LOCUS       NC_004350               9838 bp    DNA     linear   CON 10-MAR-2020
DEFINITION  Streptococcus mutans UA159, complete sequence.
ACCESSION   NC_004350
VERSION     NC_004350.2
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02604090
            Assembly: GCF_000007465.2
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans UA159
  ORGANISM  Streptococcus mutans UA159
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9838)
  AUTHORS   Ajdic,D., McShan,W.M., McLaughlin,R.E., Savic,G., Chang,J.,
            Carson,M.B., Primeaux,C., Tian,R., Kenton,S., Jia,H., Lin,S.,
            Qian,Y., Li,S., Zhu,H., Najar,F., Lai,H., White,J., Roe,B.A. and
            Ferretti,J.J.
  TITLE     Genome sequence of Streptococcus mutans UA159, a cariogenic dental
            pathogen
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (22), 14434-14439 (2002)
   PUBMED   12397186
REFERENCE   2  (bases 1 to 9838)
  AUTHORS   Ajdic,D., McShan,W.M., McLaughlin,R.E., Savic,G., Chang,J.,
            Carson,M.B., Primeaux,C., Tian,R., Kenton,S., Jia,H., Lin,S.,
            Qian,Y., Li,S., Zhu,H., Najar,F., Lai,H., White,J., Roe,B.A. and
            Ferretti,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-SEP-2011) Department of Microbiology and Immunology,
            University of Oklahoma Health Sciences Center, 940 SL Young Blvd.,
            Oklahoma City, OK 73104, USA
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 9838)
  AUTHORS   Ajdic,D., McShan,W.M., McLaughlin,R.E., Savic,G., Chang,J.,
            Carson,M.B., Primeaux,C., Tian,R., Kenton,S., Jia,H., Lin,S.,
            Qian,Y., Li,S., Zhu,H., Najar,F., Lai,H., White,J., Roe,B.A. and
            Ferretti,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2002) Department of Microbiology and Immunology,
            University of Oklahoma Health Sciences Center, 940 SL Young Blvd.,
            Oklahoma City, OK 73104, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/10/2020 06:12:25
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 1,994
            CDSs (total)                      :: 1,910
            Genes (coding)                    :: 1,858
            CDSs (with protein)               :: 1,858
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 33 of 52
            Pseudo Genes (incomplete)         :: 15 of 52
            Pseudo Genes (internal stop)      :: 19 of 52
            Pseudo Genes (multiple problems)  :: 14 of 52
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AE014133.
            On Sep 26, 2011 this sequence version replaced NC_004350.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9838
                     /organism="Streptococcus mutans UA159"
                     /mol_type="genomic DNA"
                     /strain="UA159"
                     /db_xref="taxon:210007"
     gene            complement(1..2277)
                     /locus_tag="SMU_RS07095"
                     /old_locus_tag="SMU.1564"
                     /old_locus_tag="SMU_1564"
