LOCUS       NC_023151               9871 bp    DNA     linear   CON 09-DEC-2019
DEFINITION  Thermotoga maritima MSB8, complete genome.
ACCESSION   NC_023151
VERSION     NC_023151.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02261406
            Assembly: GCF_000230655.2
KEYWORDS    RefSeq.
SOURCE      Thermotoga maritima MSB8
  ORGANISM  Thermotoga maritima MSB8
            Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
REFERENCE   1  (bases 1 to 9871)
  AUTHORS   Noll,K.M., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name :: Thermotoga maritima MSB8, DSM 3109
            collection_date                   :: 1982
            lat_lon                           :: 38.3912 14.9676
            country                           :: Italy
            num_replicons                     :: 1
            ref_biomaterial                   :: DSM 3109, ATCC 43589
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Anaerobe
            isol_growth_condt                 :: 10360571
            assembly                          :: Newbler v. 2.3
            finishing_strategy                :: Level 6: Finished
            environment                       :: Mud
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi08995
            Current Finishing Status          :: Level 6: Finished
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2010
            Gene Calling Method               :: Prodigal 1.4, GenePRIMP
            Isolation Site                    :: anaerobic marine mud
            Isolation Comments                :: isolated by Stetter
            Temperature Range                 :: Hyperthermophile
            Temperature Optimum               :: 80
            Gram Staining                     :: Gram-
            Sequencing Depth                  :: 30x
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Finished
            Current Finishing Status          :: Finished
            Assembly Method                   :: Newbler v. 2.3
            Genome Coverage                   :: 30x
            Sequencing Technology             :: 454; Illumina GAii
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/09/2019 02:10:01
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.10
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 1,945
            CDSs (total)                      :: 1,893
            Genes (coding)                    :: 1,877
            CDSs (with protein)               :: 1,877
            Genes (RNA)                       :: 52
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 16
            CDSs (without protein)            :: 16
            Pseudo Genes (ambiguous residues) :: 0 of 16
            Pseudo Genes (frameshifted)       :: 10 of 16
            Pseudo Genes (incomplete)         :: 9 of 16
            Pseudo Genes (internal stop)      :: 2 of 16
            Pseudo Genes (multiple problems)  :: 4 of 16
            CRISPR Arrays                     :: 7
