LOCUS       CP028460               10948 bp    DNA     linear   BCT 22-OCT-2018
DEFINITION  Bifidobacterium animalis subsp. animalis strain CNCM I-4602
            chromosome, complete genome.
ACCESSION   CP028460
VERSION     CP028460.1
DBLINK      BioProject: PRJNA445301
            BioSample: SAMN08774047
KEYWORDS    .
SOURCE      Bifidobacterium animalis subsp. animalis
  ORGANISM  Bifidobacterium animalis subsp. animalis
            Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
            Bifidobacterium.
REFERENCE   1  (bases 1 to 10948)
  AUTHORS   Egan,M., Bottacini,F., O'Connell Motherway,M., Casey,P.G.,
            Morrissey,R., Melga,S., Faurie,J.-M., Chervaux,C., Smokvina,T. and
            van Sinderen,D.
  TITLE     Staying alive: Growth and survival of Bifidobacterium animalis
            subsp. animalis under in vitro and in vivo conditions
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10948)
  AUTHORS   van Sinderen,D., Chervaux,C. and Smokvina,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2018) School of Microbiology, University College
            Cork, Western Road, Cork ND, Ireland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method        :: SMRT Analysis v. 2.3
            Expected Final Version :: yes
            Genome Coverage        :: 400.0x
            Sequencing Technology  :: Pacbio SMRT sequencing
            ##Genome-Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..10948
                     /organism="Bifidobacterium animalis subsp. animalis"
                     /mol_type="genomic DNA"
                     /strain="CNCM I-4602"
                     /host="Homo sapiens"
                     /sub_species="animalis"
                     /db_xref="taxon:302912"
                     /country="France"
                     /collection_date="01-Oct-2014"
     gene            1..957
                     /locus_tag="CNCMI4602_1521"
     CDS             1..957
                     /locus_tag="CNCMI4602_1521"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AYN24349.1"
                     /translation="MKIDSQIERLLDESQNAHRCAVTTDVNLRRKLRRRCESGELTMPY
                     PQLFARKETWDALNPREKKRHVILALAMVRPDWIFCAQSAACLYGIEQSYQIHDNPMIH
                     IASTHESGIYRARRSDAVMHRVYTPNPQYNVINGAKVTTLPCTIYQCALVLPFEQILPL
                     ADSAVRSGMALDDLRQFPVHSATEALAIGNVLEYTDPRSENGGETLARSRFIERGLMIP
                     QLQKEFPNPQNPEYPFRVDFIWILPDGRMIVAEYDGMTKYGNDRKTIANRVHREKLRDE
                     ALRQHGVTAIIHFDYEDLLNPNELIAKLVAAGVPYRR"
     gene            complement(1302..3194)
                     /locus_tag="CNCMI4602_1522"
     CDS             complement(1302..3194)
                     /locus_tag="CNCMI4602_1522"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="AYN24350.1"
