LOCUS       NC_000964               7241 bp    DNA     linear   CON 18-SEP-2018
DEFINITION  Bacillus subtilis subsp. subtilis str. 168 complete genome.
ACCESSION   NC_000964
VERSION     NC_000964.3
DBLINK      BioProject: PRJNA76
            BioSample: SAMEA3138188
KEYWORDS    RefSeq; complete genome.
SOURCE      Bacillus subtilis subsp. subtilis str. 168
  ORGANISM  Bacillus subtilis subsp. subtilis str. 168
            Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1
  AUTHORS   Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C.,
            Sekowska,A. and Vallenet,D.
  TITLE     Bacillus subtilis, the model Gram-positive bacterium: 20 years of
            annotation refinement
  JOURNAL   Microb Biotechnol 11 (1), 3-17 (2018)
   PUBMED   29280348
REFERENCE   2  (bases 1 to 7241)
  AUTHORS   Belda,E., Sekowska,A., Le Fevre,F., Morgat,A., Mornico,D.,
            Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A.
  TITLE     An updated metabolic view of the Bacillus subtilis 168 genome
  JOURNAL   Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013)
   PUBMED   23429746
REFERENCE   3  (bases 1 to 7241)
  AUTHORS   Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G.,
            Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and
            Danchin,A.
  TITLE     From a consortium sequence to a unified sequence: the Bacillus
            subtilis 168 reference genome a decade later
  JOURNAL   Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009)
   PUBMED   19383706
REFERENCE   4  (bases 1 to 7241)
  AUTHORS   Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G.,
            Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S.,
            Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S.,
            Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M.,
            Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A.,
            Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T.,
            Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D.,
            Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N.,
            Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G.,
            Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A.,
            Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L.,
            Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C.,
            Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M.,
            Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V.,
            Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C.,
            Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M.,
            Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H.,
            Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M.,
            Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M.,
            Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M.,
            Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R.,
            Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P.,
            Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T.,
            Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T.,
            Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M.,
            Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H.,
            Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K.,
            Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E.,
            Yoshikawa,H. and Danchin,A.
  TITLE     The complete genome sequence of the gram-positive bacterium Bacillus
            subtilis
  JOURNAL   Nature 390 (6657), 249-256 (1997)
   PUBMED   9384377
REFERENCE   5  (bases 1 to 7241)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-SEP-2018) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   6  (bases 1 to 7241)
  AUTHORS   Genoscope -,C.E.A.
  CONSRTM   AMAbiotics and Genoscope
  TITLE     Direct Submission
  JOURNAL   Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue
            Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1
            Genoscope / CEA (Commissariat a l'energie atomique et aux energies
            alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail:
            seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr)
REFERENCE   7  (bases 1 to 7241)
  AUTHORS   Genoscope -,C.E.A.
  CONSRTM   Institut Pasteur and Genoscope
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage :
            BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr -
            Web : www.genoscope.cns.fr)
REFERENCE   8  (bases 1 to 7241)
  AUTHORS   Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes
            Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE. E-mail: moszer@pasteur.fr,
            antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33
            (0)1 45 68 89 48
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AL009126.
            On Aug 12, 2009 this sequence version replaced NC_000964.2.
            On or before Mar 17, 2009 this sequence version replaced
            gi:32468687, gi:32468690, gi:32468695, gi:32468704, gi:32468715,
            gi:32468723, gi:32468738, gi:32468743, gi:32468745, gi:32468758,
            gi:32468767, gi:32468778, gi:32468787, gi:32468796, gi:32468802,
            gi:32468809, gi:32468813, gi:32468825, gi:32468830, gi:32468833,
            gi:32468840, gi:38680335.
            Annotation results relative to BLAST similarities, COG
            assignations, enzymatic function prediction (PRIAM software), TMHMM
            and SignalP predictions, and synteny conservation (Syntonizer
            software) are available in the MicroScope annotation platform
            http://www.genoscope.cns.fr/agc/microscope.
