LOCUS CP000033 15057 bp DNA linear BCT 30-JAN-2014 DEFINITION Lactobacillus acidophilus NCFM, complete genome. ACCESSION CP000033 VERSION CP000033.3 DBLINK BioProject: PRJNA82 BioSample: SAMN02603047 KEYWORDS . SOURCE Lactobacillus acidophilus NCFM ORGANISM Lactobacillus acidophilus NCFM Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 15057) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (11), 3906-3912 (2005) PUBMED 15671160 REFERENCE 2 (bases 1 to 15057) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (15-OCT-2004) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REFERENCE 3 (bases 1 to 15057) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (02-FEB-2007) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REMARK Sequence update by submitter REFERENCE 4 (bases 1 to 15057) AUTHORS Altermann,E., Russell,W.M., Azcarate-Peril,M.A., Barrangou,R., Buck,B.L., McAuliffe,O., Souther,N., Dobson,A., Duong,T., Callanan,M., Lick,S., Hamrick,A., Cano,R. and Klaenhammer,T.R. TITLE Direct Submission JOURNAL Submitted (01-NOV-2007) Department of Food Science, North Carolina State University, Raleigh, NC 27695-7624, USA REMARK Sequence update by submitter COMMENT On Nov 1, 2007 this sequence version replaced CP000033.2. FEATURES Location/Qualifiers source 1..15057 /organism="Lactobacillus acidophilus NCFM" /mol_type="genomic DNA" /strain="NCFM" /db_xref="taxon:272621" gene complement(1..858) /locus_tag="LBA1864" CDS complement(1..858) /locus_tag="LBA1864" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q8DT26|3.A.1.1.27" /protein_id="AAV43664.1" /translation="MKSYSNQRRLSLIFRYILLTVLAILWILPIVWIVLASFSYNDTGF VSTFWPEQFTLQNYIGIFTNSQYPFVNWIINTLIVSLLSMIISTFLTISVAYVLSRLRF KFRKPFLQIALVLGMFPGFMSMIALYYILKGLNMLNLFGLLLVYVGGAGLGFYVAKGFF DTIPRSIDEAAEIDGATKWQVFLHIGLPLSKPMIVYTALTAFIAPWTDFIFSGIILSTS GNAKTYTIAYGLYNMVHTAKGNATAYFAQFVAGCVIIAIPITILFVFMQKFYVNGITAG ADKG" gene complement(861..2234) /locus_tag="LBA1865" CDS complement(861..2219) /locus_tag="LBA1865" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q8DT27|3.A.1.1.27" /protein_id="AAV43665.1" /translation="MFLKKKHVAPKATYREVWSKGDLATKLSFFIMGSNALANKQWVKG LAFLLSEIIFIVWFVLSGIPTLNTLATLGTNKTKKVVYDAAQGVYVTKQPSNSVLILLF GVLAVILCIAIIYLYIVNLRSTRHNYILKRDGGHIPTNVEELKSLLDTRLHATLMVIPL LGILFFTILPTIFMISMAFTNYDRQHPIAFSWTGFQAFGNVLSGDLAGTFFPVLGWTLI WAVAATATTFFFGVLLALLIESKGIKHKGFWRTVFVIVWAVPQFVSLLMMAQFLDYQGA LNNILMNLHWISSPIHFIDNQASPLVARITVIIVNMWIGIPVSMLVSTAIIQNLPQDQI EAAKIDGANAAQIFRSITFPQILFVMAPSLIQQFIGNINNFNVIFLLTGGAPMNSHYNG AGSTDLLVTWLYNLTFGQEQRYNASAVLGILIFIISAVVSLIAYRHTNAYKEG" regulatory complement(2227..2234) /regulatory_class="ribosome_binding_site" /locus_tag="LBA1865" gene complement(2290..3530) /locus_tag="LBA1866" CDS complement(2290..3516) /locus_tag="LBA1866" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q8DT28|3.A.1.1.27" /protein_id="AAV43666.1" /translation="MKFWKKMALGSTAVLAAMSLAACSNGSSNSSSSSNTSNKKANLTL WVDTEQVPYYKQIAKDFTKKNKNIKVRVVQSPNGSANAKTDVGKDPSKAADVFEVPNDQ LGQMAEAGYINPLSPSASKDIKANYIDVASKGVTWKGKVYAFSYAQQAQTIYYNKSKLS ANDVKDWKTLTSKGVVATDFTNAYVMWPVMFSAGTKLYGNNGEDLKGSTFNSQDGINAL KWYAAQKKNKGVMQTSNALNQLKKGNAQAILDGPWNAANIKKILGKNFAVAKYPKIDVG GKNVQMEAFLGIEGFAVNSNTKNAKAASDLAAYITNKKSQLIAHKEAGQIPVLKAAVNS SAVKSDPVAEAVIEMAKPGNSVLQPKLPQMAAFWNGSAPLISGTYDGKIKPSQYKAQLA KLAKTVEKK" regulatory complement(3524..3530) /regulatory_class="ribosome_binding_site" /locus_tag="LBA1866" gene complement(3603..4709) /gene="msmK" /locus_tag="LBA1867" CDS