                     /translation="MITVRSVVAHTECGPFDERGEVELPPDSVSEHKIPWRTLRSATVT
                     EISAQLPESNPILEHPTLLAGRSVSVRLQLGRLKPVGQILCLYQHKEWWMRPAWVEHFC
                     DIPERTQLVLWKSAKAWHVMMPVFRHEMRVDIRGDGRGHNDLLLDVSTNQVDRVQLQGP
                     LLVHRQSDRKVEDPYELIRGCAEWVMSQNGGLGRLWKQTLPESLRGFGWCTWDSLGTNV
                     SEQAIIAKMEEFAAKHVPVSWVLIDDGWSQVENGKLTGFDADTTRFPQGLSHTIDVLKH
                     DFGVRYVGVWQAFQGYWHGVDVDALAGKPESDDDWYEYYKQEYPYGDARVEDPKLLVSR
                     SAFETLPNGMAIPTANPECAALFWRTWNTHLDGAGIDFVKVDSQGTLPVLTRGLESYAS
                     LGVRHDAVEYATNWIRHEDDNGDWEYAHLAVIHCMGMTPENYWQRCAEGVARTSDDFFP
                     NIPESLTEHAIENAYCSLLMGCLCYCDWDMFWTRHPHARTHMLLRWISGGPIYCSDKLG
                     ETDSDLLAPLFDADGNLTHPDGVGVPVLDSLLADPVHGDVPLGIRNTFRGDEVLLFVGL
                     NADAPQTAHIRATESPLTVFDPQTGGRVHLSIGEDLALTLHYGECELRVLQPLT"
     gene            complement(4113..5018)
                     /locus_tag="CNCMI4602_1523"
     CDS             complement(4113..5018)
                     /locus_tag="CNCMI4602_1523"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00751|3.A.1.1.28"
                     /protein_id="AYN24351.1"
                     /translation="MTTATANTMSQQSAQQSATMNTAPAKAEKFRKDRRINWWLTAVVA
                     VFSLTILVPLYFTVVTALKTPAEAGSFSLPTSWQWGNFAAASAKVDYPRAALNSAIITV
                     LAVSLTLVTNTFVAYAIARNMDKRFFRFLYYFFIAAMFVPFPVVMLPLAKQMGSWHLDN
                     QAGLIVLYVILGLGTNLFIATGFIRSIPVSLEEAARIDGAGTWRIFWKIIFPLMGPINA
                     TIAIMTALWAWNDFLLPLIILTDQSNQTIPLAQYVFSSQFATNYPQAFASYLMAMAPVL
                     VVYIFAQKWVVGGVMRGAVK"
     gene            complement(5024..6016)
                     /locus_tag="CNCMI4602_1524"
     CDS             complement(5024..6016)
                     /locus_tag="CNCMI4602_1524"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00750|3.A.1.1.28"
                     /protein_id="AYN24352.1"
                     /translation="MTSLANADQQARAMEDVLANDIDTHHSRTPAGKPPSKRRVSAFSR
                     RKVDHAYYWMAVPAAVIFAVFLYVPFVRGIMYSFTNSQGYGSYNWIGFQNYVALFRDER
                     VGHAYLFTFLIAIAITVLINVIALFLSVALNGKIACKNGFRAIYFIPYTLAVLVIGYVF
                     KYIFMQPLPELGKALGIGWLSESLLTSERYAWIPIVFLAVWQGVAYSVLIYLAGLQTVD
                     SEVYEAAAIDGVNAWQKFWKITFPLIGPFFTINLVLTMKNALGTFDQVVALTDGGPNSK
                     TETVTYLIWKGGLTGGEYAYQTANAVLFFIVLAIIAFIQLKFFGSKEKV"
     gene            complement(6050..7312)
                     /locus_tag="CNCMI4602_1525"
     CDS             complement(6050..7312)
                     /locus_tag="CNCMI4602_1525"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00749|3.A.1.1.28"
                     /protein_id="AYN24353.1"
                     /translation="MRRMLRGIGAAVCALAVGVGAAGCGNSAGSGQVTLDFFQFKAEAA
