LOCUS       AE005672               13366 bp    DNA     linear   BCT 31-JAN-2014
DEFINITION  Streptococcus pneumoniae TIGR4, complete genome.
ACCESSION   AE005672
VERSION     AE005672.3
DBLINK      BioProject: PRJNA277
            BioSample: SAMN02604002
KEYWORDS    .
SOURCE      Streptococcus pneumoniae TIGR4
  ORGANISM  Streptococcus pneumoniae TIGR4
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13366)
  AUTHORS   Tettelin,H., Nelson,K.E., Paulsen,I.T., Eisen,J.A., Read,T.D.,
            Peterson,S., Heidelberg,J., DeBoy,R.T., Haft,D.H., Dodson,R.J.,
            Durkin,A.S., Gwinn,M., Kolonay,J.F., Nelson,W.C., Peterson,J.D.,
            Umayam,L.A., White,O., Salzberg,S.L., Lewis,M.R., Radune,D.,
            Holtzapple,E., Khouri,H., Wolf,A.M., Utterback,T.R., Hansen,C.L.,
            McDonald,L.A., Feldblyum,T.V., Angiuoli,S., Dickinson,T.,
            Hickey,E.K., Holt,I.E., Loftus,B.J., Yang,F., Smith,H.O.,
            Venter,J.C., Dougherty,B.A., Morrison,D.A., Hollingshead,S.K. and
            Fraser,C.M.
  TITLE     Complete genome sequence of a virulent isolate of Streptococcus
            pneumoniae
  JOURNAL   Science 293 (5529), 498-506 (2001)
   PUBMED   11463916
REFERENCE   2  (bases 1 to 13366)
  AUTHORS   Tettelin,H., Nelson,K.E., Paulsen,I.T., Eisen,J.A., Read,T.D.,
            Peterson,S., Heidelberg,J., DeBoy,R.T., Haft,D.H., Dodson,R.J.,
            Durkin,A.S., Gwinn,M., Kolonay,J.F., Nelson,W.C., Peterson,J.D.,
            Umayam,L.A., White,O., Lewis,M.R., Radune,D., Holtzapple,E.,
            Khouri,H., Wolf,A.M., Utterback,T.R., Hansen,C.L., McDonald,L.A.,
            Feldblyum,T.V., Angiuoli,S., Gesuwan,P., Hickey,E.K., Holt,I.E.,
            Loftus,B.J., Ujwal,M.L., Yang,F., Smith,H.O., Venter,J.C.,
            Dougherty,B.A., Morrison,D.A., Hollingshead,S.K. and Fraser,C.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUN-2001) The Institute for Genomic Research, 9712
            Medical Center Dr, Rockville, MD 20850, USA
REFERENCE   3  (bases 1 to 13366)
  AUTHORS   Shumway,M., Schobel,S., Koo,H., Dodson,R. and Tettelin,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2006) The Institute for Genomic Research, 9712
            Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Sequence update by submitter
REFERENCE   4  (bases 1 to 13366)
  AUTHORS   Tettelin,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JUL-2008) Institute for Genome Sciences, Department of
            Microbiology and Immunology, University of Maryland School of
            Medicine, HSF-II, Room S245, 20 Penn Street, Rockville, MD 21201,
            USA
  REMARK    Sequence update by submitter
COMMENT     On Jul 3, 2008 this sequence version replaced AE005672.2.
FEATURES             Location/Qualifiers
     source          1..13366
                     /organism="Streptococcus pneumoniae TIGR4"
                     /mol_type="genomic DNA"
                     /strain="TIGR4; ATCC BAA-334"
                     /db_xref="ATCC:BAA-334"
                     /db_xref="taxon:170187"
     gene            complement(1..1767)
                     /gene="fucI"
                     /locus_tag="SP_2158"
     CDS             complement(1..1767)
                     /gene="fucI"
                     /locus_tag="SP_2158"
                     /EC_number="5.3.1.25"
                     /note="identified by similarity to EGAD:7389; match to
                     protein family HMM PF02952; match to protein family HMM
                     PF07881; match to protein family HMM PF07882; match to
                     protein family HMM TIGR01089"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="AAK76212.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKY
                     PDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHA
                     IWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEASDTDIPEDVKEKLLRYARA
