LOCUS       NC_003098              13751 bp    DNA     linear   CON 22-MAR-2020
DEFINITION  Streptococcus pneumoniae R6, complete sequence.
ACCESSION   NC_003098 REGION: 285103..298853
VERSION     NC_003098.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN02603218
            Assembly: GCF_000007045.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae R6
  ORGANISM  Streptococcus pneumoniae R6
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13751)
  AUTHORS   Hoskins,J., Alborn,W.E. Jr., Arnold,J., Blaszczak,L.C., Burgett,S.,
            DeHoff,B.S., Estrem,S.T., Fritz,L., Fu,D.J., Fuller,W.,
            Geringer,C., Gilmour,R., Glass,J.S., Khoja,H., Kraft,A.R.,
            Lagace,R.E., LeBlanc,D.J., Lee,L.N., Lefkowitz,E.J., Lu,J.,
            Matsushima,P., McAhren,S.M., McHenney,M., McLeaster,K., Mundy,C.W.,
            Nicas,T.I., Norris,F.H., O'Gara,M., Peery,R.B., Robertson,G.T.,
            Rockey,P., Sun,P.M., Winkler,M.E., Yang,Y., Young-Bellido,M.,
            Zhao,G., Zook,C.A., Baltz,R.H., Jaskunas,S.R., Rosteck,P.R. Jr.,
            Skatrud,P.L. and Glass,J.I.
  TITLE     Genome of the bacterium Streptococcus pneumoniae strain R6
  JOURNAL   J. Bacteriol. 183 (19), 5709-5717 (2001)
   PUBMED   11544234
REFERENCE   2  (bases 1 to 13751)
  AUTHORS   Hoskins,J.A., Alborn,W. Jr., Arnold,J., Blaszczak,L., Burgett,S.,
            DeHoff,B.S., Estrem,S., Fritz,L., Fu,D.-J., Fuller,W., Geringer,C.,
            Gilmour,R., Glass,J.S., Hann,A., Khoja,H., Kraft,A., LaGace,R.,
            LeBlanc,D.J., Lee,L.N., Lefkowitz,E.J., Lu,J., Matsushima,P.,
            McAhren,S., McHenney,M., McLeaster,K., Mundy,C., Nicas,T.I.,
            Norris,F.H., O'Gara,M., Peery,R., Robertson,G.T., Rockey,P.,
            Sun,P.-M., Winkler,M.E., Yang,Y., Young-Bellido,M., Zhao,G.,
            Zook,C., Baltz,R.H., Jaskunas,S.Richard., Rosteck,P.R. Jr.,
            Skatrud,P.L. and Glass,J.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUL-2001) Infectious Diseases Research, Eli Lilly and
            Company, Lilly Research Labs, Indianapolis, IN 46285-0438, USA
COMMENT     REFSEQ INFORMATION: The reference sequence was derived from
            AE007317.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/22/2020 05:22:12
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Genes (total)                     :: 2,088
            CDSs (total)                      :: 2,015
            Genes (coding)                    :: 1,862
            CDSs (with protein)               :: 1,862
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 153
            CDSs (without protein)            :: 153
            Pseudo Genes (ambiguous residues) :: 0 of 153
            Pseudo Genes (frameshifted)       :: 72 of 153
            Pseudo Genes (incomplete)         :: 69 of 153
            Pseudo Genes (internal stop)      :: 49 of 153
            Pseudo Genes (multiple problems)  :: 32 of 153
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..13751
                     /organism="Streptococcus pneumoniae R6"
                     /mol_type="genomic DNA"
                     /strain="R6"
                     /db_xref="taxon:171101"
     gene            34..3237
                     /locus_tag="SPR_RS01490"
                     /old_locus_tag="spr0286"
     CDS             34..3237
                     /locus_tag="SPR_RS01490"
                     /old_locus_tag="spr0286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBM70|PL8_1|PL8q"
                     /protein_id="WP_001193721.1"
                     /translation="MQTKTKKLIVSLSSLVLSGFLLNHYMTVGAEETTTNTIQQSQKE
                     VQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQGWSAWVDQKNSSADASTRVIEAKDG
