LOCUS       JX087428               18410 bp    DNA     linear   BCT 17-OCT-2012
DEFINITION  Caldanaerobius polysaccharolyticus xylan gene cluster, complete
            sequence.
ACCESSION   JX087428
VERSION     JX087428.1
KEYWORDS    .
SOURCE      Caldanaerobius polysaccharolyticus
  ORGANISM  Caldanaerobius polysaccharolyticus
            Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
            Thermoanaerobacteraceae; Caldanaerobius.
REFERENCE   1  (bases 1 to 18410)
  AUTHORS   Han,Y., Agarwal,V., Dodd,D., Kim,J., Bae,B., Mackie,R.I., Nair,S.K.
            and Cann,I.K.
  TITLE     Biochemical and Structural Insights into Xylan Utilization by the
            Thermophilic Bacterium Caldanaerobius polysaccharolyticus
  JOURNAL   J. Biol. Chem. 287 (42), 34946-34960 (2012)
   PUBMED   22918832
REFERENCE   2  (bases 1 to 18410)
  AUTHORS   Han,Y., Dodd,D., Agarwal,V., Kim,J., Mackie,R.I., Nair,S.K. and
            Cann,I.K.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-MAY-2012) Microbiology, University of Illinois, 1206 W
            Gregory Ave, Urbana, IL 61820, USA
FEATURES             Location/Qualifiers
     source          1..18410
                     /organism="Caldanaerobius polysaccharolyticus"
                     /mol_type="genomic DNA"
                     /strain="KMCJ"
                     /db_xref="taxon:44256"
     misc_feature    1..18201
                     /note="xylan gene cluster"
     CDS             1..162
                     /codon_start=1
                     /transl_table=11
                     /product="Hypothetical protein"
                     /protein_id="AFM44648.1"
                     /translation="MNRVESSTHYTYSLHFALLCVSPFDLYILYHKIAKRASVMKYLGK
                     KKRKEEET"
     gene            326..2398
                     /gene="agu67A"
     CDS             326..2398
                     /gene="agu67A"
                     /EC_number="3.2.1.139"
                     /note="glycoside hydrolase family 67 alpha-glucuronidase"
                     /codon_start=1
                     /transl_table=11
                     /product="GH67"
                     /protein_id="AFM44650.1"
                     /translation="MDKEVDYSLCWLEYSKIDDEPYREKLSKVVKNIIAVGQDKFTQTA
                     VEELKTAVTSLVGFEPEVSKEALCGDNPISGIIVGNVTDALIMKYISDDEIQKLDEEGY
                     VIKSVKENPGLVVIGSKNGHGLVYGAFSFIKHIQLKRDVEEVHIIDNPKCKLRLLNHWD
                     NMDGTVERGYAGRSIFFCDNKVTNSLGRIKDYARLLSSIGINGVVINNVNVNKNAIWLI
                     TPKYLGDLAKLADVFRQYGIKIYLSINFASPIYIGKLKTADPLDEDVIKWWKETAKTIY
                     EYIPDFGGFLVKADSEFNPGPYKFGRDHADGANMLAEALAPYGGIVIWRCFVYNCTQDW
                     RDTKTDRAKAAYDIFKPLDGKFAENVVLQVKYGPMDFQVREPVSPLFGGLERTNQLIEL
                     QITQEYTGQQIDLCYLATMWKEVLEFDTYAKGPESKVKYVVDGTLFNNKYSGFAGVSNV
                     GSDKNWTGHWLAQANLYAFGMLAWDHSFTPEEIAREWCVRALTNDPFAVETIVSMLMRS
                     WRVYEKYTAPLGIGWMVTPHTHYGPSVDGYEYSKWGTYHRADTKAIGIDRSVKSGTGFA
                     GQYHRENAAMFESMETCPEELLLFFHRVPYDYVLKSGETLIQHIYNTHFEGAEEAEKLK
                     EDWVKIKDYIRKDIYEDVLERFNRQIENAKEWRDVVNSYFYRKTGIPDKYGRKIY"
     gene            2434..4803
                     /gene="xyl3A"
     CDS             2434..4803
                     /gene="xyl3A"
                     /EC_number="3.2.1.37"
                     /note="glycoside hydrolase family 3 beta-xylosidase"
                     /codon_start=1
                     /transl_table=11
                     /product="GH3"
                     /protein_id="AFM44649.1"
                     /translation="MKGNSKESALYLDATQPVEKRVEDLLSRMTLDEKIAQLSSVWVYE
                     LLDNMEFSVDKAKDLLKDGIGQITRIGGASNLGPKESAQLANEIQRYLIENTRLGIPAL
                     VHEESCSGYMAKGATCFPQTIGVASTWNTELVKQMGSVIREQMKAVGAHQALAPLMDVA
                     RDARWGRVEETFGEDPYLISEMGVSYIEGLQGGNIKDGIMATVKHFVGYGFSEGGMNWA
                     PAHIPERELREVFLLPFEAAVKKAKTASVMAAYHELDGIPCHGSKKLLTQILRNEWGFD
                     GLVVSDYFGVNMLYEYHHVARDKGEAAKIALQAGVDIELPSRDCYGQPLKEAVQKGLVE
                     EALIDEVVRRILRMKFLSGVFENPYVDVEKAAEVFDTPDQRKLAYKLAQQSIVLLKNQG
                     DLLPLKKDIKSIAVIGPNADSVRNIIGDYAYPCHIESLVETKEQSNVFNTPVPDKVSLV
                     DNFVPIKSILEGIKGKISPETELHYAKGCEVTGDDKGGFAEAIEAAKKSDVAIVVVGDK
                     AGLTDDCTSGESRDRADLNLPGVQQELVEAIYNTGTPTVVVLVNGRPLSINWISRHIPA
                     IIEAWLPGEEGAAAVADVLFGDYNPGGKLPVSFPRSVGQVPVYYNHKPSGGRSHWKGDY