                     ALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDP
                     EEFERALKWVKENVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNPRLAEL
                     GFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLN
                     GVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSGSCTLDGT
                     GQATRDGKPIMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMV
                     RLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDV
                     MNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESAD
                     YRACQLLGPLHK"
     gene            complement(1850..4966)
                     /locus_tag="SP_2159"
     CDS             complement(1850..4966)
                     /locus_tag="SP_2159"
                     /note="identified by similarity to GP:9651025; match to
                     protein family HMM PF00754"
                     /codon_start=1
                     /transl_table=11
                     /product="GH98|CBM47"
                     /protein_id="AAK76213.1"
                     /translation="MNKEKIKRKLITILFVCIGMLCFGLLAGVKADNRVQMRTTINNES
                     PLLLSPLYGNDNGNGLWWGNTLKGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDTKE
                     LREWYVKMLEEAQSLNIPVFLVIMSAGERNTVPPEWLDEQFQKYSVLKGVLNIENYWIY
                     NNQLAPHSAKYLEVCAKYGAHFIWHDHEKWFWETIMNDPTFFEASQKYHKNLVLATKNT
                     PIRDDAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFETGRARDMRSYASEPES
                     MIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPTPAFTKGIIPFFRHAIQNPAPSKEEVV
                     NRTKAVFWNGEGRISSLNGFYQGLYSNDETMPLYNNGRYHILPVIHEKIDKEKISSIFP
                     NAKILTKNSEELSSKVNYLNSLYPKLYEGDGYAQRVGNSWYIYNSNANINKNQQVMLPM
                     YTNNTKSLSLDLTPHTYAVVKENPNNLHILLNNYRTDKTAMWALSGNFDASKSWKKEEL
                     ELANWISKNYSINPVDNDFRTTTLTLKGHTGHKPQINISGDKNHYTYTENWDENTHVYT
                     ITVNHNGMVEMSINTEGTGPVSFPTPDKFNDGNLNIAYAKPTTQSSVDYNGDPNRAVDG
                     NRNGNFNSGSVTHTRADNPSWWEVDLKKMDKVGLVKIYNRTDAETQRLSNFDVILYDNN
                     RNEVAKKHVNNLSGESVSLDFKEKGARYIKVKLLTSGVPLSLAEVEVFRESDGKQSEED
                     IDKITEDKVVSTNKVATQSSTNYEGVAALAVDGNKDGDYGHHSVTHTKADSNAWWQVDL
                     GEEFTVSKVDIYNRTDAEPQRLSNFDVIFLSSSGEEVFRRHFDKVVDGLLSLKVPSVGA
                     KLVKIELKSAAIPLSLAEVEVYGSKRTPKKLSNIALTKETRQSSTDYNGFSRLAVDGNK
                     NGDYGHHSVTHTKEDSPSWWEIDLAQTEELEKLIIYNRTDAEIQRLSNFDIIIYDSNDY
                     EVFTQHIDSLESNNLSIDLKGLKGKKVRISLRSAGIPLSLAEVEVYTYK"
     gene            complement(4976..7270)
                     /locus_tag="SP_2160"
     CDS             complement(4976..7270)
                     /locus_tag="SP_2160"
                     /note="identified by similarity to GP:4455171"
                     /codon_start=1
                     /transl_table=11
                     /product="GH95"
                     /protein_id="AAK76214.1"
                     /translation="MKLWYKKAAANWNEALPIGNGHLGGMIYGSATKECIQLNDETIWY
                     RGKSDRNNPDSLLHLKKIREYLLDGEIQKAEELIKLTVFATPRDQSHYELLGELYIEHI
                     DIQSCALSLYERELDLDTAISNVVFEPNSCNLQIKREYFTSFNKNILCCRIVSSVQNTL
                     NLNINLGRNKRFNDEVSKLDSSTILMSASAGGRKGVQFKVVCHSKVTDGEVSVLGETIV
                     IRNATEVFLYLKSMTDYWGNIDISSLQGEFSSIDYFTEKDEHVKKYQEQFNRVDFKLDY
                     SKGCLSIPTNLLLENTKKYSNYLTNLLFHYGRYLLISSSQPNGLPANLQGIWCDELNPI
                     WGSKYTININTQMNYWMVGPCDLPEVEYPLFDMLERMREPGRLTAKKMYGARGFTAHHN
                     TDGFGDTAPQSHAMGAAIWVLTIPWLCTHIWEHYLYFQDERILTEHFEMIKEAFLFFED
                     YLFEVDGYLMTGPSVSPENKYRLKNGIEGNACLSSTIDNQILRYFCDSCIGIAKQLGDN
                     SDFISRVKELKKKLPKTKIGSNGQIQEWLEDYEEVEPGHRHISPLFGLYPYNEIDIHKT
                     PELAEAAKITINRRLSNANFLSSQEREQAINNWLVSGLHASTQTGWSAAWLIHFFARLY
                     QGEPAYNQINGLLNNATLGNLFLDHPPFQIDGNLGLVSGICELLVQSHHNWLSLIPALP