                     AITISSPEKLRAAVHRMVPIEAKKKYKLRFKIKTDNKVGIAKVRIIEESGKDKRLWNS
                     ATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQPSEDSQT
                     DKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKE
                     VKKIPLKILASVKDTYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSI
                     SSQADRIYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSME
                     WMHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDP
                     EHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGF
                     YQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAP
                     LLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQ
                     SDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGF
                     GLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTE
                     TDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFL
                     GSNIQNTSTDTAATTIDQRKLESSNPYKVYVNDKEASLTEQEKDYPETQSVFLESSDS
                     KKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYM
                     LIPNVDRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVL
                     KRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKN
                     HSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN"
     gene            complement(4381..5010)
                     /locus_tag="SPR_RS01505"
                     /old_locus_tag="spr0287"
     CDS             complement(4381..5010)
                     /locus_tag="SPR_RS01505"
                     /old_locus_tag="spr0287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="WP_000167287.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKELVDLYQDDQSVCIGAGTVLDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSALSPAYISAVKAPIPQVSVMV
                     TGGVDLNNIPQWFAAGADAVGIGGELNKLASQGNFDRISEIAQQYVTLR"
     gene            complement(5020..6021)
                     /locus_tag="SPR_RS01510"
                     /old_locus_tag="spr0288"
     CDS             complement(5020..6021)
                     /locus_tag="SPR_RS01510"
                     /old_locus_tag="spr0288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="STP|PfkB"
                     /protein_id="WP_000161491.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYYLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMDSLFQGISHFHFSGITVAIGQEVRAILLLLLKEAKRRGI
                     VVSMDLNLRTKMISVLEAKYEFSKFARFTDYCFGIDPLMIDDQNLEMFPRDSASLEEV
                     ENRMRLLKEAYGFKAIFHTLRSSDEQDKNVYQAYALEERFEESVQLKTAVYQRIGSGD
                     AFISGALYQLLHHSSLKTTIDFAVASATLKCTLPGDHLSTSATSIENLLANAQDIIR"
     gene            complement(6052..6693)
                     /locus_tag="SPR_RS01515"
                     /old_locus_tag="spr0289"
     CDS             complement(6052..6693)
                     /locus_tag="SPR_RS01515"
                     /old_locus_tag="spr0289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="WP_000684777.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKDYQLFNYGMRGEEGE
                     SQLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFERLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITHNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            complement(6712..7527)
                     /locus_tag="SPR_RS01520"
                     /old_locus_tag="spr0290"
     CDS             complement(6712..7527)
                     /locus_tag="SPR_RS01520"
                     /old_locus_tag="spr0290"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="WP_000185874.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE"
