LOCUS NZ_ABQA01000009 13682 bp DNA linear CON 04-FEB-2020 DEFINITION Enterococcus faecium E980 Contig00009, whole genome shotgun sequence. ACCESSION NZ_ABQA01000009 VERSION NZ_ABQA01000009.1 DBLINK BioProject: PRJNA224116 BioSample: SAMN02471501 Assembly: GCF_000172615.1 KEYWORDS WGS; RefSeq. SOURCE Enterococcus faecium E980 ORGANISM Enterococcus faecium E980 Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus. REFERENCE 1 (bases 1 to 13682) AUTHORS van Schaik,W., Top,J., Riley,D.R., Boekhorst,J., Vrijenhoek,J.E., Schapendonk,C.M., Hendrickx,A.P., Nijman,I.J., Bonten,M.J., Tettelin,H. and Willems,R.J. TITLE Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island JOURNAL BMC Genomics 11, 239 (2010) PUBMED 20398277 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 13682) AUTHORS van Schaik,W., Top,J., Bonten,M.J.M. and Willems,R.J. TITLE Direct Submission JOURNAL Submitted (24-NOV-2009) Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands COMMENT ##Genome-Assembly-Data-START## Genome Coverage :: 19x Sequencing Technology :: 454 ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 02/04/2020 07:40:48 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Method :: Best-placed reference protein Annotation Software revision :: 4.11 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; Genes (total) :: 2,759 CDSs (total) :: 2,694 Genes (coding) :: 2,571 CDSs (with protein) :: 2,571 Genes (RNA) :: 65 rRNAs :: 1, 1, 1 (5S, 16S, 23S) complete rRNAs :: 1, 1, 1 (5S, 16S, 23S) tRNAs :: 58 ncRNAs :: 4 Pseudo Genes (total) :: 123 CDSs (without protein) :: 123 Pseudo Genes (ambiguous residues) :: 0 of 123 Pseudo Genes (frameshifted) :: 58 of 123 Pseudo Genes (incomplete) :: 42 of 123 Pseudo Genes (internal stop) :: 33 of 123 Pseudo Genes (multiple problems) :: 10 of 123 ##Genome-Annotation-Data-END## REFSEQ INFORMATION: The reference sequence was derived from ABQA01000009. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Annotation Pipeline (PGAP) set; GeneMarkS-2+ repeat_region FEATURES Location/Qualifiers source 1..13682 /organism="Enterococcus faecium E980" /mol_type="genomic DNA" /submitter_seqid="Contig00009" /strain="E980" /isolation_source="healthy human volunteer" /host="Homo sapiens" /db_xref="taxon:529885" /country="Netherlands" /collection_date="1998" gene complement(1..1461) /gene="gtfA" /locus_tag="EFME980_RS04995" /old_locus_tag="EfmE980_0216" CDS complement(1..1461) /gene="gtfA" /locus_tag="EFME980_RS04995" /old_locus_tag="EfmE980_0216" /EC_number="2.4.1.7" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002290364.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GH13|GH13_18" /protein_id="WP_002290364.1" /translation="MKIKNEAMLITYADSLGKNMGELKQVLDKHLQGVIGGVHLLPFFP STGDRGFAPSDYTTVDPALGTWEDVEALGEDYYLMFDFMINHISRESKFFQDFKKNHEQ SPYKEMFIRIHEFFPENRPTQEDIDLIYKRKDKAPFQTVEFADGTTEEVWNTFGEEQID LDVTKEVVKEFIRETIKDMANHGCSLIRLDAFAYAIKKLDTNDFFVEPDIWELLDEVRQ EAAKYDVELLPEIHEHYSIQMKIANHDYYIYDFASPMVTLYSLYSGKSERLANWLKMSP MKQFTTLDTHDGIGVVDARDLLTDEELDYTSEELYKVGANVKKVYSSANYNNLDIYQIN STYYSALGDNDRSYLLARAIQVFAPGIPQIYYVGLLAGKNDIELLEATKEGRNINRHYY DLAEIEEEVQRPVIQQLFALLKFRNESAAFDLDGTIEVATPSESEIVITRKNKNGSDSA TLTANLDTKEFIIESKDIKIFTSVALKF" gene complement(1458..2441) /locus_tag="EFME980_RS05000" /old_locus_tag="EfmE980_0217" CDS complement(1458..2441) /locus_tag="EFME980_RS05000" /old_locus_tag="EfmE980_0217" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002405320.