LOCUS       CP000449               12531 bp    DNA     linear   BCT 06-SEP-2019
DEFINITION  Maricaulis maris MCS10, complete genome.
ACCESSION   CP000449
VERSION     CP000449.1
DBLINK      BioProject: PRJNA17333
            BioSample: SAMN02598382
KEYWORDS    .
SOURCE      Maricaulis maris MCS10
  ORGANISM  Maricaulis maris MCS10
            Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
            Hyphomonadaceae; Maricaulis.
REFERENCE   1  (bases 1 to 12531)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C., Glavina
            del Rio,T., Hammon,N., Israni,S., Dalin,E., Tice,H., Pitluck,S.,
            Saunders,E., Brettin,T., Bruce,D., Han,C., Tapia,R., Gilna,P.,
            Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Mikhailova,N., Viollier,P., Stephens,C. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Complete sequence of Maricaulis maris MCS10
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 12531)
  AUTHORS   Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,J.C., Glavina
            del Rio,T., Hammon,N., Israni,S., Dalin,E., Tice,H., Pitluck,S.,
            Saunders,E., Brettin,T., Bruce,D., Han,C., Tapia,R., Gilna,P.,
            Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N.,
            Mikhailova,N., Viollier,P., Stephens,C. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (25-AUG-2006) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     URL -- http://www.jgi.doe.gov
            JGI Project ID: 4001624
            Source DNA and bacteria available from Craig Stephens
            (cstephens@csu.edu)
            Contacts: Craig Stephens (cstephens@csu.edu)
            Paul Richardson (microbes@cuba.jgi-psf.org)
            Quality assurance done by JGI-Stanford
            Annotation done by JGI-ORNL and JGI-PGF
            Finishing done by JGI-LANL
            Finished microbial genomes have been curated to close all gaps with
            greater than 98% coverage of at least two independent clones. Each
            base pair has a minimum q (quality) value of 30 and the total error
            rate is less than one per 50000.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
FEATURES             Location/Qualifiers
     source          1..12531
                     /organism="Maricaulis maris MCS10"
                     /mol_type="genomic DNA"
                     /strain="MCS10"
                     /db_xref="taxon:394221"
     gene            1..3036
                     /locus_tag="Mmar10_0253"
     CDS             1..3036
                     /locus_tag="Mmar10_0253"
                     /note="PFAM: TonB-dependent receptor; TonB-dependent
                     receptor, plug; KEGG: sde:Sde_2991 hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q9A608|1.B.14.12.1"
                     /protein_id="ABI64546.1"
                     /db_xref="InterPro:IPR000531"
                     /db_xref="InterPro:IPR010104"
                     /db_xref="InterPro:IPR012910"
                     /translation="MFELRGERRLSRSRLTRALMLSCAVTAFSAPAFAQNDEVEDVVVI
                     QGIRQTIQDSIETKRNSDTVVEALSSDDIGDLPALSIGEALETLTSAASHIEQGGATEI
                     SIRGLGPYLGSTVINGREAANGSGDRSVNFSQFPSELFNSLAVYKTQEASFIEGGVSGQ
                     ISLSTLRPIDYGRSRIQLELKGNYNPDNSDLNISERGIGHRATLSFVDSWETGAGEFGL
                     SFGYQNNRSTNPEQEARTTSSFRDCRNVVSGDPNSDNFGVDSLGDPDQNCDSGGGDLVL
                     EVDPATGVAPDANTPFVFVPSQRHFRQNITDDARDSIFFAAQWQPNARWDINVDYQQSD
                     REFTELRSDLTIDGNSVLNVGESGEIVPLSVSPTGAFLGGTTYDGAEVSSHYMERIEEY
                     TGYGLQAEYQLTDDLTISADYSYSETMRRENIIQSRLRSDTDGDSGSEDVFVGIIVEDD
                     AQRFVFGDFDVTDPANFDVGPRTREDLNQFRNNSIEAFRADFDYLWDNGFITNVRGGVR
