LOCUS CP000033 14963 bp DNA linear BCT 30-JAN-2014 DEFINITION Lactobacillus acidophilus NCFM, complete genome. ACCESSION CP000033 VERSION CP000033.3 DBLINK BioProject: PRJNA82 BioSample: SAMN02603047 KEYWORDS . SOURCE Lactobacillus acidophilus NCFM ORGANISM Lactobacillus acidophilus NCFM Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 14963) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (11), 3906-3912 (2005) PUBMED 15671160 REFERENCE 2 (bases 1 to 14963) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (15-OCT-2004) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REFERENCE 3 (bases 1 to 14963) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (02-FEB-2007) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REMARK Sequence update by submitter REFERENCE 4 (bases 1 to 14963) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (01-NOV-2007) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REMARK Sequence update by submitter COMMENT On Nov 1, 2007 this sequence version replaced CP000033.2. FEATURES Location/Qualifiers source 1..14963 /organism="Lactobacillus acidophilus NCFM" /mol_type="genomic DNA" /strain="NCFM" /db_xref="taxon:272621" gene 1..940 /gene="trxB" /locus_tag="LBA0679" regulatory 1..6 /regulatory_class="ribosome_binding_site" /gene="trxB" /locus_tag="LBA0679" CDS 14..940 /gene="trxB" /locus_tag="LBA0679" /EC_number="1.8.1.9" /note="TrxB; COG0492 Thioredoxin reductase" /codon_start=1 /transl_table=11 /product="STP|Pyr_redox_2" /protein_id="AAV42555.1" /translation="MADKYDVIVIGAGPGGMTAALYATRANLNVLVLDRGPYGGQMNNT DAIDNYPGFTEVKGPELSQKMYDTLMKFEPDYKYGNVQSVELDGDEKVIKTDDEEYRAP VLIIATGADHRHLNVPGEEEYSGRGVSYCAVCDAAFFKDEDVVVVGGGDSAIEEGIYLS QMAKSVTVIHRRDQLRAQPTLQKRAFANEKMKFIWNAQTEEILGDGNRVTGVKYLDKEN GETKEVSAAGVFIYVGVLPQTEPFKKLGILNEQGWIPTNEHMETKVSGIFALGDVRDKD LRQIANAVGEGSVAGQAAYNYFQDLKN" gene 1105..3034 /gene="glgB" /locus_tag="LBA0680" regulatory 1105..1110 /regulatory_class="ribosome_binding_site" /gene="glgB" /locus_tag="LBA0680" CDS 1118..3034 /gene="glgB" /locus_tag="LBA0680" /EC_number="2.4.1.18" /note="GlgB; hypothetical protein" /codon_start=1 /transl_table=11 /product="GH13_9|CBM48|GH13" /protein_id="AAV42556.1" /translation="MVTIVEVKQHIKKFAAGNELYLQEVLGCHYENDIYTFRVWAPNAQ KVWLVGDFNDWDKSLEMSQTLDGVWEIKTSLPKEGQLYKFLVKQADGREVMKIDPMAFE LEPRPGSAAVIVKLPNKKWLDGAWMGRNKRSNHFARPINIYEVHASSWKRHTDGSLYTL KDLQKELIPYVKEQGFNYIEFLPLTAHPLDASWGYQTIGYYALERTYGTPRELQDFVEA CHKENIGVLADWVPGHFCINDDALAYYDGTPCYEFSEKWRAENKGWGALNFDLGKPEVQ SFLLSSALFWLEFYHLDGLRVDAVSNMIYRDYDRSDGEWKTDKFGGNRNLEGIEFLQKL NRTIKGKHPECLMIAEESSAQVKITGRIEDGGLGFDFKWNMGWMNDILRFYEMDPLFRK FNFNLATFSFMYRMSENFILPLSHDEVVHGKRSLMNKMFGDRDKQFAQLRNLLTLQMTY PGKKLLFMGSEFGQYLEWRYNDGLDWAELKDELNAKMKHFDQDLNSFYLNEPALWQLEQ REDSVQIIDADNKDESVLSFIRQGKTRHDFLIVILNFTPVDRKKITIGVPYAGKYCEVF NSARKEYGGSWNQEKQNLKTQNNSFKNFNYQVQLDIPGFSAVILKPVDVHIKRRINRKT KTK" gene 3037..4195 /gene="glgC" /locus_tag="LBA0681" regulatory 3037..3043 /regulatory_class="ribosome_binding_site" /gene="glgC" /locus_tag="LBA0681" CDS 3050..4195 /gene="glgC" /locus_tag="LBA0681" /EC_number="2.7.7.27" /note="GlgC" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase" /protein_id="AAV42557.1" /translation="MSTEMLGLILAGGKGTRLGKLTSDQAKPAVPFGGRYRIIDFTLSN CANSGVKNIGIITQYQPLLLNEHIGNGVSWGLDGLNASATILQPYTDNSGSKWFEGTAH AIYQNIDYIDSKDPEYVLILSGDHIYKMDYESMLEEHIKNGASLTVAVIDVPMKEASRF GIMNTDVSGRITEFEEKPEHPKSNHASMGIYIFNWKRLREVLTTGFTTNDDMVDFGKNV IPYYLKSDERVFAYHFSGYWKDVGTIDSLWAANMEFLDGSDGLNLYDRSWRIYSKNPID