LOCUS AB812065 21656 bp DNA linear BCT 13-MAY-2015 DEFINITION Escherichia coli genes for O-antigen biosynthetic locus, partial sequence, strain: E1585-68. ACCESSION AB812065 VERSION AB812065.1 KEYWORDS . SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 AUTHORS Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M., Hayashi,T. and Thomson,N.R. TITLE A complete view of the genetic diversity of the Escherichia coli O-antigen biosynthesis gene cluster JOURNAL DNA Res. 22 (1), 101-107 (2015) PUBMED 25428893 REMARK DOI:10.1093/dnares/dsu043 REFERENCE 2 (bases 1 to 21656) AUTHORS Iguchi,A., Iyoda,S. and Ohnishi,M. TITLE Direct Submission JOURNAL Submitted (02-APR-2013) Contact:Atsushi Iguchi University of Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1, Miyazaki, Miyazaki 889-2192, Japan FEATURES Location/Qualifiers source 1..21656 /organism="Escherichia coli" /mol_type="genomic DNA" /strain="E1585-68" /db_xref="taxon:562" /note="serogroup:O156" gene <1..724 /gene="wcaM" CDS <1..724 /gene="wcaM" /codon_start=2 /transl_table=11 /product="colanic acid biosynthesis protein" /protein_id="BAQ01786.1" /translation="GIGMGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKH FVIRNIKARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYL SIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFM RNIKVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAMNERGQSSVDIDRIN HHIVNVEKINFRLPERRE" gene 887..1792 /gene="galF" CDS 887..1792 /gene="galF" /note="O156_01" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="BAQ01787.1" /translation="MDEIMTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIV DEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIM NVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGR SQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLS ADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYG LRNLKEGAKFRKGIENLLSE" CDS 2179..2661 /note="O156_02" /codon_start=1 /transl_table=11 /product="transposase" /protein_id="BAQ01788.1" /translation="MKRISPERKSAALAKLLPPYNMTVTAVAQMEGISEATLYYWRNKA KAEGIPVPGANKTTDQWSAEARLAVIIETATLSETELAQYCRKKGLYLEQISQWKQGFL QVSSPTDKAALKQSQKEVKQLKRELLRKEKALAEAAAILVLRKQLRDFYGETDEDD" CDS 2697..3692 /note="O156_03" /codon_start=1 /transl_table=11 /product="transposase of IS3 family" /protein_id="BAQ01789.1" /translation="MRDAMASGARLSIALTEAGLSERTWRRWQTSWEDKRVSTVRPSPV NQLSEQEEQQILAVCHQPDYASLPPSQIVPALADKGIYLASESTFYRVLRRHGEVHRRG RQRAAQKVTPATSWQASGPNEVWTWDITWVPSTVKGRWFYLYLVEDLYSRKIVGYEVHE TESGEQAAALIQRTVLREGCWQNPPVLHADNGAAMKSQTLQMKLHELAITPSHSRPGVS NDNAYVESLFRTLKYVPQWPSSGFGKLEEAREWIEVFAQWYNEMHRHSGIRYVTPGQRH RGEDGVLLKNRDEVYKKAKAERPERWSGRTRNWHPVGKVMLNPEREKQAA" gene 3956..5095 /gene="wzx" CDS 3956..5095 /gene="wzx" /note="O156_04" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="BAQ01790.1" /translation="MQQLAELGLGQTLRLHIAHAFKMDESGWCFNSKKEIKQYYSLSVK WFLVVALCTIIIIGPAGIYYYHSYQGDIIWEGPWVSLVLVTALTIIITPIQITIESLQH QISVFKAQTYASIINSISLCLLLFSGFGLYAIALSLFISNLTVLIFLWGKIKWLRNNLM PVLVDTNFFVVFKEIWPLFSRVAVVSVFGFLFWNGFNLIAFKVYEPSYAGQVILSITLA RAGYGFSESILYGQITYISNLISNKKYNEAMIVYKKNTYIALTILLIGYVFFLLLMYLF PEFYLFKKIVGSSYLISIFVFFIILLFLTSGNNYVRCFKTEPFVKVSIFHGVMVPTLFY LSSVFYEGYYLYPCSLVLIVSLILSKRISNKYFRMSGIN" CDS 5109..6071 /note="O156_05" /codon_start=1 /transl_table=11 /product="putative pyruvyl transferase" /protein_id="BAQ01791.1" /translation="MNKKDNFVNIFDTSIASLNVGDYIIMDAVTKQLSTISNLPQTVTL PTHDHFGREGRRLLSLAKYSIVGGTNLLSSHVTQYRQWRFRMTDLLFLKKCILMGVGWW QYQDKPDRVTKFILKHILHNEMLHSVRDSFTLKQLHSIGITNVINTGCPTMWDLTPEHC CNIPREKGRRVLFTLTDYNQDLSADALLINTLKRHYDEVLFWPQGSEDIHYMNTFSTDI RNGLKILRPSLSELNANLMLKETDYVGTRLHAGIRALQLRARTIIIGVDNRAIEKAKDF NLPVLKRDAILELENMIVEPLITQINMPWGNIEKWKDQF" CDS 6122..7363 /note="O156_06" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01792.1" /translation="MKILILNHSDNVGGAARAAYRLHMLFKQKFANSEMFVRVKKSDSS SVFTPKGIYSFLSKIRYPLSKFILKKLLHIWKQDLISLNMIPSSLSRIINESDADIVNI HWIAGETISFKDLSRIKKPLVWTMHDMWPFIGAEHYIDESRTDWLCGYKNLFGKFGIIN RYLWRKKLKTYSRLNICFVSPSKWLAEKAKLSGLLQGMRIEVIPNPINFDIFKPLDKEF SRKALNLSLSSKIILFGAVGGVNDQRKGYTLLYESLMHLSDKISNKENIECVFFGQSEQ PKEFAPLPFKCTWFGVVNDDVSLSLLYNAADITVVPSRMENLPQICTEAQSCGCPVVAF NTTGISETIEHNKTGYLANAFDTLDLSKAMYTLLFNNDLNKMFSANASERARFLWNGDS IAKKYESIFSSLKE" gene 7373..8578 /gene="wzy" CDS 7373..8578 /gene="wzy" /note="O156_07" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="BAQ01793.1" /translation="MENQHVYFYKKSNKANVSIVALIFTYISIIGWSPFFSGYLAVPLF LTYHIPFLLLLAYFMLTQKISSALISLSIIMIILISALTLLTESLINFNRYIFEPLTFL LCYYCTVSRKLAEKICTYASCVVIIGIVLSVISFCYAYAGGNEILTFHNVDGRLNSLYL TSFSNFKIGNIIRPSFIYDEPGAFSFVICFVVILREVLGRKYNWVYLLGGMITLSLTQF IILSLYIIVKNWKNIKQILVLCFALFGLIMFTYNNNEFDFFYNRFNTENGTFSGDNRSM