                     HSTLEYDSVPRVRRESDGSPLSVGDGAAASAACMNTVFPEDDFLADVVDGPLITNVDSA
                     GNVIANGTGNSYVTFDPLCLAEAILGRAPSIPDASDVFLTSAEMGTGQNPLQIVDVAEE
                     TIAAYLQADFTGEMGELPVRGNFGVRVVDTEVTSNGYRGSLTIDRDGANVITGIGVDNS
                     NLVEITANHSYTEVLPSANLVVELRDDVLLRGGIYRALSRPDPSDLGVGRSFSSSIDND
                     GGSTDVADVIAQVTGFGNPELDPLMSWNYDAALEWYPNEDTILAFGVYYKSFNGGFTNV
                     GQVETFTVDGQDLQAVVTTQSVDSEESTISGFEISAAHAFSYLPGAWSGLGFRVGYNYA
                     DSDFEFEDAVFGASTIIAADGTEIERVGIVAPANVPGLSEHVASAQLYYSIGDLDLQGV
                     YKYRSGYFQQFISTPGNLRYIDERGIYEARASYQVNDAVRVSVEAINIFDEPRVQYNPT
                     LDNFAEVNVYGPRIYFGVRGRF"
     sig_peptide     1..105
                     /locus_tag="Mmar10_0253"
                     /note="Signal predicted by SignalP 2.0 HMM (Signal peptide
                     probabilty 1.000) with cleavage site probability 0.999 at
                     residue 35"
     gene            3250..4011
                     /locus_tag="Mmar10_0254"
     CDS             3250..4011
                     /locus_tag="Mmar10_0254"
                     /note="PFAM: regulatory protein GntR, HTH; GntR domain
                     protein; KEGG: sde:Sde_3287 transcriptional regulator, GntR
                     family"
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|GntR,DBD-SUPERFAMILY|0037767"
                     /protein_id="ABI64547.1"
                     /db_xref="InterPro:IPR000524"
                     /db_xref="InterPro:IPR011711"
                     /translation="MTTDKRLYNQIARRIIALIDDGKFPPGSRLPGERDLAVQLGVSRV
                     TVREAQIALQAQGRIEVRTGSGAKVLPAAPSNDALPTIEAFELTQARTLIESEAAALAA
                     TMINDDELAQLDLLVSKMSDDSENDEALHQDADREFHLTIARASKNAAIIDMIERLWRF
                     RTEIDEIRNAYDSICGISPEMRLSEHRDIALALRARDPDQARAAMRRHFACIVEAMLST
                     AEQRAIEEARRRTSEARERYLGNGESAPQNA"
     gene            4127..6349
                     /locus_tag="Mmar10_0255"
     CDS             4127..6349
                     /locus_tag="Mmar10_0255"
                     /EC_number="4.2.2.3"
                     /note="KEGG: pha:PSHAa1749 alginate lyase precursor"
                     /codon_start=1
                     /transl_table=11
                     /product="PL6|PL6_1"
                     /protein_id="ABI64548.1"
                     /db_xref="InterPro:IPR002086"
                     /translation="MTRTRPQSSWLLRSAVLLLAALAWQPASASATDYLVNDQQAYEAA
                     LDRVEPGDRIVLADGVWEDFEIVFEATGTAQAPIYLMAQTPGQVILTGQSNLRIGGSHL
                     VVWGLTFRDGHSPTSEVIAFRRDSRTLANHTRLVETVIEDFNQPDREMQDSWVVVYGQN
                     NRIDRNAFVGKTNRGPTMVVRLNSEGSQNNNHVIENNYFGPRPPLGGNGGETLRIGVSQ
                     YSRIHSGTIVRRNYFDRCDGEVEIISIKSEGNLITENVFYESRGSVVFRHGGRNEVSRN
                     VFFGNGVSDTGGIRVINDNQVVRDNYLEGLRGRKFLGALVVMNGVPNSPENRYHQVDGA
                     VISQNSFVDVLELGFAVGSDEERSAPPINSEMTRNILLSDEQEPVAIFDDVSGIRFADN
                     VANNRRFDVIGSTALADFTLSRHENGLVYMQSDALDGPVGAPLDLQPIARSQTGPRYYD
                     KPAQTRQDGAAVEVEADEAALLQAIAEAEHGDIIRLGGGDIALSGPILVDQAIAIEGSD
                     DTRLIASPGGLFRLLAGGELTLRGLTLRQESAETALIHGAGDRYRGAYRLHLEDVSLEA
                     GTTGAVAPLLAADSTTFAQLVTLTGLQVTNWPGAIIELSGDGLDGWYLADEIRIEDSSF
                     RTIGGPLVRFGREGRDESTFGPRFSLTGSTLAGVAEDGAAIALNGIDQLHLTGNQIAET
                     GTFQIRRRVLGWPFEIGGNDVDAQASLNLLGVDGEALDASLSGDSQ"
     sig_peptide     4127..4216
                     /locus_tag="Mmar10_0255"
                     /note="Signal predicted by SignalP 2.0 HMM (Signal peptide
                     probabilty 1.000) with cleavage site probability 0.569 at