                     VEMSTKPLYPFGYGLSYTKFEFSNLEIAPSEVYDDGKVRISVDVQNAGKLEGDEVVQLY
                     VRNEVSNVTRPVKELKGFKRVSLRPGEKKKVVFELSVSQLGFYDEDMRYVVQPGTVKVM
                     IGSSSEDIKVAGEFKVTGKTVQVGESKEFFTKVEVV"
     gene            4837..5979
                     /gene="xylI"
     CDS             4837..5979
                     /gene="xylI"
                     /EC_number="5.3.1.5"
                     /note="xylose-isomerase"
                     /codon_start=1
                     /transl_table=11
                     /product="XylI"
                     /protein_id="AFM44651.1"
                     /translation="MFDVRDQKVRRSPDEVLEHLKNFHLDLKFSVGIWYFSPSGSRFKE
                     AASAPRSIEERLDIIASLKDYGVSALEAHYPNEINENNLDTYKKFSKDTGIRILTVIPN
                     LFYQKQWEFSSLASPIDEVRNKAIERLKISLQLNKELNTDFAIVWHGGDGYENPFGIDF
                     MAMRDRFAYGIAEAMDQVPGVRVAIEPKPYEPRGRIIYGTTAEGILVAQKVEGALKNEE
                     NKRILSEGHSLVGLNPEVGHVLMAYEDLPYAFSLAMEYGKLLHTHWNSQPAGNYDQDQN
                     VGVISPEQAEAALYVLKMHGYKGYFGIDINPERMPVEVAVKNNIDAIRSMNARIEELDH
                     EAIVEAVNNPDKHRGLIEAILIRARAPKTISLPPISSVIK"
     gene            5995..7506
                     /gene="xylK"
     CDS             5995..7506
                     /gene="xylK"
                     /EC_number="2.7.1.17"
                     /note="xylulokinase"
                     /codon_start=1
                     /transl_table=11
                     /product="XylK"
                     /protein_id="AFM44652.1"
                     /translation="MSYLIGIDIGTSGTKTVLFDERGNTVASSTVEYDMAQPEIGWAEQ
                     DPEDWWKATCQSLREVIGKSGINVDEIKGIGLSGQMHGAVLLDKDGNVLRSAIIWCDQR
                     SSAECEEITDIIGYGRLIELAANPALTGFTAPKVMWVKKHQPEIFEKIAHILLPKDYIR
                     YRLTGEFATEVSDASGTLFLNVKERKWSREIVEKLGLNIEWLPEVYESHVVSGKVCKKA
                     AESTGLKEGTPVVGGGGDQAAGAVGNGIVKKGLVSSTIGTSGVVFAYTDKVTIDPKGRV
                     HTFCHAIPDTWHVMGVTQGAGLSLKWWRDNFGFEEKTLGSLTGTDPYVYMDKEAEQAQP
                     GCGGLIYLPYLMGERTPHLDPYAKGVFFGLTAKHRRQEVIRSVLEGVVFSLRDCLEIIK
                     GMGIPVEEIRASGGGGRSRIWRQIQADVFKTDIVTINSAEGPALGVALLAGVGTGLYSS
                     VVEACDAVIKRVSVQHPNQSLFDVYEKNYRLYTALYPAVKDLYRL"
     CDS             7540..8190
                     /EC_number="2.2.1.2"
                     /codon_start=1
                     /transl_table=11
                     /product="transaldolase"
                     /protein_id="AFM44653.1"
                     /translation="MKFFIDTANVEEIKEANDLGVISGVTTNPSLVAKEGRDFIEVIKE
                     IASIIDGPISAEVISEDHQGMIQEARKLAAIHNNIVIKIPMTAEGLKAVKALSKEGIKT
                     NVTLIFSANQALLAARAGATYVSPFVGRLDDISTEGMQLIRDIVEIFKNYDISTEIIVA
                     SVRHPMHVLKAAKLGAHIATVPYKVIMQMIKHPLTDAGIQRFKEDWKKANLKI"
     gene            8208..9977
                     /gene="transketolase"
                     /note="nonfunctional due to possible sequencing errors"
     CDS             10727..11935
                     /EC_number="2.7.13.3"
                     /note="periplasmic sensor signal transduction histidine
                     kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|F4LXP4|8.A.59.2.1"
                     /protein_id="AFM44655.1"
                     /translation="MIQSTNWYNRLLNLNGGYILEVNAGGLLENNKDNQGYISFIRVIN
                     DINTQKPSGIMIINISKLYLSKYINSAINTYTSSIILKDEKGNSIIEPTNISKNLNNKI
                     FNYIRPNGSTIKNINGEVYIISHIENEFGWNIISITPFNELNSQFWIYNIILLFVIIIN
                     VILLILGLLFISLFITQPIIKLVNSMKGIKDGKFEKVNIITGNDEIGMLKDVYNKMIDE
                     IKKLISDIINEQKIKRKLELEVMQSQIKPHFLFNSFDAISALILMGDTKNASKIVKALG
                     KFYRSFLINGEEITIKEELDIINSYLTIQKIRFGDKFNVEKDIDERTLSYKIPKLILQP
                     LVENALNHGIRSKDGQGIISIKALHGDNQIKLIVEDNGKGMSEEKIKEIECGKSKVLAL
                     DPQ"
     CDS             12045..13529
                     /note="Helix-turn-helix, AraC type:Response regulator
                     receiver"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_AraC,DBD-SUPERFAMILY|0036286"
                     /protein_id="AFM44654.1"
                     /translation="MIKDKIKVLIIDDEYLERNLLKGCIDWDMLGMEIVGEASNAEEGF
                     KLIDEFKPNVVFTDIKMPGIDGIKFSESILQKYPTIKIVVVTGYNDFVYAQKSVKIGVS
                     DFLLKPIDEDEVLNTVYKLKAVIENERKKKEEFEELKRQLYDNLPYLKERFLNELINGN
                     LDDNLVKEKLEFFDIPLNGSIYQVAVLEIINSNDVNEESRLIQNFKVINYVKSYFKELR