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            CP007013.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 403117
            Source DNA and Organism available from Kenneth M. Noll
            (noll@uconn.edu)
            Source DNA available from Kenneth M. Noll (noll@uconn.edu)
            Organism available from Kenneth M. Noll (noll@uconn.edu)
            Contacts: Kenneth M. Noll (noll@uconn.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline (PGAP)
            set; GeneMarkS-2+
            repeat_region
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9871
                     /organism="Thermotoga maritima MSB8"
                     /mol_type="genomic DNA"
                     /strain="MSB8"
                     /isolation_source="anaerobic marine mud"
                     /culture_collection="DSM:3109"
                     /type_material="type strain of Thermotoga maritima"
                     /db_xref="taxon:243274"
     gene            1..1950
                     /locus_tag="THEMA_RS08275"
                     /old_locus_tag="THEMA_08355"
     CDS             1..1950
                     /locus_tag="THEMA_RS08275"
                     /old_locus_tag="THEMA_08355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_229000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH42"
                     /protein_id="WP_004080133.1"
                     /translation="MLGVCYYPEHWGTEKVEEDFRRMKELGIEYVRIGEFAWSRIESER
                     GKFNWDWLDKTLELAEKMGLKIVLGTPTATPPKWLIDEHPEILPVDKDGRVKNFGSRRH
                     YCFSSPVYREEVKRIVTIIVKRYGKHPAVAGWQTDNEYGCHDTVRCYCPRCKKAFQKWL
                     ERKYEGDIKKLNEAWGTVFWSQEYRSFDEIELPNLTPADPNPSHLLDYYRLASDQVVEF
                     NKLQVEIIREYSPGRFITHNFMSGFTDFDHYKLSKDLDFATWDNYPLGHTLVFLRMKGE
                     TKNPFDRVGHPDIISFSHDLYRGVGRGRFWVMEQQAGPVNWAPYNLWPAKGAVRLWTWQ
                     AFAHGAEVVSYFRWRQAPFAQEQMHSGLLAPDSAPYPGYHEVKQVFEELKNIDINEPVE
                     SEVALVFDYETAWVFSIQPHGEGVNYIDLVFRFYSALRRLGLNVDIVPPGSSLDGYKMI
                     VVPSLAIVKEEVLDTFKKYDGLLVLGPRSGSKTETFQIPPEMPPGLLKEIIPVEVRQVE
                     SLGDNVETLVWNGKEYPVSIWREDVDPTITEVIARFKDGFGAIFRKENVFYLAFWPNGD
                     FLVDFFEALSKESGIETKRMPEGVRIQRRGEYVFSFNFTSEEVDLEIPTKVQIVLGDQK
                     IPPYGLLIWKENER"
     gene            1965..2945
                     /locus_tag="THEMA_RS08280"
                     /old_locus_tag="THEMA_08360"
     CDS             1965..2945
                     /locus_tag="THEMA_RS08280"
                     /old_locus_tag="THEMA_08360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_228999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q9WXS9|3.A.1.5.13"
                     /protein_id="WP_004080134.1"
                     /translation="METLISGKNLKAYYVLDLWGSKKVVKAVDNVSLDILPNEIYGIAG
                     ESGCGKSTLLKALLALLDPPLRLMDGELLYNIEGRPTNVTLLKSETIRKLRWSFISYIP