                     residue 30"
     gene            6346..8514
                     /locus_tag="Mmar10_0256"
     CDS             6346..8514
                     /locus_tag="Mmar10_0256"
                     /note="PFAM: Heparinase II/III family protein; KEGG:
                     sde:Sde_3284 hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="PL17|PL17_2"
                     /protein_id="ABI64549.1"
                     /db_xref="InterPro:IPR012480"
                     /translation="MIRIVGLVAAALLATTSCASAQPNLILTGEGVEAFREAGALPPLM
                     QRALDAATRRVEASIQAGPIVPEPVDPGGGYSHERHKENYKIIHDAGLLFQLTGERRYL
                     EHAETYLLAYADMYGDLPLHPERRNQAPGRLFWQSLNEAVWLVYSIQGYDAIRAELSDA
                     SRDRIEAALFRPMAEFLSTESPQTFQRIHNHGTWAAAAVGMTGYALDDPALVERALFGL
                     ELDGEAGFLAQLDQLFSPDGYYTEGPYYQRYALMPFVLFGQAVQNNEPERGIFEHRDGI
                     LLEAILSTIHQSYAGRFFPINDAIREKGLDTVEVVYGVAAAYSLTGDTGLLSIADQQGA
                     TVLTGDGLAVATDLDAGMASPFAFDTRLLRDGPDGNQGGLAILRMGAGELAQTLVAKHT
                     GQGMGHGHFDKLSLILYDGGQEILTDYGAARFLNVPSKDGGRYLPENSSWARQTIAHNT
                     VVLNETSHHGGDWRRAQESWPSIALFEQRDGVNVVSASISDAYPDATLTRTTFQLQSEN
                     TASPLILDVFDVVADEPSQIDLPTYFAGQLTDFDIAFERFGSQQTALGAGNGYQHLWVE
                     AQSEIAADRARFTWLTENRFYTYHALVSEPFEARIVRTGANDPDFNLRTQQGILLRVPS
                     AESARFISVFEPHGRYDPAQEITVASESGIDEIRSVEGETATLIQIVFNSGQRLSVGLA
                     HDLHAGAHTINADGHRYEWTGAYNIFGE"
     sig_peptide     6346..6411
                     /locus_tag="Mmar10_0256"
                     /note="Signal predicted by SignalP 2.0 HMM (Signal peptide
                     probabilty 1.000) with cleavage site probability 0.936 at
                     residue 22"
     gene            8518..8910
                     /locus_tag="Mmar10_0257"
     CDS             8518..8910
                     /locus_tag="Mmar10_0257"
                     /note="PFAM: Cupin 2, conserved barrel domain protein;
                     KEGG: sde:Sde_3283 diguanylate cyclase/phosphodiesterase
                     (GGDEF & EAL domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|AraC_binding"
                     /protein_id="ABI64550.1"
                     /db_xref="InterPro:IPR007113"
                     /db_xref="InterPro:IPR013096"
                     /translation="MPSANAETVDRTAFDAPSNFVRADVAGAEEVAPGIRRQLLGFGDA
                     LMGARVWFSTGAVGELHAHPHAQMSYVESGEFKVTVGAEQQTLSAGDSFFVPSQSRHGA
                     VCLQAGVLIDVFAPAREDFIPARGEV"
     gene            8910..10232
                     /locus_tag="Mmar10_0258"
     CDS             8910..10232
                     /locus_tag="Mmar10_0258"
                     /note="PFAM: major facilitator superfamily MFS_1; KEGG:
                     pha:PSHAa1746 putative hexuronate transport protein (MFS
                     family)"
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q07YH1|2.A.1.14.25"
                     /protein_id="ABI64551.1"
                     /db_xref="InterPro:IPR007114"
                     /db_xref="InterPro:IPR011701"
                     /translation="MQIPRLRWWIVTLVALATVINYIDRQSLNVLWPEISAELYPDRTE
                     DQRKEIYALISVIFVFAYAFGQAIFGKIFDWIGTRMGFALSIAVWSLATAAHAFARGLG
                     TFALFRAILGAAEAGNWPGATKANAEWFPTKERALAQGIFNSGAAIGGIVSIPLIAFLS
                     VFFDWHIIFIIIGLTGLLWLIPWMVLVKAPPGSHPWVTEDERQYILTGQTRTESEGDSA
                     QTPAESDSYAPGTVELLSRRQSWGVIIASAAIDPIWWLFVFWIPIYLSEVYGFNVREIG
                     IYGWVPYVGAMFGAWFGGLLAQNRIKAGWSVDGARKLTITLGCLIMLPCLLAMSQAANP
                     VVAVLIMAAILFGFQTAIGNVQTLASDFLSGKSVGTLAGFAGMAAKLGAAGLTYLVPWL
