LOCUS CR931683 21475 bp DNA linear BCT 26-JUL-2016 DEFINITION Streptococcus pneumoniae strain 1196/45 (serotype 23a). ACCESSION CR931683 VERSION CR931683.1 KEYWORDS . SOURCE Streptococcus pneumoniae ORGANISM Streptococcus pneumoniae Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. REFERENCE 1 (bases 1 to 21475) AUTHORS Bentley,S.D., Aanensen,D.M., Mavroidi,A., Saunders,D., Rabbinowitsch,E., Collins,M., Donohoe,K., Harris,D., Murphy,L., Quail,M.A., Samuel,G., Skovsted,I.C., Kaltoft,M.S., Barrell,B., Reeves,P.R., Parkhill,J. and Spratt,B.G. TITLE Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes JOURNAL PLoS Genet. 2 (3), E31 (2006) PUBMED 16532061 REFERENCE 2 (bases 1 to 21475) AUTHORS Bentley,S.D. TITLE Direct Submission JOURNAL Submitted (09-DEC-2004) Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail: sdb@sanger.ac.uk COMMENT NOTE: This sequence was generated from a PCR product representing the region from dexB to aliA and is not necessarily responsible for the expressed capsule serotype. For a detailed description of how CDS products were predicted see the associated publication. FEATURES Location/Qualifiers source 1..21475 /organism="Streptococcus pneumoniae" /mol_type="genomic DNA" /strain="1196/45" /db_xref="taxon:1313" gene 1204..2649 /gene="wzg" /locus_tag="SPC23A_0004" CDS 1204..2649 /gene="wzg" /locus_tag="SPC23A_0004" /note="member of homology group 0" /codon_start=1 /transl_table=11 /product="integral membrane regulatory protein Wzg" /protein_id="CAI33811.1" /db_xref="GOA:Q4K0K5" /db_xref="InterPro:IPR004190" /db_xref="InterPro:IPR004474" /db_xref="UniProtKB/TrEMBL:Q4K0K5" /translation="MSRRFKKSGSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFR YLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLN ATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVNQ SSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSK NQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNQK DKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKLIDLLGGIDVYNDQEFTAHT NGKYYPAGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNYS TIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSYAMPDSNLY VMEIDDSSLAVVKAAIQDVMEGR" misc_feature 1204..1320 /gene="wzg" /locus_tag="SPC23A_0004" /note="Signal peptide predicted for SPC1162 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.538 between residues 39 and 40" misc_feature 1408..1755 /gene="wzg" /locus_tag="SPC23A_0004" /note="HMMPfam hit to PF02916, DNA polymerase processivity factor, score 1.6e-64" misc_feature 1933..2376 /gene="wzg" /locus_tag="SPC23A_0004" /note="HMMPfam hit to PF03816, Cell envelope-related transcriptional a, score 2.5e-69" gene 2651..3382 /gene="wzh" /locus_tag="SPC23A_0005" CDS 2651..3382 /gene="wzh" /locus_tag="SPC23A_0005" /EC_number="3.1.3.48" /note="member of homology group 1" /codon_start=1 /transl_table=11 /product="protein-tyrosine phosphatase Wzh" /protein_id="CAI33812.1" /db_xref="GOA:Q4K0K4" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR016667" /db_xref="UniProtKB/TrEMBL:Q4K0K4" /translation="MIDIHSHIVFDVDDGPKSREESKALLTESYRQGVRTIVSTSHRRK GMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDSRY ALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNGKRVRELIDMGCYTQIN SYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIAKKYG AKKAKELFVDNPRKIIMDQLI" misc_feature 2654..3262 /gene="wzh" /locus_tag="SPC23A_0005" /note="HMMPfam hit to PF02811, PHP domain, score 4.9e-37" gene 3391..4083 /gene="wzd" /locus_tag="SPC23A_0006" CDS 3391..4083 /gene="wzd" /locus_tag="SPC23A_0006" /note="member of homology group 2" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q93E03|8.A.3.2.3" /protein_id="CAI33813.1" /db_xref="GOA:Q4K0K3" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR005701" /db_xref="UniProtKB/TrEMBL:Q4K0K3" /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFTYSTFVIK PEFTSTTRIYVVNRNQGEKSGLTNQDLQAGTYLVKDYREIILSQDVLEEVVSDLKLDLT PKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVTTLE EARPAISPSSPNIKRNILIGFLAGVIGTSVIVLLLELLDTRVKRPEDIEDTLQMTLLGV VPNLNKLK" misc_feature 3409..3825 /gene="wzd" /locus_tag="SPC23A_0006" /note="HMMPfam hit to PF02706, Chain length determinant protein, score 1.9e-52" misc_feature 3931..4008 /gene="wzd" /locus_tag="SPC23A_0006" /note="PS00217 Sugar transport proteins signature 2." gene 4093..4776 /gene="wze" /locus_tag="SPC23A_0007" CDS 4093..4776 /gene="wze" /locus_tag="SPC23A_0007" /EC_number="2.7.10.1" /note="member of homology group 3" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q93NW3|8.A.3.2.2" /protein_id="CAI33814.1" /db_xref="GOA:Q4K0K2" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR005702" /db_xref="UniProtKB/TrEMBL:Q4K0K2" /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVSP GEGKTTTSVNIAWSFARAGYKTLLIDGDTRNSVISGFFKSREKITGLTEFLSGTADLSH GLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVIDAA IITQKCDASILVTATGEANKRDVQKAKQQLKQTGKLFLGVVLNKLDISVDKYGVYGFYG NYGKK" gene 4792..6159 /gene="wchA" /locus_tag="SPC23A_0008" CDS 4792..6159 /gene="wchA" /locus_tag="SPC23A_0008" /note="member of homology group 5" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|H8E4X1|9.B.18.1.2" /protein_id="CAI33815.1" /db_xref="GOA:Q4K0K1" /db_xref="InterPro:IPR003362" /db_xref="InterPro:IPR017475" /db_xref="UniProtKB/TrEMBL:Q4K0K1" /translation="MDEKGLKIFMAVLQSIIVILLVYFLSFVRETELERSSMVILYLLH FFVFYVSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYFLT LEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWKLVAV SVLNKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMGIDVT VNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVISKRILDICGATIGLILFAIAS LVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTMQGGMFK IDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPEQKRRLSF KPGITGLWQVSGRSKITDFDDVVKLDVSYIDNWTIWKDIEILLKTVKVVFMRDGAK" misc_feature 5575..6156 /gene="wchA" /locus_tag="SPC23A_0008" /note="HMMPfam hit to PF02397, Bacterial sugar transferase, score 4.9e-146" gene 6190..7368 /gene="wchF" /locus_tag="SPC23A_0009" CDS 6190..7368 /gene="wchF" /locus_tag="SPC23A_0009" /note="member of homology group 15" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="CAI33816.1" /db_xref="GOA:Q4K0K0" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015393" /db_xref="UniProtKB/TrEMBL:Q4K0K0" /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMRE NSAKSGTTEDVFEHNGAICYNVDVPNIGPARAIVYDIAAINRAIEIAKENKDEDPIFYI LACRIGPFIHGIKKKIQAIGGTLLVNPDGHEWLRAKWSTPVRRYWKISEGLMVKHADLL VCDSKNIEQYIQEDYKQFQPKTTYIAYGTDTTRSILKSSDEKVRSWFKEKNVSENEYYL VVGRFVPENNYESMILGFLASNSKKDFVLITNVEQNKFYNQLLAKTGFDKDPRVKFVGT VYNQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVAEDGADYW EKDNLHKVIEASEQKTQEEINEKNILSTKQVTERFSWDLIVNEYEKLFTRKN" misc_feature 6805..7302 /gene="wchF" /locus_tag="SPC23A_0009" /note="HMMPfam hit to PF00534, Glycosyl transferases group, score 0.0028" gene 7578..8984 /gene="wzy" /locus_tag="SPC23A_0010" CDS 7578..8984 /gene="wzy" /locus_tag="SPC23A_0010" /note="member of homology group 243" /codon_start=1 /transl_table=11 /product="oligosaccharide repeat unit polymerase Wzy" /protein_id="CAI33817.1" /db_xref="UniProtKB/TrEMBL:Q4K0J9" /translation="MRYGIMRISFSKKTMLCGLLYIGLILSVVTIPTIVTFLYSLLFIG IVTVLNYNSILASDEDANSFFVALPIILSSFQNVYLGFGADRLNSVTLQVLLSISIAII TITVFLGIILNRFKSKEFSWLVLSILVIIIQSVILLIFFPTTLPAYLSSMRNILAPLLI FYFSIYGFKNINLQKFYKYMFIIILVVLIFGFIEYIYGNSLWTRLNIKKLWALKGLAIE NRVVPGNWHSSELIGGKQLRRMVSTFADPVNLGSYLFAAFMLAWYKNKKLLQVLLLASF VLSVSKAAFLSMLVYIIIYTWVVDKNKILSIFGIIISTVLGLYFYNFSQVSSYGSINAH IDGFFSALSTPLHYPFGMGVGSVGVLASKLGSQTALSSEVLETGIGMIIAQLGFVGVII YLIFFVKLSVIGKNINNKRDKILWFTLIYSFLANAFFNEVALSPNSCTLYFLILGLLYN KNKIRSTEFS" misc_feature 7578..7748 /gene="wzy" /locus_tag="SPC23A_0010" /note="Signal peptide predicted for SPC1168 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.336 between residues 57 and 58" gene 8984..9955 /gene="wchV" /locus_tag="SPC23A_0011" CDS 8984..9955 /gene="wchV" /locus_tag="SPC23A_0011" /note="member of homology group 109" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|P75905|4.D.1.1.3" /protein_id="CAI33818.1" /db_xref="GOA:Q4K0J8" /db_xref="InterPro:IPR001173" /db_xref="UniProtKB/TrEMBL:Q4K0J8" /translation="MEKLVSIILPVYNVEQYIKNCLESIQQQTYPNLEVIIVNDGSTDK SVEYCEQICKIDSRFSITHKENGGLSDARNVGIDKAKGDYLIFVDSDDFVSQDMVSYLV SCMENNEADIAICDPVHYYSDRQNNDLNIFSPASSVKVYETTEALCEMFYQKSFLVSAW AKIFKRELFDDIRFPVGKLFEDSAIMYLLLEKCETIAYSDAKLYAYVHRDNSITTKKFS DRDLDILEITNTIINHYGDNLRVYTAAVSYKVSACFRILLNSPSEEKYKKVQKECLSYI LQNWRNILFNNNVRLKNKLALISITIFNPFVKLIYSKVNRWE" misc_feature 8999..9511 /gene="wchV" /locus_tag="SPC23A_0011" /note="HMMPfam hit to PF00535, Glycosyl transferase family, score 1e-49" gene 9962..11194 /gene="wchW" /locus_tag="SPC23A_0012" CDS 9962..11194 /gene="wchW" /locus_tag="SPC23A_0012" /note="member of homology group 110" /codon_start=1 /transl_table=11 /product="putative transferase" /protein_id="CAI33819.1" /db_xref="GOA:Q9R924" /db_xref="UniProtKB/TrEMBL:Q9R924" /translation="MNKYEERYQENLSKNDFYKLINKSYLSDKELQVQQVKAGIVLPPK AFETKLSNKLGLQKSLHGKGGVVDSNGNYIELSAQKAVGMRNRVYGPYKINYDNLPIRN EKVIYLNYFIKQWGHFLLDVVGRLWYPLLQDNDTKLVYTCYAGTETKIEGNYLEFLKLL GIDQSRLIMINCPTQFSEVIIPESSILPGGYYTKEYKQLFSSVVENIKLDKYDVNAKMI YCSRSKLGIAKSKEFGEDGIEGIFKQNGYTSVYMETMSLEEQIKTLLSAKTIVLTSGSL AHNLLFVNKDIDVFILNKTYRVNLHQFLINEISDATVRFVDIYRSPLPILYGYGPFLMD LTKPLANFLDDNEFVYEKGTVLSKKDYFKYYLKWLWSYRFFLFRLNGIKEGNSEFEKSF KIIRRYYKTGR" gene 11196..12581 /gene="wzx" /locus_tag="SPC23A_0013" CDS 11196..12581 /gene="wzx" /locus_tag="SPC23A_0013" /note="member of homology group 111" /codon_start=1 /transl_table=11 /product="flippase Wzx" /protein_id="CAI33820.1" /db_xref="GOA:Q4K0J6" /db_xref="InterPro:IPR002797" /db_xref="UniProtKB/TrEMBL:Q4K0J6" /translation="MSKYKELAKNTGIFALANFSSKILIFLLVPIYTRVLTTTEYGFYD LVYTTIQLFVPILTLNISEAVMRFLMKDGVSKKSVFSIAVLDIFIGSIAFALLLLVNNL FSLSDLISQYSIYIFVIFVFYTLNNFLIQFSKGIDKIGVTAISGVISTAVMLAMNVILL VVFDWGLLGFFIANVCGYVIPCIYIVSRLRLWELFEIKIDKKLQWEMVYYALPLVLNIL SWWVNNTSDRYIVTAIVGIQASAIISVAYKIPQILSTISAIFIQSWQISAIKIQEDKSG TTFVSNMLLYYNALLLIIASGIILFVKPISNILFGISFYSAWELVPFLIISSLFNAISG CIGAIMGAKMDTHNIAKSALVGMIANIILNIVLTFLMGPQGITISTLIASFLIFYMRKD SVKEINSETYRAIYLSWILLVVEACLLIYMDFIIGALIAMVINLFLLKDVIKPLYLKIF KRN" misc_feature 11214..12023 /gene="wzx" /locus_tag="SPC23A_0013" /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 6.3e-67" gene 12589..13737 /gene="wchX" /locus_tag="SPC23A_0014" CDS 12589..13737 /gene="wchX" /locus_tag="SPC23A_0014" /note="member of homology group 53" /codon_start=1 /transl_table=11 /product="putative glycerol phosphotransferase" /protein_id="CAI33821.1" /db_xref="GOA:Q9R922" /db_xref="InterPro:IPR007554" /db_xref="UniProtKB/TrEMBL:Q9R922" /translation="MIVLQYFKILARFVFMFLISAVLLPFKIKPNKIVFINFNGKGYGD NPKSICEYLRTTYPDLDLVWLARDNEGFPDGVRVVKYGTFQAFYEQASSKVWVYNVRAF ARILKKRGQIYIQTWHGASSFKLIEKQADLPINYVLEAKYDARVTDIMISDSRKQTEEF QKYFWYSGEIFEVGMPRNDALFHYKEDYDKLNNIRKELSIHSDDYVILYAPTFRDDGDA