QISNYLNVVNENMFLLGDYKCHDNINQRCESHGDISSSIVTPIYKGGILQLLLQIITHA IIFWLALRERKLIFPALVLTILLLQRPFFDVVGYSVMIYYSIFLMFNFKVFKDDYYHSR KK" CDS 8550..9257 /note="O156_08" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01794.1" /translation="MIIITVVKNDPDGLLKTYNSVISEIGSGLKCSRWIIKLSSDADVS LKKIINLPDYCHVYTDYDKGIYSAFNQAISKIPSSHENEYVMFLNAGDEIINGQEINKL LDLQRDNIDIFIACAKIQGKEKIIYPISSLIGVGGLNFCHQSILYRVKILKEIPFPEKY KIAGDYAHYLKIQDRDKIICTLIISTFSLDGLSGRSVYKTRLENFKAGFEHNGIREIFN FVKMIIIRVLDKI" CDS 9254..10333 /note="O156_09" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01795.1" /translation="MIAFFIGPSTGKVTGQSIAFNIIYDNYSGKKYLINYPDPDEGFLS LFKGYIQSFFVFIFINLLFFFKKKTVYITSSRTLIGFFRDAIYIIVGKLFFAKVVNHLH GADFKYFRNEQCYIIKKIIDYVYNKIDVSIVLTARMKEQYNIYRKMKIKVIGNCYFGLS YRQEKKIFNNETLKLVFLSNLLYSKGIVHLINVVKRINNEGIKVSLEIAGKILSDEYVD SCKLKEILEAKIENCPYIKYHGPLNSEKKSALLNRSDVFVLPTFYRSEAQPISVLEAMY FGCVIVTTAHNYMPDFVTAKNGIIINPDDEDDLYEALLKINNMKSIFSDVAAYNACYVK KNFSPENYINKITSVIIED" gene 10334..11452 /gene="gmd" CDS 10334..11452 /gene="gmd" /note="O156_10" /codon_start=1 /transl_table=11 /product="GDP-mannose 4,6-dehydratase" /protein_id="BAQ01796.1" /translation="MKKAFITGITGQDGSYLAEFLLDKGYEVHGIKRRASSFNTERVDH IYQDRHNQNPNFFLHYGDLTDTSNLIRLIKEIQPDEVYNLGAQSHVAVSFESPEYTADV DAMGTLRLLEAIRICGLEKKTRFYQASTSELFGLVQEIPQRETTPFYPRSPYAVAKMYA YWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGIEKCLYLGNMDS LRDWGHAKDYVRMQWMMLQQDHPEDFVIATGKQISVREFVRMSAKEVGLELEFSGQGVD EIATVVNKTSDCAIGVSIGDVIVRVDPRYFRPAEVETLLGDPAKAKKVLGWEPEITVEE MCAEMVASDLAKAKQHALLKSHGYDVAVSLER" gene 11456..12421 /gene="fcl" CDS 11456..12421 /gene="fcl" /note="O156_11" /codon_start=1 /transl_table=11 /product="GDP-L-fucose synthetase" /protein_id="BAQ01797.1" /translation="MKKKRIYVAGHRGMVGSAICRQLSLRDDIELVVKTHKELDLTVQK DVDAFFAQEKIDQVYLAAAKVGGIYANNTFPAEFIYQNLMIESNIIHSAHKAGIQKLLF LGSSCIYPKFAEQPMNESALLTGILEPTNEPYAIAKIAGIKLCESYNRQYGRDYRSVMP TNLYGINDNFHPENSHVIPALMRRFHEAKESGAPEVIVWGTGTPMREFLYVDDMAAASV HVMELDEAIYQQNSQPMLSHINVGTGVDCSIREMAETMASVVGYQGKIVFDVTKPDGTP RKLMDVTRLKNLGWQYQYNLHEGLSLTYKWFIENINSFRG" gene 12424..12885 /gene="gmm" CDS 12424..12885 /gene="gmm" /note="O156_12" /codon_start=1 /transl_table=11 /product="STP|NUDIX" /protein_id="BAQ01798.1" /translation="MNKRLERELFKTIVEHTPLISIDLIIRNDKGEALLGQRLNRPAQN YWFVPGGRIYKDESFEIAFKRITFEEVGVQISLDDALFLGVYEHFYNDNFSEAEFSTHY VVHGYEIQLKPQQLHLPTVQHNSYKWFDVVTLLNSTTVHQYTKNYFIPR" gene 12891..14297 /gene="manC" CDS 12891..14297 /gene="manC" /note="O156_13" /codon_start=1 /transl_table=11 /product="GT2|GT2_Glycos_transf_2" /protein_id="BAQ01799.1" /translation="MLLPVVMAGGSGTRLWPLSRTLYPKQFLSLNSRLTMLQETLRRLD KVEHKPALVICNESHRFIVAEQLRKEGLKHSGILLEPVGRNTAPAVALAALQAMVTGDD PILLVLAADHEIQNEDNFIDAVLAAKNFAEQGKLVTFGIVPTSPETGYGYIKSGEYLDG KGYKVAAFVEKPELHVAQQYISDGGYLWNSGMFMFRASVFINELKKFRPDILASCQRSL SSSIQDLDFIRLDNASFSCCPEESIDYAVMEKTAEAVVVPLNAQWSDVGSWSALWEISS KDQSGNAIRGDVLVEDATDSYLYSQHRLIGAVGIKDLVVVETKDAVLVAHKDKVQQVKN IVAQLKKNNRTEYLQHREIFRPWGSHDTIAEGPRFQVKHVIVLPGHITAKQIHYHRTEH WIVVSGTAKVHLEDKTYLVSENESTYIPVGVPHAIENPGKIPLEIIEVRSGVYLEEDDV IRVSSSGVGY" CDS 14297..15043 /note="O156_14" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01800.1" /translation="MRISIITATYNSEKTLLDTLLSLEKQTYPDIEYIVVDGASNDNTI KLIKSNCTKVSKIICEPDKGIYDALNKGIQAASGDVIGFLHSDDLLAYDDAIADIAKTF EITGCDAIYGDLEYVAQNDTTKRIRLWKSGSFSRFKMKVGWMPPHPSFYMKRKCYRQFG CFSLDYRISADYDSLLRYILKQRISTEYLPKVLVKMRVGGISNRSVSSMVKKSMEDIRV MNQNGIIWPIALVYKNISKLPQFIKK" gene 15049..16473 /gene="manB" CDS 15049..16473 /gene="manB" /note="O156_15" /codon_start=1 /transl_table=11 /product="phosphomannomutase" /protein_id="BAQ01801.1" /translation="MLNVKKIINDSNIAFGTSGARGLVIDFSHDVCAAFTHAFLSVIDD KYNFNKVALAIDNRPSSYEIAQACAFAIKQHGFTVEYHGVIPTPALAHYSMQKNIPCIM VTGSHIPFDRNGLKFYRPDGEITKEDELAIINSEYTFSPVGVLPHLETSTEGADYYLER YVSLFNPDILKGKRIGLYEHSSAGRDLYAPVFNQLGAEVISLGRSDEFVPIDTEAVSDE DRILAREWSKKYNLDAIFSTDGDGDRPLVADENGEWLRGDILGLLTAIELNIKALAIPV SCNTAIEQSNKFASIQRTKIGSPYVIAAFTDLAKQFNSVAGFEANGGFLLASDLQINGK ELKSLPTRDAVLPALMLLIASRNSTISQLINNLPQRFTWSDRVKNFPSDSSQQIIKNAI SSPNNFFNSLGYESLSCSAIDETDGARFTLNNGDIIHLRPSGNAPELRCYAEASDENQA KQYVTNVLGNITSLIS" gene 16670..18076 /gene="gnd" CDS 16670..18076 /gene="gnd" /note="O156_16" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase" /protein_id="BAQ01802.1" /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAE NPGKKLVPYFTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGNTF FQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA EDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQTFTEW NNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLIT ESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQL RAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADD YQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDK EGVFHTEWLD" gene 18324..19490 /gene="ugd" CDS 18324..19490 /gene="ugd" /note="O156_17" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase" /protein_id="BAQ01803.1" /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPI VDKEIQQFLQSDKIHFNTTLDKNEAYRYADYVIIATPTDYDPKTNYFNTSSVESVIKDV VEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGER SERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLG LNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANR TRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMK EDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD" gene 19580..20617 /gene="wzz" CDS 19580..20617 /gene="wzz" /note="O156_18" /codon_start=1 /transl_table=11 /product="O-antigen chain length determinant protein" /protein_id="BAQ01804.1" /translation="MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDQEQIDLIDLLVQ LWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAA PKVPDLQEALIGRFSSAFSSLAETLDNQKEPEKLTIEPSVKNQQLPLTVSYVGQTAEDA QMKLAQYIQQVDDKVNQELEKDLKDNLALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEA LQYANQAQVTKPQIQQTGEDITQDTLFLLGSEALESMIKHEATRPLVFSPDYYQTRQNL LDIENLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALR NYNSK" gene complement(20714..21325) /gene="hisI" CDS complement(20714..21325) /gene="hisI" /codon_start=1 /transl_table=11 /product="phosphoribosyl-AMP cyclohydrolase" /protein_id="BAQ01805.1" /translation="MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPQALDKT IESGKVTFFSRTKQRLWTKGETSGNFLNVVNITPDCDNDTLLLLANPIGPTCHKGTSSC FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV HDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ" ORIGIN 1 gggcatcggc atgggccttg cgggaagcac ttacgataat aattacccgg aagaccaggc 61 agtgaaaaac tttgtcgtgg cgaatatcac gggatcggat tgtcggcagt tgatccatgt 121 tgaaaatggt aaacattttg ttattcgtaa tatcaaagcc cgcaatatca caccggattt 181 cagtaagaaa gcaggtattg ataacgccac agtcgctatt tacggttgtg acaatttcgt 241 gattgataat attgaaatga ttaatagcgc cgggatgtta atcggctatg gggtaattaa 301 aggcaaatat ctctcgatac cgcaaaattt ccgagtgaat aatattcagc tggataacac 361 ccatcttgct tataaattgc gcggcattca aatctctgcc gggaatgccg tctcctttgt 421 ggcactgact aacattgaga tgaagcgtgc gtctctggag ttacacaaca aaccgcaaca 481 tctttttatg cgtaatatca aagtgatgca ggaatcctct gttggaccag cattgagcat 541 gaactttgac atgcgcaaag acgttcgcgg tgtctttatg gcgaaaaaag aaacactgct 601 gtcacttgca aatgttcatg cgatgaatga aagagggcaa agctccgtcg acatcgacag 661 gattaatcac catattgtta atgtggaaaa gattaacttt agattgccgg aacggaggga 721 gtagatttgc gaccattcct ggaaaaatgg agccatactt aggaacaatg ctactgcaat 781 ccacaacgaa gcggcgtaac atcacaagta attcagtaat caattcaggg taattgatgc 841 tggcgaaaaa aatcgaacaa gctataattc agcaaccatt ttacaggtgg atgaaataat 901 gacgaattta aaagcagtta ttcctgtagc gggtcttggg atgcatatgt tgcctgccac 961 taaggcgatt cccaaagaga tgctaccgat cgtcgacaag ccaatgattc agtacattgt 1021 tgacgagatt gtggctgcag ggatcaaaga aatcctcctg gtaactcacg cgtccaagaa 1081 cgcggtcgaa aaccacttcg acacctctta tgaattagaa tctctccttg agcagcgcgt 1141 aaagcgtcaa ctactggcgg aagtacagtc catttgcccg ccgggcgtga ccattatgaa 1201 cgtgcgtcag ggcgaaccct taggtttagg ccactccatt ttgtgtgcac gacccgccat 1261 tggtgacaac ccatttgtcg tggtattgcc agacgttgtg atcgacgacg ccagcgccga 1321 cccgctgcgc tacaaccttg ctgccatgat tgcgcgtttc aatgaaacgg gccgtagcca 1381 ggtgctggca aaacgtatgc cgggtgacct ctctgaatac tccgttattc agaccaaaga 1441 accactggat cgtgaaggta aagtcagccg cattgttgaa tttatcgaaa aaccggatca 1501 gccgcagacg ctggactcag acatcatggc cgttggtcgc tatgtgcttt ctgcagatat 1561 ttggccggaa ctagaacgca ctcagcctgg tgcatggggg cgtattcagc tgacagatgc 1621 catcgctgaa ctggcgaaaa aacagtccgt tgatgccatg ctgatgacag gtgacagcta 1681 cgactgcggt aaaaaaatgg gttatatgca ggcatttgtg aagtatggac tacgcaacct 1741 gaaagaaggg gcgaagttcc gtaaagggat tgagaatctg ttaagcgaat aatgaaaatc 1801 tgaccggatg taacggttga taagaaaatt ataacggcag tgaagattcg tggcgaaagt 1861 aatttgttgc gaatattcct gccgttgttt tatataaaca atcagaataa caacgagtta 1921 gcaataggat tttagtcaaa gttttccagg attttccttg tttccagagc ggattggtaa 1981 gacaattagc gtttgaattt ttcgggttta gcgcgagtgg gtaacgctcg tcacatcgta 2041 ggcatgcatg cagtgctctg gtagctgtaa agccaggtgc ggtagcgtgg gtaatgttta 2101 ctacctatat agttaccccc tctgtcagga tagttgtcac ccccatcgaa aatactaatg 2161 acaagatggg aacagatcgt gaaacgaatt tcaccagaac gtaaatcggc tgcactggct 2221 aaattactac cgccttacaa catgaccgtc accgcagttg cgcagatgga agggatatcg 2281 gaagctaccc tttattactg gcgtaacaag gcgaaagcag agggaatacc ggtgccgggt 2341 gcaaacaaaa ctacagacca atggtcagcc gaagcccggc tggctgtgat tatcgaaaca 2401 gctacactca gcgaaacaga actcgcgcaa