LOCUS       STRMSM                 10995 bp    DNA     linear   BCT 16-FEB-1994
DEFINITION  Streptococcus mutans regulatory protein (msmR), a-galactosidase
            (aga), sugar binding protein (msmE), membrane proteins (msmF and
            msmG),sucrose phosphorylase (gftA), ATP-binding protein (msmK), and
            dextran glucosidase (dexB) genes, complete cds.
ACCESSION   M77351
VERSION     M77351.1
KEYWORDS    ATP-binding protein; a-galactosidase; aga gene; dexB gene; dextran
            glucosidase; gtfA gene; membrane protein; msmE gene; msmF gene; msmG
            gene; msmK gene; msmR gene; regulatory protein; sucrose
            phosphorylase; sugar-binding protein.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Ferretti,J.J., Huang,T.T. and Russell,R.R.
  TITLE     Sequence analysis of the glucosyltransferase A gene (gtfA) from
            Streptococcus mutans Ingbritt
  JOURNAL   Infect. Immun. 56 (6), 1585-1588 (1988)
   PUBMED   2967248
REFERENCE   2
  AUTHORS   Russell,R.R. and Ferretti,J.J.
  TITLE     Nucleotide sequence of the dextran glucosidase (dexB) gene of
            Streptococcus mutans
  JOURNAL   J. Gen. Microbiol. 136 (Pt 5), 803-810 (1990)
   PUBMED   2380687
REFERENCE   3
  AUTHORS   Aduse-Opoku,J., Tao,L., Ferretti,J.J. and Russell,R.R.
  TITLE     Biochemical and genetic analysis of Streptococcus mutans
            alpha-galactosidase
  JOURNAL   J. Gen. Microbiol. 137 (Pt 4), 757-764 (1991)
   PUBMED   1649890
REFERENCE   4  (bases 1 to 10995)
  AUTHORS   Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. and
            Ferretti,J.J.
  TITLE     A binding protein-dependent transport system in Streptococcus mutans
            responsible for multiple sugar metabolism
  JOURNAL   J. Biol. Chem. 267 (7), 4631-4637 (1992)
   PUBMED   1537846
FEATURES             Location/Qualifiers
     source          1..10995
                     /organism="Streptococcus mutans"
                     /mol_type="genomic DNA"
                     /strain="Ingbritt"
                     /db_xref="taxon:1309"
     gene            complement(291..1141)
                     /gene="msmR"
     CDS             complement(291..1127)
                     /gene="msmR"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_AraC,DBD-Pfam|HTH_AraC,DBD-Pfam|HTH_
                     AraC,DBD-SUPERFAMILY|0036286,DBD-SUPERFAMILY|0035607,DBD-SU
                     PERFAMILY|0035607"
                     /protein_id="AAA26932.1"
                     /translation="MNIVNIYNEFDINNFDLSVDHYGSEKCDRGYSFGPTIRDNYVIHF
                     ILEGKGKLTINQHTLDLAAGDIFLLPKDISTFYQADLQMPWSYIWIGFRVQKPKIFLSS
                     QAFLNLFYCHSGRSSKLFSQMMTIIQFANTPLTSVNELLMVGELYKLLAALIEEFPLSH
                     LEESNSSTKAYVNQVKKIIHSQYGSSLRVNDIAKKLNLSRSYLYKIFRKSTNLSIKEYI
                     LQVRMKRSQYLLENPKLSIAEISNSVGFSDSLAFSKAFKNYFGKSPSKFRKEIQNN"
     regulatory      complement(1136..1141)
                     /regulatory_class="ribosome_binding_site"