            The large cluster comprising the i, h and g rDNA regions could not
            be properly resolved, we therefore incorporated the original
            sequence of rRNAihg in the final assembly.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7241
                     /organism="Bacillus subtilis subsp. subtilis str. 168"
                     /mol_type="genomic DNA"
                     /strain="168"
                     /sub_species="subtilis"
                     /type_material="type strain of Bacillus subtilis"
                     /db_xref="taxon:224308"
     gene            1..312
                     /gene="gmuB"
                     /locus_tag="BSU_05810"
                     /old_locus_tag="BSU05810"
     CDS             1..312
                     /gene="gmuB"
                     /locus_tag="BSU_05810"
                     /old_locus_tag="BSU05810"
                     /function="16.1: Circulate"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /note="Evidence 2a: Function from experimental evidences in
                     other organisms; PubMedId: 18177310; Product type t :
                     transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q9KSH5|4.A.3.2.6"
                     /protein_id="NP_388462.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05810"
                     /db_xref="EnsemblGenomes-Tr:CAB12400"
                     /db_xref="GOA:O05505"
                     /db_xref="InterPro:IPR003501"
                     /db_xref="InterPro:IPR013012"
                     /db_xref="InterPro:IPR036095"
                     /db_xref="SubtiList:BG12190"
                     /db_xref="UniProtKB/Swiss-Prot:O05505"
                     /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKED
                     MRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVNQ"
     gene            312..644
                     /gene="gmuA"
                     /locus_tag="BSU_05820"
                     /old_locus_tag="BSU05820"
     CDS             312..644
                     /gene="gmuA"
                     /locus_tag="BSU_05820"
                     /old_locus_tag="BSU05820"
                     /function="16.1: Circulate"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /note="Evidence 2a: Function from experimental evidences in
                     other organisms; Product type t: transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72XQ1|4.A.3.2.8"
                     /protein_id="NP_388463.2"
                     /db_xref="EnsemblGenomes-Gn:BSU05820"
                     /db_xref="EnsemblGenomes-Tr:CAB12401"
                     /db_xref="GOA:O05506"
                     /db_xref="InterPro:IPR003188"
                     /db_xref="InterPro:IPR036542"
                     /db_xref="SubtiList:BG12191"
                     /db_xref="UniProtKB/Swiss-Prot:O05506"
                     /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEAD
                     ALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEMLDL
                     FKTKNI"
     gene            663..1991
                     /gene="gmuC"
                     /locus_tag="BSU_05830"
                     /old_locus_tag="BSU05830"
     CDS             663..1991
                     /gene="gmuC"
                     /locus_tag="BSU_05830"
                     /old_locus_tag="BSU05830"
                     /function="16.1: Circulate"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /note="Evidence 2a: Function from experimental evidences in
                     other organisms; PubMedId: 15849754, 16850406, 18177310;
                     Product type t: transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72XQ0|4.A.3.2.8"
                     /protein_id="NP_388464.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05830"
