement(1..1767)
                     /locus_tag="CGSSp3BS71_10393"
                     /note="COG2407 L-fucose isomerase and related proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="EDK74347.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKY
                     PDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHA
                     IWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTAIPEDVKEKLLRYARA
                     ALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDP
                     EEFERALKWVKENVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNPRLADL
                     GFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLN
                     GVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSGSCTLDGT
                     GQAIRDGKPVMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMV
                     RLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDV
                     MNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESAD
                     YRACQLLGPLHK"
     gene            complement(1780..2508)
                     /locus_tag="CGSSp3BS71_10398"
     CDS             complement(1780..2508)
                     /locus_tag="CGSSp3BS71_10398"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose phosphate aldolase"
                     /protein_id="EDK74348.1"
                     /translation="MSQDEKLIREQICDVCHKMWQLGWVAANDGNVSVRLDEDTILATP
                     TGISKSFITPEKLVKLNLKGEILEAEGDYCPSSEIKMHIRCYEEREDVRSVVHAHPPIA
                     TGFALAHIPLDTYSLIESAIVVGAIPITPFGVPSTMEVPEAITPYLPDHDVMLLENHGA
                     LTVGSDVITAYYRMETLELVAKTTFHGRMLLSTKGIEEQEIARPTLERLFSMRENYKVT
                     GRHPGYRKYNGDGSMKETEK"
     gene            complement(2523..5540)
                     /locus_tag="CGSSp3BS71_10403"
     CDS             complement(2523..5540)
                     /locus_tag="CGSSp3BS71_10403"
                     /note="COG0235 Ribulose-5-phosphate 4-epimerase and related
                     epimerases and aldolases"
                     /codon_start=1
                     /transl_table=11
                     /product="GH98|CBM51"
                     /protein_id="EDK74349.1"
                     /translation="MESKKIAKQILIATAVLTSFLGSNLVYADVVQSNSNNRASTETAR
                     VTGNNLEKLITKDKEIDKEMTYLSDMDWSSATHGDIDKTKTVQKDAPFTTGNKGEHTKI
                     SLLTSDDKVKYFDKGIGTVADSPSVISYDISGQGFEKFETYIGIDQSANSSRSDHAVVD
                     RIEIEIDGKVVYSSSVTNPEGFRYNTQAQFISVTIPQNAKKISLKSFAGEHTWGDEVVF
                     ADAKLIKTVSTQTITPDLLNKGINGGVYLSDLEWVDATHGDDDKSKTVQKDKPFTPGNN
                     GSNNKIKLLIDGKEVEFNKGLGTVASNPSSIKYDVSGANVTRFISYVGIDRSANHLNSD
                     YADIQKFEVVADGKVIYSSDSKYPKGIKYDTSAFLVDVEIPKDTQTIELKSYSGKHTWA
                     DELVLGGALFMANGKFKNPNDWSEVDKRREINNEHPLLMMPLYANGEEFNQGKYTFWGG
                     DTLTGKWENIPDDLKPYTVIQLHPDDLPKRDGAARDFYEHMLEEAAKYVNPKTGKNEPI
                     PVILTVYTAGNMPYYTSAHWLSTSWIDKMYQKYPNLHGIFSTENYWIWANDIENKAADY
                     LKVSAKNGGYFIWAEQNNGSAIEKAFGKNGKIAFQKSVDKYWKNLIFMFKNTPAAEGND
                     STTESYMKGLWLSNHTYQWGGLMDTWKWYETGKWKLFASGNIGKSQGDRQWLTEPESML
                     GEEALGVYLNGGVVYNFEHPAYTYGVNNKESLLFSEVIKEFFRYVIAHPAPSKEKVLED
                     TKVFIHGDYSNKGNGKFFVNVNTDREQTPLYMTGRYNVIPAIPGVLKTDKLKESVSSSR
                     IQIKEITSPEFSSTQARKEYLNKLYPMNYEGDIFAQKLDNRWFVYNYKVNENVKQTGKL
                     KFNSLEMNVEFEPHTYGIFERISNGLKVNLNNFRTNKDSLWSNAQDANQAKKLPQLTKK
                     GAIKWIEEHYIKDTQFGEKRVTKIVLRGIDKLPTIHSLSGTNNSYDQPSLNFDQKNHMV
                     TITINSNGNLEFELHF"
     gene            complement(5551..7767)
                     /locus_tag="CGSSp3BS71_10408"
     CDS             complement(5551..7767)
                     /locus_tag="CGSSp3BS71_10408"
                     /note="COG3345 Alpha-galactosidase"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="EDK74350.1"
                     /translation="MTIYINKDETVFHLAMKDSSYIFRILENGELQHLHFGKRIHVKEN