tactgccgta aaaaagggct ttacctggaa 2461 cagattagtc agtggaaaca aggctttttg caggtgtctt cgcccactga caaagcggcg 2521 ctcaaacaaa gccagaaaga agttaaacaa ctaaaacgcg aactgcttcg taaggaaaag 2581 gcgctggcgg aggcggcagc gatactggtg ctgcgaaagc agttgcggga tttttacggg 2641 gaaaccgacg aggacgactg acgcccggaa cagagcggca ggcacttatc ggttacgtgc 2701 gggacgcgat ggcgtcagga gctcggctgt caatagcgct gacggaagcg ggattaagtg 2761 aacggacgtg gcgacgctgg caaacgtcgt gggaagacaa gcgtgtcagc acggtcaggc 2821 cctccccggt gaaccagtta agtgagcaag aagagcaaca gatactggca gtgtgccatc 2881 agccagacta cgccagcctc cccccgtcac aaatcgtacc ggcgttggcg gataagggga 2941 tttatctggc aagcgagtca accttttacc gggtactgcg tcgtcatgga gaggtgcatc 3001 gccggggacg gcaacgggca gcgcagaaag tcaccccggc tacgagttgg caggccagcg 3061 ggccgaatga ggtgtggaca tgggacatta catgggttcc gtcaaccgta aaggggcgct 3121 ggttttacct gtatctggtg gaagacctct acagccgaaa aatcgtggga tatgaagtgc 3181 atgaaactga aagtggtgag caggcggcag ccctgataca acgcacggtc cttcgggaag 3241 gatgctggca aaacccgccg gtactgcatg cggacaacgg cgcggcgatg aagtcacaga 3301 cgttgcaaat gaagctacac gagctggcga taaccccctc tcacagccgg ccgggagtga 3361 gtaacgataa tgcgtatgtg gagtcgctgt tccggacact gaaatatgtc ccgcagtggc 3421 cgtcatcagg gttcggcaag ctggaggagg cgcgtgaatg gatagaggtt tttgctcagt 3481 ggtataacga aatgcacaga catagcggca tcaggtatgt gacgccgggt cagcgacatc 3541 gtggagaaga cggtgtgttg ctgaaaaatc gggatgaggt gtacaaaaag gcaaaagcgg 3601 aacggcctga acgctggtct ggcagaacac gaaactggca tccggtaggc aaggtaatgc 3661 tgaatccaga acgggaaaaa caggcagcct aaatcaaccg ggggtgccaa ctaccttgac 3721 acttaccggt tacgtgcaat gaaaaataag aataagtgct gaatgatttt gattatgaat 3781 attttagatt ttttataagg aggatattat aaatatagga actaaaatct ctatttatgc 3841 ggcattatct agaggtctta aaatattaag tggacccata ataattcttg ttgtttcaaa 3901 gacattaagt tcagaggaaa ttggatttta ttatactttt ttcagcttag taactatgca 3961 gcagttagct gaattaggtt tagggcaaac attaagattg catattgctc atgcgtttaa 4021 aatggacgag tcgggatggt gttttaactc aaaaaaagaa attaagcaat actattctct 4081 aagtgtaaaa tggttcttgg tcgttgcgtt atgtactatc attattattg gtcctgcggg 4141 tatttattat tatcattctt accaagggga tattatttgg gaaggcccat gggtatcatt 4201 agtattggtt acagcactaa caattataat aacgcctata caaatcacaa ttgaatctct 4261 acaacatcaa atttcagtat ttaaagcaca gacatatgca tcaattatca atagtatatc 4321 attatgtctg ttattgtttt ctggatttgg tctatatgca attgctttaa gcctatttat 4381 cagtaactta acagtcttaa tatttttatg ggggaaaata aaatggctga gaaataacct 4441 gatgcctgtt cttgttgata caaatttttt tgttgttttt aaagagatct ggccgctgtt 4501 ttctcgtgta gctgttgtat ctgtatttgg tttccttttt tggaatggat ttaatctaat 4561 tgcatttaaa gtatatgagc cctcatatgc aggacaagta attttatcca taaccttagc 4621 gagagctggc tatggatttt ctgagtcaat tttatatggg caaataacat acatatctaa 4681 tttgatttcg aacaaaaaat ataatgaggc tatgatagtt tataaaaaaa atacatatat 4741 agcactaacg attttgttaa taggatatgt gtttttttta cttcttatgt atcttttccc 4801 agaattttac ttatttaaaa aaatagtagg ctcaagctat ttaattagta tatttgtatt 4861 ttttataata cttctttttt taacctcagg aaataactat gtcagatgct ttaaaacaga 4921 accatttgta aaagtgtcca tctttcacgg ggtcatggta ccaacattat tttatttatc 4981 atcagttttt tatgagggtt attatttata tccatgttca ttggtgttga ttgtttctct 5041 aattttatca aaaagaatat caaacaagta ttttagaatg tccggcatta attaataata 5101 ggtgaaaagt gaataagaaa gataactttg tgaatatttt tgacacaagt attgcatcat 5161 tgaatgttgg tgattacatt attatggatg ctgtgaccaa acagttatct acaataagta 5221 atttaccgca gactgttaca ttaccaacgc atgaccattt tggtagagaa gggcgacgtt 5281 tacttagctt ggctaaatat tctattgttg gcggcactaa tttattatca tcgcatgtta 5341 cacaatatcg ccaatggcgg tttcgtatga cagatctttt atttttaaaa aaatgcatat 5401 taatgggagt tggttggtgg caatatcaag ataaaccaga cagagttaca aaatttattt 5461 tgaagcatat attacacaat gaaatgttac actcagttcg tgattcattt acattgaaac 5521 aacttcattc cattggcatt actaatgtca taaataccgg ttgtccgaca atgtgggatt 5581 tgacaccaga gcactgttgc aatattccaa gagaaaaggg aagacgtgta ttatttacat 5641 taacagatta taatcaagac ttatcagcgg atgcattatt aatcaatact cttaaaagac 5701 attatgatga ggtattgttt tggccacagg ggagtgaaga tattcactat atgaatacat 5761 tcagtacaga tattagaaat gggcttaaaa ttttacgacc atcattatct gaacttaatg 5821 caaatttaat gcttaaggaa actgattatg ttgggacacg attacatgcg gggattcgtg 5881 cattgcaact tcgcgcaaga actataatta taggtgttga caatagagca atagagaaag 5941 cgaaagactt taatcttcct gtattaaaac gagatgctat tttggagctg gaaaatatga 6001 tagttgaacc acttattact caaattaata tgccgtgggg aaatattgaa aagtggaaag 6061 atcaatttta atattattct tttttgttca gtagagtttt ttaagataat ttagggaccg 6121 gatgaaaata ttaatattga atcattcaga caatgttggc ggggctgcta gggcagccta 6181 ccgattgcat atgctattta agcaaaaatt tgctaatagt gagatgtttg ttagagtaaa 6241 aaaaagtgat agctcaagtg tatttacccc aaagggcatt tattcttttt tatcaaagat 6301 