                     SAWSEGEVKGFRVRGGYKVSFAWKNGDITFLKLEGGNKDQKVRVRIYGKNTDVQNIELV
                     FNSEKIIELNF"
     gene            complement(7329..8129)
                     /locus_tag="SP_2161"
     CDS             complement(7329..8129)
                     /locus_tag="SP_2161"
                     /note="identified by similarity to EGAD:91568; match to
                     protein family HMM PF03613"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q97N94|4.A.6.1.9"
                     /protein_id="AAK76215.1"
                     /translation="MMNNKVTKVELKKVFKRSFMYGSSWNYERMQNLGFLYTILPVLKK
                     LYPDKDSASPAMKRHLEFFNTHQTAAPFILGVTSAMEEQEGNEGAASITGIKVGLMGPL
                     AGLGDSLFWLTLVPICFSIGASYSKDGGALGIFIALILFNIINIPVKYFGLKYGYTKGS
                     SLIQENNTKGTLNRVTSMATALGLVLVGGLIPSMVGINFGLEFKQGELVISVQEMITKL
                     IPGFIPMALTLLMCKLIRKGKNPVVLIFSVMAIGVILVVLGILK"
     gene            complement(8126..8899)
                     /locus_tag="SP_2162"
     CDS             complement(8126..8899)
                     /locus_tag="SP_2162"
                     /note="identified by similarity to EGAD:14386; match to
                     protein family HMM PF03609"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q97N93|4.A.6.1.9"
                     /protein_id="AAK76216.1"
                     /translation="MLFTQALLVTLVGIIATIDYNGPLFMIHRPLVTSAMVGLVLGDFT
                     QGVLIGSALELTWLGVTGIGGYTPPDTISGAIIGTAFGILSGQGETAGIAIAVPIAVAT
                     QQLDVLAKTLDVYFVKKADNDAKNGDYSKIGFYHYSSLVLITLFKIVPIFLAIMLGGEY
                     VADLFAKVPPIVMQGLNSAGALLPSIGFGMLLNMMLKKNMWVFLLIGFICSVYGGMSTI
                     GISLVGIAVAYFYDMIGSKPQETTSSSDVEEDLDL"
     gene            complement(8924..9394)
                     /locus_tag="SP_2163"
     CDS             complement(8924..9394)
                     /locus_tag="SP_2163"
                     /note="identified by similarity to OMNI:NT01BS3148; match
                     to protein family HMM PF03830"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q97N92|4.A.6.1.9"
                     /protein_id="AAK76217.1"
                     /translation="MSIEFVRIDDRLVHGQVVTTWLKKYDIEQVIIVNDRISEDKTRQS
                     ILKISAPVGLKIVFFSVKRFVEVLNSVPIKKRTMLIYTNPKDVYDSIEGNLKLEYLNVG
                     QMSKTEENEKVTGGVALGEEDKYYFKKIVDKGTRVEIQMVPNDKVTMLEKFL"
     gene            complement(9385..9816)
                     /locus_tag="SP_2164"
     CDS             complement(9385..9816)
                     /locus_tag="SP_2164"
                     /note="identified by similarity to EGAD:7066; match to
                     protein family HMM PF03610"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q97N91|4.A.6.1.9"
                     /protein_id="AAK76218.1"
                     /translation="MFNRGILVASHGNFASGALMTAEMFVGETTNDRVRTLGLMPGENI
                     VEFEHYFKNQVDELLDSNQEVIVLTDLIGGSPNNVALSRFLNLDSVDIVTGFNIPLLVE
                     LISSYDSKINLEEIVHNAQNSLFNVKQQLNVEEEEDLCL"
     gene            complement(9806..10249)
                     /gene="fucU"
                     /locus_tag="SP_2165"
     CDS             complement(9806..10249)
                     /gene="fucU"
                     /locus_tag="SP_2165"
                     /note="identified by match to protein family HMM PF05025"
                     /codon_start=1
                     /transl_table=11
                     /product="fucose operon FucU protein"
                     /protein_id="AAK76219.1"
                     /translation="MLKHIPKNISPDLLKTLMEMGHGDEIVLADANYPSASCANKLIRC
                     DGVNIPELLDSILYLMPLDSYVDSSIQFMNVVSGDDIPKIWGTYRQMIEGHGTDLKTIT
                     YLRREDFYERSKKAYAIVATGETSLYANIILKKGVVVERENVQ"
     gene            complement(10261..10899)
                     /gene="fucA"
                     /locus_tag="SP_2166"
     CDS             complement(10261..10899)