                     /db_xref="EnsemblGenomes-Tr:CAB12402"
                     /db_xref="GOA:O05507"
                     /db_xref="InterPro:IPR003352"
                     /db_xref="InterPro:IPR004501"
                     /db_xref="InterPro:IPR004796"
                     /db_xref="SubtiList:BG12192"
                     /db_xref="UniProtKB/Swiss-Prot:O05507"
                     /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVVL
                     TNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGGAI
                     ALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKNLTI
                     KMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLVGLGS
                     GIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHIISKPF
                     MEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGLPIVMNP
                     IIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIMGGVMQLI
                     NLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM"
     gene            2009..3406
                     /gene="gmuD"
                     /locus_tag="BSU_05840"
                     /old_locus_tag="BSU05840"
     CDS             2009..3406
                     /gene="gmuD"
                     /locus_tag="BSU_05840"
                     /old_locus_tag="BSU05840"
                     /EC_number="3.2.1.86"
                     /function="16.11: Scavenge (Catabolism)"
                     /experiment="publication(s) with functional evidences,
                     PMID:14652714, 15139916, 18177310"
                     /note="Evidence 1a: Function from experimental evidences in
                     the studied strain; PubMedId: 14652714, 15139916, 18177310;
                     Product type e: enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q86Z14|8.A.49.1.2"
                     /protein_id="NP_388465.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05840"
                     /db_xref="EnsemblGenomes-Tr:CAB12403"
                     /db_xref="GOA:O05508"
                     /db_xref="InterPro:IPR001360"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR018120"
                     /db_xref="SubtiList:BG12193"
                     /db_xref="UniProtKB/Swiss-Prot:O05508"
                     /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEKE
                     PHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAADF
                     YNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGGRVK
                     KWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQDGKIG
                     IILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGFMPDYN
                     AEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRKMNPHRG
                     WEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRIEFIKEHL
                     KWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVKKSGKWFKE
                     VAEHSGF"
     gene            3549..4262
                     /gene="gmuR"
                     /locus_tag="BSU_05850"
                     /old_locus_tag="BSU05850"
     CDS             3549..4262
                     /gene="gmuR"
                     /locus_tag="BSU_05850"
                     /old_locus_tag="BSU05850"
                     /function="16.3: Control"
                     /experiment="publication(s) with functional evidences,
                     PMID:18177310"
                     /note="Evidence 1a: Function from experimental evidences in
                     the studied strain; PubMedId: 18177310; Product type r:
                     regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|GntR,DBD-SUPERFAMILY|0037767"
                     /protein_id="NP_388466.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05850"
                     /db_xref="EnsemblGenomes-Tr:CAB12404"
