LOCUS AAXF02000054 10317 bp DNA linear BCT 04-AUG-2012 DEFINITION Bacteroides ovatus ATCC 8483 B_ovatus-MSIQ_Cont457, whole genome shotgun sequence. ACCESSION AAXF02000054 VERSION AAXF02000054.1 DBLINK BioProject: PRJNA18191 BioSample: SAMN00627058 KEYWORDS WGS. SOURCE Bacteroides ovatus ATCC 8483 ORGANISM Bacteroides ovatus ATCC 8483 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides. REFERENCE 1 (bases 1 to 10317) AUTHORS Sudarsanam,P., Ley,R., Guruge,J., Turnbaugh,P.J., Mahowald,M., Liep,D. and Gordon,J. TITLE Draft genome sequence of Bacteroides ovatus (ATCC 8483) JOURNAL Unpublished REFERENCE 2 (bases 1 to 10317) AUTHORS Fulton,L., Clifton,S., Fulton,B., Xu,J., Minx,P., Mardis,E.R. and Wilson,R.K. TITLE Direct Submission JOURNAL Submitted (15-FEB-2007) Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park, St. Louis, MO 63108, USA REFERENCE 3 (bases 1 to 10317) AUTHORS Fulton,L., Clifton,S., Fulton,B., Xu,J., Minx,P., Pepin,K.H., Johnson,M., Thiruvilangam,P., Bhonagiri,V., Nash,W.E., Mardis,E.R. and Wilson,R.K. TITLE Direct Submission JOURNAL Submitted (27-MAR-2007) Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park, St. Louis, MO 63108, USA COMMENT Bacteroides ovatus (GenBank Accession Number for 16S rDNA gene: X83952) is a member of the division Bacteroidetes. In one comprehensive 16S rDNA sequence-based enumeration of the colonic microbiota of three healthy adult humans, it represents, on average, 0.034% of all 16S rDNA sequences and 0.071% of the sequences in its division (Eckburg et. al. (2005)). The sequenced strain was obtained from ATCC (ATCC 8483T). We have collected 6.9X coverage in plasmid end reads and 454 reads. We will be performing one round of automated sequence improvement (pre-finishing). Sequencing/Assembly: The genomic DNA was purified from liquid culture derived from a single bacterial colony. A hybrid sequencing strategy that utilized reads from both 454 GS-20 and ABI 3730xl sequencers was devised and implemented to generate the draft genome sequences. 454 reads were assembled using Newbler (454 Life Sciences) into 454 de novo contigs. These de novo contigs were converted in silico to 800 base paired reads ('superreads') with 400 base overlaps with neighboring superreads. Finally, PCAP (Huang, et al, Genome Research, 13:2164, (2003)) was used to assemble the super-reads and the conventional 3730xl capillary reads. This sequenced strain is part of a comprehensive, sequence-based survey of members of the normal human gut microbiota. A joint effort of the WU-GSC and the Center for Genome Sciences at Washington University School of Medicine, the purpose of this survey is to provide the general scientific community with a broad view of the gene content of 100 representatives of the major divisions represented in the intestine's microbial