                     /gene="fucA"
                     /locus_tag="SP_2166"
                     /EC_number="4.1.2.17"
                     /note="identified by similarity to EGAD:14625; match to
                     protein family HMM PF00596"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose phosphate aldolase"
                     /protein_id="AAK76220.1"
                     /translation="MSDVKQELIKYGKKLVETDLTKGTGGNLSVFDREKQLMAITPSGI
                     DFFEIKESDIVVMDINGNVVEGERLPSSEWYMHLIQYQTRDDIDAIIHAHTTYATVLAC
                     LREPLPASHYMIAVAGKDVRVAEYATYGTKELAVNAAKAMEGRRAVLLANHGILAGAQN
                     LLNAFNIVEEVEYCAKIYCLAKNFGEPVVLPDEEMELMAEKFKTYGQRK"
     gene            complement(11014..12417)
                     /locus_tag="SP_2167"
     CDS             complement(11014..12417)
                     /locus_tag="SP_2167"
                     /EC_number="2.7.1.51"
                     /note="identified by similarity to GP:6015983; match to
                     protein family HMM PF00370"
                     /codon_start=1
                     /transl_table=11
                     /product="putative L-fuculose kinase fucK"
                     /protein_id="AAK76221.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGHL
                     SWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLLQPVHYRDERTKG
                     VLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFNYLL
                     TGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKEEYGLG
                     DIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGFTNEVG
                     KDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTESTEFAT
                     ESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKVYKRIYVI
                     GGGARASYFNQMIADRTGKEVLTGLTEATAVGNIVVQLIAMGQLKGMEEAHHVIEEFLQ
                     LESYYSQKN"
     gene            12593..13366
                     /locus_tag="SP_2168"
     CDS             12593..13366
                     /locus_tag="SP_2168"
                     /note="identified by match to protein family HMM PF00455;
                     match to protein family HMM PF08220"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_DeoR,DBD-SUPERFAMILY|0043758"
                     /protein_id="AAK76222.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLEN
                     QGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCIYLDSSTTV
                     YELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKENSL
                     LDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTGFFKI
                     NPLSKYTTFISDTVPDQKLLDAVELFDGEWVSDIQ"
ORIGIN
        1 ttatttatgt agtggcccca acaactgaca tgcacgatag tctgctgatt ctagatcttc
       61 tgttccaaat aaggaccaat ttttaggtct aaagatatct tcctcaggta cattatgcat
      121 attgacagga attctcaaca tagaagccaa ggtaatcaag tctgctccaa tgtgtccata
      181 tgttatggct ccgtgattag ctccccaatt attcatgacg tcatagacag acttgaaagc
      241 accttttcct gtcaaacgtg gagcaaacca agtagttggc catcctggat ctgtacgatt
      301 atctaaagta tggtgaacat cttcaggaag ttcaagtgtg taaccttctg caatttgtag
      361 cactggacca acccctttta gaagattgag acgtaccatt gttactggca tatccccctt
      421 cgtcaagaaa cgagttgaga atcctcctcc acggaagtat tcgcggtttg ctggtgggaa
      481 gtctgtattt tcaagcatag cctgcacttc actttcttcc aactcccaga atggtttcat
      541 aataggtttg ccatctcgag tagcttgacc tgtaccatcc aatgtacaag aaccagagtt
      601 gattagatgt aagaagccag ctgcagcacg accctctaaa gtatgtcccg ttacacgttt
      661 aacagcctct gggctccaat aagtacgcac atcagcaaag atttgtggag tatttgttaa
      721 tagataatta aagagcatag acacaccatt tagtgaatca ttctctgtcg caaatacaaa
      781 tggttttcga ataccattcc agtcaaactg agtattgagg aaagtttcca taaagtcccc
      841 atttggaaaa tggtctgtcc actgacgttg accttggaaa ccagctacta aagcatggtg
      901 accaaccgct tcttcctcaa aaccaagttc agcaagtctt gggttaccaa ccattaagtc