                     QGSMHVLNPVKRVRDTFIEILSSHVKKQTKEFLDLAVQHLKDLGLPERVLNMFPHQLSG
                     GMRQRVTIALATVLKPRVIFADEPTTALDVVAQRAVMQLIRKIQNDLKNTVVLVTHDMG
                     VHAQITTRMAIMYAGKIVEEGPTLEIFKNPLHPYTRYLIQSLPAIGDKKLRSGIPGSPP
                     SLVAPPPGCRFHPRCPHASQRCREEEPLLKEIKPGHKVACFLMEG"
     gene            2942..6205
                     /locus_tag="THEMA_RS08285"
                     /old_locus_tag="THEMA_08365"
     CDS             2942..6205
                     /locus_tag="THEMA_RS08285"
                     /old_locus_tag="THEMA_08365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_228998.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH2"
                     /protein_id="WP_010865279.1"
                     /translation="MKNMPYEWENPQLVSEGTEKSHASFIPYLDPFSGEWEYPEEFISL
                     NGNWRFLFAKNPFEVPEDFFSEKFDDSNWDEIEVPSNWEMKGYGKPIYTNVVYPFEPNP
                     PFVPKDDNPTGVYRRWIEIPEDWFKKEIFLHFEGVRSFFYLWVNGKKIGFSKDSCTPAE
                     FRLTDVLRPGKNLITVEVLKWSDGSYLEDQDMWWFAGIYRDVYLYALPKFHIRDVFVRT
                     DLDENYRNGKIFLDVEMRNLGEEEEKDLEVTLITPDGDEKTLVKETVKPEDRVLSFAFD
                     VKDPKKWSAETPHLYVLKLKLGEDEKKVNFGFRKIEIKDGTLLFNGKPLYIKGVNRHEF
                     DPDRGHAVTVERMIQDIKLMKQHNINTVRTSHYPNQTKWYDLCDYFGLYVIDEANIESH
                     GIDWDPEVTLANRWEWEKAHFDRIKRMVERDKNHPSIIFWSLGNEAGDGVNFEKAALWI
                     KKRDNTRLIHYEGTTRRGESYYVDVFSLMYPKMDILLEYASKKREKPFIMCEYAHAMGN
                     SVGNLKDYWDVIEKYPYLHGGCIWDWVDQGIRKKDENGREFWAYGGDFGDTPNDGNFCI
                     NGVVLPDRTPEPELYEVKKVYQNVKIRQVSKDTYEVENRYLFTNLEMFDGAWKIRKDGE
                     VIEEKTFKIFAEPGEKRLLKIPLPEMDDSEYFLEISFSLSEDTPWAEKGHVVAWEQFLL
                     KAPAFEKKSISDGVSLREDGKHLTVEAKDTVYVFSKLTGLLEQILHRRKKILKSPVVPN
                     FWRVPTDNDIGNRMPQRLAIWKRASKERKLFKMHWKKEENRVSVHSVFQLPGNSWVYTT
                     YTVFGNGDVLVDLSLIPAEDVPEIPRIGFQFTVPEEFGTVEWYGRGPHETYWDRKESGL
                     FARYRKAVGEMMHRYVRPQETGNRSDVRWFALSDGETKLFVSGMPQIDFSVWPFSMEDL
                     ERVQHISELPERDFVTVNVDFRQMGLGGDDSWGAMPHLEYRLLPKPYRFSFRMRISEEI
                     PSWRVLAAIPETLHVEMSSEDVIREGDTLRVKFSLLNDTPLSKEKQVVLFVDGNEYSVR
                     RVVIPPFKKEELVFKVEGLKKGEHLIHTNLNTRKTIYVR"
     gene            6211..7869
                     /locus_tag="THEMA_RS08290"
                     /old_locus_tag="THEMA_08370"
     CDS             6211..7869
                     /locus_tag="THEMA_RS08290"
                     /old_locus_tag="THEMA_08370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_228997.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="WP_004080136.1"
                     /translation="MEIFGKTFREGRFVLKEKNFTVEFAVEKIHLGWKISGRVKGSPGR
                     LEVLRTKAPEKVLVNNWQSWGPCRVVDAFSFKPPEIDPNWRYTASVVPDVLERNLQSDY
                     FVAEEGKVYGFLSSKIAHPFFAVEDGELVAYLEYFDVEFDDFVPLEPLVVLEDPNTPLL
                     LEKYAELVGMENNARVPKHTPTGWCSWYHYFLDLTWEETLKNLKLAKNFPFEVFQIDDA