community. This information should provide a frame of reference for analyzing metagenomic studies of the human gut microbiome. Further details of this effort are described in a white paper entitled 'Extending Our View of Self: the Human Gut Microbiome Initiative (HGMI)' (http://www.genome.gov/Pages/Research/Sequencing/SeqProposals/HGMIS eq.pdf). These studies are supported by National Human Genome Research Institute. Coding sequences were predicted using GeneMark v3.3 and Glimmer2 v2.13. Intergenic regions notspanned by GeneMark and Glimmer2 were blasted against NCBI'snon-redundant (NR) database and predictions generated based on proteinalignments. RNA genes were determined using tRNAscan-SE 1.23 or Rfamv8.0. Gene names are generated at the contig level and may notnecessarily reflect any known order or orientation betweencontigs. For answers to your questions regarding this assembly or project, or any other GSC genome project, please visit our Genome Groups web page (http://genome.wustl.edu/genome_group_index.cgi) and email the designated contact person. Annotation was added to the contigs in August 2007, and the CDS comments were updated in January 2008. This is a reference genome for the Human Microbiome Project. This project is co-owned with the Human Microbiome Project DACC. Product names were updated in August 2012. FEATURES Location/Qualifiers source 1..10317 /organism="Bacteroides ovatus ATCC 8483" /mol_type="genomic DNA" /strain="ATCC 8483" /type_material="type strain of Bacteroides ovatus" /db_xref="ATCC:8483" /db_xref="taxon:411476" gene complement(1..1113) /locus_tag="BACOVA_05488" CDS complement(1..1113) /locus_tag="BACOVA_05488" /EC_number="3.2.-.-" /inference="protein motif:Gene3D:IPR013781" /inference="protein motif:HMMPfam:IPR011683" /inference="similar to AA sequence:REFSEQ:YP_001037824.1" /note="KEGG: bth:BT4668 1.0e-81 arabinogalactan endo-1,4-beta-galactosidase K01224; COG: COG3867 Arabinogalactan endo-1,4-beta-galactosidase" /codon_start=1 /transl_table=11 /product="GH53" /protein_id="EDO09625.1" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR013781" /translation="MIINFNRITMIRKYIMIASALLCGSIFTACDDDNDTPTFPEKTET TYDMSGFARGADVSWLSEMESSGYKFYTSDGKEQECMSLLRDLGINAIRLRVWVNPEND TEDVKGWCNKGDVLLKAWRAHNLGYRLMIDFHYSDRWADPVQQAKPKAWENYTVEELEQ AIADHTKDVLGAIKEMGIDVEWVQVGNETHQGMLFPTGQTTSSDGIKNFAKFINSGYNA VKEIYPNAKVIVHLDQGNDANLYNRIFGYLHDNNAKWDVIGMSLYPDMYPTEGAADDWE DMNNKCIANMKSLIAKYNTPVMMCEIGIPWDYSEAEDFFTDFMTKAKQVEQCLGVFSWE PQSYGGWKNYGKGIFDDSGKPTSAFNAFKR" gene complement(1132..2886) /locus_tag="BACOVA_05489" CDS complement(1132..2886) /locus_tag="BACOVA_05489" /inference="protein motif:superfamily:IPR011050" /inference="similar to AA sequence:REFSEQ:NP_813580.1" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="EDO09626.1" /db_xref="InterPro:IPR011050" /translation="MKKLNNLFTLLSALLLLGACEKDGDTYFLSSPEENELIASANSVV