PAQVITENAEVNNSMIVDGCYVDGTINHSILSTDVDVQRGSEITDSVIMPGVKIGKDVV IKHAIVGENAQIGDGAVVEGNKDNIKVIGNSERIGVLPNED" gene 4185..5327 /gene="glgD" /locus_tag="LBA0682" CDS 4185..5327 /gene="glgD" /locus_tag="LBA0682" /EC_number="2.7.7.27" /note="GlgD; Required for glycogen biosynthesis" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase" /protein_id="AAV42558.1" /translation="MKTNKMAAIFSNQHEYNELRPLTDERSLSALYFAGKYRIMDFALS SIVNAGINNVYTLISQEKVRSYLDHLGGGKEWGLDTIGSYAYLDFYQKLLQSQANGGEY FNDLITFLATANAPYTVFLENKIVANVDLQSVLHFHQENGNRITAVFKRVSKKNVAPDD QLYILDEENTIMSCQQAIDTQSQDSYNLGLNIYVADTKWLIAELKKAQKCGAPIDIGQR FASLAAKYRTNAYEYTGYLHNVHDIKSYYDSNIEMLDKKNRDSLLHGNQRIITRIRNEV GTYYTTSSKVKNSLFATGCRINGTVENSILSRRIDVAEDSNVKNSIVMASCTLEAGSSV EYAILDKNVVIKKDVVVKGTPDNPVVIKKGDVVTKDLIVE" gene 5327..6767 /locus_tag="LBA0683" regulatory 5327..5332 /regulatory_class="ribosome_binding_site" /locus_tag="LBA0683" CDS 5337..6767 /locus_tag="LBA0683" /EC_number="2.4.1.21" /codon_start=1 /transl_table=11 /product="GT5" /protein_id="AAV42559.1" /translation="MRVLFTGAECAPFFKTGGLGDVLGSLPNQLAKEGVDVGVVLPLYQ DLPEKYRKNLKYQGNFIVPVGWRNQYCGIFTLKLNGVNYFFIDNEYYFKRPGIYGYYDD GERYAYFQQAVIMMMERFDFIPDVLHCNDYHTAFIPFLLHEKWGFVDAYKGIKTILTIH NLEFQGKYNAKTLPDFFGMNYDWFDSGIVRMDNDVNWMKTGILYADRVTTVSPSYAREI QTVEFGQGLDAILRMCSHKLTGILNGIDFEKYNPKTDPVIKKNYDVYHLHHKSKDKIAL QKELDLPIKPNIPLIGMVSRLTAQKGCQLLLDELDNILQFNVQIVILGNGDPYYEHRLM EIAERYPDKLKVILAFDVKLAQRIYAGADSFLMPSAFEPCGLSQLIALRYGTLPIVHEI GGLADTVWVYDETTNEGTGFGFKEFSGYQMVQAIKKMLALYQQKNNWLKIQKIAMKSDF SWKNSADKYKWMYGELIG" gene 6786..9197 /locus_tag="LBA0685" CDS 6786..9197 /locus_tag="LBA0685" /EC_number="2.4.1.1" /codon_start=1 /transl_table=11 /product="GT35" /protein_id="AAV42560.1" /translation="MQLTKDEFKKKLKNKVNIYFEEELDEASNSELYTALSGVVRDGYA PQWRRTRISEADQGQKQVYYFSIEFLPGTLLKTNLLNLGWLDTVRAALSDLGLDLDKIA AAEPDMALGNGGLGRLAAAFMDSLASTGYTGNGNGIRYKYGLFKQKFVNGYQKELPNDW LKKDDHWEVRRESKSVLVRFGGKVRMVDDNGWMTPQYEGGDVVRAVPYDTAIVGYRDGV TNTLRLWDAEIPPEEELSYPTISDRRRIEDLTSILYPDDSNYEGRLLRLKQEYFFVSAG LQSILDYYVKKLGNKDFTKLPDYVAVHINDTHPAMAIAELMRLLVDEHRVDWETAWDIT LKVMSYTNHTIMSEAMEKWDTNMLSQLLPRIMQIITEIDRRYCAYLNGQVSNDVIERTR IIKNGQVQMAHLAIIGSHSINGVAALHTQLLETKVLKDFYNLYPDRFNNKTNGITLRRW LQIANPELSDLLDQTIGKDWRKNSDKMLNFEKYYNDTLVLERINQIKLDNKKKLAEFIK EQMGVEVDPNAIFDVQVKRLHEYKRQTLKLLHILKLYQDLKAGIDHPKRVVIFGAKAAP SYVFAKQVIKVINETANMINSDPDINGKLKVIFLENYDVSLAEKIIPAADVSEQISTTT KEASGTSNMKLMANGALTVATMDGANIEIADAVGEDNIITFGLNKDQVYKYYAEHSYHP REMYESDPVMKKTVDALTDGTIPNCFSEGQALANKFLSDNEQFFVLADFADYLKAQEKV EQEWKDKHSWAQMSLVNIAHSERFDVDKTIERYAQDIWHLKKLKVEKVDH" gene 9197..10966 /locus_tag="LBA0686" CDS 9197..10966 /locus_tag="LBA0686" /EC_number="3.2.1.41" /codon_start=1 /transl_table=11 /product="GH13_39|CBM34|GH13" /protein_id="AAV42561.1" /translation="MKITYDSWQEQYKNPFGAVKAGNTVKWSIKIDQVIQGAVLWLTKS RETPVAYPMNYDEQTKMYTTQVKIGTSGLYNYYFALQQNNQIVYIDQGLFGKGHVTKSD HDLRQFQLTCYDIATPRIDWYQKGIVYQIFPDRFANGNPYEEVIGKKRNSFIYATKEDI PYYIKNSEGAIVRWDFFGGNLTGIRKKIPYLKQLGVTVLYLNPIFLAKSNHRYDTTDFM KIDPMLGDEKDLADLIRELHENNMHLILDGVFNHVGFDSIYFQGAITDKNSNYRSWFNF QDYPNKYQSWWGVKSLPTVNKDNSEYQNLVYGDHGVLAKWKVDGWRLDVADELPMDFLR NIRNRLIKENCPILIGEVWEDASNKFVNGEYRTYTAGDNLMGVMNYPIRNFIISLLSAQ DSTIEIEAMNDLALLIENYPTDFLHNCLNNIGTHDTVRIKTVLNKNDNLVMMAFGLLFM MPGVPCIYYGDEAGLIGKEDPDNRRYFLWGHEDKKLIDCVSSWTKIRKQNPVLVNGKIG FVHLSAGVNSIVRYNDQEMIMYCVNCTNEDVIPLREKYSFYWLPSIIIDKIKDTLDQIQ LKAQTDFIKKISL" gene 11074..12809 /locus_tag="LBA0687" regulatory 11074..11080 /regulatory_class="ribosome_binding_site" /locus_tag="LBA0687" CDS 11085..12809 /locus_tag="LBA0687" /EC_number="5.4.2.2" /note="COG1109 Phosphomannomutase" /codon_start=1 /transl_table=11 /product="phosphoglucomutase" /protein_id="AAV42562.1" /translation="MEAKEIFKEWQNATGLPDYLKDQLDTLGKDEKWIEDAFGQDINFG TAGMRGRLEPGTNRINLFTVGRVTEGLARLIDENGEEAKKRGVVIAFDSRYHSREFAEH AARVLGAHGIHVYLFDDLRPTPELSYAVRHLNTFAGINITASHNAKQYNGYKVYGEDGA QMAPENADRLFAYAQKVTDIFGVEVASVKELRANNTLQLIGEDVDEAYLNELKQVTVDK EMVKANADKLKIIYTPLHGTGKMLYDRAFRQGGFDNVIPVPSQSIIDPEFPTTIKPNPE YRDVFEPGFKLADKVDANVIIATDPDADRMGAAVRKSDGDFQVLTGNQIATLMAYYLLA HLKESGKLTDDYEIVTSVVSSALPFKIAEDFGIKTKHVLTGFKYIGEEVDRMNKAGDAK FLMGFEESYGYLFKPFARDKDAMQGALMFAEVASYYASRGMTVFDGLQEIWKKYGVAYE ITRAIEMPGIGGQKKMAELMSKLRNEHLTEIGGSKVVKIQDFLKQETIENGEKTPLEGF PESNVLKYFLDDETWVALRPSGTEPVIKAYVGVNKENIEKAEKAAEDYQTALANLLK" gene 12897..14963 /gene="uvrB" /locus_tag="LBA0688" regulatory 12897..12904 /regulatory_class="ribosome_binding_site" /gene="uvrB" /locus_tag="LBA0688" CDS 12912..14963 /gene="uvrB" /locus_tag="LBA0688" /note="UvrB" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="AAV42563.1" /translation="MIKRQKDRKFELVSKFKPAGDQQQAINKLTAGFEKGYKEQILEGA TGTGKTFTMANIIAKLNKPTLVITHNKTLVGQLYGEFKGFFPNNAVEYFVSYYDYYQPE AYVPQSDTYIEKDSAINDEIDQLRHATTSALMERNDVIVVASVSCIYGLGDPKEYARSV LMIHEGQEYERNTLLRDLVNLQYDRNDIDFQRGRFRVRGDVVEIFPAGNSNHAYRVEFF GDEIDRIVEIDSLTGEVIGERESISLFPATHFMTNDEQLRRALKAISKEMKVQVKKFEG EGKLLEAERIKQRTTYDMEMMGEVGYTNGIENYSRHMEGRKVGEPPYTLLDFFPDDFLI LIDESHATMPEIRAMYNGDRNRKKTLIDYGFRLPSALDNRPLKLAEFEKHVNQILYVSA TPGDYELERTDHKVEQIIRPTGLLDPKIEVRPIEGQIDDLVGEINKRIDRNERVFVTTL TKKMAEDLTDYLKDLGIKVRYLHSDIKTLERMQILRDLRLGKFDVLIGINLLREGIDVP EVSLVAILDADKEGFLRAYRPLVQTMGRAARNANGEVIMYADTITDSMKAAIEATQRRR KLQEEFNKEHGIVPKTIIKPVHDVISITKPSEDSKKEKTDSFADLNFDELTAKQKKTMI KNLQEQMKEAAKKLDFEEAANLRDAIMELQSSSRRPKTRKGKALNGKR" gene 14950..>14963 /gene="uvrA" /locus_tag="LBA0689" CDS 14950..>14963 /gene="uvrA" /locus_tag="LBA0689" /note="UvrA" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|A9WBR9|3.A.1.32.3" /protein_id="AAV42564.1" /translation="MVNDKIVVRGAREHNLKDIDLTIPKDKLVVITGLSGSGKSSLAFD TLYAEGRRRYVQSLSSYARQFLGQMDKPDVDSIDGLNPAISIDQKTTSHNPRSTVGTVT EINDYLRLLWARVGHPVCPNDGTLIERQSVDQMVDRIMGLPERTKIQLLAPVVRAKRGE HKEVFKRIQRAGYVRVIVDGEMHEIGEEFNLEKNKRHSIDIVVDRLIVKDSIRSRLFDS TEAALRLSDGYMNVDVIDGKMLNFSEDYACPKCGFTVGEMEPRLFSFNAPFGACPDCDG LGMKLEVDEDLVVPDKSLTLEEGALAPWKTSNYYSEMLKQACDALGIPMDKPFNKLTKK QKDIILHGSTKPVKFNITGDFGVNATTQPFEGVMTNVERRYRRPMSKFMRDVMGKYMTE LTCSTCHGKRLNEKALAVKVMGKDIAQASDLSIKKALDFFSNIELSEQETIIAKPVLKE VRDRLSFLDSVGLDYLTLSRTANTLSGGEAQRIRLATQIGSNLSGVMYVLDEPSIGLHQ RDNDRLIASLKRMRDLGNSLIVVEHDDETMRQADYLVDMGPGAGVYGGKVMAQGTPEEV EKDPNSLTGQYLSGKKFVPVPLKRRKGNGKKITITGATENNLKDIDVSFPLGKFIVVSG VSGSGKSTLVNMILKRALAQKLNNNSTKPGKYKSIRGYKNIEKIIDIDQSPIGRTPRSN PATYTSVFDDIRTLFAQTNEAKMRGYTKARFSFNVKGGRCEACHGDGIIKIEMNFLPDV YVPCEVCHGTRYNSETLEVTYREKNIAQVLDMTINEACKFFENIPKIERKLKTIVDVGL GYVKLGQSATTLSGGEAQRMKLAAELQKLSTGKNFYILDEPTTGLHTDDIKRLLEVLQR LVDEGNTVLIIEHNLDVIKNADWLIDLGPEGGEGGGTIVATGTPEEVAEVRESYTGQYL KPVLRRDILLTKRAQK" ORIGIN 1 aggagcggcg aatatggccg ataaatatga cgtaattgta attggcgctg gaccaggtgg 61 tatgacagcg gctttatatg ctacccgtgc taatttaaat gtattggtgc ttgatcgtgg 121 accatacggt ggtcaaatga acaatactga tgcaattgat aattatccag gctttactga 181 agttaaagga ccagaactta gtcaaaagat gtatgatact ttaatgaagt ttgaacctga 241 ttataaatac ggtaatgtac aatcagttga attagatgga gacgaaaaag ttattaagac 301 tgacgatgaa gaatatcgcg ctccagtctt aattatcgct actggtgcag atcatagaca 361 cttgaatgtt ccaggtgaag aggaatactc aggtagagga gtttcttatt gtgctgtttg 421 tgatgctgca