                     /db_xref="GeneID:1028802"
     CDS             complement(1..2277)
                     /locus_tag="SMU_RS07095"
                     /old_locus_tag="SMU.1564"
                     /old_locus_tag="SMU_1564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GT35"
                     /protein_id="WP_002262973.1"
                     /db_xref="GeneID:1028802"
                     /translation="MTQKTKQFSKYVQEKTGQNLEQLSNEAIYVQLLHFVKEAAKDMPK
                     NTSKRKVYYISAEFLIGKLLSNNLINLGLYKTVKDELAAAGKSISQVEDVELEPSLGNG
                     GLGRLASCFIDSMATLGINGEGVGLNYHCGLFKQVFRDNQQEAEPNYWIEDDSWLVPTA
                     ISYDVPFRDFTLKSKLDRIDILGYHKDSKNYLNLFDIDGLDYGLIKDGITFDKTEIKKN
                     LTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEALERGSNLHDLADYAYVQINDTH
                     PSMVIPELIRLLNEKHGLDFYEAVDIVKNMIGYTNHTILAEALEKWPLEYLNEVVPHLV
                     TIIEHLDRIVRSQYKDDAVQIIDRDDRVHMAHMDIHFSTSVNGVAALHTDILKNSELKP
                     FYDIYPEKFNNKTNGITFRRWLEFANQDLAAYIKELIGEGYLEDATELEKLLAFADDKT
                     VHEQLAKIKFNNKLALKRYLKENKGINLDENSIIDTQIKRFHEYKRQQMNALYVIYKYL
                     EIKKGNLPKRKITVIFGGKAAPAYTIAQDIIHLILCLSELINNDPDVSPYLNVFLVENY
                     NVTVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGSDN
                     IYIFGKDSDTIIDLYDKGTYVSKDYYTNNAVIKEAVDFIVSKDVLALGKKERLERLYHE
                     LINKDWFMTLIDLKEYIAKKEEMLADYEDQNVWNKKVIQNIAKAGFFSSDRTIQQYDKD
                     IWHSL"
     gene            complement(2249..3778)
                     /gene="malQ"
                     /locus_tag="SMU_RS07100"
                     /old_locus_tag="SMU.1565"
                     /old_locus_tag="SMU_1565"
                     /db_xref="GeneID:1028801"
     CDS             complement(2249..3778)
                     /gene="malQ"
                     /locus_tag="SMU_RS07100"
                     /old_locus_tag="SMU.1565"
                     /old_locus_tag="SMU_1565"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019312918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH77"
                     /protein_id="WP_002262974.1"
                     /db_xref="GeneID:1028801"
                     /translation="MEKRASGILMHISSLPGKFGIGTFGQEAYDFVDFLKKTGQTYWQL
                     LPLTTTSYGDSPYQSFSAVAGNVNFIDFKKLQEAGLLDEDDYNSVSFGEDEEIVDYALL
                     FKVRRPILEKAVINFLADKTNLKKLALFEEKNETWLDDYAEFMAIKEHFGNKSLQEWGD
                     KKAIRRDEERLVRYRHLLADEISYHKVTQYFFFEQWLALKAYANKNKIKIIGDMPIYVA
                     KDSVEVWTMPELFKMDDDLQPLSVAGCPPDEFSDEGQLWGNPIYDWKKHRETGFAWWIY
                     RIQESFKIYDILRIDHFKGFSDYWEIKGNSKTAKNGSWHPGPGIALFRAVQNVLGDMPI
                     IAEDLGYVDDRARQLLKETGFPGMKILEFGFYDLSGRSVDIPHHYVQNSVAYIGTHDND
                     VVNGWYDRLTVEQEEFVDAYTNRKPIEPVNQAMLRLLFSTVSNTAILTMQDLLNKPASS
                     RMNTPSTIGGNWQWRMRAKDLTQDKINFLSKLTKLYQRGNEENDTKNKTIQ"
     gene            complement(3893..4912)
                     /locus_tag="SMU_RS07105"
                     /old_locus_tag="SMU.1566"