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GH13_31|GH13" /protein_id="WP_002290365.1" /translation="MWLKEMRERTFKPHNSMTVAEADVPNERLDEYIGEDGYYSMVFDF SYTDIDVPETGEWFKDSQWTWTDMRTNIFTNQLVTQDKGWGALYLENHDQPRSINKYIP EEWINDYSKKMLATLFMLLRGTPFIYQGQKLGMTNIEMASLEDFDDVATHSQYKRALEY GLAPEQALKAVNKRSRDNSRTPMQWNTQKNARFSTSDNVWLKVNPNYPELNAEAQLTNQ QSVFNYYHQLIKLRKNSVYKDVLIYGQFLPVKDKNEHILLYERQLEDKIVLVILNVTAT EQEYYVDEQYQQVLINNYEDVLLDQSRKLRLRPFESIVLANYGGQL" gene complement(2522..2677) /locus_tag="EFME980_RS05005" /old_locus_tag="EfmE980_0218" CDS complement(2522..2677) /locus_tag="EFME980_RS05005" /old_locus_tag="EfmE980_0218" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002290366.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="oligo-1,6-glucosidase" /protein_id="WP_002290366.1" /translation="MFYLHAFTKKQPDLNWENEEVREEIYAMINYWLDKGLGGFRIDAI LNIKKN" gene complement(2738..4921) /locus_tag="EFME980_RS05010" /old_locus_tag="EfmE980_0219" CDS complement(2738..4921) /locus_tag="EFME980_RS05010" /old_locus_tag="EfmE980_0219" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016175926.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GH36" /protein_id="WP_002290367.1" /translation="MIIFDNHTQTFHLQNKKISYLLGIEENNYLTHLYFGKKITHYSGG YRYPRTDRSFSPNNANAQDRLLSLDTLPLEFPGYGHGDFREPAHNIKLGNGSRVNDFRY DSYEIQKGKPSLAGLPALYTEDDDEAETLIIQLKDAISGLTLQLFYTIYQNHSVIIRST QLVNNSDETVEINRLASQSIDFPNRPLELIHLNGTWARERQMTREKIHTGIKVLDSKRG SSSHQQNPFVALVDAKTDEFQGEAYGFNLVYSGNHETVIQKDPFDQTRVIMGINSFNFG WQLKTGDSFQTPEVVMVYSNEGLNTLSQTYHELYNHRLIRGNYRLKERPTLINNWEATY FDFNEEKIMNIVDDAKNLGIEMFVLDDGWFGGRENDFTSLGDWVETEGKLACGLENLAK QVHDNGMKFGIWFEPEMISEDSELFRAHPDWALGIPGRDRSISRNQYVLDFSRQDVRDN IYQQMTAIFDRVPIDYVKWDMNRNMTEVYSVLLDSTMQGEVAHRYMLGLYEFLEKLTTN YPTILFESCSGGGGRFDAGFLYYMPQTWTSDNTDAVARLKIQYGTSLVYPISSMGAHVS AVPNHQTGRETSLTIRGNAAMAGVFGYELDLTQLTSEEKAEIKEQVAFYKKHRQLLQYG TFYRLESPFEGNDTAWMFVSKDQTEAMVFYFRVLAEAAHPLVTLKLAGLAEEATYQMED VTFAGDELMNLGFYIDSELHGDYATQRFYLKQI" gene complement(4961..5791) /locus_tag="EFME980_RS05015" /old_locus_tag="EfmE980_0220" CDS complement(4961..5791) /locus_tag="EFME980_RS05015" /old_locus_tag="EfmE980_0220" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_000711263.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q00751|3.A.1.1.28" /protein_id="WP_002290368.1" /translation="MKTSKEKNISKYLLLLLGGFMILVPLVSTLFGSFKTTPDIMNNFF RFPNPATLENFRRLLADGIGHYFWNSAIITIIAVVAVTAIIPMAAYSLARKMTRGKAYG LMYLFLILGIFVPFQVIMIPITVMMSKIGLANMWGLILLYLTYAVPQTLFLYVGFIKLN VPISLDEAAEIDGASHFTTYFKIVFPMLKPMHATTIILNALWFWNDFMLPLLILNRDSN MWTLPLFQYNYTGQYFNDYGPSFASYTVGIVTITLVYLAFQRSIIAGMSNGAVK" gene complement(5803..6675) /locus_tag="EFME980_RS05020" /old_locus_tag="EfmE980_0221" CDS complement(5803..6675) /locus_tag="EFME980_RS05020" /old_locus_tag="EfmE980_0221" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018363968.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q00750|3.A.1.1.28" /protein_id="WP_002290370.1" /translation="MKIKEILNRYWAIIFVAIPIILQMIFFYFPMVQGAFYSLTNWTGL TYNFDFVGLNNYKILFSDPKFIKSIGFTLIVTLCMIAGQIGFGILIARALNANIKGKTF FRAWFFFPAVLSGVVVSLVFKQIFNYGLPKIGSMLGIEFLQTSLLGTTWGAIFAVIFVL LWQGIAMPVIIFLAGFQSIPQEIIEAARMDGANDKQIFWNIEITYLLPSISMVFIMALK GGLTAFDQIFALTGGGPSDATTSLGLLVYNYAFKNNQFGYANAIALVLFILIGIVSLAQ LKLSKKFEI" gene complement(6685..7944) /locus_tag="EFME980_RS05025" /old_locus_tag="EfmE980_0222" CDS complement(6685..7944) /locus_tag="EFME980_RS05025" /old_locus_tag="EfmE980_0222" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002343070.