                     TMGGNYTPAFIIGAGLALLALASVWIVCGRIEPLKPKKEQA"
     gene            10259..11011
                     /locus_tag="Mmar10_0259"
     CDS             10259..11011
                     /locus_tag="Mmar10_0259"
                     /note="PFAM: short-chain dehydrogenase/reductase SDR;
                     glucose/ribitol dehydrogenase; KEGG: sde:Sde_3281 protein
                     of unknown function DM13"
                     /codon_start=1
                     /transl_table=11
                     /product="short-chain dehydrogenase/reductase SDR"
                     /protein_id="ABI64552.1"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /translation="MKLAGKTAIVVGGGRDIGRAVSISLAREGAKVVVNFNNDEAAAQA
                     TVDDITKAGGDAILVKADATKFAEMEALVASAQSAFGPQIDILATVAGGMVARKTLAEM
                     DEEFFDFVMRLNVHSAFFAMKATVPHMKEGASIINFSSQAGRDGGGPGATAYATGKGAV
                     MTFTRGMAKELGPNGIRVNAVCPGMIATSFHDRFSKDEVREKVAGMTPLRRQGAAEEVG
                     DVVSYLASDEASFLTGVCLDVNGGLLFS"
     gene            11031..12008
                     /locus_tag="Mmar10_0260"
     CDS             11031..12008
                     /locus_tag="Mmar10_0260"
                     /EC_number="2.7.1.45"
                     /note="PFAM: PfkB domain protein; KEGG: sfx:S4209
                     ketodeoxygluconokinase"
                     /codon_start=1
                     /transl_table=11
                     /product="STP|PfkB"
                     /protein_id="ABI64553.1"
                     /db_xref="InterPro:IPR002173"
                     /db_xref="InterPro:IPR011611"
                     /translation="MNAMGHPTKFKADRKAVTCFGEVMAELADLGAEQVRVGVGGDTFN
                     TAVYLARLGTPVRYATALGQDPFSERIRKRMALEGVDAELVATSSDRNCGLYAIEVDET
                     GERSFTYWRSHSAARQFFDLAGARQALDAMAEADVLYLSGITLSLFAESSKTGQIIDLA
                     QSVRRKGGQVVFDTNYRPAGWLSPGQARDTICELMPHISIALPTLEDEQALFGFQSVEE
                     CVEYWCRAGVDEVVVKHGPRGAWSTGVGEWVEPPAIIAPVDTTGAGDSFNAGYLHARLS
                     GASGRESIIAAHQLAALVLGVRGALLPADEPLPAWTKELSKQNV"
     gene            12001..12531
                     /locus_tag="Mmar10_0261"
     CDS             12001..12531
                     /locus_tag="Mmar10_0261"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="ABI64554.1"
                     /translation="MCSPVQRPANIIAPAHLAATYPIGSGIPEIRIDGTVSTVGGLRAS
                     LSRSEGVRLHLEERTRFVLRPQTASTDLTEDVGSEFKPLPRLEGECARLGLLRLLSAPP
                     PLGDRSQFAGVLCTLILWAQEMACELDLRGGVSIGLDRDWAPLLADSHCRWVTMLFGRS
                     LARRVSIEITAAA"
ORIGIN
        1 atgtttgaat tacgagggga gcgtcgtctg tcgcgctcca ggttgacccg tgctctgatg
       61 ttgagctgtg cggtcacagc attttcggcg ccggctttcg cgcagaatga tgaagtcgaa
      121 gacgtcgtcg tcatccaggg gattcggcag accatccagg actcgatcga gaccaagcgc
      181 aattccgaca cggtcgttga agcactgtct tccgacgaca tcggcgacct gccggccctg
      241 tcgattggtg aggcgctgga aaccttgacc agtgcggcct cccatatcga acagggtggc
      301 gcgaccgaga tttccatccg aggcctcggc ccttatcttg gctcgactgt cattaatggc
      361 cgggaagcgg ccaatggcag tggcgaccgt tcagtcaatt tcagccagtt tccatcggaa
      421 ttgttcaact cccttgccgt ttacaagacg caggaagcga gcttcatcga aggtggcgtg
      481 tcgggtcaga tttcgctctc gacccttcgt cccattgatt acggccgtag ccggatccag
      541 ctggagctga aggggaatta caatccggac aattcggatc tgaacatcag tgagcggggc
      601 atcggtcacc gggcgacgct cagcttcgtc gacagttggg agaccggcgc tggcgagttc
      661 ggcctgtcct tcggttatca gaacaaccgc tcgaccaatc ccgaacagga agcgcgcacg
      721 accagttcat tccgtgattg ccgcaatgtt gtctccggag atcccaacag cgataatttc
      781 ggcgtagaca gcctcggtga cccggatcag aactgcgata gcggcggtgg cgatcttgtg
      841 cttgaggtcg atcccgcaac cggtgttgcg ccggacgcga acaccccctt cgtctttgtt