                     YNQLMAYKKRGFEVSFSEEFEDIQQSMIQNEYSSYGKGDFRHPAFQVQGMNGSRITTLK
                     YQGFELEKGKNRLNSLPSTFDDIGQCAETLTIILTDSILDLTVRLNYTIFPEYNVLVRN
                     TEFLNNSNNKLTLLKAMSLQLDLPDSQYDFIQFSGAWLRERQLYRTSLRPGIQAIDSLR
                     YSSSPQQNPFFMLSRRETTEHSGEVYGFNFIYSGNFQNMIEVDHFDTARVTVGINPVEF
                     RFLLNPAESFVTPEAIVIYSDQGMNQMSQQLSDFYRHHLVNPNFSQASRPIILNSWETF
                     YFDLGTEKILDLAKAAKDLGIELFVLDDGWFGHRKDDKSSLGDWVTDRSRLPEGIGFLA
                     DEIHKIGLQFGLWFEPEMISIDSDLYKNHADWTIHLLDREKSVGRNQYVLDLTRQEVVD
                     YLFDSISKIIIKTNLDYIKWDMNRHITDIYSIELDSEQQMEFGHRYILGLYQLLDRLIT
                     KFPSVLFESCSSGGGRFDLGLMYYAPQAWTSDDTDPIERLKIQHGTSYGYSPSMMTAHV
                     SISPNEQSGRQTSLDTRTNVAYFSSFGYELDVTRLSVEEKEQVREQIQFYKKYRSLFQY
                     GDFYRINSPFSCDSASWQVVSKDKCQSILLYAQLNSKLNPGYTRVYFSGLDKDKCYSVS
                     RFDEFFYGDELMNAGIKVSLSNLALCVPEYLTKLFVIEEVVCKY"
     gene            complement(8007..9659)
                     /locus_tag="CGSSp3BS71_10413"
     CDS             complement(8007..9659)
                     /locus_tag="CGSSp3BS71_10413"
                     /note="COG3345 Alpha-galactosidase"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="EDK74351.1"
                     /translation="MKIENKNVRRNFFWGEGRFYTTDIVNKRAGVMIKNVSKEEFTITL
                     ENGIKLSSTHFSAIVREEGDTRIQVSFVCPSIRLRLIFESRDDVLSKQLVLESSTEVIK
                     SVEVESFEFETEDNIFYPKRQDCIKEMANFSGYYVELGQPVYANSLFLGMEFPMSENKV
                     DGRHYVSRYYLGTVVNQEKSLWSCIIGGACSYKKEEIQEAFFEYVEGIAQPSYFRKQYN
                     SWYDHMTDITEEGILKSFSEIRDGFENHGVHLDAYVVDDGWTNYQSVWEFNHKFPNGLR
                     NIKYLVNGFGSSLGLWIGPRGGYNGTEIIMSDWLEAHPELNIGSKNLISNDVNVADFNY
                     LNQMKKKMLEYQKEFDISYWKIDGWLLQPDKPDKSGPHGMYTMTAVYEFLIQLLIDLRK
                     ERGGKDCWLNLTSYVNPSPWFLQWVNSLWIQISQDVGFTENAGNDINRMITYRDSQYQE
                     FLEKREIQLPMWSLYNHEPIYAVSANTWYMDHQMFASIPDFEAYLLFISTRGNAFWEFH
                     YSFDMFDEERWKANARAVKWIEENYQTLKYSKK"
     gene            complement(9665..10972)
                     /locus_tag="CGSSp3BS71_10418"
     CDS             complement(9665..10972)
                     /locus_tag="CGSSp3BS71_10418"
                     /note="COG1082 Sugar phosphate isomerases/epimerases"
                     /codon_start=1
                     /transl_table=11
                     /product="GH29"
                     /protein_id="EDK74352.1"
                     /translation="MKLSIVEFSGLEKQDLGCSFIGGLYSIPGKGEWIRSHQKLSIEDY
                     EPYFRAFDPKEYNPREWAKQAKAAGMKYMVLTAKHHDGFCLFDSKFTDYKATNTPAGRD
                     LVKEFVDAVRAEGLKVGLYFSLIDWHHPDFPKYADLNHPMRGNEVYRDEKINFDSYLEY
                     LHNQVKEIVTGYGQIDILWFDYSYEDMVGEKWGASKLIDMVRHYQPNVIVDNRLETSGE
                     GFGSIVTDEITSYAGDFVSPEQIVPHEGIRNFKGEPVPWELCLTMNNNWAYNPTDYLYK
                     SSQTLIRKLVECVSKNGNMILNVGPDALGRINDSSKKILDNFHRWMSRNGEAIYGCSGD
                     ENLPKPDWGYYTRNGNTVYAHVFEQPIGPLALLGISKENVKRMSFLHDGSEVKISESWT
                     TNAYKGICFAQFGEVPHFTYPLPDLIDSVIKIELRE"
     gene            complement(10982..11827)
                     /locus_tag="CGSSp3BS71_10423"
     CDS             complement(10982..11827)
                     /locus_tag="CGSSp3BS71_10423"
                     /note="COG0395 ABC-type sugar transport system, permease
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A5LBQ4|3.A.1.1.47"
                     /protein_id="EDK74353.1"
                     /translation="MIMNTHINGISKKGKVLIYGYMLLTILISIFPIAWIFLSSLKADP
                     MKNPGISLPTDFTLEGYINVFTKLHVFTYFWNSFKVVSISVIISIVMISMSSYVIARME
                     FRGKKLVTSMLYSTLFIPATAMTFPVYRLVNELGIYNTPVALILVYSCSGIAMSFFIIK
                     NYFEIIPKELEEAAEIDGATYAQTFWKVMLPIARPGILTAAVLAFINNWNEYYWASMLV
                     IDKNELTVPALLGQFTTSFNTNYNGLFSAIVVIVLPPIILFAFTSKYFIEALGGGAVKG
                     "
     gene            complement(11824..12753)
                     /locus_tag="CGSSp3BS71_10428"
     CDS             complement(11824..12753)
                     /locus_tag="CGSSp3BS71_10428"