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q00749|3.A.1.1.28" /protein_id="WP_002290371.1" /translation="MKWSKKIILACIALGATISLTACGKNQEDASGKVEIEFFNQKKEM TQTIQEIAKDFEAKNPDIHVKVVDVPNAGEVIKTRMLAGDVPDVINLYPQSIELKEWAK AGYLEDLTEEPYLENIKNGYAQRFAIEDRVYSIPLTANVYGFYYNKTAFEEMGIQAPET WAEFEKIVAEIKDQNKVPFAIAGAEGWTLNGYHQLAIATAAGGEEEANNVWRFSEVNGI NAESKEMQKDFNRLDLLREPKALQNNWQGAGYNDTVVTFTKGDALIMPNGSWAMPMIHS QNPDFEVGTFPFPADEAGQSLTIGAGDLALSVSATSQHKEEAKRFVEYMTTPEAMQKYY DVDGAPCAVEGVIENTQDSPLSGLTELAFTDRHLVWLAKDWNSENDFYTLTTNYLHNGN QKAMINALNAFFNPMKADGR" gene complement(8093..9403) /locus_tag="EFME980_RS05030" /old_locus_tag="EfmE980_0223" CDS complement(8093..9403) /locus_tag="EFME980_RS05030" /old_locus_tag="EfmE980_0223" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005235059.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GH4" /protein_id="WP_002290372.1" /translation="MTKITFIGAGSTIFAKNVLGDAMLTPSLQDAHIALYDIDEKRLKE SNLMLKNINKNSNENRADIVSYYDRKEALREADFVINAIQVGGYKPSTVIDFDIPKKYG LRQTIGDTMGIGGIFRTLRTLPVMLDFAKEMEEVCPNAWLLNYTNPMAMLTMGVLKATS IKTVGLCHSVQVCVPELFEHLGIADQYDLNDFQWKIAGINHMAFLLEITKNGEDFYPTI RQLAAEKPNPHPDSVRFELLKRFGYYITESSEYNAEYHPYFIKSKYPELIDELGIPLDE YLRRCEQQINDWESMREDIVNNGELTHTRSREYASYIMDSITTGTPSVIAGNVLNKGLI TNLPTDVCVEVPCLVDKNGVQPTYVGELPTQLAALNRTNINVQELTVEAALTLDKSKIY QAAYLDPHLSSELSLTDIKNLVDDLIEAHGDYLPEYN" gene complement(9435..10259) /locus_tag="EFME980_RS05035" /old_locus_tag="EfmE980_0224" CDS complement(9435..10259) /locus_tag="EFME980_RS05035" /old_locus_tag="EfmE980_0224" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002579255.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q93J92|3.A.1.1.36" /protein_id="WP_002290373.1" /translation="MKNKFFSNAPIHIMLILGGIAMALPFIWMILTSGKTLVESTQIPP TIFPEKFQLSNYQQVLDLLPFMAFYINTFLMVVGRVIGSVLFSAMAAYACARLSFPGKN ILFSLVLIQMMIPGSIFITPQYLLAQKLGILNTIPALILPGVVSAFGTFLLRQFFLGLP DELEEAAYLEGANIWTIFFKIMLPLAKSGLVALGIFTALFAFKDLMWPLIVNTSIDKMP LAPGLANLQGQYATNFPQLMAGSLLAIWPIVVIFIVFQRKFIEGIATTGGKL" gene complement(10275..11171) /locus_tag="EFME980_RS05040" /pseudo="" CDS complement(10275..11171) /locus_tag="EFME980_RS05040" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008378728.1" /note="internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo="" /protein_id="WP_008378728.1" /codon_start=1 /transl_table=11 /product="sugar ABC transporter permease" gene complement(11254..12363) /locus_tag="EFME980_RS05045" /old_locus_tag="EfmE980_0226" CDS complement(11254..12363) /locus_tag="EFME980_RS05045" /old_locus_tag="EfmE980_0226" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002290375.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q9WZR7|3.A.1.1.40" /protein_id="WP_002290375.1" /translation="MLDEFEKQNPDIKVEMETTPWDQYWVKLEAATTGGNMPDVVTMHS SESYKYMSQNALMGLDDVIKENDIDMGNFTEGIADFYTLEDELYAIPKDASVVGLWYNK ELFDNAGVDYPDETWTWETLRQAAIDLTDESKGIYGFASHIGTETGYWPFIYQNGGEVF ADDNTKSGLNTPEAQEALAFYRDIALVDHASPTITELQDPDKLSRFQSGRLAMMIEGNW FAPGFLKNDYLVENVASAVLPKGKVNATITNGLGWAASANTKYPEEVKKLMAFLASEDA NKIQAETGASIPALKGFEDEWAASSDTIDLSTFGKMLEYGVPRPYNKDGLRAEQAEVQI INRILSGEVTVEDGTAQIEKEVNAILSGN" gene complement(12657..13682) /locus_tag="EFME980_RS05050" /old_locus_tag="EfmE980_0228" CDS complement(12657..13682) /locus_tag="EFME980_RS05050" /old_locus_tag="EfmE980_0228" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_002290378.