                     YEKDIGDWLVTRGDFPSVEEMAKVIAENGFIPGIWTAPFSVSETSDVFNEHPDWVVKEN
                     GEPKMAYRNWNKKIYALDLSKDEVLNWLFDLFSSLRKMGYRYFKIDFLFAGAVPGERKK
                     NITPIQAFRKGIETIRKAVGEDSFILGCGSPLLPAVGCVDGMRIGPDTAPFWGEHIEDN
                     GAPAARWALRNAITRYFMHDRFWLNDPDCLILREEKTDLTQKEKELYSYTCGVLDNMII
                     ESDDLSLVRDHGKKVLKETLELLGGRPRVQNIMSEDLRYEIVSSGTLSGNVKIVVDLNS
                     REYHLEKEGKSSLKKRVVKREDGRNFYFYEEGERE"
     gene            7866..8822
                     /gene="galT"
                     /locus_tag="THEMA_RS08295"
                     /old_locus_tag="THEMA_08375"
     CDS             7866..8822
                     /gene="galT"
                     /locus_tag="THEMA_RS08295"
                     /old_locus_tag="THEMA_08375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_228996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="WP_004080138.1"
                     /translation="MMELRYNPLTDEWVIVSAATQKRPVQPSKTECPICVGGLELPEEY
                     DLVTFENRYPSLKKDPPPVNWKEKGPFRKEESRGVCEVVVYTSDHNTALPGMPLKQIEK
                     LVEMWVDRTRDLSQHDFVKYIFIFENRGKEVGASLPHPHGQIYAFPFLPKRIEVKIGAM
                     RKWYEEKRKCPICEVLESEGEERKVYETEHFLALVPFYARFPYEVHIYPKRHVSTLLEF
                     SKEEKKEFAKVLKVVTAKYDKLFDQEFPYMMMFFQAPFNEEDVSHFFHFHVEFNPPKRD
                     RDKLKWMASVETGTWAFINPVVPEEAARQLRETEVEI"
     gene            8819..9871
                     /locus_tag="THEMA_RS08300"
                     /old_locus_tag="THEMA_08380"
     CDS             8819..9871
                     /locus_tag="THEMA_RS08300"
                     /old_locus_tag="THEMA_08380"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_228995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="WP_004080140.1"
                     /translation="MKVKAPGRINIIGEHTDYNDGYVLPFAVNRYVFLSIEGSERFIFH
                     SENVNETVEMEKIEKLNKWTDYISGVIASFEKRGYRVSPVKISVSSNLPIGAGLSSSAA
                     LEVATAYAISEYFGFNVPKLELVKIAREAEVEFVGVRCGIMDQFTAVFGKKDHAIFLDT
                     MTLEYEYVPLKLEGYEINLVDSNVKHELSSSEYNRRRQECEEVLKTLEKKSFREVTKED
                     LERLSGTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEET
                     DFIVDYLRGKEGILGARMVGGGFGGGVIVLSKKGAFGKIKEELVESYRKRFGIDLIFHE
                     IESSDGVQKI"
ORIGIN
        1 atgctcggcg tctgttacta tccagaacac tggggaacag agaaagttga agaagacttc
       61 agaaggatga aagaactcgg gatagagtac gtgaggattg gagagttcgc ctggagcagg
      121 atagagtcgg agcgtggaaa gttcaactgg gactggctcg acaaaacact tgagctggca
      181 gagaagatgg ggctcaagat cgtactggga actcccacag ccacacctcc gaagtggctc
      241 atcgatgaac acccggagat ccttcccgtt gataaagatg gcagggtgaa aaattttggt
      301 tccagaagac attattgctt ctccagccct gtttatagag aggaagtgaa aagaatcgtc
      361 accataatag tgaaaagata cggaaaacac ccggcagtcg caggctggca gacggacaac
      421 gagtacggct gtcacgatac ggtgaggtgc tactgtccga ggtgcaaaaa agccttccaa
      481 aaatggctgg aaagaaagta cgagggagac ataaagaaat tgaatgaagc gtggggaaca