                     /gene="msmR"
     gene            1236..3398
                     /gene="aga"
     CDS             1236..3398
                     /gene="aga"
                     /EC_number="3.2.1.22"
                     /codon_start=1
                     /transl_table=11
                     /product="GH36"
                     /protein_id="AAA26933.1"
                     /translation="MGIVIKDNLFYIHTKDSSLIIEERDGDLLLKHLGKKIEAYHFSNT
                     VFEKDHAFSANPVADNRNYSYDTQRQIFGVHGFGDFRVPSLILQHDNNDLTRFKFKKAK
                     IIKGGIKARGLPNPHSSESAQSLALILEDDLAKSRIVSDYTAYDDNATISTFVKFENLS
                     DKPVILHRALSTMFDLPASHYDVITFQGAYAREKSLRRHQIEQGLFKIGSNRGASGHAQ
                     TPSLILTEHDSNEFYGEALALQLIYSGNFQAFVQKNQLNVVRLGIGINDDNFSWELQAN
                     QSFETPVALITYTDKGLTDLTQESHNFIKRHIIPKNFANKERPILINNWEATYFDFNRS
                     QLLGLADEARKLGIELFVLDDGWFGHRFDDNSSLGDWFVNEEKLGGSLDSFIKEIHDRG
                     LQFGLWFEPEMVSVDSKLYRAHPDWVIQADQREHTYSRNQLVLNLANLDVVAYIKTVLD
                     KLLTENTIDYVKWDYNRNITNIGNGRTYLETQMQSHAYILGLYDMFSYLTTKHDKVLFE
                     SCSGGGGRNDLGMMCYFPQVWSSDNTDAIARLPIQYGSSYLYPTISMGAHVSAVPNHQM
                     NRHTPLTTRAHVAMMGNLGYELDLAVLTKNEKKAVANQIKHYKKIRSVVQFGKLYRLIN
                     PEVGINEVAVQYTYDNQVLVTYVRIQSTIEMMETTVKLRGLDADAIYVLIETGQAFSGA
                     ELMYAGLTIDMPQGDYLSKQYYFIKK"
     gene            3411..4673
                     /gene="msmE"
     CDS             3411..4673
                     /gene="msmE"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00749|3.A.1.1.28"
                     /protein_id="AAA26934.1"
                     /translation="MKWYKKIGLLGIVGLTSVLLAACNKSNGSQSKDDKVTIEYFNQKK
                     EMDATLKKIIKDFERENPKIHVKMTSVPDAGTVLKTRVLSGDVPDVINIYPQNMDFQEW
                     SKAGYFYNMTGKAYLNHLKNHYANEYKVNQKVYSVPLTANVSGIYYNKTKFKELGLKVP
                     ETWDEFVKLVEEIKAKKETPFALAGTEGWTLNGYHQLSLISVTGSANAANKYLRFSQPN
                     SIKTSDKILKEDMVRLNLLADDGNQQKNWKGASYNDALVAFANEKALMTPNGSWPCQLL
                     NNKIPNFEIGTFAFPGKKTGNGITVGAGDLALSISAKTKHLKEAEKFVKYMTTARAMQK
                     YYDVDGSPVAVKGVREDKNSPLQPLTKLAFTHKHYVWLGQHWNSEDDLFTATTNYLMTK
                     NAKGLADGLNAFFNPMKADVD"
     gene            4672..5558
                     /gene="msmF"
     regulatory      4672..4677
                     /regulatory_class="ribosome_binding_site"
                     /gene="msmF"
     CDS             4686..5558
                     /gene="msmF"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00750|3.A.1.1.28"
                     /protein_id="AAA26935.1"
                     /translation="MTIRKVLNKYWGWTFLIVPLILQVVFFYFPMFQGAFYSFINWTGL
                     TYNFDFVGINNYKILMTDGKFMKAIGFTLVSTLALIVGEIVLGIIIARALNAKIKGKTF
                     FRAWFFFPAVLSGLTVSLIFKQVFNYGLPAVGSALGIKFLETSMLGTANGAVIASIFVL
                     LWQGVAMPIILFLSGLQSIPSEIVEAAAIDGADSKQTFWSVELPYLLPSISMVFIMALK