SYLDINFERLLQCVEHGIKKKCKFLIRLHPNHSHLCNNISFNKNIINATFYSDMQELTL LADVLVTDYSSSIFDFMLLNKPYVRYVNDLEKYAELRGVSDTYYELPDSIIKTAEELYD LLPKKIENFDYDSIKKYRNEILCPIFNGTASENVGRRIIQEL" misc_feature 13177..13728 /gene="wchX" /locus_tag="SPC23A_0014" /note="HMMPfam hit to PF04464, CDP-Glycerol:Poly(glycerophosphate) gl, score 4.3e-73" gene 13773..14801 /gene="gtp1" /locus_tag="SPC23A_0015" CDS 13773..14801 /gene="gtp1" /locus_tag="SPC23A_0015" /note="member of homology group 40" /codon_start=1 /transl_table=11 /product="putative glycerol-2-phosphate dehydrogenase" /protein_id="CAI33822.1" /db_xref="GOA:Q9R921" /db_xref="InterPro:IPR002658" /db_xref="InterPro:IPR016205" /db_xref="UniProtKB/TrEMBL:Q9R921" /translation="MKNNDLKIGSGAIHQISATLSQNSISGKILYCADPVVDDLYGSIV RSQIEEIGRVKEESCNYNTIAYAMNIAERAIATDIDCIVGMGGGRVLDVCKYASFISKR PYLSIPTTAANDGIASPVAVLKRQDDRPKSLGAAIPSMTLIDIDVIASGPIQNIKAGIG DTISNYTALKDWELAVERGKDEMHGFAYLMSQNSLDALMKTKYNSITPDFIEVLVNSLV LSGIAMDFAGSSRPVSGSEHLFSHALDYYGSTRNLHGIQVALGTVAVLKLIENSVDTVV DYLQRFEVHINPKLLGIDEELFIYCMQHATKMRSNRYTYLHEVDLSTDRLKQIYKELIS EL" misc_feature 13794..14714 /gene="gtp1" /locus_tag="SPC23A_0015" /note="HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 2.9e-70" gene 14817..15521 /gene="gtp2" /locus_tag="SPC23A_0016" CDS 14817..15521 /gene="gtp2" /locus_tag="SPC23A_0016" /note="member of homology group 41" /codon_start=1 /transl_table=11 /product="putative nucleotidyl transferase" /protein_id="CAI33823.1" /db_xref="GOA:O85005" /db_xref="InterPro:IPR005835" /db_xref="UniProtKB/TrEMBL:O85005" /translation="MKALILAAGLGTRLAPITNEVPKSLVPVNGKPILMKQIENLYQNN ITDITIIAGYKSSVLTDAVTEKYPEINIIDNVDFKTTNNMYSAYLGKAAMGDSDFLMMN ADVFYDASVIKSLLLHKAPNAIVTDLGIYIEESMKVVEKNGRLVEISKQISPEETLGAS IDVYKFSYEAGARFFEKCKEFIEDKRELQMWSEVALNAILSEVEFVACPLEGRWLEIDN HEDLVAAEKLFA" misc_feature 14820..15518 /gene="gtp2" /locus_tag="SPC23A_0016" /note="HMMPfam hit to PF00483, Nucleotidyl transferase, score 1e-07" gene 15536..16369 /gene="gtp3" /locus_tag="SPC23A_0017" CDS 15536..16369 /gene="gtp3" /locus_tag="SPC23A_0017" /note="member of homology group 42" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="CAI33824.1" /db_xref="GOA:Q4K0F2" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006357" /db_xref="UniProtKB/TrEMBL:Q4K0F2" /translation="MKLTNRVDYFGADISELQNKKLFLFDMDGTIYEEDRLFEGTLELL DYIHNIGGEYIFITNNSSKSVVDYVEKVNRLGIKAERDNFFTSAQATIVYIKENYPKSK VYCQGTKSLIKELSDAGIDVTEQVSADIDVVLVGFDTELTSDKIRNTCEILSTKDVPFI ATNPDIRCPVSFGFIPDCGSICDMISKSVDRKPVYIGKPEPTMVDIVRKKLNYSLFETV VIGDRLYTDIMTGINAGVTSVCVLTGEATVNDIQQDSIKPTYTFKNVKEMWKGIV" misc_feature 15593..16279 /gene="gtp3" /locus_tag="SPC23A_0017" /note="HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.9e-25" gene 16529..17398 /gene="rmlA" /locus_tag="SPC23A_0018" CDS 16529..17398 /gene="rmlA" /locus_tag="SPC23A_0018" /EC_number="2.7.7.24" /note="member of homology group 10" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase RmlA" /protein_id="CAI33825.1" /db_xref="GOA:Q4K0F1" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="UniProtKB/TrEMBL:Q4K0F1" /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLAG IRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSVAL ILGDNIYHGPGLSTMLQKAAKKEKGATVFGYHVKDPERFGVVEFDENMNAISIEEKPEY PRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRGFAWL DTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRRGYISREDVLALAQSLKKNEYGQY LLRLIGEA" misc_feature 16532..17248 /gene="rmlA" /locus_tag="SPC23A_0018" /note="HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.7e-121" gene 17399..17992 /gene="rmlC" /locus_tag="SPC23A_0019" CDS 17399..17992 /gene="rmlC" /locus_tag="SPC23A_0019" /EC_number="5.1.3.13" /note="member of homology group 11" /codon_start=1 /transl_table=11 /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase RmlC" /protein_id="CAI33826.1" /db_xref="GOA:Q9AHA9" /db_xref="HSSP:1NXM" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="UniProtKB/TrEMBL:Q9AHA9" /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEKM LPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREGET FGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYADPS LGIEWENIAEAEVSEADKNHPLLKDVKPLKKEDL" misc_feature 17435..17965 /gene="rmlC" /locus_tag="SPC23A_0019" /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase, score 4.5e-16" gene 18005..19054 /gene="rmlB" /locus_tag="SPC23A_0020" CDS 18005..19054 /gene="rmlB" /locus_tag="SPC23A_0020" /EC_number="4.2.1.46" /note="member of homology group 8" /codon_start=1 /transl_table=11 /product="dTDP-D-glucose 4,6-dehydratase RmlB" /protein_id="CAI33827.1" /db_xref="GOA:Q9AHA8" /db_xref="HSSP:1KEP" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="UniProtKB/TrEMBL:Q9AHA8" /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNR ANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFI GTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSS TKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGK NVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAVDAYDHV TDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKEAVEANY AKTQEIITV" misc_feature 18020..18976 /gene="rmlB" /locus_tag="SPC23A_0020" /note="HMMPfam hit to PF04321, RmlD substrate binding domain, score 9.7e-05" misc_feature 18023..18763 /gene="rmlB" /locus_tag="SPC23A_0020" /note="HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 5.4e-77" misc_feature 18026..18838 /gene="rmlB" /locus_tag="SPC23A_0020" /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 