                     DWFEEAAQEFEKENPDIRININNSANAQTDLRTRFVKDRVPDVITFNGDYSFGTFAASG
                     VFHDFTDDPLVNDLNEGMVNIAKNLVQTSDPAKKRLYGLPFAGNASGYIYNKDLFRKVG
                     LDPDDPPQTWDEFIAMLKKFRDAGINPVQATLADAWTTQAPLASLAGTLVPESEYAALK
                     SGDTTFKQIWTEPIEKEIELFKYADSEKGVTYQQGTQNFAKGAAAIIPLGTYAIPQITM
                     INKDIDLGFAQMPATNDAGKQILTAGDDVILTMGANSRHKEQSMRFIRFLMSKKQLEDY
                     ADAQSAITPLKETYFGNKALEPVRPFFESNRVADFCDHYIPSSINIGGYLQSAIMSGNV
                     NQFIDSMQNEWNKVQARDFRK"
     gene            7493..8701
                     /locus_tag="CNCMI4602_1526"
     CDS             7493..8701
                     /locus_tag="CNCMI4602_1526"
                     /codon_start=1
                     /transl_table=11
                     /product="NagC-type transcriptional regulator"
                     /protein_id="AYN24354.1"
                     /translation="METNSDSLDFPRWFSRSDATHNVARGIMQYGPIARTPLAQIFNLS
                     QGALSRITSDLIYDGVIEEMPAGSTQAGRLPQGFDLRESGERRGRPQTALRIREDSHAF
                     VGVNIHDGAITVSEVNAVCHPIGSDITETVSNTAPQAVVEQITRMVRELAASSPDAPSP
                     TALGLSLGGHVEDDRYVTFAPFLYWDSTVDLGGMLQRATGIPTKVFNDLDSVLLHECWF
                     GDAIGVPRFAVITMGAGVGYSISDHGDPIDNPDKSYGLAGHVLIDPEGPRCSSGHIGCS
                     QCLTSDSIAEEYSGIMGHVTTFEEFSHDLRANRPQARRLAERTCYRLGVLVATVSNLAM
                     PSRVLVSGESSFIAKKNREFIRKGIDAYRHSQAAPVEFSIPQFSWRLWSDSAAARTIAT
                     YIR"
     gene            complement(8726..10948)
                     /locus_tag="CNCMI4602_1527"
     CDS             complement(8726..10948)
                     /locus_tag="CNCMI4602_1527"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="AYN24355.1"
                     /translation="MTQISEFNATTHAGEALHVVSMENHDADSAFALAFVADELPRVVH
                     WGRPLTQPRTLVSAVDALRPQRVSGALDETTWPSVLPTPAEAWTGEPRFVVRRDGVELF
                     CRFVVTDTAVGDAGVAVTASDAEQGVEITWTCEMRDSGLVRQRADVRNLGAGNLEIGKV
                     ELGFPVPADMTELLTTTGHHLRERSPQRQPLTIGRFQKASMVGRPDFDASLLLNAGRPG
                     FGFTHGDVYSVHVAWSGNSLMSAERLPYTTGVIGGAEVLAGGEITLHDSADSYTTPWLY
                     GSHGEGLNEVAARFHADLRATHARWRAEHGIAGKPRPVILNTWEAVYFDHDYHTLVKLA
                     DKAAASGVERFVVDDGWFGDRRGDTAGLGDWQISQEVWPDGEHSLKALADYVHAKGMEF
                     GLWFEPEMVNPDSAMYREHPDWVLMPTAHRLPMQGRNQQVVDLTNPEAYAYVYGCMDSL
                     VGELGIDYIKWDHNKYVTEAASPRTGRPAVHGQTLAVYRMFHDLKTSHPGLEIESCSSG
                     GGRVDMGILELADRIWASDCVDPVERADIQRYTSLLVPPEMIGEHVGASPAHSTHRATS
                     QEMRMAMAFFGHLGIEWNLLKEPQHDLDLLGEWVRAYKEHRVDFEHGVAVHGDAADPAV
                     RVDGVISADGARAVYRFTQLTTSQTYPAAPVALPGLDAHATYRVRPLALNMASGEPFSE
                     IGNGQSELGWWNANGVEMTGEALASYGLRPPSIHPANAVLFSVTRV"