      901 ccgagccagc gccatttccg ccagaacatt acggatgatg cgcgtgactc gattttcttt
      961 gcggcccagt ggcagccgaa cgcgcgctgg gacatcaatg tcgattacca gcagtccgat
     1021 cgcgaattca ctgaactgcg cagtgacctg acgatcgacg gcaactcggt cctgaacgtc
     1081 ggtgaaagcg gcgaaatcgt cccgttgtcc gtgagcccga ccggcgcttt tctgggtggc
     1141 acgacctatg acggcgcaga agtcagctcg cactatatgg agcgcatcga ggaatacacc
     1201 ggctatggat tgcaagccga ataccagctg accgacgatc tgacgatttc ggccgactat
     1261 tcgtattcgg aaacgatgcg gcgcgagaac atcatccagt cacgcttgcg cagtgacacg
     1321 gacggtgact ccggttcaga ggatgttttc gtcggaatta tcgtcgagga cgatgcgcaa
     1381 cggtttgtct tcggggactt tgatgtcacc gatccggcaa actttgacgt cggcccccgt
     1441 acccgggaag acctcaacca gttccgcaac aacagcatcg aagccttccg ggccgacttc
     1501 gactatctgt gggacaacgg gttcatcacc aatgttcgcg gtggtgtccg gcattcaacg
     1561 ctggaatatg attccgtgcc tcgcgtgcgc cgcgagagcg atggcagccc gctctctgtg
     1621 ggtgatggtg cggcggcaag cgcggcctgc atgaacactg tcttcccgga agatgacttc
     1681 cttgcggacg tcgtggatgg cccgctgatc acgaatgtcg acagtgccgg gaatgtcatc
     1741 gccaacggca ccggtaactc ctatgtgact ttcgacccgc tgtgccttgc cgaggccatc
     1801 ctgggtcgtg caccgagtat cccggatgcg agcgatgtct ttttgacctc ggctgaaatg
     1861 ggtaccggtc aaaacccgct ccagattgtc gatgttgcgg aagaaacgat cgctgcctat
     1921 ctgcaggccg actttaccgg agaaatgggt gagctgcccg tgcgcggtaa ttttggtgtt
     1981 cgtgtggtgg atacggaagt cacgtcgaac gggtatcgcg gttcgctgac gattgaccgc
     2041 gacggggcca atgtcatcac cggcatcggc gtcgacaaca gcaatctcgt cgagatcacg
     2101 gccaatcaca gctataccga ggttctgccg agcgcgaacc tggttgtgga gctgcgcgat
     2161 gacgtgctgt tgcgcggtgg catctaccgt gcgctgtcgc gtccggaccc gtccgatctg
     2221 ggtgtggggc gcagcttctc gagcagcatc gacaatgacg gcgggtcgac cgacgtggcc
     2281 gatgtcatcg cccaggtcac cggcttcgga aacccggagc tcgaccctct gatgtcgtgg
     2341 aattatgacg cggcgctcga atggtatccc aatgaggaca ccattctggc cttcggggtc
     2401 tactacaaga gcttcaatgg tggtttcaca aacgtcgggc aggtggagac tttcaccgtc
     2461 gacggccagg acctccaggc tgttgtcacg acccagtcgg tagacagcga ggagagcacg
     2521 atttcaggct ttgaaatctc ggcagcgcac gccttcagct acctgccggg tgcctggagc
     2581 ggtctcggct tccgggtcgg atacaactac gccgactctg atttcgagtt cgaagatgcc
     2641 gtctttggtg cgtcgacgat catcgccgcc gatggcaccg agatcgaacg ggtcggaatc
     2701 gtggcgccag ccaatgtccc cggcctgtcg gagcatgtcg catcggcgca gctgtactac
     2761 agcatcgggg atctcgatct gcagggtgtc tacaaatatc gtagtggcta cttccagcag
     2821 ttcatctcga cgccgggcaa tctgcgctac atcgacgaac gcggcatcta cgaagcccgc
     2881 gcctcgtatc aggtcaatga tgcggtgcgt gtcagcgttg aggcgatcaa tatctttgac
     2941 gagccgcggg tccagtacaa tccgaccctc gacaacttcg ctgaagtcaa tgtctacgga
     3001 ccccgtatct acttcggagt gcgggggcgg ttctaatcga ccgtcgtgac tttgcggact
     3061 tcccccttgc cctcaagggg actgtggcgc ctcctggtgc ccggcttagc cgggcgccag
     3121 cggggcgccg cttcattcgc gggtatggcc tggaaaattt gtagtccaat tacgataatg
     3181 ctatgatttt caggtggtcc gagcgatcgg gccgaatctt gagaatggtc agaaacggca
     3241 tcaaacaaaa tgacaacaga taagcgcctg tacaaccaga tcgcccgccg catcatcgcc
     3301 ctgattgatg atggcaaatt ccctccggga agccgcttgc caggtgagcg ggatctcgcg
     3361 gtacagctgg gcgtcagtcg ggtgaccgtg cgcgaggcgc agatcgcttt gcaggcgcag
     3421 gggcggatcg aggtgcggac cggttccggc gcaaaagtat tgccggcggc cccttccaat
     3481 gacgcgttgc caacaatcga ggccttcgaa ttgacccagg cgcggacgct gatcgaaagc
     3541 gaagcggccg ccctggcagc gacgatgatc aatgatgacg agctggcaca actcgacctg
     3601 ttggtgtcga aaatgtcaga tgacagcgag aatgacgaag cgttgcatca ggacgcggac
     3661 cgtgaatttc acctgacgat cgcgcgggcc tcaaagaatg ccgcgatcat cgacatgatc
     3721 gagcgtttgt ggcgctttcg caccgaaatt gatgaaattc gcaatgccta tgactccatc