1.6e-05" gene 19120..19971 /gene="rmlD" /locus_tag="SPC23A_0021" CDS 19120..19971 /gene="rmlD" /locus_tag="SPC23A_0021" /EC_number="1.1.1.133" /note="member of homology group 9" /codon_start=1 /transl_table=11 /product="dTDP-4-keto-L-rhamnose reductase RmlD" /protein_id="CAI33828.1" /db_xref="GOA:Q4K0E8" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR016040" /db_xref="UniProtKB/TrEMBL:Q4K0E8" /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEKV FEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTDYV FDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVF TMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYD FAVEILKGTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQE VR" misc_feature 19120..19968 /gene="rmlD" /locus_tag="SPC23A_0021" /note="HMMPfam hit to PF04321, RmlD substrate binding domain, score 1.6e-147" misc_feature 19123..19764 /gene="rmlD" /locus_tag="SPC23A_0021" /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 9.3e-05" misc_feature 19123..19752 /gene="rmlD" /locus_tag="SPC23A_0021" /note="HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 1.4e-19" misc_feature 19126..19854 /gene="rmlD" /locus_tag="SPC23A_0021" /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 1.4e-08" misc_feature 20053..20496 /gene="tnp" /locus_tag="SPC23A_0022" /note="HMMPfam hit to PF03050, Transposase IS66 family, score 7.1e-05" /pseudo="" ORIGIN 1 tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa 61 acactgcggc taaagaagta cttgaaaaac aggtcttggc tccatgggat gctttctgtg 121 tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcgta taaaaacaag 181 ggaagactgt ataaaaggca gaaatccttt gttttttata accaaggttt ataaaccttc 241 attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaata agacgaacat 301 aaagaagcgt atccttagtg caggcctgac ttttacatct gatttgcttt tagctgcttg 361 cggccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac 421 atttaactat ctattagact attacgctga taatatagtc aattgaaaca agaacaggac 481 aaaagagcct cataaaaggt attgcaactt ggtaatacct ttttgaggtg ctttttgata 541 tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt 601 ttatgcccaa actcttcaca caagagttct aacttaccca ttctatggaa tcttgcatta 661 tccataataa taaccgatgg tgtggttaat gttggtaaga aaaacttctg aaaccatact 721 tcaaaaaagt cgctcgtcat cgtctcttcg taagtcattg gagcgattaa ttcaccattt 781 gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt 841 aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttca 901 tcaatctaaa caggtgctag gtgctttaaa ctattaaaat tcttaagaaa taaggctact 961 ttttctgggt cttgttcata attagattga aactagaata gtacacatct gcttctaaaa 1021 cattgttaga aaacgatttg actgtcctga acaatttgtc atgttcttgt ttcattttac 1081 tatatttttg gttcgcggga agtctactaa gatacttaaa gatgcagata gtgaaaaaaa 1141 ggtgtagaca ttaccgtaaa aaagtgatat aatcgtatga tgttcaatgt ataggtgtta 1201 atcatgagta gacgttttaa aaaatcaggt tcacagaaag tgaagcgaag tgttaatata 1261 gttttgttga ctatttattt attgttagtt tgttttttat tgttcttaat ctttaagtac 1321 aatatccttg cttttagata tcttaatcta gtggtaactg cgttagtcct actagttgcc 1381 ttggtagggc tacttctgat tatctataaa aaagctgaaa aatttactat ttttctgttg 1441 gtgttctcta tccttgtcag ctctgtgtcg ctctttgcag tacagcagtt tgttggactg 1501 accaatcgtt taaatgcgac ttctaattac tcagaatatt caatcagtgt cgctgtttta 1561 gcagatagtg atatcgaaaa tgttacgcaa ctgacgagtg tgacagcacc gactgggact 1621 gataatgaaa atattcaaaa actactagct gatatcaagt caagtcagaa taccgatttg 1681 acggtcaacc agagttcgtc ttacttggca gcttacaaga gtttgattgc aggggagact 1741 aaggccattg tcctaaatag tgtctttgaa aatatcatcg agtcagagta tccagactat 1801 gcatcgaaga taaaaaagat ttataccaag ggattcacta aaaaagtaga agctcctaag 1861 acgtctaaga atcagtcttt caatatctat gttagtggaa ttgacaccta tggccctatt 1921 agttcggtgt cgcgatcaga tgtcaatatc ctgatgactg tcaatcgaga taccaagaaa 1981 atcctcttga ccacaacgcc acgtgatgcc tatgtaccaa tcgcagatgg tggaaataat 2041 caaaaagata aattaaccca tgcgggcatt tatggagttg attcgtccat tcacacctta 2101 gaaaatctct atggagtgga tatcaattac tatgtgcgat tgaacttcac ttcgtttttg 2161 aaattgattg atttgttggg tggaattgat gtttataatg atcaagaatt tactgcccat 2221 acgaatggaa agtattaccc tgcaggcaat gttcatcttg attcagaaca ggctctcggt 2281 tttgttcgtg agcgctactc actagcagat ggcgatcgtg accgcgggcg caatcaacaa 2341 aaggtgattg tggctatcct tcaaaaatta acgtcaaccg aagcactgaa aaattatagc 2401 acgatcatta atagcttgca agattctatc caaacaaata tgccacttga gactatgata 2461 aatttggtca atgctcagtt agaaagtgga gggaattata aagtaaattc tcaagattta 2521 aaaggtacag gtcggacgga tcttccttct tatgcaatgc cagacagtaa cctctatgtg 2581 atggaaatag atgatagtag tttagctgta gttaaagcag ctatacagga tgtgatggag 2641 ggtagataaa atgatagaca tccattcgca tatcgttttt gatgtagatg acggtcccaa 2701 gtcaagagag gaaagcaagg ctctcttgac agaatcctac aggcaggggg tgcgaaccat 2761 tgtctctacc tctcaccgtc gcaagggcat gtttgaaact ccggaagaga agatagcaga 2821 aaactttctt caggttcggg aaattgcaaa agaagtagca gatgatttag tcattgctta 2881 tggcgcagag atatactata ctctggatgc tctagaaaag ctagaaaaaa aagaaattcc 2941 taccctcaat gatagtcgtt atgccttgat agagtttagt atgaacactc cttatcgcga 3001 tatccatagc gccttgagca agatcttgat gttgggaatt actccagtca ttgcccacat 3061 tgagcgctat gatgctcttg aaaataacgg aaaacgtgtt cgtgaactga ttgatatggg 3121 gtgctatact cagataaata gttatcatgt ttcaaaacct aagttctttg gtgaaaaata 3181 taaattcatg aaaaagagag ctcggtattt tttggaacgt gatttagttc atgtagttgc 3241 aagtgatatg cacaatttag acagtagacc tccatatatg caacaggcat atgatatcat 3301 tgctaagaaa tatggagcga aaaaagcgaa agaacttttt gtagataatc ccagaaaaat 3361 tataatggat caattaattt aggagaaaat