LOCUS       NZ_AAYG02000020        13429 bp    DNA     linear   CON 19-DEC-2019
DEFINITION  [Ruminococcus] gnavus ATCC 29149 R_gnavus-1.0.1_Cont169, whole
            genome shotgun sequence.
ACCESSION   NZ_AAYG02000020
VERSION     NZ_AAYG02000020.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN00627102
            Assembly: GCF_000169475.1
KEYWORDS    WGS; RefSeq.
SOURCE      [Ruminococcus] gnavus ATCC 29149
  ORGANISM  [Ruminococcus] gnavus ATCC 29149
            Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae;
            Blautia.
REFERENCE   1  (bases 1 to 13429)
  AUTHORS   Sudarsanam,P., Ley,R., Guruge,J., Turnbaugh,P.J., Mahowald,M.,
            Liep,D. and Gordon,J.
  TITLE     Draft genome sequence of Ruminococcus gnavus (ATCC 29149)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 13429)
  AUTHORS   Fulton,L., Clifton,S., Fulton,B., Xu,J., Minx,P., Pepin,K.H.,
            Johnson,M., Thiruvilangam,P., Bhonagiri,V., Nash,W.E., Mardis,E.R.
            and Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-APR-2007) Genome Sequencing Center, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
REFERENCE   3  (bases 1 to 13429)
  AUTHORS   Fulton,L., Clifton,S., Fulton,B., Xu,J., Minx,P., Mardis,E.R. and
            Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-MAR-2007) Genome Sequencing Center, Washington
            University School of Medicine, 4444 Forest Park, St. Louis, MO
            63108, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/11/2019 13:36:17
            Annotation Pipeline               :: NCBI Prokaryotic Genome
            Annotation Method                 :: Best-placed reference protein
            Annotation Software revision      :: 4.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
            Genes (total)                     :: 3,502
            CDSs (total)                      :: 3,434
            Genes (coding)                    :: 3,285
            CDSs (with protein)               :: 3,285
            Genes (RNA)                       :: 68
            rRNAs                             :: 2, 2, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 63 of 149
            Pseudo Genes (incomplete)         :: 84 of 149
            Pseudo Genes (internal stop)      :: 14 of 149
            Pseudo Genes (multiple problems)  :: 12 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence was derived from
            AAYG02000020.
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotation Pipeline
            set; GeneMarkS-2+
            repeat_region
FEATURES             Location/Qualifiers
     source          1..13429
                     /organism="[Ruminococcus] gnavus ATCC 29149"
                     /mol_type="genomic DNA"
                     /strain="ATCC 29149"
                     /isolation_source="biological product [ENVO:02000043]"
                     /host="Homo sapiens"
                     /type_material="type strain of Ruminococcus gnavus"
                     /db_xref="ATCC:29149"
                     /db_xref="taxon:411470"
     gene            1..405
                     /locus_tag="RUMGNA_RS11830"
                     /old_locus_tag="RUMGNA_02690"
     CDS             1..405
                     /locus_tag="RUMGNA_RS11830"
                     /old_locus_tag="RUMGNA_02690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005333221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|MerR,DBD-SUPERFAMILY|0042546"
                     /protein_id="WP_004843624.1"
                     /translation="MTIKEVSEKYQITQDTLRYYERIGMIPAVPRTSGGIRNYGEADLG
                     WIELALCMRNAGLPVESMIEYVHLFQEGDETIPARLHLLLEQKEHLIEQQNKISQMLKR
                     LEYKISRYEEAVQTGKLVWNEDKAEECRKR"
     gene            complement(532..1428)
                     /locus_tag="RUMGNA_RS11835"
                     /old_locus_tag="RUMGNA_02691"
     CDS             complement(532..1428)
                     /locus_tag="RUMGNA_RS11835"
                     /old_locus_tag="RUMGNA_02691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005330749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="WP_004843625.1"