     gene            7798..8232
                     /locus_tag="SPR_RS01525"
                     /old_locus_tag="spr0291"
     CDS             7798..8232
                     /locus_tag="SPR_RS01525"
                     /old_locus_tag="spr0291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DR78|4.A.6.1.14"
                     /protein_id="WP_000706826.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGSPFKVSSTIMGENPAKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEEEDFESGI"
     gene            8244..9434
                     /locus_tag="SPR_RS01530"
                     /old_locus_tag="spr0292"
     CDS             8244..9434
                     /locus_tag="SPR_RS01530"
                     /old_locus_tag="spr0292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH88"
                     /protein_id="WP_000592948.1"
                     /translation="MIKKVTIEKIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDR
                     VNKRVELDHHDLGFLYTPSCMAEYKINGDGEAREATLKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            9445..9936
                     /locus_tag="SPR_RS01535"
                     /old_locus_tag="spr0293"
     CDS             9445..9936
                     /locus_tag="SPR_RS01535"
                     /old_locus_tag="spr0293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003035570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DR76|4.A.6.1.14"
                     /protein_id="WP_000178620.1"
                     /translation="MTMPNIIMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKDVKDALTLVEGGVPIKE
                     INIGNIHNAPGKEQVTRSIFLGEEDKAALKELSQTHQVTFNTKTTPTGNDGAVQVNIM
                     DYI"
     gene            9951..10730
                     /locus_tag="SPR_RS01540"
                     /old_locus_tag="spr0294"
     CDS             9951..10730
                     /locus_tag="SPR_RS01540"
                     /old_locus_tag="spr0294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DR75|4.A.6.1.14"
                     /protein_id="WP_000026610.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTADHVVEEEAHDDWI"
     gene            10717..11535
                     /locus_tag="SPR_RS01545"
                     /old_locus_tag="spr0295"
     CDS             10717..11535
                     /locus_tag="SPR_RS01545"
                     /old_locus_tag="spr0295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gnl|TC-DB|Q8DR74|4.A.6.1.14"
                     /protein_id="WP_000148019.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEGFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPTKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVVGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKIIA"
     gene            11535..11828
                     /locus_tag="SPR_RS01550"
                     /old_locus_tag="spr0296"
     CDS             11535..11828
                     /locus_tag="SPR_RS01550"
                     /old_locus_tag="spr0296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_000381739.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRQEYLA
                     SLTSGDEVLLLSGIHGKIISIQDDLVSLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            11850..13751
                     /locus_tag="SPR_RS01555"
                     /old_locus_tag="spr0297"
     CDS             11850..13751
                     /locus_tag="SPR_RS01555"
                     /old_locus_tag="spr0297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PL12_1"
                     /protein_id="WP_000657079.1"