      961 acgtccaatc atgaacatct taataacaaa ttcccattgt ctatcttttt cttcacggct
     1021 taaaacaagg tcttcacggt tatggtcgaa tccttctttt acgttttctt tcacccattt
     1081 gagcgcacgt tcgaactctt cagggtcgta aataccacgg tccatacggc gcgtgaactc
     1141 cgtcatatct accgattcat ttcgcattcc taagtattct tggaagaaat ccggatttac
     1201 aatagaacca ccaatcccca tcgaaacact acccattgat aggtaagcag tgtctctcat
     1261 caagccagtt gcaagagctg cacgcgcata gcgtaaaagt ttttctttga catcttctgg
     1321 aatatctgtg tcactagctt cctgaacatc tcttccataa atcccaaagg ctggaatccc
     1381 tttttgagca tgtgaagcta gtacagctgc aagatagaca gctcctgggc gttctgtccc
     1441 attaaatccc caaatagcat gaggaatatc tggagacata tccatagttt cactaccata
     1501 acaccagcat ggtgtaactg taattgttgc gcaaacattt gattttttaa acaactcatg
     1561 ggaagctgca gcctctggta cacggccaat agtagatgga gaaatcacgc attccacagg
     1621 ttccccatct ggatatttca atgtgcttga aatcaaatct gccacacttt tagccatgtt
     1681 cattgtttgc acttcaagtg attcgcgtac accttgacga cgaccatcaa tagtcggacg
     1741 aatcccaata cgtggatgtt gaatcatact attttcctct tatttttctg tttctttcat
     1801 actaccatct ccattatatt tacggtagcc tgggtgataa tttttaaaat tacttataag
     1861 tataaacctc tacctctgct aaacttaaag gaattcctgc gcttctcaaa gaaattctaa
     1921 ccttttttcc cttcagtcct tttaagtcta tggatagatt attgctttct aaactgtcaa
     1981 tatgttgtgt aaaaacttca taatcatttg aatcatatat aataatatca aaatttgata
     2041 atctctgaat ttcagcatct gttctattat aaataattaa cttttctaat tcttcggttt
     2101 gtgctaaatc tatctcccac catgaaggag aatcttcttt ggtatgagtc actgaatgat
     2161 gaccataatc tccgttttta tttccatcaa ctgctagacg agaaaaacca ttgtaatccg
     2221 ttgaactctg tcgagtttct tttgttaatg caatattaga aagtttcttc ggagttctct
     2281 ttgaaccata gacttcaact tccgctaaac ttaacggaat agctgctgat tttaattcta
     2341 ttttgactag cttagcccct acagaaggta cttttaaaga taacaaacca tcaactactt
     2401 tatcaaaatg tcttctaaaa acttcttctc ctgatgaaga tagaaaaata acatcaaaat
     2461 tagataaacg ctgaggttcg gcatctgttc tattataaat atcaacttta gaaaccgtaa
     2521 actcttctcc cagatcgacc tgccaccaag cgttagaatc tgccttagta tgagtcaccg
     2581 aatgatgtcc gtaatctcca tctttattac catcaactgc taaagcagct acaccctcat
     2641 aattggttga actttgagta gctaccttat ttgtagagac tactttatct tctgttattt
     2701 tatctatatc ctcttcagat tgcttaccat ctgattctct aaaaacctct acttctgcta
     2761 aactcaaagg cactccactc gttagtaatt taactttaat ataccttgct cctttttctt
     2821 tgaaatctag actaacagat tcacccgaca aattattaac atgtttctta gcaacttcgt
     2881 ttctattatt gtcatataga atcacatcaa aattagatag acgttgagtc tcagcatctg
     2941 tgcgattata aattttaaca agcccaactt tatccatttt tttcaaatcg acttcccacc
     3001 aagagggatt atctgcccta gtgtgtgtta ccgaaccaga gttaaaatta ccatttctgt
     3061 taccatccac agctctatta gggtctccat tgtaatctac agaactttgt gttgttggtt
     3121 ttgcatatgc tatattcaaa ttaccatcat taaatttatc tggtgttggg aaagagactg
     3181 gacctgtccc ctcagtattt atagacatct ctaccattcc attatgatta accgtaatgg
     3241 tataaacatg ggtattctca tcccaatttt ctgtataagt ataatgattt ttatcgccac
     3301 ttatatttat ctgaggttta tgaccagtat gcccttttaa tgtaagtgtt gttgtcctaa
     3361 agtcattatc tacaggattg atggaataat ttttgcttat ccagttcgct aactctaatt
     3421 cttctttctt ccaacttttt gatgcatcaa aatttcctga taatgcccac atagctgtct
     3481 tatctgtcct gtaattattc aataaaatat gtaaattatt tggattttct ttaacaacag
     3541 cgtaagtatg tggcgtcaaa tctaacgata acgactttgt attattagta tacataggca
     3601 acattacttg ctgattttta ttgatattag cattactatt ataaatatac caggaattac
     3661 ctacacgctg agcataccca tctccttcat aaagttttgg ataaagcgag tttaaatagt
     3721 tgactttact agacaattcc tcactatttt tagtcaaaat ttttgcatta gggaatatag
     3781 atgaaatctt ttccttatca attttctcat gtattacagg aagaatatga tatctcccat
     3841 tattatataa aggcattgtt tcatcattcg aataaagtcc ttgataaaat ccgtttaatg
     3901 aactaatcct accttctcca ttccaaaata cagcttttgt tctatttaca acttcttcct
     3961 tacttggagc tggattttgt atagcatgtc taaagaaagg aataatacct ttagtaaatg
     4021 ctggagttgg tacatcattt gtcataaatg tatacgcggc acattcgaaa ttataaactg