                     /translation="MKKYISIDIGGTAIKYGIICENAEIILKETLRTEAWKGGPAILKK
                     VIGIVEHLIEQTKGKISGICISTAGMVDTKSGSIFYSAPLIPDYAGMEFKKTLEDKFHI
                     PCEVENDVNCAGLAEYSSGAAKGCRVVLMLTIGTGIGGCIVLDGKVFHGFSNSACEVGY
                     MHMDGSDFQTLGAASILSKKVSQWKGDSEDKWDGYHIFEEAKKGDMICNRAIDQMAEIL
                     GKGIANICYVINPEIVVLGGGIMAQEEFLRGKIQNSVKKYLISSIEECTKIVFAKHQND
                     AGILGAFYHFCGVNKKL"
     gene            complement(1578..2495)
                     /locus_tag="RUMGNA_RS11840"
                     /old_locus_tag="RUMGNA_02692"
     CDS             complement(1578..2495)
                     /locus_tag="RUMGNA_RS11840"
                     /old_locus_tag="RUMGNA_02692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006427785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylneuraminate lyase"
                     /protein_id="WP_024854133.1"
                     /translation="MRNLEKYKGVIPAFYACYDKEGNISPEGVQGLTKYFVKKGVKGVY
                     VNGSSGECIYQSVEDRKIVLENVMKVAEGKLTVIAHVACNNTKDSQELARHAEGLGVDA
                     IAAIPPIYFHLPEYAIAQYWNAISAAAPNTDFVIYNIPQLAGVALTQNLFVEMRKNPNV
                     IGVKNSSMPVQDIQMFKQAAGAEYIIFNGPDEQFMSGRVIGAEGAIGGTYGAMPELYLK
                     LDECINAGKMTEARKIQYACNEIIYKMCSAHGNMYAVIKAILKINEGLELGAVREPLPA
                     LVDEDMEIVKEAAQMICDAKKKFL"
     gene            complement(2543..3232)
                     /locus_tag="RUMGNA_RS11845"
                     /old_locus_tag="RUMGNA_02693"
     CDS             complement(2543..3232)
                     /locus_tag="RUMGNA_RS11845"
                     /old_locus_tag="RUMGNA_02693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015529448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="WP_024854132.1"
                     /translation="MYQKVANLKGKLIVSCQALPNEPLHSSFIMGRMALAAKEGGARGI
                     RANSKEDIKEIRSKVDLPIIGIVKRDYEDSAVYITPTMKEIEELMEVKPDIIAMDATIS
                     KRPSNQTLDEFFHEVKEKYPNQLWMADCSTIEEALHADDLGFDFIGTTLVGYTEQSKGD
                     KIEKNDFEILREIIAGVKHKVIAEGNINTPQKARHVIELGAYSVVVGSIITRPQLITKS
                     FVEEMER"
     gene            complement(3343..5514)
                     /locus_tag="RUMGNA_RS11850"
                     /old_locus_tag="RUMGNA_02694"
     CDS             complement(3343..5514)
                     /locus_tag="RUMGNA_RS11850"
                     /old_locus_tag="RUMGNA_02694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008680620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH0|GH33|CBM40"
                     /protein_id="WP_004843631.1"
                     /translation="MNKYKKIVSIAATAVMCVAPMSVYAQEAQTDVIEAVAEKKQDTES
                     SSVPVLQKEGIEISEGTGYDLSKEPGAATVKALEQGTIVISYKTTSENAIQSLLSVGNG
                     TKGNQDRHFHLYITNAGGVGMELRNTDGEFKYTLDCPAAVRGSYKGERVSNTVALKADK
                     ENKQYKLFANGELIATLDQEAFKFISDITGVDNVMLGGTMRQGTVAYPFGGSIERMQVY
                     RDVLSDDELIAVTGKTIYAENIFYAGDATKSNYFRIPSLLALDSGTVIAAADARYGGTH
                     DAKSKINTAFAKSTDGGKTWGQPTLPLKFDDYVAKNIDWPRDSVGKNVQIQGSASYIDP
                     VLLEDKETHRVFLFADMMPAGIGSSNASVGSGFKEVDGKKYLKLHWKDDAAGTYDYSVR
                     ENGTIYNDTTNSATEYSVDGEYNLYKNGNAMLCKQYDYNFEGTKLLETQTDTDVNMNVF
                     YKDADFKVFPTTYLAMKYSDDEGETWSDLQIVSTFKPEESKFLVLGPGVGKQIANGEHA
                     GRLIVPLYSKSSAELGFMYSDDHGNNWTYVEADQNTGGATAEAQIVEMPDGSLKTYLRT
                     GSGYIAQVMSTDGGETWSERVPLTEIATTGYGTQLSVINYSQPVDGKPAILLSAPNATN
                     GRKNGKIWIGLISETGNSGKDKYSVDWKYCYSVDTPQMGYSYSCLTELPDGEIGLLYEK
                     YDSWSRNELHLKNILKYERFNIDELKVQP"
     gene            complement(5511..6635)
                     /locus_tag="RUMGNA_RS11855"
                     /old_locus_tag="RUMGNA_02695"
     CDS             complement(5511..6635)
                     /locus_tag="RUMGNA_RS11855"
                     /old_locus_tag="RUMGNA_02695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018593842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_004843633.1"