LTKETAKFYALSLAWTDQTLQVSDPRYQPTTGVQTSVQVSRTEDFSGQILETTESGVSK TYSVSALNIVAYQLKATPEEEAPLYFRLAGRNGSNIAPVYSNVVKVMVTPYEIDMRFAN IINKGDGKDSGKDLYAANADGNYIGFMGATSWEGFYLQEADGTVWHTAKSGSTATPFFL TTDAAEGTWDLWFPGQSGCYYTNVNTTKKLWTALWMPTLNVSGIDGGITMEYKRDKNQW QGIFTATGAGTINIQMNGTGKLYDNTSVSGADNSIDDTKAKDTPFAFSGSANELTFNTG TNVSAGNITVNVPAAGECTLIIDLNDPQAWKVEVTEGGSVEPTYPSYLEMQGADSWWGK LYRKLEPGKTAGTYRTVFQTVSNENFQIVDPSTDTWYGSDPNNLYSLALTTGEHYNIWF DGSGKKSYTIEVDYVNLTWKPTEIKQINVYGTFNGWSTAKDLMIYDEETGIWSAECDIT TIGDGFYFLMNTDPDQISWDWRLYYTSESGLYLSDQNGDNIKPTKEGKYRITLDLNKME FTMTEITE" gene complement(2910..4490) /locus_tag="BACOVA_05490" CDS complement(2910..4490) /locus_tag="BACOVA_05490" /inference="protein motif:HMMPfam:IPR012944" /inference="similar to AA sequence:INSD:AAO79775.1" /note="COG: NOG27516 non supervised orthologous group" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q8A1G2|8.A.46.1.1" /protein_id="EDO09627.1" /db_xref="InterPro:IPR012944" /translation="MKKIFYTALYFCSALLMSSCIGDLDQYPHEEETSSTIYTSAANYK AVLGKIYAAMVTTGQEKNGDNDLSSNSGQDYMRCFFNLQECGTDEVASTWLSGDNVTGL TYLSWDANDPWVSDMYYRIYYNIALCNEFLRNATDEKIAQFTDQEQTEIRIYRAEARFM RALFYYHALDLFRNIPFVTENDPLVGYLPPRYTAQQIFDYIESELNAIKDEMLNKANCP YGRASQGAAYTLLAKLYLNAEVYTQTSKYNECIKACKKVIEQGYQLESDYYKLFNADND KRTNEIIFTLPVDATNLVSWGSSTYIVCGAVSNTSEKQIPEDYGVKSGWGMFRVRGEIP QLFSGNEEADQRYMFFTDGQTRDLEKIDDQSNGYFVEKWTNLTDAGQTASNTADGGVNT DYPLFRLADVYLMMAEAVVRGGTEATLANVLPYINELQERAFGDNTHNKSESEINELFI INERARELYWEGYRRTDLIRFNQFTTNSYVWQWKGGVKDGKAVESKYNIYPIPATELTA NPNLYNENY" gene complement(4509..7484) /locus_tag="BACOVA_05491" CDS complement(4509..7484) /locus_tag="BACOVA_05491" /inference="protein motif:HMMPfam:IPR000531" /inference="protein motif:HMMPfam:IPR012910" /inference="protein motif:ScanRegExp:IPR002048" /inference="protein motif:superfamily:IPR000627" /inference="protein motif:superfamily:IPR008969" /note="COG: NOG06412 non supervised orthologous group; Psort location: OuterMembrane, score:9.52" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q45780|1.B.14.6.1" /protein_id="EDO09628.1" /db_xref="InterPro:IPR000531" /db_xref="InterPro:IPR000627" /db_xref="InterPro:IPR002048" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR012910" /translation="MNRNILNLRHLTVLLMLCTAFLGGIIPAFAQQGGKKITGQVIDEN KEPMIGVSILIVGTSTGTVTDFDGNYTLNVPQGSKELQFSYVGYETKVVPVPANSTTLN IQLKSDSQVLSDVVVIGYGTQRKSDLTGSVTNVSSKDFNMGLVSSPEQLINGKISGVQI MSNSGSPTAGSTIRVRGGASLNASNDPLIVLDGVPLEQGGISGNDGNFLSLINPNDIES MTILKDASSTAIYGSRASNGVILITTKKGSSDKLKITFSTTNSVQTRTKLADMLSYDEF VNTIQSKGTDAQRALLGTTHTDWNDEIYQNAFGTDNNLSVAGKITKNLPFRASIGYYNQ SGLLRTDNAERYTGSITLNPSFFKDHLKLNINAKGSINKNTFANTSAIWAASTMNPTIP VYSGLDTFGGYTEAIDNTGAPVNGAVMNPVGLLNMNDSQSTVKRFIGNIDADYRLHFFP DLKLHATLGYDYAQGKGSVYVPAEAAQNYTTSGLDYSYGPQKKENRLLTLYANYNKLVE SIKSSFDVTAGYDYQYWKSTTPLYSEMNTLGEIQKTSKASDERHVLLSYYGRLNYSFNS