                     /note="COG1175 ABC-type sugar transport systems, permease
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A5LBQ5|3.A.1.1.47"
                     /protein_id="EDK74354.1"
                     /translation="MAQKIMSLQNRKNQKRRFIFLFLLPTLICFFLFYFYSVVTIFLTS
                     FAKWDYTNLNTPEFLGFDKLFENYRYVFKEYPFFTEALINSVRWAVIGVIIQVPLAVSV
                     AITLSKKLKGWKISRNLYIVPSIISSAAMGLIFLQIYNPNYGVVNQIIHLFNPSFKDSV
                     LLTPGLNIVAMTGAYIFFAGASTIMILGQIFAIPEEVQEAAILDNITGWRKEWYITIPM
                     IKGTIKTVSIMAATSGFLLYNEVFFLTNGAAGTKSISFVIRELAVASSRTQYARANTIG
                     VIQILGGMLIIVCINILFRERKRLKGEK"
     gene            complement(12840..14132)
                     /locus_tag="CGSSp3BS71_10433"
     CDS             complement(12840..14132)
                     /locus_tag="CGSSp3BS71_10433"
                     /note="COG1653 ABC-type sugar transport system, periplasmic
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|A5LBQ6|3.A.1.1.47"
                     /protein_id="EDK74355.1"
                     /translation="MNKKSLLKCAVIGLVATFGLAACGTSKDASGGSSSGKEVLEFYHG
                     YHHSEDEWPVAKTMRDLYDKFAEEHKDSGVEFKPTPVNGDLKDIMNNKVASGEFPDVID
                     LAGNAVSLAAIEQKLVLDLKPYIDSNKLEKNVGLNYKQNQKDGKIYTVHEQLFTMGLWY
                     NKDIFAKAGAKTPDQWNTWDDFTQAMASIRKQDGVYAFGAGEPSIRLFNTVLGTTENGR
                     KLLDKPLTKEGIESKEFADALKMVMKEIQANGSKNAGGDANAYSKDFQEGKSAVFFNGV
                     WASGEMSKNPSLAPGIYPAGVAISSSGGGITISSKMSEAKQKLALEFLKYMTSDDVQKV
                     IFEKVGANPSNENVNVKELSEKSSEATTKILGQAITQVKNAKAVVPTVSDVWGGDVHTA
                     IINALTESAAENVDVDQKVKSTQDVLKSLIG"
     gene            complement(14161..15564)
                     /locus_tag="CGSSp3BS71_10438"
     CDS             complement(14161..15564)
                     /locus_tag="CGSSp3BS71_10438"
                     /note="COG1070 Sugar (pentulose and hexulose) kinases"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose kinase FucK, putative"
                     /protein_id="EDK74356.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGHL
                     SWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLSQPVHYRDERTKG
                     VLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFNYLL
                     TGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDLSLLPEIVSEGNVLGRIKEEYGLG
                     DIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGFTNEVG
                     KDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTESTEFAT
                     ESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKVYKRIYVI
                     GGGARASYFNQMIADRTGKEVLTGSTEGTAVGNIVVQLLSQGKINEDTELKDIMTNIAD
                     TKYYYPQLS"
     gene            15740..16495
                     /locus_tag="CGSSp3BS71_10443"
     CDS             15740..16495
                     /locus_tag="CGSSp3BS71_10443"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_DeoR,DBD-SUPERFAMILY|0043758"
                     /protein_id="EDK74357.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLEN
                     QGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCIYLDSSTTV
                     YELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKENSL
                     LDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTGFFKI
                     NPLSKYTTFISDTVPDQKLLDAVELFDGE"
ORIGIN
        1 ttatttatgt agtggtccca acaactgaca tgcacgatag tctgctgatt ctagatcttc
       61 tgttccaaat aaggaccaat ttttaggtct aaagatatct tcctcaggta cattatgcat
      121 attgacagga attctcaaca tagaagccaa ggtaatcaag tctgctccaa tgtgtccata
      181 tgttatggct ccgtgattag ctccccaatt attcatgacg tcatagacag acttgaaagc
      241 accttttcct gtcaaacgtg gagcaaacca agtagttggc catcctggat ctgtacgatt
      301 atctaaagta tggtgaacat cttcaggaag ttcaagtgta taaccttctg caatttgtag
      361 cactggacca acccctttta gaagattgag acgtaccatt gttactggca tatccccctt
      421 cgtcaagaaa cgagttgaga atcctcctcc acggaagtat tcgcggtttg ctggtgggaa