                     /translation="MKTVGYAIVGTGYFGAELGRIMKEQEGARIVAVLDPENGQTIAEE
                     LDCDVETDLDTLYSREDVEAVIVATPNYLHKEPVIKAAEHGVNVFCEKPIALSYQDCDE
                     MVRTCQEHGVIFMAGHVMNFFHGVRYAKKLINDGVIGKVLYCHSARNGWEEQQPTISWK
                     KIREKSGGHLYHHIHELDCVQFLMGGMPEEVTMTGGNVAHQGEAFGDEDDMLFVNMQFS
                     DNRYAVLEWGSAFHWPEHYVLIQGTKGAIKIDMCDCGGTLKVDGREEHFLVHESQEEDD
                     DRTRIYHGTEMDGAIMYGKPGKKPPMWLHSIMKNEMKYLNGILHGKEVDDEFRPLLTGE
                     AARAAIATADACTKSRFEDRKVKLSEIIGEGSTI"
     gene            complement(6657..7490)
                     /locus_tag="RUMGNA_RS11860"
                     /old_locus_tag="RUMGNA_02696"
     CDS             complement(6657..7490)
                     /locus_tag="RUMGNA_RS11860"
                     /old_locus_tag="RUMGNA_02696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008752303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72H66|3.A.1.1.25"
                     /protein_id="WP_039959879.1"
                     /translation="MMNRKGKVGNAFCHLYLIILSLIAFFPLVWILLCSVKASGELTSN
                     PTRFLPKHFTLDNFTHVIQDLGFAKNIGNSLFIAIITTCIAIVISSMAAYGIVRFFPKL
                     GSIMSKVLVATYMFPPILLAIPYSMVMAKLGLVNTRIGLIIVYLSFSVPYAVWMLVGFF
                     KTVPLGIEEAARVDGANKFQTFVQIVLPLVMPGIVATAIYTFINAWNEFLYSLILINST
                     DKMTVSVALKSLQGAEILNWGDMMAASTLVVVPSVIFFMFIQNKIAGGMTDGAVK"
     gene            complement(7490..8377)
                     /locus_tag="RUMGNA_RS11865"
                     /old_locus_tag="RUMGNA_02697"
     CDS             complement(7490..8377)
                     /locus_tag="RUMGNA_RS11865"
                     /old_locus_tag="RUMGNA_02697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008752304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q72H67|3.A.1.1.25"
                     /protein_id="WP_039959892.1"
                     /translation="MKRKEKVDYARWIFVLPALLVVGVLLIYPIFSSLYYSMTSKHLIR
                     LTYDFIGMANYKEVLTDPNFYKAFLNSILWTIGSLLGQLFIGFTAALAINRVKVGKGIY
                     RTLMIIPWAFPSIVIALSWKWILNGVSGFIPNMLVQLGICSELPQFLSDSSLVFLTLIF
                     INVWFGAPMIMVNVLSALQTIPQDQYEAAQIDGASKFQQFWFITVPHIKIVVGLLVVLR
                     TIWVFNNFDIIYLLTGGGPANATTTMPIYAYNMGWNTKLLGRSSAVTMLLLAFLLLVCV
                     VYFTIIAKWEKEDK"
     gene            complement(8426..9763)
                     /locus_tag="RUMGNA_RS11870"
                     /old_locus_tag="RUMGNA_02698"
     CDS             complement(8426..9763)
                     /locus_tag="RUMGNA_RS11870"
                     /old_locus_tag="RUMGNA_02698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008755156.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STP|SBP_bac_1"
                     /protein_id="WP_004843638.1"
                     /translation="MKKKTAILLAGTMIASTILAGCGSKEEGAANQVASEELKGDITFW
                     HSFTQGPRLEVIQETADQFMKDNPGVNIKIETFSWGDFYTKWTTGLASGNVPDMSTALP
                     GHVVEMMNADALVPVDDLIDDIGRDKFSKTALSEGEKDGECYSLPLYSHAQVMWYRKDL
                     LEEAGLSVPKTWDEFAEAAKTLTKDGVYGCSFPCGSNDLMATRFLNFYVRSGGGSLLTD
                     DLKADLTSDLAIDGIKYWLDIYKNCSPKDSVNYAVLDQANLFYQGKTAFDFNSGFQISG
                     VETNSPDLIDQIDCAPLPKLNADDPDYGAETSNIPMVIWRNSKHPEICKAFMKKLYERD
                     TYIKFLDATPVGMLPSISGISDTPEYKENETVQKFSNAVDVITDAMEKGTAIGYEHGPS
                     IQAGFLTSQGIIESMFQDIITNGTDVKKAAKTAEKQLNELFSTVQQ"
     gene            complement(9915..10763)
                     /locus_tag="RUMGNA_RS11875"
                     /old_locus_tag="RUMGNA_02699"
     CDS             complement(9915..10763)
                     /locus_tag="RUMGNA_RS11875"
                     /old_locus_tag="RUMGNA_02699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009220042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DBD-Pfam|HTH_AraC,DBD-Pfam|HTH_AraC,DBD-SUPERFAMI
                     LY|0036286,DBD-SUPERFAMILY|0035607"
                     /protein_id="WP_101883549.1"
                     /translation="MVDNIRFTFLYIEFYSMGRTWVYPESVIPYSIFRYIEKGKAELCI
                     DGEEIIVEENQIVYIPQGCKMSCRALGESFEFYSLRFTTSVFYEGEDMLAEYYGIPRVS