                     /old_locus_tag="SMU_1566"
                     /db_xref="GeneID:1028807"
     CDS             complement(3893..4912)
                     /locus_tag="SMU_RS07105"
                     /old_locus_tag="SMU.1566"
                     /old_locus_tag="SMU_1566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|LacI,DBD-SUPERFAMILY|0036955"
                     /protein_id="WP_002262975.1"
                     /db_xref="GeneID:1028807"
                     /translation="MVTIKDVAKEAGVNPSTVSRVLKNSSSISQKTKDRVQQAMTDLGY
                     VPNLAAQMLASGLTHCVGVVFPPLTSPDRLSEPFFMEILAAINNEASRNKFTVSIATSN
                     TLTDLKDQVQLMYRQGRVDGFIVLYSERRDPVRQYLIKNKIPFVIVGAPVDYKDETTYV
                     DNDNQLMAETAVTYLNQKGHKQILFVTNDQESDVYIERFIGYQKGMQALGLQSYDSALF
                     DSKQASTLEAFIKTVQKKKITALLIIGDVVSLRIIQFLSYYGIAVPEDMSIVSFNNSSY
                     ATILHPYLTTFDINVNRLGRASLNCLLEKVQKRQSKDQKVIVPFTLKKRESVRNLKKS"
     gene            5159..6406
                     /locus_tag="SMU_RS07110"
                     /old_locus_tag="SMU.1568"
                     /old_locus_tag="SMU_1568"
                     /db_xref="GeneID:1028671"
     CDS             5159..6406
                     /locus_tag="SMU_RS07110"
                     /old_locus_tag="SMU.1568"
                     /old_locus_tag="SMU_1568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003060926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DT28|3.A.1.1.27"
                     /protein_id="WP_002262976.1"
                     /db_xref="GeneID:1028671"
                     /translation="MKTWQKIVVGGAGLMLASSILVACGSKDSKSSSSDPKTIKLWVPT
                     GAKKSYQSIVHKFEKDSNYKVKIIESEDPKAQEKIKKDPSTAADVFSLPHDQLGQLVDS
                     GVIQEIPQKYSKEINKNETQQAATGAMYKGKTYAFPFGIESQVLYYNKSKLSADDVTSY
                     ETITSKATFGAKFKQVNAYATAPLFYSVGDTLFGKNGEDAKGTNWGNDAGVSVLKWIAS
                     QKGNAGFVNLDDNNVMSKFGDGSVASFESGPWDYEAAQKAVGKNNLGVTVYPTININGQ
                     EVQQKAFLGVKLYAVNQAPSKGNTKRIAASYKLASYLTSAESQENQFKTKGRNIIPSNK
                     TVQNSDTVKNHELAQAVIQMGSSSDYTVVMPKLNQMSTFWTESAAILSDTYNGKIKESD
                     YLAKLKQFDKDLAAAK"
     gene            6483..7844
                     /locus_tag="SMU_RS07115"
                     /old_locus_tag="SMU.1569"
                     /old_locus_tag="SMU_1569"
                     /db_xref="GeneID:1028615"
     CDS             6483..7844
                     /locus_tag="SMU_RS07115"
                     /old_locus_tag="SMU.1569"
                     /old_locus_tag="SMU_1569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003057790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DT27|3.A.1.1.27"
                     /protein_id="WP_002262977.1"
                     /db_xref="GeneID:1028615"
                     /translation="MIQSSSHDQLSVLETFKKGGIDIKLSFVIMGFANLMNKQFIKGLL
                     FLLSEIAFLIAFVTQVIPAFSGLLTLGTKTQGMQEKIVDGVKLQVAVEGDNSMLMLIFG
                     LASLIFCLVFAYIYWCNLKSARNLYMLKKEGRHIPSFKEDFMTLANGRFHMTLMFIPLI