acgataccca cttagcaagt ttattttgaa aaaattatta catatctgga agcaggattt 6361 aattagttta aatatgatcc catcttcttt gtcaagaata attaatgaat ccgatgcgga 6421 tattgtaaat attcattgga ttgctggaga aacaatatca tttaaagacc tatcacgaat 6481 aaaaaaacct ttagtctgga ccatgcatga tatgtggcca ttcattggcg ctgaacatta 6541 catagacgag tcaagaactg attggttgtg tgggtataaa aacctattcg gaaagtttgg 6601 tataataaat aggtacttgt ggagaaaaaa actaaaaact tacagtcgac taaatatatg 6661 tttcgtatct ccaagcaaat ggcttgcaga aaaagctaag ctgagcggtc tattacaagg 6721 tatgcgaatt gaagtaattc ctaatcctat aaatttcgac atatttaagc ctctagataa 6781 agagttttcg agaaaagcat taaatctatc tctatcatca aagataattt tatttggtgc 6841 tgtaggaggt gttaatgatc agcgtaaagg ttacactcta ctatatgaat ccttgatgca 6901 cctttcggat aaaataagta ataaagaaaa tattgagtgt gttttttttg gacagagtga 6961 acagccaaaa gagtttgctc cacttccatt taaatgtacc tggttcggtg tggtcaacga 7021 tgatgtttca ttatcgttgt tatacaacgc tgctgatatt actgttgtgc catcacgaat 7081 ggagaacttg ccacagatat gtacagaagc acaatcgtgt ggatgccctg tcgttgcatt 7141 caacactact ggaataagtg aaacaattga acacaataaa acaggttatt tggcaaatgc 7201 atttgataca ttagacttat ctaaagcaat gtatacactc ctttttaata atgatttgaa 7261 caaaatgttt tctgcaaatg caagcgaaag agcgcgtttt ctttggaatg gtgatagtat 7321 tgccaaaaaa tatgaatcca ttttctcaag tttaaaggag tgatctgagt aagtggaaaa 7381 tcaacacgtt tatttttata agaaatcaaa taaagcaaat gtttcaattg ttgccttgat 7441 ttttacatat atctcaatta ttggttggag cccttttttt agtggatatt tagctgtacc 7501 attatttcta acatatcata tacccttttt attattgctt gcttacttta tgttaacaca 7561 aaaaataagt agtgctttaa tttcattatc gataataatg attatactta tttctgcact 7621 aacattgtta acagaatcat taattaattt taatcgttat atttttgaac cgctgacctt 7681 tttgctttgc tattattgta cagtaagtag aaaacttgcc gaaaaaatat gcacatatgc 7741 atcatgtgtt gtaatcatag gcattgtgct atcagtaatt tctttttgtt atgcgtatgc 7801 aggaggtaac gaaatattaa cttttcataa tgtcgatgga cgattgaata gtttatatct 7861 aacttcattt agtaatttta aaataggaaa tattatccga ccatcattta tatatgatga 7921 acccggggca ttcagttttg ttatatgttt tgtcgttatt ttaagggagg ttttgggaag 7981 aaaatataat tgggtttacc ttcttggagg catgattaca ttaagtttaa ctcaatttat 8041 catattatca ctatatatta tagttaaaaa ttggaaaaat attaaacaaa tccttgtgtt 8101 gtgttttgca ttattcgggt tgataatgtt tacatataat aataatgaat tcgatttttt 8161 ctataataga ttcaatacgg aaaatggaac atttagcggt gataatagaa gcatgcagat 8221 ctcaaattat ttaaatgttg tcaatgagaa tatgtttctt ctgggggact ataagtgtca 8281 tgataacata aatcagagat gtgaaagtca tggtgatatt tcatcaagta tagtaactcc 8341 aatatacaaa ggcggtattc tacaactatt actacaaatt attactcatg caataatatt 8401 ttggttggca ctccgagaaa gaaaactcat attcccagcc ttagtattaa caatactact 8461 gcttcaaaga cccttttttg atgtagtggg atattcagtt atgatctatt attctatttt 8521 tttaatgttt aattttaaag tgtttaaaga tgattattat cacagtcgta aaaaatgatc 8581 cagatggact tttaaagacc tataattctg taatatctga aattgggagt ggattaaagt 8641 gcagtcggtg gattattaaa ctaagcagcg atgcagatgt ctctttaaaa aagattatca 8701 atctgcctga ttattgccat gtatatactg attatgataa aggtatttac tcagctttta 8761 accaagcaat ttcaaaaatt ccatcatcgc atgaaaatga atatgtaatg tttttaaatg 8821 ctggtgatga aattataaat ggacaagaga taaataagct tcttgatctg caaagagata 8881 acatcgatat ttttattgct tgtgctaaaa tacaaggtaa agaaaaaata atatatccaa 8941 tctcatcttt aatcggcgtt ggaggattaa atttttgtca ccagtctatt ttataccgag 9001 taaaaatatt gaaagagatt ccttttccag aaaaatataa aatagcagga gattatgcgc 9061 attatttaaa aatacaagac cgagataaga ttatatgtac tttgattatt tctacttttt 9121 ctctagatgg tttatcaggg cgtagtgttt ataaaactcg gctagaaaat ttcaaagctg 9181 gtttcgagca taatggtata agagaaatat ttaattttgt caaaatgatt attataagag 9241 tattggataa aatatgattg ctttttttat tggaccatca actggaaaag ttacaggtca 9301 atcaatagcc ttcaatataa tatatgataa ctattcaggt aaaaaatatc ttataaatta 9361 tccagatcca gatgaagggt ttttatcttt atttaaagga tatattcaat cgttttttgt 9421 tttcattttc ataaatttgt tatttttttt taaaaaaaag actgtttata taacaagcag 9481 tcgaactctg attggttttt ttcgtgatgc tatttatatt atagtcggga agttattttt 9541 tgcaaaagtt gttaatcatt tgcatggtgc tgattttaaa tattttagaa atgagcaatg 9601 ttatataatt aaaaaaataa ttgattatgt ttataataag atagatgttt caattgttct 9661 cactgcaagg atgaaggaac aatataacat atatcggaag atgaaaatca aagtaatagg 9721 taactgttat tttggtctta gttacaggca agagaagaaa atttttaata atgaaacgct 9781 aaaactagtt tttctttcta atttattata ctccaaaggg atcgtacatc taataaatgt 9841 ggtaaaaaga ataaataatg aaggtataaa ggtaagtctc gaaattgcgg gaaaaatatt 9901 gagtgatgaa tatgttgatt cgtgtaaatt gaaagaaata ttagaggcta aaattgaaaa 9961 ttgtccatat attaaatatc atggacccct gaattctgaa aagaaaagtg ctttactaaa 10021 cagatctgat gtgtttgtgt tgccaacatt ctatcgctct gaagctcagc ctatttctgt 10081 tcttgaagca atgtattttg gttgtgtgat tgtaacgacg gctcataatt atatgccgga 10141 ttttgttacg gcgaagaatg gtatcattat taatcctgat