                     /translation="MKEERRQFFERVDGNQCRDYILSHCSKDYEKVKSSLERLIDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWSYMLqqNRQEYLLQFMIGYLVEGDKGYI
                     QKCKFFLFDWIEQVREFSPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEKELEKIL
                     VSLEKQIDFMKSYYRAKYTLSNWGILQTIPMLAIYHFFSDKMDLEEAYHFASEELKQQ
                     IETQILGDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSYQELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEMLSLSAVVLNKEDLLNGLDVKVDLLSILFLGREKVKRLQEFE
                     RRAWQPKSMIFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREIYERYLLKSAWSHSTCIVDGKAPERITGSWEYEYYPHSLFCHHKEREGMHY
                     IEGAYWSAEPDLPYLHKRKILMLVEDVWLLVDDIRCQGQHEALTQFILDKDVTYQDGK
                     INQLRLWSEVDFDLEDTIISPKYNELERSSKLTKRQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDDREVENALAFEVKNDETDKLILLLSEDIRVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
ORIGIN      
        1 ttgattttac aatatgttta ttggagtgta tacatgcaaa caaaaacaaa gaagctcatt
       61 gtgagtttgt cttcacttgt tttatcagga tttttattaa accattatat gacagttgga
      121 gcggaagaaa cgactacgaa taccattcag caaagccaga aggaagttca gtatcagcaa
      181 agggatacaa aaaatttagt tgaaaatggt gattttggtc agacggagga cggaagcagt
      241 ccgtggacag gaagcaaagc tcaggggtgg tcagcttggg tagaccagaa gaatagttct
      301 gcagatgcct caactcgagt cattgaggct aaggatgggg ctatcactat ctcaagccct
      361 gagaaattaa gggcagcggt tcaccgtatg gttcctattg aagctaagaa aaagtataaa
      421 ctgcgtttca agattaaaac agataataaa gtcgggattg ccaaagttcg tatcattgag
      481 gaaagtggta aggacaagcg attgtggaat tctgcaacga cgtcaggaac aaaggactgg
      541 cagaccattg aagcagacta tagcccgact ttagatgttg ataaaatcaa gctggagtta
      601 ttctatgaaa caggaactgg gactgtttcc tttaaggata ttgagctggt agaggtagca
      661 gaccagcctt ctgaggattc tcaaacagat aaacaacttg aggaaaagat tgatttacca
      721 attggaaaaa aacatgtttt ttctcttgcg gactatactt ataaggtaga aaatcctgac
      781 gttgcttcag tcaaaaatgg aattttagaa cctcttaagg aagggacaac caatgtcatt
      841 gtcagtaaag atggcaagga agtgaaaaag attcctttga agattctagc ctctgttaag
      901 gatacataca cagaccgttt ggatgactgg aatggcatca tcgctgggaa tcaatactat
      961 gattctaaaa atgaacagat ggccaaatta aaccaggaat tggaaggaaa ggtagctgat
     1021 agcctatcca gtatttcaag tcaggcggac cgcatctatt tgtgggaaaa attttcaaat
     1081 tataaaacgt ctgcaaatct gactgccact tatcggaaat tggaggagat ggccaagcaa
     1141 gtgaccaatc cttcttctcg ttattatcaa gatgaaactg tcgttcgaac agtcagggat
     1201 tccatggaat ggatgcataa acatgtctac aatagtgaaa agagcattgt tgggaactgg
     1261 tgggattatg aaatcggtac acctcgtgcc atcaacaata ccttgtctct gatgaaagaa
     1321 tacttctctg atgaggaaat taaaaaatat acagatgtga ttgaaaaatt tgtaccagat
     1381 cccgaacatt tccgaaagac gactgataac ccattcaagg ctctaggtgg aaacttagtt
     1441 gatatgggaa gggtaaaagt aatagctggt ttactgcgta aggatgatca agaaatttct
     1501 tctaccattc gctcgattga gcaagtgttc aagttggtag accaaggtga aggtttttat
     1561 caagatggat cctatatcga ccacaccaat gttgcctata cgggtgctta tgggaatgtt
     1621 ttgattgatg gcctgtctca actgttgcca gtcattcaaa agaccaagaa tccaatcgat
     1681 aaagataaaa tgcaaaccat gtaccactgg attgataaat cgtttgctcc tttgctggtg
     1741 aatggagagc tgatggatat gagtcgtgga cgctcgatca gtcgtgcaaa tagcgagggg
     1801 cacgtggccg cagtagaagt actaagaggg attcaccgaa tagcggatat gtctgaagga
     1861 gaaaccaaac aacgtttgca gagtcttgtg aagaccattg ttcaatcgga tagttattat
     1921 gatgtcttta agaatttgaa gacttataag gatatcagtt tgatgcaatc cttgttaagt
     1981 gatgcaggag tcgcaagtgt tccaagaaca agttacctat ctgcctttaa caagatggat
     2041 aaaacagcca tgtacaatgc agagaaaggg tttggatttg gcttgtcact cttttccagt
     2101 cgtaccttga attacgaaca catgaacaag gaaaataaac gtggttggta tacgagtgat