                     GVLLFTILPLVYMICLAFTNYDHNHLPPKSLFDWVGLANFGNVLNGRMAGTFFPVLSWT
                     LIWAVFATVTNFLFGVILALIINAKGLKLKKMWRTIFVITIAVPQFISLLLMRNFLNDQ
                     GPLNAFLEKIGLISHSLPFLSDPTWAKFSIIFVNMWVGIPFTMLVATGIIMNLPSEQIE
                     AAEIDGASKFQIFKSITFPQILLIMMPSLIQQFIGNINNFNVIYLLTGGGPTNSQFYQA
                     GSTDLLVTWLYKLTMNAADYNLASVIGIFIFAISAIFSLLAYTHTASYKEGAVK"
     gene            7844..8680
                     /locus_tag="SMU_RS07120"
                     /old_locus_tag="SMU.1570"
                     /old_locus_tag="SMU_1570"
                     /db_xref="GeneID:1028808"
     CDS             7844..8680
                     /locus_tag="SMU_RS07120"
                     /old_locus_tag="SMU.1570"
                     /old_locus_tag="SMU_1570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DT26|3.A.1.1.27"
                     /protein_id="WP_002262978.1"
                     /db_xref="GeneID:1028808"
                     /translation="MKRKKQLQIGSIYALLILLSFIWLFPIIWVILTSFRGEGTAYVPY
                     IIPKTWTLDNYIKLFTNSSFPFGRWFLNTLIVSTATCVLSTSITVAMAYSLSRIKFKHR
                     NGFLKLALVLNMFPGFMSMIAVYYILKALNLTQTLTSLVLVYSSGAALTFYIAKGFFDT
                     IPYSLDESAMIDGATRKDIFLKITLPLSKPIIVYTALLAFIAPWIDFIFAQVILGDATS
                     KYTVAIGLFSMLQADTINNWFMAFAAGSVLIAIPITILFIFMQKYYVEGITGGSVK"
     gene            8705..9838
                     /gene="ugpC"
                     /locus_tag="SMU_RS07125"
                     /old_locus_tag="SMU.1571"
                     /old_locus_tag="SMU_1571"
                     /db_xref="GeneID:1028806"
     CDS             8705..9838
                     /gene="ugpC"
                     /locus_tag="SMU_RS07125"
                     /old_locus_tag="SMU.1571"
                     /old_locus_tag="SMU_1571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019317477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DT25|3.A.1.1.27"
                     /protein_id="WP_002262979.1"
                     /db_xref="GeneID:1028806"
                     /translation="MTTLKLDNIYKRYPNAKHYSVENFNLDIHDKEFIVFVGPSGCGKS
                     TTLRMIAGLEDITEGNLYIDDKLMNDASPKDRDIAMVFQNYALYPHMSVYENMAFGLKL
                     RKYKKDDINKRVHEAAEILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPL
                     SNLDAKLRVAMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATPNPDKTGSIG
                     RIEQIGTPQELYNEPANKFVAGFIGSPAMNFFEVTVEKERLVNQDGLSLALPQGQEKIL
                     EEKGYLGKKVTLGIRPEDISSDQIVHETFPNASVTADILVSELLGSESMLYVKFGSTEF
                     TARVNARDSHSPGEKVQLTFNIAKGHFFDLETEKRIN"
ORIGIN
        1 ttacaaacta tgccaaatgt ccttatcgta ttgttggatt gttctgtctg atgagaagaa
       61 accagcttta gcgatgtttt gaataacctt tttattccat acattttggt cctcataatc
      121 agctaacatt tcttctttct tagcaatgta ttctttcaag tcaatcagtg tcatgaacca
      181 atctttattg ataagctcat ggtaaagacg ttctaaacgt tcttttttac ctagcgcaag
      241 gacatcctta ctaacgatga aatcaacggc ttctttaatg actgcattat tagtataata