RYMLTTTVRRDATSRFAKNVRWGTFPSVALGWRVTEESFLKDNKVISTLKVRASYGVTG QQDGIGNYNYLPIYTISQSGAGSLIGDTPTPTYRPKAYVPNLKWETTTSWNMGFDFGFL KDRITGSFDYYTRQTKDLIATVPAAAGTTFDRNITTNVGNVDSQGVEFSLNATPIQTKD WNWDLSFNMTWQKMKVKNLSLTAGTPATNTSVGPYIDSYQVQTLSEGYAPYMFYVYHQL YDEKTGKPIEGAYVDLDGDGQINSNDLYRYHSPAPDYILGFSTSLRYKKWTLSTSLRAN IGNYVYNAMAMNSGAWETVSYNSYQLNNLSSTYLKTGFQTRQYLSDYYVENASFLKMDN LSLGYNFGTIYKGCSLNVSAMVQNVFCITKYSGVDPEIPDGVDNSFYPRPRTFSLNIGI NF" gene 7594..7701 /locus_tag="BACOVA_05492" CDS 7594..7701 /locus_tag="BACOVA_05492" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="EDO09629.1" /translation="MVQTKDLFLTEEDLVPHRGTTLSSPRNKGFDNGEL" gene complement(7708..10317) /locus_tag="BACOVA_05493" CDS complement(7708..10317) /locus_tag="BACOVA_05493" /inference="protein motif:Gene3D:IPR013781" /inference="protein motif:HMMPfam:IPR001547" /inference="similar to AA sequence:INSD:CAL67108.1" /note="COG: COG3934 Endo-beta-mannanase" /codon_start=1 /transl_table=11 /product="GH147" /protein_id="EDO09630.1" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR013781" /translation="MKRLLILTFICLISAFVKVQGKSSSTPIIYIDGNGVMRWSDTRRE ASFFGVNYTLPFAHAYRAIGYLELDRKAAIDKDVYHISRLGLNAYRIHLWDVELTDGQG NLLENEHLDLMDYLIAKLKERNIHIVITAQTNFGNGYPERNIQTGGFSYKYDKCDMHSH PEAIAAQETYLHGLVKHVNPYTGLAYKDDPSIVGFEINNEPCHSGTKKEVKAYINRMLK AINKTGNRKPVFYNVSHNGYVVEAYYETAIQGTTYQWYPIGLVSGQTQQGNFLPYIDRY DIPFSDKVKGFDKKTRMVYEFDPADIMYSYMYPAMVRTFRTAGFQWITQFAYDPMDIAY ANTEYQTHFLNLAYTPHKAISMKIAAEAARSLKRGESYGSYPQDTLFGDGFRVSYTEDL SELNNGKKFYYSNHTNTQPKDASQLVSIAGCGSSPIIHYEGTGAYFMDCLEPGVWRLEV MPDAVVVNDPFAKPSLDKEVVTIAYGAWDMALQIPDLGMEFTFTALNQGNQQKGDVTDG IIRGLRPGTYLLKRKNCTPKQNWQADSQWNSIRIGEYVAPAPRVTDYKVVHTPSATTEA NKDLTISAQVVGTEFPDSVIIYTDKISFWNEHNPYIKMKRTGGYTYQATIPATEIKDDC FRYNIIVCRGNSTRTYPTGNSGYRNSSLGIKGNPLDWNYTSGAYWTTRVVAPDSAIPLL TITDADSRIEAYTLPEWNDLQRTLVDSSPVEKPLLRFRFTPKGENPHYFLRTFVKNLIE ERKERVKDCSVLCIRVNRTKALPEGFSAGFVTSDGYTYKSPCPAPSSEGIIRIPLKDLR QTDTALLPIAYPTFLKQYFHPETEIAFLPERIEKLELSMSGNKKGLVEIELGNIWLE" ORIGIN 1 ttatctcttg aaagcattaa atgcgctggt gggtttacca ctatcatcaa aaatgccctt 61 tccatagttc ttccaaccac cataactctg cggttcccag gagaatacac caaggcattg 121 ttccacttgt ttggctttcg tcataaagtc tgtgaaaaag tcttcagctt cggaatagtc 181 ccagggaata ccaatttcgc acatcatcac cggagtgttg tatttggcaa tcagactttt 241 catattggca atacatttgt tgttcatatc ttcccaatca tcggctgctc cctctgtcgg 301 gtacatatcc ggataaagag acataccgat gacgtcccat ttggcattgt tgtcatgcaa 361 ataaccgaaa atccggttgt atagattggc atcatttccc tggtcgaggt gtacaatcac 421 tttcgcattc ggataaatct ctttaacagc attgtagccg gagttaatga atttcgcaaa 481 gtttttaata ccgtcactac tcgttgtttg tccagtgggg aatagcattc cctgatgagt 541 ctcattgcct acttgcaccc attccacgtc aatgcccatc tctttgattg caccgagtac 601 atctttggta tggtcggcaa tcgcctgttc cagttcttct accgtatagt tttcccaggc 661 tttgggtttg gcttgttgaa caggatcggc ccatctgtca ctgtaatgga agtcgatcat 721 caggcgatag cccaaattat gcgctctcca tgctttgagc