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="DBD-Pfam|LacI,DBD-SUPERFAMILY|0044558" /protein_id="WP_002290378.1" /translation="MVGIRDVAKRAGVSIATVSRVLNEDPTLSVTDETKRKIAESVNFY HYVKKSPVAKNLTNIALITTVSEVDELEDPYFRTIRRGIQVEAEQSKVNLKKIIRLSET PLEQDDLLKCQGVLIIGQVLSSVIEEVSAINSNVVVIDDPSIEAEVDAVYTDLTKATNQ HLDRLYKKGHRNIAFIGGGRVRLDSQGNKHVSDDDYRKIAYETWMKQKGLEKYSQIYLE GWTTLDGMQAADLLLKKHAKDKLPTAIMVGNDPIAVGVYRSLQKNGLRIPEDISIVSFD NIEVAEFLTPALNTVNVNTEEIGKLAVRMVNERIKEVRNVSIKVIVSNNIIVRESEKNI D" ORIGIN 1 ttaaaatttt aatgcaacac tagtgaaaat ttttatatct ttagactcaa tgataaattc 61 tttcgtatcc aagttagccg ttaatgttgc actatcacta ccgtttttat ttttacgtgt 121 aatcactatt tctgattctg atggcgttgc tacttcaatc gttccatcca aatcaaacgc 181 cgcagattca tttctaaatt ttaaaagtgc aaataattgt tgaatcactg gccgttgcac 241 ttcttcttca atttcggcta aatcatagta atgacgatta atattacgcc cttctttcgt 301 tgcttccaac agttcaatat cattttttcc tgctaataac ccaacgtaat aaatttgtgg 361 aatccctggc gcaaatactt gaatcgcacg tgctaacaga tagctacggt cattatcgcc 421 taatgcacta taataggtgc tgttaatttg ataaatatct aaattattgt aattggcact 481 tgaatagacc ttcttcacat tcgccccgac tttatacaat tcctcagagg tgtaatccaa 541 ttcttcatct gttaataaat cacgagcgtc cacaacacca attccatcat gcgtatccaa 601 tgttgtaaac tgcttcatcg gactcatttt caaccaattg gctaaacgtt ctgattttcc 661 actataaagt gaatacagag tgaccattgg cgaggcgaag tcatagatat aataatcatg 721 attggcaatt ttcatttgaa tggaataatg ctcatggatt tctggtaata attcgacgtc 781 atatttcgct gcttcttgac gcacttcgtc taaaagttcc caaatatctg gttccacgaa 841 gaaatcattg gtatctaatt ttttaatcgc ataagcaaac gcatctaatc gaattaaaga 901 acagccatgg ttcgccatat ctttgatggt ttctcgaata aattctttca caacttcttt 961 ggtcacatct aaatcaattt gttcttcccc aaaggtattc caaacctctt ctgtcgtacc 1021 atccgcaaat tctaccgttt gaaacggcgc tttgtcttta cgcttgtaga ttaaatcaat 1081 atcttcttgt gttggtcgat tttctgggaa aaattcatga atacggataa acatttcttt 1141 gtatggtgac tgctcatggt tttttttgaa atcttggaaa aattttgatt cacgagaaat 1201 gtgattaatc ataaaatcaa acatcaaata ataatcttca cctaatgctt ccacatcttc 1261 ccatgttcca agagctggat caactgtcgt ataatcactc ggcgcaaagc ctcgatcacc 1321 tgtcgatgga aaaaaaggca acagatgtac accaccaata acaccttgta aatgtttgtc 1381 taagacttgt tttaattcgc ccatgttttt tcctaaacta tctgcatagg tgatgagcat 1441 tgcttcgttt ttaattttca taattgtcct ccataattag ctaatacaat actttcaaac 1501 ggtcgtaaac gcaattttcg actttgatct aataaaacat cttcataatt attgattaat 1561 acttgttggt actgttcatc tacataatat tcttgttctg ttgctgtaac gtttaagata 1621 actaatacga ttttatcttc taattggcgt tcataaagca aaatatgttc atttttatct 1681 ttcactggta gaaattgtcc gtagattagc acgtctttgt atacactatt ttttcttaat 1741 ttaattaatt gatgataata attgaatacc gactgttgat tggttaactg agcttctgca 1801 ttgagttctg gataattagg atttactttt aaccatacat tatcagaagt tgagaatctg 1861 gcattttttt gcgtattcca ttgcataggt gtgcgagaat tatcccgact tcgtttattg 1921 acagctttca atgcttgctc tggtgccaat ccatattcta atgcccgttt atactgagaa 1981 tgcgtagcta catcatcaaa atcttctaat gatgccattt ctatgttggt cattcctagt 2041 ttttgtcctt gataaataaa aggggtacct cttagtaaca taaaaagcgt cgccaacatt 2101 tttttactat aatcattgat ccattcttct ggaatatatt tattaattga acgtggttga 2161 tcgtggtttt ctaaatataa ggcgccccaa cctttatctt gcgtaactaa ttgattcgta 2221 aaaatattgg tacgcatatc cgtccatgtc cattggctat ctttaaacca ttcaccagtt 2281 tcaggtacat caatatccgt ataactaaaa tcaaaaacca tcgaataata gccatcttca 2341 ccaatatatt catctaaacg ttcattagga