ORIGIN
        1 atgaaaatag attcgcaaat cgagcgactc ctcgacgagt cccagaacgc acaccgatgc
       61 gcggtgacga ccgacgtcaa cctgcgccgc aaactacgcc gcagatgcga aagcggcgaa
      121 ttgaccatgc catacccgca actgtttgcg cggaaggaaa cttgggatgc gctcaatccg
      181 cgcgagaaaa agagacatgt catactcgcc ctggcaatgg tgcgccccga ctggattttc
      241 tgcgcacaga gcgcggcttg cctgtacggc atagaacagt cgtaccagat tcacgacaat
      301 ccgatgatcc acattgcatc cacacacgaa agcggcatat accgggccag gcggagtgat
      361 gccgtgatgc accgcgtgta cacgccaaat ccgcaataca acgtgatcaa tggagccaag
      421 gtcaccacac tgccgtgcac gatctaccaa tgcgcgctcg tgctgccgtt cgaacagata
      481 ctgccgctcg cagattccgc agtacgcagc ggtatggcgc tcgacgatct gcgacagttc
      541 cccgttcaca gcgcgaccga ggcactcgcg atcggcaacg tgctcgaata caccgacccg
      601 cgcagtgaga acggcggcga aacgctcgca agaagccgat tcatcgaacg cgggctcatg
      661 attccacagc tgcagaagga gttcccgaat ccgcagaacc cggaataccc gttccgcgtt
      721 gatttcattt ggattctgcc agatggacgc atgattgtcg ccgaatacga cggcatgacg
      781 aaatacggca atgaccgcaa gaccatcgca aaccgcgtgc acagggagaa actgcgcgac
      841 gaagcgctgc ggcaacacgg cgtcaccgcg atcatccatt tcgattatga ggatttgctc
      901 aatcccaacg aactcattgc caagctcgtc gccgccggcg tgccgtaccg ccgctaagca
      961 tgcagcggat ctggtcgcga catggtatgc ggaagattcc gagaaccgtg ccgcaaacgt
     1021 cgacttttgc ggtcgatcat gcggaagact ccgtaaaccg tgcctcaaaa ggcatcccgc
     1081 gcggcatggc ttacggaagg ttccgagagt cgtaccgcaa acggagactt ccgcggtcag
     1141 tcttacggaa ggttccgtga aagcgactat attcaggatt caggtcactt tgcggtcgaa
     1201 tatacggacg actccgaaaa acagaccacg aaacggggtc tgtgcggtac agcttacgga
     1261 agactctgag agctgtgccg aaaatgcatg cgggcgccgg attacgtaag aggctgcaat
     1321 acgcgcagct cgcactcgcc gtaatgcagc gtgagcgcga ggtcttcgcc gatgctcaga
     1381 tgcacacgtc cgccggtctg cggatcgaac accgtgagag gagattccgt cgcgcgaatg
     1441 tgggcggtct gcggggcatc ggcgttcaat ccgacgaaca gcagtacctc gtcgccgcgg
     1501 aacgtattgc gaatgccgag tggaacgtcg ccatgcaccg ggtctgcgag cagactgtcg
     1561 agcaccggca cgccgacgcc gtccggatgc gtgagattgc cgtcggcatc gaacagcggg
     1621 gcgagaagat cggaatcggt ctcgccaagc ttgtcggaac agtagatcgg gccaccgctt
     1681 atccagcgca acagcatatg cgtgcgcgcg tgcgggtggc gggtccagaa catatcccag
     1741 tcgcagtagc agaggcagcc catgagcagc gaacagtacg cgttctcgat ggcatgctcg
     1801 gtgagcgatt cgggaatgtt cgggaagaag tcgtcgctcg tgcgggcgac tccctcagca
     1861 cagcgctgcc aatagttctc gggagtcatg cccatgcagt ggatcacggc gagatgcgcg
     1921 tattcccaat caccattgtc atcttcgtga cgtatccagt tggtggcgta ttccacggca
     1981 tcatggcgaa cgcctagaga cgcataggat tccaggccgc gtgtgagcac aggaagtgtg
     2041 ccctgcgaat ccaccttcac gaagtcgatg ccggcgccgt ccaagtgcgt gttccatgta
     2101 cgccagaaca gcgctgcaca ctccggattc gcagtgggga ttgccatgcc attgggtagt