ttttttaagg atgaagatgt ggttgtagtg ggtggcggtg attccgctat 481 cgaagaagga atttatcttt ctcaaatggc caagagcgta actgttattc accgtcgtga 541 tcaattacgt gctcagccta ctttgcaaaa acgtgcattt gcaaatgaaa aaatgaagtt 601 catttggaat gctcaaacag aagaaattct aggtgatggt aatcgtgtaa ccggtgttaa 661 gtatctagat aaagaaaatg gagaaactaa agaagtttct gctgcaggtg tatttattta 721 tgtgggtgtg ttaccacaaa ctgaaccatt taaaaaacta ggtattttaa atgaacaagg 781 ttggattcca actaatgagc acatggaaac aaaagtatca ggtatttttg ctttaggtga 841 tgttcgtgat aaagatttgc gtcaaattgc taatgcggtt ggtgaaggta gtgtagcggg 901 gcaggctgca tataattatt ttcaagattt aaaaaactga tataaaaatt aaaaatttta 961 aaaataagac catattttat taataaatat ggtcttattt ttttactata catagataag 1021 tgatatataa ttaaaagtaa aggagaatct tatttataat caaagtaagc gctttccgct 1081 ttttgtaaac tgtaattttg attttggaga aagcagtatg gtaacgatag tggaggttaa 1141 acaacatatt aaaaaatttg cagctggcaa tgagctatat cttcaagaag tattagggtg 1201 tcattatgaa aatgatatct atacttttag agtatgggca ccaaatgcgc aaaaagtttg 1261 gctagttggc gattttaatg attgggataa atcattagaa atgagtcaga ctttagatgg 1321 agtttgggaa ataaagacca gcttacccaa agaaggacag ctatataagt ttctagttaa 1381 acaagctgat ggtcgtgagg taatgaaaat tgatcctatg gcgttcgaat tagagcctag 1441 accaggcagt gcagctgtga ttgttaagtt acctaataaa aagtggcttg acggtgcatg 1501 gatgggacga aataaaagat cgaatcattt tgctcgacca attaatattt atgaagtaca 1561 tgctagttca tggaaaagac atacagatgg gtctctgtat actttgaagg atttacaaaa 1621 ggaattaatt ccgtatgtta aagaacaagg atttaattat atcgaatttt tgcctttaac 1681 agcacatcct ttagatgctt catggggata tcaaacaatt ggttattatg ctttggagcg 1741 tacttatggt acaccacgag agctgcaaga ttttgttgaa gcatgtcaca aagaaaacat 1801 cggtgttttg gctgattggg taccaggaca cttttgtatt aatgatgatg ccttggctta 1861 ttatgatggc acaccatgtt atgaatttag cgaaaaatgg agagccgaaa ataaaggctg 1921 gggagctcta aattttgatt taggcaaacc ggaagtgcaa tcatttttac tttctagtgc 1981 cctattttgg ctagaatttt atcatttgga tggcttgaga gttgatgctg tttctaacat 2041 gatttatcgc gattatgacc gcagtgacgg tgaatggaaa acagataaat ttggtggaaa 2101 tcgtaattta gaggggatag aattcctaca aaaactaaat cgaaccatta aaggcaaaca 2161 tccagaatgt ttaatgattg ccgaggaaag ttctgctcaa gtaaagataa ctggtcgaat 2221 agaagatggt gggttaggtt ttgattttaa atggaatatg ggttggatga acgatatttt 2281 acgtttttat gagatggacc cattatttag aaaatttaat tttaatctag ctactttttc 2341 attcatgtat cgaatgagtg aaaactttat tttaccttta tcacatgacg aggttgttca 2401 tggtaagcga agcctaatga ataaaatgtt tggcgaccgt gataagcaat ttgctcaatt 2461 acgtaattta cttacattgc aaatgaccta tcctggtaaa aagcttttat ttatgggaag 2521 tgaatttgga caatatcttg aatggcgata taacgatggc ttagattggg cagaattaaa 2581 ggatgaactg aatgctaaaa tgaagcattt tgatcaagat ttaaatagtt tttatttaaa 2641 tgagccggct ttgtggcaat tagaacaaag agaagattct gttcaaatta ttgacgcaga 2701 taataaagat gagtcagtct tgtcatttat tcgtcaaggt aaaactagac atgacttttt 2761 aatagttatt ttgaatttta cacctgttga tcgaaaaaaa attacaattg gtgttccata 2821 tgctggtaaa tattgtgaag tctttaatag tgccagaaaa gaatatggtg gcagttggaa 2881 ccaagaaaag cagaatttga aaactcaaaa taattcattt aagaatttta attatcaagt 2941 gcaattggat ataccgggtt ttagtgctgt gattttaaaa cctgtagatg ttcatataaa 3001 aagaagaatt aatagaaaaa caaaaactaa gtaataagga gaaaaaacaa tgagtaccga 3061 aatgttgggc ttgattttgg caggaggaaa aggaacaaga ttaggtaaat taaccagtga 3121 tcaagcaaaa ccagctgtcc cttttggtgg ccgatataga attattgatt ttactttaag 3181 taattgtgct aattctggtg taaaaaatat aggaatcatt acacaatatc aaccattatt 3241 gcttaatgag catattggta atggagtaag ctggggatta gatggattaa atgcaagtgc 3301 cacaatctta caaccatata ctgacaattc tggtagtaaa tggtttgagg gcacggctca 