     2161 gggatgttct atctttacaa tggcgatttg agtcactata gcgatggcta ctggccaaca
     2221 gttaatccat ataagatgcc tggtacaaca gagacggatg ctaagagagc ggatagcgat
     2281 acaggtaaag ttttaccgtc tgctttcgtt ggaacgagca aactagatga tgccaatgcg
     2341 acagcaacca tggatttcac caactggaat caaacattga ctgctcataa gagctggttt
     2401 atgctaaagg ataagattgc ctttttagga agcaatatcc aaaacacttc aacagatact
     2461 gctgcaacta caattgacca gagaaaactg gaatcaagta atccatataa agtctatgtc
     2521 aatgataaag aagcctccct tacagaacaa gaaaaggatt atcctgaaac ccaaagtgtc
     2581 tttttagaat cgtccgattc gaaaaagaat attggttact ttttctttaa gaagagttca
     2641 atcagtatga gtaaggcttt gcaaaaggga gcctggaagg atatcaatga aggacagtca
     2701 gacaaggaag ttgaaaatga atttcttacg attagtcagg ctcataagca aaatggagat
     2761 tcttatggct atatgctcat tcctaacgtg gatcgtgcca ccttcaatca aatgataaaa
     2821 gagttagaaa gtagcctcat cgaaaataac gaaacccttc agtctgttta tgatgccaaa
     2881 caaggagttt ggggcattgt gaaatatgat gattctgtct ctactatttc caaccaattc
     2941 caagttttga aacgtggagt ctatactatt cgaaaagaag gggatgaata taagattgcc
     3001 tactataatc ctgaaaccca ggaatcagct ccagatcagg aagtctttaa aaagctagag
     3061 caagcagctc agccacaagt acagaattca aaagaaaagg aaaaatctga agaggaaaag
     3121 aaccattcgg atcaaaagaa tctccctcag acaggagaag gtcagtcaat cttggcaagt
     3181 ctagggttct tgctacttgg ggcgttttat ttattccgta gaggaaagaa caactaattt
     3241 gttcatcatc tagatgaatt acatgaaact gtggaaaata gaaaaaatcc gaagaaggcc
     3301 aaatatcttc ggatttttct tttaaaaagg gataagttga tacttatcct tttttacttc
     3361 attatgtgac tatagcgttt tgaaactaga ataggacatc ataactgcta aaagatttct
     3421 ataaattcat ttgattttcc taatcaattt gttcgtatcc tatttcactc tactatatta
     3481 gtccgtctcg cacctcacgg agcgagacaa aacaaccacc cgctatgcgg gtgcgcgtcg
     3541 aaggttatac caaaaaaact ccaaacgcga tacaataaag gtgttcaatc cacttgtaaa
     3601 gcgaaaggag aaaaaatatg gcacaaaagg ctcatagttt atctcacaca aagtggaggt
     3661 gttctatcac attgtgttca cccctaagta tagacgaaaa gtcatctata atcaatatag
     3721 aagtagttta ggcgaaatat ttcatcgctt gtgtagttat aaaggtgttg aaatgatcga
     3781 gggtcactta atgccagacc atgtacacat gttagtcagt attccactaa ggctaagtgt
     3841 ttcgagtttc atggggtatt taaaaggcaa aagtgcactc atgatgtttg acaaacacgc
     3901 caatctcaag tacaagtttg ggaatcggca tttctgggtg gaaggttatt atgtaagtac
     3961 agtagggctt aataaagcta caattaagaa atatagtcaa gattaaagaa attatccagt
     4021 ggatgatttc ttcacgagta tgaaaatttg agaactagta aagcatgata tatagtaaaa
     4081 tgaaataaga acagaacaaa tcgatcagga cagtcaaatc gatttttaac aatgttttag
     4141 aagtagatgt gtactattcc agtttcaatc tactatagca ctagataaat tgagtgtaaa
     4201 agaatatgag gatcccttta gggatagtgg taagtaatac caaagtctct taaagaggca
     4261 agtgacgagt caagagcaat aaggcttgaa caacgtgaaa gccagcgtct ttaggcgctg
     4321 gctgatgatt tgggcttata gctctgggat aaaccacccg tttgacgggt ggttatgatt
     4381 ttatctgagt gtaacatact gttgggcaat ctcgctgatg cggtcaaagt tgccttggga
     4441 agcgagttta ttgagttcgc caccaattcc aacggcatct gcaccagcag cgaaccattg
     4501 agggatgttg tttaggtcga ctcctccggt taccattacg gaaacttgtg ggatcggtgc
     4561 cttgactgca gagatatatg ctggactgag agcactacct gggaagagtt tgatgatttc
     4621 actaccggct tcaagtgcag tcgtgatctc tgtgagggta atacagcctg gaatgtacgg
     4681 tgtgctgtag agattgcaca ttttcgcagt ttcagcatgg aaagatggag aaacaacgta
     4741 atttgctcca gctagaatgg catctctagc agttacggca tcaagcacag tacctgcacc
     4801 gatacaaaca ctctgatcgt cctgatacaa gtctacaagt tccttgatga tttgtcctgc
     4861 atactgattg gtataggcga tttcaatagc tttgataccg cccttgatac aagcaatcga
     4921 ggcttgtagt ccttcttcct ttgtatttcc tcgaatgaca gcgacaattt tctgtttttt
     4981 tagttcaata atcgtatctg atttggtcat gtaattctcc taacgaatga tatcttgtgc