gatgaggacg atttatacga 10201 agctttatta aaaatcaata atatgaagag tatattttct gatgttgcag catataatgc 10261 ctgctatgtt aaaaaaaatt tttctccaga aaattatata aacaaaatta cttcagtaat 10321 aatagaggat taaatgaaaa aagcatttat tacaggcatc accgggcaag atggctctta 10381 tttggctgaa tttcttcttg acaaaggcta tgaagtgcat ggcattaagc gtcgagcatc 10441 ttcgtttaac acagaacgtg ttgatcatat ttatcaagat cgccacaacc aaaatccaaa 10501 tttctttctt cattatggtg acttaacaga tacatcaaac ctgatacgtc taatcaaaga 10561 aatccaacca gacgaagttt ataaccttgg cgctcaatct catgtagcgg tttcattcga 10621 atcacctgaa tatactgctg acgtagatgc gatggggact ttacgtctgc tggaagcgat 10681 tcgtatttgt gggctagaga aaaaaacacg tttttatcag gcatcaactt ctgaactctt 10741 cggcttagtt caggaaatcc cgcagcgaga aacaacacca ttctaccctc gttcgcctta 10801 tgctgttgcg aagatgtatg catactggat tactgtaaac tatcgtgaat cctatggaat 10861 gtatgcctgt aacggtattc tcttcaacca tgaatccccg cgtcgtggtg aaacattcgt 10921 aacacgtaaa atcactcgtg ctattgcaaa tatttcgcag ggaatcgaaa aatgtctcta 10981 tcttggcaat atggattcac tgcgcgactg gggacatgcg aaagattacg tgcgtatgca 11041 gtggatgatg ttgcagcaag atcacccaga ggattttgtt attgcaacag gcaaacaaat 11101 ttccgtacgt gaatttgttc gtatgtcagc taaagaagtc ggtctggagt tagaattctc 11161 cggacaaggt gttgatgaaa tagcaactgt tgtgaataaa acatctgact gtgctattgg 11221 tgttagtatt ggggatgtga tcgttcgtgt tgatcctcgt tatttccgtc ctgcagaggt 11281 tgaaactctt cttggtgatc cagcaaaagc gaaaaaagta ttgggttggg aaccagagat 11341 tacagttgaa gagatgtgtg cagaaatggt tgccagtgat ctggcgaaag caaaacagca 11401 tgcactactg aaaagccatg gttacgatgt tgcagtttct ctggagcggt aaggtatgaa 11461 aaaaaaacgt atctacgttg ctggtcaccg aggcatggtt ggctctgcta tttgccgtca 11521 attatcactg cgtgatgata tcgaattagt ggtcaaaaca cacaaagaac tcgatctaac 11581 cgtacagaag gatgttgatg cattttttgc gcaagagaaa attgatcagg tttatcttgc 11641 tgcggctaaa gttggtggca tttatgccaa caatacattt ccggctgaat tcatctatca 11701 gaatctcatg attgagagta atattattca ttcagctcac aaggccggaa ttcaaaaatt 11761 acttttttta ggctcaagct gtatttatcc taaattcgca gagcagccga tgaacgagtc 11821 tgcgctttta acgggcatac ttgagccaac taatgagcca tacgcaattg ctaaaattgc 11881 gggcataaaa ttatgtgaat cttataaccg tcaatatggc cgtgattatc gcagtgtaat 11941 gcctactaat ctttatggca taaatgataa tttccacccc gaaaactctc atgttattcc 12001 ggcactcatg cgtagattcc atgaggcaaa agagagtggt gcaccagaag ttattgtctg 12061 gggaacagga acaccgatgc gtgagttttt atatgttgat gatatggctg ccgcatctgt 12121 tcatgtaatg gaacttgacg aagcaattta tcaacaaaat tcacagccta tgttatctca 12181 tattaatgtt ggtacgggtg tagattgttc catacgtgaa atggctgaaa caatggcctc 12241 tgtggtgggt tatcaaggta aaattgtttt tgatgttact aaacctgatg gcactccgcg 12301 taaacttatg gacgttaccc ggctcaaaaa cttgggctgg caatatcaat ataatttaca 12361 tgaaggctta tcattaacat ataaatggtt tattgagaat attaattctt ttcggggata 12421 gttatgaata agagattgga acgtgagcta tttaaaacaa tagttgagca tactcctcta 12481 atctcgattg atctcataat tagaaacgat aaaggagagg cgctgctggg gcagcgcctg 12541 aatcgcccag cacaaaatta ttggtttgtg ccaggagggc gaatttataa ggatgagtca 12601 ttcgagattg catttaagcg gataacattt gaagaggtgg gcgttcaaat tagtcttgat 12661 gatgccttat ttctaggggt gtatgaacat ttttacaatg ataatttttc tgaagcagaa 12721 ttttctacac actatgtagt gcatggatat gaaatccaac ttaaacctca gcaacttcac 12781 ctaccaacgg tccagcataa ttcctacaag tggtttgatg tagtaacgtt gcttaatagc 12841 actacagttc atcaatatac caaaaattat tttataccaa ggtaatagat atgctacttc 12901 ccgttgtcat ggccggtggt tctggtacca gattatggcc tctttcacgt acactttatc 12961 cgaaacaatt tctatcttta aatagtcgtt taaccatgtt gcaagagaca ttgcggcggc 13021 ttgacaaggt agaacataaa cccgctttgg tcatttgtaa cgaatcacat cgctttatcg 13081 ttgctgaaca attgcgtaaa gagggtttaa agcatagcgg tattttgctt gagcctgttg 13141 gccgtaatac tgcgcctgct gtagcactcg cagcacttca ggctatggta actggagatg 13201 atcctattct gttggttctt gctgctgatc atgaaattca gaatgaggat aatttcattg 13261 atgcagttct tgcagccaag aattttgcag aacagggtaa gcttgttacg tttggtattg 13321 ttccaacatc cccagagact ggctatggtt acattaagtc aggtgagtat ctggatggaa 13381 aaggttacaa agttgcggct tttgttgaaa aaccagagct tcacgtagct cagcagtata 13441 tatcagatgg cggttatctt tggaatagtg ggatgtttat gttcagagca tctgtattta 13501 tcaatgaact gaaaaaattc cgaccagata ttttagccag ttgccaacgc tccttgtcct 13561 cttcgataca agatttagat tttatccgtc tggataatgc ttcattttct tgctgtcctg 13621 aagagtctat tgactatgca gttatggaaa aaacagccga agctgtcgtc gttcccttaa 13681 atgcacaatg gagtgatgtt gggtcatggt ctgcattgtg ggaaataagt tcaaaagatc 13741 aaagcggtaa tgccattcgt ggtgatgtat tggttgaaga tgctacagat agttatcttt 13801 attcgcagca tagacttatt ggtgctgtgg gcataaagga tttggttgtt gttgaaacga 13861 aagatgccgt attagttgct cataaagata aagttcagca agttaaaaac atcgtcgctc 13921 aacttaaaaa gaataatcgc acagaatatt tacagcatcg ggaaatattt cggccttggg 13981 gcagtcatga tactatagct gaagggccgc