      541 gtgttctgga gccaggagta tcgatccttc gacgaaatag agcttccgaa tctcacccct
      601 gccgacccga acccgtcgca tcttctcgac tactacaggt tagcctccga ccaagtggtg
      661 gaattcaaca agctccaggt ggagataata agggagtatt cgccgggaag attcatcaca
      721 cacaatttca tgtccggttt cacagatttt gatcattaca aactctcgaa agacctggat
      781 ttcgcaacct gggacaatta cccgctcgga cacaccctcg tttttctgag aatgaagggt
      841 gagacaaaaa atccgttcga cagagtggga cacccggaca tcatctcatt ctcgcacgat
      901 ctgtaccggg gagtgggcag aggaagattc tgggtgatgg aacagcaagc aggacctgtg
      961 aactgggctc cttacaatct ctggcccgcc aagggagcgg tgagactctg gacgtggcag
     1021 gcgttcgcac acggtgcgga ggtggtctcc tacttcagat ggagacaggc accttttgcg
     1081 caggagcaga tgcactctgg acttctggca ccggattcag caccttaccc tggataccac
     1141 gaggtaaagc aggttttcga ggagctcaaa aacatcgata tcaatgagcc cgtggaaagc
     1201 gaagtggcac ttgtcttcga ttatgaaacg gcgtgggtct tctccataca accgcacggc
     1261 gagggggtga actacatcga tcttgtcttc agattctaca gtgccctcag aagactcggt
     1321 ctgaacgtgg atatagtacc ccctggatct tcactggacg gatacaaaat gatcgttgtt
     1381 ccaagccttg ccatcgtgaa ggaggaggtt ctggacacgt tcaaaaaata cgacggtctt
     1441 ctcgtacttg gcccaagaag cggaagcaaa acagagacat tccagatacc accagaaatg
     1501 cccccaggtc ttctcaagga gatcataccc gttgaagtga gacaggttga aagccttgga
     1561 gataatgttg agacacttgt ttggaacggt aaggaatacc ctgtctcgat atggagagag
     1621 gatgtggacc ccaccatcac ggaagtgatc gcaagattca aagatggttt tggagccatc
     1681 tttcgaaagg aaaacgtctt ctaccttgct ttctggccga atggagactt tctcgtagat
     1741 ttctttgaag cactttcaaa agaatcagga attgaaacga aaaggatgcc agaaggagta
     1801 cgcattcaaa ggagaggtga atatgttttt tctttcaatt tcacctctga ggaggtagat
     1861 ttagaaatac caacgaaagt tcagatagtt ctaggagatc aaaagattcc tccctatgga
     1921 ctgctgatat ggaaggaaaa cgaacgctga gggggatcca gcagatggaa acgttgatat
     1981 cgggaaagaa tttgaaagct tattacgtgc ttgacctttg gggcagtaaa aaagtggtaa
     2041 aagctgttga taacgttagc ctcgacatac tacctaacga aatttacggc atagctggtg
     2101 aatcgggttg tggaaagtcc acgcttttga aggccttgct tgctcttctc gatccaccgc
     2161 tacgtctgat ggatggtgag ttgttgtata acatagaagg aaggcctacg aatgtaacat
     2221 tgttgaaaag cgaaacaata aggaaattga ggtggagttt tatttcttac attccacagg
     2281 gatcaatgca cgttctcaat cccgtaaagc gagtgagaga tacgttcata gaaattctga
     2341 gcagtcacgt taaaaagcag actaaggagt ttctcgacct cgcagttcag catctgaagg
     2401 atcttggcct tcctgagaga gttctgaaca tgttcccgca tcagctgtcg ggaggtatga
     2461 gacagagggt taccatagca ctcgccacgg tcctgaaacc gcgcgtcata ttcgctgatg
     2521 aaccgacgac ggcactcgat gtggtggctc agcgagctgt tatgcagctt ataagaaaga
     2581 ttcaaaatga tctgaaaaac accgttgttc tggtaactca tgatatgggt gtgcacgccc
     2641 agatcacaac gaggatggcg atcatgtacg caggaaagat cgtggaggag ggccccacgc
     2701 tggaaatctt caaaaatcct ctccatcctt acacacgtta tctgatacag tctcttccag
     2761 cgatcggtga taagaaactg agatcaggaa ttcccggttc gccaccctca ctggtagcgc
     2821 ccccaccggg gtgcagattc cacccgaggt gtccgcatgc cagccagaga tgcagggaag