                     RIMVFADSMNRIIILNNDEKLDLYKTCIRLKNKIIRDVDCIVNIGIGNIKGRISDIKVS
                     YEEAIDALNYRIAVGNNSVIHYRDVQFTESKTGLDTNHLFNELRFYLKSGLENNAINVV
                     KDIFSNLDLKSENAIKLIRVTALNVISICFTVSLELKENFDDIYLSEVESYNKIINIET
                     LPDMIEYISTIVRNTIKAINKEQINNINNLIANVKKFIEENIGDSNLSLSYVAKHFYLN
                     PSYLSRTFKKETGINFIEYLTNKRMEKAINLIKEKT"
     gene            13913..15232
                     /gene="xbp1"
     CDS             13913..15232
                     /gene="xbp1"
                     /note="xylo-oligosaccharide binding component of ABC
                     transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="Xbp1"
                     /protein_id="AFM44656.1"
                     /translation="MKGFKKLMLIVLSLLLVLSASACSSNNLSKSNTSNSSKTSSSSKK
                     ITLTFWNLFTGEPAKTKVKEIIDQWNKENPNVQIVESVTENDAYKTKIKAAIAANEAPD
                     IFQTWAGGFSQPFVEAGKVLQLDSYLNDGTKDQLLPGSFDNVTYNGKIYGIPFDQQASV
                     LYINKELFDKYNVKVPTTFSELIDAIKTFKSKGVTPFALGEKDEWPGMWYYDMIALREG
                     GVQLTRDALNGKASFDNQAFTDAAQKLQDMVNAGAFDSGFMGLTRDEATAEFNQGKAAM
                     YFGGNFDAAAFVSDPSSLVKGKIEAVRFPTIEGGKGDPTEYIGGTVGALMVSANSKYKD
                     EAVRAAKYLAKQLSDMDYLIATGLPAWKYDNIDQSKVDPLEIQIMNNIVANAKGSVPAW
                     DIYLSGDAAQTHKDLVAQLFAKQITPEEYSKQMQQKINGK"
     CDS             15353..16237
                     /note="permease component of ABC transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|O51924|3.A.1.1.7"
                     /protein_id="AFM44657.1"
                     /translation="MEKILSDKKAIFLFVFPAFLVFLVIVLLPIFFSFYYSLLKWDGFS
                     KGVFIGLENYKNLFINNTDGFIISVKNSFILAVLSVFIQLPIALLLALILSRGIKGEKF
                     YRTVYFIPVILSTVVIGQLWMKIYNPNYGLLNFILTKIGLQSLTNQWLGNTKTALGAVF
                     VPILWQYIGYHMLLMYASAKSIPTDIYEAAKIDGATESQIAFRITIPLMKPILKVCVIF
                     AVIGSFKAFDLIYVLTNGGPLHASEVPSTLMYNMIFFRYQYGYGSAMAIFIILESLIGT
                     LIIQKLFGKDVAY"
                     /old_product="permease"
     CDS             16252..17112
                     /note="ATP-binding component of ABC transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="AFM44658.1"
                     /translation="MENIAGENKKSWFKKIGFYVLEAILVIWAIVQIYPLFWLFLFSVK
                     NNTEIFGGNILGFPRIWQWSNYAVALSSGNVGKYFINSTIVTVLTIIISSILVATSAYA
                     IVRMKWKYSKLVLTIFLTGMMVPLHATLLPLFIILKNLNLLNTYASLVIPYVAFAIPMG
                     IFILTGFLYTIPRELEESAFLDGCSIYKSFYYVILPLIRPALATIAIFTYLSTWNELMF
                     ANTFINDDAIKTLTVGIMSLSGQYQTEWGPIGAGLVIATIPTILIYVLLSEQVQKSLVV
                     GAIKG"
     CDS             17401..18201
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase"
                     /protein_id="AFM44659.1"
                     /translation="MKISFGYYHGGKKKALTMSYDDGQVFDRRLVEIFNKYGIKGTFNL
                     NSGRFDTEPYVSKKEIKELYKGHEVAVHSLNHPCLSLIPPEELAYQIMEDRKNLESLVG
                     YQVRGMAYPYGDYSDALLNSLTSFGIEYSRTVKSTKSFGIPNNFLEWHPTCHHDQDVIQ
                     KLKEFKNLKEWEQMPLFYVWGHSFEFDRNGNWDLIEEFCKMASFDETVWYATNIEIKDY
                     IDALRSLKFSADRSMVYNPSAIPVWIGVDGEPIKIDSGERIKLK"
ORIGIN
        1 atgaataggg tcgaaagttc cacccattat acctattctc ttcactttgc tctcctctgc
       61 gttagtcctt ttgatttgta tatattatat cataaaatcg caaaaagggc atctgtaatg
      121 aagtatttag gtaaaaagaa gagaaaagaa gaggaaacgt gagcaatact ttaagaacaa
      181 gaaaaaacag cgaatataag gtgaatttag tcaaatttaa tgaaatttaa gctttgaaaa
      241 tattttcata gtgaggtaag atagaactgg caacttaata aacttttttt aaaaagttag
      301 agggggaaaa ggagaggtat gggtaatgga taaagaagtg gattactctt tatgctggct
      361 tgaatacagc aaaatcgatg acgaacccta tcgagaaaag ctatcaaagg tagtaaaaaa
      421 tatcatagcg gtaggacaag ataaattcac gcaaaccgcg gttgaagagc ttaaaactgc
      481 tgttacatcc cttgtgggtt ttgaaccgga ggtttccaaa gaggccttat gcggtgataa
      541 tccgataagt ggcattatcg taggaaatgt aactgatgcg ttgatcatga agtatattag
      601 cgacgacgag attcaaaaat tagatgaaga agggtatgtt ataaagtctg taaaggaaaa
      661 tccaggatta gtggtgatag gctcaaaaaa tgggcacgga cttgtgtatg gcgcatttag
      721 cttcataaag cacatacagt taaaaagaga cgtggaggaa gtacatataa tagacaatcc
      781 caagtgcaaa ttgaggttat taaaccattg ggacaatatg gatggaacgg tagaaagggg
      841 ctatgcagga agatcaatat ttttttgtga caataaggtt acgaactctt taggccgcat
      901 aaaggattac gccagactgc tgtcttctat tgggataaac ggtgtggtca taaacaatgt