                     AGLTAFDQIFALTGGGPNNSTTSLGLLVYNYAFKSNQYGYANAIALILFIIIGIVSVLQ
                     IKLSKKFEV"
     gene            5573..6406
                     /gene="msmG"
     CDS             5573..6406
                     /gene="msmG"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00751|3.A.1.1.28"
                     /protein_id="AAA26936.1"
                     /translation="MKKEEKINYFWKYVLLTVGGILILIPLMVTVFSSFKKTKDIMNHF
                     FAFPNPITLDNYKRLLADGVGGYFWNSTVITVLSVLVVMLFIPAAAYSIARNMSRRKAF
                     NIMYSLLILGIFVPFQVIMIPITVMMSKLGLANMWGLIILYLTYAIPQTLFLYVGYIKL
                     SVPDSLDEAAEIDGADKLTTYRKIIFPMLKPMHATTLIINALWFWNDFMLPLLILNKDS
                     SMWTLPLFQYNYSGQYFNDYGPSFASYIVGIITITIVYLIFQKHIIAGMSNGAVK"
     gene            6602..8047
                     /gene="gftA"
     CDS             6602..8047
                     /gene="gftA"
                     /EC_number="2.4.1.7"
                     /codon_start=1
                     /transl_table=11
                     /product="GH13_18|GH13"
                     /protein_id="AAA26937.1"
                     /translation="MPITNKTMLITYADSLGKNLKELNENIENYFGDAVGGVHLLPFFP
                     STGDRGFAPIDYHEVDSAFGDWDDVKRLGEKYYLMFDFMINHISRQSKYYKDYQEKHEA
                     SAYKDLFLNWDKFWPKNRPTQEDVDLIYKRKDRAPKQEIQFADGSVEHLWNTFGEEQID
                     LDVTKEVTMDFIRSTIENLAANGCDLIRLDAFAYAVKKLDTNDFFVEPEIWTLLDKVRN
                     IAAVSGAEILPEIHEHYTIQFKIADHDYYVYDFALPMVTLYSLYSGKVDRLAKWLKMSP
                     MKQFTTLDTHDGIGVVDVKDILTDEEITYTSNELYKVGANVNRKYSTAEYNNLDIYQIN
                     STYYSALGDDDQKYFLARLIQAFAPGIPQVYYVGFLAGKNDLELLESTKEGRNINRHYY
                     SSEEIAKEVKRPVVKALLNLFTYRNQSAAFDLDGRIEVETPNEATIVIERQNKDGSHIA
                     TAEINLQDMTYRVTENDQTISFE"
     gene            8050..9195
                     /gene="msmK"
     regulatory      8050..8055
                     /regulatory_class="ribosome_binding_site"
                     /gene="msmK"
     CDS             8062..9195
                     /gene="msmK"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q00752|3.A.1.1.28"
                     /protein_id="AAA26938.1"
                     /translation="MVELNLNHIYKKYPNSSHYSVEDFDLDIKNKEFIVFVGPSGCGKS
                     TTLRMVAGLEDITKGELKIDGEVVNDKAPKDRDIAMVFQNYALYPHMSVYDNMAFGLKL
                     RHYSKEAIDKRVKEAAQILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPL
                     SNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSSTKNEDGSGTIG
                     RVEQVGTPQELYNRPANKFVAGFIGSPAMNFFDVTIKDGHLVSKDGLTIAVTEGQLKML
                     ESKGFKNKNLIFGIRPEDISSSLLVQETYPDATVDAEVVVSELLGSETMLYLKLGQTEF
                     AARVDARDFHEPGEKVSLTFNVAKGHFFDAETEAAIR"
     gene            9283..10896
                     /gene="dexB"
     regulatory      9283..9288
                     /regulatory_class="ribosome_binding_site"
                     /gene="dexB"
     CDS             9286..10896
                     /gene="dexB"