complement(3603..4709) /gene="msmK" /locus_tag="LBA1867" /note="MsmK" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q7WWQ6|3.A.1.1.20" /protein_id="AAV43667.1" /translation="MVEVDLNHIYKKYAGNDRYSVNDFNLHIKDKEFIVFVGPSGCGKS TTLRMVAGLEDISEGTLEIDHKVMNDVAPKDRHIAMVFQNYALYPHMTIYDNMAFGLKL RHTPKDVIDKKVKEAAKMLGLEDYLDKKPGALSGGQRQRVALGRAIVRAAPIFLMDEPL SNLDAKLRVVMRTEIAKLHQELGTTTIYVTHDQTEAMTLADRVVVMSVGKVEQIGSPLE VYNKPVNMFVAGFIGSPQMNFFNVHYKNGRISDGKGLNIGIPEGKAKLLEEKGYNDKDL VFGIRPEDIHSEEAFMETWPDSVVESKVVVSELLGATIQLHQEVDGTEFTAIVNSRDFH KPGDMVRMGFDVNKAHFFDKDSTKAIVN" gene 4758..6140 /locus_tag="LBA1868" CDS 4758..6140 /locus_tag="LBA1868" /codon_start=1 /transl_table=11 /product="STP|HTH_12" /protein_id="AAV43668.1" /translation="MSKLNKKQRLKIYNDWRNGNESLSVIASEIKLNRSTLQYMVNLID RHGIEIYDKSKELFTKEFKEKAIVRSLTGNNSINQLSLDLGLRSNGILYNWIREYKKNG YNVVIKKKGRHSVHESEEAIPNIAQRFREADPATQRRKLEIAYRQCLRKKTKRLGSETS QEIAQAVTELRQEFKVSLDYIFTVLAQNKDLPLIARSTYYNIIKPKDKPKRKKPGFLSR MKEIFDYHQRRYGYRRVAMQLRKEGYAVTDRAVRYWMHKLKLKGRRRNKRKYSSYKGTI GKIAPNLIHRGFFAIRPNMKWYTDITEFHLNGQKLYLSPILDGCGGDIVSYSISRHPDM NLVMSMLNKAFAKHKALNACIFHTDQGCQYQSRVYQRALKLHGITQSMSRKGNSMDDGL MENFFGLLKTEMFYDQEYKYHNLEELTQAIEEYIKYYNNERIKSRLKGLTPIEYRDQAL VS" gene complement(6198..6863) /gene="pgmB" /locus_tag="LBA1869" CDS complement(6198..6863) /gene="pgmB" /locus_tag="LBA1869" /EC_number="5.4.2.6" /note="COG0637 Predicted phosphatase-phosphohexomutase" /codon_start=1 /transl_table=11 /product="beta-phosphoglucomutase" /protein_id="AAV43669.1" /translation="MLKGLIFDLDGVLTDSARFHLTAWNNLAKELGITLTNEQLDSLRG ISRMDSLNLILKYGGQEDKYTEAEKEKFAAEKNAKFVEQVETMTPKDILPGIPELLSDA KKQNLKMVIASASKNAPKILTRLGIMDEFDGIVDPATLHHGKPDPEIYIKAQELVGLKA NEVISFEDAQAGVEAIKAAHQFAVGIGNKKLLKEADYIVPTTADLKLSEIEKVFEEKE" gene complement(6848..9130) /locus_tag="LBA1870" CDS complement(6848..9118) /locus_tag="LBA1870" /EC_number="2.4.1.8" /codon_start=1 /transl_table=11 /product="GH65" /protein_id="AAV43670.1" /translation="MKRIFEIDPWKVITHKFDPKDKRLQESMTAIGNDYMGMRGNFEEG YSGDSLQGTYLAGVWFPDKTVVGWWKNGYPKYFGKTPNAPSFIGIGINVNGEKVDLAKV KFSDFELSLDMHQGLLSRSFIYEGKDVKVKLEFERFLHIVQKEAALIKVKATVLEGHAK IDFDSTLDGTVVNEDSNYGDRFWIPLGEDKDEKTIQVKTKKNPYDVPQFTVLLKEALRN NGVAVNGEVTTEDAKLSERFSVELDEGQSYELEKDVIVVTSRDVEEKDQAAVANNLMSK LQTKSFEDNLADHTEAWKKRWETSDVEISGDDAAQQGIRFNICQLFMTYYGEDKRLNVG PKGFTGEKYGGATYWDTEAFIVPMYLAVTKPSVTRALLQYRHDQLPGAYHNAKEQGLPG ALFPMVTFNGIECHNEWEITFEEIHRNADIPHAIAMYTDYTGDDSYVKNEGMDVLVGTA RFWAARVHWSKMRNKYVMHGVTGPNEYENNVNNNWFTNTMARWLLKYTLERLPLATKEA QERVRVTDEEKAKWQDIVDNMYLPEDEDLGIFLQQDDFLDKDIRPVTEIEDQRPINQHW SWDKILRSPFIKQADVLQGIYFFDDQYTMDQKEKNFDFYEPLTVHESSLSPCIYSIMAA ELGKKEKAVELYQRTARLDLDNYNNDTVDGLHITSMSGSWLAIVQGFAGMRYDHDQLKF NPFVPDGWDHYSFKINYRGRLIEVYVDHDECKITLLSGDDLEVMVHDNKLDLKEGKTKC LKA" regulatory complement(9125..9130) /regulatory_class="ribosome_binding_site" /locus_tag="LBA1870" gene complement(9289..11010) /locus_tag="LBA1871" CDS complement(9289..11010) /locus_tag="LBA1871" /EC_number="3.2.1.135" /note="COG0366 Glycosidases" /codon_start=1 /transl_table=11 /product="CBM34|GH13|GH13_20" /protein_id="AAV43671.1" /translation="MQLAALRHRTESEDSFVVDPKHVRVRFHTAKNDVEKVIVHYCDNY LPLKFAETTEMEKIGEGQVEDYWGITLDAPYHRLKYTFEVIGKDGTSVVYGDRAISDDI KDAINEDGSYFKIPYCHEIDMVKTPDWVKNTVWYQIFPERYANGDKSNDPKNIKPWNPT DHPGREDYYGGDLQGVLDHLDYLQKLGVNGLYFCPIFKASSNHKYDTIDYLQVDPEFGD KDLFAKVVNEAHARGMKIMLDAVFNHLGDQSMQWQDVVQNGSKSRFADWFHINEYPVEP YRNPLKGEKNPQYDTFAFEEHMPKLNTANPEVQDFLLEIATYWVKYFDIDAWRLDVANE