      961 aaacgtcaat aaaaatgcca tctggcttat aacccctaaa tatttggggg atctggctaa
     1021 attggctgat gtgttcaggc aatacgggat aaaaatatat ctcagcataa attttgcgag
     1081 tcctatctac atcggtaagc tgaaaaccgc tgatcctcta gatgaagatg tgatcaaatg
     1141 gtggaaagaa acagcaaaga ccatctacga atatattccg gattttgggg gctttttagt
     1201 taaggccgat tctgaattta atcctggacc ttataaattt gggcgcgacc acgctgacgg
     1261 ggcgaatatg ctggcagagg ctttggcgcc atacggcggc atcgttatat ggaggtgctt
     1321 tgtatacaat tgtactcaag actggagaga tacgaagaca gatagggcaa aggcagctta
     1381 cgacattttt aagccactag acggcaagtt tgcggaaaat gtggtgcttc aggttaaata
     1441 cggacctatg gattttcagg tgagagagcc tgtatctcct ttatttggag ggctggagag
     1501 gaccaatcag ctgattgaat tgcagataac ccaggagtac accggacagc aaattgacct
     1561 gtgctatctt gccacgatgt ggaaagaagt cctcgagttt gacacgtacg ccaaaggacc
     1621 tgaatctaag gtaaagtacg tcgtagatgg aacgcttttt aataataaat acagcggttt
     1681 cgcaggggtt tcaaacgtgg gaagcgataa aaactggacg ggtcactggc tggctcaggc
     1741 taatctgtac gcctttggta tgctggcttg ggatcacagc tttacccctg aggaaattgc
     1801 tcgcgagtgg tgcgtaaggg ctcttactaa tgatcctttt gctgttgaga ccatcgttag
     1861 catgctgatg agatcgtggc gtgtttatga aaaatatacc gctcctcttg gaatcggttg
     1921 gatggttacc cctcataccc attatggtcc ttcagtggac ggatatgagt actcaaagtg
     1981 gggcacttat catagagctg acaccaaagc tattggaata gacaggagcg taaaatcagg
     2041 tacaggcttt gcaggacagt atcacaggga aaatgctgct atgtttgaat caatggagac
     2101 atgccctgag gagctgttgc tgttcttcca tcgcgtgcct tatgattacg tgctaaaatc
     2161 cggagaaacg ttgattcagc acatttataa cacccatttt gagggggcag aagaagcgga
     2221 aaaattaaag gaggactggg taaaaataaa ggattatatt cgcaaggaca tctatgaaga
     2281 tgtattagaa agatttaata gacaaattga gaatgcaaaa gagtggaggg atgtcgtaaa
     2341 tagctatttt tacaggaaga caggcatccc agataaatat ggccgaaaaa tatattaaat
     2401 attattaatt tataaaggag gattggttta acaatgaagg gcaacagtaa agaaagcgca
     2461 ctgtatttag acgctaccca gcctgtggaa aaaagggtgg aggatctttt gtccaggatg
     2521 accttggatg aaaaaatcgc tcaattgagc agcgtgtggg tttatgaatt gttagataac
     2581 atggagtttt ctgttgacaa ggcgaaggat cttctaaaag acggaattgg gcagataacc
     2641 cgtataggag gggctagcaa cctgggtcct aaagaatcag cacagttggc caatgaaatc
     2701 cagaggtatc tgatagaaaa taccaggtta ggtatccctg ctcttgtcca tgaagaatcg
     2761 tgcagcgggt atatggcaaa gggagccacg tgttttcccc agactatcgg cgttgccagt
     2821 acatggaaca cggagctcgt aaagcaaatg ggttctgtga taagagagca gatgaaggca
     2881 gtaggagccc atcaagccct ggcgcccctt atggatgtgg ctagggatgc caggtggggt
     2941 agagtggaag agacctttgg agaagatcct tatttgattt cggaaatggg tgtctcttat
     3001 atagaaggcc ttcaaggagg aaatataaag gatggcatta tggccactgt taagcatttt
     3061 gtagggtatg gattttcaga aggtggaatg aactgggcgc ctgcccacat cccggagagg
     3121 gagcttagag aagtgttcct tttgcctttt gaagccgcgg taaagaaggc aaaaacagca
     3181 tcggttatgg cggcttatca cgaactggac ggtataccat gccacggttc gaagaagctg
     3241 cttacgcaaa tcctcagaaa tgaatggggc tttgatggac tggtggtgtc ggattacttt
     3301 ggtgttaata tgctttacga ataccatcac gtggccaggg ataaaggcga agcagctaag
     3361 attgctctgc aagcgggcgt tgatatcgag ttgcccagta gggactgtta cggccaacct
     3421 ttgaaagagg ctgtacaaaa aggtcttgta gaggaagccc tgattgacga agtagtgaga
     3481 aggatactga gaatgaaatt cttgtcaggg gtttttgaga acccgtacgt ggacgtcgag
     3541 aaggcagctg aagtatttga tacgccggat cagagaaagt tggcttataa gctggcgcaa
     3601 cagtccatcg tattgcttaa aaaccaaggc gatctattgc ctctgaaaaa ggatataaaa
     3661 tctatagcag taatcggccc caacgctgac agcgtcagaa acatcatcgg agattacgct
     3721 tatccctgcc atatagagtc gctggtagag acgaaagaac agtctaatgt gtttaatacc
     3781 cctgtgcctg acaaagtcag ccttgtggat aattttgtcc ccataaagag catattggaa
     3841 ggcataaaag gcaaaatttc tcctgaaacc gagctgcact acgccaaagg atgtgaggtc
     3901 actggagacg acaaaggtgg ttttgctgag gctattgagg cggctaagaa atccgatgtg
     3961 gccatagtgg tagtaggtga taaggccggt ttaaccgatg actgcacttc gggagaatcc
     4021 agggatcgcg ctgatctcaa tctgcctggg gtacagcaag agctggtgga ggcgatttac
     4081 aacacaggta ctcctacagt agtagtgctt gttaacggca ggccgctttc tataaactgg
     4141 atatctcgac acattcccgc tattatagag gcgtggttgc ctggtgaaga aggggcagcg
     4201 gcggtggcag atgtgttgtt tggggattac aaccctggtg gaaaacttcc cgtttcgttc
     4261 ccaaggtctg tagggcaagt tcctgtatat tataatcata agccctctgg cgggcgctcc
     4321 cactggaaag gcgattatgt ggagatgagc acaaaacctt tgtatccatt tggttacgga
     4381 ttgagctaca cgaaatttga gttttccaat ctggaaattg cccctagcga agtatatgat