                     /EC_number="3.2.1.70"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q05839|8.A.9.1.1"
                     /protein_id="AAA26939.1"
                     /translation="MQKHWWHKATVYQIYPKSFMDTNGDGIGDLKGITSKLDYLQKLGV
                     MAIWLSPVYDSPMDDNGYDIANYEAIADIFGNMADMDNLLTQAKMRDIKIIMDLVVNHT
                     SDEHTWFIEAREHPDSSERDYYIWCDQPNDLESIFGGSAWQYDDKSDQYYLHFFSKKQP
                     DLNWENANLRQKIYDMMNFWIDKGIGGFRMDVIDMIGKIPAQHIVSNGPKLHAYLKEMN
                     AASFGQHDLLTVGETWGATPEIAKQYSNPVNHELSMIFQFEHIGLQHKPEAPKWDYVKE
                     LNVPALKTIFNKWQTELELGQGWNSLFWNNHDLPRVLSIWGNTGKYREKSAKALAILLH
                     LMRGTPYIYQGEEIGMTNYPFKDLNELDDIESLNYAKEAFTNGKSMETIMDSIRMIGRD
                     NARTPMQWDASQNAGFSTADKTWLPVNPNYKDINVQAALKNSNSIFYTYQQLIQLRKEN
                     DWLVDADFELLPTADKVFAYLRKVREERYLIVVNVSDQEEVLEIDVDKQETLISNTNES
                     AALANHKLQPWDAFCIKIN"
ORIGIN
        1 gaattctctt tttttgctga ttagaggttg cgtcataatg aaagaaaagg agggggaaaa
       61 atgattttta tggctatcat gtgtgtttgt ctcaacttct gtttggtggg gcagtttgtt
      121 tatcaaacgt gtgtcngcct agtactaaaa agtaagcgga atggctctat tagtctagga
      181 aatcacttta caaaattaga aatagtgcta caataaattt gtatcgcaaa cgtttgcaaa
      241 gctgttcctt tctaataaaa aagaccaata gttgtgcaaa actcatttgc ttaattattt
      301 tggatttctt ttctaaattt actggggctt tttccaaaat aatttttaaa ggctttacta
      361 aatgcaagtg aatcgctaaa accaacagaa ttggatattt cagcaatact taatttggga
      421 ttttcaagca aatactgact tcttttcatt ctgacttgaa gtatgtactc ttttatggaa
      481 agatttgtac tttttctaaa aattttatag agataacttc gactaagatt cagcttttta
      541 gcaatatcat taactcgaag ggaactgcca tactgcgaat gtattatttt tttcacttgg
      601 ttaacataag cttttgttga gctattgctc tcttctaagt gagatagagg aaattcttca
      661 atgagggcag ctaaaagctt ataaagttca cctaccatta gtaattcatt gacagaggtt
      721 aagggggtgt tggcaaattg aataatggtc atcatttgtg agaagagctt ggagctgcgg
      781 cctgaatgac aataaaaaag gtttaaaaag gcttgactgc ttaagaatat tttcggcttt
      841 tgaaccctaa agccaatcca gatatagctc caaggcattt ggagatctgc ttgataaaag
      901 gttgagatat ctttggggag aaggaagata tcacctgctg ctaagtcaag ggtgtgttga
      961 tttatggtaa gttttccttt accttcaagg atgaaatgaa tgacataatt gtctcgaata
     1021 gttggaccaa aggaatagcc tctatcacat ttttctgaac cgtagtgatc aacgcttaaa
     1081 tcgaaattat taatatcaaa ttcattatag atatttacaa tattcatttt ctttaccttt
     1141 ctttaggaaa cattttacca tattttagca acaaacacct attttttaaa acggttacaa
     1201 aatgtataat aaggcataat atgaagggag aacaaatggg cattgttatt aaagataacc
     1261 ttttttatat acacaccaaa gactcatcat tgattattga agaaagagat ggtgatttgc
     1321 ttttaaaaca tctaggtaaa aaaattgaag cctatcattt ttccaatact gtttttgaaa
     1381 aggatcatgc tttttcagct aatccagtgg cggacaatag aaattatagt tatgatacac
     1441 aaagacaaat atttggtgtt catggttttg gtgattttag agtgccttca ctaatccttc
     1501 aacatgataa taatgattta acacggttta aatttaagaa ggctaaaatt attaaggggg
     1561 ggatcaaggc aagaggtttg cctaatccac atagcagtga gagtgctcaa agcttggctc