      481 gtctgtattt tcaagcatag cctgcacttc actttcttcc aactcccaga atggtttcat
      541 aacaggtttg ccatctcgaa tagcttgacc tgtaccatcc aatgtacaag aaccagagtt
      601 gattagatgt aagaagccag ctgcagcacg accctctaaa gtatgtcccg ttacacgttt
      661 aacagcctct ggactccaat aagtacgcac atcagcaaat atttgtggag tatttgttaa
      721 tagataatta aagagcatag acacaccatt tagtgaatca ttctctgtcg caaatacaaa
      781 tggttttcga ataccattcc agtcaaactg agtattgagg aaagtttcca taaagtcccc
      841 atttgggaaa tggtctgtcc actggcgttg accttggaaa ccagctacta aagcatggtg
      901 accaactgct tcttcttcaa aaccaaggtc agcaagtctt gggttaccaa ccattaagtc
      961 acgtccaatc atgaacatct taataacaaa ttcccattgt ctatcttttt cttcacggct
     1021 taaaacaagg tcttcacggt tatggtcgaa tccttctttt acgttttctt tcacccattt
     1081 gagcgcacgt tcgaactctt cagggtcgta aataccacgg tccatacggc gtgtgaactc
     1141 cgtcatatct accgattcat ttcgcattcc taagtattct tggaagaaat ccggatttac
     1201 aatagaacca ccaatcccca tcgaaacact acccattgat aggtaagcag tgtctctcat
     1261 caagccagtt gcaagagctg cccgcgcata acgtaaaagt ttttctttga catcttctgg
     1321 aatagctgta tcattagctt cctgaacatc tctaccataa atcccaaagg ctggaatccc
     1381 tttttgagca tgtgaagcta gtacagctgc aagatagaca gctcctgggc gttctgtccc
     1441 attaaatccc caaatagcat gaggaatatc tggagacata tccatagttt cactaccata
     1501 acaccagcat ggtgtaactg taattgttgc gcaaacattt gattttttga acaactcatg
     1561 ggaagctgca gcctccggta cacggccaat agtagatgga gaaatcacgc attccacagg
     1621 ttctccatct ggatatttca atgtgcttga aatcaaatct gccacacttt tagccatgtt
     1681 cattgtttgc acttcaagtg attcgcgtac accttgacga cgaccatcaa tagtcggacg
     1741 aataccaata cgtggatgtt gaatcatact attttcctct tatttttctg tttctttcat
     1801 actaccatcg ccattatatt tacggtagcc tgggtgacga cctgtaacct tataattttc
     1861 tcgcattgag aatagacgtt ctaaagtcgg acgagcaatt tcttgctcct caatgccctt
     1921 tgtagaaagt aacattcttc cgtggaaggt tgtctttgcg actaattcta aagtttccat
     1981 acggtagtat gctgtaatta catcgcttcc gacagtcaga gctccatgat tttctaatag
     2041 catgacatca tgatcgggca gataaggtgt aattgcttct ggcacttcca ttgtagacgg
     2101 aactccaaat ggcgttatag gaattgctcc taccacaatc gcgctctcaa ttagtgaata
     2161 agtatctaaa ggaatgtgtg caagagcaaa tcctgttgca atcggtggat gcgcgtgaac
     2221 aactgaacgg acatcctcac gttcttcgta gcaccgaatg tgcattttaa tttcactaga
     2281 aggacagtaa tcaccttctg cttctaaaat ctctccttta agatttaact tcaccagctt
     2341 ttctggtgta ataaaacttt tgctgatacc agtaggtgtt gcaagaatgg tatcctcatc
     2401 taatcgaaca gatacattcc catcgttagc agcaacccaa ccaagttgcc acatcttatg
     2461 acaaacatca caaatctgtt cacgaattaa tttttcatct tgagacataa actcactcct
     2521 ttctaaaaat gaagttcgaa ttcaagattt ccgttactgt taatggtaat agtaaccata
     2581 tgatttttct gatcaaaatt gagagatggc tgatcatagg aattatttgt tcctgataat
     2641 gaatgaatag taggaagttt atctatacct cttaatacta tctttgtaac ccttttctct
     2701 ccaaactgag tatctttgat ataatgttct tcaatccact taatcgcacc tttcttggtc
     2761 aattgtggta gtttctttgc ctgatttgca tcttgagcat tagaccatag tgaatcttta
     2821 tttgttctaa aattatttaa attcactttc aatccattac ttattctctc aaaaatacca
     2881 taggtatgag gttcaaattc aacattcatt tctaaagaat taaattttaa tttcccagtc
     2941 tgtttaacat tctcatttac cttgtaatta tagacaaacc atctattatc taatttctga
     3001 gcaaagatat ctccttcata attcatagga tacagcttat ttaagtattc ttttctagcc
     3061 tgagtagagc taaattctgg agaagtgatt tccttaatct gaatacggct actagaaaca
     3121 gactctttca atttatctgt ttttaaaaca cctggaatag ctggaataac attataacga
     3181 ccagtcatgt ataatggagt ttgttctcta tcagtattta cgtttacaaa gaacttacca
     3241 tttcctttat ttgaatagtc tccatgtatg aatacttttg tatcctcaag taccttttct
     3301 ttggatggtg ctggatgcgc tattacatat ctaaaaaatt cttttattac ttcgctaaag
     3361 agtaagcttt ctttattatt tacaccatag gtataagctg ggtgttcaaa attataaact
     3421 acacctccat taaggtaaac ccctaaagct tcttctccta gcatagactc tggttcagtc
     3481 aaccattgtc tatctccttg actttttccg atattaccac ttgcaaacag tttccattta
     3541 cctgtctcat accacttcca agtatccatc aaaccacccc attgataagt atgatttgaa
     3601 agccaaagtc ccttcatata actttctgta gttgaatcat ttccctcagc agcaggtgta