     4441 gacggcaagg tgaggataag cgtggacgtt caaaatgcag gcaagctcga gggagatgaa
     4501 gtggtacagc tttatgtgcg caatgaggtt tctaatgtaa cgagacctgt taaagagtta
     4561 aaagggttta agagggtttc tctgcggcct ggggaaaaga aaaaggtggt ttttgaacta
     4621 tcagtatccc agctgggatt ttacgatgaa gatatgagat acgttgtaca acctggaact
     4681 gtaaaggtga tgatcggcag ttcttctgag gacataaagg tggccgggga atttaaggtc
     4741 acaggtaaaa cagtccaggt aggagagtca aaagaatttt tcacaaaagt ggaagttgtt
     4801 taatttaaat tattctataa ggaagagggt gttattgtgt ttgatgtaag agatcaaaaa
     4861 gtgaggagat caccggatga ggtgctggag caccttaaga atttccacct agaccttaaa
     4921 ttttcagtag gtatttggta tttttcgcca tcaggcagca ggtttaaaga ggctgcgtcg
     4981 gcgcccaggt ctattgagga gaggttggat ataatagcgt cccttaaaga ctacggtgta
     5041 agcgcgctgg aagcccatta ccccaatgag ataaatgaga ataacctgga cacgtacaag
     5101 aagttttcta aagacacagg tataaggata ttgactgtaa tacccaatct attttatcag
     5161 aagcaatggg aattttcttc actggcttca cctattgatg aggtgcgaaa taaagccatt
     5221 gaaaggctga aaatatcttt gcagctcaac aaggagttaa acaccgattt tgctatagta
     5281 tggcatggcg gtgacggcta tgagaacccc tttggtatag attttatggc catgagggat
     5341 agatttgcgt acggcatagc cgaagccatg gatcaggtgc ctggggtgag ggttgcgatt
     5401 gagcccaaac cttacgagcc tcgtgggagg attatatacg gcaccacggc tgaagggatt
     5461 cttgtggctc agaaggtgga gggagcgctt aaaaacgagg aaaataagag gattttaagt
     5521 gaaggccatt cgctggtggg gctaaaccct gaagtaggcc acgtgctgat ggcgtacgag
     5581 gatttgcctt acgcttttag ccttgccatg gaatacggta aactgctgca tacccactgg
     5641 aacagccaac ctgctggtaa ttatgatcag gaccagaacg taggagtgat ttcccctgaa
     5701 caggcagaag ctgccctgta cgtcttgaag atgcacggat ataagggata ttttggaatc
     5761 gatataaatc ccgagaggat gcctgtggaa gtggctgtga agaataatat tgatgcgatt
     5821 aggagtatga acgcgaggat tgaagagctt gaccatgagg cgatagttga agctgtgaac
     5881 aatcctgata aacaccgagg attaatagaa gctattttga taagagccag agcgcctaag
     5941 accataagct tacctccgat aagctctgtg ataaaatgat gggaggatta aattatgagt
     6001 tatctgatag gtattgatat aggcacatcg ggaacaaaga cggtgctgtt tgatgagaga
     6061 ggaaacactg ttgccagcag cacggtggag tacgacatgg cacagcctga gatcggatgg
     6121 gcggagcagg accctgagga ttggtggaaa gccacatgcc agagcttgag agaggtcata
     6181 ggcaaaagcg gtattaatgt agatgaaata aaaggcatcg ggctgtcagg gcaaatgcac
     6241 ggtgcggtgc ttttggacaa agacggcaat gtgttgcgga gtgccataat ttggtgtgac
     6301 cagaggagca gcgccgaatg tgaagagata acggatatta tagggtatgg ccgcttgatt
     6361 gaattagcgg ccaatcccgc tttgacgggt tttacagccc caaaagtcat gtgggttaaa
     6421 aaacaccaac ctgagatttt tgagaaaatc gctcatatac tgcttcccaa ggactacata
     6481 aggtataggc ttacagggga atttgccaca gaggtgtctg atgccagcgg cacgctgttt
     6541 ttaaacgtaa aggagagaaa atggagcagg gagatcgttg aaaagctagg tttgaacata
     6601 gagtggttgc ctgaggtgta tgaatcccat gtggtgagcg gaaaggtatg caaaaaagcc
     6661 gccgaaagca cagggttaaa agaaggaacg ccggtggtgg gaggtggtgg agatcaggcg
     6721 gcaggagcgg taggcaacgg catcgtaaaa aagggcctgg tgtcctctac tataggtaca
     6781 tcaggggtgg tgtttgccta caccgacaaa gtcacaattg accccaaagg ccgcgtccat
     6841 accttttgcc acgccatacc tgacacgtgg cacgtgatgg gagttactca gggagcggga
     6901 ctttcgttga agtggtggag ggataacttt ggctttgagg aaaagaccct ggggtcgctc
     6961 accggtaccg atccgtatgt atacatggat aaagaagccg agcaggcaca gcccggttgc
     7021 ggagggttga tttacctgcc gtatctcatg ggggaacgta ctccgcacct ggatccctat
     7081 gcgaaagggg ttttctttgg actcacggcc aaacacagga ggcaggaagt tataaggtct
     7141 gtgttggaag gcgtcgtgtt tagccttagg gattgccttg agataataaa aggcatggga
     7201 atacctgtgg aagaaataag ggcatcagga ggaggaggca ggagcaggat ctggagacag
     7261 attcaggccg atgtctttaa aaccgacata gttactatca attcagcaga aggccctgcg
     7321 ttgggcgtag cgctactggc cggagtgggt acaggccttt attccagcgt agtggaagcc
     7381 tgtgatgccg ttataaagag agtaagcgtt cagcatccca atcagtccct atttgatgtg
     7441 tacgagaaaa attacaggct ttatacagct ctataccctg cggttaagga tttgtacagg
     7501 ttgtagcggt gaggatttcg taattgagga gggatgggtg tgaagttttt tattgacacg
     7561 gccaatgtgg aggagataaa agaggccaac gatttagggg taatatccgg cgttaccacc
     7621 aacccatcgc tggtggccaa agagggcagg gatttcatcg aggtgataaa agagatcgca
     7681 tccattatag acggccctat aagcgcagag gtcataagcg aagaccacca gggcatgatc
     7741 caggaggcgc ggaaactggc tgctatccat aacaacatag ttatcaagat ccccatgaca
     7801 gcagaagggc tcaaagccgt taaggcgctt tcaaaagagg ggataaagac caatgtgacc
     7861 ctcatattta gcgccaacca ggcgctgctg gcagccaggg caggggctac gtacgtaagc