     3781 tgcggcattt ccccggagat gcgactgtca gagcatcgcg atattgccct tgcgctgcgg
     3841 gcgcgggatc cggaccaggc ccgggcggcc atgcgtcggc actttgcctg catcgtcgag
     3901 gcgatgctca gcacagccga gcagagggcc atcgaagaag cccggcgccg caccagcgag
     3961 gcgcgtgagc gctatcttgg gaacggtgaa agcgccccgc aaaatgctta ggccaattgc
     4021 ctaggccatt ttgaacaaat tggactgtga aacctcttgt ccgcttgatc gcgggtggtt
     4081 atgctccctc ttgaagcttc atcaatagaa gcaaagcgga ggaagtatga cccggacccg
     4141 accccagtct tcgtggctgt tgcgcagcgc tgtgctcctt ttggcggcct tggcctggca
     4201 accggcctcc gcatccgcga ccgactacct cgtcaatgat cagcaggcct atgaggccgc
     4261 gctggaccgg gttgagccgg gcgaccggat tgtgctcgca gacggtgtct gggaggactt
     4321 cgaaatcgtg tttgaggcga ccggcacggc ccaagcaccg atctacctga tggcgcagac
     4381 gccggggcag gtcattctca ctggtcagtc caatttgcgg attggtggct cgcacctcgt
     4441 cgtgtggggg ctgaccttcc gtgacggtca ttcgccgaca agcgaagtga ttgccttccg
     4501 gcgcgacagc cggacgctgg caaatcatac ccgcctggtg gaaaccgtga tcgaggactt
     4561 caaccagccg gaccgcgaaa tgcaggattc ctgggttgtc gtctatgggc agaacaatcg
     4621 catcgaccgg aacgcctttg tcggcaagac caaccggggt ccgaccatgg tggtgcgcct
     4681 caattccgag ggcagccaga acaacaacca tgtgattgaa aacaattatt tcgggccgcg
     4741 cccgccactc ggcgggaatg gcggcgaaac cctgcgaatt ggcgtcagcc agtactcacg
     4801 aatacattcg ggcaccatcg tccggcggaa ttattttgat cgttgcgatg gcgaggtcga
     4861 aatcatctcg atcaagtccg aaggcaatct gatcacggag aacgtgttct acgaatcgcg
     4921 cgggtccgta gtcttccgcc atggcgggcg caacgaagtg tcgcggaatg tattcttcgg
     4981 gaacggggtt tccgataccg gtggcatccg cgtcatcaat gataatcagg tggtgcgcga
     5041 caattatctg gaaggtttgc gtggtcgcaa attcctcggc gccctggtgg tgatgaatgg
     5101 cgtgccgaat tcaccggaga accgatacca tcaggttgat ggcgcggtga tcagccagaa
     5161 cagcttcgtt gacgtgctcg agctgggctt cgctgttggc agcgatgaag agcgcagcgc
     5221 gccgcctatc aacagcgaaa tgacgcgcaa tatcctgctg tcagacgagc aggagcccgt
     5281 cgccattttc gacgatgtgt ccggtatccg gtttgctgac aatgtcgcca acaatcgtcg
     5341 tttcgacgtg attggctcca ctgccctggc cgacttcacc ctgtcccgcc acgaaaacgg
     5401 gctcgtctat atgcaaagcg atgcgctgga cggtccggtc ggtgcgccgc tcgaccttca
     5461 gccgatcgcc cgcagccaga ccgggccacg ctattacgac aagccggccc agacccgaca
     5521 ggacggcgct gctgtcgagg tcgaggccga tgaggcggcc ctgttgcagg caattgccga
     5581 agctgagcac ggggatatca ttcgactggg aggtggtgac attgcgcttt ccggaccaat
     5641 cctggtcgat caggccattg ccatcgaggg cagtgacgac acccggttga tcgcatcgcc
     5701 gggtggtctg ttccgtctgc ttgccggcgg cgagctgacg cttcgcggcc tcaccctgcg
     5761 ccaggaaagt gccgagacgg cactgatcca tggcgccgga gaccggtacc gaggcgctta
     5821 ccgacttcac ctcgaggacg tcagcctcga ggccggcacc acgggcgccg ttgccccctt
     5881 gctcgctgct gacagcacaa catttgccca gcttgtcacc ctgaccggac tgcaggtcac
     5941 caactggccg ggtgcgatca tcgaactgag tggggacggg cttgacggct ggtacctggc
     6001 cgatgaaatc cgcattgagg acagttcgtt ccgcacaatc ggtggtccat tggtccggtt
     6061 tggccgcgaa ggccgcgatg agagcacctt tggtccgcgc ttcagcctga caggctcgac
     6121 gctggcaggg gtggccgagg acggtgcggc gatcgcactg aacggaatcg accaactgca
     6181 cctgacaggc aatcagatcg ccgagacggg caccttccag atccgccgtc gtgtgctggg
     6241 ttggccgttc gagatcggcg gcaatgacgt cgatgcccag gccagcttga acctcctcgg
     6301 tgtcgatggt gaggcgctgg atgcaagcct ctcgggtgac agccaatgat ccggattgtc
     6361 ggactggtcg ctgccgcctt gctggcaacg acctcctgcg cgtcggcgca gccaaacctg
     6421 atcctcacgg gcgagggcgt tgaagccttc cgtgaagcgg gggcgctgcc gccactgatg
     6481 caacgggccc tggacgccgc aacgcgacgg gtggaggcca gcatccaggc cggcccgatt
     6541 gtcccggagc ctgtcgatcc cggtggcggt tattcgcacg agcgccacaa ggaaaactac
     6601 aagatcatcc acgatgccgg cttgctcttt cagcttaccg gagagcggcg ctatctcgag
     6661 catgccgaga cctacctgct ggcctatgcg gacatgtatg gtgacctgcc attgcaccct