     4081 tgcctccccc agtatataca ttcatcattt ccatagcaat cattgattct ggttccgatg
     4141 cataggatct catatcccta gctcttccag tttcaaatgt gtttgtataa tgtttttccc
     4201 accatttcca tgtatctgtt gatgagcccc agttatcaca taagccactc aaccaaaatc
     4261 cactaacgat agaatctgta cccgcatcat ctcttattgg cgtattttta gttgccaaca
     4321 ccaaattttt atgatatttt tgactcgctt caaagaatgt cggatcattc ataatagttt
     4381 cccagaacca tttttcatga tcatgccaga taaaatgcgc tccatatttg gcacaaactt
     4441 ccaaatattt agcactatgc ggagctaact ggttattgta aatccaataa ttctcaatat
     4501 ttaaaacacc ttttaacaca ctatactttt ggaattgttc atctaaccac tctggaggaa
     4561 ctgtattacg ctctccagcc gacataataa ccaagaaaac tggaatgttt agactttgag
     4621 cttcctccaa catcttgaca taccattctc tcaattcttt cgtatctcgt ggaatacaac
     4681 ttgttggttt acagactttt gcaggatgaa gttcaatcgc tgcatatggc tttacatctt
     4741 caggaatagc ttcccatgct cccttcaatg tgttccccca ccataatccg ttaccattat
     4801 cattgccata caacggagaa agcaacaatg gcgattcatt attaatcgtc gttctcattt
     4861 gaacacgatt atcagcctta actcctgcta acaatccaaa acataacatc ccaatacata
     4921 caaacaatat tgtgattaat tttcttttta ttttttcttt attcatgact tatacctaaa
     4981 aatttaactc aataattttt tctgaattaa ataccaattc aatattttgt acatcagtat
     5041 ttttgccata tattcttact cttacttttt gatctttgtt tcctccttcc aattttagga
     5101 atgttatatc cccatttttc caagcaaacg ataccttata tcctcctctt actctgaaac
     5161 ctttcacttc tccttctgac caagcagaag gtaaagctgg aattagtgat aaccaattat
     5221 gatggctctg tactaataat tcacaaattc cactcaccaa acctaaatta ccatcaattt
     5281 gaaatggtgg atggtcaaga aataaattgc caagagtcgc attatttaac aaaccattaa
     5341 tctggttata agcaggttca ccttgatata gtctcgcaaa aaaatgaatc agccatgcag
     5401 cactccaacc tgtttgtgta ctagcatgca aaccacttac taaccaatta ttaatcgctt
     5461 gctccctctc ctgtgaagat aaaaaattag cgtttgataa tctcctattg atagtgattt
     5521 tagctgcttc tgctaattcc ggagttttat gaatatcaat ctcattataa ggataaagcc
     5581 caaatagagg tgaaatgtgt ctatgcccag gctctacttc ttcataatct tctaaccatt
     5641 cttggatttg cccattacta cctatttttg ttttaggtag tttctttttt aactccttca
     5701 cacgactaat aaaatccgaa ttgtctccta attgttttgc aatgccaatg catgaatcac
     5761 aaaaatatct tagaatttga ttatcaattg tagatgatag acaagcattt ccttcaatac
     5821 cattttttaa gcgatattta ttttccggtg agacacttgg acctgtcatc aagtagccat
     5881 ccacctcaaa taaataatct tcaaagaaaa gaaatgcttc ttttatcatt tcaaaatgtt
     5941 ccgtaagaat acgctcatct tggaaatata aatagtgttc ccaaatatga gtacataacc
     6001 atggaatagt taatacccaa attgcagccc ccatggcatg agattgggga gccgtatcgc
     6061 caaaaccatc cgtattatga tgtgctgtaa aacctctagc tccatacatt ttcttagcgg
     6121 ttagtcttcc cggttctctc attctttcga gcatatcaaa taatggatat tctacttctg
     6181 gtaaatcaca tggacctacc atccaataat tcatttgagt attaatatta atcgtatatt
     6241 tagaacccca aattggattt aattcatcac accatattcc ttgaagattg gcaggtaaac
     6301 cattcggttg actagacgat attaacagat atcttccata atgaaataac aagttagtca
     6361 agtagttact atacttttta gtgttttcaa gaagtagatt cgttggaatg ctaagacaac
     6421 ctttactata gtctagttta aaatcaactc tattaaattg ctcctgatat ttttttacat
     6481 gttcatcttt ttctgtaaag taatcaatac tactaaattc tccctgaaga gaagaaatat
     6541 ctatatttcc ccaataatcc gtcattgatt tgagataaag aaatacctct gtagcattcc
     6601 gaataactat tgtctctccc aatacactta cttcaccatc cgtaacctta gaatgacata
     6661 ctactttaaa ctgaacacct tttctacctc cagcagaggc cgacattaaa attgtacttg
     6721 aatccagttt agatacttcg tcattaaacc gtttatttct acccaaatta atgtttaaat
     6781 ttaatgtgtt ttgaactgat gacactatac ggcaacataa aatattctta ttaaaactcg
     6841 taaaatattc tctttttatt tgtaaattac aactattagg ctcaaacaca acattagaaa
     6901 tagctgtatc taaatctagc tctctttcat acaatgaaag agcacaagac tgaatatcta
     6961 tatgctcaat gtaaagttcc ccaagtaatt catagtggct ttgatctctt ggggtagcaa
     7021 acactgttaa ctttatcaat tcttcggctt tctgaatttc tccatctaaa agatattccc
     7081 gaattttttt aagatgcaat agtgagtctg gattatttct atctgacttt cctctatacc
     7141 aaatagtctc atcgtttagt tgaatacatt cttttgtagc tgaaccataa atcataccac