3361 tgccatttat caaaatattg attatattga tagtaaggat ccagaatatg tattaattct 3421 ttccggtgat catatttata aaatggatta cgaatctatg ttggaagaac atattaagaa 3481 cggtgcgtca ttgaccgtag ctgtaattga tgttcctatg aaagaagcat ctcgttttgg 3541 aattatgaat acggatgtta gtggtagaat tacagaattt gaagaaaagc ctgagcatcc 3601 aaaaagtaac catgcatcaa tgggaattta catctttaat tggaagagat tgcgtgaagt 3661 tttgaccacc ggattcacta ctaatgatga tatggtggat tttggtaaaa atgttattcc 3721 atattattta aagagcgatg aaagagtatt tgcatatcat ttttctggtt attggaaaga 3781 tgtaggaact attgattcct tatgggctgc aaacatggaa tttttagatg gcagtgatgg 3841 tcttaactta tatgatcgtt cctggagaat atattctaaa aatccaattg atcctgcaca 3901 agttattact gagaatgcag aagttaacaa ttcaatgatt gtagatggat gctatgtaga 3961 tggtacgatt aatcattcga ttttatcgac agatgttgat gtacaacgtg gctctgaaat 4021 tactgattct gtgattatgc caggagtaaa aataggtaag gacgttgtta ttaagcacgc 4081 gattgttggt gagaatgctc agattgggga cggagctgta gttgagggga ataaagataa 4141 cattaaagtg ataggtaatt cagaaagaat tggagtattg ccaaatgaag actaataaaa 4201 tggctgcaat ttttagtaat caacatgagt ataatgaatt acgcccgttg actgacgaac 4261 gttcattatc tgctttatat ttcgcaggta aatatcgcat tatggatttt gctctttcaa 4321 gtattgtaaa tgcaggaatt aataatgtgt ataccctgat tagtcaagaa aaagtaagat 4381 catatcttga tcatttaggc ggaggcaaag aatgggggct agatactata ggctcttatg 4441 catatcttga tttttatcaa aaattattgc aaagccaagc aaatggagga gaatatttta 4501 atgatttaat taccttcttg gctacagcta atgctccata tactgttttt cttgaaaata 4561 aaatagttgc taatgttgat ttgcagtcgg tattacattt ccatcaagaa aatggaaatc 4621 gtattacagc tgtctttaaa cgtgtaagta agaaaaatgt ggcgccagat gatcagctat 4681 atattttaga cgaagaaaat accataatgt cttgccaaca agctattgat actcaaagtc 4741 aagatagcta taacttaggt ttgaatattt atgtggcaga tactaaatgg ttgattgctg 4801 aattgaagaa agcccaaaaa tgtggcgctc ctattgatat tggtcaaaga tttgcaagtc 4861 ttgcagcaaa ataccgtaca aatgcttatg aatataccgg ttatttgcat aatgtccatg 4921 acattaagag ttattacgat tccaatattg aaatgcttga taagaaaaat cgtgactcac 4981 ttttacacgg taatcaaaga attattacaa gaattagaaa tgaagtaggt acgtattaca 5041 ctacttcttc taaagttaag aattctttat ttgcaactgg ctgtagaata aatggaacag 5101 tagaaaatag tatcttatca agaagaatag atgttgctga agatagtaac gttaagaact 5161 ctattgtaat ggcaagttgt actttagaag ccggtagtag tgttgaatat gctattttag 5221 ataaaaatgt agtaataaaa aaagatgtag tagttaaggg aaccccagat aatccagtgg 5281 ttattaagaa gggtgacgtt gtaactaaag atttaattgt tgaataagga gaaatcgtgc 5341 gagttttatt tactggtgct gaatgtgcac cttttttcaa aactggggga ttgggcgatg 5401 tattaggctc tttgcctaac caattagcta aagaaggtgt tgatgttggt gtcgtccttc 5461 ctttgtatca agatttacca gaaaagtatc gtaaaaattt aaaatatcaa ggtaacttta 5521 ttgtgccagt aggttggcgt aatcaatatt gtggaatttt tactttgaaa ttaaatggtg 5581 tgaattactt ctttattgat aatgaatatt attttaagcg tccgggaatt tatggttatt 5641 atgatgatgg cgaaagatat gcttatttcc aacaagcagt catcatgatg atggagcgtt 5701 ttgattttat tccggatgtg ttgcattgca atgattatca cactgcattt attccatttt 5761 tactccatga aaaatggggc tttgtcgatg catataaagg gattaaaaca attttaacta 5821 ttcataactt agagtttcag gggaaatata atgcaaaaac tttaccggat ttctttggta 5881 tgaattacga ctggtttgat agtggtattg tccgaatgga taatgatgtt aactggatga 5941 aaaccggcat tttatatgca gaccgtgtaa ctacggttag tccatcttat gctcgtgaaa 6001 ttcaaactgt tgaattcgga caaggcttag atgcgatttt aagaatgtgt tcacataagt 6061 taactggtat tttaaatggg attgattttg aaaaatataa tcccaagact gatcccgtaa 6121 ttaagaaaaa ttatgatgtt tatcatttac atcataaatc aaaggataaa atagcacttc 6181 aaaaagaatt agatttgcca attaagccaa atattccttt aattggtatg gtttcacgtt 6241 taactgcaca aaagggctgt caattattgc ttgacgagtt