atgaaggaac aaaacacttt ggaaatcgat 3421 gtattgcaac tattcagagc tttatggaaa agaaagttgg tcattttatt agtggcaatt 3481 ataacttctt cggttgcttt tacctacagt acttttgtta tcaaacctga gtttactagt 3541 acgactcgga tttatgtagt taaccgtaat cagggagaga agtctggttt aaccaatcaa 3601 gacttgcagg caggaacata cttggttaaa gactatcgtg aaattatcct atcgcaggat 3661 gttttggagg aagttgtttc tgatttgaaa ctagatttga cgccaaaagg tttggctaat 3721 aaaattaaag taacagtacc agttgatacc cgtattgtct ctgtttcagt taatgatcga 3781 gttcctgaag aggcaagccg tatcgctaac tctttgagag aagtagctgc tcaaaaaatt 3841 atcagtatta ctcgtgtttc tgatgtgaca acactggagg aggcaagacc ggcgatatcc 3901 ccgtcttcgc caaatattaa acgcaatata ctaattggtt ttttggcagg ggtgattgga 3961 actagtgtta tagttcttct tcttgaactt ttagacactc gtgtgaaacg tccggaagat 4021 atcgaagata cactgcagat gacacttttg ggagttgtac caaacttgaa taagttgaaa 4081 taggagagag agatgccgac attagaaata gcacaaaaaa aactggagtt cattaagaag 4141 gcagaagaat attacaatgc cttgtgtaca aatatacagt tgagcggaga taaactaaaa 4201 gtaatttccg ttacttctgt tagccctggg gaaggaaaaa caactacttc cgtaaatata 4261 gcatggtcgt ttgcgcgtgc aggctataaa actcttttga tcgatggcga tactcgaaat 4321 tcagttatat caggattttt taaatctcgt gaaaaaatta cagggctaac agaattttta 4381 tctgggacag ctgatttatc tcacggttta tgtgatacaa atattgaaaa tttatttgta 4441 gttcaatcgg gatctgtatc accaaaccct acagccttgt tacaaagtaa aaattttaat 4501 gatatgattg aaacattgcg taaatatttt gattatatca ttgttgatac agcacctatt 4561 ggaattgtta ttgatgcggc aattatcact caaaagtgtg atgcgtccat cttggtaaca 4621 gcaacaggtg aggcgaataa acgtgatgtc caaaaagcga aacaacaatt aaaacaaaca 4681 ggaaaactgt tcctaggggt tgttttaaat aaattagata tctcggttga taagtatgga 4741 gtttacggtt tctatggaaa ttatggtaaa aaataattta ggaaagattc tatggatgaa 4801 aaaggattga aaatttttat ggcagtatta cagagtatta ttgtcatttt attggtttat 4861 tttcttagct ttgttagaga gacagaactt gaacgttctt cgatggttat actatacctt 4921 ctccactttt ttgtattcta tgttagttcc tatggtaaca atttttttaa aagagggtac 4981 ctagttgagt ttaatagtac tataagatat atttttttct ttgcaatagc tataagtgta 5041 ttaaactttt ttatagcgga acggtttagt atctctagaa gaggaatggt atacttctta 5101 actttagaag gaatatcctt atacttgtta aatttcttag taaagaaata ttggaaacat 5161 gtgtttttta atctaaaaaa tagcaagaaa attttactgt taacagtaac gaaaaatatg 5221 gaaaaagttc ttgataaatt gctagaatct gatgaacttt catggaagtt ggtagcagta 5281 agtgttttga ataaatctga ttttcaacat gataaaatac ctgtaattga aaaggaaaaa 5341 attattgaat ttgcaacgca tgaagttgtg gatgaggtgt ttgtcaatct tccaggagag 5401 agctacgata ttggagaaat tatctctagg tttgagacaa tggggataga tgtaactgta 5461 aatcttaaag catttgataa gaatttgggt cgcaataaac aaattcatga gatggtagga 5521 ttgaatgtag tcactttctc tacaaatttt tataaaacta gtcatgtgat ttcaaagaga 5581 attctcgata tttgtggtgc cactattggc cttattcttt ttgctatagc tagtctagtt 5641 ttagttccat tgattcgtaa agatggcgga ccagctattt ttgctcaaac tcgtataggg 5701 aaaaatggtc gacattttac cttttataaa ttccgttcga tgaggatcga tgctgaagct 5761 atcaaagaac agttgatgga tcaaaatacg atgcaaggtg gtatgtttaa gatagacaat 5821 gatcctcgtg ttacaaaaat tggtcgcttt attcgtaaaa ccagtttaga tgaattgccg 5881 cagttttgga atgtctttat aggagatatg agtttggtgg gaacacgtcc acctacagta 5941 gacgagtatg atcagtatac tccagaacaa aaacgtcgac tcagctttaa acctggtatt 6001 acaggtttat ggcaggttag cggccgtagt aaaataaccg attttgacga tgttgtaaaa 6061 ttagatgtgt cttatattga taattggaca atctggaaag atattgaaat tttgcttaaa 6121 actgttaaag ttgtatttat gagagatgga gcgaagtaat ttctgtatat ccatcatatt 6181 aggagagaaa tgaaaaagtc agtttatatc attggttcaa aaggaattcc tgctaagtat 6241 ggaggatttg aaacttttgt tgaaaaatta acagccttcc aacaagataa ggctatccaa 6301 tattatgtgg cttgtatgcg tgaaaactct gcaaaatcag ggactactga ggatgttttt 6361 gaacataatg gtgctatctg ttataacgtc gatgttccta atattggtcc agcgcgagcc 6421 atagtatatg atatcgcggc aattaacaga gctattgaaa ttgccaaaga aaataaggat 6481 gaagatccaa tcttctatat tttagcttgt cgaatcggtc cgttcatcca tggaattaag 6541 aaaaaaatcc aggcgatagg tgggactctt ctagttaatc cagatggtca cgagtggtta 6601 cgagctaagt ggagcactcc agttcgtcgt tattggaaaa tttccgaagg tcttatggtc 6661 aaacatgcag atttattggt ttgtgacagt aaaaatatcg aacagtatat ccaagaagat 6721 tataaacagt tccaacctaa gaccacctat atcgcttatg ggaccgatac aacacgctcc 6781 atattaaaga gtagtgatga aaaagtacgt tcttggttca aagagaagaa tgtttctgag 6841 aacgagtatt atctagttgt aggacgattt gttccagaga ataactatga atctatgatt 6901 cttggcttct tggcttctaa ctctaagaag gactttgttt taattacaaa tgtagaacag 6961 aataaatttt ataatcagtt gttggcaaaa actggttttg ataaagatcc acgagtaaaa 7021 tttgtaggga cagtctacaa ccaagagctt ctaaagtata ttcgagaaaa tgcttttgct 7081 tacttccacg ggcatgaagt tggtggaaca aatccttcgt tacttgaagc attagcatcc 7141 acaaagttaa acttactact cgatgttggc tttaaccgag aagtagctga ggatggtgct 7201 gattactggg aaaaagataa tcttcataag gttattgaag cgagtgaaca aaaaacacaa 7261 gaagagataa atgaaaaaaa tatactgtca acaaagcaag tgacggagcg cttctcttgg 7321 gatttgatag ttaatgagta tgagaaactt tttacgagaa aaaactagaa actcataagg 7381 gattatttga ataaataagt ttttgctttt tctcattgat agaacaataa gattgcttta 7441 gtaaataata attagaaaac tgtatataaa atttcataat atggaaaatg agtttcgaag 7501 agaagagtac atatgtcatg aatgtagtaa ttgataacag aaaattaggg gggataagtt 7561 gaaagtagat atgatttttg aggtacggaa taatgagaat tagttttagt aaaaaaacta 7621 tgctgtgtgg tttattgtat attggtttaa ttttatccgt agtaacaata cctacaattg 7681 taacattttt atattctttg ctattcatcg ggattgtaac agtcttaaat tataattcta 7741 ttctagcaag tgacgaagat gcgaactctt tttttgttgc attacctatt attttatctt 7801 cttttcaaaa tgtatatttg ggatttggag cggatcgatt aaattctgtc acactacaag 7861 ttctgctatc tattagcatt gctattatta caattacagt ttttctaggt attatcttaa 7921 atagattcaa atcaaaagaa tttagttggt