      301 atccttagaa acataagttc ccttgtcata caaatcaata atggtatctg aatccttacc
      361 aaaaatgtag atattatctg aaccgacaag ttcagcaatc tccacattgg caccatccat
      421 cgtacccagt gttaaagcac cgttaagcat gaatttcatg ttacctgtac cagaagcctc
      481 ttttgaagcc aaagaaattt gttccgaaat atcagtagca gggattaatt tttctgccac
      541 agtgacatta taattttcaa caaggaaaac attaaggtaa ggactaacat ccggatcatt
      601 attgataagc tctgataagc aaagaatcaa atgaataatg tcttgggcaa tggtataagc
      661 cggtgctgct ttaccaccaa agatcacagt aattttacgt tttggaagat tgcctttttt
      721 gatttcaaga tacttataaa taacataaag agcattcatt tgctgacgtt tatattcatg
      781 gaaacgcttg atttgcgtat caatgataga attttcatca aggttaattc ccttattttc
      841 cttgagatag cgtttaagag ctaatttatt gttaaatttg atttttgcca gctgctcatg
      901 aacagtcttg tcatccgcaa aagccaataa tttttcaagc tcagtcgcat cttcaagata
      961 accttcacca attaattctt taatataggc tgccaagtct tgattggcaa attccaacca
     1021 ccgacggaaa gtaatcccat tagtcttgtt attgaatttt tcaggataaa tatcatagaa
     1081 gggtttcaat tcactgtttt tcaaaatatc agtatggaga gcagcaactc cgttaacact
     1141 ggttgaaaaa tgaatatcca tgtgagccat gtgaacccga tcatctctat cgataatttg
     1201 aacagcatca tccttatact gactgcgaac gatacggtct agatgttcaa taatggttac
     1261 caaatgtggg acaacttcat ttaaatattc caaaggccat ttttcaagag cttctgctaa
     1321 aatcgtatgg ttggtataac caatcatatt tttcacaata tctacagctt catagaaatc
     1381 taaaccatgt ttttcattca agagacggat aagctctgga ataaccattg atggatgggt
     1441 atcgttgatt tgcacatagg cataatcagc caagtcatgc agatttgaac cgcgctcaag
     1501 cgcttcgtca atcaagagct gtgctgcatt tgaaaccatg aaatattgtt gataaatacg
     1561 cagcaattcc ccatttttat cagaatcatc aggataaagg aaaagagtca gatttttctt
     1621 aatttcagtc ttatcaaaag taataccatc cttaatcaag ccataatcaa gaccatcaat
     1681 atcaaagaga tttaagtaat tcttactatc cttgtgatag cccaaaatat caatacgatc
     1741 taattttgac ttaagcgtaa aatcacggaa aggcacatca tatgaaatag ccgttggcac
     1801 tagccaagaa tcatcttcaa tccagtaatt gggttcagct tcctgctgat tatcacgaaa
     1861 aacttgctta aaaagtccgc agtggtaatt aagtccaaca ccttcaccat taatacccag
     1921 cgttgccatc gaatcaataa aacaagaagc taagcgtccc aaaccaccgt taccaagtga
     1981 tggttctaat tccacatctt ctacttggct gatggactta ccagcagcag ctaattcatc
     2041 cttaacggtc ttataaagac ctaaatttat cagattattt gacagtaatt tcccaatcag
     2101 gaactcagca gagatataat atactttacg tttagacgta tttttaggca tgtctttggc
     2161 agcctctttg acaaagtgca aaagctgaac ataaatagct tcattgctta attgttccaa
     2221 attttgaccg gttttttctt ggacatactt actgaattgt tttgtttttt gtgtcatttt
     2281 cttcatttcc tctttgataa agtttcgtta atttacttaa aaagtttatt ttatcttgtg
     2341 ttaaatcttt tgctctcatc cgccattgcc agttaccgcc gattgttgat ggggtattca
     2401 ttctagagct ggctggctta ttgagcaaat cctgcatggt taaaatagct gtattgctga
     2461 cagttgaaaa gagcagtcta agcatagcct gattaaccgg ctcaattggc ttacgattag
     2521 tataagcatc cacaaattct tcttgctcaa cagtaagacg atcataccaa ccattgacaa
     2581 catcattatc atgcgtccca atataagcaa cactattttg aacataatgg tggggaatat
     2641 caacactgcg gccgcttaaa tcatagaaac caaattctaa aattttcatg cctggaaagc