gctttcaagt gaaacatgtg attgtattac 14041 ctggccacat taccgctaag cagattcatt accatcgtac tgagcattgg attgttgtct 14101 cggggacagc taaagtccat cttgaagata agacttacct tgtttctgaa aatgaatcaa 14161 catatatacc tgttggtgtt ccacatgcca ttgaaaatcc tggcaagatc ccgcttgaaa 14221 taatcgaggt tagatcagga gtctacctgg aagaggatga tgttataaga gtttcttctt 14281 ctggagtagg atactaatgc gaatttctat tatcacagct acttataata gtgaaaaaac 14341 tctccttgat acattacttt ctctagaaaa acaaacgtat ccagatatcg aatatatagt 14401 tgtagatgga gcatcgaacg ataatacaat taagctgatc aagagtaatt gtacaaaagt 14461 ttcaaaaatc atttgcgaac ccgataaggg catttatgat gctctgaata aaggtattca 14521 agcagcttcg ggtgatgtta ttggtttttt acattctgat gatttattag cttatgatga 14581 tgctattgca gatatagcaa aaacatttga aattacaggg tgtgatgcta tttatggcga 14641 tttggagtat gttgcccaaa atgatacgac taaacgtatt agattatgga aaagtggttc 14701 atttagtcgt ttcaagatga aagtgggttg gatgccgcca cacccatcat tttatatgaa 14761 acgcaaatgt tataggcagt ttggttgttt ttctttagat tatcgaatat ctgctgatta 14821 tgactcatta ttacgatata ttttaaaaca acgtatttca acagaatatt taccaaaagt 14881 cttagtgaag atgcgtgttg gtggaattag caatcgttca gtatcttcaa tggtaaagaa 14941 gtcaatggaa gacattcgtg ttatgaacca gaatggtatt atctggccaa tagctttagt 15001 gtataaaaat atatccaaac ttcctcaatt tattaaaaag taatcatcat gttaaatgtt 15061 aaaaaaatca ttaacgatag taatattgcg ttcggtacta gtggtgctcg cggtttagtg 15121 atcgattttt cccatgatgt ttgtgctgcg ttcactcatg cgtttctttc tgttattgat 15181 gacaaataca attttaataa agttgcctta gcaattgata accgcccaag cagttacgaa 15241 atcgctcagg catgcgcctt cgctatcaaa caacatgggt tcactgtcga atatcatggt 15301 gtaattccga ctcccgcatt agctcattat tcgatgcaga aaaacattcc ctgcataatg 15361 gtcacaggga gtcatatccc ttttgatcgt aatggcttaa aattctacag acctgatggt 15421 gaaatcacta aagaggatga gctcgcaatt ataaatagtg agtatacatt ttcgcctgta 15481 ggtgtattac ctcatcttga aacaagcact gaaggtgcag actactacct tgagcgttat 15541 gtttctcttt ttaatcctga tattttaaag gggaaaagaa tagggctata tgaacattct 15601 agtgcaggac gcgatttata tgctcctgtt tttaatcaat tgggtgcaga ggtcatttcc 15661 ttaggtagaa gtgatgagtt cgttcctatt gatacggaag cagtaagcga tgaagatcgc 15721 atacttgcaa gagagtggtc taaaaaatat aatcttgatg ctattttctc aacagatggc 15781 gatggtgatc gtcctttagt tgccgatgaa aatggtgaat ggctaagagg cgatattctg 15841 ggattactta ctgctattga acttaatatc aaggcgttgg ctattccagt gagttgtaat 15901 acagcaattg aacagtctaa taaatttgca agtatacaac gaacgaaaat aggttctcct 15961 tatgtaattg cagcgtttac agatcttgct aagcaattta attcagtcgc tggttttgaa 16021 gctaatggtg gctttctcct tgcctccgat ttacaaatta atggcaagga attaaaatcg 16081 ttacctacac gagatgctgt gttaccagca ttaatgctct taatagcttc tcgcaatagt 16141 actatttctc aactgattaa taatcttcct cagcgattca cttggtcaga tagagttaaa 16201 aacttccctt cagattcaag tcaacaaatt ataaaaaatg ccatatcgtc acccaataat 16261 ttctttaata gtttaggtta tgaatcatta tcctgttccg ctattgatga aacggatggt 16321 gcaagattta ctttaaataa tggtgatatt atacatctcc gtccttccgg taatgctcca 16381 gaactccgtt gttatgctga ggccagtgat gaaaatcagg ctaagcaata tgttacgaat 16441 gtgctgggaa atattacctc tttgatttct tgatgttata ggtttatcta cgcttatacg 16501 tgtgcgtagg tttgattaca cgtagatgcc ggtatacaga attgaagaac ggtatttgtt 16561 gcattaatga aattcagcac tacacacatt cgtgcaactt gagataacat ctcaatcata 16621 ttcaagtcgc gcatacatcg cggtgaacac cccctgacag gagtaaacaa tgtcaaagca 16681 acagattggt gtcgtcggta tggcagtgat ggggcgcaac cttgcgctca acatcgaaag 16741 ccgtggttat accgtctcta ttttcaaccg ttcccgtgag aagacggaag aagtgattgc 16801 cgaaaatcca ggcaaaaaat tggttcctta ctttacggtg aaagagtttg ttgaatctct 16861 ggaaacgcct cgtcgcatcc tgttaatggt gaaagcaggt gcaggcacgg atgctgcaat 16921 tgattccctc aaaccatatc tcgataaagg tgacatcatc attgatggtg gtaatacctt 16981 cttccaggac accattcgtc gtaaccgtga gctttctgct gaaggcttta acttcattgg 17041 taccggtgtt tccggtggtg aagagggcgc gctgaaaggg ccttccatca tgcctggtgg 17101 ccagaaagaa gcctatgaac tggttgcgcc gatcctgacc aaaatcgccg ccgttgctga 17161 agatggcgaa ccgtgcgtta catatattgg tgccgatggt gcgggtcact atgtgaaaat 17221 ggttcacaac ggtattgaat acggtgatat gcaactgatt gctgaagcct attctctgct 17281 taaaggcggc ctgaatctct ctaacgaaga actggcacag acctttaccg agtggaataa 17341 cggtgaactg agcagctacc tgatcgacat caccaaagat atcttcacca aaaaagatga 17401 agacggtaac tatctggttg atgtgatcct ggatgaagcg gctaacaaag gtaccggtaa 17461 atggaccagc cagagcgcgc tggatctcgg cgaaccgctg tcgttgatta ctgagtctgt 17521 gtttgcacgt tatatctcgt ctctgaaaga tcagcgcgtg gccgcatcta aagttctctc 17581 tggcccgcaa gcacagccag caggcgacaa ggctgagttc atcgaaaaag ttcgccgtgc 17641 gctgtatctg ggcaaaatcg tttcttacgc tcagggcttt tctcagctgc gtgctgcgtc 17701 tgaagagtac aactgggatc tgaactacgg cgaaatcgca aagattttcc gtgctggctg 17761 catcatccgt gcgcagttcc tgcagaaaat caccgatgca tatgccgaaa atccgcagat 17821 cgctaacctg