VDHHFWKKFHKAVTDIKPDFYIVGEVWHSARPWLNGDEFTGVMNYPYTLQIEDHFFKHK LTADQMTTRLTDQLMKYRDSTNEAMMNMLDSHDTARILTVAKGDQDLALQALTFEFMQK GSPCIYYGTEMGMAGDNDPDCRKPMDWSKEDGPVWQRVHKLIKFRLAHDKTLSEGKIKL SVTENRLIEVIREGKESIHAYFNTTKNDVKLDGKAELSQDFEKGILAPKGFVIMVD" gene complement(11014..12683) /locus_tag="LBA1872" CDS complement(11014..12669) /locus_tag="LBA1872" /EC_number="3.2.1.10" /note="COG0366 Glycosidases" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q05839|8.A.9.1.1" /protein_id="AAV43672.1" /translation="MSHWYDHAIIYQIYPKSFQDSNDDGIGDLNGIRKRIPYLQNLGVN AVWLNPVFVSPQVDNGYDVSNYFAIDSHMGTMEDMENLIKDLHKAGIHIIMDFVLNHTS DQHPWFQDAIKNPDSLYRDYYIFAGHDNKQPNNWGSFFGGSVWEPDPAGTGQSYFHLFD KRMPDLNWKNPEVRHAMLEIAEFWLKKGIDGLRLDAFIHIGKADLRQNYPAMDDKPVIA EPFFANLPQVQEWMRPFCEQIKEDYPDALLLGEAASASVNLAVDYTNKRNHLMDCVITF RYFTEDDSKIDKSYSAQYQPKELDLTAFKQNQVVWQQTLADISQPTLYWNNHDMARLAT RIAKTSTQAKSLAMLMYLQRGIPIIYYGEELGLKNLHFTSVDQFEDQTVAPWIKEAQKA GISRDAAFAMVSDTHKLPARGPMPWNDTENNGFTSAKPWLNGISQDDVTVANEVNSDNS MFTFYKNMLNLKKEKLFQDGTYYMISTGKDSYVYQRDLGNESAIVAVSLSNKKISIDLP EEYIKELLKAGEYQLTNGKLTLMPYAGVVLKKEN" regulatory complement(12677..12683) /regulatory_class="ribosome_binding_site" /locus_tag="LBA1872" gene complement(12781..13970) /gene="ackA" /locus_tag="LBA1873" CDS complement(12781..13956) /gene="ackA" /locus_tag="LBA1873" /EC_number="2.7.2.1" /note="COG0282 Acetate kinase" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="AAV43673.1" /translation="MKKVLAINSGSSSFKYKLFTFPNEKVVASGMADRVGMANAVFKIK LNSKEYIKNTPIPNQEAAVSLLIESLKKFNVVKDLKELSGVGHRVVNGGEVFKHSVVIN QANLKQLIKLGNLAPLHNIPETVGIEAFMQIIPDIPQIAVFDTSYHQSLSEINYLYSIP YRYYEDYAVRKYGAHGISVEYVAPRAAKMMGKNLNISKLIVCHLGSGSSVTAVKNGKSY DTSMGFSPLTGVTMGTRSGDFDPSALRYIMDKTGMSIDEGIDMLNHESGLLGISGVSSD MRDLIESKQKRAELARRIYINRVVRYVGAYAAEMDGVDGIIFTAGVGEHDSGIRAGVMS SLRYLGLKPDYKANRTDGEKFISMPNSKVKALVVPTNEELMIAREVVRLTR" regulatory complement(13965..13970) /regulatory_class="ribosome_binding_site" /gene="ackA" /locus_tag="LBA1873" gene complement(14097..15057) /locus_tag="LBA1874" CDS complement(14097..15047) /locus_tag="LBA1874" /note="LacI; COG1609 transcriptional regulators" /codon_start=1 /transl_table=11 /product="DBD-Pfam|LacI,DBD-SUPERFAMILY|0036955" /protein_id="AAV43674.1" /translation="MTTLSDVAKEANVSKMTVSRVINHPEQVTPELRAMVEKAMEKLNY HPNSIAQALVNNRSNVVKFVTLEDIDTTEPYYTNLLFGFARGLNAKQYALQLVVDPTRI EKGRADGYLITGARNEDYDMFDKLDKPFVLFGENHRGYDFVDTDNQTAEKMATQYALDR LYKHIIFIGIDIKEPFEYSREAGYINTLQQHRLIPQIYRVSNHSHAAQKVIHEHFKEFK KDTCFICASDRIAVGVVRQLQDERARIPEDFGVIGFDGVFLDQVSNPKLTTIKQPIFEM GKMLAKMLLQKIDQSGSPQGELMVKPQLIRRETTR" regulatory complement(15051..15057) /regulatory_class="ribosome_binding_site" /locus_tag="LBA1874" ORIGIN 1 ttaaccttta tcagcaccag cagtaatacc attaacatag aacttctgca tgaagacaaa 61 caagatagta atagggatag caatgattac acatcctgca acgaattgtg caaagtatgc 121 agttgcatta cccttagccg tgtgaaccat gttgtaaagt ccgtaggcaa tagtataagt 181 cttcgcattt cctgaagttg aaagaatgat acctgagaaa atgaagtctg tccaaggtgc 241 aatgaaagca gttaaagcag tataaacgat cattggcttt gaaagtggca atccaatatg 301 aagaaatact tgccacttag tagcaccatc aatttcagca gcttcatcaa ttgatctagg 361 aattgtatca aagaatcctt tagcaacgta gaagccaagt ccggcaccac caacgtaaac 421 caaaagtaaa ccaaagaggt ttaacatatt caaacctttt aagatgtagt acaaggcaat 481 cattgacatg aaacctggga acatccccaa aactaaagca atttgaagaa atggctttct 541 aaacttaaaa cgaagtcgtg ataaaacata ggcaactgaa attgttaaga atgttgagat 601 aatcattgaa agaagtgaaa caatcaatgt attaataatc cagttaacaa atggatactg 661 tgaattagta aaaataccaa