     3661 tttttgaaca tgaaaataag gttcttccag tacttatcaa cagatttctg aaatgctatc
     3721 ttaccgtttt ttccaaatgc tttttctatt gcagaaccat tattttgttc agcccatata
     3781 aaatatcctc catttttagc tgatactttt aagtaatctg ccgccttatt ttcaatatca
     3841 tttgcccaaa tccaataatt ctctgtactg aaaataccat gcaaatttgg atatttttga
     3901 tacattttat caatccagct ggtacttaac caatgtgccg aagtataata aggcatatta
     3961 ccagcagtgt aaaccgtcag aataactgga attggttcat tttttccagt cttaggattt
     4021 acatatttcg ctgcttcttc taacatatgt tcataaaaat ctctagcagc tccatctctt
     4081 ttaggaagat catctggatg taactgtata acagtatatg gttttaagtc atctggtata
     4141 ttctcccact tacctgttaa tgtatctcct ccccaaaaag tatatttccc ttggttaaac
     4201 tcttctccgt tagcatataa aggcatcata agtaacggat gttcattatt aatttcacga
     4261 cgtttatcaa cttctgacca atcattagga ttcttaaatt taccatttgc cataaacaag
     4321 gctccaccta aaaccaattc gtcagcccat gtatgtttcc ctgaatatga tttaagttct
     4381 attgtctgtg tatctttggg aatttcaaca tcaaccagaa atgccgatgt atcatactta
     4441 attccttttg gatattttga atctgatgag taaatgactt taccatccgc aacaacttca
     4501 aatttttgaa tatctgcgta atctgaattt aaatgattgg cgctcctatc aattccgaca
     4561 taggaaataa atcttgtaac attagcaccc gaaacatcat attttatact agacgggttg
     4621 cttgctacag ttcccaatcc cttattaaat tcgacttcct taccgtcaat tagtaatttt
     4681 attttattat tagacccgtt attaccaggt gtaaacggtt tatctttctg aactgttttt
     4741 gatttatcgt catcaccatg agtagcatca acccattcta aatcagaaag atatactcct
     4801 ccattaattc ctttattaag aagatctgga gttatagttt gagtactaac agttttaata
     4861 agtttagcat cagcaaatac aacctcatca ccccatgtat gttctcctgc gaatgatttt
     4921 aaggatattt ttttagcgtt ttgtggaatt gtcacactaa taaattgtgc ctgggtatta
     4981 tatctgaatc cttctggatt agttacacta ctagaataga caacctttcc atcaatttct
     5041 atttctattc tatccactac tgcatggtct gatctagaac tattagcact ttgatcaatt
     5101 cctatataag tttcaaattt ttcaaaccct tgaccgctga tatcatagct gattactgat
     5161 ggagaatctg cgactgttcc tattccttta tcaaaatatt taactttatc atcagaagtg
     5221 agcaatgaaa tcttagtatg ctctccttta tttcctgttg taaatggagc atctttttgt
     5281 actgtttttg ttttatctat atcaccatga gttgcagaag accaatccat atctgaaaga
     5341 tatgtcatct ctttatcaat ttctttatct ttagtaataa gtttttctaa gttattccct
     5401 gttactctag cagtttcagt actagctctg ttattagaat tactttgaac tacatctgca
     5461 taaaccaaat tacttcctaa aaaacttgtt aaaacagccg tagctattaa aatctgtttt
     5521 gctatttttt tactttccat ttttatttcc tcaatattta catacaactt cttcaataac
     5581 aaataatttt gtaagatatt ctggaacaca aagtgctaaa ttacttaaac tgacttttat
     5641 tccagcattc attaattcat ctccataaaa gaactcatca aatctagaga cggaatagca
     5701 tttatcttta tctaaaccac taaaataaac tcttgtataa cctggattca acttactatt
     5761 caattgagca tacaataaaa tcgattggca tttatctttt gaaacaactt gccaactagc
     5821 agaatcacaa ctaaaaggac tgtttatcct atagaaatcc ccatattgaa acaatgaacg
     5881 atatttttta taaaactgaa tttgttctct cacttgttct ttttcttcta ccgacaatct
     5941 cgtaacatct aattcataac cgaaagaact aaaataagct acatttgtcc tagtgtccaa
     6001 actcgtttgt cttccacttt gttcatttgg agaaatagaa acatgggctg tcatcattga
     6061 tggagaatat ccataagaag ttccatgctg aattttcaat ctttctatcg ggtccgtatc
     6121 atcactcgtc cacgcttgcg gtgcataata cataagtcct aaatcaaaac gtccaccacc
     6181 tgaagaacaa gattcaaata gaactgaagg gaacttagtt attaaacgat ctaataactg
     6241 ataaagacct aagatatatc gatgaccaaa ttccatctgc tgttcagaat caagttcaat
     6301 actataaata tctgttatat gacgattcat atcccatttg atataatcca gatttgtttt
     6361 gattatgatt ttagaaatag aatcaaaaag gtaatcaaca acttcctgtc tcgtcaaatc
     6421 caacacatat tgatttcttc ctactgactt ctctctgtct aacaaatgga tagtccaatc
     6481 ggcatgattc ttgtacaaat cactatcaat agaaatcatt tcaggctcaa accacaaacc
     6541 aaattgtaaa cctattttgt gaatttcatc tgcaagaaat ccaatacctt caggaaggcg
     6601 acttctatct gttacccaat cccccagaga acttttgtca tctttcctat gaccaaacca
     6661 accatcatcc agtacaaata attctatccc taaatcttta gcagcctttg ctaaatctaa
     6721 aattttttct gtacccaagt caaaataaaa tgtttcccaa ctattgagta ttataggacg
     6781 actagcttga gaaaaattag gattaactaa atgatgtcga taaaaatctg atagttgttg
     6841 gctcatctga ttcatccctt gatcagaata gatcacaatt gcttctggtg tcacaaaact