     6721 gagcgtcgca accaggcgcc gggccggttg ttctggcaaa gcctgaacga agctgtctgg
     6781 ctggtctatt cgatccaggg ctatgacgcg atccgagctg aactctctga tgcgtcgcgc
     6841 gatcgcatcg aggcggccct gttccgtccc atggcagaat tcctgtcgac agagtcgccg
     6901 cagactttcc aacgcatcca caatcacggc acctgggccg ctgcagccgt cggcatgacc
     6961 ggctatgcgc tggacgatcc tgcgcttgta gagcgtgcgc tgtttgggct cgagctcgac
     7021 ggtgaggcag gctttttggc ccagctcgac cagctttttt caccggacgg gtactacact
     7081 gagggcccct attatcaacg ctacgcactc atgccgttcg tgttgttcgg acaggcggtg
     7141 cagaataacg agcccgagcg gggcatattc gagcatcgcg acggcatttt gctcgaagcc
     7201 atcctttcga ccatccacca gagctatgcg ggccgtttct ttccgatcaa tgatgcgatc
     7261 cgggaaaagg gtctcgacac ggttgaggtc gtctacgggg tcgcggccgc ctactccctg
     7321 acgggagata ccggtctgct gtcgattgcc gatcagcagg gcgcgacggt tctgaccggc
     7381 gacgggctgg ccgtggcgac cgaccttgat gccggaatgg cctctccctt tgcctttgac
     7441 acacgactgc ttcgcgatgg ccctgacgga aatcagggcg gccttgccat cctgcgcatg
     7501 ggcgcgggag agctcgcgca gacgcttgtg gccaagcaca ccggtcaggg catggggcac
     7561 gggcatttcg acaagctgtc gctcattctc tacgacggcg gacaggagat cctgaccgat
     7621 tatggcgccg cccgcttctt gaatgtcccc tccaaggatg gtggacgtta tctgccggag
     7681 aacagcagct gggcccgcca gaccattgcc cacaataccg tggtcctgaa cgagaccagc
     7741 catcatggcg gtgactggcg tcgcgctcag gagagctggc cgagcattgc cctgttcgag
     7801 cagcgcgatg gcgtcaatgt ggtttcggcg agtatctcag atgcctatcc ggatgcgacg
     7861 ctgacccgaa ccactttcca gctgcagagt gaaaacaccg ccagtccgct catcctggac
     7921 gtctttgacg ttgttgccga cgagccgtcg caaattgacc tgcccaccta tttcgctggc
     7981 cagctgacgg atttcgatat cgcgtttgaa cgcttcggaa gtcagcaaac ggcgctgggg
     8041 gcgggcaatg gctatcagca tttgtgggtg gaagcccaaa gcgagattgc ggccgatcgg
     8101 gcacgcttca cctggctgac ggaaaaccgg ttctacacct atcatgccct ggtcagcgag
     8161 ccgttcgagg ctcgaattgt cagaaccggc gcgaacgatc ccgatttcaa tctccggacc
     8221 caacagggca tcctgttgcg tgttcccagc gcggaatcag cccgtttcat ttcggtgttc
     8281 gaaccgcatg gtcgatacga cccggcccag gaaatcacgg tcgcgagcga gagcggcatt
     8341 gacgagatcc gttccgttga aggcgagacc gccacgctca tccagatcgt tttcaactca
     8401 ggtcaacgcc tcagcgttgg cctggctcat gatctccatg ccggagctca cacgataaac
     8461 gccgacggcc atcgttacga atggaccggg gcttacaaca tatttgggga gtgaatcatg
     8521 ccgtcagcga atgcggaaac ggtcgatcgg accgcttttg atgcgccatc gaatttcgtc
     8581 agggccgatg tcgccggggc ggaggaggtc gcgccgggaa ttcgacgcca actcctcggt
     8641 ttcggggatg ccctcatggg cgcccgggtc tggttttcga cgggggctgt tggcgaactt
     8701 cacgcccatc cccatgcgca gatgtcctat gtcgaatccg gtgaattcaa ggtcaccgtc
     8761 ggcgccgaac aacagaccct gtccgctggc gacagcttct tcgttccatc ccaaagccgg
     8821 cacggtgctg tctgcctgca agcgggtgtc ctgatcgatg tgtttgcgcc agcccgcgaa
     8881 gacttcattc cggcacgggg agaggtctga tgcaaattcc ccgacttcgc tggtggattg
     8941 tcaccctggt cgcgctggcg accgttatca actatatcga ccggcaatcg ctgaatgtcc
     9001 tctggccgga aatttcggcg gaactctatc ctgaccggac cgaagaccag cgaaaggaaa
     9061 tctacgccct tatctcggtc atcttcgtgt tcgcatacgc gttcggacag gcgattttcg
     9121 gaaagatttt cgactggatc ggcacccgaa tggggtttgc cctgtcgatt gcggtctggt
     9181 cgctggccac ggcggcccat gctttcgccc gaggtttggg aacctttgcg cttttccgtg
     9241 cgatcctggg cgccgccgag gccggtaact ggccgggcgc gaccaaggcc aatgccgaat
     9301 ggtttccgac caaggaacgt gcgctcgcgc agggcatttt caattccggt gccgcgattg
     9361 gcggcattgt ttcgatcccg ctcattgcgt tcttgtcggt gtttttcgac tggcacatca
     9421 ttttcatcat catcggcctg accggcttgc tctggctcat tccgtggatg gttctggtca
     9481 aggcgccccc aggttcccac ccgtgggtca ccgaggatga acgccaatat attctgactg
     9541 gccagacccg cacggaaagc gagggtgaca gcgctcaaac accggctgaa tcagatagct