tatagttttg caaagtaaat tgttctggcc agaaggtcga 721 aacaaatcca gtatcattgt atgaaaaact tgccaagacg atccagacaa tcggtaaaat 781 ccaaagaata gctaatacag ttaaaagaat ataccgaaag attaatgaga gccgtctttg 841 attagaatat gacttcatgt ctagccctcc ttataagcgt tagtgtgtct atatgctatc 901 aacgatacaa ccgcactaat tataaagatt aagataccaa gtacggctga agcgttatat 961 cgctgctctt gcccgaacgt taagttatac aaccacgtta ccagtaagtc agtcgatccg 1021 gcgccgttat agtgactgtt catcggcgca ccacctgtca gcaagaagat aacattgaag 1081 ttgttaatgt taccaataaa ttgttggata agtgaaggtg ccataacaaa taagatttgt 1141 gggaaagtaa ttgatctgaa aatttgtgca gcattagcac catcaatctt ggcagcttca 1201 atttgatctt gtggcaagtt ttgaataata gctgtagata ccagcattga aactggaata 1261 ccgatccaca tgttaacaat aataactgta attctggcta ccaatggtga agcctggtta 1321 tcaataaagt ggataggaga gctaatccag tgtaagttca tcaagatatt gtttaaagca 1381 ccttgatagt ccaagaactg agccatcatt aaaagtgaaa cgaattgagg aacagcccaa 1441 acaattacaa agactgttct ccaaaagccc ttatgtttaa tacccttgga ttcaatcaat 1501 aaagcaagta acacaccaaa gaagaaagta gtagcagtag ctgctacagc ccaaatcaat 1561 gtccagccca atactgggaa gaaagtaccc gctaagtcac cactaagaac attaccaaat 1621 gcttgaaatc cagtccaaga gaaggcaatt gggtgttgac ggtcatagtt agtaaatgcc 1681 attgaaatca taaagattgt tggcaagatg gtaaagaaca aaatacctaa taatggtata 1741 accattaaag ttgcgtgtaa acgcgtgtca agtaagctct taagttcttc aacattggtc 1801 ggaatgtgac caccatcacg ttttaatatg taattatgtc ttgttgagcg caagttaaca 1861 atgtatagat aaataattgc tatacataaa attactgcca gcaccccaaa tagcaaaatt 1921 aaaactgagt ttgacggttg cttagtaaca taaacacctt gtgcagcatc ataaacaact 1981 tttttggtct tattagtacc taatgtagct aaagtattta aagttggaat accgctaaga 2041 acaaaccaaa caatgaaaat aatttctgaa agtaaaaatg caagaccttt tacccattgt 2101 ttgttagcta aggcattact acccattatg aaaaatgata acttggtagc aagatcacct 2161 tttgaccata cttcacggta tgtcgcttta ggagctacat gctttttctt tagaaacata 2221 acttctcccc ttcttaggca aaaaggttgg acaattttta gcccaacctt tgcttatgct 2281 tttagttgac tatttctttt caacagtctt tgcgagttta gcaagttgtg ccttgtattg 2341 acttggctta atcttaccat cgtaagtacc actgataagt ggagctgaac cattccagaa 2401 tgcagccatt tgtggaagct taggttgcaa tactgagtta cctggcttag ccatttcaat 2461 tacagcttca gcaactggat cactcttaac tgcacttgag ttaactgcag cctttaatac 2521 aggaatttga cctgcttctt tgtgagcaat caattgtgac ttcttattag tgatgtaagc 2581 agctaagtct gaagcagctt tagcattctt agtgtttgag ttaactgcga agccttcaat 2641 accaaggaat gcttccattt gtacattctt accgccaaca tcaatcttag gatacttagc 2701 aactgcaaag ttcttaccta aaatcttctt aatattagct gcgttccatg gaccatcaag 2761 gattgcttga gcattaccct tcttcaattg attcaaagca tttgaagttt gcattacgcc 2821 tttattcttc ttttgagctg cgtaccactt caaagcatta ataccgtctt gtgaattaaa 2881 tgttgaaccc ttaaggtctt caccattgtt accataaagc ttcgtacctg ctgagaacat 2941 tactggccac attacatatg cgttagtgaa gtcagtagct acaacacctt tagaagttaa 3001 agtcttccaa tccttaacgt catttgctga aagcttagac ttgttgtagt aaatagtttg 3061 agcttgttgt gcgtatgaaa atgcgtaaac cttgcccttc caagttacac cctttgatgc 3121 aacatcaatg tagttagcct tgatgtcctt agatgcagat ggtgaaagtg ggttaatgta 3181 gcctgcttct gccatttgac ctaattggtc gttaggtact tcaaatacat cagctgcctt 3241 tgatgggtcc ttaccaacat ctgtcttagc gttagctgaa ccgtttggac tttgtacaac 3301 acgaacctta atgttcttgt tcttcttagt aaagtcctta gcaatttgtt tgtagtaagg 3361 tacttgttca gtatctaccc aaagtgtcaa gttagccttc ttatttgaag tgttacttga 3421 acttgatgaa tttgatgagc catttgaaca agctgcaagt gacatagcag ctaaaacagc 3481 agtactacct aaagccattt tcttccaaaa cttcatgact ttttcctcct aaaaaatcaa 3541 aacaataaac aattcttaac aacagtagcc