     2881 aagaaccact tttaaaggag ataaaaccgg gtcataaagt ggcctgtttt ttaatggagg
     2941 ggtgaagaat atgccctacg aatgggaaaa cccacagctt gtgagtgaag gaacggagaa
     3001 gtcacacgct tccttcatac cctatctgga cccgttcagc ggggaatggg agtaccctga
     3061 ggaattcatc tctttgaacg ggaactggag gtttctcttc gcgaaaaatc ccttcgaggt
     3121 gccggaggat ttcttttcgg agaaattcga cgactcgaac tgggatgaga tagaagttcc
     3181 aagcaactgg gaaatgaaag gatatggaaa gcccatctac acgaacgtgg tttatccatt
     3241 tgaaccgaac cctccttttg ttccaaaaga cgacaatccg accggggtgt acagaaggtg
     3301 gatcgagata cctgaggatt ggtttaaaaa ggagatcttt ctgcattttg aaggtgttcg
     3361 atccttcttc tatttgtggg tgaacgggaa gaagatcggt ttcagcaaag acagctgcac
     3421 gcccgctgaa ttcagactca ccgatgttct aagaccaggg aagaatctga tcaccgttga
     3481 ggttctgaag tggagcgatg gaagctatct cgaagatcag gacatgtggt ggtttgcggg
     3541 gatatacagg gacgtttatc tgtacgcgct gccgaagttt cacatcaggg acgtgttcgt
     3601 gagaacggat ctggatgaaa attacagaaa cggaaagatc tttctggacg tagagatgag
     3661 aaatctcggt gaggaagaag aaaaagacct tgaagtaaca ctcatcacac cggatggaga
     3721 cgaaaaaaca ctcgtgaaag agacagtaaa gccggaggac agagtccttt cctttgcctt
     3781 tgacgtgaaa gatccgaaga agtggtccgc ggagacacct cacctgtacg ttctgaagct
     3841 gaaactggga gaggacgaaa agaaagtcaa cttcggattc aggaagatag agataaaaga
     3901 cggaacgctt cttttcaacg ggaaacctct ctacataaag ggagtgaaca gacacgagtt
     3961 cgatcccgac aggggtcatg cggtgacagt ggagagaatg attcaggaca taaagctcat
     4021 gaagcagcac aacataaaca cggttcgcac atcacactat ccgaaccaga cgaagtggta
     4081 cgatctgtgt gactactttg gactctacgt gatagacgag gcaaacatcg aatcccacgg
     4141 tatagactgg gatcctgaag tgacccttgc gaacagatgg gaatgggaga aggcacattt
     4201 cgacagaatc aaaaggatgg tcgagcgcga caagaatcat cccagtatca tcttctggtc
     4261 tctcgggaac gaagcgggag atggagtgaa tttcgaaaaa gccgctctct ggataaagaa
     4321 aagagacaac acgcgactta tccattacga gggaacaaca aggaggggag aatcgtacta
     4381 cgtcgatgtt ttctctctca tgtatccgaa gatggacatt cttcttgagt acgcttcaaa
     4441 gaagagggaa aagcccttca tcatgtgtga gtatgcccac gcgatgggaa acagtgtggg
     4501 aaatctgaag gactactggg acgtgataga aaagtatccg taccttcatg gaggttgcat
     4561 ctgggactgg gtggatcagg gaataagaaa gaaagacgag aacggaagag aattctgggc
     4621 gtacggtggt gacttcggtg acacaccgaa tgacggaaac ttctgtataa acggtgtggt
     4681 actgcccgat agaacacctg agccggaact ttacgaggtg aagaaggtct atcagaacgt
     4741 caaaataaga caggtatcga aagacactta tgaggtggaa aacaggtatc tattcacgaa
     4801 ccttgagatg ttcgatggcg cctggaaaat cagaaaagac ggagaagtca tcgaagaaaa
     4861 aaccttcaag atcttcgctg aacctggaga aaagcgtctc ttgaagatac cactcccaga
     4921 aatggacgat tctgagtatt tcctcgagat cagtttctcc ctttctgagg ataccccctg
     4981 ggcagaaaaa ggccacgttg tggcgtggga gcagttcctt ctgaaagcac cggcatttga
     5041 gaaaaaatcc atttcagatg gagtgtcact cagggaggat gggaaacatc tcaccgttga
     5101 agcaaaagac acggtgtacg tcttctcaaa actcacaggc cttctggagc agatccttca
     5161 cagaagaaaa aagatcctga aaagtcccgt tgttcccaac ttctggaggg ttccaaccga