     7921 ccctttgtgg gaagattgga cgacataagc acagagggca tgcagctcat acgggatata
     7981 gtcgagatat ttaagaatta cgacataagc accgagataa tcgtggccag cgtaaggcat
     8041 cccatgcacg tgcttaaagc cgccaaactg ggtgcccaca tagccaccgt gccgtataaa
     8101 gttataatgc agatgataaa acaccctctg acagacgcgg ggatacagag gtttaaagag
     8161 gactggaaga aggccaattt gaagatataa agcaggaggt aagatacatg gataaccaga
     8221 gactagcaca catcgcaaca gaagtcagga agagcataat aaaggctgtg acagcggcaa
     8281 aatccggaca tcccggaggg tcgctgtcag ctaccgacat actggtcaca ctgtactttg
     8341 acgtgatgag gatagatccc aacaacccca aatgggagga cagagacaga tttgtgctgt
     8401 ccaaaggcca tgcagcgccg gcgttgtacg ccgtattagc cgagaggggt tactttgcca
     8461 aagaagaact gatgaggctg aggcaggtag gatccatact gcagggtcat ccggacatga
     8521 agagcacccc tggtgtggac atgaccacag gttccctggg gcagggattg tctgcggcca
     8581 acgggcatgg cgctggcggc gaagctggac aaaaaagact acagggtgta cgtgatgctg
     8641 ggagacggag agatacaggg aaaggcatgg tgtgggaagc ggccatgaag cgcagcccac
     8701 ctacaggctg gacaacctaa cggcattttt tagactacaa tcagctgcag atagacggtg
     8761 ccaacgacca agtcatggcc ataaacctgt ggcagacaag tggagggcct ttggatggaa
     8821 tgtactggag atagacggac acgactacga tcaaataaaa agcgcggtag agaaggcgaa
     8881 agcgaccaaa ggcaaaccta ccatggtgat agcccatacc gtaaagggca agggagtatc
     8941 ctacatggag aaccaggtag gatggcatgg gagcgcaccc aacgaagagc agatgaaaaa
     9001 agcactaaca gaattggggg attgagatga gcaagaagat agcgacaaga gaatcctacg
     9061 gaaaagcgct ggtagagcta ggagagatca acaaagacgt agtggtactg gatgcagacc
     9121 tatcaaaatc caccaagacg gcagagtttg cgaaaaaata tcccgatagg tttttcaaca
     9181 tgggcatatc agagcaggac ctcataggta cggcggcggg cctggccaca tgtgggaaga
     9241 taccctatgc cagctccttt gcgatatttg ccacagggag ggcctttgag cagataagga
     9301 actccatagc ctatcccagg ttaaacgtta agatagcagc gacccatgca ggcataacgg
     9361 tgggagagga tggggcgacc caccagtcgg tagaggacat agcgataatg aggtcgatac
     9421 ccggaatggt ggttataaac ccagcggacg atgtagaggc gagggccgcg gtaaaagcgg
     9481 cgtgcgagta caaaggaccg gtgtacatca ggctgggcag gatgggagtg cctgtgatat
     9541 acgatgacaa aagctacagg tttgagatag gcaaagggat agagctaaga gaaggaagcg
     9601 acgtgaccat agtagcgacg gggataatgg tggcagcggc gctggaagcc catgaagagt
     9661 taaagaagaa agggataagc gcgagggtga tagacataca caccataaag cccatagacc
     9721 aggagctgat agtgaaggcg gcgtgggaga caggagcgat agtgacagca gaggagcaca
     9781 gcgtgatagg gggattaggt tcagcggtat gcgaggtagt cagcgaaaag gtaccggttc
     9841 ccgtaaggcg ggtagggata agagatgtat ttgggcagtc agggaagccc gatgagctat
     9901 tgaagctgta tcatcttacg cctgaagata tagtggaaga agctttaaag gcgttggaga
     9961 ttaaaaagcg caggtgataa aaaagccgca gaaggatcaa aaattcttct gcggcttaga
    10021 tgcatataca tcaattaagg aattacttta aatatgtttc atataaacat ccgcaataaa
    10081 ggttgggaaa gcaattggga tgttttaagc cattttacaa atttcctaat gaagtaagga
    10141 aaataatgta tacgacaaac ataattgaga ttctacaggc agttaaggga agttataaaa
    10201 taaaaaacaa tacttccatc agatgaaact ttagagataa ttgtagagtc gcaataatgt
    10261 tgttatttaa taccttactc caaaggagtt aatattatgt tgaaaaggtt tactagaaaa
    10321 cttggtgatc ttaatatttc aactaaaata attttgtact acatgtttgt tttaataatt
    10381 tcgatttctt ttctttcaat agcatacaaa gagataaaca atagcattac aaacaataaa
    10441 gttatgcagg tttcaaatag aaatcgtttc gaacattaat tccaatattg aatcgttaat
    10501 caattcagtt gataaccaat caaaaatact gatttcgagc caaattttac aagctgccct
    10561 ttcaagcggc aatgctggta ataacgctaa ttacatacag ccgatgaaaa agtatttagc
    10621 ggattttttg gatttcaacg attttatttc gtctatatat atttttgata acaatggaaa
    10681 taaatatttc gtcgataacg tttcttttaa aagtataagt ttacccatga tacaatctac
    10741 taactggtat aacaggctat taaatttaaa tggcggatac attttagaag taaatgctgg
    10801 tggtctgctg gaaaataaca aagacaatca aggttatatc tctttcatca gggtaataaa
    10861 tgatataaat acgcaaaagc cttcaggcat aatgataata aacatatcaa aattatattt
    10921 aagtaaatat ataaacagcg ccatcaatac ttatacatca agcattatac taaaagacga
    10981 aaaaggcaac agtataatag agccaactaa tataagcaaa aatttaaata acaagatatt
    11041 taattatata aggcctaatg gctccactat aaaaaatatt aacggagaag tgtacatcat
    11101 ttcgcacata gaaaatgaat ttggatggaa tataataagc ataacaccat ttaatgagct
    11161 caacagtcaa ttttggatat acaatataat acttctattt gtcataataa taaatgtcat
    11221 attgcttatt ctagggctat tgtttatatc gctgtttatt acacagccca taataaagct
    11281 ggtaaactct atgaagggaa taaaggatgg aaaatttgaa aaagtaaata ttataaccgg
    11341 caatgatgag atagggatgc taaaagatgt ttataataag atgatcgatg aaattaaaaa
    11401 attaattagc gacatcatta acgagcaaaa aattaaaaga aaattggaac tagaagtaat