     2161 gtttcgaacg cggatcggct cacgaggagc ttgggatcct caacgcgcgc gtccccatac
     2221 ggatactcct gcttgtagta ctcgtaccaa tcatcgtcgg attcgggctt gccggcgagc
     2281 gcgtccacat ccacgccatg ccaataccct tggaacgcct gccatacgcc gacgtaccgc
     2341 acgccgaagt cgtgtttgag cacgtcaatg gtatgcgaga gtccctgcgg gaagcgcgtt
     2401 gtgtcggcgt caaaaccggt tagcttaccg ttctcgactt gagaccaacc gtcgtctatg
     2461 agcacccacg aaacgggcac gtgtttggcg gcgaactcct ccattttggc gataatggcc
     2521 tgctcgctca cgttcgtgcc gagcgagtcc caggtgcacc agccaaaacc gcgcaacgat
     2581 tccggcagag tctgcttcca caatctcccc aagccaccgt tctgcgacat gacccactcc
     2641 gcgcatcccc gaatcagctc gtaaggatcc tcgactttcc gatcgctttg ccgatggacg
     2701 agcagtggcc cctgcaattg cacacggtca acctgattcg tggagacatc gagcagcaag
     2761 tcattgtggc ctcgcccatc gccgcgaatg tcaacgcgca tctcgtgacg gaacaccggc
     2821 atcatcacat gccacgcctt cgccgatttc cacagcacca gctgggtgcg ctccggtatg
     2881 tcacagaaat gctcgaccca tgccggccgc atccaccatt ccttgtgctg gtaaaggcac
     2941 agaatctgcc ccactggttt caatctgccc aattgcagcc gtacggacac cgaccgcccg
     3001 gccagcaatg tgggatgctc gagaatcgga ttggattccg gcagctgcgc acttatctcc
     3061 gtcaccgttg cgctacgcag tgtgcgccac ggtattttgt gttcgctcac cgagtccggg
     3121 ggcagttcga cttcgccgcg ctcatcgaac ggcccgcatt cggtatgcgc caccaccgat
     3181 ctcaccgtta tcatgggcgt ctccctcctg ccgttcttcg ttgacctgca ttggttcccg
     3241 ccacaataac cagctttggc tgccgtttcc agcccgccac gccgagcgtc attactccct
     3301 cagcaaaaca gcagcgcgca ctgcctaacg cgcatttgct tgcaactccg gtctcatgcg
     3361 ggcaatctga acatgcactc gggtgtcgtt attgcaatcg gatctcagat tggctcttgg
     3421 atcgcagatt atctcgccgt atttgcaaac gcagtctcat catgggcgac tatgacgcgt
     3481 ctgcctggtc ccagcgagac cgcagctgca ggacaggcaa tctaggagcg cgcagacgtg
     3541 cctttcttgc aaacccgact atggcaaggc gctcgcgagc cgcttgctgt gccatatttg
     3601 caaactcagt ctcaatttgc agatcttaat atgcagatgc agccatagat tcccgcactc
     3661 ccggatacgc atctgcaatc tgcgtaaatg tgtaaaaagg gacatcgcgg acccgtgcac
     3721 gtccccaatt acgcaaaaca acagggcaac agaacacagg cgatcgccgc cgaaagacgc
     3781 ggtgcccgct acaactctgc aggaaagaac tctgcgtgaa agggaacgct agctctgcgt
     3841 aaaaagagac atctccgacc cacagatgtc ccaaattacg caaaggatga aaaggaagaa
     3901 ggggaaagca gagacaaaga attactgaaa gtaatagtct gcgtaaaagg ggacagatag
     3961 aacgcctatc tgtccccttt tacgcagatg cgctagccgc ccatgcactg gccgcagacg
     4021 gaccggtcgc cgctgcgctg gccgcagatg cgctacccgc agacgcccgc ccgctccact
     4081 cccgcagcgc agtcggcaga acgggtcgcg ggttacttca cggcgccgcg catcacaccg
     4141 ccgacgaccc acttctgggc gaagatgtag acgacgagca cgggggccat ggccatcagg
     4201 tagctcgcga acgcctgcgg gtagttcgtg gcgaactgcg agctgaacac atactgtgcg
     4261 agcgggatgg tctggttgct ctgatcggtg aggatgataa gcgggagcag gaagtcgttc
     4321 catgcccaca gtgcggtcat gatcgcaatc gtcgcgttaa tgggccccat gagcgggaag