agataatatt ttgcaattta 6301 atgttcagat tgtaatttta ggtaatggtg atccatatta tgaacatcgt ctaatggaaa 6361 ttgctgagcg ttatccagat aaactaaagg ttattttagc gtttgatgtt aaattggctc 6421 aaagaattta tgctggagca gatagtttct taatgccttc tgcgtttgaa ccgtgtggac 6481 tttcacagct aattgcattg cgttatggta ctttaccaat tgttcatgaa attggtgggt 6541 tagcagatac tgtttgggta tatgatgaga ctaccaatga aggtactggc tttggcttta 6601 aggaatttag tggttatcaa atggtacaag caataaagaa aatgttagcg ttgtatcaac 6661 aaaagaataa ttggcttaaa atacaaaaaa tagccatgaa atcggacttt tcatggaaaa 6721 attctgctga taagtataag tggatgtatg gagagttaat tgggtaatcc aattggtgta 6781 aaaatatgca attaacaaaa gatgaattta aaaagaaact aaaaaataag gtaaatattt 6841 attttgaaga agaacttgat gaagcatcaa atagtgagtt atacactgca ttaagtggag 6901 tggttagaga tggatatgca ccgcaatggc gtcgtacccg tatttccgaa gctgatcaag 6961 gacaaaaaca ggtttattat ttttcaattg aatttttgcc aggaacttta cttaaaacta 7021 atctgctaaa tttaggctgg ctggatactg ttagagctgc attgtcagat ttgggattag 7081 atctagacaa gattgctgca gcagaaccag atatggcttt aggtaatggc ggtctgggac 7141 gattggctgc agcttttatg gattctcttg cttcaactgg ctataccgga aatggaaatg 7201 gtattcgtta taagtatggt ttattcaagc aaaaatttgt aaatggctat caaaaagaac 7261 taccaaatga ttggcttaaa aaagacgatc attgggaagt tagaagagag agcaaatctg 7321 ttttagtaag atttggcggt aaagtacgta tggttgatga taatgggtgg atgacacctc 7381 aatatgaagg tggcgatgtt gtcagagctg taccgtatga tactgcaatt gtaggttata 7441 gagatggtgt aaccaataca ttgagattgt gggatgcaga aattccacca gaagaagaat 7501 tgtcatatcc tactatttca gatagacgtc gtatagaaga tttaacttca attttgtatc 7561 cagatgattc taattatgaa ggtagattat taagattaaa gcaagaatat ttctttgttt 7621 cagctggatt acaaagtatt ttagattatt atgttaaaaa acttggtaat aaagatttca 7681 ctaaattacc agattacgtg gctgttcata tcaatgatac gcatccagca atggcgattg 7741 cagaattgat gagattgcta gttgatgaac atcgtgtcga ttgggagact gcctgggata 7801 tcactttaaa ggtgatgagt tataccaatc atacaattat gtcagaggca atggaaaaat 7861 gggatacaaa tatgctgtct caattgttgc cgagaattat gcaaattatt actgaaatag 7921 atcgtcgtta ttgtgcttat ttaaacggac aagtctctaa tgatgtaatt gaacgtactc 7981 gaattataaa aaatggacag gtccaaatgg cgcatttagc aattattggc tcacactcaa 8041 ttaatggggt agcagcattg cacacccaat tattggaaac caaagtgtta aaagattttt 8101 ataatttata tcctgatcgc tttaataata aaactaatgg aatcactttg cgtagatggc 8161 tacaaattgc taatccagaa ttatctgatt tacttgatca aactattggt aaagattggc 8221 gtaaaaatag tgataagatg ctcaattttg aaaagtacta caacgacact ttagtattag 8281 agcgtattaa tcaaattaaa ctagataata agaaaaaact agctgagttt atcaaagaac 8341 aaatgggagt agaagttgat ccaaacgcta tctttgatgt gcaagtcaag cgactacatg 8401 aatataaacg ccagacttta aagttattac atattctaaa gttatatcaa gatttaaaag 8461 cagggattga tcatcctaag cgagtagtta tatttggggc taaagctgca ccaagctatg 8521 tatttgctaa acaagtaatt aaagtgatca atgaaacagc taatatgatc aattcagatc 8581 cagatattaa cggcaagtta aaggtaatct ttttagaaaa ttatgatgtt tctctagctg 8641 aaaaaattat tcccgcagct gatgtaagcg agcaaatttc gaccactact aaagaagcta 8701 gtggtacaag caacatgaaa ttgatggcca atggtgcttt aactgtggct acaatggatg 8761 gtgcaaatat tgaaattgcg gatgcagtag gtgaggataa tatcattacg tttggcttaa 8821 ataaggatca ggtttataaa tattatgcag aacattctta tcacccaaga gaaatgtacg 8881 aatcagatcc agtaatgaag aaaacagttg atgcgttaac tgatggtaca attcctaatt 8941 gtttttcgga aggacaagct ctagcaaata aatttttgag tgataatgag caattctttg 9001 ttttagcaga ctttgctgat tatttaaaag ctcaagagaa agtagaacaa gaatggaaag 9061 ataaacattc ttgggctcaa atgagtttgg taaatattgc tcattcagaa cgttttgatg 9121 ttgataagac aattgaacga tacgcacaag atatttggca tttaaaaaaa ttaaaagttg 9181 aaaaagttga tcactaatga