    11461 gcaatcacag ataaagccgc attttctatt taattctttt gacgcaataa gtgctcttat
    11521 attgatggga gatactaaaa atgccagcaa gattgtcaaa gcactgggta aattttatag
    11581 atctttctta attaatggcg aggaaatcac cataaaagaa gagctcgaca taataaacag
    11641 ttaccttaca atacaaaaaa taaggtttgg agataagttt aacgtagaaa aagatattga
    11701 tgagcggaca ttaagctata aaataccgaa gcttatatta cagccattgg ttgaaaatgc
    11761 cttaaaccac ggtataagaa gcaaagacgg tcaaggaatc atttcaataa aagctttaca
    11821 tggtgataat caaataaagc ttatagtaga agacaatgga aaaggcatga gtgaagaaaa
    11881 gataaaagaa atcgagtgcg gtaagtctaa ggtgttggcc ttagatccac aatagaaagg
    11941 ttgaaaaata tattacaatt ctgcggatgt agtgaaaatt tacagtaaaa taaatgagag
    12001 aacaaagatc gaaataacta tccctataaa caaggaggag cagaatgata aaggataaga
    12061 taaaagtgct cattattgac gatgagtatc ttgaaagaaa tctattaaaa ggttgtatag
    12121 attgggacat gcttggaatg gaaatagtag gcgaagcgtc aaacgcggag gaaggtttta
    12181 aactaataga cgaatttaag ccaaatgtag tctttaccga cataaaaatg cccggaattg
    12241 acggtataaa attcagcgaa tctattttac aaaaatatcc tacaataaag attgtcgttg
    12301 tcacaggcta caatgatttt gtctacgctc aaaaatccgt aaaaataggg gtatctgact
    12361 ttttgcttaa gccgatagac gaagatgaag tcttaaatac cgtatataag ctaaaagcag
    12421 tcatagaaaa tgaaagaaaa aagaaagaag aatttgaaga attaaaaaga cagctttacg
    12481 ataatctacc ttatttaaaa gaacgatttt taaatgagtt gataaatggc aatttagacg
    12541 ataatttggt aaaagaaaag ctagaattct tcgatatacc tttgaatggc agtatttatc
    12601 aagttgccgt tttagagatt atcaattcaa atgatgtaaa cgaagaatct cgtctgattc
    12661 aaaattttaa agtgatcaac tacgtaaaaa gttattttaa agagttgaga aggataatgg
    12721 tttttgctga ttcaatgaat agaattatca tcttaaataa cgacgaaaaa ttagatctgt
    12781 ataaaacctg tataagacta aaaaataaaa tcatcaggga tgttgactgt attgtaaata
    12841 ttggcatagg aaatataaaa ggaaggataa gtgacatcaa agtatcgtac gaagaggcaa
    12901 tagatgcatt aaattaccgc atagcagttg gcaacaacag tgtcatacat tacagagacg
    12961 tgcaatttac agaaagcaaa actgggctcg acactaatca cctgtttaat gaattgagat
    13021 tttacctgaa atcaggttta gaaaacaatg caataaatgt ggtaaaagac atattttcta
    13081 atttagacct taaaagcgaa aatgcaatca agttgatccg tgttacagca ttaaatgtaa
    13141 tatcaatctg tttcactgtg tcattggaac taaaagaaaa ctttgatgat atatatttat
    13201 ctgaagtaga gtcatacaac aaaatcataa atatagagac gctgcctgac atgattgaat
    13261 atatatcaac aattgtaaga aatacaatta aggcaataaa caaagagcag ataaacaata
    13321 tcaacaattt aatcgctaat gttaaaaaat tcatagagga aaatatcggc gatagtaatc
    13381 tttcgctgtc gtacgtcgca aaacactttt acttaaatcc cagctattta agcaggacat
    13441 ttaaaaagga gacaggcata aactttatag aataccttac aaataagcga atggaaaaag
    13501 caataaattt gataaaagaa aaaacatgaa attatttgaa atcgctaatg cagtcggcat
    13561 acaagaccct aattattttc atcgtgcttt aaaaagtata caggtttaaa agtaagtgag
    13621 tacaaaaaat tgataaaaag tattgtaaaa tcttagggac tcgaaaggtt gttgtcaaaa
    13681 aaatatagag taatcagggt atttcctgat aatccaaacg ttggtgatag aaacacctgg
    13741 ttctagccag agggattttt acactaaaat ttggacttga ccttatatgg taaataaaca
    13801 aggtaaaaaa attgaagatt gtagtaaaaa aattatattc ataatgatga tttagtattt
    13861 tatcatgtat atgtaaacta ttttaaaatt atttgagaaa ggatgtgtgg taatgaaggg
    13921 atttaaaaaa ttgatgctga ttgtgttatc tttattgcta gtacttagtg catcggcgtg
    13981 tagttctaat aatttaagca agtcgaatac ttcaaactca tcgaagactt caagttcgtc
    14041 aaaaaagata acgcttactt tttggaattt atttactggc gaaccggcaa aaacgaaagt
    14101 taaagagatc atcgatcagt ggaataaaga aaatccaaat gtgcagattg tagaaagcgt
    14161 gacagaaaat gatgcgtaca agacgaagat taaagctgca attgctgcaa atgaagcacc
    14221 tgatattttc cagacttggg ctggagggtt ttcacaacct tttgtagaag cgggaaaggt
    14281 tcttcagtta gatagctact taaacgatgg cacaaaggat caattgctac caggttcttt
    14341 tgacaatgtc acatataatg ggaaaatata tggtattcca tttgatcaac aagcaagtgt
    14401 actctatata aataaagagc tttttgataa atacaatgta aaggttccaa ccacatttag
    14461 tgaacttatc gacgctataa agacatttaa gtctaaaggt gtaacgcctt ttgccttagg
    14521 tgagaaagat gaatggcctg gaatgtggta ctacgacatg attgcacttc gcgaaggtgg
    14581 tgtacagctt acaagagatg ctttaaacgg caaggcatca tttgacaatc aagcttttac
    14641 agatgcagct caaaagttac aagacatggt taatgcgggt gcgtttgatt ctggttttat
    14701 gggtcttaca agggatgaag ccacagcaga atttaaccaa gggaaagctg ctatgtactt
    14761 tggaggaaat ttcgatgcag cagcatttgt ttcagatcca tcatctcttg taaaaggtaa
    14821 aattgaagca gtgagattcc ctacaattga aggtggcaaa ggagatccta cagagtatat
    14881 tggcggtaca gttggagcat tgatggttag tgcaaattca aagtacaaag atgaggcagt