     4381 atgatcttcc agaagatgcg ccatgtgccc gcgccgtcga tgcgcgcggc ctcttcgagc
     4441 gacaccggga ttgagcgaat gaatccggtg gcgatgaaca ggttcgtgcc aaggccgaga
     4501 atcacgtaca agacaatcag gccggcctgg ttgtcgaggt gccacgagcc catctgcttg
     4561 gcgagcggca gcatgaccac cgggaacggc acgaacatcg cagcgatgaa gaagtagtag
     4621 aggaagcgga agaaacgctt gtccatgttg cgcgcgatcg cgtaggcgac gaaggtgttc
     4681 gtcacgagcg tgagcgagac ggcgagcacg gtgatgatcg ccgagttgag cgcggcgcgc
     4741 gggtagtcca ctttggccga ggcggccgcg aagttgcccc actgccagct cgtcggcagc
     4801 gagaacgagc ccgcctccgc cggcgtcttc aatgcggtga ccacggtgaa atacagcggc
     4861 acgagaatcg tgaggctgaa cacggcgacg accgcggtga gccaccaatt gatgcggcgg
     4921 tccttgcgga acttctccgc tttggccggc gcggtattca tggttgcaga ttgttgcgca
     4981 gactgctgcg acatggtgtt tgcggttgcg gtggtcattg gtatcacacc ttttccttgc
     5041 tgccgaagaa cttaagctga atgaacgcga tgatcgcgag gacgatgaag aagagcacgg
     5101 cgttcgccgt ctggtatgcg tactctccgc cggtgaggcc acccttccag atgaggtagg
     5161 tgacggtctc ggtcttcgag ttcgggccgc cgtcggtgag cgcgacgacc tggtcgaagg
     5221 tgccgagcgc gttcttcatg gtgagcacga gattgatcgt gaagaacggt ccgatgagcg
     5281 ggaacgtgat cttccagaac ttctgccagg cgttcacgcc gtcgatcgcg gccgcctcgt
     5341 agacctcgga gtccacggtc tgcaggccgg cgagatagat gagcaccgaa taggcgacgc
     5401 cctgccacac ggcgaggaac acgattggaa tccacgcata gcgctcgctg gtgagcagcg
     5461 actcgctcag ccagccaatg ccgagcgcct tgccgagctc gggcagcggc tgcatgaaga
     5521 tgtacttgaa cacgtagcct atgacgagca cggccagcgt gtacggaatg aagtagatcg
     5581 cgcggaagcc gttcttgcag gcgatcttgc cgttcagcgc caccgagagg aacagtgcga
     5641 tcacgttgat gagcacggtg atggcgatgg cgatgaggaa tgtgaacagg taagcgtggc
     5701 cgacccgttc gtcgcggaac agggcgacgt agttctggaa cccgatccag ttgtagctgc
     5761 cgtacccttg cgaattcgtg aacgagtaca tgatgccgcg cacgaagggc acatacagga
     5821 acaccgcgaa gatcacggcg gccggaacgg ccatccagta ataggcgtgg tccaccttgc
     5881 ggcgggagaa cgcggagacc ctgcgcttgc tcggcggttt gcccgcgggt gtgcgcgagt
     5941 gatgcgtgtc gatgtcattc gcaagcacgt cctccatggc gcgcgcctgc tggtcggcat
     6001 tggccaacga agtcattttg ctttccttcc cttgtatccc ggccgcagac tacttgcgga
     6061 agtcacgagc ctggaccttg ttccactcgt tctgcatgga gtcgatgaac tggttcacgt
     6121 tgccgctcat gatcgcggac tgcaggtagc cgcctatgtt gatggacgac ggaatgtagt
     6181 ggtcgcagaa gtccgccaca cggttgctct cgaagaacgg gcgcaccggc tcgagcgcct
     6241 tgttgccgaa ataggtctcc ttgagcggcg tgatcgcgga ctgtgcgtcg gcgtagtcct
     6301 cgagctgctt cttgctcatc aggaacctga tgaagcgcat cgactgttcc ttgtgcctgc
     6361 tgttcgcgcc cattgtgagg atcacatcat cgccggcggt gaggatctgc ttgcccgcat
     6421 cgttcgtggc gggcatctgg gcgaagccca agtcgatgtc tttgttgatc atcgtgatct
     6481 gcggaatcgc ataggtgccg agcggaatga tcgcggccgc gcccttggcg aagttctgcg