acatcggctt ctgctaccgt catactatta 2401 tgtggtttaa atgtccgctc tctcatttct tttaaccaca cttcaatgcc cgactgatta 2461 agaatccagg gcccaatgaa ggctaaccca tcttctccat cagattcaaa gatgccatac 2521 tctagttttt tttgatgttt aatatcgcat cgattctaaa tccgcctagt cctttatcta 2581 accaatagtt aatcattgca tagatttctt cacgtacttc ttcattttcc caattcaaat 2641 caggctgctt tttagtaaat gcgtgtaaat aaaacatatt ttcttcgttt ggaatgagtc 2701 tcttttggtg ttgcacttat attgtaaatt caagctacta tatctgtttc aaataaaagc 2761 gttgtgtcgc ataatcacca tgtagttctg agtcaatata aaaaccgaga ttcatcaatt 2821 catcgccagc aaatgttaca tcttccattt gataagttgc ttcttctgct aatcctgcta 2881 atttcaatgt gactaatgga tgcgcagctt ctgctaatac tcggaaataa aagaccatgg 2941 cttctgtttg gtcttttgag acaaacatcc atgcagtatc attgccttca aacggacttt 3001 ccaagcgata aaaagttcca tattgcaaaa gttggcgatg ctttttataa aaggcaactt 3061 gttctttaat ttctgctttt tcttcagaag ttaattgcgt tagatctagc tcataaccaa 3121 aaacaccagc catcgcagca ttgccacgaa tagttaaact cgtttctctt cctgtttgat 3181 gatttgggac tgctgaaaca tgcgcaccca tacttgaaat tggatacact aagctggttc 3241 catattgaat tttcagacga gccacggcat cggtattgtc gctcgtccaa gtttgtggca 3301 tgtaatacaa gaaacctgca tcaaaacgac cgcctccacc cgaacaactt tcaaataaaa 3361 tagttggata attcgttgtt aacttttcta aaaattcata taaccctaac atataacgat 3421 gagccacttc accttgcatc gttgagtcca acaagacaga atagacttct gtcatatttc 3481 gattcatatc ccacttcaca taatcaatcg gtacacgatc aaaaatcgcc gtcatttgtt 3541 gatagatatt atcacgaaca tcttgtcttg aaaaatcaag aacatattga tttcgactaa 3601 ttgagcggtc acgacctgga atacccaatg cccaatctgg atgtgctcga aatagttcac 3661 tatcttcaga aatcatttcc ggttcaaacc aaatcccaaa tttcatcccg ttatcatgca 3721 cttgcttggc taaattttcc aaaccacaag caagtttgcc ttctgtttca acccaatcac 3781 ctaatgaagt gaagtcattt tcacgaccgc caaaccaacc atcatctaaa acaaacattt 3841 caatgcccaa gttcttcgca tcatcgacaa tattcatgat tttttcttcg ttaaaatcaa 3901 aatacgttgc ttcccagttg ttgattaacg tgggacgttc ttttaaacga tagtttccac 3961 gaattaaacg gtgattatac aattcatgat acgtctgtga taacgtattc agaccttcat 4021 tactataaac catcacgact tctggcgttt gaaatgagtc gccagttttt agttgccaac 4081 caaaattaaa tgaattaatt cccataatga cccgtgtttg gtcaaatgga tctttttgaa 4141 tcaccgtttc gtgattaccg ctataaacta aattaaatcc atatgcctct ccttgaaatt 4201 catctgtttt ggcatctact aaagcaacaa acggattttg ttgatggctg cttgatccgc 4261 gtttactatc taatactttt atccctgtat gaattttttc tctagtcatt tgacgttctc 4321 ttgcccaggt accatttaaa tgaattaact cgagtggacg atttggaaaa tcaattgatt 4381 gactagctaa gcggttaatc tccactgttt catcactatt atttactaat tgcgtagaac 4441 gaataattac actgtgattt tgataaattg tgtagaacaa ctgtaaagtc aatccactaa 4501 tcgcgtcttt caattgaata atcagcgttt cagcttcatc atcatcttcc gtatataagg 4561 ctggcaatcc cgctaagctg ggctttcctt tttgaatttc gtagctatca taacgaaaat 4621 catttacacg actaccgttt cctaatttaa tattatgcgc cggttctcta aaatcaccat 4681 gtccatatcc tggaaattct aatggtaatg tatctaaaga taataaacga tcttgcgcat 4741 ttgcattgtt gggtgagaag gaacgatctg ttcgggggta gcgataccca ccagaatagt 4801 gcgtaatctt ttttccaaaa taaagatgcg ttaaataatt attttcttcg attcctaata 4861 gatagctaat ttttttattt tgtaaatgaa atgtttgtgt gtgattgtca aatataatca 4921 taagtttatg aactccttta taatgagaat aatttattgg ttatttcact gctccattgc 4981 tcattccagc tataatactt ctttggaaag caagataaac tagtgtaatc gtgacaattc 5041 ctactgtata ggaagcaaaa cttggaccat agtcgttaaa atattgtccc gtataattat 5101 attgaaacaa tggtagtgtc cacatattag aatcacgatt taaaattaat aatggtagca 5161 tgaaatcatt ccaaaaccat agtgcattaa gaataatagt cgtcgcatgc attggtttta 