aatacgtcac ccttattgca 781 ccagcctttt acatcttccg tgtcattttc cgggttcacc catacacgta gacgaattgc 841 atttataccc aggtcgcgaa gcagagacat acattcctgt tcttttccat cggaggtata 901 gaatttatat ccggaacttt ccatttccga cagccaactg acatcagctc cccgggcgaa 961 gccggacata tcataagtgg tttccgtctt ttccggaaaa gtcggagtat cattatcatc 1021 atcacaagcg gtgaagatgc ttccgcaaag tagtgcggaa gctatcatta tatattttcg 1081 tatcatagtg attctgttga aattaataat catgttgttg aacttagaat gttattcagt 1141 gatttcagtc attgtaaact ccatcttgtt gagatccagc gtaatgcgat atttaccctc 1201 cttagtgggt ttaatgttat caccattctg atcacttaga tagagcccac tttcagaagt 1261 atagtacaat ctccagtccc agctaatctg atcgggatcc gtattcatga ggaagtagaa 1321 tccgtcaccg atggtggtga tatcgcattc tgcgctccat attccggttt cctcatcata 1381 tatcatcagg tctttagccg ttgaccagcc attgaaagtt ccatatacat tgatttgttt 1441 gatttcagta ggcttccagg ttaagttgac ataatctact tcgattgtat aacttttctt 1501 gccggaacca tcgaaccaga tgttgtaatg ctctcctgtt gtaagagcaa ggctataaag 1561 attgttggga tcagagccat accatgtgtc tgttgatggg tctactatct ggaagttttc 1621 attgctgacg gtttggaata cagtgcgata agttcccgca gttttaccgg gttcaagttt 1681 gcggtataac tttccccacc atgagtcggc accttgcatt tccagataag agggataagt 1741 cggttctaca cttcctcctt ccgtcacttc cactttccat gcttgcgggt cgttcaggtc 1801 aataatcaat gtacattctc cggctgctgg tacgtttact gtaatatttc cggcagaaac 1861 attcgtcccg gtattgaatg tcaattcatt agcagaacca ctaaaggcga aaggagtatc 1921 tttggctttc gtatcatcaa tgctgttatc agctccgctg acgctggtgt tatcatatag 1981 tttacctgtt ccattcatct gaatattgat agtgccggct cctgtagcag taaatatgcc 2041 ctgccattga ttcttgtcac gtttgtattc catcgtgata cctccgtcga tgccacttac 2101 attgagtgtt ggcatccata aggcagtcca tagttttttg gtggtattga cattcgtata 2161 gtaacagccc gattgaccgg ggaaccacaa atcccacgtt ccttcagcag cgtcagttgt 2221 caggaagaac ggagtagccg tactgcccga tttggctgtg tgccaaacag taccatcggc 2281 ttcctgtaga tagaaacctt cccaagaagt ggctcccata aagccgatat agttgccatc 2341 cgcattggct gcatacagat cttttcctga atccttgccg tctcccttat tgataatatt 2401 ggcaaatcgc atatcaattt cataaggagt aaccatgact tttaccacat tactgtatac 2461 aggagcgatg ttacttccgt ttcttccggc aagccggaaa tagagcggcg cttcttcttc 2521 gggagtagct ttcaactgat aagcgacgat atttaaagcg gagacagagt acgtctttga 2581 tactccactt tcggtcgttt ccagaatctg cccggagaaa tcttccgtgc gtgaaacctg 2641 tacggaagtt tgtacaccgg tggtaggctg gtatcttgga tcgctcactt gcagcgtctg 2701 gtcagtccag gcaagcgaca aagcataaaa cttggctgtc tcctttgtca gtacgacaga 2761 attggcagaa gctatcaatt cgttctcttc cgggctggag agaaaatagg tatccccatc 2821 tttctcgcaa gcacctagta ataggagggc ggaaagtaaa gtgaatagat tatttagttt 2881 tttcatatcg ttgttccgta ttaatatgat taatagtttt cattgtataa gtttggattg 2941 gccgtcagtt cggtagcagg tatcggatag atattgtatt tgctctctac tgccttaccg 3001 tcttttacgc cacctttcca ttgccataca tagctgttgg ttgtaaattg attgaagcgg 3061 atcaagtccg tacggcgata cccctcccaa tacagttcac gggcacgttc gttgatgata 3121 aacagttcgt tgatttcaga ctcgcttttg