     6541 tgccttgctg gtaggtgaca cccttctcgc tgtccgcata cttgaacagt tcgatttcct
     6601 tctcgatcgg ttcggtccag atctgcttga acgtggtgtc gccgcttttc agcgcggcat
     6661 attcgctctc gggaaccaat gtgccggcaa gcgaggcaag gggcgcctgc gtggtccagg
     6721 catcggcgag tgtggcctgc accgggttga tgcccgcatc acggaatttc ttgagcatgg
     6781 caatgaattc atcccatgtc tgcggcggat cgtcggggtc gagaccgacc ttgcggaaga
     6841 gatccttgtt gtagatgtag ccggaggcat tgcccgcgaa cggcagaccg tacagtctct
     6901 tcttcgccgg atccgaggtc tgcacgaggt tcttcgcgat gttcaccatg ccctcgttga
     6961 ggtcattcac gagcgggtca tcggtgaaat cgtggaacac ccccgaggcg gcgaaggtgc
     7021 cgaagctgta gtcgccgttg aaggtgatca cgtcgggcac gcggtccttc acgaaacgcg
     7081 tgcgcaggtc ggtctgcgca ttcgccgagt tgttgatgtt gatgcgaatg tcggggttct
     7141 ctttctcgaa ctcctgtgcc gcctcctcga accagtccgc ggcctccgcc ttgaactgga
     7201 agaaatcgag cgtgacctgc ccgctgccgg cactgttgcc gcagcccgcc gcgcccacgc
     7261 cgaccgccag ggcgcacacc gccgcgccga tgccgcggag catgcgtcgc atggccgaac
     7321 gtctcgttcg tgtcgcgaac ttcattctga ctcccttgtc catttccact ttccatcacc
     7381 gaggctccct tacctcgact gacggttgcc agtgtatgga accgcccttt tcattcccac
     7441 ctccctgcgt gccttgaaac cgcgcaagta attggcgtat atttatgtat tcatggaaac
     7501 taattcggat tcgcttgatt ttccacgctg gttcagtcgt tcggatgcca cgcacaatgt
     7561 ggcgcgcggc atcatgcaat acggcccgat cgcgcggacg ccgctcgcac agatcttcaa
     7621 tctgtcgcaa ggcgcactct cgcgcatcac cagcgatctc atttacgacg gcgtgatcga
     7681 ggagatgccg gctggcagca cgcaggcggg cagattgccg cagggattcg acctgcgcga
     7741 gtcaggtgag cgtcgcggcc gcccacagac cgcgctgcgc attcgcgagg attcgcatgc
     7801 cttcgtcggc gtcaacattc acgacggcgc catcacggtg tccgaggtga acgcggtgtg
     7861 ccaccccatc ggcagtgaca tcaccgaaac cgtgtcgaac accgccccac aggccgtggt
     7921 cgagcagatc acccgcatgg tgcgtgaact cgccgcctcc tcccctgacg ccccctcgcc
     7981 caccgcgctt ggtctttcgc tcggcggcca cgtcgaagac gaccgttacg tcaccttcgc
     8041 gccgttcctg tactgggatt ccaccgtcga tctgggcggc atgctgcagc gggccaccgg
     8101 cattcccacc aaggtgttca acgacctcga ctcggtgctg ctgcacgaat gctggttcgg
     8161 cgacgccatt ggtgtcccca gattcgccgt catcacgatg ggcgccggcg tgggctattc
     8221 gatctccgac cacggcgacc cgatagacaa ccccgacaaa agctatggtc tggccggaca
     8281 tgtgctgatc gacccggagg ggccgcgctg ctcctccggg catatcggct gctcgcaatg
     8341 cctgacgtcc gactcgatcg ccgaggaata ctcgggcatc atggggcatg tgaccacctt
     8401 cgaggagttc tcgcacgatc tgcgggcgaa ccggccgcag gcgcgcagac tcgccgaacg
     8461 cacctgctac cggctcggcg tgcttgtggc gaccgtctcg aatctggcga tgccctcacg
     8521 cgtgctcgtc agcggggaaa gctcgttcat tgcgaagaag aaccgcgaat tcattcgcaa
     8581 gggcatcgat gcctaccggc acagccaggc cgcgccggtc gaattctcga ttccgcagtt
     8641 cagctggcgg ctgtggtcgg attccgccgc cgcccgcacc atcgccacct acattcgcta
     8701 gcgaaggcgc ggccgcaatg acgtgctaca cgcgcgtcac gctgaacagc accgcgttag