     2701 ctgtttcttt tagaagctgt ctggctctat catctacgta acccaaatcc tctgcaataa
     2761 ttggcatatc gcccaaaaca ttttgaacag ccctaaagag agcaatacca ggtcctggat
     2821 gccagctgcc attttttgca gttttggaat tacctttaat ttcccaataa tctgagaaac
     2881 ctttaaagtg atctatccgt aagatatcat agatcttaaa actttcttga atacgataaa
     2941 tccaccaagc aaagcctgtt tctcgatgct ttttccaatc ataaatagga tttccccaca
     3001 actgaccctc atcactaaat tcatcgggcg gacagccagc aaccgacaaa ggctgcaagt
     3061 catcatccat cttaaagagt tcaggcatag tccagacttc aacactgtct ttagctacat
     3121 agataggcat atcgccaata attttgatct tatttttatt agcataagct ttcagcgcca
     3181 gccattgttc gaagaagaag tactgtgtaa ccttatggta gctaatttca tcggccaaca
     3241 aatgacgata acgtaccaaa cgctcctcat cacggcgaat agccttttta tcgccccact
     3301 cttgcaaaga cttattgcca aaatgctcct tgatggccat aaattcagca tagtcatcaa
     3361 gccaagtttc atttttttct tcaaacaaag ctaatttttt cagattagtc ttgtctgcca
     3421 gaaaattgat aacagccttt tccaaaattg gccgacgtac tttaaataat agagcataat
     3481 caacaatttc ttcgtcttct ccaaaagaaa cagaattata gtcatcctcg tccaataagc
     3541 cagcttcttg taatttctta aaatcaataa aattcacatt accagcaacg gcagaaaaag
     3601 attggtaagg agaatcacca taactcgttg tcgttaaggg taagagctgc caatatgttt
     3661 gacctgtttt ttttaggaaa tcaacaaaat cataagcttc ctgcccaaaa gtaccaattc
     3721 caaattttcc cggtagagaa ctgatatgca tcaggatacc acttgcgcgt ttttccatat
     3781 agtctcctcg cttttttatt atcattcata gaaaaagtat aacgcaatcg tttgcataag
     3841 tcaagaattt tttcaaaaaa taaaaaaagc ttagaaatta agcttctaat ctctagcttt
     3901 ttttaagatt acggacactc tcacgttttt tcaaagtaaa aggaacgatt actttctgat
     3961 cttttgactg acgcttttgc actttttcca acaaacaatt cagactcgct cttcctaaac
     4021 gattaacatt aatatcaaat gttgttaaat aaggatgcaa aatagtggca taactggaat
     4081 tattaaaaga cacaatagac atatcttctg gtacagctat accataataa gacaaaaatt
     4141 gaataatccg aagagaaacg acatccccaa taataaggag agccgttatt ttttttttct
     4201 gaacagtttt aataaaggct tctagcgtgc tagcttgttt agaatcaaaa agagcactgt
     4261 catatgactg taaacctaat gcttgcattc ccttttgata gccgataaaa cgctcaatat
     4321 aaacatcact ttcttgatca tttgtgacaa ataaaatctg cttatgccct ttttgattga
     4381 ggtaagtcac agcagtctca gccattaatt ggttatcatt atcaacatag gtcgtttcat
     4441 ctttataatc aactggagca ccgacaatga caaaaggaat tttatttttg atcagatatt
     4501 gacgtacagg atcccttctt tctgagtaaa gcacgataaa accatccact cgcccttgcc
     4561 gatacatgag ctgtacctga tcttttagat ccgtcaaagt attactggtc gcaatcgaaa
     4621 ctgtgaattt attacggctt gcttcattat taatagctgc caatatttcc atgaaaaaag
     4681 gttcgcttaa acgatctgga cttgttaaag gcgggaaaac aacaccgaca cagtgagtca
     4741 agccactagc cagcatttga gcagctaaat taggcacata acctaaatct gtcatagcct
     4801 gttgaaccct atctttcgtt ttttgcgaaa tggaggaact gttttttaaa acccgactga
     4861 cagtagaagg attcacacct gcctcttttg caacatcctt aatagtaacc atatactttt
     4921 cctttattta atgaatctat tttacaacag ttctgctctg cttgcaagat tgttaacctt
     4981 ttatattttc caagaatcag atattaacca gattgaagaa aaagtctttc tttaagactt