     5041 atttgccagt aaattttcaa tactagttgc ggaagtggag agatggtctc ctggaagagt
     5101 gcatttgaga gttgcgctcg caactgcaaa gtcaatggta gtttttaggg aggaatgatg
     5161 gagtagttgg taaagggcac cagatataaa ggcatccccg ctaccaattc gttgatagac
     5221 tgcagttttt agttggacag actcttcaaa tcgttcttcc agagcatagg cttgatagac
     5281 atttttgtct tgctcatcac tagatcggag ggtatggaaa atggccttga aaccataggc
     5341 ttcttttaaa agtcgcatgc gattttccac ctcttctagg ctagcactgt ctcttggaaa
     5401 catctctaga ttttggtcat caatcatgag aggatcaata ccgaagcaat agtcagtaaa
     5461 acgtgcaaac ttagaaaatt catacttggc ttctaggact gaaatcatct ttgttctcag
     5521 attgagatcc attgaaacga caattcctcg gcgtttagct tctttcaaga gtaggagaag
     5581 gatcgcacgg acctcttgac cgatagctac ggtgattcca ctaaaatgaa aatggctaat
     5641 cccctgaaag agagaatcca tatctagcat gtttggccga atctggctga tactcgtatg
     5701 cttacgatcg tagaaaactt cactttgacg acaaccaaag ccgttctcca aatagtagag
     5761 gccgattcga tcgccaagcc gacagattga actggtatcg atttggtgct gtttcaagaa
     5821 tgtgagaaaa cgatctccaa tctcgttggc agggagtgcg gtaaagactt tcgttgagat
     5881 acccagagct tgcaaattac aagcgatgtt aatttctgat ccgccaaaat aagtcgaact
     5941 ggcaacatga tcgccgatac tggtggcatc taatggtgag attcgaatta atggttcgcc
     6001 aaacagtaat attttcgtca tccattagtt cctttctggt ttagaatagc tttacttggc
     6061 taatacttct ttcaaataag cagcgacttc atcatcttgg cagttttcaa agaagtattc
     6121 ttggaaatat ttgccagaga tggtgtcttt gaggaagtct tggtcgattg ttttaaggat
     6181 ggtcatcaaa tcattgtggg tgatttgttt cacctcgttt aagatacgag cgttgcgttg
     6241 ttcagggatt acacgttctc ttgggtagcc accgcccatt tcttcagcaa ataagcgttc
     6301 aaacatcaat ttgagggtca gttctgcccc ccagccaaat cctttggcat aagggataga
     6361 caaggcgtta ccaccattga tttgagaata aaggtaagcg tcagttgggt ccactgctag
     6421 accacagaca acaccaggga agctgtttaa agcaagcata gcccctacac ccgtaccaca
     6481 gccggtaaca acaaagtcaa ctgcctttgt atttaaaagg atggcagcca ttagtccgtt
     6541 ctgcacataa gttaattgac tttctccttc ttctccacgc ataccatagt taaataattg
     6601 gtagtctttt ttatctgtcg cttcttttag actatcgtaa ataatgtgat tcttgctagc
     6661 ttgactattt tcattgatta atgcgatttt cataagatct tctttctatt tttactcagg
     6721 ttgttttccg atgtaggcta agataccgcc atctacatat aggatgtggc cattgacaaa
     6781 attgctggca tcactagcga gaaagacagc agggcccatc aaatcttcag gatttcccca
     6841 acgtgcagca ggtgtttttg caatgatgaa ctggtcaaat gggtggcgag aaccatcttc
     6901 ttgcaactca cgaagaggtg ctgtttgagg agtggcaata taacctggtc caattccgtt
     6961 acattggata ttggctccac cgtattcaga cgcaatgttg cgggtcaaca ttttcaagcc
     7021 ccctttagca gcagcataag cgctaactgt ttcacgtccc agttcgctca tcatcgaaca
     7081 aatattgata atctttccat gccctttctt tatcatagaa ggaataactg cctttgaaac
     7141 gataaatggt gcgtttaagt caatatcgat gaccttacgg aaatcagcgg cgctcatttc
     7201 gcacattgga actcggcgga taataccagc gttattaacg aggatgtcaa tgacaccaac
     7261 ctcttgttcg atttgcttga ccatggcttg gataccgtcc tcgtctgtca cgtcacagac
     7321 atatccatgg gcttcgatgc caacttcacg ataagcttca atccctttat tgaccagatc
     7381 ttgattgata tcgttaaaga caatagtagc gccggcttca gcgtaggatt tggcaatagc
     7441 aaatccaatt ccataagaag cgccggtgat gagagcaatt tttcctttta aagaaaactg
     7501 ctcaattgag aatgatgtat ttgtcatttg atacttcctt tcaaatttgt taagacttct
     7561 ctataaccaa attatattct agtaaaccgg ttttgtcaat aaataaatat ttttatttat
     7621 aaaaagattt attttcctta aaaatggaat attttgaaat ttctgtctat taaaatgatt
     7681 aaaaagataa tgaaagcgct aatatttttt taaaaaaact attgacaaga taaaaataaa
     7741 ggattacaat ggggaatata aagtaaaccg gtaaacctaa acaagaaagg agaaaagatg
     7801 aaaattgtac ttgtagggca tggacatttt gctacaggga tttatagttc tttacaattg
     7861 attgcaggca atcaagaaaa tgtggaggca attgactttg tggaaggaat gtcagcagat
     7921 gaactcaagc aaaaaatctt acttgcaatt tcaaatgaag aagaagtttt aatcctaagt