tttgctacct atggttgtaa gctttaataa 3601 aattagttaa cgatagcttt tgtactatcc ttatcgaaga agtgagcctt attaacatcg 3661 aagcccatcc tgaccatatc acctggttta tggaaatcac gtgaatttac gattgcagta 3721 aattcagtgc catctacttc ttggtgaagt tgaatagttg cacctaaaag ttctgaaaca 3781 acaacttttg attcaactac tgaatctggc caagtttcca taaatgcttc ttctgagtga 3841 atatcttctg gacgaatacc gaagactaag tccttatcgt tgtatccttt ttcttcaagt 3901 aattttgctt taccttcagg aataccaata ttcaaccctt tgccatcact aattcgaccg 3961 ttcttatagt gaacattgaa gaagttcatt tgaggagaac caatgaatcc agcaacaaac 4021 atatttactg gcttgttgta aacctcaagt ggtgacccga tttgctcaac tttaccaaca 4081 gacataacaa caactctgtc agccaaagtc atcgcttcag tctgatcgtg ggtaacataa 4141 atagttgtag ttcccaattc ttggtgaagc ttagcaattt ctgtacgcat caccacacga 4201 agcttagcat caagatttga taatggttca tccattaaga agataggtgc ggcacgaacg 4261 atcgcacgtc ctaatgcaac acgctgtctt tgaccaccgg ataaagcacc tggcttttta 4321 tctagataat cttctagacc taacatctta gctgcttctt taaccttctt gtcgataaca 4381 tccttaggtg tgtgacgaag cttaagacca aatgccatgt tgtcataaat ggtcatatgt 4441 ggatacaaag catagttctg gaaaaccatc gcaatgtgac ggtcttttgg agcaacatcg 4501 ttcattactt tatgatcgat ttccaaagtt ccttcactga tatcttccaa accggcaacc 4561 attcttaatg tagttgactt accacaacct gatggaccaa cgaaaacgat aaattccttg 4621 tctttaatgt gtaagttaaa gtcatttaca gaataccgat cgttacctgc atatttcttg 4681 taaatatggt ttaaatcaac ctcaaccatt gtttctgaag tgggccgtaa aagttagaca 4741 cttttacggc ttttactatg tccaaattaa acaaaaaaca aagacttaaa atttataatg 4801 attggagaaa tggaaatgaa tccttatctg taatcgcttc tgaaataaaa ttaaatcgtt 4861 ctaccctaca atatatggtt aatttaatag atcgtcatgg gatcgaaatc tatgataaat 4921 ctaaggaatt gtttaccaaa gaatttaagg aaaaagccat tgttagatca ttaactggta 4981 ataattcaat taatcagttg tctttagatc tgggactaag aagcaacggt atcttgtata 5041 attggattcg cgaatataag aaaaatgggt ataatgtcgt tatcaagaag aaaggacggc 5101 attccgttca tgagtcagaa gaagcaatcc caaacatcgc gcaaagattt agagaagcag 5161 atccagcaac tcaaagaaga aaacttgaaa ttgcgtatcg tcaatgccta cgtaaaaaaa 5221 ctaaacgcct tggatcagaa acatcacaag aaatagctca ggcagtcact gaactaaggc 5281 aagaattcaa ggttagcttg gactatatat ttacagtctt ggctcaaaat aaagatctgc 5341 ctttaatagc tcgcagtact tactacaaca ttatcaagcc taaagataag cctaagagaa 5401 agaaaccagg tttcttatcc agaatgaaag aaatcttcga ttatcatcaa agacgttatg 5461 gctatcgtcg tgtagctatg caattgcgaa aagaaggcta tgccgttaca gatcgagcag 5521 ttcgatactg gatgcacaaa cttaagctca aaggtcgaag acgcaacaag cgtaagtatt 5581 ccagttataa aggtacgatt ggtaagatag ctccaaatct gattcatcga ggcttctttg 5641 ccatacgacc aaatatgaag tggtatacag acatcactga atttcactta aatggtcaga 5701 aactttactt atcgccaatt cttgacggct gtggtggtga tatagtttct tattcaatct 5761 cacgtcatcc ggatatgaat ttagttatgt ccatgctcaa taaggctttt gccaagcata 5821 aggcacttaa tgcctgtatt tttcacacag atcagggctg tcaatatcag agcagagttt 5881 atcagcgagc cttaaagctt catggcatca cgcaaagcat gtctcgtaaa ggtaattcca 5941 tggatgatgg tctaatggaa aacttctttg gcctgctcaa aacagaaatg ttctatgatc 6001 aggagtacaa gtatcacaat cttgaagaat taacacaagc aatcgaagaa tatatcaaat 6061 actataacaa cgaaaggata aagagcagac taaaaggctt aaccccgatt gaatatcgag 6121 atcaagcctt agtcagctag aacaaatatt tgtctaattt ttacgtctca gtacattccc 6181 ctactctctt ttaattttta ttctttctct tcaaaaactt tttcaatttc actaagctta 6241 agatcagcag tggttggaac gatgtaatca gcttctttca aaagcttttt attacctatt 6301 ccaactgcaa attgatgagc agccttaatt gcttcaacac cagcttgggc atcttcaaag 6361 ctaattactt catttgcctt caatccaaca agttcttgcg ctttgatata aatttctgga 6421 tctggcttac catgatgaag agtggcagga tcaacaatcc