5221 acattgggaa aacaattttg aaataagttg taaagtgact agccccatca atttcagcag 5281 cctcatccag actgataggc acatttagtt taataaaacc aacatataaa aatagtgtct 5341 gtggtacggc ataagtgaga tagagtaaga ttaatcccca catatttgct aaaccaattt 5401 tactcatcat aacggtaatc ggaatcataa ttacttggaa aggaacaaaa attcctaaaa 5461 ttaaaaataa atacatcaat ccgtatgctt tcccacgagt catttttctt gctagtgaat 5521 aagcagccat aggaataatt gctgtcacag caactactgc aatgattgtg atgattgccg 5581 aattccaaaa gtaatgacca attccatccg ctaacaatct tcggaaattt tccaaagtcg 5641 ctggattagg aaaacgaaag aaattattca taatatcggg tgttgtttta aatgaaccga 5701 atagcgttga aactaaggga actaaaatca tgaagccccc taataataaa agcaagtatt 5761 tagaaatatt tttttctttt gatgttttca ttgggaaacc tcctagattt caaatttttt 5821 cgataatttt aattgtgcca gtgaaacaat cccaattaag ataaataaga ctaaagcaat 5881 agcattcgca taaccaaact gattgttttt aaaagcataa ttataaacaa gtaaccccaa 5941 agatgttgtg gcatcgcttg gtccaccacc agttaaagca aaaatttgat caaatgctgt 6001 taagccacct tttaatgcca taataaatac cattgaaata cttggtaata agtaggtgat 6061 ttcaatattc caaaaaattt gcttatcatt cgccccatcc attctagcag cttcaataat 6121 ttcttgtgga atactttgaa aacccgctaa gaaaatgatg actggcatgg caattccttg 6181 ccaaagtaaa acaaaaatta ctgcaaaaat cgctccccat gttgttccta aaagactggt 6241 ttgtaaaaat tcaatgccta acatactacc aatttttggt aaaccatagt taaaaatttg 6301 tttaaatact aaagaaacaa ccacgcccga taagaccgct ggaaaaaaga accatgctct 6361 aaagaatgtt ttccctttaa tatttgcgtt caacgcccgc gcaatcaaaa taccaaaacc 6421 aatttgtcca gcaatcatgc aaagcgtcac aattaaagtg aagccaatcg atttgataaa 6481 cttcggatca gaaaaaagaa tcttataatt gttcaaaccc acaaaatcaa aattataagt 6541 cagaccagtc caattagtta aactgtaaaa agcaccttga accattggaa agtagaaaaa 6601 aatcatctgc aaaataattg gaattgctac aaaaatgatt gcccagtaac gatttaaaat 6661 ttcttttatt ttcattttat tttcctacct tccgtcagct ttcattggat taaagaaagc 6721 atttaatgcg ttaatcatgg ctttttgatt gccattgtgt aaataatttg ttgttaaggt 6781 ataaaaatca ttttcactat tccaatcttt ggctaaccaa actaaatgac gatcagtaaa 6841 agcaagttca gttaaaccac ttaatggtga atcctgagta ttctcgataa cgccctcaac 6901 agcacacggt gcaccatcta catcataata tttctgcatc gcttcaggtg ttgtcatata 6961 ttctacaaaa cgtttggctt cttctttatg ttgagaagtt gcagaaactg ataaggctag 7021 gtctcctgcg ccaatcgtta gactttgacc tgcttcatct gctggaaaag gaaaagttcc 7081 tacttcaaaa tctggatttt gtgaatgaat catcggcatt gcccatgaac cattcggcat 7141 aatcaacgca tcaccttttg taaaagtaac tactgtatcg ttataaccgg caccttgcca 7201 gttgttttgc aaagcttttg gttctcttaa caaatctaat cgattaaaat ctttttgcat 7261 ttctttgctt tcagcattaa ttccattaac ttctgagaaa cgccaaacat tgttcgcttc 7321 ctcttcacca ccagcagcag tcgctatagc tagttggtga taaccattta aagtccagcc 7381 ttctgctcct gcaatcgcaa acggtacttt gttttgatct ttaatctcag ctactatttt 7441 ttcaaattct gcccaagttt ctggtgcttg aatccccatt tcctcaaaag cagttttgtt 7501 atagtaaaaa ccatagacat tagcggttaa tggtatgcta tatacacgat cctcaatagc 7561 aaaacgttgt gcatatccat ttttgatatt ctctaaatac ggttcttcgg ttaagtcctc 7621 taaataacca gctttcgccc attctttcaa ttctatactt tgaggataaa gattaatgac 7681 atctggtaca tcgcctgcaa gcatacgtgt tttaattact tcaccagcat tcggtacatc 7741 cacaactttt acatgaatat cagggttttt tgcttcaaaa tctttagcaa tctcctgaat 7801 cgtttgagtc atttcttttt tttgattaaa aaactctatt tctaccttac cgcttgcatc 7861 ttcctgattt tttccacaag cagtcaaaga gatcgttgct cctagtgcta tacaagctaa 7921 aatgattttt ttagaccact tcattttatg ctcctcctta tacaatttga atgcgttttc 7981 ttttttgtta acactaatgt aactgtttac taagtgtttt gtcaatattt ttactaaatt 8041 taactaagaa aagagtaagg