                     VNEGEDVYFKEIYKWVKKDSMVKKCFVRGNLDLLIGSLAMHGNKVDKVTGDFVETIEEK
                     SLRDRNSKKNEQIDPRIYIVADYIILHPSEKYTPQKMAEMADLSKQRFSSLFKINMGKT
                     PMEYVREIRLTTAARALLVSNDNINDIAYACGYEDTNYFIREFKSAFGFTPNQYRKVAR
                     E"
     gene            complement(10906..11355)
                     /locus_tag="RUMGNA_RS11880"
                     /old_locus_tag="RUMGNA_02700"
     CDS             complement(10906..11355)
                     /locus_tag="RUMGNA_RS11880"
                     /old_locus_tag="RUMGNA_02700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004082600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="WP_004843641.1"
                     /translation="MIFDSIQNKENYKEDRKIYQALCYLAEIKRWEEAFPDTVIQKGVI
                     VANPVSFVSKEEKECMYEAHQKYIDVHYIIEGVERIATADVSSLQIQTPFSEEKDIGFY
                     QGDESGGYLLKAGEFMVCFPSDAHKVAMMDKSPEIVKKIVVKIKV"
     gene            complement(11371..12081)
                     /locus_tag="RUMGNA_RS11885"
                     /old_locus_tag="RUMGNA_02701"
     CDS             complement(11371..12081)
                     /locus_tag="RUMGNA_RS11885"
                     /old_locus_tag="RUMGNA_02701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018593849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_023923965.1"
                     /translation="MISTDEGYMRLEYFSENVAADKKRKEFDIKNHALCYTNQKPDFLF
                     IGDSITEYWELNAYFGSGNHFLVNRGIAGDTTKYLKKRFYTDAVQLRPRYCILGIGIND
                     SIELEGDYWKRLEPTPYNQVVATAKLHITEIVQQAKEENICLILTSLLPIHIPILMDER
                     SRKNYIKELNEWLAEVAKKNNLIFVNYYATMVFPGTDKPLDKITYDGLHPNAKGYQIMA
                     TVLRNTLKKYEILI"
     gene            complement(12707..13429)
                     /locus_tag="RUMGNA_RS11890"
                     /old_locus_tag="RUMGNA_02702"
     CDS             complement(12707..13429)
                     /locus_tag="RUMGNA_RS11890"
                     /old_locus_tag="RUMGNA_02702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003445582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH1"
                     /protein_id="WP_004843644.1"
                     /translation="MPDDVIAAMDAEHRNYFYGDVHVRGKYPGYMKRYFREHGIQIQFA
                     PEDEEILKNTVDFVSFSYYMSVCATSDPEKQKKGLGNLLGGVPNPTLKASDWGWQIDPK
                     GLRYVLNMFYDRYQKPLFIVENGLGAVDVLVEDENGNKTVEDDYRIQYLKDHLIQVGEA
                     IQDGVEIMGYTSWGCIDVVSASTAELKKRYGYIYVDRNDDGTGTMERYKKKSFYWYQKV
                     IESNGEVLYSEEDINLSE"
     gene            complement(13414..>13429)
                     /locus_tag="RUMGNA_RS11895"
                     /old_locus_tag="RUMGNA_02703"
     CDS             complement(13414..>13429)
                     /locus_tag="RUMGNA_RS11895"
                     /old_locus_tag="RUMGNA_02703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009245098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="GH140"
                     /protein_id="WP_004843646.1"
                     /translation="MSRVTVSEDKSTFCRDKKPFFYLADTIWSAFTNITEDEWIYYLKR
                     RKEQGFNVLQINTMPQWDRCISDIGLYPFATADGHRFDFTKWNEAYYEHAVRMCELAEE
                     EGFQLALVVLWLNYVPGTWGSKVTDCNVMPKEFVKTYTEKIVHVFDRFEPIYIVSGDTD
                     FDTPEAVSYYRDALDVLCEKSPHTLKTMHIKRGYDFLPEEFLEKLDFYMFQSGHNREGQ
                     DMAYVLPENFRKKYPKKPLINAEPCYEQMGFRRKIYGRFQAEDTRKAAWSSILSGACAG
                     VTYGAHGIWNWQKLNKPVNPILGEGFDAPFPWNEALQFPGAWDYGMIRQLLDELHTGEL
                     IPAQEVLENETTQIRMAQTTDGRYLLYLPHSTKVVLKRELNGCSIRAMDLASGHRAYVS
                     AVCREGKTEIAMHPCQMM"
ORIGIN
        1 ttgacgatca aagaagtcag tgaaaaatat cagatcacac aggacaccct gcgctactat
       61 gaacgcatcg gtatgattcc ggcggttcct cgaacgtccg gtggtattcg taattacgga
      121 gaagcggatc tgggctggat tgaactcgcc ctgtgtatga gaaatgcagg tcttccagtc
      181 gaatccatga tcgaatacgt gcatctgttc caggaaggag acgagacgat ccccgcaaga
      241 ctccatctct tactggaaca gaaagaacat ctgatcgaac aacagaacaa gatttcgcaa
      301 atgttaaaac gcctggaata caagatcagt cggtatgaag aagcagtaca gaccggaaaa
      361 cttgtctgga atgaggataa agcggaggaa tgcaggaaac gataagagct tgtattagat