ttatgagtgt tgtcgccgaa agcacgttcc 3181 tgtagctcat tgatataagg cagtacattt gccagagtcg cttccgttcc tccacgtacc 3241 acagcttctg ccatcattaa atatacatcg gccagacgga ataggggata atctgtattt 3301 acaccaccgt ctgcggtgtt ggaagcagtc tgtccggcat cagtcaggtt agtccatttt 3361 tctacgaaat agccattgct ttggtcatct atcttttcca ggtcccgggt ttgtccgtcg 3421 gtaaagaaca tatatcgctg gtcggcttct tcgttaccgg agaaaagttg aggaatttct 3481 ccgcgtacac ggaacatacc ccatcctgat tttacaccgt aatcttccgg tatctgtttt 3541 tcggacgtgt tgctcactgc gccacaaaca atgtaagtgg atgatcccca tgacacgaga 3601 ttggttgcgt ctaccgggag ggtgaagatt atttcgttcg tacgtttgtc attgtcggca 3661 ttaaacagct tgtaataatc gctttccagt tgataaccct gttcgataac ctttttacag 3721 gctttgatac attcgttgta tttggaagtc tgggtataaa cttccgcatt cagatataat 3781 ttggcaagta atgtatatgc agctccttgg gaagcgcgtc cgtaaggaca gttcgcttta 3841 tttagcattt catctttaat ggcattcagt tcactttcaa tataatcgaa aatctgttgg 3901 gctgtatagc ggggaggcag atatccgact agcgggtcat tttccgtcac aaacgggata 3961 ttgcggaaca gatcgagtgc gtgatagtag aataaagcac gcatgaaacg ggcttcggca 4021 cgataaatac gaatttcagt ctgctcctgg tccgtgaact gtgctatctt ttcatcggtg 4081 gcattgcgga gaaactcatt acataaagca atgttgtaat agatacggta atacatatcc 4141 gatacccaag gatcattagc gtcccaactc aaatacgtca gtcccgttac gttgtcaccg 4201 gacagccagg tagaagccac ttcatccgtt ccacattcct gcaagttgaa gaaacagcgc 4261 atataatcct gtccgctgtt actactcaaa tcgttgtcac cattcttttc ctgtccggtg 4321 gtcaccatgg ctgcatagat ttttcccaga acggctttat agtttgcagc actggtatat 4381 atggtagaag atgtttcttc ttcgtgtgga tattggtcca agtcgcctat gcaggaactc 4441 atcaggagtg cgctgcaaaa ataaagggct gtataaaata tctttttcat aatcgatgct 4501 tttagtaatt agaagttaat acctatgttg agagagaaag tacgtgggcg tggataaaac 4561 gaattatcca caccgtcggg aatttccggg tcaacgccgc tgtatttggt gatacagaat 4621 acattttgca ccatggcact cacattcaga ctgcatcctt tataaatagt gccgaagttg 4681 taacccaatg agagattatc cattttcagg aaagaagcat tctctacata gtagtcagag 4741 agatattgac gtgtctggaa tcctgttttc agataggttg atgacaggtt gtttagctga 4801 taagagttat agctgacagt ttcccaggca ccgctgttca tagccatcgc attatagaca 4861 tagtttccga tattggcacg caggctggtg ctcaatgtcc acttcttgta acgcaatgag 4921 gtactgaaac cgaggatata gtcgggagcc ggagagtggt agcggtacaa gtcgttcgag 4981 ttgatttgtc cgtccccgtc aaggtctacg taagctcctt ctatcggttt gccggttttt 5041 tcatcataca gctgatggta aacgtagaac atataaggag catatccctc gctcaatgtc 5101 tgtacctgat aactgtcgat atacggacct acagaagtgt tggtggcagg cgtaccggct 5161 gtcagtgata agtttttcac tttcatcttc tgccatgtca tgttgaaact caagtcccag 5221 ttccagtcct tggtctgtat gggcgttgcg ttcagactga attccacgcc ctgactgtcc 5281 acatttccga cattggtcgt gatgttacga tcgaatgtag taccggcagc agcaggtacg 5341 gtggcaatca ggtctttggt ctgacgggtg tagtagtcga aactaccggt gatacggtct 5401 ttgaggaaac cgaaatcaaa acccatattc catgaagtgg ttgtttccca tttcaggttg 5461 ggtacatacg ctttggggcg gtaagtagga gtcggggtat ctccgataag ggaaccggca 5521 ccactttggc tgatcgtata