     1621 ttatcttaga agatgatttg gcaaaatcgc gcatagtctc tgattatacg gcttatgatg
     1681 ataatgccac catttcaacc tttgtcaaat ttgaaaattt atctgataag cctgttattc
     1741 ttcatcgtgc tttatcaaca atgtttgatt tacctgccag ccattatgat gtgataactt
     1801 ttcaaggagc ttatgctcgc gagaagagcc ttcggcgcca ccagattgaa cagggtctgt
     1861 ttaaaatagg ctctaatcga ggagcttcag gacatgctca aaccccttcc ttaattttaa
     1921 cagagcatga tagcaatgag ttttatgggg aggctttggc tttacaatta atctatagcg
     1981 gaaattttca agcttttgtt caaaaaaatc aattaaacgt ggttcgctta ggcatcggaa
     2041 taaatgatga taatttttca tgggaactgc aggctaatca gagttttgag acacctgtag
     2101 ctttgataac ctacactgat aagggattaa cggatctgac acaagaaagt cataatttta
     2161 ttaaacgtca tattattcct aagaattttg ctaataagga acgtcctatc cttatcaata
     2221 attgggaggc aacatatttt gattttaatc ggagtcaatt gctggggctg gcagatgaag
     2281 ccagaaaact tggcattgaa ctctttgtgc ttgacgatgg ttggtttggt catcgttttg
     2341 atgacaatag ctcacttggt gattggtttg tcaatgaaga aaaacttggt ggttcccttg
     2401 atagctttat caaggaaatt catgatagag gattacagtt tggcctttgg tttgaaccag
     2461 aaatggtatc agttgacagc aaactttata gagctcatcc tgattgggtc attcaggcag
     2521 atcagcgaga gcatacttat tctcgcaatc aattggtctt gaatctagct aatctcgatg
     2581 tagttgctta tataaaaact gttcttgata agctgctgac agaaaatacg attgattatg
     2641 ttaaatggga ctacaatcgc aatataacca atattggcaa tggcagaact tacttggaaa
     2701 cgcaaatgca gtcgcatgct tatatactgg ggttgtatga tatgttttct tacttaacaa
     2761 caaaacacga taaggtcttg tttgaatcct gttcaggagg tggcggtcgc aacgatttgg
     2821 ggatgatgtg ttattttcct caagtgtggt caagtgataa tacagatgct attgcaagac
     2881 tgcctataca gtatggttcc tcttatcttt acccaactat ttctatggga gcccatgttt
     2941 cagcggttcc taaccatcaa atgaaccgtc atacccctct tacaacacga gctcatgttg
     3001 ctatgatggg aaatttaggt tatgaattgg acttagcagt cttaaccaaa aatgaaaaaa
     3061 aggctgttgc caatcagatt aaacattata aaaagataag gtctgttgta caatttggca
     3121 agctttaccg tctaattaat cccgaagttg gaattaatga ggtagcagtg caatatacct
     3181 atgacaatca ggtactggtt acctatgtcc gtattcaatc aaccatagag atgatggaga
     3241 caactgtaaa gttgagagga ctagatgcag atgccattta tgttcttata gaaactggac
     3301 aagccttttc aggtgcggag ttaatgtatg cgggattgac cattgatatg ccgcaaggtg
     3361 attatttgag taaacaatac tattttatta aaaagtagaa ggagacactt atgaaatggt
     3421 ataaaaaaat tggattacta ggtattgtcg gtctgacgag cgtcttacta gctgcatgca
     3481 acaaaagtaa cggttcgcag tcaaaggatg ataaagtaac aattgagtat tttaaccaaa
     3541 aaaaagaaat ggacgctacc ttgaaaaaga taattaagga ctttgaaagg gaaaatccta
     3601 aaattcatgt caagatgact agtgttccag atgctggtac agtcctcaaa acgcgtgtct
     3661 tatcaggaga tgtgcccgat gttatcaata tttatcctca aaatatggac tttcaagaat
     3721 ggtccaaagc aggttatttt tataatatga cgggtaaagc ctatctgaac catttaaaga
     3781 atcattatgc taacgaatat aaagttaatc aaaaggttta cagcgtcccg ttaacagcta
     3841 atgtttcagg aatttattat aacaagacca aatttaaaga attaggtttg aaggttcctg
     3901 aaacttggga tgagtttgtt aaattggttg aagaaatcaa agcaaaaaag gaaacaccat