      421 aaaaattggg atacaaagat gatcatcaaa taagaaaaaa tcaacagctt acactttcct
      481 tatttggata tgtaagctgt tgacggttag tgcccaatga cattcctgta tctataattt
      541 tttgtttact ccacagaaat gataaaacgc tccaagtatt cctgcatcat tttggtgctt
      601 tgcgaatact attttagtac attcctcaat actggatata agatactttt tgacagaatt
      661 ttgaatttta cctcgcagaa actcttcctg ggccatgatg ccaccaccaa gcacaacaat
      721 ctctggattg atcacatagc aaatattggc aattcccttt ccaaggattt ctgccatttg
      781 atcaatggca cgattacaaa tcatatctcc ttttttggct tcctcgaaga tatggtatcc
      841 atcccactta tcttcagaat ctcctttcca ctgggatact tttttactta aaatgctggc
      901 tgccccaagc gtctgaaaat cactgccatc catgtgcata tacccaacct cacatgcact
      961 gttactaaaa ccatgaaata ccttcccatc taacacgata cagccaccaa tacccgtacc
     1021 tatggtcaac atcaaaacca ccctgcatcc tttcgctgca cctgaactat attctgcaag
     1081 ccctgcacag tttacatcat tttccacttc acatggtata tgaaatttat cctctaatgt
     1141 ctttttaaat tccatccccg catagtcagg aatcagtggt gctgaataaa aaatagaacc
     1201 gctttttgta tctaccattc ctgcagtaga aatgcagata cccgaaatct ttcccttggt
     1261 ttgttcaatc agatgctcca caatccctat aactttcttc agaattgcag gtccaccctt
     1321 ccacgcttct gttctcaaag tttctttcaa aataatttcc gcattttcac aaatgatgcc
     1381 atacttaatt gccgtccccc caatgtcaat acttatatac ttcttcattt cataccctca
     1441 tttactttct tatttaatcc catctgcatc ttaaatcaaa ctcttttcaa cctaaaaagc
     1501 aacacccggc ttttaagctg agccgggcat cactactaac aagtattcct acatggaatc
     1561 ttgtctacgt attatcatta tagaaatttc ttcttcgcat cacagatcat ctgtgcagct
     1621 tcttttacaa tctccatgtc ctcatctacc aatgctggaa gaggctctct tactgcacca
     1681 agttccagtc cttcattaat ctttagaatt gctttaataa ctgcatacat atttccatgc
     1741 gctgaacaca ttttgtaaat tatctcatta caagcatact ggatttttct tgcctctgtc
     1801 atctttcctg catttataca ctcatccaac tttaagtata attcaggcat agcaccatag
     1861 gttcccccaa ttgcaccctc tgccccgata acacgtccgc tcataaactg ctcatcagga
     1921 ccattaaaga taatgtactc agctcctgca gcctgcttaa acatttggat atcctgtacc
     1981 ggcatagagg aattcttgac accaatgacg ttgggatttt tcctcatctc tacaaataaa
     2041 ttctgtgtaa gtgcaacacc agcaagctga ggtatgttat aaattacaaa gtctgtgttc
     2101 ggtgccgctg cactaatggc attccaatac tgcgcaatag catattccgg taagtgaaaa
     2161 tagatgggag gaattgcagc gattgcatct acccccagcc cttctgcatg tctggcaagc
     2221 tcctgactgt ccttcgtgtt attgcaggcc acatgggcaa taactgtaag tttaccttcc
     2281 gctactttca taacattctc aagtacaatc ttacggtcct ccacactctg ataaatacat
     2341 tctccggaag aaccgtttac atagacacct tttacccctt tttttacaaa atattttgtc
     2401 agtccctgta caccttctgg actaatgttt ccttctttgt catagcaagc ataaaatgcc
     2461 ggaatcacac ctttatactt ctcaagattt ctcatagttt tgctcctttg cttcataaaa
     2521 gccattcatt ttgttttctc ccctagcgtt ccatttcctc tacaaatgat tttgtgatta
     2581 actgtggtct tgtgataatc gaaccaacta caacgctgta cgcaccaagt tcaatgacat
     2641 gccttgcctt ttggggtgta ttgatatttc cttcagcaat taccttgtgt ttgactcctg
     2701 caataatttc tctcagaatt tcaaaatcat tcttctctat tttatctccc ttactctgct
     2761 ccgtataacc gactagagtg gttccaataa aatcaaagcc aagatcatct gcatgaaggg
     2821 cttcttctat ggtagaacag tccgccatcc aaagctgatt aggatatttt tctttcactt
     2881 cgtggaagaa ttcatccaaa gtctgattgc tcggacgttt ggatatggtt gcatccattg
     2941 caataatatc cggtttcact tccatcaatt cttctatttc cttcattgtt ggagtaatat
     3001 aaactgcact gtcttcataa tccctcttta caataccaat gattggaaga tccacttttg
     3061 accgaatctc tttaatatct tcttttgaat tcgcacggat tcctctcgct ccgccttcct
     3121 ttgctgccag tgccattctt cccatgataa aagaagaatg tagtggttca ttcggcaatg
     3181 cctggcatga tacaatcaat ttccccttca gatttgccac tttctgatac atctcttttt
     3241 cctccttgga tttaacttcc gtatcattca tttcctcttt atgaaaataa gcggtcacgg
     3301 tatataccgc ctattttctt taattatcag gaatattaca tcttatggtt gaactttcag
     3361 ttcatcaata ttaaacctct catatttcaa tatatttttc agatgcaatt catttcttga
     3421 ccaggaatca tatttttcat ataaaagccc gatctcgcca tccggaagct ctgtcagaca
     3481 ggaataagag tagcccattt gaggggtatc cacagaatag caatatttcc aatctacaga
     3541 atacttatct tttccggaat ttcctgtttc gctgatcaaa ccaatccata tctttccatt
     3601 ttttctgcca ttggtcgcat ttggtgctga tagtaagata gcaggctttc catcaacagg