     7201 ctaaatgacc gttcccaatc ggcaaggctt cattccaatt tgcggcagct ttcttatacc
     7261 ataatttcac tctttacctc tcttccaaaa tggaggtgat atcccaaata ccacctccac
     7321 actttctact acttcaaaat tcctaaaaca actagaataa ctccaatagc cataacacta
     7381 aagattagta caaccggatt ctttcctttt ctaattaatt tacacattaa taaagtcaaa
     7441 gccataggga taaatcctgg aattaatttt gtaatcattt cttgaacaga aataacaagt
     7501 tccccctgct taaattctaa tccaaaatta ataccaacca ttgatggaat caaaccaccc
     7561 actagtacta gccctaatgc tgtcgccata ctcgtaacgc gattcaatgt tccttttgta
     7621 ttattttctt ggataagact agaaccctta gtatacccat atttcaaacc gaaatattta
     7681 acaggaatat taataatatt aaacaatatt aaggcgataa agatacctaa agcaccgccg
     7741 tctttagaat aagacgcacc aatactaaaa cagataggaa ctagtgtcag ccagaacaaa
     7801 ctatctccta gaccagccag tggccccatc aagccaactt taataccagt aattgaagct
     7861 gcaccttcat ttccttcttg ttcttccata gcggaagtaa ctccaagaat aaatggtgcc
     7921 gctgtttgat gagtattgaa aaactcaagg tgacgtttca ttgcaggaga agctgaatct
     7981 ttgtctgggt atagtttttt caatactgga agaattgtat atagaaaacc taggttctgc
     8041 attctctcat agttccatga agaaccatac ataaaacttc gtttgaaaac ttttttaagt
     8101 tcaactttag ttactttatt attcatcata gatcaagatc ctcctcaaca tcactacttg
     8161 aagttgtttc ttgtggtttg cttccaatca tatcgtagaa gtatgctacc gcaataccaa
     8221 ctagtgagat cccaatggtt gacattcctc catacacaga acaaatgaat ccaatcaaca
     8281 agaataccca catatttttc ttgagcatca tatttaaaag cataccaaaa ccaattgaag
     8341 gtagtaaagc acctgcagag ttaagtccct gcataacgat tggtggaacc ttagcaaaca
     8401 agtctgccac atattcccct ccaagcataa tagctaggaa aattggtaca attttaaata
     8461 acgtgattaa aaccaaactt gaataatgat aaaaaccgat ctttgaataa tctccgtttt
     8521 tagcatcatt atcagctttt ttcacaaaat aaacatctaa agtttttgca agaacatcca
     8581 actgttgggt agcaactgca attggaactg ctatagcgat accagcagtt tctccttgac
     8641 cagataaaat accaaatgca gtaccaataa tcgcacctga aatagtatct ggtggagtat
     8701 aacctccaat acctgttaca ccgagccaag ttaattcaag agctgaacca ataagaacac
     8761 cttgggtgaa atctcctaat actaagccaa ccattgcact tgtaactaac ggacggtgaa
     8821 tcataaataa cggtccatta tagtcaatag tggcaataat cccaactaat gtcaccagta
     8881 atgcttgtgt gaatagcata tactgtacct ccttaaatta tttttataaa aatttttcca
     8941 acattgtaac tttatcatta ggaaccattt gaatttcaac tctcgttccc ttatcaacta
     9001 ttttcttaaa ataatatttg tcttcttcac ctagagctac acctcccgtt accttttcat
     9061 tttcctccgt tttactcatc tgtcctacat tgaggtactc caattttaaa tttccttcaa
     9121 tagaatcata cacatctttt ggatttgtat atatcagcat tgttctcttt tttattggca
     9181 cagagtttaa aacttccaca aaccgtttta cactaaagaa aacaattttt aaacctaccg
     9241 gtgcagaaat ctttaaaata gattgtcgtg ttttatcttc tgagatgcga tcattaacaa
     9301 tgataacttg ctcaatatca tactttttta gccacgtagt gacaacttga ccatgtacca
     9361 gacggtcatc aatacgaaca aactctatag acataaatct tcttcctcct ctacgttaag
     9421 ttgttgttta acattaaaca aactattttg agcattgtga acaatttctt ctaaattgat
     9481 ttttgaatca taacttgata ttaattccac taggagaggg atattaaacc ctgttacaat
     9541 atcaactgaa tccaaattta aaaaccgtga caaagccaca ttattaggac ttcctccaat
     9601 caagtcagtc aaaacgataa cctcttgatt tgagtctaac agttcatcca cttgattttt
     9661 aaaataatgc tcaaactcta caatattctc tccaggcatc aaacctaatg tcctaactct
     9721 atcatttgtt gtctcaccaa caaacatttc tgcggtcatg agagctccgc tagcaaaatt
     9781 accatgactg gcaactaaaa ttcctctatt gaacattttc tctttcaaca actactcctt
     9841 tcttaaggat aatattagca taaagtgaag tttctcctgt agcaacaata gcataagctt
     9901 tcttactacg ttcataaaag tcttctcttc taagataagt aatcgtttta agatctgtac
     9961 catgaccttc aatcatctgt ctataggtac cccatatctt aggaatatca tcacccgaaa
    10021 caacgttcat aaactgaatt gaactatcga cgtaactatc taatggcatt aaatacagaa
    10081 tggaatctaa taattctgga atatttacac catcacaacg aattagctta tttgcacatg
    10141 aggcagaagg ataattcgcg tcagctaata ctatttcatc tccatgtccc atttccatta
    10201 aagtcttcaa taaatctgga gaaatatttt tcggtatatg ttttaacatt aatatcctcc