     3961 ttgctttagc gggaacagaa ggttggacct tgaatggtta tcatcagtta tccttgattt
     4021 cagtcactgg cagtgctaat gccgctaata aataccttcg cttttcccaa ccaaattcga
     4081 ttaaaaccag tgataaaatt ttaaaagaag atatggttcg gctcaatctt ttagcagatg
     4141 atggcaatca gcagaaaaat tggaagggag cttcttataa tgatgctctt gtggcatttg
     4201 ctaatgaaaa agctcttatg acacctaatg gttcgtggcc ttgccagcta ttaaacaaca
     4261 agatcccaaa ttttgaaatt ggaacctttg cttttccggg caaaaaaact ggaaatggca
     4321 taacagttgg agccggagat ttagctctat caatttcagc taaaacaaaa catcttaaag
     4381 aagctgaaaa atttgttaaa tacatgacga ctgctagggc gatgcagaaa tattatgatg
     4441 ttgatggttc accagtagca gtaaaaggag tcagagaaga taagaattca cctttgcaac
     4501 ctttaactaa attagctttt actcataaac actatgtgtg gttaggtcag cattggaata
     4561 gtgaagatga tttgtttaca gccacaacca attatctaat gacaaaaaat gctaaaggtt
     4621 tagctgatgg gcttaacgct ttctttaatc caatgaaagc agacgttgat taggagggat
     4681 aagggatgac tattagaaaa gttttaaata aatactgggg ttggacattt ttaatcgtac
     4741 cgctcatttt acaagttgta ttcttttatt ttcctatgtt tcagggtgct ttttatagct
     4801 ttatcaattg gacaggtctg acctataatt ttgattttgt tggtattaat aattataaga
     4861 ttttgatgac tgatgggaaa tttatgaagg ctattggttt tactttggtt tcgactctgg
     4921 ccttgattgt cggtgaaatt gtccttggta ttatcattgc acgtgcgctt aatgctaaga
     4981 tcaaaggaaa aacttttttc agagcctggt tcttctttcc agctgtttta tctggtttga
     5041 cagtttcttt gatttttaaa caggttttca attatggttt gccagcagtt ggcagtgctt
     5101 tgggaattaa atttttagaa acaagtatgt tgggaacagc gaacggggcg gttattgctt
     5161 caatctttgt tcttttgtgg caaggtgttg ctatgcctat tattcttttc ctttcaggat
     5221 tacagagtat tccatcagag attgtcgaag cagcagctat tgatggtgct gacagtaaac
     5281 agaccttttg gtcagtcgag ttgccctact tactgccaag tatttccatg gttttcatca
     5341 tggctttaaa agctggtctt acggcctttg atcaaatctt tgccttaaca ggtggcggtc
     5401 caaataattc aacaacatca ttaggccttt tggtttataa ctatgccttt aagagtaatc
     5461 agtatggtta tgctaatgct attgctttga ttttattcat tatcattgga attgtttctg
     5521 tgctgcaaat taaactctct aagaagtttg aagtttagag gagactgatg ctatgaaaaa
     5581 agaagaaaaa ataaattatt tttggaaata tgtacttttg actgttggtg gcatcctgat
     5641 tttgatccca ctgatggtta ctgtctttag ctcttttaag aaaactaagg atattatgaa
     5701 tcattttttt gcctttccaa atcctatcac cttggataat tacaaacgtt tgttagctga
     5761 tggtgttgga ggctattttt ggaattcaac ggtgattact gttttatccg ttttggtggt
     5821 catgctcttt atccctgcag cggcttattc cattgcgcgt aacatgtcta gaagaaaagc
     5881 tttcaatatc atgtatagcc tgttgattct gggaattttc gttcctttcc aggttatcat
     5941 gattcctatt acggttatga tgagtaaatt aggcttggct aatatgtggg gattaattat
     6001 tctgtattta acttatgcta ttccacagac actcttcctt tacgtgggtt atatcaaact
     6061 aagtgtacct gatagtttag atgaagcagc tgaaattgat ggtgcggata aattgacaac
     6121 ttatcgtaaa atcattttcc ctatgttaaa accaatgcac gcaacaactc tgattattaa
     6181 tgcactttgg ttctggaacg attttatgtt gccattgctg attcttaata aggattcaag
     6241 tatgtggacg cttcctcttt tccaatacaa ttatagcgga caatatttca atgattacgg