     7981 gatctcttgg gaggatcgcc attcaaggtt tcttctacca taatgggaga aaatccagcc
     8041 aaaacaatga atgttctctc gggtttgaac ttagccatgt taatggaagc agtctttgct
     8101 agaatggctc atagctttga tgaggttgtt aataaatcag tagtggcggc ccagggcgga
     8161 gtcgtaaatg gtaaagaatt gttttcaacg gatgcagagg aagaggaaga agatttcgaa
     8221 tcgggtattt aaagggtaaa agaatgataa aaaaggttac gattgaaaaa ataaaatcgc
     8281 ctgagcgctt cttagaagta ccacttctga cgaaagaaga agtcggccag gcaatcgata
     8341 aggttattcg gcagttagaa ctcaaccttg actatttcaa ggaagatttc ccgacgccag
     8401 ctacctttga taatgtctat ccaatcatgg ataacacgga atggaccaat ggtttctgga
     8461 caggagaact gtggttggct tatgaataca gtcaacagga tgcatttaaa aacatcgctc
     8521 ataaaaatgt tctttctttc ctggatcgtg tcaataagag agtagaattg gatcaccatg
     8581 atctcggctt cttgtacaca ccgtcttgta tggctgaata taagataaat ggagatggag
     8641 aggctagaga agcaaccttg aaagctgcag ataagttgat tgaacgctat caagaaaaag
     8701 gtggttttat tcaagcttgg ggagacttgg gcaagaaaga gcattaccgt ttgattatcg
     8761 actgcttgct caatatccaa ctcttattct ttgcttatca agaaacaggc gatcaaaaat
     8821 actacgatat tgcagaaagc catttctatg cttcagctaa taatgtaatc cgtgatgacg
     8881 cttcgtcctt ccacaccttc tattttgatc ctgagacagg tcaacccttt aaaggtgtaa
     8941 cgagacaagg gtatagtgat gattcatgct gggcacgtgg tcaatcatgg ggagtctatg
     9001 gtattccttt gacttatcgt cacttaaaag acgagtcctg ctttgacttg tttaagggtg
     9061 tgaccaatta tttcttgaat cgtctgccaa aagatcatgt gtcctattgg gatttgattt
     9121 ttaatgatgg tagtgatcaa tcacgagatt cttcagcaac agctatcgcc gtctgtggga
     9181 ttcatgaaat gctaaaacat ctcccagagg tggatgctga caaagatatt tataaacatg
     9241 ctatgcatgc catgcttcgt tccttgatcg aacattatgc aaatgatcaa tttacccctg
     9301 gtgggacaag tctcctccac ggtgtatact catggcattc aggtaaagga gtggatgaag
     9361 gcaatatctg gggtgactac tattacctag aagcccttat ccgtttctac aaagactgga
     9421 acctatattg gtaggaggag aaatatgaca atgccaaata ttattatgac ccgtatcgat
     9481 gaacggttga ttcatggaca aggacaactt tgggtaaaat acctaggttg taatacggtc
     9541 attgttgcca atgacgaagt aagcacggac aagatgcaac aaactctgat gaaaacagtt
     9601 gtgccagact cagttgccat gcgtttcttc cctttgcaaa aggtgattga tatcattcac
     9661 aaggctaatc ctgctcaaac gatctttatc gttgtaaagg atgtaaagga cgctttaacc
     9721 ttggtagaag gtggtgtccc tatcaaagaa atcaatattg ggaacattca caatgcccct
     9781 ggtaaagagc aagtgacacg ctccatcttc ctgggtgaag aggacaaggc agccctcaag
     9841 gaattaagcc aaactcatca agtaacattt aatacgaaaa caactccaac aggaaatgat
     9901 ggagctgttc aagtcaacat tatggactat atttaaaaga ggagatcgtt atgtcgatta
     9961 atgtatttca agcgatttta attggattat ggacagcttt ctgttttagt ggaatgctgt
    10021 taggaattta caccaataga tgtattgttc tgtcatttgg tgtcggaatt attctaggtg
    10081 atctgcctac tgctcttgca atgggagcta ttggtgaatt ggcttatatg ggattcggtg
    10141 ttggtgctgg aggtactgtt ccaccaaacc caatcggacc tggtatcttt ggtaccttga
    10201 tggctatcac tagtgctggt aaagtcagtc cagaagcggc tcttgccctc tctactccga
    10261 ttgctgtggc gattcaattc ttacaaactt tcgcctacac tgtacgtgct ggtgcgcctg
    10321 aaacggcgat gaagcacttg aaaaaccata atttgaagaa atttaagttt actctaaatg
    10381 caacaatttg gttgtttgcc tttattggat ttaccttggg ttgcttgggt gccctttcaa
    10441 tggatacctt gttgaaactc gtagactaca ttccaccggt attgcttaca ggtttgacag
    10501 ttgctggtaa aatgctccca gctatcggtt ttgcgatgat cttgtcagtg atggctaaga
    10561 aagagttgat tccctttgtc ttgttgggat atgtttgtgc agcttatcta aacatcccaa
    10621 caattggtat tgcaattgta ggtactatct ttgctttgat tgaattttat aacaagccaa
    10681 aaacagcgga tcatgtggta gaggaggaag cacacgatga ctggatctaa caaattaaca
    10741 aaacgtgatt atcttaaaac gtctttgcgg gcattctttt gtcaaaatgg atttaactat
    10801 agtaactatc aagggttggg atatgccaat gtgatgtatc ctgctttgaa aaaacactat