aattgaaaat tccttactct ttcagcttct ttttaattat 8101 attcaggtaa atagtcccca tgtgcttcga ttaaatcatc cactaaattt ttgatatctg 8161 ttaaagacaa ttcagatgat agatgtggat ctaaatacgc tgcttgataa atttttgatt 8221 tatctagtgt taaagcggct tctactgtca gttcttgaac attgatattc gtccgattta 8281 aagcagctaa ttgtgttggc aattcaccga cataggttgg ttgcacgcca tttttatcga 8341 ctaaacaagg tacttccaca caaacatctg tcggtaagtt tgtgattaag cctttattta 8401 agacatttcc tgcaatcact gacggagttc ctgtcgtaat agaatccatg atatatgaag 8461 catattcacg gcttctcgta tgtgttaact ccccattatt tacaatgtcc tctcgcatgc 8521 tttcccaatc attaatttgt tgttcacaac gacgtaagta ttcatccaac ggaatcccta 8581 attcgtcaat caattctggg tattttgatt taataaagta tggatggtat tctgcattgt 8641 attcacttga ttctgtaata tagtaaccaa aacgtttcaa caattcaaaa cgtacagaat 8701 ctggatgtgg atttggtttt tctgcagcta actgacgaat tgttggatag aaatcttccc 8761 cattttttgt aatttccaac aagaatgcca tatgattaat gcctgcaatt ttccattgaa 8821 agtcatttaa gtcatattgg tcggctattc ctaaatgctc aaacaattct ggtacgcata 8881 cttgaacgct atgacataaa ccaacagtct taatactcgt cgcttttaaa acacccatgg 8941 ttaacatcgc catcggattt gtatagttca ataaccaagc atttggacaa acttcttcca 9001 tttctttagc aaagtctaac attactggta gtgtccgtag ggttctaaaa atcccaccaa 9061 tccccatggt gtcaccaata gtttgtcgca acccatattt tttaggaata tcaaaatcaa 9121 tcactgttga aggtttataa ccacccactt gaatagcatt gataacaaaa tcagcctctc 9181 ttaacgcttc tttgcgatca taataagaaa caatatcagc acgattttca ttcgaatttt 9241 tattaatatt tttaagcatt aaatttgatt cttttagtcg tttttcatca atatcgtaca 9301 atgcaatatg tgcatcttgt agacttggag ttaacatcgc atcgcctaat acgttttttg 9361 caaaaatagt acttcctgca ccaataaatg taatttttgt catgtactta ctctccaatc 9421 actaattaat agttttataa tttaccacct gttgtagcaa ttccttcaat gaattttctt 9481 tggaaaacga tgaatatcac aactattggc caaattgcta ataacgaacc tgccattaat 9541 tgtgggaagt tcgtggcata ttgtccttgt aagtttgcta atcccggagc taaaggcatc 9601 ttatcaattg aagtattgac aatcaatggc cacattaaat ctttaaatgc aaacaacgct 9661 gtgaatattc caagtgcaac caatcctgat ttagcaagcg gcaacataat tttgaaaaag 9721 atcgtccaaa tattggcacc ttctaaatag gccgcttcct ccaattcatc aggtaaacct 9781 aagaaaaatt gtcttaataa aaacgtacca aacgcactaa ctacccctgg taatattaat 9841 gctggaattg tatttaaaat acccaatttt tgtgctaata aatactgtgg agtaataaaa 9901 atggaaccgg gaatcatcat ttgaataagt actaagctga aaaggatatt tttccctgga 9961 aaacttagac gcgcacaagc atatgcagcc attgctgaaa ataaaaccga gccaatcact 10021 cgtccaacaa ccattaaaaa tgtattgata taaaaagcca tgaatggtaa taaatcaagt 10081 acttgttgat agttacttag ctgaaatttc tcagggaaaa ttgtaggtgg aatttgggta 10141 gattcaacca acgttttccc tgaagttaaa atcatccaaa taaaaggtaa tgccattgca 10201 ataccaccta aaataagcat gatatggatt ggcgcatttg aaaaaaattt atttttcata 10261 atttgatagc ctccttaata gtttacccac tttttctgca acttcatttg aattgcagta 10321 ataattaata taatcactaa aaggaacata acgattgccg aaccatatcc cttgtcattt 10381 aaaataaatg aatgtttata gaataaatag gctaatgatt gtgatttaaa catggcggta 10441 ctattaggag taatcatcat aaaaataaca tcaaatactt ggaaagcatt gataactgtt 10501 gttacaacta caaaaaataa tgttggtgta actaatggta acgtaatgtt gaaaaactgc 10561 tggattggac tagcaccatc aatttccgct gcttcataat aatctttagg aatttcttat 10621 aagccggcta gtaataacac catgttataa ccaatagcac tccaaactcc tacaatgata 10681 atagaataaa tcgcaatcga tggatccgtt aaccatgctg gtccatcgag acctatttta 10741 gccaacatgt tattaatcag tccataatca ttattgaaca tccagcgcca aatcattgcg 10801 actgcggatg gtgcagcaac gactggtaga aaataaattg tccgataaat cgacaatcct 10861 ttaacttttc tattcattaa