tagttttaag tattcttgta attataattc 7981 aatcagtaat tcttttaata ttctttccca ctaccttgcc agcatattta tcatctatga 8041 gaaatatact agccccacta ctgatttttt atttttctat ctatgggttt aaaaatatta 8101 atttacaaaa attttataaa tatatgttca taattatatt agttgttcta atttttggat 8161 ttattgagta tatatacgga aatagtttat ggacaagatt gaatattaaa aagctttggg 8221 ctttgaaggg gctggcgatt gagaataggg ttgttcctgg gaattggcac tcttctgaat 8281 taattggcgg taaacaatta aggcgtatgg tttcaacatt tgccgatccc gtaaatctag 8341 gttcgtatct ctttgcggca tttatgttag cttggtacaa aaataagaaa ctacttcaag 8401 ttttattgct cgcttctttt gtactcagtg taagtaaagc agcgttttta agcatgttgg 8461 tatatataat aatttatacc tgggttgtgg ataaaaataa aattttatcg atttttggaa 8521 taataatttc aactgtattg gggttgtatt tttataattt tagtcaagtt agcagttatg 8581 gtagtataaa tgcacatatc gatggttttt ttagtgcgtt aagtactccc ctccattacc 8641 catttggtat gggagtaggg agtgtgggag ttctagcttc aaaattaggt tcacaaacag 8701 cactttcttc agaggtttta gaaacaggaa ttggaatgat aattgctcaa ttaggattcg 8761 tgggtgtgat aatatatttg attttctttg taaaactctc cgtaatagga aagaatatta 8821 ataataaaag agataaaatt ttatggttta ctttaattta tagctttttg gctaatgcct 8881 tttttaacga ggttgcactt tctcctaact catgcacctt atatttttta attttaggac 8941 tgctttataa taaaaataaa attagaagca cagagtttag ttaatggaaa aattagttag 9001 tattattctg cccgtctaca atgtcgaaca gtatataaaa aattgtttag aatcaattca 9061 acaacaaact tatccaaatt tggaagtaat cattgttaat gacggttcaa ccgataaaag 9121 cgttgaatat tgtgagcaaa tttgtaagat agattctagg ttttctatca ctcacaaaga 9181 aaatggtgga ctttccgatg caagaaatgt cggtatagat aaagccaagg gagattacct 9241 catttttgtt gacagtgatg attttgtttc tcaagatatg gtatcttatt tagtatcttg 9301 tatggagaac aatgaggcag acattgctat ttgcgatcct gttcattatt atagtgatcg 9361 tcaaaacaat gatcttaata ttttttctcc agcatcaagc gttaaggttt acgaaacaac 9421 ggaggctcta tgtgagatgt tttatcaaaa atcttttttg gtgtctgcct gggccaagat 9481 atttaaaaga gagttgtttg atgatataag atttcctgta ggtaagctat ttgaagatag 9541 tgcgattatg tatttgctcc tcgaaaagtg tgaaacaatt gcatactctg atgcgaaatt 9601 atatgcttat gtacacaggg ataatagtat cacaacaaag aaattttcgg atagagactt 9661 agatattttg gagattacga acacaattat taatcactat ggtgataatt tacgcgtgta 9721 tactgcagcg gtgtcttata aggtatctgc atgtttcaga attctattaa actcaccttc 9781 tgaagaaaag tataaaaaag tacaaaaaga atgtttgagt tatattttac aaaattggag 9841 aaacatatta tttaataata atgttcgatt gaagaacaag cttgccttaa tttctataac 9901 tattttcaat ccttttgtta aattgatcta tagtaaagta aacagatggg aatgatagca 9961 aatgaacaaa tatgaagaaa gatatcaaga aaatttatct aagaatgatt tttataaatt 10021 aattaataag agttacttat cagataaaga acttcaagta caacaagtaa aagctgggat 10081 agtcttacca ccaaaggcat ttgaaacaaa attatcaaat aaacttggcc tacaaaaatc 10141 tttgcatgga aagggtggag ttgtagactc aaatggaaat tacattgaac tatctgcaca 10201 aaaagcagtc gggatgagaa atagagtcta tggtccgtat aaaattaatt acgataatct 10261 gccaattaga aatgaaaaag taatctattt gaactatttc atcaaacaat ggggacattt 10321 tttactggat gttgttggaa ggttatggta tccattgctg caggataatg atactaagtt 10381 agtctatacc tgctatgctg gaacagaaac aaagattgag ggaaactatt tagagttttt 10441 gaagcttctc ggcatagatc aatcacgttt aatcatgata aactgtccca ctcagttctc 10501 agaagtcatt attcctgaaa gctccatttt accgggggga tattatacaa aagagtataa 10561 acaactattc agttcggtag tagaaaatat taaattggac aagtatgatg tgaatgctaa 10621 aatgatttat tgttcgaggt ctaaattagg gattgctaaa agtaaagaat ttggcgaaga 10681 cggtattgag gggattttta aacaaaatgg ctatacatct gtttacatgg aaacaatgtc 10741 tttggaagag caaataaaaa ccttattatc ggctaagaca atagtattaa cgagtggttc 10801 gttagcacat aatcttttat ttgtaaataa agatattgat gtttttattt tgaataaaac 10861 ctatagagta aatctccatc aatttttaat aaacgagatc tcagatgcta cagtaagatt 10921 tgtagatatc tatcgatcac ctttaccgat tttatacgga tatggaccat ttttaatgga 10981 tcttacaaaa cctttggcta atttcttgga cgataatgaa tttgtatatg aaaaaggtac 11041 tgttttaagt aaaaaagatt attttaaata ctatttgaaa tggttgtgga gttatagatt 11101 ctttttattt aggttaaatg gtattaaaga aggaaatagt gaattcgaga agagttttaa 11161 gataattagg agatactata aaacaggacg atagaatgag taaatataag gaattagcaa 11221 aaaatacagg tatttttgct ttggctaact tttcatcaaa gattttaatt tttttgttag 11281 tacctatata tacacgggta cttaccacta cggaatatgg tttttatgac ttagtctata 11341 caactattca gctttttgta ccaatcttga cattaaatat atctgaagcc gttatgaggt 11401 tcctaatgaa agatggtgtt tctaaaaaat cagtcttttc aattgctgtt ttagatatat 11461 ttattggatc aattgctttt gctttattgt tgttagtaaa taacctgttt tctttatcag 11521 atttaatttc tcaatacagt atttacatat ttgtaatctt tgttttctat accctaaata 11581 attttttgat acaattttct aagggaattg ataaaattgg tgttacagct atctctgggg 11641 tcataagtac agcagttatg cttgccatga atgtcattct tctagtagta tttgattggg 11701 gattgttagg tttctttatt gctaatgttt gtggatatgt tataccttgt atttatatag 11761 tttctagatt aagattgtgg gaattatttg aaattaagat tgataaaaaa ttacaatggg 11821 aaatggttta ctatgctttg ccattagttt taaatatatt aagctggtgg gtaaataata 11881 cttcagatag atatattgtg actgcaatag taggtataca agctagtgca attatttcag 11941 tcgcttataa aattccacag attttgtcta cgattagtgc aatttttatt caatcatggc 12001 aaatctctgc aattaaaata caagaagata agagcggtac tacatttgta tcaaacatgc 12061 tcctatacta taatgcactt ctattgatta tagcgagtgg tatcatatta tttgtcaaac 12121 ctatttctaa tatattgttt ggtatttcct tctattctgc gtgggagctg gtaccatttt 12181 taataattag cagtctattc aatgcaattt caggttgtat aggagcaatt atgggagcta 12241 aaatggatac tcataacatt gcaaagtcgg ctttagttgg gatgattgca aatattattt 12301 taaatatagt gttaacattc ttaatgggtc cacagggaat tacaatttct accctgatag 12361 ctagttttct tattttttat atgcgaaaag atagtgtaaa agaaattaat tcagaaacat 12421 atagagcaat ttatttatcg tggatactat tagttgtaga ggcctgtctg ctaatttata 