     6901 ttcggcagga tttaataaaa aacgaaattc tactggattt attcctaccg ttactctagc
     6961 ggtgtcaaaa tggtcaactt caatcatatt ttgaaaattt ccagaataga taaagttaaa
     7021 accataaacc tcaccactat gctctgtagt ttccctcctt gatagcataa agaaaggatt
     7081 ttgctgagga cttgatgagt atctcaagct atctattgct tgaatacctg gtctaagcga
     7141 agttctatat aactgacgtt ccctcagcca tgctccagaa aattgaataa agtcatattg
     7201 actatcaggt agatctagct gtaagctcat tgctttcaaa agagtcaact tattattgct
     7261 attatttaaa aattccgtat ttctaactaa gacattgtat tccggaaaaa ttgtgtaatt
     7321 tagtctaaca gttaaatcta atatggaatc tgttaaaata atcgttaatg tttccgcaca
     7381 ctgaccaata tcatcaaatg ttgaaggtag agagttaaga cgatttttcc ctttttcaag
     7441 ttcaaaacct tgatatttta gtgtcgttat cctactacca ttcattcctt gaacttgaaa
     7501 ggctggatgc cgaaaatctc ctttcccata tgaagaatat tcattttgta tcatagactg
     7561 ttgaatatcc tcaaattctt cagaaaaaga tacttcaaat cctctttttt tataggccat
     7621 caattggtta taattttcct tgacatgaat ccttttccca aaatgtagat gttgaagttc
     7681 cccattttct aaaattctaa aaatataact actatctttc attgccaaat gaaaaacggt
     7741 ctcgtcctta ttaatataaa tcgtcatctc tacctcacaa ttttttcttt acttcttcag
     7801 tatcacgata gagtacggtg ccaattctat ctcatcttct tgaatagtaa aatctccaat
     7861 tactctggta aaattctcta tcgaaagatt ctctattttt attttttgtt taatctgagc
     7921 aggatttctc agagagagaa tttcagtaga agtcttctga ttgtgacact tataaccata
     7981 aatttcaaat ttttcaggac ttcctcctat tttttactat attttagtgt ttgataattc
     8041 tcctctatcc atttgacggc acgagcattg gctttccagc gctcttcatc aaacatatca
     8101 aaagaatagt gaaactccca aaaagcattc cctcttgttg aaataaataa tagataagct
     8161 tcaaaatctg gtattgatgc aaacatttga tgatccatgt accaggtatt tgcactgaca
     8221 gcatagattg gttcatgatt ataaagcgac cacataggta actgtatctc acgtttttcc
     8281 aaaaattctt gatactgact atctcggtaa gtaatcatac gattgatatc attacctgca
     8341 ttctctgtaa agcctacatc ttgagatatt tgaatccata aactattgac ccactgtaaa
     8401 aaccatggac taggatttac ataagaagtc aagtttaacc aacaatcttt tcctcctctc
     8461 tcctttctta gatctatcaa cagttgaatt aagaactcat aaaccgctgt catggtatac
     8521 ataccgtgcg gtccactctt atcaggtttg tcaggttgaa gtaaccaacc atcaattttc
     8581 caatagctga tatcgaattc tttttgatat tccaacatct ttttcttcat ttgattgaga
     8641 tagttaaaat cagccacgtt tacatcattt gaaatcaaat ttttagatcc aatatttaac
     8701 tctggatgtg cttctaacca atcactcata atgatttctg tcccattata accacctcgg
     8761 ggaccaatcc acaatcctag gcttgaacca aatccattta caagatattt aatatttctc
     8821 aaaccatttg ggaatttatg attgaattcc caaactgatt gatagtttgt ccaaccatca
     8881 tcaacaacat aagcatctaa atgaactcca tgattttcaa atccatctcg aatctcagaa
     8941 aaacttttta aaataccttc ctctgtaata tcggtcatat ggtcatacca ggaattatac
     9001 tgtttacgga aataactagg ttgagctatt ccttcaacat attcaaaaaa tgcctcttga
     9061 atctcttctt ttttataaga acatgctccc ccaataatac aagaccacaa actcttttct
     9121 tgatttacaa cagttcccaa gtaatatctt gatacatagt gtctaccatc taccttgttt
     9181 tcagacattg gaaattccat tcctaagaat aaagaattcg cataaacagg ttgtcccaat
     9241 tctacataat aaccggaaaa attcgccatt tccttaatac aatcttgtct tttcggatag
     9301 aaaatattgt cttctgtttc aaactcaaaa ctctctacct ctacagattt aataacctca
     9361 gtagatgatt ctaaaactaa ttgcttcgaa agaacatcat ccctcgattc aaagattaaa
     9421 cgtaaacgaa tggaaggaca aacaaaagaa acctgaattc gcgtatctcc ctcttcccta
     9481 acgattgctg aaaaatgagt ggaggaaagt ttaataccat tctccagtgt aatggtaaat
     9541 tcctctttcg aaacattttt tatcattact cctgcccgtt tgtttacgat atcagtagta
     9601 taaaatcgac cctctcccca aaagaaatta cgtcttacat ttttattttc aattttcata
     9661 taaactactc tctcaactca attttgatta cgctatcaat caagtctggt aatggatagg
     9721 taaaatgtgg aacttctcca aactgtgcaa aacaaattcc tttgtaggca ttggtcgtcc
     9781 agctttctga aattttcacc tcacttccat catgaagaaa gctcattctt tttacgtttt
     9841 ctttactaat accaagaaga gctaaaggac ctataggttg ttcaaataca tgagcataaa
     9901 ccgtatttcc attacgagta tagtatcccc aatctggttt tggtaaattt tcatctccac
     9961 tacatccata aattgcctca ccatttcgag acatccatcg atgaaaatta tctaatattt
    10021 tcttacttga atcattaatt cttcccaaag catctgggcc tacattaaga atcatatttc