                     /db_xref="GOA:O05509"
                     /db_xref="InterPro:IPR000524"
                     /db_xref="InterPro:IPR011663"
                     /db_xref="InterPro:IPR028978"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="SubtiList:BG12194"
                     /db_xref="UniProtKB/Swiss-Prot:O05509"
                     /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMKR
                     ALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQFEV
                     QFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDSIYN
                     HITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEYSFSR
                     HRHDKFVVTSVNIRR"
     gene            4291..5190
                     /gene="gmuE"
                     /locus_tag="BSU_05860"
                     /old_locus_tag="BSU05860"
     CDS             4291..5190
                     /gene="gmuE"
                     /locus_tag="BSU_05860"
                     /old_locus_tag="BSU05860"
                     /EC_number="2.7.1.4"
                     /function="16.11: Scavenge (Catabolism)"
                     /experiment="publication(s) with functional evidences,
                     PMID:15018644, 18177310, 21185308"
                     /note="Evidence 1a: Function from experimental evidences in
                     the studied strain; PubMedId: 15018644, 18177310, 21185308;
                     Product type e: enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK fructokinase; glucomannan utilization protein
                     E"
                     /protein_id="NP_388467.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05860"
                     /db_xref="EnsemblGenomes-Tr:CAB12405"
                     /db_xref="GOA:O05510"
                     /db_xref="InterPro:IPR000600"
                     /db_xref="PDB:1XC3"
                     /db_xref="PDB:3LM9"
                     /db_xref="PDB:3OHR"
                     /db_xref="SubtiList:BG12195"
                     /db_xref="UniProtKB/Swiss-Prot:O05510"
                     /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQYF
                     SQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFSTDV
                     NAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHPDDV
                     YQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYILILAP
                     KKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAGIIGTL
                     VLAHQALQAEAASGEVRS"
     gene            5187..6134
                     /gene="gmuF"
                     /locus_tag="BSU_05870"
                     /old_locus_tag="BSU05870"
     CDS             5187..6134
                     /gene="gmuF"
                     /locus_tag="BSU_05870"
                     /old_locus_tag="BSU05870"
                     /EC_number="5.3.1.8"
                     /function="16.11: Scavenge (Catabolism)"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /note="Evidence 2b: Function from indirect experimental
                     evidences (e.g. phenotypes); PubMedId: 10704478, 18177310,
                     3017192; Product type e: enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphohexomutase; cupin family"
                     /protein_id="NP_388468.1"
                     /db_xref="EnsemblGenomes-Gn:BSU05870"
                     /db_xref="EnsemblGenomes-Tr:CAB12406"
                     /db_xref="GOA:O05511"
                     /db_xref="InterPro:IPR001250"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014628"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="SubtiList:BG12196"
                     /db_xref="UniProtKB/Swiss-Prot:O05511"
                     /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHAH
                     GSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDYAK
                     LHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKPGDF
                     FYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVITIPHI
                     DKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSGRIINN
                     GIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP"
     gene            6153..7241
                     /gene="gmuG"
                     /locus_tag="BSU_05880"
                     /old_locus_tag="BSU05880"
     CDS             6153..7241
                     /gene="gmuG"
                     /locus_tag="BSU_05880"
                     /old_locus_tag="BSU05880"
                     /EC_number="3.2.1.78"
                     /function="16.11: Scavenge (Catabolism)"
                     /experiment="publication(s) with functional evidences,
                     PMID:2694961, 7727534, 18177310, 28101462, 25355936"
                     /note="Evidence 1a: Function from experimental evidences in
                     the studied strain; PubMedId: 2694961, 7727534, 18177310,
                     28101462, 25355936; Product type e: enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="GH26"
                     /protein_id="NP_388469.2"
                     /db_xref="EnsemblGenomes-Gn:BSU05880"
                     /db_xref="EnsemblGenomes-Tr:CAB12407"
                     /db_xref="GOA:O05512"
                     /db_xref="InterPro:IPR000805"
                     /db_xref="InterPro:IPR016714"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR022790"
                     /db_xref="PDB:2WHK"
                     /db_xref="PDB:3CBW"
                     /db_xref="SubtiList:BG12197"
                     /db_xref="UniProtKB/Swiss-Prot:O05512"
                     /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVMN
                     WLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETANI
                     EDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTVEGK
                     RLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYKQLYK
                     KIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSINGYDQL
                     TALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNKGASALY
                     HDSWTLNKGEIWNGDSLTPIVE"
ORIGIN
        1 ttgaaaaaaa tattactcgc gtgcagttca ggaatgtcta ccagtttatt ggtgacaaaa
       61 atgaaggaat acgcacagtc tatcggtgag gaagcggaga tttgggctgt tggccaggat
      121 aaagcaaaag aagacatgag aaaagcggat gccgttttga tcggtccgca aatgagcttt
      181 ctgaaaagcg agctccaaaa agaagcagat caatacaaca ttcaagttga agtcattgac
      241 atgatggcct acggaatggc agatgggaaa aaagcgtatg agcaggcatt gtccttaatg
      301 gtgaatcaat aatggaacag atgaaaatca cgaatttaac agacgagcaa atcagttttc
      361 agctaatcct gcacagcgga aatgcccgca gctgcatcat acaatcactg cgcgcctata
      421 aagaagggaa aaaggacgag gctgatgccc tcattgccaa ggcggagcag gatttatccg
      481 cggcccatga cattcacttt caaatgatac agaaggaatc cggcggagaa gcaacagctt
      541 tttcattgct gcttatgcat gcagaggatc atctgatgtc aacattatcc atgaaagaat
      601 tagtgaaaga gatgcttgat ctctttaaaa ccaagaatat ataaaaaatc ggggtggata
      661 gggtgttcga gaaaatcagc caattccttg ttccaattgc agggaggtta aacaataacc
      721 gctatttgca agtgttgcgt gatgcattta tgctggcttt cccgctgacg atattcgggt
      781 ccatttttgt cgtgttaacg aatttgccgt ttctaaacaa aatcatgaac gcctcaatgc
      841 ttacgtcgtt tcagtctcat ttcggcattg cctccacggc gacaatgggc attatgtctg
      901 tctttgttgt gttcgggata ggctattacc tgtcgaaaag ctatcaggtc gaagctgtat
      961 ttggcggagc gatcgctttg gtttcctttt tgctcttaac gccatttatc attcagccgg
     1021 aaacaggtga tgccattaca ggggttatcc cggtcgatcg tctcggtgca aaagggatgt
     1081 ttcttgggat gattacggca tttctttctg gcgaaattta cagaagaatc gttcaaaaaa
     1141 acctgacaat caaaatgcca gccggcgttc cgcctgctgt agcaaaatca ttcgccgcac