catcaaattc atccataatt 6481 cctagtctag ttaaaatctt aggtgcattc tttgaagcag aagcaattac catctttaag 6541 ttttgcttct tagcatcact aagtaattct ggaatgccag gtaggatatc ctttggtgtc 6601 attgtttcaa cttgctcaac aaacttagca ttcttttctg cagcaaattt ttctttttct 6661 gcttcagtat acttatcttc ttgaccgcca tacttcaaga tcaaattaag cgaatccatt 6721 cttgaaatac cacgtaaact atcaagttgt tcgtttgtta aagtaatgcc taattcctta 6781 gccaaattat tccaagctgt aaggtggaaa cgtgctgagt cggttaagac accatctaaa 6841 tcaaaaatta agcctttaag catttagttt taccttcctt caaatccaat ttattgtcat 6901 gtaccatgac ttcaagatca tcaccagaaa gtaaagtaat cttgcattca tcatgatcta 6961 cataaacttc aatcaaacga ccacgataat taatcttaaa gctgtagtga tcccaaccat 7021 caggaacaaa tgggttgaac ttcaattgat catgatcgta acgcatccct gcgaaacctt 7081 gaacaatcgc aagccatgaa ccactcattg aagtaatgtg taaaccatct actgtgtcgt 7141 tattatagtt atcaaggtca agacgtgcag ttctttggta aagttcaact gccttttctt 7201 tcttgccaag ttctgcagcc ataattgagt aaatacatgg tgaaagtgaa ctttcgtgaa 7261 ctgttaatgg ttcatagaaa tcgaagttct tttccttttg atccatagtg tattgatcat 7321 caaagaagta aataccttgt aaaacatcgg cttgcttaat aaatggtgaa cgtaaaatct 7381 tgtcccatga ccagtgttga ttaattggac gttgatcttc aatctcagta acaggacgaa 7441 tatctttatc taagaaatca tcttgttgca agaaaatgcc aagatcttca tcttctggta 7501 agtacatgtt atccacaata tcttgccatt tagctttttc ttcgtcagta acacgaactc 7561 tttcttgagc ttccttagta gcaagtggca aacgttccaa agtatatttg agaagccatc 7621 tagccattgt gttagtaaac cagttgttgt ttacgttatt ttcatattca ttaggacctg 7681 ttacaccgtg cattacgtat ttgttacgca tctttgacca gtgaactcta gctgcccaga 7741 atcttgctgt accgactaaa acgtccatac cttcattctt aacgtaactg tcatcgccag 7801 tgtaatcagt gtacatggct attgcgtggg gaatatctgc atttctgtga atttcttcaa 7861 atgtgatttc ccattcgttg tgacattcaa taccattgaa ggtaaccatt gggaataatg 7921 cacctggaag gccttgttct ttagcattat ggtaagcacc tggcaattga tcgtgacgat 7981 attgaagaag tgctcttgta acacttggtt tagttactgc taaatacatt ggaacgataa 8041 aggcttcggt atcccaataa gtggcaccac cgtatttttc accagtaaag cctttaggac 8101 ctacattcaa gcgcttgtct tcaccgtaat atgtcataaa taattgacaa atattgaagc 8161 gaataccttg ttgagctgca tcgtcgccgc tgatttctac atcacttgtt tcccaacgct 8221 tcttccaagc ttctgtatga tctgctaagt tatcttcaaa actcttggtt tgaagtttac 8281 tcatcaagtt gttagcaacg gctgcttgat ctttttcttc aacatcacga ctagttacaa 8341 caatgacatc tttttcaagt tcatagcttt gaccttcgtc taattctact gagaatcttt 8401 cactcaattt tgcatcttca gtagtaactt ctccatttac tgctacgcca ttattacgta 8461 atgcttcttt caacaatact gtaaattgtg gtacgtcata tggatttttc ttagtcttta 8521 cttgaatagt tttttcatct ttatcttcac caagtggaat ccagaagcga tcgccataat 8581 tactgtcttc attaacaaca gtgccgtcta aagttgagtc aaaatcaatc tttgcatggc 8641 cttcaagtac agttgcttta actttaatta gagcagcttc tttttgaaca atgtgaagaa 8701 agcgttcaaa ttcaagctta actttgacat ctttaccttc atagataaaa cttctcgaaa 8761 gaagaccttg atgcatgtct agtgataatt caaagtcgct aaatttaact ttagctaaat 8821 cgaccttttc accatttaca ttgattccaa ttccaataaa acttggagca tttggtgttt 8881 taccaaaata ttttggatat ccattcttcc accaaccaac aaccgtttta tctgggaacc 8941 aaactcctgc taagtatgta ccttggaggc tatcacctga ataaccttct tcaaagtttc 9001 ctctcattcc catgtaatcg ttaccgattg cagtcatact ttcctgcaat ctcttatctt 9061 ttggatcaaa tttatgagta atgactttcc aaggatcaat ttcaaaaatt cgtttcatat 9121 aatatctccc gcaatatttg aagtgcttat ttgtttacgc tttcattatc atgtaattga 9181 aagcggttta caacatcaaa agccatgtta ccggtatcag aattaattaa taaaaaaaga 9241 aggtagaact taacctacct tctttttctt gcttattaaa agtaactttt aatcaaccat 9301 gattacaaag ccttttggag cgagtattcc tttttcaaaa tcttgactta