aaataactta tgattcttgg caagagcagt ataaaaaccc 9241 ttttggtgct gttaaagctg gtaatacagt taaatggtca atcaaaatag atcaagtaat 9301 acaaggagct gtcttgtggt tgactaaaag tcgagaaaca ccagtggctt atccgatgaa 9361 ctatgatgaa cagactaaaa tgtataccac acaggtaaaa attggtacat ctggtttata 9421 caattactac tttgctttgc aacaaaataa tcaaatagtt tatatagatc aaggactttt 9481 tggtaaagga cacgtaacta aaagtgatca tgatttaaga cagtttcaat taacttgtta 9541 tgatattgca actccacgaa tcgattggta tcaaaagggc attgtttatc aaatttttcc 9601 ggatcgcttt gctaatggaa atccatatga agaagttata ggtaaaaaaa ggaatagttt 9661 tatctatgct actaaagaag atattccata ttatataaaa aatagtgaag gtgctatagt 9721 gcggtgggac ttttttggcg gtaatttaac tggaattaga aaaaagatcc cttatttaaa 9781 acaactaggt gttacagtcc tttatcttaa tccaattttt ttagctaaaa gtaatcatcg 9841 ctatgataca acagatttta tgaaaatcga tccaatgttg ggtgatgaaa aagatttagc 9901 tgacttaatt agggaattac atgagaataa tatgcatcta atattagatg gagtatttaa 9961 tcatgtaggt tttgatagca tttattttca aggagcgatt actgacaaaa atagtaatta 10021 tcgttcttgg ttcaactttc aagactatcc aaataaatat cagtcttggt ggggtgtaaa 10081 gtctttaccg actgttaata aagataattc tgaatatcaa aatcttgttt atggcgatca 10141 tggtgtatta gctaagtgga aagttgatgg ttggcgactt gatgtagctg atgagttacc 10201 gatggatttc ttgcgtaata ttcgtaaccg tttgataaag gaaaattgtc caattttgat 10261 tggggaagtt tgggaagatg cttcaaataa atttgtaaat ggtgaatatc gaacttatac 10321 agctggtgat aatttaatgg gggttatgaa ttatccgata cgcaatttta ttatcagttt 10381 gttatcagct caagatagta ctatagagat agaagcaatg aatgacctgg ctttactgat 10441 tgaaaattat ccaactgact ttttgcataa ttgtttaaat aatatcggta cccatgatac 10501 ggtaagaatt aaaaccgttt tgaataaaaa tgataattta gtcatgatgg cttttggctt 10561 attatttatg atgcccggag ttccatgtat ttattatggc gatgaggctg gcttaattgg 10621 taaagaagat ccagataatc gacgttactt tctatgggga catgaagata aaaagctaat 10681 agattgtgtt agcagttgga ccaaaatacg caagcaaaat ccagtattgg taaatggcaa 10741 aatcggtttt gtacatttgt cggctggggt taatagtata gttagatata atgatcaaga 10801 gatgattatg tattgcgtta attgtactaa cgaagatgtg ataccgttgc gtgaaaagta 10861 ttcattttat tggttgccga gcataattat tgataaaatc aaggatactt tggaccaaat 10921 tcaacttaaa gcacaaacag attttattaa gaaaatatcg ctatagttat ttaaattagt 10981 taaatttaag ttttataata atacgtggat aatagaaaaa tattgataat ttaaaaagac 11041 attagaaatc cataaatata cgattttaat gaatagagga aaagatggaa gctaaggaaa 11101 tttttaaaga atggcaaaat gctactgggt taccagatta tttaaaagat caattagata 11161 ctttaggtaa agatgaaaaa tggattgaag atgcctttgg tcaggatatt aattttggta 11221 ctgcaggaat gcgcggacgc cttgaaccag gtactaatcg aatcaatctg tttactgtgg 11281 gtcgcgttac tgaaggttta gcgcgtttga ttgatgaaaa tggtgaggaa gctaaaaaac 11341 gtggagtagt aattgctttt gactcaagat atcattcaag agaatttgca gaacacgctg 11401 ctagagtact tggtgcacat ggtattcatg tttacttatt tgatgaccta agaccaactc 11461 cagaattatc atatgcagtt cgtcacttaa atacttttgc aggaataaat atcactgctt 11521 cgcataatgc taagcaatat aatggataca aggtttacgg tgaagatggt gcacaaatgg 11581 ccccagaaaa tgccgatcgt ttatttgctt atgcacaaaa agttactgat atttttggtg 11641 ttgaagttgc ttcagttaaa gaattacgcg caaataatac tttgcaatta attggtgaag 11701 atgttgatga agcttattta aatgaattaa agcaagttac agttgataaa gaaatggtaa 11761 aagctaatgc tgacaagctt aaaatcattt atactccact tcatggtaca ggtaaaatgc 11821 tttatgatcg tgcatttaga caaggcggtt ttgacaatgt aattcctgtt ccaagtcaat 11881 caattatcga tccagaattt ccaacaacta ttaagcctaa cccagaatat cgtgatgtat 11941 ttgaaccagg ctttaagctg gctgataaag tagatgccaa tgtaattatt gcaactgatc 12001 ctgatgcaga tagaatgggt gcagctgtga gaaaatccga tggtgatttc caagttctaa 12061 ctggtaatca aattgctact ttaatggcat