    10081 cgtttttact aacacattcc actaactttc ttatcaaagt ttgactagac ttatatagat
    10141 aatctgtagg attataagcc caattgttat tcatagttag acaaagttcc caaggaacag
    10201 gttcaccttt aaagtttcga ataccttcgt gaggaacaat ttgctctgga ctaacaaaat
    10261 ctccagcgta agaggtaatt tcatctgtaa cgatacttcc gaatccttca cctgatgttt
    10321 ctaatctatt atctacgata acgtttggct gataatgacg aaccatgtct attaattttg
    10381 aagctcccca tttttcaccc accatgtctt cataagaata atcaaaccat aatatgtcaa
    10441 tctgaccata accagttaca atttctttaa cttgattgtg caaatactcc aaataactgt
    10501 caaagttaat tttctcatct cgatagactt catttcctct cattggatga tttagatcag
    10561 catatttagg gaaatcagga tggtgccagt caatcaaact aaaatataag cctactttta
    10621 aaccttcagc tcgaacagca tctacaaatt ctttaactaa atctctacct gcaggtgtat
    10681 ttgttgcttt ataatctgta aattttgaat caaacaaaca aaacccatca tgatgtttag
    10741 ccgttaaaac catatacttc atccctgcag cttttgcttg tttagcccat tctctagggt
    10801 tatattcctt aggatcaaaa gctcgaaaat atggttcata atcttcaata gataatttct
    10861 gatgactacg aatccattcc ccttttcctg gaatagaata taacccccca atgaatgaac
    10921 atcccaaatc ttgcttctct aaaccactga attctactat tgatagtttc aagtgtatgt
    10981 ttcatccttt tactgctcct cctcctaaag cttcaatgaa gtatttactt gtaaatgcga
    11041 atagaatgat tggtggtaat acgattacaa caatagctga aaatagacca ttataattag
    11101 tattaaaact tgtagtaaat tgacctagta atgctggtac tgttaattca tttttatcaa
    11161 tcaccaacat agatgcccaa taatattcat tccagttatt aataaaggca agtactgctg
    11221 ctgttaaaat tcctggtcta gcaattggca acatcacttt ccaaaaagtt tgagcatatg
    11281 tcgcaccatc aatctctgct gcctcctcca attcttttgg aataatttca aaatagttct
    11341 ttataataaa gaaactcata gcaattccac tacaagaata gaccagaatt agagcaactg
    11401 gggtattata aatccccaac tcatttacta atctataaac tggaaaagtc atagctgttg
    11461 ctggaataaa tagagtagaa tacagcatag aagtcaccaa cttcttccct ctaaattcca
    11521 tcctagcaat aacatatgaa gacatggaga tcataacaat gctaataata actgatatag
    11581 acactacttt aaagctattc caaaagtaag taaaaacatg aagttttgta aaaacattta
    11641 tataaccttc aagagtaaag tcagtcggta aactaatacc tggatttttc ataggatctg
    11701 cttttaatga tgataaaaaa atccacgcaa tagggaaaat agaaattaaa atggtaagga
    11761 gcatataacc atatataaga actttgcctt ttttactaat accatttata tgtgtattca
    11821 taatcatttc tcacctttca gtctttttct ttctctgaat aaaatattaa tacaaacgat
    11881 aatcaacatt ccacctaaga tttgtataac tccaattgta tttgcacgag catactgagt
    11941 tcgtgagcta gccactgcta attctcgaat aacaaaactg atactttttg ttcctgcagc
    12001 accatttgtc aaaaagaata cttcgttata gagcaaaaat cctgaagttg ctgccataat
    12061 tgaaacagtt ttaattgtcc ccttaatcat cggaatcgta atataccact ctttcctcca
    12121 accagtaata ttgtctaaaa tagcagcttc ttgaacttct tctggaatag caaaaatttg
    12181 cccaagaatc ataatggttg atgctcctgc aaagaagata taagcgccag tcatagctac
    12241 tatatttaat cctggagtca acagtactga atctttaaac gatggattaa atagatgaat
    12301 aatttggtta acaacaccat agtttggatt atagatttga agaaaaatca agcccatagc
    12361 agcactagaa atgatacttg gtacaatata aagattccta gatatcttcc agccttttaa
    12421 tttcttagat aatgtaattg caacagatac agctaaagga acttgaataa taacaccaat
    12481 tacagcccaa cgaacagaat taattagagc ttctgtaaaa aatgggtatt ctttaaaaac
    12541 atacctataa ttttcaaata atttatcaaa tccaagaaac tcaggggtgt ttaaatttgt
    12601 ataatcccat ttagcaaatg aagttaaaaa gattgttact acagaataaa aataaaatag
    12661 aaagaaacaa atcaacgttg gcaaaagaaa taaaaagata aatcgtcttt tttgattctt
    12721 cctattttgt aggctcataa ttttttgtgc cataaacaaa ctcctttttt caactatata
    12781 agtaaaatca agctcagttg gcagtgccaa ctgagcttcg ttttcactcc ctaaaacaat
    12841 taaccaatca atgatttcaa cacatcttga gtagatttta ctttttgatc aacatctaca
    12901 ttttcagcag cactttctgt caatgcattg ataatagctg tgtgtacatc gccaccccaa
    12961 acatcactta cagttggaac aactgctttt gcattcttaa cttgagtgat tgcttgtcct
    13021 aaaattttag tagtagcttc tgaactcttt tctgaaagtt cttttacatt tacattttca
    13081 ttagaaggat ttgctcctac tttttcaaaa attacttttt gtacatcatc gctagtcata
    13141 tatttcaaaa actcaagagc tagtttttgt ttagcttcag acatcttact tgagatagtg
    13201 ataccacctc cagaagaact aattgctaca cctgcaggat agattccagg tgcaagactt
    13261 gggttcttag acatctcacc agaagcccac acaccattaa agaatactgc agatttacct