gatagggagg tagttgtaat tgcctatacc gtcttgctgc 5581 ccggtgacac cataactggc acgcactttc agcgtactga taactttatt gtctttcagg 5641 aatgattctt ctgtcactct ccatcctaat gctactgacg ggaacgtacc ccaacgtaca 5701 tttttagcga agcgcgaagt ggcatcgcga cgtacagtag tagtcagcat atagcgggag 5761 ttgaacgagt agttcaaacg gccataataa gagagtaata catggcgttc gtcagaggct 5821 ttcgatgttt tctgtatttc tcccaacgtg ttcatttcgc tataaagcgg agtcgtggat 5881 ttccagtact gataatcgta accggctgtt acatcaaaac tactcttaat ggattccacc 5941 aatttgttgt agttggcata cagagtcaac agacggtttt cttttttctg tgggccatag 6001 ctgtaatcca aaccggaagt ggtgtaattc tgtgcagctt ctgccggaac atatacactt 6061 cctttacctt gtgcatagtc ataacctaac gtagcatgca acttcaaatc ggggaagaag 6121 tgaagacgat agtctgcatc aatgtttccg ataaaacgtt ttactgtact ttgtgagtca 6181 ttcatattga gaagtcccac cggattcatg actgctccgt tcacaggagc accggtgttg 6241 tcaattgctt ccgtatatcc gccgaatgtg tctagacccg aatatactgg aatggtagga 6301 ttcatggtcg aagcagccca aatggcactt gtattggcaa atgtgttctt attgatagaa 6361 cctttagcat tgatattcag ttttaagtgg tctttaaaga aagacggatt caatgtaatg 6421 cttccggtgt aacgctccgc gttgtcagta cgtaataaac cactctggtt gtagtaaccg 6481 atagatgcac ggaaaggtaa gtttttggta atctttccag caacacttag attattatcc 6541 gtaccgaagg cattttgata aatctcatcg ttccagtccg tatgtgtcgt gccgagtaac 6601 gcccgttgtg catcggttcc tttgctttgg atggtattga caaattcatc gtaactcaac 6661 atatctgcca atttggtacg ggtttgtaca gagttggtcg tactgaatgt aatcttcagt 6721 ttatccgaac ttcctttctt ggtagtaatc agaataaccc cgttggatgc gcgcgaacca 6781 taaatggcag tcgaagaagc atctttcaga atggtcatac tttcaatatc gttcgggttg 6841 atgaggctaa ggaaattccc gtcattaccg ctgatgcctc cctgttccaa aggaacgccg 6901 tccagtacga tcaaagggtc attactagcg ttcagtgaag caccaccacg cacacggatc 6961 gtacttcccg cagtgggaga accactgttg gacatgattt gcacaccgga aatcttacca 7021 ttaatcagtt gctcgggaga gctgaccaat cccatgttga agtccttgct gctgacgtta 7081 gttaccgaac ctgtcaggtc gcttttacgc tgcgtaccat agccgattac tacaacgtcg 7141 ctcaatacct gtgaatcact tttcaactgg atattcaaag tagtactgtt ggcaggaact 7201 ggtactacct ttgtttcata tcctacataa gagaattgca actctttgct gccttgtggc 7261 acattgagtg tataattacc gtcgaaatcg gtcactgttc cggtagaagt accgacaatg 7321 aggatactta ctccgatcat cggttccttg ttctcgtcaa tcacttgtcc ggtgattttc 7381 ttgcctcctt gttgggcgaa ggcaggaatg atgcctccta aaaaggctgt acacaacata 7441 agtagtacag tcagatggcg tagatttaag atattcctgt tcataattac tgtgttattg 7501 ataatagatt tatttttact ttttatttaa aaatcagcgg cttttctctt tctgtccctt 7561 ccgtttgcta cctcctttca gaaggcttca gacgtggttc agacgaaaga tttgtttctc 7621 accgaggaag accttgttcc tcaccgagga acgacccttt cctcaccgag gaacaaaggc 7681 ttcgacaacg gggaacttta agaatgatta ttccagccag atatttccta gttcaatctc 7741 aactaaacct ttcttgtttc ctgacattga cagctccagc ttctcaatcc tttccggtaa 7801 aaatgcgatt tccgtttccg gatggaaata ctgtttcaag aatgtcggat aagctatcgg 7861 cagcagcgcc gtgtctgtct ggcgtaaatc tttcaacggt atccgtatga ttccctccga 7921 tgatggagca