     9601 acgcaccggg gacggtagag cttttgtcgc ggcggcagag ctggggtgtc atcatcgcct
     9661 ctgcggcgat cgatccgatc tggtggttgt ttgtcttctg gatcccgatc tacctatctg
     9721 aagtctatgg cttcaacgtc cgtgaaatcg gcatctacgg ctgggtccct tatgtcggcg
     9781 ccatgttcgg agcctggttc ggtggcttgc tggcccagaa ccggatcaag gccggctgga
     9841 gtgtcgatgg cgctcgcaaa ctgaccatca cgctcggttg cctgatcatg cttccctgtc
     9901 tgcttgcgat gtcacaggcg gccaatccgg tcgtcgcggt cctgatcatg gcggcgatcc
     9961 tgttcggctt ccagaccgcc attggcaacg tgcagacgct ggccagtgac ttcctcagtg
    10021 gcaagtcggt tggcacgctg gccggattcg ccggaatggc cgccaagctg ggcgctgccg
    10081 gtctgaccta tctcgtgccg tggctgacga tgggtggcaa ctacacgcct gctttcatca
    10141 ttggtgcagg tctcgccctg ctggctctgg ccagcgtgtg gatcgtgtgt ggccggattg
    10201 aacctctcaa accgaaaaaa gaacaagcct gacggcttcc agattctagg agacgaaaat
    10261 gaaactcgcc ggaaaaaccg cgattgttgt tggtggtggc cgtgatatcg ggcgtgccgt
    10321 ctcgatcagc ctggcccgcg aaggcgccaa ggtggtcgtc aatttcaaca atgatgaagc
    10381 cgccgcccaa gcgacagttg atgatattac caaggctggc ggcgacgcca tcctggtcaa
    10441 ggctgatgcg accaaattcg ccgagatgga agcgctcgtg gcgtcagccc aaagcgcctt
    10501 cggcccgcaa atcgacattc tcgcgactgt cgccggcggc atggtggccc gcaagaccct
    10561 cgccgaaatg gacgaggagt tttttgactt cgtcatgagg ctcaatgtgc actcggcatt
    10621 cttcgcgatg aaagcgaccg tgccgcacat gaaggaaggg gcgtcgatca tcaacttttc
    10681 ctcccaggct ggccgtgatg gcggggggcc cggtgctacc gcctacgcga cgggcaaggg
    10741 cgccgtcatg acattcaccc gcggcatggc caaggagctt ggcccgaacg gaattcgggt
    10801 caacgccgtg tgcccgggca tgattgccac cagcttccat gaccgtttct cgaaggatga
    10861 agtgcgcgag aaggtggccg gcatgacgcc gcttcgtcgc cagggtgcag ccgaggaagt
    10921 gggcgatgtg gtcagctatc tggcctcgga tgaagcttcc ttcctgacgg gcgtttgcct
    10981 cgacgtgaat ggcggtttgc tgttctccta ggcttcaagg cagctgaaag atgaatgcga
    11041 tggggcatcc gaccaagttc aaggctgacc gcaaagcggt cacctgcttt ggcgaggtca
    11101 tggcagagct cgcagatctg ggcgcggaac aggtccgtgt cggtgttggc ggcgatacct
    11161 tcaacacggc ggtttacctg gcccggctcg gaacgccggt tcgctatgca acggcactgg
    11221 gccaggaccc gttcagcgag cggatacgca aacgcatggc gctcgagggt gtggacgctg
    11281 agctggtcgc aacctcaagc gatcgcaatt gcggcctgta cgcgattgaa gtcgacgaga
    11341 cgggagagcg gagcttcacc tattggcgct cgcacagcgc ggcgcgccag ttcttcgatc
    11401 ttgccggggc ccgacaggcg ctggatgcga tggcagaggc cgatgtgttg tacctctccg
    11461 gcataacact gtcgctcttt gcggaatcgt cgaagacggg acagatcatc gatctggcgc
    11521 aatctgttcg ccgaaagggt gggcaagtcg ttttcgacac caactaccgt cccgccggct
    11581 ggctttcgcc agggcaagcg cgggacacaa tctgcgagtt gatgccgcac atctccatcg
    11641 ccctgcccac gctcgaagat gagcaggccc tgttcggctt ccagagcgtc gaggaatgtg
    11701 tggaatactg gtgccgcgcc ggcgttgacg aagtcgtcgt caagcacggt cctcgaggcg
    11761 cctggtcgac gggcgttggg gaatgggtcg agccgccggc aattattgcg ccggttgaca
    11821 ccacaggtgc cggggacagt ttcaatgccg gctatctcca cgcacgcctg agcggcgcgt
    11881 ccggccggga atcaatcata gccgcgcatc aattggccgc attggtcctg ggagtacgcg
    11941 gcgcactgct accggcggat gagccactcc cggcctggac gaaggagctg agcaaacaga
    12001 atgtgtagtc ccgttcaacg ccccgccaat atcattgcgc ctgcccacct tgccgcgact
    12061 tatccgatcg ggtccggcat tcccgaaatc cgcatcgacg gcacggtttc gaccgtgggc
    12121 gggctgcgcg cgagcctgtc gcgctccgag ggtgttcggc tgcatcttga agagcggacc
    12181 cgcttcgtct tgaggcccca gacagcgtca accgacctga ccgaggacgt cgggagtgag
    12241 ttcaaaccgc tgccccgtct cgagggggaa tgcgcaagat tgggccttct cagattgctg
    12301 agcgcaccgc ctccactggg cgaccggtca caatttgccg gtgtcctttg caccctgatc
    12361 ttgtgggctc aggaaatggc ttgtgaactg gacctgcgcg gcggggtgag catcggtctg
    12421 gatcgcgact gggcgccctt actggccgac tcccattgcc gatgggtcac catgctcttc
    12481 ggtcgttcat tggcgcgccg ggtgtcgatt gagataaccg ctgcggcctg a
//