aactgccacc aacaaggata atacaacaat actaggtatc 10921 gaaaccactg cataaattaa tgtgtttaat aaagactgaa aaacttcacc gtctgcaaac 10981 attttttggt aatttcttaa tccgacccat tcagtatcac cgaaccctac cgttttttga 11041 aaacttaaaa ttgctgtttg aattgctggc catatattta ataaaattaa tcctaatgcc 11101 gttggaaaaa taaaaatata gccccatatc acttgatctt tacgatattt tccaaaaatt 11161 cgatttttca taatatcccc ctttttggta ttcatccatt aatataaaga cgaaatagaa 11221 tcctttcgcc tgtatattgt ataattaact aatttaattt ccgctcaata tcgcattgac 11281 ttctttttca atttgagcgg ttccatcttc aacagttact tcaccagaca gaatacggtt 11341 aataatttga acttctgctt gttcagctcg taatccatct ttattgtatg gacgagggac 11401 tccatactcc aacatttttc caaaagtact caaatcaatt gtatctgaag aagcagccca 11461 ctcgtcttca aagcctttta gtgctgggat tgatgccccc gtttccgctt ggattttatt 11521 ggcgtcctca ctagctaaaa atgccattag ttttttcact tcttctgggt attttgtatt 11581 cgcactggca gcccaaccaa gtccatttgt aattgttgca ttaacttttc ccttaggtaa 11641 cacggcagaa gcaacatttt caactagata gtcatttttc aaaaatcccg gtgcaaacca 11701 gtttccttca atcatcattg ctaatctacc tgattgaaaa cgacttaact tatcaggatc 11761 ttgtaattct gtaattgttg gtgaagcatg atcaacaagt gcaatatctc gataaaaagc 11821 taaagcttct tgtgcttctg gggtattcaa acctgatttt gtattgtcat cggcaaatac 11881 ttctccccca ttttgataaa taaatggcca gtagccagtc tctgttccaa tatgtgatgc 11941 aaaaccatag atgccttttg attcatctgt taaatcaatt gcagcttgtc tgagtgtttc 12001 ccatgtccat gtttcatctg gataatcgac acctgcatta tcaaataatt ctttgttgta 12061 ccatagcccc actacagaag catctttagg gattgcgtat agttcgtctt caagcgtata 12121 gaaatcagca attccttcag taaagtttcc catgtcaata tcattttctt tgataacatc 12181 atcaagtccc atcaaagcat tctgtgacat atatttatag gattcgctag agtgcatggt 12241 tactacatct ggcatattac ctcccgttgt tgcagcttct aatttaaccc aatattgatc 12301 ccaaggcgtt gtctccattt ctactttgat atcaggattt tgtttttcaa attcatctaa 12361 catttttctt agtcctggag cttggtcagt atctcaactc gcatagctta aagttacttg 12421 cccgtcttta gaattactat ctcccccacc acatgctgcg agtaatgtcc cagttaaaac 12481 agctatccct gttaaagcta tttttttgaa atgtttcatc ttaattcctc ctgttttgaa 12541 tgcgttttct ttttgttaac aacaccataa ctgtttactt aatgttttgt cgagattttt 12601 tactaaaaat attagtaaac aaaaaagtaa acaccctttt ttggatgttt acttttttaa 12661 tcgatatttt tttcactttc tctaacaata atattattag aaacaatcac tttgatcgaa 12721 acatttctaa cttcttttat tcgttcatta accatgcgaa ctgctagttt tccaatttct 12781 tctgtattca cattcaccgt atttaatgca ggtgttaaaa attcagcaac ttcaatatta 12841 tcaaaactca caatcgaaat atcttctgga atacgtagac catttttttg aagtgaacga 12901 taaaccccca cagcaatagg atcatttcct accatgatag cagtcggcaa cttatcttta 12961 gcatgttttt tcaaaagtaa atctgctgcc tgcattccgt caagtgtggt ccagccttct 13021 aaataaattt gactatattt ttctaatcct ttttgtttca tccacgtctc ataggctatt 13081 tttcgataat catcatctga cacgtgttta tttccttggc tatctaaacg aacacgtcct 13141 cctccgataa acgcaatgtt tcggtgtcct tttttataca atcgatctaa atgctgattc 13201 gttgcttttg ttaaatcagt ataaactgca tctacttcag cttcaatact agggtcatca 13261 atcactacga cattcgaatt aattgctgat acttcttcaa tcacagaaga tagcacctgc 13321 ccaataatca acacaccttg acattttagc aaatcgtctt gctccaacgg tgtttctgac 13381 aaacgaataa ttttcttcaa attgactttg ctttgttctg cttcgacttg aatccctctg 13441 cgaatcgttc gaaaataggg atcttccaac tcatctactt cagaaactgt cgttattaat 13501 gcaatatttg ttaaattttt tgcaacggga ctttttttga cataatgata aaaattaacc 13561 gattctgcaa tctttcgttt ggtttcatcg gttactgaaa gtgtcggatc ctcatttagc 13621 acgcgcgata ctgttgcaat ggacacaccc gcccgttttg caacatccct aattcctacc 13681 at //