     6301 tcctagtttt gcttcttaca ttgttggtat tattaccatt acaattgttt atcttatttt
     6361 ccaaaaacac attattgctg gtatgagcaa tggagctgtg aagtgagagc tatagataat
     6421 gaccgcttaa gcagctcttc atcaactaac gccagccgct atggcggtct gcctaagctt
     6481 tccactagct cgccacccgc aataagaacg attacttctg gctcgcgtcg taggagctaa
     6541 agatgtggct gttattttta ggttgaactg gtataaacca aaattaatta gaggagataa
     6601 aatgccaatt acaaataaaa caatgttgat tacttacgca gacagtttgg gtaaaaattt
     6661 gaaagaattg aatgaaaata ttgagaatta ttttggagat gctgttggcg gtgtccattt
     6721 gctgccattc tttccttcca caggtgatcg tggctttgca ccgattgatt accatgaagt
     6781 tgactctgct tttggcgatt gggatgatgt caaacgcttg ggtgaaaaat attacctcat
     6841 gtttgatttc atgattaatc atatttcgcg tcagtctaaa tattataaag attaccaaga
     6901 aaagcatgaa gcaagtgctt ataaagatct atttttaaat tgggataaat tttggcctaa
     6961 aaatcgcccg acacaagaag atgtggacct gatttataag cgtaaggatc gagcacctaa
     7021 acaggaaatc caatttgcag atggcagtgt tgaacatctc tggaacactt ttggggagga
     7081 acagattgat cttgacgtga ctaaagaagt gactatggat tttattcgct ctaccattga
     7141 aaatttagca gccaacggct gtgatctcat tcgtttggat gcctttgctt atgctgttaa
     7201 aaagctagat acgaatgatt tctttgttga acctgaaatc tggactctgc tagataaagt
     7261 tcgtaatata gctgctgtat cgggtgcgga aatcttgccg gaaattcatg aacactatac
     7321 tattcaattt aaaattgcag accatgatta ctatgtttat gattttgccc tgcctatggt
     7381 gacgctctac agcctatatt cgggcaaggt tgaccgtctt gccaaatggc tgaaaatgag
     7441 tccgatgaaa cagttcacca cccttgatac acatgacggt attggtgtgg ttgatgttaa
     7501 ggatatcttg actgacgaag aaattaccta tacttctaat gagctttata aggtcggtgc
     7561 caatgtcaat cgtaagtatt caactgccga atataataac ttggatatct atcaaattaa
     7621 ttcaacttac tattcagcac ttggtgatga tgatcaaaaa tactttttgg cccgcttgat
     7681 acaagctttt gctccaggta ttccacaggt ttattacgtt ggctttttag ctggcaagaa
     7741 tgatcttgaa ttactggaaa gcactaaaga aggccgcaat atcaaccgtc attattatag
     7801 tagtgaagaa attgctaagg aagtgaagcg accagttgtc aaggcacttt taaatctctt
     7861 tacttaccgc aatcagtcag cagcttttga tttggatggc cgtattgaag tggaaacgcc
     7921 aaatgaagcg accattgtca tagaacgtca aaataaagat ggcagtcata tcgcaacagc
     7981 agagattaat ctccaagata tgacatacag agtaacagaa aatgatcaaa caataagctt
     8041 tgaataatta ggagagagac tatggttgaa ctaaatttaa atcacattta taaaaaatac
     8101 cctaacagca gtcattactc tgttgaagat tttgacttgg atatcaagaa caaagaattc
     8161 atcgtttttg ttggtccttc aggctgcgga aaatcaacaa cccttcggat ggttgctggt
     8221 ttggaggata ttaccaaggg cgaacttaaa attgacggtg aagtggtcaa tgataaggcc
     8281 cccaaagatc gcgatattgc tatggttttc caaaactatg cgctttatcc tcatatgagc
     8341 gtttatgata atatggcttt tggacttaaa ctacgtcact attccaaaga agctattgat
     8401 aagcgtgtca aggaagctgc acaaattctt ggtctgaccg aatttttaga acgtaaacca
     8461 gctgatttat ccggaggtca acgtcagcgt gtggctatgg gtcgggcaat tgttcgtgat
     8521 gccaaggtct ttttgatgga tgagcccctg tccaatttag atgccaagtt gcgggtatct
     8581 atgcgggcag agattgcgaa aattcatcgt cgtatcggtg caacgaccat ttatgttacc