     5221 caacgacatc ggaaacagaa tgccacagag gctcgccatc tggaagaggg catcgaaaga
     5281 gagaaaactc ttcaaaatgc actggaaaaa ggaagaaaat cgtgtttctg tccatagtgt
     5341 ttttcagctt ccgggaaaca gctgggtgta cacaacatac accgttttcg gaaatggaga
     5401 cgtcctagtg gacctttctc tgattcccgc tgaggatgta ccggagattc caaggattgg
     5461 ctttcagttc acggttcctg aagagttcgg caccgtggag tggtacggaa ggggaccgca
     5521 cgagacttac tgggacagaa aagaaagtgg tcttttcgca aggtacagaa aagctgtcgg
     5581 tgagatgatg cacaggtacg tcaggcccca ggaaacgggg aacagatcgg acgtgagatg
     5641 gttcgcgctt tccgatggtg aaacaaaact ctttgtgtcg ggcatgccgc agatagactt
     5701 cagcgtctgg cctttttcca tggaggatct cgagagggtt cagcacataa gtgaactccc
     5761 ggagagggac ttcgtcaccg tgaacgtgga cttcagacag atgggccttg gaggagacga
     5821 cagctggggt gcgatgcctc atctggagta caggcttcta ccaaagccgt atcgcttttc
     5881 tttcagaatg aggattagcg aagagattcc atcctggagg gttcttgcgg cgatccctga
     5941 aacgctccat gttgagatgt cctcagaaga cgtgatacgc gaaggagaca ccctgagagt
     6001 gaaattttcc cttctgaacg acactccact gagcaaggaa aaacaggtgg ttctctttgt
     6061 tgatggaaac gaatactcgg tgaggcgagt ggtgattcca cccttcaaga aggaagagct
     6121 ggtgttcaaa gtagaaggat tgaagaaggg tgaacatctg atacatacta atctgaacac
     6181 gagaaaaact atctacgtga ggtgatctgt gtggaaatat tcggaaagac cttcagagag
     6241 ggaagattcg ttctcaaaga gaaaaacttc acagttgagt tcgcggtgga gaagatacac
     6301 cttggctgga agatctccgg cagggtgaag ggaagtccgg gaaggcttga ggttcttcga
     6361 acgaaagcac cggaaaaggt acttgtgaac aactggcagt cctggggacc gtgcagggtg
     6421 gtcgatgcct tttctttcaa accacctgaa atagatccga actggagata caccgcttcg
     6481 gtggtgcccg atgtacttga aaggaacctc cagagcgact atttcgtggc tgaagaagga
     6541 aaagtgtacg gttttctgag ttcgaaaatc gcacatcctt tcttcgctgt ggaagatggg
     6601 gaacttgtgg catacctcga atatttcgat gtcgagttcg acgactttgt tcctcttgaa
     6661 cctctcgttg tactcgagga tcccaacaca ccccttcttc tggagaaata cgcggaactc
     6721 gtcggaatgg aaaacaacgc gagagttcca aaacacacac ccactggatg gtgcagctgg
     6781 taccattact tccttgatct cacctgggaa gagaccctca agaacctgaa gctcgcgaag
     6841 aatttcccgt tcgaggtctt ccagatagac gacgcctacg aaaaggacat aggtgactgg
     6901 ctcgtgacaa gaggagactt tccatcggtg gaagagatgg caaaagttat agcggaaaac
     6961 ggtttcatcc cgggcatatg gaccgccccg ttcagtgttt ctgaaacctc ggatgtattc
     7021 aacgaacatc cggactgggt agtgaaggaa aacggagagc cgaagatggc ttacagaaac
     7081 tggaacaaaa agatatacgc cctcgatctt tcgaaagatg aggttctgaa ctggcttttc
     7141 gatctcttct catctctgag aaagatgggc tacaggtact tcaagatcga ctttctcttc
     7201 gcgggtgccg ttccaggaga aagaaaaaag aacataacac caattcaggc gttcagaaaa
     7261 gggattgaga cgatcagaaa agcggtggga gaagattctt tcatcctcgg atgcggctct
     7321 ccccttcttc ccgcagtggg atgcgtcgac gggatgagga taggacctga cactgcgccg
     7381 ttctggggag aacatataga agacaacgga gctcccgctg caagatgggc gctgagaaac
     7441 gccataacga ggtacttcat gcacgacagg ttctggctga acgaccccga ctgtctgata
     7501 ctgagagagg agaaaacgga tctcacacag aaggaaaagg agctctactc gtacacgtgt