     3661 ctgtgaataa ttaatcactg acaactgcgt tccataccct gttgttgcaa tttctgttag
     3721 tggaactcgc tcactccagg tttctcctcc atctgtactc atcacttgtg caatatatcc
     3781 tgatcctgta cgcagataag ttttcaagga accatccggc atttctacga tctgtgcttc
     3841 tgcggttgcc ccacctgtat tctggtctgc ttctacgtat gtccagttat ttccatggtc
     3901 atcactatac ataaatccca gttctgcaga tgatttcgaa tacaatggaa caatcaatct
     3961 tccggcatgt tctccatttg ctatctgttt gcctacacct ggtcccaata cgagaaattt
     4021 tgattcctct ggcttaaagg tacttacaat ctgtaaatca gaccaggttt ctccctcatc
     4081 atctgagtat ttcattgcca aataagttgt tgggaatact ttaaaatctg catctttata
     4141 aaaaacattc atatttacgt ccgtgtccgt ctgtgtttcc aacaactttg taccttcaaa
     4201 attgtaatca tactgtttac atagcatggc atttccattt ttgtacagat tatattcacc
     4261 atcaacacta tattcagttg ctgaatttgt agtatcgtta taaatggttc cattttctct
     4321 tacagagtaa tcatacgttc ctgccgcatc atccttccag tgcaatttca aatatttctt
     4381 cccatcaacc tctttaaatc cagaacctac ggaagcgttg gaacttccaa ttcctgccgg
     4441 catcatatca gcaaaaagaa atacccgatg tgtttcctta tcctctaaaa gtaccggatc
     4501 tatgtaggaa gcactccctt gtatctgcac attcttgccc accgaatccc gtggccagtc
     4561 tatgttcttt gctacataat cgtcaaactt caatggcaat gtcggctgtc cccacgtttt
     4621 tccaccatct gtacttttcg caaatgctgt attgatctta ctttttgcat catgggtgcc
     4681 accatatctt gcatctgctg ctgcaatcac tgtaccagaa tccaacgcca aaagggatgg
     4741 gattcggaaa tagttggatt ttgtagcatc tcctgcataa aagatattct ctgcatatat
     4801 agtctttcct gtcacagcaa taagttcatc atcagaaagt acatcccgat atacctgcat
     4861 tctctctatg gaacctccaa atggataggc aacggttccc tgacgcatgg taccgcccag
     4921 cattacattg tctactcctg taatatcact gataaactta aatgcctcct gatccagcgt
     4981 tgctattaat tcgccatttg caaatagctt gtactgttta ttttctttgt ccgcttttaa
     5041 tgcaactgtg ttggatactc tttccccctt ataactacca cgcacagcag ccgggcaatc
     5101 cagcgtatat ttaaactcgc catctgtatt tctcaattcc atacctacgc cgcctgcatt
     5161 tgtgatatat aagtggaaat gtctatcctg atttcctttt gtaccatttc ccacactcaa
     5221 taacgattga atcgcatttt cactggttgt tttataggag ataacgatag ttccctgttc
     5281 caatgctttt actgttgctg ccccaggttc tttactcaaa tcatatcctg taccttccga
     5341 gatttcgatt ccttcctttt gcaacactgg taccgaagaa gattctgtat cttgtttctt
     5401 ctctgctaca gcctcaatca catctgtctg ggcctcttgg gcatatacac tcattggtgc
     5461 aacacacatc actgcagttg ctgctataga aacaattttt ttatacttat tcatatcgta
     5521 cttccctctc cgataatctc actgagtttc acttttcgat cttcgaacct tgatttcgtg
     5581 caggcatctg ccgtcgcaat cgcagctctt gcagcttctc ctgtgagcaa tggtctgaat
     5641 tcatcgtcaa cttcctttcc atggagaatg ccatttaggt atttcatctc atttttcata
     5701 atgctgtgga gccacattgg cggtttcttt cctggctttc catacataat ggcaccatcc
     5761 atctccgtac catgatagat tcttgtccga tcatcatctt cttcctgtga ctcatgcaca
     5821 aggaaatgtt cctccctgcc atctactttc agtgtaccgc cacaatcaca catatcaatc
     5881 ttaattgcac cttttgttcc ttgaatcagg acgtaatgtt ctggccaatg gaaagcagac
     5941 ccccattcta atactgcata ccgattatca gaaaactgca tattcacaaa caacatgtca
     6001 tcttcatctc caaaagcctc tccctgatgt gcaacatttc cacctgtcat ggtaacttct
     6061 tctggcattc ctcccatcaa aaactgtaca caatccaatt catggatgtg atggtacaga
     6121 tgtccacctg atttttccct gatttttttc caggaaatag ttggctgctg ttcttcccat
     6181 ccatttcttg cagaatggca atagagaact tttccaatca ccccatcatt aatcagtttt
     6241 ttcgcatagc gtaccccatg gaagaaattc ataacatgac ctgccataaa gattacaccg
     6301 tgttcctgac aggttcttac catttcgtca caatcctgat aggaaagtgc aatgggtttt
     6361 tcacaaaata cattcacgcc atgttctgct gctttgatga ccggctcttt atgtaagtaa
     6421 ttaggtgtgg caacaataac tgcttcaaca tcttccctgc tatatagagt atccagatcc
     6481 gtttccacat cacaatccaa ctcctctgct atggtctgac cgttttccgg atcaaggact
     6541 gccacaatcc tagcaccctc ctgttccttc ataattcttc caagttctgc accaaaatat
     6601 cctgttccta caattgcata tcctactgtt ttcattactt aatacctcca atttttttat
     6661 tttactgcac catctgtcat tccacctgca attttattct gaataaacat aaaaaatata
     6721 acggatggaa ctactacgag agttgatgct gccatcatat ctccccagtt caatatttca
     6781 gctccctgca aagattttaa tgccacggaa accgtcattt tatctgtact gttaattaaa
     6841 atcaatgaat ataagaattc attccatgca ttgataaatg tataaattgc tgttgctaca