    14941 tagagctgcc aagtatcttg caaaacagtt atcagatatg gactatttga tagctactgg
    15001 cttaccagcg tggaaatatg acaatataga tcaatcaaaa gttgatccat tagagataca
    15061 gattatgaat aatatcgttg caaatgctaa gggtagtgtt cctgcttggg atatttatct
    15121 tagtggcgat gctgctcaga cacataaaga tttagttgct caattgtttg caaaacagat
    15181 tactccagaa gagtattcaa aacaaatgca acagaagata aacggaaaat aatgatattt
    15241 tcaatttcct gctaattact tgataattag caggaaatta tttaacgata tagtaattta
    15301 tattattgaa aatgtattgt gtgcttttat tacttttgtt aggaggtttc ctatggagaa
    15361 aatcttaagc gataaaaagg ctatattcct atttgtgttt ccagcatttt tagtcttttt
    15421 agtcatcgta ctgcttccaa tatttttttc tttctactac agtttgctaa aatgggacgg
    15481 attcagcaaa ggagtattta ttggtcttga gaattataag aacctattta taaacaatac
    15541 agatggattt attatctcag tgaaaaactc gtttatctta gctgtattgt ctgtttttat
    15601 ccaactgcct attgctcttt tactggctct tattctttca aggggaatta aaggtgagaa
    15661 gttttacagg actgtttact tcataccggt tattttgtct accgtcgtca taggacaact
    15721 ttggatgaaa atatacaatc ccaattacgg gcttttaaat tttatactga ctaagatagg
    15781 acttcaatca cttacaaatc agtggttggg aaatactaag acggctctcg gggcggtctt
    15841 tgtacctata ctgtggcagt atattggcta tcatatgctc ttaatgtatg catcagcaaa
    15901 atcaatacct acagatatat atgaagctgc aaaaatcgac ggtgccactg aatcacagat
    15961 tgcattcagg ataacaatac ctcttatgaa acctatattg aaggtttgcg tcatattcgc
    16021 tgttatcggt tcatttaaag catttgacct catctatgtt ttgacaaatg gcggtccatt
    16081 acatgccagt gaggtgccgt caacattgat gtacaacatg atattcttta gatatcaata
    16141 tggatatgga agcgcaatgg ctatatttat cattttagaa tcattaatag gaacgttgat
    16201 tatacaaaaa ttatttggaa aagatgtagc atattaaagg tggtgtgtga attggaaaat
    16261 atagctggtg aaaataaaaa gagttggttt aaaaaaatag gattttatgt acttgaagct
    16321 attttagtta tttgggcgat agtgcaaatt tatcctttat tttggctatt cttattctct
    16381 gtaaaaaaca atactgaaat atttggagga aatatacttg gatttccgcg tatttggcaa
    16441 tggtcaaact atgctgttgc tttgtccagc ggcaatgtag gcaagtactt tataaacagc
    16501 acaatagtca ctgttttaac tattataata tcgagcattt tggtggcaac aagcgcatat
    16561 gcgattgtaa ggatgaagtg gaagtacagt aaattagttc ttacgatatt tttaactggc
    16621 atgatggtgc ctctacatgc tacactgctt ccgttattta taatattgaa gaatctgaac
    16681 ttgcttaata cgtatgcatc gctggtaata ccatacgttg cattcgctat acctatgggg
    16741 atatttatat tgacaggctt cctttacact ataccgaggg agttagagga atcggcattt
    16801 cttgatggat gtagcatata caagtcgttt tattacgtta tattgcctct tataaggccg
    16861 gcattagcga ctatagcaat atttacgtac ctttctacgt ggaatgagct tatgtttgct
    16921 aatactttta taaatgacga tgccataaag acattgacag ttggtattat gtctttgtca
    16981 ggacaatatc aaactgagtg gggaccaatt ggtgctggac ttgtgattgc tacgattcct
    17041 actattttga tatatgttct tcttagcgaa caagtgcaaa agagtcttgt agtaggagca
    17101 ataaagggat aaaaggataa aatagtaaaa gaaaaattat cactttacag gggcatatct
    17161 ttacaaagat ccgaattttc agtgctgatg atgccgtaga tatttaaaag atataaaatc
    17221 atctgtatag gtaccgaaga gcatggcttt aatagcgatg atggaaggtg taccttagta
    17281 gtgggattat ttacgttgta tataggtgga agtcagccgt atgagataag ccaagagctt
    17341 accggtgatt tgagagaatt ggagtattga aattataaaa ctttagaggg gggaatagag
    17401 gtgaagataa gctttggcta ttatcatggt ggaaagaaaa aagctttgac gatgagctat
    17461 gacgatggcc aggtatttga cagaagattg gtagagatat ttaacaaata cggcatcaaa
    17521 ggcacattca atttgaattc aggcagattt gatacagaac cttatgtgtc taagaaagag
    17581 ataaaagagt tgtataaagg acatgaagta gcagttcatt cattaaatca tccgtgtttg
    17641 tcgttgatac cgccagagga actggcctat caaataatgg aagataggaa aaatctcgaa
    17701 tcgcttgtag gctatcaagt acgaggtatg gcatatcctt atggagacta cagcgatgcg
    17761 ttgctaaata gtcttacatc atttggcata gagtattcta ggacggttaa gtctactaaa
    17821 agctttggga tacccaataa ttttttagaa tggcatccga cttgccatca tgatcaagat
    17881 gttatacaga agctgaagga atttaagaac ctaaaagaat gggaacagat gcctctattt
    17941 tatgtatggg gacacagctt cgagttcgac agaaatggca attgggatct aatagaagaa
    18001 ttttgcaaaa tggcatcatt tgatgaaacc gtgtggtacg ctacaaatat tgaaataaag
    18061 gattatatag acgcattgag gagtttaaaa tttagtgctg atcgcagcat ggtatataat
    18121 ccatcagcaa tacctgtatg gatcggtgta gatggtgagc cgataaaaat agattctggt
    18181 gagagaatta aattaaaatg aaataaggtt atataaaaat catccactat tatgttatgt
    18241 gaagtataac atttgtggat gattttttat tagaaataaa tagcaagaca ggatacatag
    18301 acattgaaga tgacaatgcg cgaaacagca cagtatcaag atatttatac cttcgttttc
    18361 tacaggaact gcctctcata ggacaaaaaa ggctggtggc agagacgtga
//