attatttgtt agctcacctt aaagagagtg 12121 gcaagttaac tgatgattat gaaattgtta cttcagtagt ttcaagtgca ttgccattta 12181 agattgccga agattttggt attaagacta aacatgtttt aactggtttt aagtatatcg 12241 gtgaagaagt tgaccgtatg aataaagctg gagatgctaa gttcttaatg ggctttgaag 12301 agagttatgg ttacttattt aagccttttg cacgtgataa agatgctatg caaggtgcat 12361 taatgtttgc tgaagttgca agctactatg cttctcgtgg tatgaccgta tttgatggct 12421 tacaagaaat ttggaagaaa tatggtgtcg cttacgaaat tactcgtgcc attgaaatgc 12481 ctggtattgg tggtcagaag aagatggctg aattgatgag caagcttcgt aatgaacatc 12541 ttactgaaat tggcggtagc aaagtagtta aaattcaaga ctttttaaaa caagaaacaa 12601 ttgaaaatgg tgaaaagaca ccacttgaag gtttcccaga atcaaatgtt ttgaaatact 12661 tcttagatga tgaaacttgg gttgctcttc gtccatcagg cactgaacca gttattaaag 12721 cttatgttgg tgtaaataaa gaaaatattg aaaaagcaga aaaggctgca gaagattacc 12781 aaactgcctt ggcaaattta cttaaataat caagcatatt gtgtgcgaaa acacgttcgt 12841 ggtagtaaaa tataaatact aattagagaa gttggacaaa aagtccaact tttttcgtga 12901 ggagctttgc tatgataaaa cgacaaaaag atcgtaagtt tgaattagta tcaaaattta 12961 agccggcagg ggaccagcag caagctatca ataagttgac agcgggtttt gaaaagggat 13021 ataaggaaca aattttagag ggtgccactg gtactgggaa gacttttacc atggctaaca 13081 ttattgctaa gcttaacaag ccaactttgg tcattacaca taataaaaca ttggttggtc 13141 agctttatgg cgaatttaag ggatttttcc ctaataatgc ggttgaatat tttgtctcat 13201 actatgatta ctatcaacca gaagcgtatg ttccacaatc cgatacatac attgaaaaag 13261 attctgcaat taatgatgaa attgatcaat tgcggcatgc tactacttca gctttaatgg 13321 agagaaatga tgtaatagtt gttgcttcgg tttcatgtat ttatgggttg ggtgatccta 13381 aagaatatgc tcgtagtgta ttaatgattc atgaaggaca agaatatgaa cgtaatacgt 13441 tattacgtga tttagtaaac ttgcaatatg atcgaaatga tattgatttt caacgaggac 13501 gttttcgggt ccgtggtgac gttgtagaaa ttttcccagc aggaaattct aaccatgcct 13561 atcgtgttga atttttcggt gatgaaattg accgaattgt tgagatcgat tctttaactg 13621 gggaagtaat tggtgagcgt gagagtatat cgctgtttcc ggctacgcac ttcatgacta 13681 atgatgaaca attaagacga gctcttaagg cgatttctaa agaaatgaaa gtgcaagtta 13741 aaaagttcga aggcgaaggt aaattgcttg aagccgaaag aattaaacaa agaactacct 13801 atgatatgga aatgatggga gaagttggtt ataccaacgg aattgaaaat tactcaaggc 13861 atatggaagg tagaaaagta ggagagccac catatacttt gcttgatttc ttcccagatg 13921 attttttgat tttaattgat gaatctcatg caaccatgcc agaaattaga gcgatgtaca 13981 atggagatcg taatcgtaaa aagaccttaa ttgattatgg ctttcgttta ccatcggcac 14041 ttgataaccg tccactaaag ttggcagaat ttgaaaaaca tgttaaccaa attttatacg 14101 tttctgctac tcctggagat tatgaacttg agaggacaga tcacaaggta gagcagatta 14161 ttcgtccaac gggattattg gatcctaaga ttgaagtaag gccaatcgaa ggacaaattg 14221 atgatttagt cggagaaata aataagcgga tagatcgtaa tgaacgtgtt tttgttacta 14281 ctttaactaa aaagatggcc gaagatctga cagattattt aaaagatctg ggtattaaag 14341 ttcgttattt acattcagat attaaaacgc ttgaaagaat gcagatctta cgtgatttac 14401 gtttgggtaa atttgatgta ctgattggga ttaacttact tcgtgaaggt attgacgtgc 14461 ctgaggtatc gctagtggcg attttagatg cagataaaga aggttttctt agagcatacc 14521 ggccattagt tcaaacaatg gggcgtgcag cacgtaatgc aaatggagaa gtaattatgt 14581 atgctgatac gattaccgat tcgatgaaag cagctatcga ggcaacccag agaagacgca 14641 agttacagga agaatttaat aaagaacacg ggattgttcc taagacgatt attaaacctg 14701 ttcatgatgt tatttcaatt actaagccat ctgaagactc taagaaagaa aaaacagata 14761 gttttgcaga tttgaatttt gatgaattaa cagctaaaca aaagaagacg atgattaaga 14821 atttgcaaga acagatgaaa gaggccgcta agaaacttga ctttgaagaa gcagcaaact 14881 tgcgggatgc aataatggaa ttgcagtcat catctagaag accaaaaaca agaaaaggga 14941 aggcattaaa tggtaaacga taa //