     6901 atccccggca tgaccagagg aagaacaatc tgtacaaacg tttgaaattt attggcacca
     6961 tccactcttg ctgcttcttc aatccccaat ggcaccgttt tgaaaaatcc taccagcatc
     7021 cagactgcgt aaggaacact aaaggatagg tatacaataa tcagaccgat ccgggtatta
     7081 actaatccca actttgccat taccatagaa tagggaattg ccagcagaat gggtggaaac
     7141 atgtatgtag ctacaagtac ttttgacata atggaaccca gttttggaaa aaaacgtaca
     7201 atcccataag ccgccatgga agaaatcaca attgcaatgc acgttgtgat aatggctatg
     7261 aacaaactgt ttccaatatt tttagcaaat cccaaatcct gaatcacatg ggtaaagtta
     7321 tctaaggtaa aatgtttcgg taagaatctg gtaggattgg atgtcaattc tcccgatgcc
     7381 ttcaccgaac acaacagtat ccacactaac gggaaaaacg caatcaatga taagattatc
     7441 aaatataaat ggcagaaagc atttccgact tttccttttc gattcatcat catttatcct
     7501 ccttttccca ttttgcaata attgtaaagt acactacaca taccaacagc aaaaatgcca
     7561 gcaataacat ggtgactgca gaggatcttc ctaacagttt tgtattccaa cccatgttgt
     7621 aagcataaat cggcattgtt gttgttgcat ttgccggtcc accaccggta agcaggtaaa
     7681 taatatcaaa gttattgaat acccagattg tacgaagaac aactaaaagt ccaacaacaa
     7741 tcttaatatg cggtactgta atgaaccaaa actgctgaaa cttagatgca ccatcaatct
     7801 gtgccgcttc atactgatcc tgcggaattg tctgcaaagc agataataca ttcaccatga
     7861 tcatcggtgc accaaaccat acattgataa aaattaacgt caggaatacc agactgctgt
     7921 cactaaggaa ttgtggtaat tcgctgcata ttccaagctg aaccagcata ttgggaataa
     7981 atccagacac tccatttaaa atccatttcc aggacaatgc tattacaatg gatggaaatg
     8041 cccacggaat aatcatcaac gtacgataaa taccttttcc tacttttaca cggttaattg
     8101 caagagctgc tgtaaatcca ataaataact gccctaataa tgagcctata gtccataaaa
     8161 tagaatttag gaatgcctta taaaaatttg gatctgtcaa cacttcctta taattcgcca
     8221 ttcctataaa atcataggtc agccgaatca agtgctttga tgtcatgcta taatacaggc
     8281 tggaaaatat tgggtatatc agcaaaacac ctaccaccag caacgcaggt agtacaaaaa
     8341 tccaacgggc ataatctact ttttcttttc ttttcatcat atatgccttt cctcatttcc
     8401 tgggctatct atctaacccg ttttttcatt gctgcacggt actgaataat tcatttaatt
     8461 gcttttctgc tgttttggca gccttcttca catccgtacc attcgtaata atatcctgga
     8521 acatactttc aatgattccc tgagaagtaa ggaaacctgc ctgaatgctt ggaccatgct
     8581 catatccgat agcggttccc ttctccattg catctgtaat cacatcgact gcgttggaga
     8641 acttttgaac tgtctcgttt tccttatatt ccggcgtatc agaaattcca ctaatggaag
     8701 gaagcattcc tactggagtc gcatccagga atttaatata ggtatctctc tcatacagtt
     8761 ttttcataaa ggctttacag atttccggat gttttgaatt tctccaaatg accataggaa
     8821 tattagaagt ctcagctcca taatctggat catctgcatt cagctttgga agtggcgcac
     8881 aatcgatctg atcgatcaaa tccggagagt tggtttccac cccgctaatc tggaaacccg
     8941 aattaaaatc aaatgctgtt tttccctgat aaaacaaatt tgcctgatcc aatacagcat
     9001 aattgacaga atctttcgga gaacagtttt tataaatatc caaccagtat ttgattccat
     9061 ctattgccag gtcactggtc agatctgctt taaggtcatc ggtcaaaaga ctccctcccc
     9121 cactcctgac ataaaaattc aaaaacctgg ttgccataag atcatttgaa ccacaaggga
     9181 aggaacagcc atacacacca tcttttgtaa gtgtttttgc agcctcagca aattcatccc
     9241 atgtcttagg cacagaaagt cctgcttcct ccaataaatc cttacgatac cacataacct
     9301 gtgcgtgaga atacagtggc aaggaataac attccccatc tttttcacct tccgataatg
     9361 ccgtctttga aaatttgtcc cttccaatat catctattaa gtcatccaca ggcaccaaag
     9421 catctgcatt catcatctct accacatgcc ctggaagtgc agtactcatg tctggcacat
     9481 ttcctgaagc cagccccgtt gtccattttg tgtaaaaatc tccccaagag aatgtttcaa
     9541 ttttaatatt tactcccgga ttatctttca taaactggtc cgcggtttcc tgtatcactt
     9601 ccagtcttgg tccttgtgta aaagaatgcc aaaatgtaat atctcctttc agctcctcgg
     9661 atgccacttg atttgctgcg ccctcttctt tagaaccaca tcccgcaagt atggtagatg
     9721 caatcattgt tccggctaat aaaatagctg tttttttctt cataatctta ccctcatttg
     9781 ttcgttatgt tgttatttag tttcattttc ccaatgcagc cacatcattt gttttattgt
     9841 aatcttattt tagtcactat ttttatacat atctactaaa cgcacactca ataatagcat
     9901 tttacactca ttttttactc tcttgctact ttccgatatt gattcggagt aaaaccaaag
     9961 gctgacttaa attcccttat aaaataattc gtgtcttcat atccacatgc atacgcaata
    10021 tcattgatat tgtcattact taccagtaaa gcccttgctg ctgttgtaag ccgaatctct
    10081 ctcacatatt ccattggtgt ctttcccata ttaatcttaa ataggctgct gaatctctgt
    10141 ttactaagat ctgccatttc tgccatcttt tgtggcgtgt acttttcact tggatgcaga