    10861 ggagaggatc aggaaggttt ctaccaagcc ttggaagaaa actgtgaatt ttataatacc
    10921 aacccacact tcctgccttt tattaccagc ttgcatcttg taatgttgga aaatggccga
    10981 ccaacaaaag aaacacgtag catcaagatg gccttgatgg gaccattggc aggtattggg
    11041 gattctcttt ctcaattctg tttagctcca ttgttctcaa ccatcgcagc ttcgtttgct
    11101 caagaaggct tggttgtcgg tccaatcttg ttcttccttg cgatgaatac gattttaaca
    11161 gcgattaaat tgtcaactgg tctgtatgga tacaaactag gaacaactgt gattgataaa
    11221 ctaagcgaac agatggcaac gatttctcgt attgccaata ttatcggtgt aaccgtaatt
    11281 gctggtttgg cagcgacatc tgttaagatt atggtgccga ttacctttgc tgcaggggaa
    11341 gttaaagcag acgctaaaca aagtatcgta agtattcagg gaatgcttga taaggttgct
    11401 ccagctcttc taccagccct atttacactt ttagtttact acttgatcaa agaaaagaaa
    11461 tggacaacat ataaactcgt tattttaaca gttatcatcg gaattatcgg aagctggctt
    11521 aagattatag cttaatggat acaacattgt tttatggaat agtgattgtc ttggcagtga
    11581 gtcccctttt actgtcaagc tttcattcta ttcgtcagca aaagttgctt cgcaaacaga
    11641 tggagcaacg acaagagtat ttagcttctt taacatctgg tgatgaagtg ttgttattgt
    11701 ctggaattca tggaaaaatc atttctatcc aagatgactt ggtctccttg cagattgcaa
    11761 aaggtgtggt catctatgta gaaaaggaaa gtgtaatggg aaagacaaaa gaactgcttt
    11821 ttaagtagtt ctttttctgg taatagataa tgaaagaaga aagaagacaa ttttttgaaa
    11881 gagtcgatgg aaaccaatgt cgtgattata tcttgtccca ctgttcaaaa gactatgaga
    11941 aagtcaagag ttcccttgaa cgcttgatag acaatcgttt tatgtttgat agtccttggg
    12001 atatggagcc ttgttcaaaa atccatcaaa tccagccgat ggtatgggat caagtatttg
    12061 aagatgatcc agaatggtct tatatgctca atcgacaaga atatctcttg cagtttatga
    12121 tagggtatct ggtagaagga gataagggct atatccaaaa gtgcaagttc tttctatttg
    12181 attggattga gcaggtgaga gaattttctc ctcaatcctt gatgactaga accttggata
    12241 cgggtattcg ttcctttact tggttgaaac tactcttgct cctcttgaaa tttgacttgc
    12301 tagaggagaa agaactagag aaaattttgg tcagtctaga aaagcagatt gactttatga
    12361 aaagctacta tcgcgccaag tacaccctta gtaactgggg gattttacaa acaattccga
    12421 tgcttgctat ctatcatttc ttttcagata agatggatct agaagaagct taccattttg
    12481 cttcagagga gttgaaacag caaattgaga cacagatttt aggagatgga agccagtttg
    12541 aacagtcgat tctctatcat gtagaggttt ataaagcctt gctggatttg tgtctcttgc
    12601 ttccagactt gcaagatagt taccaagagt tgctggaaaa gatggcgacc tatattcaaa
    12661 tgatgacagg cttagatgga cggactttgg cttttggtga tagcgattct acagaaacga
    12721 cagaaatgtt gagcctgtct gctgtggttt tgaacaagga agaccttctt aacggtctgg
    12781 atgttaaagt tgatttgctt agcatcttgt tcctggggcg agaaaaggtc aagcgactgc
    12841 aggaatttga aaggagagct tggcagccta agtccatgat ctttgaagac tctggacatg
    12901 tctgcattaa ggatgaacat cgttatctat ttttcaaaaa tggtccgcta ggaagtgccc
    12961 atagccatag tgacgagaat agtttttgct tacagtatca aggccaacct attttcatag
    13021 atgctgggcg ttattcttat cgggagatat atgaacgtta tctcttaaag agtgcttgga
    13081 gtcattcgac ctgcattgta gatgggaaag ctccggaaag aatcacggga tcctgggaat
    13141 atgaatacta tcctcactcc ctgttttgtc accataaaga aagggaggga atgcattata
    13201 ttgaaggggc ttattggtca gcagaacctg atttgcctta tcttcacaag agaaaaatcc
    13261 tcatgttggt agaggatgtc tggctcttgg tagatgacat caggtgtcaa ggtcagcatg
    13321 aggcgttgac tcagtttatc cttgacaagg atgtgaccta tcaagatggg aaaatcaatc
    13381 agttgagact atggagtgaa gttgattttg atttggaaga taccatcatt tctcctaaat
    13441 acaatgagct tgaaagaagt agcaaactca ccaagcgcca attctttgag aatcagatgc
    13501 tggattatac catcattgcg catgagagtt ttgaaatcat ccgtcattct gtctaccaga
    13561 cagatgatcg tgaagtggaa aatgctctgg cttttgaagt gaaaaatgac gaaacagaca
    13621 agctgattct gttattaagc gaggatattc gtgtaggtga aaaattgtgc ctcgttgacg
    13681 gaacaaaaat gcgtggaaaa tgtctagtat atgataaaat aaatgagaga atgattcgct
    13741 tgcagtgcta g
//