ctgctggctc cgtacttcaa gcaaattgcc gatgactacc agcaggcgct 17881 gcgcgatgtc gtcgcttatg cagtacagaa cggtatcccg gttccgacct tcgccgctgc 17941 ggttgcctat tacgatagct accgtgccgc tgttctgcct gcgaacctga tccaggcaca 18001 gcgtgactat ttcggtgcac atacttataa gcgcattgat aaagaaggtg tgttccatac 18061 tgaatggctg gattaatctt atttaactaa caataaattg aggcctggcg tatattgcgc 18121 cgggcttttt tttgccaatt atcttataga ctaaatttca ctgcttaata ttaacttaat 18181 aaatatcagc tattcttata aagaaaatct gaattgtttt tcgttgcgtt gaccatctga 18241 caacgtagcg ttaaaacttt tagctcttat caggatgcta aaaacatcat gattcacagt 18301 taagttaatt ctgagagcat gaaatgaaaa tcaccatttc cggtaccggc tatgtaggct 18361 tgtcaaacgg gcttctaatc gcacaaaatc atgaggttgt ggcattagat attttaccgt 18421 cacgcgttgc tatgctgaat gatcggatat ctcctattgt tgataaggaa attcagcagt 18481 ttttgcaatc agataaaata cactttaata ccacattaga taaaaatgaa gcctaccggt 18541 atgctgatta tgtcatcatc gccactccaa ccgactatga tcctaaaact aattatttca 18601 atacatccag tgtagaatca gtaattaaag acgtagttga gataaatcct tatgcggtta 18661 tggtgatcaa atcaacggtt cccgttggtt ttaccgcagc aatgcataag aaatatcgta 18721 ctgaaaatat tattttctct ccggaatttc tccgtgaagg taaagctctt tacgataatc 18781 tccatccttc acgtattgtc atcggtgagc gttcagaacg cgcagaacgt tttgctgcgt 18841 tgttacagga aggcgcgatt aagcaaaata tcccgaccct gtttaccgac tccactgaag 18901 cagaagcgat aaaactgttt gctaatacct atctggcgat gcgcgtagca tactttaatg 18961 aactggatag ctatgcagaa agtttaggtc tgaatactcg ccagattatc gaaggcgttt 19021 gtctcgaccc acgcattggc aaccattaca acaatccgtc gtttggttat ggtggttatt 19081 gtctgccgaa agataccaag cagttactgg cgaactacca gtctgtgccg aataacctga 19141 tctcggcaat tgtcgatgct aaccgcacgc gtaaagactt tattgccgat gccattttgt 19201 cacgcaagcc gcaagtggtg ggtatttatc gtctgattat gaagagcggg tcagataact 19261 tccgtgcgtc ttccattcag gggattatga aacgtatcaa ggcgaaaggc gttgaagtga 19321 tcatctacga accggtgatg aaagaagatt cattcttcaa ctctcgcctg gaacgtgatc 19381 tcgccacctt caaacaacaa gccgatgtca ttatttccaa ccgtatggca gaagagctta 19441 aggatgtggc agacaaagtc tacacccgcg atctctttgg tagtgactaa catcctgtta 19501 tcagggcgat tttcgccctg attctcttat gttccctttg taataattca ttatttttat 19561 catttatcct atagcattca tggcgattat cgctaaacta tggcgactta aaattatttc 19621 gtccgttagg gtaatgatga gagtagaaaa taataatgtt tctgggcaaa accatgacca 19681 ggaacagatt gatttgattg atttactggt gcagttgtgg cgtggcaaga tgacaattat 19741 catctctgtc attgttgcta ttgccctggc tattgggtat ttggcggtag cgaaggagaa 19801 atggacgtca acagcaatta tcactcagcc tgacgtgggg caaattgctg gctataacaa 19861 tgccatgaat gttatctatg gtcaggctgc acctaaagtg ccggatttac aggaggcgtt 19921 aattggtcgc ttcagttctg ccttctcttc attagcagaa acgctggata atcagaaaga 19981 accagaaaaa cttaccatcg aaccttctgt aaagaaccag caattaccat tgactgtttc 20041 ttatgttggg caaactgcag aggacgcaca aatgaaattg gcccaataca ttcagcaagt 20101 tgatgataaa gtaaatcaag agctagaaaa ggatctcaag gacaaccttg ctttgggacg 20161 gaaaaacttg caggactctt taagaactca ggaagtggtt gcgcaggagc agaaagatct 20221 gcgtatccgt cagattcagg aagcgttgca gtatgcgaat caggcgcagg tgacaaaacc 20281 gcagattcaa cagactggcg aagatatcac acaagatacg ttgttccttt tggggagcga 20341 agcgctggag tcgatgatta agcatgaggc aactcgtccg ttggtgtttt cgccagacta 20401 ctatcagact cgtcaaaacc tgctggatat cgaaaactta aaggttgacg atcttgatat 20461 tcatgcttac cgttatgtga tgaaaccgac gttacctatt cgtcgcgata gcccgaaaaa 20521 ggcaattacc ttgattctgg cggtgctgct gggcggcatg gttggcgcgg ggattgtgtt 20581 ggggcgtaat gctctgcgta attacaactc gaagtaatct tttcggtttt aaagaaaatg 20641 ggcagggtgg tgacaccttg cccgtttttt ttgccggatg cgacgacaat atcgcatccg 20701 cttaccccgc aactcactga tgccgtttac gcaggttctc aatcaccgtc gttaagtcca 20761 gatcctgatc ctgcaatagc accagcaggt gatacatcaa atcagatgcc tcgttggtca 20821 gctcaaagcg gtcatgtact gtcgctgcca gtgcggtttc cacgccttct tcgcccactt 20881 tctgcgcaat gcgcttggtg ccgctggcat acagtttggc ggtataggag gtttccgggt 20941 cggcagattt acgttcggcg agcagttgtt ccagttgata caggaacagc cactggtgag 21001 cggtgtcgcc gaagcagctg ctggtgcctt tgtggcaggt cgggccgatg ggattcgcca 21061 gcaacagtaa cgtgtcgttg tcgcagtccg gcgtaatatt tactacgttg aggaaattgc 21121 ccgacgtttc gcctttggtc cacagtcgct gtttagtgcg cgagaagaag gtgactttgc 21181 cgctttcgat ggttttgtcc agggcttgcg ggttcatata gcccagcatt aacacttcac 21241 cggataccgc gtgttgcaca atcaccggca taagtccgtc ggttttttcc cagtccagtt 21301 cgcgacgttg ttgttctgtt aacatatcct gatctccacg ccctgtgttg ccaggtacgc 21361 ttttaattca ccaatattga ttatttgttt gtggaatacg gaagctgcca gcgcgccgtc 21421 aacgtcggca tcgcggaagg cttcgaggaa gtgttccatg gtgcccgcgc caccggaggc 21481 aatcagcggg acgtggcaaa cttcacgcac ttttttcagc tgctcgaggt cgtaaccgtt 21541 acgcacaccg tcctgattca tcatgttgag gacgatttct ccggcaccgc gtttttgcac 21601 ttcctctacc cagtcgagtg tttcccactg agtgacgcgg gtgcggcttt catcgc //