     5041 tccttataaa gtaatttaat atcttgatga aattttaaaa aaacttgaca tttttcgcaa
     5101 acgattgcat aatattattg taacaaaaat tacaaagaaa tttcaggagg aaatcgctat
     5161 gaaaacatgg caaaaaatcg tcgttggcgg tgcaggcctt atgcttgcaa gcagtattct
     5221 tgttgcctgt ggatcaaagg attcaaaatc aagttcatct gatcccaaaa ccattaaact
     5281 ttgggttcca acaggagcca agaaatctta tcaaagtatt gttcacaaat ttgaaaagga
     5341 ttctaactat aaagtaaaga ttattgaatc tgaagaccca aaagctcagg aaaagatcaa
     5401 aaaagatcct agtactgctg cagatgtttt ctcgctgccg catgatcagc tgggccagtt
     5461 agttgactct ggtgttatcc aagagattcc tcaaaaatat tcaaaagaaa taaataaaaa
     5521 tgaaacacag caggctgcaa caggagctat gtacaaaggt aagacttatg cttttccttt
     5581 tggaatcgag tctcaagtac tttactataa taaatcaaaa ctctcagctg atgatgtcac
     5641 atcatatgag actattacca gcaaggcaac tttcggagca aaattcaaac aagttaatgc
     5701 ctatgcgact gcaccacttt tctattcagt aggtgataca ctctttggta aaaatggcga
     5761 agatgccaaa ggaactaact ggggaaatga tgctggtgta tctgttttga aatggattgc
     5821 cagtcaaaaa ggtaacgctg gctttgtcaa tcttgacgat aacaatgtca tgtctaaatt
     5881 tggtgatggt tctgtagctt cttttgaatc aggtccttgg gattatgaag ccgcacaaaa
     5941 ggcagttggc aaaaacaacc tcggtgttac ggtttatcca acaataaata ttaatggtca
     6001 agaagttcaa cagaaagctt tcttaggtgt taaactctac gctgttaatc aagctccttc
     6061 taaaggaaat accaaacgta ttgctgctag ttataaatta gcttcttact taacaagtgc
     6121 tgaaagccaa gaaaatcaat ttaagacaaa aggacgcaac atcatcccat ctaataagac
     6181 cgttcaaaac tctgatacag tcaaaaatca tgaactcgca caggctgtta tccaaatggg
     6241 atcttcttca gattatactg ttgttatgcc taaactcaac caaatgtcaa cattctggac
     6301 ggaaagcgca gctattctta gtgatactta caatggtaaa attaaagaaa gtgattacct
     6361 tgctaaatta aaacaatttg ataaagattt agcagctgct aaataaaaca tcataagtga
     6421 ggggattaaa tcttctcact tattctttta actgaattaa taataaagta aaggagataa
     6481 atatgattca gtcatcttct catgatcagt tatctgtact tgaaactttt aaaaagggcg
     6541 ggatagatat caaattatcg tttgtcatca tgggatttgc caatttgatg aataagcaat
     6601 tcataaaagg cctcctcttt ctattaagtg agatagcttt tctaattgct tttgtcacac
     6661 aggttattcc agctttttca ggcttactca ctctcggtac taaaacacaa gggatgcaag
     6721 aaaaaattgt ggatggcgtt aaattacagg tggcagttga aggcgataat tcgatgctga
     6781 tgctcatttt tggattagcc tcactaatct tttgtttggt ttttgcctac atttattggt
     6841 gtaatcttaa aagtgccaga aatctctata tgttaaaaaa agagggacgt cacattccat
     6901 ctttcaaaga agattttatg actttggcaa acggccgatt ccatatgact ttgatgttta
     6961 ttcctttgat tggtgttctt ctttttacca ttttgccact cgtttatatg atttgcctgg
     7021 cctttaccaa ttatgatcac aatcatcttc cgcctaaatc cctttttgat tgggtagggt
     7081 tggctaattt tggtaatgtt ttgaatggcc gcatggctgg aaccttcttc cctgtccttt
     7141 cttggacact tatctgggct gttttcgcaa ctgtgacaaa ctttcttttt ggagtcatct
     7201 tggcacttat tatcaatgct aagggattaa aattgaaaaa aatgtggcgg actatctttg
     7261 ttattaccat tgctgtgccg cagttcattt cacttttgct gatgagaaat ttccttaatg
     7321 atcaaggtcc gctcaatgct ttcctagaaa aaattggcct gatttctcat tctctgccat
     7381 ttctatcaga tcctacttgg gcaaaatttt caattatctt cgttaatatg tgggttggta