    10201 ataatataat ctgccactat atagatcctt ggatcgattt gctcattctt ctttgaattc
    10261 ctatccctta atgacttttc ctctattgtt tccacgaaat ctccagtcac cttatcaacc
    10321 ttattcccgt gcatagccag cgaaccaatc agaagatcca aattccctct tacaaagcat
    10381 ttttttacca tggaatcctt ttttacccac ttataaattt ctttaaagta aacatcttct
    10441 ccctcattga ccgaaactct tggaatccca taatattccg ccaacatgtc ttccccttca
    10501 taaaataccg aggtagtaaa acgaagactg taaaactcaa aggattcacc gagcgcacga
    10561 caagacattt tgcatccctg cgggatatat acaatctgat tttcctccac aataatttct
    10621 tccccgtcaa tacaaagttc cgcctttcct ttttcaatat atcggaatat actatacgga
    10681 atcactgatt ccggatacac ccatgttctt cccatggaat aaaactcaat atataaaaac
    10741 gtaaatcgta tgttatctac cactgacata tcatcctcca ttgattaaaa aaacggctat
    10801 aatgacacac caagatttct ccctttcttt gaatattcct ttaaaacaga ttcaaagatc
    10861 ggaaaaacct aactatgtat tatagctgct ttcatcataa tttctttaaa ctttaatttt
    10921 aacgactatt ttttttacta tttccggtga tttatccatc attgcaacct tatgtgcatc
    10981 gcttggaaag cacaccataa actctcctgc cttcaataga taaccgcctg attcatcccc
    11041 ttgataaaac ccgatatctt tttcttcact gaacggcgtt tggatttgca gactacttac
    11101 atcagcagtt gcaattcttt ccactccttc aataatataa tgaacatcta tatacttttg
    11161 atgtgcttca tacatacact ccttttcttc cttgctaaca aatgatactg ggttcgccac
    11221 tatgactcct ttctgaatta cggtatccgg aaatgcttct tcccatcttt ttatttctgc
    11281 caaatagcat aatgcctgat agattttcct gtcttcctta tagttttcct tattctgaat
    11341 cgaatcaaat atcatctctg gtatctcctt tcaaattaga atctcatatt tttttaacgt
    11401 attacgtaaa actgtggcca tgatctggta tcctttggca tttgggtgca gaccatcata
    11461 ggtaatctta tccaacggct tgtctgttcc tggaaatacc attgtagcat aataatttac
    11521 aaaaataaga ttattcttct tcgccacttc tgccagccac tcattcagct ctttgatata
    11581 attttttcta ctcctttcat ccatcaggat cggaatatga attggtaaaa gagatgttag
    11641 aatcaagcag atattttctt cttttgcctg ttgtacaatt tctgtaatat gcagctttgc
    11701 agttgccact acttgattat acggtgtcgg ctccaatctt ttccaataat ccccttccag
    11761 ctctatggaa tcattaattc ctattcccag gatacaatat cttggacgta attgaactgc
    11821 atctgtataa aatcgctttt ttaagtactt tgttgtatct cccgcaatgc ccctattaac
    11881 aagaaagtga ttaccacttc caaaatatgc atttagctcc caatactctg taatggaatc
    11941 cccaataaag agaaaatctg gcttttggtt tgtgtagcat aatgcatgat tttttatatc
    12001 gaactctttt ctttttttat ccgctgcaac attttcagag aaatattcca gcctcatgta
    12061 tccttcatct gttgaaatca tctgttgcct ccttttgatt actataaata tgcgtttgca
    12121 aaacaccaca aaccgcatag atacagcctt ttttgttaca aaataaaata tctcctcaaa
    12181 actcatttgc aaagtaagat tcctaccata aaatttgtat gtcctatctt cctgatgatt
    12241 tattgctcgc tgacattaca taacttatta ccgcaatagt tgctaataaa attcatcaat
    12301 ataagtatcc gtagcctgaa acctctgatt gtctgacaac gtaggactct atctacattt
    12361 ccatcaggat tgcaaacgtg tttctcaatt acctatatta taaaaaataa gtgcatattc
    12421 cgaaactgaa tatgcactca aaaatagtat tatacgctta tttcatttcc tttttcacat
    12481 aaagaaggta tgacattctc tgaaactcta cctgtgtgtt tatatcttca ttagagaatt
    12541 atttcattgt ccatagctat gtaatcaata acctgacaga ttctaacacg ctgatcctgg
    12601 ttttaaaaca gatgtttgaa aatgagtact attgtatctt ccctgatggg aaaaaattgc
    12661 acccactcat acggaaacgc gagaaccgtc attctcccac acaatactat tcacttaaat
    12721 ttatatcttc ttcactatat agcacttccc cgttgctttc aatcactttc tgataccagt
    12781 aaaatgattt cttcttatac cgttccatcg tacctgttcc atcatcattt ctgtctacat
    12841 aaatgtaccc atatcgtttt tttaattctg cagtagatgc actgacaaca tcgatacatc
    12901 cccaggatgt gtatcccata atttccacgc catcctgaat cgcttccccc acctgtatca
    12961 ggtgatcctt cagatactga atccggtaat catcctctac tgttttgttt ccattctcat
    13021 cttcgaccag aacatctaca gctcccaatc cattttctac aatgaacagc ggcttctgat
    13081 agcgatcata aaacatattc agcacatagc gcaatccttt cggatcgatc tgccaccccc
    13141 agtcacttgc tttgagtgtt ggattcggta ctcctcccag aagatttcca agaccttttt
    13201 tctgtttttc aggatctgat gtcgcacaga cactcatata ataactaaat gatacaaaat
    13261 ctaccgtatt tttcagaatt tcttcatctt ccggagcaaa ctgaatctgg attccatgct
    13321 ccctgaagta tcgtttcata tatcccggat attttcctcg tacatgcaca tctccataaa
    13381 aatagttacg atgctctgca tccatcgccg cgatcacatc atctggcat
//