     7561 ggagtgctcg acaacatgat catagaaagc gatgatctct cgctcgtcag agatcatgga
     7621 aaaaaggttc tgaaagaaac gctcgaactc ctcggtggaa gaccacgggt tcaaaacatc
     7681 atgtcggagg atctgagata cgagatcgtc tcgtctggca ctctctcagg aaacgtcaag
     7741 atcgtggtcg atctgaacag cagagagtac cacctggaaa aagaaggaaa gtcctccctg
     7801 aaaaaaagag tcgtcaaaag agaagacgga agaaacttct acttctacga agagggtgag
     7861 agagaatgat ggaactcagg tacaatccgc tcacagatga atgggtgatc gtttctgcag
     7921 ccacacagaa aagaccggta caaccatcga agacggagtg tcctatctgt gttggaggcc
     7981 tcgaacttcc cgaggagtac gatcttgtca ccttcgagaa caggtatcct tctctgaaaa
     8041 aagatccacc tcctgtgaac tggaaagaga agggaccttt caggaaagaa gagtcccgcg
     8101 gtgtctgcga ggtggtcgtc tacacctcgg atcacaacac agcacttcct ggaatgcctt
     8161 tgaagcagat agaaaagctc gttgagatgt gggtggacag aacaagggac ctttctcagc
     8221 acgactttgt gaaatatatc ttcattttcg aaaaccgcgg aaaggaagtc ggtgcttccc
     8281 ttccacaccc gcacggtcag atatacgcgt tccccttcct tccaaagaga atagaagtga
     8341 agataggcgc gatgagaaaa tggtacgaag agaaaaggaa gtgccccatc tgcgaggtcc
     8401 tggagagcga aggagaggag agaaaagttt acgagacgga acatttcctc gctctcgttc
     8461 ctttctacgc acgctttccg tacgaagtgc acatctatcc gaagagacac gtgagtactc
     8521 ttctggagtt ttcgaaagaa gaaaagaaag agttcgccaa agttctcaag gtggtgactg
     8581 caaaatacga caaactcttc gatcaggagt ttccctacat gatgatgttc tttcaggcac
     8641 cgttcaacga agaggacgtg tctcacttct tccacttcca cgtggagttc aacccaccga
     8701 agcgagacag agataaactg aagtggatgg cgagtgtcga gacgggtaca tgggcgttca
     8761 taaaccccgt cgttcccgaa gaagcagcga gacaactcag agagacggag gtggaaatat
     8821 gaaagtgaag gcaccaggaa gaataaacat catcggggag cacaccgact acaacgatgg
     8881 ttacgttctg ccgtttgcgg tgaatagata cgtgtttctc tcgatagaag gttcagagag
     8941 attcatcttc cactcagaaa acgtaaacga aacggtggag atggaaaaga tagagaaact
     9001 caacaaatgg acggattaca tctctggagt catcgcttct tttgaaaaaa ggggctacag
     9061 ggtgtctcct gttaaaatct ccgtttcttc caatcttccc ataggagcgg gtctttccag
     9121 ttccgccgct ctcgaggtgg cgaccgctta cgcgatttca gaatatttcg gtttcaacgt
     9181 tccgaaactc gaactcgtaa agatcgctcg tgaagccgaa gtggagttcg tgggggtcag
     9241 gtgtggcatc atggaccagt tcacggccgt ttttggaaag aaagaccacg cgatctttct
     9301 ggacacgatg acgctcgagt acgagtacgt tcctctgaaa ttggagggtt acgagatcaa
     9361 cctcgtcgac tcgaacgtta aacacgagct ctcctcttcg gagtacaaca gaagaagaca
     9421 ggagtgcgaa gaggtactga aaacgcttga gaaaaagagc tttcgagaag tgacaaaaga
     9481 agatctcgaa agactctcag gcaccctgag aaaacgtgcc cagcacgtgc tcgaagaaaa
     9541 cgaaagagtc ctgaaaagtg ttcaggcttt gaaagaagga gattttgaaa cccttggaaa
     9601 actgctcttt tcttctcacg agagtctcag agacctgtac gaagtttcct gcgaggaaac
     9661 ggatttcatc gtggattatt tgagaggaaa ggaaggtatc ctcggtgcga ggatggtcgg
     9721 tggcggattc ggagggggag tgatcgttct ttcaaagaag ggggcttttg ggaagataaa
     9781 agaagagctg gtggagtctt acaggaagcg tttcgggata gatctcatct tccacgagat
     9841 agagagttca gacggtgttc aaaaaatcta a
//