    10261 ctattttctc tgaccgtatg ttttaaattt ttctgccatc aattccatct cctcatcagg
    10321 aagaactact ggctctccaa aattcttagc taaacaataa atttttgcac aatattcaac
    10381 ttcttcaaca atattaaatg cattcaataa attttgtgca cctgctaaaa ttccatgatt
    10441 cgctagtaaa actgctctac gaccttccat tgctttagct gcattcacag ccaattcttt
    10501 cgtgccatat gttgcatact cagctacccg aacatctttc cctgccactg caatcatata
    10561 atgactcgct ggaagtggtt ctctgagaca agctaatact gttgcataag ttgtatgagc
    10621 atggataatt gcatcgatat catcacgagt ttgatattga atcaaatgca tataccattc
    10681 gctagatggc aagcgttctc cctctacaac atttccatta atatccatca ctacaatatc
    10741 ggattctttg atttcaaaga aatcaatacc cgacggggta attgccatca attgtttttc
    10801 acgatcgaaa acgctgagat tcccacctgt tcctttcgtc aaatctgttt ctactagctt
    10861 cttaccatat ttaattaatt cttgttttac atctgacatc cttgtcctcc tcatatcaaa
    10921 acactaaata tttttcaatt caccaattat ccccccttcc tgcacaaaag ctaagaaggg
    10981 ggagggaggc aaatttacaa actctcaatc tttttaattc ttttgggagt aataactctc
    11041 taattgtaga aactcctcaa taacatggtg agcctcttcc atccctttta attgtcccat
    11101 agctatgagc tgcacaacaa tattccccac agctgtagcc tcagtcaaac ctgtaagaac
    11161 ctctttacca gttctatcag caatcatttg gttaaagtaa ctggctctag cacctcctcc
    11221 aatcacatat atcctcttat aaaccttatg agttagttct tctagtaact ctatcgcttt
    11281 cctatacgtt tcagctaggc tttcataaac aatcttaaat agttgtccat ctgtccactc
    11341 tctagtttca tgatgataag ctagatattc tgtcaaagtc ttgtgcatat cagattctgt
    11401 tgcaaattca gttgattcag tatcaatcag aggaagattt tctttttctt tctccaccat
    11461 tgtcctaata tcatcaaaag aataggcttt ccctcttcgt tcaaatgaac gtcttagttc
    11521 ctctatgatc cacaaccctg tacaattctt cagaaatgta atcactccat ctttaccgac
    11581 ttcatttgta aatccataac tgaaggattc ggtagtaaga atcggtgaag taagttccac
    11641 tccaaccaaa gaccaagtac ctgatgaaat aaataaacta ccttctgtct taggtactga
    11701 gacaatcgcg cttgctgtat catgactaca aacattcaca acaggaatat cgcctaaacc
    11761 atactcctct tttatccttc caagaacatt tccctctgaa acaatttcag gaagtaaaga
    11821 tgaatccaat tcaaatagtt ttaagatatt ctgattccaa ttttgactcc taggatcaaa
    11881 taattgagtt gttgaagcaa tgcttttttc tgtagcaaac ttacctgtca agagataatt
    11941 aaacaaatct ggcattaaaa gaatcttatt ggtcttatag aaagagtcag gagattcttg
    12001 acgtgcctta aagagttgaa acaaggtatt tatctccata atctgatttc ctgtctctga
    12061 atacagtttt tctaattcag tcatttcaga tatttccttt aacactccct ttgttctttc
    12121 atcacgataa tgaacaggtt gtaataacag cttaccttca ttatcaatca gtccaaaatc
    12181 aactccccat gtgtcaatac cgatagataa aatcttgtaa ctagtattag ccaagcggat
    12241 actttcaaga attttagcta gtagaaagtc aatatcccaa gataaatgcc cttttactct
    12301 aataggtaga ttagaaaagc gatttatttc ttccattact agtttatttt cagaaaggta
    12361 accaacgatt gctcttccag aagtcgcacc taaatctatt gctaaaaccg cttccatttt
    12421 tcttctctct tcgtccttga ttaactttat tataatcccc acgttttatt ttttcaatat
    12481 gtgaacgctt acttgaataa tgttcaaatg ttaacccaat attcataaaa ataattcaaa
    12541 ttcctccaat ttgtgctata atatagttga aatgataaat taggaggagc ttatgataaa
    12601 agatgaacgt gtacttgaat tgattgaaat tatcaaaaag aaaaaaagaa ttgccgtaaa
    12661 agagctggca gaaatcactt tctccagcac aagtacctta cgtcgtgatt taattttctt
    12721 agaaaatcaa ggtcttatca aaagaaagca cggatacgtg accctgtcct ctatgaacac
    12781 aattgaactt tctcatcaaa tacgtgaagg agaaagtact aggcaaaaaa gactaatcgc
    12841 tagtctcgct aaagacttta ttcggtctgg tatgtgtatc tatctagatt ctagtactac
    12901 tgtctacgaa ctctgtccct atctttctga acttgataat ttgattattt ttacaaatgg
    12961 tttacatact gcacaaaccc tatctgaaac tgttaaagat agctccaaaa tctttatcac
    13021 atctggcgag gtcaaacatc aatcctgttc cgtggtcaac tatgataagg aaaattcttt
    13081 attagatcat tttaatatcg atttagcatt ttgttcagca agaggtattg atgaccaata
    13141 tgtttatgaa gcttctctca gccaagctat ttcaaaaaag aatattattg acaaagccca
    13201 tgaaaccatc ttactgattg atagttctaa attttacaag actggatttt ttaaaattaa
    13261 tcccctctcc aaatacacaa cctttatttc agacaccgtg ccagatcaaa aattattaga
    13321 cgcagtcgaa ttatttgatg gagaatgggt ttctgatatt caatga
//