     7441 ttccttttac catgttagtc gcaacaggaa ttatcatgaa tcttccgagt gagcaaattg
     7501 aggctgcaga aattgacggc gctagtaagt tccaaatttt taaatccatc actttcccgc
     7561 agattctttt aattatgatg ccatctttaa tccagcaatt tattggaaat atcaataatt
     7621 ttaatgtcat ctacctttta accggtggcg gaccaactaa ttcacaattc tatcaagcag
     7681 gcagcacaga cttattggtc acttggcttt ataaactaac aatgaatgct gcagactata
     7741 atttagcttc tgttattggt atctttatct ttgccatttc agctatcttc agtcttttag
     7801 cttatacgca tacagcatca tacaaggaag gagctgttaa ataatgaaaa gaaaaaaaca
     7861 acttcagatc ggctctatct atgctttact gattctctta tccttcattt ggctatttcc
     7921 gatcatttgg gttatactga cgagttttcg cggtgaaggc acagcttatg ttccttatat
     7981 tattccaaaa acgtggactt tagataatta tattaaatta tttaccaatt cttctttccc
     8041 atttggacgc tggtttttaa ataccttaat cgtttcaaca gccacttgtg ttctgtcaac
     8101 ttctatcaca gtggcaatgg cttattcgct tagccgtatt aaatttaaac accgtaacgg
     8161 ctttttaaaa ttagctcttg ttctgaatat gtttccggga tttatgagta tgattgcagt
     8221 ttactacatt ctaaaagcac tcaatctcac ccaaacatta acatctcttg ttttggtcta
     8281 ttcttcagga gctgccttaa ctttctatat cgctaaaggc ttttttgata cgattcctta
     8341 ttcattggat gaatcagcta tgattgatgg ggctacgcgt aaagatattt tcttaaaaat
     8401 cactctgccg ctatctaagc ccatcatcgt ttatacggcc ctgttggcat ttattgcccc
     8461 ttggattgac tttatttttg ctcaggttat tcttggagat gccaccagca aatataccgt
     8521 agcgattgga ctcttctcta tgcttcaagc tgataccatt aataattggt tcatggcctt
     8581 tgcagcaggt tctgtactga tcgccattcc aatcacgata ctttttatct tcatgcaaaa
     8641 gtattacgtt gaaggcatta ctggcggatc tgttaaataa aaaagaaagt aaggaaacga
     8701 tattatgaca actttaaaac ttgataacat ctacaaaaga tatcccaatg caaagcatta
     8761 ttccgttgaa aattttaatc ttgacattca tgataaagaa tttattgtct ttgtcggtcc
     8821 ttcaggatgc ggaaagtcaa ccactcttcg catgattgct gggctggaag atattacaga
     8881 aggcaacctt tatattgatg ataaactcat gaatgatgcc tctcctaaag atcgcgatat
     8941 tgctatggtt tttcaaaatt atgctcttta tcctcatatg agcgtttatg aaaatatggc
     9001 ttttggccta aaacttcgta aatacaaaaa agatgatatt aataaacgtg tacacgaagc
     9061 tgctgaaatt cttggactga cagaatttct tgaaagaaag cctgcggacc tctctggcgg
     9121 acagcggcag cgggttgcta tgggacgtgc tattgtccga gatgctaagg tcttcttaat
     9181 ggacgaacct ttgtcaaatt tagatgccaa acttcgagtt gccatgcgag ccgaaatcgc
     9241 taaaattcac cgccgcattg gggcaacgac tatctatgtt acccatgacc aaacagaagc
     9301 catgacctta gcagatcgta ttgttatcat gagcgctact ccaaacccag ataaaaccgg
     9361 ctctatcggt cgtattgagc agattggaac accacaggaa ctctacaatg aacctgctaa
     9421 taaatttgtt gctggcttca tcggaagccc cgctatgaat ttctttgaag tgaccgttga
     9481 aaaagagcgt ttggttaacc aagatggtct aagccttgcg cttcctcagg gacaggaaaa
     9541 aattcttgag gagaaaggtt atcttggtaa aaaagtcact ttaggtattc gaccagaaga
     9601 catctcaagt gatcaaattg tccacgagac tttcccaaat gccagtgtta cagctgacat
     9661 actagtatca gaacttttag gcagcgaaag catgttatat gtcaaatttg gcagtactga
     9721 atttacagct cgcgtcaatg ctcgtgactc tcacagtccc ggagaaaaag tacaattaac
     9781 ctttaatatt gctaagggac acttctttga tttagagact gaaaaacgaa tcaattaa
//