ggacaagggc ttttataagt atatccgtct gacgttacga aaccggcact 7981 gaatccttcc ggaagtgctt tcgtgcgatt tacccggata cagagaacgc tacaatcctt 8041 tactctttct tttctttctt caatcaggtt ctttacgaac gtgcggagga aatagtgcgg 8101 attttctcct ttaggagtaa accggaaccg gagcaaaggt ttttccaccg gagaagaatc 8161 aaccaaagta cgttggagat cattccattc gggaagcgtg tatgcttcta tccggctatc 8221 tgcgtccgta atagtcaata gtggtatcgc actgtctggg gcaacaacac gagtagtcca 8281 ataggctccg gaagtataat tccagtccag tggatttccc tttattccca atgatgaatt 8341 cctgtaaccg gaatttcctg tgggataagt gcgagtgctg ttgccccggc atacgatgat 8401 gttatacctg aaacaatcat cctttatttc tgtagcgggt atcgttgctt gataggtata 8461 tccgcctgta cgtttcatct tgatatatgg attatgctca ttccaaaaag atatcttatc 8521 ggtgtagata atcacagaat ccgggaattc ggttcctacc acctgtgcac taatcgtcaa 8581 atccttattt gcttcagtgg ttgccgatgg agtatgaacg actttataat ccgtcacacg 8641 tggagcagga gccacatact ctccgatgcg gatggaattc cattgagagt ctgcctgcca 8701 gttctgtttg ggcgtacagt ttttacgttt cagcagatag gtacccggac gaagtccgcg 8761 gataatcccg tctgtcacat ctcctttctg ctgatttcct tgattgaggg ccgtaaaggt 8821 aaattccatc cctaaatcag gtatttgcaa agccatgtcc caagcaccat aagcgatggt 8881 aaccacttct ttatcgagtg acggtttggc aaacggatcg ttcactacta ccgcgtccgg 8941 catcacttcc agtctccaga ctcccggttc gaggcaatcc atgaaataag cacctgttcc 9001 ctcataatga atgatcggag aactgccaca accggcaatg gaaacaagtt gtgacgcatc 9061 tttgggctgg gtgttggtat gattggaata atagaatttc tttccattat ttaattcgct 9121 caagtcctct gtataactga cacgaaaacc gtcaccaaat aaagtgtcct gtggataact 9181 gccgtatgat tcacctcttt tcagactgcg tgcagcttcg gcagctatct tcatactgat 9241 ggctttatga ggcgtatagg caagattcaa gaaatgagtc tgatattccg tattggcata 9301 agcgatatcc atcggatcat acgcaaactg ggtaatccat tgaaaacctg ctgtacggaa 9361 agtgcgtacc atggccggat acatataaga atacatgata tctgccggat cgaactcata 9421 taccatccgt gttttcttat cgaatccttt cactttatcg gaaaagggaa tatcatagcg 9481 gtctatatag ggaaggaaat ttccctgctg tgtctgtcca gataccagtc cgatgggata 9541 ccattgataa gtagttccct gaatggcagt ttcgtaataa gcctctacta catatccgtt 9601 gtggcttaca ttatagaata caggtttgcg gtttcctgtt ttattgatcg ctttcagcat 9661 ccggttgata taggctttta cctctttctt cgtaccggaa tgacaaggtt cattattgat 9721 ttcgaaccca acaatggagg gatcgtcttt ataagctaac cccgtatatg gattgacgtg 9781 cttcaccaaa ccatgaagat aggtttcttg tgcagcgata gcttccgggt gggagtgcat 9841 atcgcattta tcatatttat aggagaagcc gcccgtctgt atgtttcgtt cgggatatcc 9901 gttcccgaag ttggtctgcg cggtaatcac aatatgaata ttgcgttctt tgagtttggc 9961 aatcaggtag tccatcaagt cgagatgctc gttttcgagg agatttccct gtccgtctgt 10021 cagttccaca tcccataaat gaatacggta agcattcagt cccagacggg agatatgata 10081 tacatcttta tctatggcag ctttgcggtc cagttccaaa tatccaatgg cacggtaagc 10141 atgggcgaaa ggcagcgtat aattaacacc gaaaaaggaa gcctcccggc gggtgtcact 10201 ccaacgcatc accccatttc catctatata tataataggt gtagaggatg atttgccttg 10261 cactttgaca aaggcagata tcaaacaaat aaaggtaagg atcaacagtc ttttcat //