     1201 ttattccggc ttttatcaca ttgactgtat ttttgctgat taacgtaatg gtgactctgt
     1261 tttttaaaac aaatatgcac gacgtcattt atcatgcgat tcaggctccg cttgtcggac
     1321 ttggaagcgg tatcattcca acactgattg ccgtgttttt cattcaaatt ctttggtttt
     1381 tcggactgca tggacagatc attatcaact ccgtgatgga cccgatttgg aatacactgc
     1441 aggtagaaaa cctttctgct tacacggcgg gaaaagaaat ccctcatatt atttcaaaac
     1501 cgtttatgga gatttataca gtagggatgg gcggaacagg gatgacgctt gcgattgtgt
     1561 ttaccattct catattcatg aaaagcaggc agatgaagca agtatcaaaa cttggcctcg
     1621 ctcccggtat ttttaacgta aacgaaccga ttatctttgg gcttccgatt gtcatgaatc
     1681 cgatcattat tgtgccttgg gtgctggcac cgatggttgt tacgctcgtc acctatctgg
     1741 ctatgtcagc cgggctcgtt ccgcctccaa ctggtgtgac agtgccgtgg acggttccat
     1801 tattcattaa tggcatcatg gcgacgaact caatcatggg gggcgtgatg cagcttatca
     1861 atctgctgat tgtcttcgtg atctggtttc cgttcctaaa agcaatggat aaattaaatc
     1921 tggcaaaaga aaaagaacag gctgtgcagg agacagctgc tcagcaaaat gataacagca
     1981 taaaaatgtg acataagggg agagagactt ggcacataca gaacaatatc gttttccaaa
     2041 ggatttttgg tggggatcat ccgcttcagc aacacaaatg gagggtgccg ccgacagaga
     2101 cggaaaaggc cagaatatat gggattattg gtttgaaaaa gaaccgcatc gtttttttga
     2161 tcatgtcgga cccgcagaca catcccaatt ttacgacaac tataaagaag atatcaggct
     2221 gatgaaggaa cttggccaca actcgttccg gatgtcgatt tcctggtcac gtttaatacc
     2281 aaacggaacg ggcgagatca acgataaagc cgcagatttc tataacaatg tcattgatga
     2341 gctgatcgct aacggaattg aaccttttgt caatttgttt catttcgata tgccgatggc
     2401 gcttcaaaaa atcggcggct gggtcaacag agagacggtt gacgcgtatg aaaactatgc
     2461 aagaacttgc ttccgtttgt ttggcggccg ggtgaaaaaa tggttcacgc ataatgaacc
     2521 aatcgttccc gtagaaggcg gatacctata tgattttcat tatccaaaca aggtcgattt
     2581 taaagaggcc gtccaggttg gatttcatac gatgctatca agtgcccgcg ccattcaggc
     2641 ttacagggag atgaagcagg acggaaaaat cggcatcatc ttaaatttga ccccttcata
     2701 cccgagaagc agccatccgg cggatgtgaa agccggggaa atcgcagacg cgttttttaa
     2761 cagatctttt ttagacccat ctgtcaaagg cgaatttccc aaagagctgg ttgacatttt
     2821 gaagcatgaa ggctttatgc ctgattacaa cgctgaagat ctcgacatca tcaaaaagaa
     2881 cacggttgac ctgttgggag tgaattatta ccagccgaga cgtgtgaaag cgaaagaaca
     2941 tcttccgaat cccgacgctc cttttttgcc ggacaggtat tttgatccct acgtcatgcc
     3001 gggccgcaaa atgaatccgc atcgcggctg ggagatctat gaaaaaggcg tttatgatat
     3061 tttgatcaat ttaaaagaaa actacggcaa catcgagtgt tttatctctg aaaacggtat
     3121 gggggttgaa ggtgaagagc gattcaggga tgaacaaggc atcattcagg atgattaccg
     3181 gattgaattt ataaaagagc acctcaaatg gattcaccgc gccatacagg aaggctcgaa
     3241 cgtaaaaggc tatcacttat ggacgttcat ggacaactgg tcttggacaa atgcctataa
     3301 aaaccgatac ggatttgtat cagtcaatct tgagaaagac ggagaaagaa ccgtcaaaaa
     3361 gagcggaaaa tggttcaaag aggttgctga gcatagcggt ttctagattt tcctaaaggt
     3421 caagatcttc cggcaatcat cataacgaat agagatgacg aaaatccgca acattgatga
     3481 aatagggaaa agaacttatg atatccgtaa aagcttatgt gatatcaaac agctgccgga
     3541 ggataccaat gaataaatac gaaatcattg caaatgaaat gagaaataga attaaaaata
     3601 acgtatatcc gatcgatcag cccattcctg atgaagtatc tcttgcaaaa gaatttaact
     3661 caagccgcat gacgatgaag agagccttgg ataatttagt tgccgagggt ctgctgttta
     3721 gaaaacgagg ccatggcacg tttattattc aatctgcaat acaggatgac catgtccatg
     3781 tagtcagcaa tgagattctc ggattgacca acttgctgaa agataaaaaa atcaaaagca
     3841 aggtcattca gtttgaagtg caatttccca ctgaggaagt ggccgcccat ttgtctattg
     3901 atcagaaaac accggtttat tatgtcgttc ggctgcgaat tgtagaaggt gaaccctatg
     3961 tattagaaaa aacatatatg ccgactcatt taataccggg cattaatgac gatgtccttc
     4021 atgattcgat ctacaatcat attacaaatg tgctgcagct caaaatcgcc ggaacgcatc
     4081 ggaaaatcag agcctgcaaa tctgatcata ttgaccagca gcatctgggc tgtaaacagg
     4141 atgatccaat tcttgaagtg gaacatgtgg gcttcttaga taccgggatt ccatttgaat