12481 tggattttat tattggtgct ttaatagcaa tggtaataaa cttattttta ctaaaagatg 12541 ttatcaaacc tttatattta aaaattttca aaagaaatta ggtacaaaat gattgtttta 12601 caatacttta agattttagc tagattcgtt tttatgtttt tgataagtgc ggtgttactg 12661 cctttcaaaa taaaacctaa taagattgtt tttattaatt tcaatgggaa aggatatggt 12721 gataatccga aaagtatttg tgagtatctt agaactactt acccagattt agatttggtt 12781 tggcttgcaa gagataacga aggttttcca gatggggtta gggttgttaa atatgggact 12841 ttccaagctt tttatgagca agcgagttcg aaggtttggg tatataatgt aagagctttt 12901 gcaagaatac taaaaaaacg aggacagatt tatattcaaa cttggcatgg tgcttctagt 12961 tttaagttga tagaaaaaca agctgattta ccaataaatt atgttttaga agctaagtat 13021 gatgcaagag tcacagatat aatgatttca gatagcagaa aacaaactga agaatttcaa 13081 aagtattttt ggtattcagg agaaattttt gaggtgggga tgccgagaaa tgatgccttg 13141 tttcactata aggaagacta cgacaagtta aataatatca gaaaagaact aagcattcat 13201 tcagatgatt atgttatttt atatgcccct actttcagag atgatgggga tgcatcttat 13261 ttagatataa attttgaacg gcttttgcaa tgtgttgaac acggaattaa aaagaaatgt 13321 aaattcttaa ttaggttaca ccctaatcac tcccatttgt gtaataatat ttcatttaat 13381 aagaatataa tcaatgctac gttttattca gatatgcaag agcttacttt gttggcagat 13441 gttttagtca cagattattc ttcctcgata tttgatttta tgcttttaaa caagccttat 13501 gtcagatatg tgaatgattt agaaaaatat gctgagctta ggggggtatc agatacatat 13561 tacgaattgc cggattcgat tattaaaact gctgaagaat tgtatgactt actgcctaaa 13621 aaaatagaaa attttgatta tgattctata aaaaaatata gaaatgaaat actgtgtcca 13681 atctttaatg gaaccgctag tgaaaatgta ggaaggagaa taattcaaga gttgtgaagt 13741 aaaacattgg gttattttta aggtaacgag atttgaaaaa taatgattta aagataggaa 13801 gtggagctat tcatcaaatt tccgctacac tttctcaaaa tagtatttcg ggaaagattt 13861 tatattgtgc tgatccagtt gtcgatgact tgtacggttc gatagtacgt tcacaaatag 13921 aggaaattgg tcgggtaaag gaagaaagtt gcaattataa tactattgct tatgcgatga 13981 atatagcaga acgggctatt gccacagata ttgactgtat tgtgggaatg ggaggaggtc 14041 gtgttttaga tgtctgcaag tatgcatctt ttatttcgaa acgtccttac ctatcgattc 14101 cgacaacagc agcaaatgat ggcattgctt ccccagttgc tgttttgaaa aggcaggatg 14161 atagaccaaa aagcttaggg gcggctatcc cctcaatgac actaattgat attgatgtta 14221 ttgcatcagg acctatacaa aatataaaag ctggtatcgg tgatacaata tccaattaca 14281 ctgcattgaa agattgggag ttggcagttg agcgagggaa agatgagatg catggttttg 14341 catatctaat gtcgcaaaat tctttagatg ctttaatgaa aacgaagtat aattctatta 14401 cccctgattt tattgaagtt ttggtaaact ctttagtttt atcaggcatt gcaatggatt 14461 ttgcgggaag tagtagacct gtcagtgggt cagagcactt atttagtcat gcattagatt 14521 actatggttc tacaaggaat cttcatggaa ttcaggttgc attaggtaca gtcgcagttt 14581 tgaaattaat tgaaaattct gttgatactg tagtggatta cttgcaaaga tttgaggttc 14641 atattaaccc gaaacttttg gggatagatg aagagttgtt tatttattgt atgcaacatg 14701 ctacaaaaat gagaagtaat cgctatacct atctgcatga agttgatctt agcacagata 14761 gattgaaaca aatatataag gaactcataa gcgagttgta gagaagagag gaaaaaatga 14821 aagcacttat tttagcagca gggttaggaa cacgtctagc tccaattacc aatgaggtac 14881 caaaatcttt ggtaccagtc aatggtaagc caattttgat gaaacaaatt gaaaatttat 14941 atcaaaataa tattacagat attacgatta ttgctggata taagtcatct gtattaacag 15001 atgcagttac tgaaaagtat ccagaaatta atattattga taatgttgat tttaaaacga 15061 ctaataatat gtattcagcc tatctaggaa aagctgcaat gggtgatagt gacttcttaa 15121 tgatgaatgc agatgtattt tatgatgctt ctgttattaa aagtctgttg cttcataaag 15181 ctccaaatgc aattgtaact gatttaggta tttatattga agagtctatg aaagtcgtag 15241 aaaaaaatgg tcgtttagta gaaatttcta aacagatttc acctgaggaa actttaggag 15301 cttctattga tgtttataaa ttctcttatg aagcaggtgc tcgattcttt gaaaagtgta 15361 aggaatttat tgaagataaa cgagaacttc aaatgtggag tgaggttgct cttaatgcaa 15421 ttctttctga agttgaattt gtagcatgtc cattagaggg tcgttggtta gaaattgata 15481 atcatgaaga cttagttgct gcagaaaaac tatttgcttg aaccgaatac ggagaatgaa 15541 attgacaaat agagttgatt attttggtgc tgatattagt gaacttcaga ataaaaaatt 15601 attcttattt gatatggatg gtaccattta tgaagaagat aggttgtttg agggtactct 15661 cgaattatta gactatattc ataatattgg cggtgagtat atttttatta caaacaattc 15721 atctaagtct gttgttgact atgttgaaaa agttaacaga ttaggtatta aagctgaacg 15781 agataatttt tttacctctg ctcaagccac aattgtttat attaaagaaa attatcctaa 15841 atctaaagtt tattgccaag gaacaaaatc tttgataaaa gaactatctg acgcaggaat 15901 tgatgtaact gagcaagtta gtgctgatat agatgttgtt cttgttggtt ttgatacaga 15961 attaaccagt gataaaattc gcaatacctg cgagattcta tcaacaaagg acgtaccttt 16021 catagctact aaccctgata ttcgctgccc agtatcgttt ggattcatcc cggattgtgg 16081 ttctatttgt gatatgatta gtaaatcagt cgataggaaa cctgtttaca taggtaaacc 16141 tgaacctacg atggttgata ttgttcgaaa aaaattaaat tattctctat ttgaaacagt 16201 tgtgattgga gatcgcttgt atacggatat catgactggt ataaatgcag gagtaacttc 16261 agtttgtgtg ctgacaggag aagcaacggt gaatgatatt caacaagata gtataaaacc 16321 gacttataca tttaaaaacg tgaaagaaat gtggaaagga attgtctgat tttttcattc 16381 tgaatagtga attcatgaat actgtcaaaa tactcgtatg tatttaaatt gattttatta 16441 ttttaataat ggacaaatta aaattatttt tctccccaaa tcgttcgtga acgtaaagta 16501 ctcatcaaca aagaaaggta ccccttttat gaaaggtatt attctagcag gtggttcggg 16561 aactcgcttg tatcctttga ctcgcgctgc atcaaaacaa cttatgccgg tttatgataa 16621 accgatgatt tactacccac tttcaacatt aatgttggct gggattaggg atattttgat 16681 tatctcaact cctcaagatt tgcctcgttt taaagagctt cttcaagatg gttctgagtt 16741 tggtattaaa ctttcttatg ctgagcaacc aagtccagat ggtttggcac aagcctttat 16801 cattggggaa gagtttatcg gtgacgatag cgttgccttg attttaggtg acaatatcta 16861 ccatggtcct ggtctgagca caatgcttca aaaagcagcc aagaaagaga aaggtgcgac 16921 tgtttttggc taccatgtca aggatccaga acgctttggt gttgtagaat ttgatgaaaa 