attcagcttt 9361 accatcaagt tttacatcat ttttagttgt attaaagtaa gcatgaatac tttctttgcc 9421 ctctctaata acttcaatta gcctattttc tgttacgctt aacttgattt taccttcact 9481 gagcgtttta tcatgagcta aacggaattt aattagctta tgaacccttt gccatacagg 9541 tccatcttct tttgaccaat ccattggctt acgacaatct ggatcattat ctccagccat 9601 ccccatttca gttccgtaat aaatacatgg actacctttt tgcatgaatt caaaagttaa 9661 tgcttgaagc gccaagtctt gatcaccttt tgcaactgtc aaaattctgg cagtatcatg 9721 tgaatcgagc atattcatca ttgcttcatt agtagaatca cgatatttca taagttgatc 9781 agtcaagcgt gtagtcattt gatcagcagt taacttatgc ttgaaaaagt ggtcttcaat 9841 ttgcaaagta tacggatagt tcattacacc tgtaaattca tcgccattaa gccatggacg 9901 agccgaatgc caaacttcac ctacaatgta aaagtctggc ttaatatcag tgactgcttt 9961 atggaacttc ttccagaagt gatgatcaac ttcatttgcc acatcaagac gccatgcatc 10021 gatatcaaaa tacttcaccc agtatgtagc aatttctaac aagaaatctt gaacctcagg 10081 attagcagta ttcaactttg gcatatgttc ttcaaaggca aaagtatcat attgcggatt 10141 cttttcgcct tttaatggat tacgatatgg ttcaactgga tactcattaa tatggaacca 10201 atctgcaaaa cgtgacttag atccattttg cactacatct tgccattgca ttgattgatc 10261 acctaagtga ttaaatacgg catcgagcat aatcttcata ccacgtgcat gtgcttcgtt 10321 aaccacttta gcaaataaat ctttatcacc aaattccgga tctacttgta aataatcaat 10381 cgtgtcatat ttatgattag agctcgcttt aaaaattgga caaaagtata aaccattaac 10441 gcctagcttt tgtaaataat ctaaatgatc taagacacct tgcaaatcac cgccataata 10501 atcctctcta ccaggatgat cagttggatt ccatggctta atattcttag gatcgtttga 10561 tttatcccca ttagcataac gttcagggaa tatctgatac caaacggtat tcttaaccca 10621 gtctggtgtt ttgaccatat caatttcatg acaatatgga attttaaaat atgatccatc 10681 ttcattgatt gcgtctttaa tatcatcgct aatcgcacgg tcaccataaa ctacacttgt 10741 accgtcctta ccaataactt caaaagtgta ctttaaacga tgatatggtg catcaagtgt 10801 aataccccaa tagtcttcaa cttgaccctc accgatcttt tccatttcag tagtttctgc 10861 aaattttaat ggtaaataat tatcacagta atgaacaatt actttttcaa catcattttt 10921 tgcagtgtga aaacgaacac gaacatgttt tggatcaact acaaaactat cttcactttc 10981 tgttctgtgt cttaaagcgg ctaattgcat acattaattc tcctttttca aaacaacacc 11041 cgcgtaaggc attaaagtta attttccatt agttaattga tattccccag cctttaatag 11101 ttctttaata tactcttccg gaagatcgat tgaaatcttt ttattactta acgaaacagc 11161 tacaatcgca ctctcattgc ccaaatcacg ttgataaacg taactgtcct taccagttga 11221 gatcatatag taagttccgt cttggaatag tttttctttt ttcagattca gcatattttt 11281 ataaaaagta aacatgctgt tatcagagtt gacttcattt gcaactgtta catcatcttg 11341 actaattcca ttgagccaag gtttagcact agtaaaacca ttattttctg tatcgttcca 11401 tggcattgga ccacgagccg gtaatttatg ggtatcgcta accatagcaa atgcggcatc 11461 tctacttatt ccagcttttt gtgcctcttt tatccatgga gcaacagttt gatcttcaaa 11521 ttgatcaaca ctagtaaagt gtaaattctt aagccctaat tcttcaccat aataaataat 11581 cggaataccg cgttgcagat acatcaacat tgctaagctc tttgcttgag ttgaagtctt 11641 cgcaattcta gtagcaagtc ttgccatatc gtgattattc caataaagcg tgggttgtga 11701 tatatcagct aacgtttgtt gccaaaccac ctgattttgt ttaaaagctg ttaaatcaag 11761 ctccttaggc tgatattgtg cggaataact cttatcgatt ttggaatcat cttctgtaaa 11821 ataacgaaat gtaatcacgc aatccattaa atgattacgt ttattcgtat aatcaactgc 11881 taagttaacg ctagcactag ctgcttcacc aagtaaaagt gcatctggat aatcttcttt 11941 aatttgttca caaaatggtc tcatccattc ttgcacttgt ggcaaattag caaaaaacgg 12001 ctctgcaata accggtttat catccatagc tggataattt tgtcttaagt ctgccttacc 12061 aatatgaata aatgcatcaa gtcttaagcc gtctattccc ttctttaacc aaaattcagc 12121 tatttcaagc atagcatgtc gaacttcagg gtttttccag ttaagatctg gcatccgttt 12181 atcaaataag tgaaaatatg actgaccagt