     8761 cggggtgaat gctcggcggt cgcagaccgt agcttgcgag cgcctcgccc gtcatctcga
     8821 cgccgttcgc attccaccag ccgagttcac tctgcccgtt gccgatctcg ctgaatggct
     8881 cgccactcgc catattcagt gcgagcggac gcacccggta ggtggcgtgc gcgtcgagtc
     8941 cgggaagcgc aacgggtgcg gccgggtagg tctgcgacgt ggtgagctgg gtgaagcggt
     9001 agacggcacg cgcaccgtcc gcgctgatca caccgtccac gcgcacggcc gggtcggcgg
     9061 cgtcgccatg cacggcgacg ccatgttcga agtcgacgcg gtgctccttg taggcgcgca
     9121 cccattcgcc cagcaggtcg aggtcgtgct gcggctcctt gagcagattc cattcgatgc
     9181 ccaggtgccc gaagaacgcc atcgccatgc gcatctcctg gctcgtcgcg cggtgcgtgg
     9241 agtgtgcggg gctggcgccg acatgctcgc cgatcatctc cggaggcacg agcagcgagg
     9301 tgtagcgctg gatgtcggca cgctccaccg gatccacgca gtcggaagcc cagatgcggt
     9361 ctgcaagctc gagaatgccc atgtcgacgc ggccaccgcc cgacgagcag ctttcaatct
     9421 ccagaccggg gtgggaggtc ttcaggtcgt ggaacatgcg gtagacggcg agcgtctgcc
     9481 catggacggc agggcggccc gtgcgcgggg aggccgcttc ggtcacatac ttgttgtggt
     9541 cccatttgat gtagtcgatg ccgagttcgc cgacgagcga gtccatgcag ccgtacacat
     9601 atgcgtacgc ctcgggattc gtcagatcga cgacctgctg gttacgcccc tgcatcggca
     9661 gacggtgcgc ggtgggcatg agcacccagt cggggtgctc gcggtacatg gcggaatccg
     9721 ggttcaccat ctccggttcg aaccacaggc cgaactccat gcccttggca tgcacgtagt
     9781 cggcaagcgc cttgagcgag tgctcaccgt cgggccacac ctcctgggag atctgccaat
     9841 cgcccagtcc cgccgtgtcg ccacggcggt caccgaacca gccgtcgtcg accacgaagc
     9901 gctcgacgcc gctggcggcg gccttgtcgg cgagtttgac gagcgtgtgg tagtcatggt
     9961 cgaaatacac ggcctcccag gtgttgagaa tcaccggccg cggtttgccg gcaatgccat
    10021 gctcggcacg ccaacgcgca tgggtggcgc gcagatcggc gtggaaccgc gcggcgactt
    10081 cgttgagccc ctcgccgtgg gaaccgtaga gccacggcgt ggtgtaggag tccgcggaat
    10141 catgcagcgt gatctcgccg ccggcaagca cttccgcgcc gccgatcaca ccggtcgtgt
    10201 atggcaggcg ctcggccgac atgagcgaat tgccgctcca tgccacgtgc accgaataca
    10261 cgtcgccatg cgtgaagccg aagccggggc ggcctgcatt gagcagcagc gaggcgtcga
    10321 agtcggggcg gcccaccatg ctcgccttct ggaaccgacc gatcgtcagc ggctggcgct
    10381 gtggtgaacg ctcacgcaaa tgatgcccgg tggtggtgag cagctcggtc atgtcggccg
    10441 gcaccgggaa gccgagttcc accttgccaa tctccagatt ccccgcgccc agattgcgca
    10501 cgtccgcgcg ctgacgcacc aggccgctgt cgcgcatctc gcaggtccag gtgatctcga
    10561 ccccctgttc ggcgtcgctg gcggtgacgg caaccccggc gtcacccacc gcggtgtcgg
    10621 tgacgacgaa acggcagaag agctccacgc catcgcgacg caccacgaaa cgcggctcgc
    10681 cggtccatgc ctcggccggc gtgggcagca cgctcggcca tgtggtctcg tcgagcgcac
    10741 cggagacccg ttgcgggcgc agggcgtcca ccgcgctcac cagcgtgcgc ggctgggtga
    10801 gggggcgccc ccaatgcacc acacgcggca actcgtcggc cacgaacgcg agcgcgaacg
    10861 ccgaatccgc gtcgtggttc tccatggaga ccacatgcaa tgcctcgccg gcgtgcgtgg
    10921 tcgcgttgaa ttcggaaatc tgcgtcat
//