16981 tatgaatgct atctccatcg aagaaaagcc agaataccct cgttcaaact atgcagtgac 17041 aggactctat ttctatgata atgatgtagt agagattgcc aaaagtatta aaccaagtcc 17101 tcgtggtgaa ttggaaatta cagatgtcaa caaggcttac ttggatcgtg gtgatttgtc 17161 tgttgagctc atgggacgtg gttttgcttg gttggatact ggcactcatg aaagtttact 17221 agaggcttcg cagtacatcg aaacagtcca acggatgcaa aatgttcagg tagcaaactt 17281 agaagaaatt gcttaccgta ggggctatat cagtcgagaa gatgtattgg ccttagccca 17341 atcacttaag aaaaatgaat acggacagta tctgctccgt ttgattggag aagcatagat 17401 gacagataat tttttcggta agacgcttgc ggcacgcaag gttgaagcta ttccaggcat 17461 gttggagttt gatatccccg ttcatggaga taatcgtggc tggtttaaag aaaatttcca 17521 aaaggaaaaa atgcttccac ttggatttcc agagtctttc tttgcagaag gaaaattgca 17581 aaacaatgta tccttctcac gtaaaaatgt ccttcgaggc ctccacgcag agccttggga 17641 taagtacatc tctgtagcag atggagggaa agttctgggt tcttgggttg atctacgcga 17701 gggtgaaacc tttgggaata cctatcagac agtgattgat gcgagtaagg gaatctttgt 17761 tcctcgaggc gtagctaatg gcttccaagt tttatcagat acagtgtcat atagctatct 17821 ggtcaatgat tactgggctc ttgaactcaa acccaagtat gcctttgtga actacgctga 17881 tccaagcctt ggtattgaat gggaaaatat tgcagaagca gaggtttcag aagcagataa 17941 aaatcatcca ctacttaagg atgtaaaacc tttgaaaaaa gaagatttgt aaaaaggaaa 18001 gaatatgact gaatacaaaa atattatcgt gacaggtgga gctggcttta tcggttctaa 18061 ctttgtccat tatgtttacg agaactttcc agatgttcat gtgacagtcc tagataagtt 18121 gacttatgct ggaaaccgcg cgaatattga ggaaatttta ggtaatcgtg ttgagttagt 18181 tgttggtgac attgctgatg cggagttggt agacaagttg gctgctcaag cagatgctat 18241 cgttcattat gcagcggaaa gccacaatga taattcgctc aatgatccat cgccatttat 18301 tcatactaac ttcatcggaa cctatactct tttagaagct gctcgtaagt atgatattcg 18361 cttccaccat gtatcgacag atgaagttta tggggatctc cctttacgcg aagatttgcc 18421 aggtcatggt gaaggaccag gtgagaaatt tactgctgaa acaaaataca acccaagctc 18481 tccgtactca tcaaccaagg cagcctcaga tttgattgtc aaagcctggg tgcgttcttt 18541 tggagtcaag gcaacgattt ccaactgttc aaataactac ggtccttatc aacatatcga 18601 aaaattcatc ccacgtcaga ttactaacat cctaagtgga attaagccaa aactttacgg 18661 tgaaggtaag aatgttcgtg actggattca taccaatgac cattcttcag gagtttggac 18721 aatcttgaca aaagggcaaa tcggtgaaac ctacttgatt ggggctgatg gtgagaagaa 18781 caataaggaa gttttggaac ttatccttaa ggaaatggga caagctgtgg atgcctatga 18841 tcatgtgact gaccgtgcag gacatgacct tcgctatgcg attgatgcta gcaagctccg 18901 tgatgagttg gggtggaaac ctgaatttac caactttgaa gctgggctca aggcaacaat 18961 caagtggtat acagataacc aagaatggtg gaaagcagaa aaagaagctg ttgaagccaa 19021 ttatgctaag actcaggaga ttattacagt ataaaaagca ggaaatagct gctttttatt 19081 gctatattgg gaagagttac atattagaaa ggtctagaga tgattttaat tacaggggca 19141 aatggccaat taggaacgga acttcgctat ttattggatg aacgtaatga agaatacgtg 19201 gcagtagatg tggctgagat ggacattacc gatgcagaaa tggttgagaa agtttttgaa 19261 gaggtgaaac cgactttagt ctaccactgt gcagcctaca ccgctgttga tgcagcagag 19321 gatgaaggaa gagagttgga cttcgccatc aatgtgacgg ggacaaaaaa tgtcgcaaaa 19381 gcatctgaaa agcatggtgc aactctagtt tatatttcta cggactatgt ctttgatggt 19441 aagaaaccag ttggacaaga gtgggaagtt gatgaccgac cagatccaca gacagaatat 19501 ggccgtacta agcgtatggg ggaagagtta gttgagaagc atgtgtctaa tttctatatt 19561 atccgtactg cctgggtatt tggaaattat ggcaaaaact tcgtttttac catgcaaaat 19621 cttgcgaaaa ctcataagac tttaacagtt gtaaatgacc agtacggtcg tccgacttgg 19681 actcgtacct tggctgagtt catgacctac ctagctgaaa atcgtaagga atttggttat 19741 tatcatttgt caaatgatgc gacagaagac acaacatggt atgattttgc agttgaaatt 19801 ttgaaaggta cagatgtcga agtcaagcca gtagattcca gtcaatttcc agccaaagct 19861 aaacgtccgc taaactcaac gatgagcctg gccaaagcca aagctactgg atttgttatt 19921 ccaacttggc aagatgcatt gcaagaattt tacaaacaag aagtgagata agtagtagaa 19981 tgattttcta gtctaataaa agaggcagat aatgaactcc aaaggagctt aagatgtacg 20041 attatcttgt tgttggtgct gatctctttg gcgcatagct ttggctcagt ttctattatc 20101 gctcacacca tccatcagaa gtttaatctg aaggtaccca attatcgcca agaagaagat 20161 tgggctagga tgggtttacc aatcacacgt aaggaaatct ctaattggca tatcaaggca 20221 agtcaatact atttagagtc cctttataac cttttacgag aaaagttgtt agaacaacct 20281 cttcttcatg cggatgaaac ttcttatagg gtgctagaga gtgatagtca gctgacttac 20341 tattggacct ttttgtctgg gaaagctgag aatcaagcaa tcacgctgta ccaccatgat 20401 cagcgtcgga gtggtttagt agtacaagaa ttcctaggag attattctgg ctatgttcat 20461 tgtgacatgt tgcggcagta acttaggact ttagtcctct agttctgcct atgcgatagc 20521 agtccaaggt ttaggagcaa ggcgacgcta agcttggtaa actgcgaacc gctagaagct 20581 tatcgtcaac tggaagaagc tgaacttgtt ggatgttggg cgcatgtgag aaggaagttt 20641 tttgaagcga cccccaagca agcggataaa tcatcgttag gagctaaagg tttagcttat 20701 tgtaatcagt tattttcctt ggaaagagac tgggaggctt tgccagctga tgaacgacta 20761 cagaaacgtc aagaagagct ccaaccccta atggaagact tctttgcttg atgccggcgt 20821 cagtcagttt tatcgggttc aaaactagga agggcaattg aatacagcct caagtataaa 20881 gaaaccttta agactatttt gaaagacgga catctggtcc tttccaataa tctagctgaa 20941 tgcgccatta aatcattggt tatgggacgg agtaaaagag tccagtggac tcttttagcc 21001 taagctcagt ttaaaaaagc gagggtggtt attttctcaa aattttgaag gagctaaagc 21061 aagagctatt attatgagtt tgttggaaac agctaaacgt catcaattaa atagcgagaa 21121 atatctatcc tatcttctag aatgtcttcc aaacgaggaa actctcgtaa acaaagaggt 21181 tttagaggcc tatttaccgt ggactaaagt tgtacaagaa aagtgtaaat aagaaatctc 21241 cagattagga actatccgtg agttctctag tctggagatt tttcaatata cttcgttatt 21301 ggacggttac gatattcata ttttttgcaa agatgttgtt tgaaaaataa ttttcaaaaa 21361 ttctgaaaat tctgttgaca actttctgaa aagagtctat aatggagaga aagttttaaa 21421 ggagaaaatg atgaaaagtt caaaactact tgcccttgcg ggcgtgacat tattg //