     4201 attccttttc acgtcatcgg catgacaagt ttgttgtgac ttctgtaaac atacggcgct
     4261 gattgcggag acaacaagga ggccatctgc atgcttggcg gtattgaagc aggcggcaca
     4321 aagtttgttt gtgctgtcgg tagagaagat ggaacgatca ttgacaggat agaattcccc
     4381 acaaagatgc cggatgaaac gatagagaaa gtaattcaat attttagcca attttcatta
     4441 caggcaatcg gcatcggctc ctttggtccc gttgataacg ataaaaccag tcaaacatac
     4501 ggtaccatta cggccacgcc gaaagcgggc tggagacact atcccttttt gcaaaccgtt
     4561 aagaacgaaa tgaagatccc agtcggattt agtacagatg tcaacgctgc ggcgctgggt
     4621 gaattccttt tcggtgaagc gaagggtctt gacagctgcc tgtatataac gattggcact
     4681 ggcatcggag cgggggctat tgtagagggg aggctccttc aggggctgtc acacccagag
     4741 atgggccata tttatatccg gaggcacccg gatgacgtat accaagggaa gtgcccttat
     4801 catggagatt gctttgaagg cttagcttca ggccccgcta tcgaagcccg ctgggggaaa
     4861 aaagccgcgg atttatcaga tatagcacaa gtctgggaac tggaagggta ctatattgcc
     4921 caagcactgg ctcagtatat tttgatcctt gcacctaaaa aaatcattct tggcggcggc
     4981 gtcatgcaac agaaacaagt gttttcttat atctatcaat atgtaccaaa aatcatgaac
     5041 agctacttag atttttctga attatcagat gatataagtg attatattgt acctccacgt
     5101 ttaggcagta acgccggaat catcggcacg ctagttttag cgcatcaggc cttacaagca
     5161 gaggcagcat ccggggaggt gcgatcatga cgcatccatt atttttagag cctgtcttta
     5221 aagaaagact atggggaggg acgaagcttc gtgacgcttt tggctacgca ataccctcac
     5281 aaaaaacagg tgagtgctgg gccgtttctg cacatgccca tggctcgtcg tctgtaaaaa
     5341 atggcccgct ggcaggaaag acacttgatc aagtatggaa agatcatcca gagatattcg
     5401 ggtttccgga tggtaaggtg tttccgctgc tggtaaagct gctggacgcc aatatggatc
     5461 tctccgtgca agtccatcct gatgatgatt atgcaaaact gcacgaaaat ggcgaccttg
     5521 gtaaaacgga gtgctggtat atcattgatt gcaaagatga cgccgaacta attttgggac
     5581 atcatgcaag cacaaaggaa gagttcaaac aacgaataga aagcggtgat tggaacgggc
     5641 tgctgaggcg aatcaaaatc aagccaggag atttctttta tgtgccaagc ggtacactcc
     5701 atgctttatg taagggaacc cttgtccttg aaatccagca aaactctgat acaacatatc
     5761 gcgtatacga ttatgaccgc tgtaatgacc agggccaaaa aagaactctt catatagaaa
     5821 aagccatgga agtcataacg ataccgcata tcgataaagt gcatacaccg gaagtaaaag
     5881 aagttggtaa cgctgagatc attgtttatg tgcaatcaga ttatttctca gtgtacaaat
     5941 ggaagattag cggccgagct gcttttcctt catatcaaac ctatttgctg gggagtgttc
     6001 tgagcggatc aggacgaatc ataaataatg gtattcagta tgaatgcaat gcaggctcac
     6061 actttattct gcctgcgcat tttggagaat ttacaataga aggaacatgt gaattcatga
     6121 tatctcatcc ttaatgaatg ggggagttgc atttgtttaa gaaacatacg atctctttgc
     6181 tcattatatt tttacttgcg tctgctgttt tagcaaaacc aattgaagcg catactgtgt
     6241 cgcctgtgaa tcctaatgcc cagcagacaa caaaaacagt gatgaactgg cttgcgcacc
     6301 tgccgaaccg aacggaaaac agagtccttt ccggagcgtt cggaggttac agccatgaca
     6361 cattttctat ggctgaggct gatagaatcc gaagcgccac cgggcaatcg cctgctattt
     6421 atggctgcga ttatgccaga ggatggcttg aaacagcaaa tattgaagat tcaatagatg
     6481 taagctgcaa cggcgattta atgtcgtatt ggaaaaatgg cggaattccg caaatcagtt
     6541 tgcacctggc gaaccctgct tttcagtcag ggcattttaa aacaccgatt acaaatgatc
     6601 agtataaaaa aatactagat tcttcaacag tagaaggaaa gcggctaaat gccatgctca
     6661 gcaaaattgc tgacggactt caagagttgg agaaccaagg tgtgcctgtt ctgttcaggc
     6721 cgctgcatga aatgaacggc gaatggtttt ggtggggact cacatcatat aaccaaaagg
     6781 ataatgaaag aatctctcta tataaacagc tctacaagaa aatctatcat tatatgaccg
     6841 acacaagagg acttgatcat ttgatttggg tttactctcc cgacgccaac cgagatttta
     6901 aaactgattt ttacccgggc gcgtcttacg tggatattgt cggattagat gcgtattttc
     6961 aagatgccta ctcgatcaat ggatacgatc agctaacagc gcttaataaa ccatttgctt
     7021 ttacagaagt cggcccgcaa acagcaaacg gcagcttcga ttacagcctg ttcatcaatg
     7081 caataaaaca aaaatatcct aaaaccattt actttctggc atggaatgat gaatggagcg
     7141 cagcagtaaa caagggtgct tcagctttat atcatgacag ctggacactc aacaagggag
     7201 aaatatggaa tggtgattct ttaacgccaa tcgttgagtg a
//