     8641 catgaccaaa cggaagccat gaccttagct gaccgtattg ttattatgag ttcaacaaaa
     8701 aatgaggatg gttcaggtac aattggccgc gtggaacagg taggaacgcc tcaggaactt
     8761 tataaccggc ctgctaataa attcgttgct ggttttatcg gcagtccagc catgaacttc
     8821 tttgatgtta ctatcaaaga tgggcatctg gtcagtaagg atggtttaac gattgctgtt
     8881 acagaagggc agcttaaaat gcttgagtct aaaggtttta agaataagaa cttaattttt
     8941 ggtattcgtc cggaggatat ttccagcagt cttttagttc aggaaactta tccagatgct
     9001 acagttgatg cagaagtggt tgtctcagaa ttgcttggca gtgaaaccat gctttatctt
     9061 aaacttgggc aaacagaatt tgcagcacgt gtcgatgcta gagatttcca tgaaccgggt
     9121 gaaaaggtct ctctcacctt taatgttgcc aagggtcact tctttgacgc agaaacggaa
     9181 gcagccattc gataaaaaac ggcttaaatt gttttagatt ttctcagtct ctttattaga
     9241 actaaagaaa ctaacatgtc ataataaatt aaaggtggtg ataagatgca aaaacattgg
     9301 tggcacaagg caactgttta tcaaatttat ccaaaatctt ttatggatac aaatggtgat
     9361 ggaattggtg atctcaaagg tattacgagt aaattggatt atttgcaaaa gttaggggtt
     9421 atggctattt ggctatctcc agtttatgat agccccatgg atgacaatgg ctatgacatt
     9481 gcgaactatg aagcaattgc ggatattttt ggcaatatgg ctgatatgga taatttgctg
     9541 acgcaggcaa aaatgcgcga cataaaaatc attatggatc tagtggttaa tcatacctca
     9601 gatgaacata cttggtttat tgaagcacgt gagcatccag acagttctga acgcgattat
     9661 tatatttggt gtgaccagcc aaatgatttg gaatctattt tcggtggttc tgcttggcag
     9721 tatgatgata agtccgatca atattatttg cattttttta gtaagaagca gccagatcta
     9781 aactgggaaa acgcaaactt acgtcagaag atttatgata tgatgaattt ctggattgat
     9841 aaaggtattg gcggctttcg gatggacgtc attgatatga ttgggaaaat tcctgctcag
     9901 catattgtca gtaacggacc aaaattgcat gcttatctta aggagatgaa tgccgctagt
     9961 tttggtcaac atgatctgct gactgtgggg gaaacttggg gagcaacgcc tgagattgcg
    10021 aagcaatatt caaatccagt caatcacgaa ctctctatga tttttcaatt tgaacatatt
    10081 ggtcttcagc ataaaccaga agctcctaaa tgggattatg tgaaggaact taatgttcct
    10141 gctttaaaaa caatctttaa taaatggcag actgagttgg aattaggaca ggggtggaat
    10201 tcgttattct ggaataacca tgacctgcct cgtgttttat caatctgggg aaatacgggc
    10261 aaatatcgtg agaagtctgc taaagcactg gctattcttc ttcaccttat gcgtgggaca
    10321 ccttatattt atcaaggtga agagattggg atgaccaatt atccttttaa agatttaaat
    10381 gaacttgatg atattgaatc acttaattat gctaaggaag cttttacaaa tggtaagtct
    10441 atggaaacta tcatggacag tattcgtatg attggccgtg ataatgccag aacacctatg
    10501 caatgggatg cttctcaaaa tgccggattt tcaacagcgg ataaaacatg gctgccagtt
    10561 aatccaaact ataaagacat caatgttcaa gcagctctga aaaattccaa ttctatcttt
    10621 tacacctatc aacaactcat tcagcttcga aaagaaaatg attggctagt agatgccgat
    10681 tttgaattgc tccctacagc ggacaaagta tttgcctatt tacgaaaggt aagagaagaa
    10741 aggtatctta tagtggtcaa tgtttcagat caggaagaag ttctagagat tgatgttgac
    10801 aaacaagaaa ctctcattag caatacaaat gaaagcgctg ctcttgccaa tcacaaactc
    10861 cagccttggg atgctttttg tattaagata aactaggata gaataagaaa acaacagacg
    10921 ataccactta aaaagtgacg gcctgttgtt tttttaatgt ttgtattaag taataaagcg
    10981 attctgattg actat
//