acctgccgga tcaggttccc agacgcttcc 12241 tccaaagaaa gatccccaat tattaggttg tttattatca tgaccagcaa aaatgtagta 12301 atcacgatat aaactatccg gattcttaat agcatcttgg aaccatggat gttgatctga 12361 agtatgattt aagacaaaat ccataatgat atgaattcca gctttatgca gatctttaat 12421 taaattctcc atatcttcca tcgttcccat gtgagaatca atcgcaaaat aatttgagac 12481 atcataaccg ttatccactt gtggcgaaac aaaaacagga ttaagccaaa ctgcattaac 12541 tcctaaattt tgtaaatagg gaattctttt acgaatacca ttaagatcgc caataccatc 12601 gtcattgcta tcttgaaaag acttaggata aatttgataa ataattgcat gatcgtacca 12661 atgtgacata attttttcct ccacgcatag tttagccgaa taaagaaacc gttttcaaca 12721 tattgttaga tgttagcggt atcaaaaaac atccctttcg ggatgcactt ttaattgatg 12781 ttaacgcgtc aaacgaacta cttcacgagc aatcattaat tcttcgttag ttggcacaac 12841 caaggccttt accttggagt taggcattga aataaacttt tcgccatcgg ttctgttagc 12901 cttgtagtca ggctttaatc ctaaatacct caacgatgac atcactccag cacgaattcc 12961 agaatcatgt tctccaactc cggctgtgaa gataatccca tctacaccat ccatttcagc 13021 tgcataagca ccaacatacc ggacaacacg attaatataa atacgccgag caagttcagc 13081 acgtttttgt ttactttcaa taagatcacg catatctgac gacacaccag aaataccgag 13141 caaccctgac tcatgattta gcatatcgat tccttcatca atcgacatac cagttttatc 13201 cattatgtat cttaaagctg atggatcaaa gtcgccgctg cgtgtaccca ttgtcactcc 13261 agtaagcgga ctaaagccca ttgaagtatc atatgattta ccatttttta cagcagttac 13321 tgacgagcct gatcccaaat ggcaaactat taacttgcta atatttaaat ttttacccat 13381 cattttagct gcacgaggtg caacatattc gactgaaatg ccatgagcac cgtacttacg 13441 aactgcataa tcttcatagt acctatatgg aatagaatac aaataattaa tctcactaag 13501 actttgatga tacgatgtat caaatactgc gatttgcgga atatctggaa ttatctgcat 13561 aaaggcttct attccaactg tttcgggaat attgtgcaaa ggtgctaaat tacctaattt 13621 aataagctgc tttaaattcg cttgattaat gacgactgaa tgtttgaaaa cctcaccacc 13681 attaactact cggtgaccga caccagacaa ttctttcaga tctttaacca cgttaaattt 13741 ctttaagctt tcaattaaca aactaactgc agcttcttga ttaggaatag gcgtattttt 13801 gatgtattct ttactattaa gctttatttt aaataccgca ttagccatac caacacgatc 13861 tgccataccc gatgcaacta ctttttcatt aggaaaagta aacaacttat atttaaagga 13921 tgaactacct gaattaattg ctaaaacttt tttcataagt atgacctcta tttcaaaatt 13981 cgatatctgc cataaattcc cttttgtttt aaagtatagc gctttcattg ctgacatgga 14041 acgtttttat tcaataaaaa aatgcacagc aaccttgtag ttactgtaca tcttttttat 14101 cttgttgttt ctcgtctaat taattgtggt ttaaccatta attcaccttg aggtgagccg 14161 gattggtcaa ttttttgtaa taacatctta gcaagcatct tacccatttc aaaaatcggc 14221 tgctttatag ttgtcaattt aggattagac acctgatcca gaaatacgcc gtcaaaacca 14281 attacgccaa agtcttctgg aattcttgct ctttcatctt gcaattgtct aaccactccg 14341 acggcaatac ggtcacttgc acaaataaaa caagtatctt ttttaaattc tttaaaatgc 14401 tcatgtatta ccttttgtgc tgcatgacta tgattagata ctcgataaat ctgagggatt 14461 aatcgatgct gttgtaaagt attaatatat cccgcttcac gtgaatattc aaatggttct 14521 ttaatatcaa tcccaataaa aataatatgt ttgtataatc tgtccaatgc atattgggtc 14581 gccatttttt cagctgtttg attatccgta tcaacaaaat cataaccgcg gtgattttct 14641 ccaaataaga caaacggctt gtctagttta tcaaacatat cataatcttc attacgagcg 14701 cctgtaatca agtacccatc tgctcgtcct ttttcaattc tagtgggatc aactactaat 14761 tgcagcgcat attgcttggc atttaatcca cgagcaaaac caaaaagcag attagtataa 14821 taaggttctg ttgtatcaat atcttctaaa gtaacgaact ttactacatt agatcgattg 14881 ttaactaaag cttgtgcaat agaattaggg tgatagttca acttctccat agctttttca 14941 accattgcac gtaattctgg cgttacttgt tctggatgat taatcacccg tgatacggtc 15001 attttcgata catttgcttc tttagctaca tcagataaag ttgtcatatt ttcacct //