    13321 tcttggaaat ctttggaata agcattggca tcgccaccag cattcttaga accattagct
    13381 tgaatttctt tcataaccat tttcaaagca tctgcaaatt ctttagattc aattccttct
    13441 tttgttaatg gtttatctaa taatttacgt ccattttctg tggttcctaa tactgtatta
    13501 aacaagcgaa tagatggttc tccagcacca aatgcataca ctccatcttg ttttctaatg
    13561 cttgccattg cctgagtgaa atcatcccaa gtattccact gatcaggtgt cttagcaccc
    13621 gcttttgcaa atatgtcctt gttgtaccac aaacccattg taaataactg ttcgtgaact
    13681 gtataaattt ttccatcttt ttggttttgc ttatagttca aaccaacatt tttttcaagc
    13741 ttatttgaat cgatatatgg tttcaaatct aaaacaagtt tttgttcaat cgcagctaat
    13801 gatactgcat tacctgctag gtcaatcaca tcaggaaatt caccactagc aaccttgtta
    13861 ttcattatat ccttcaaatc accatttaca ggagttggtt taaattctac accactatct
    13921 ttatgttctt ctgcaaattt atcatataaa tctcgcatag tcttcgctac aggccattca
    13981 tcttcactat gatgataccc atgataaaat tctaatactt ctttaccaga agaacttcca
    14041 ccgcttgcat ccttagatgt tccacaagct gctaaaccaa aggtagctac taacccgata
    14101 acagcgcatt tcaaaagact ttttttgttc atgacaaaac ctccgttttt ttatttttgt
    14161 ttatgatagc tgaggataat aatattttgt atcagcaata tttgtcataa tatcctttaa
    14221 ctctgtatcc tcgtttattt taccttgact caatagctgc acaacaatat tccccacagc
    14281 tgtaccctca gtcgaacctg taagaacctc tttaccagtt ctatcagcaa tcatttggtt
    14341 aaagtaactg gctctagcac ctcctccaat cacatatatc ctcttataaa ccttatgagt
    14401 tagttcttct agtaactcta tcgctttcct atacgtttca gctaggcttt cataaacaat
    14461 cttaaatagt tgtccatctg tccactctct agtttcatga tgataagcta gatattctgt
    14521 caaagtcttg tgcatatcag attctgttgc aaattcagtt gattcagtat caatcagagg
    14581 aagattttct ttttctttct ccaccattgt cctaatatca tcaaaagaat aggctttccc
    14641 tcttcgttca aatgaacgtc ttagttcctc tatgatccac aaccctgtac aattcttcag
    14701 aaatgtaatc actccatctt taccgacttc atttgtaaat ccataactga aggattcggt
    14761 agtaagaatc ggtgaagtaa gttccactcc aaccaaagac caagtacctg atgaaataaa
    14821 taaactacct tctgtcttag gtactgagac aatcgcactt gctgtatcat gactacaaac
    14881 attcacaaca ggaatatcgc ctaaaccata ctcctctttt atccttccaa gaacatttcc
    14941 ctctgaaaca atttcaggaa gtaaagataa atccaattca aatagtttta agatattctg
    15001 attccaattt tgactcctag gatcaaataa ttgagttgtt gaagcaatgc ttttttctgt
    15061 agcaaactta cctgtcaaga gataattaaa caaatctggc attaaaagaa tcttattggt
    15121 cttatagaaa gagtcaggag attcttgacg tgccttaaag agttgaaaca aggtatttat
    15181 ctccataatc tgatttcctg tctctgaata cagtttttct aattcagtca tttcagatat
    15241 ttcctttaac actccctttg ttctttcatc acgataatga acaggttgtg ataacagctt
    15301 accttcatta tcaatcagtc caaaatcaac tccccatgtg tcaataccga tagataaaat
    15361 cttgtaacta gtattagcca agcggatact ttcaagaatt ttagctagta gaaagtcaat
    15421 atcccaagat aaatgccctt ttactctaat aggtagatta gaaaagcgat ttatttcttc
    15481 cattactagt ttattttcag aaaggtaacc aacgattgct cttccagaag tcgcacctaa
    15541 atctattgct aaaaccgctt ccatttttct tctctcttcg tccttgatta agtttattat
    15601 aatccccaca ttttattttt tcaatatgtg aacgcttact tggataatgt tcaaatgtta
    15661 acccaatatt cataaaaata attcaaattc ctccaatttg tgctataata tagttgaaat
    15721 gataaattag gaggagctta tgataaaaga tgaacgtgta cttgaattga ttgaaatcat
    15781 caaaaagaaa aaaagaattg ccgtaaaaga gctggcagaa atcactttct ccagcacaag
    15841 taccttacgt cgtgatttaa ttttcttaga aaatcaaggt cttatcaaaa gaaagcacgg
    15901 atacgtgacc ctgtcctcta tgaacacaat tgaactttct catcaaatac gggaaggaga
    15961 aagtactagg caaaaaagac taatcgctag tctcgctaaa gactttattc ggtctggtat
    16021 gtgtatctat ctagattcca gtacgactgt ctacgaactt tgtccctatc tttctgaact
    16081 tgataatttg attattttta caaatggttt acatactgca caaaccctat ctgaaactgt
    16141 taaagatagc tccaaaatct ttatcacatc tggcgaggtc aaacatcaat cctgttccgt
    16201 ggtcaactat gataaggaaa attctttatt agatcatttt aatatcgatt tagcattttg
    16261 ttcagcaaga ggtattgatg accaatatgt ttatgaagct tctctcagcc aagctatttc
    16321 aaaaaagaat attattgaca aagcccatga aaccatctta ctgattgata gttctaaatt
    16381 ttacaagact ggatttttta aaattaatcc cctctccaaa tacacaacct ttatttctga
    16441 caccgtgcca gaccaaaaat tattagacgc agtcgaatta tttgatggag aatga
//
