LOCUS AB812066 14841 bp DNA linear BCT 13-MAY-2015 DEFINITION Escherichia coli genes for O-antigen biosynthetic locus, partial sequence, strain: E110-69. ACCESSION AB812066 VERSION AB812066.1 KEYWORDS . SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 AUTHORS Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M., Hayashi,T. and Thomson,N.R. TITLE A complete view of the genetic diversity of the Escherichia coli O-antigen biosynthesis gene cluster JOURNAL DNA Res. 22 (1), 101-107 (2015) PUBMED 25428893 REMARK DOI:10.1093/dnares/dsu043 REFERENCE 2 (bases 1 to 14841) AUTHORS Iguchi,A., Iyoda,S. and Ohnishi,M. TITLE Direct Submission JOURNAL Submitted (02-APR-2013) Contact:Atsushi Iguchi University of Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1, Miyazaki, Miyazaki 889-2192, Japan FEATURES Location/Qualifiers source 1..14841 /organism="Escherichia coli" /mol_type="genomic DNA" /strain="E110-69" /db_xref="taxon:562" /note="serogroup:O160" gene <1..867 /gene="wcaM" CDS <1..867 /gene="wcaM" /codon_start=1 /transl_table=11 /product="colanic acid biosynthesis protein" /protein_id="BAQ01806.1" /translation="IVANITNCKFSDLQGDAIEWNVAINDSDILISDHVIERINCTNGK INWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKHFVIRNIKARNI TPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYLSIPQNFRVNNI QLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFMRNIRVMQESSV GPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNERGQSSVDIDRINHHIVNVEKINF RLPERRE" gene 1025..2020 /gene="gne" CDS 1025..2020 /gene="gne" /note="O160_01" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 4-epimerase" /protein_id="BAQ01807.1" /translation="MNDNVLLIGASGFVGTRLLETAIADFNIKNLDKQQSHFYPEITQI GDVRDQQALDQALAGFDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVKNI IFTSSVAVYGLNKHNPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIRPTV IFGERNRGNVYNLLKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGYEVYN YVDKPDLNMNQLVAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAVSSVRV KKFCATTQFDATKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE" gene 2263..3156 /gene="galF" CDS 2263..3156 /gene="galF" /note="O160_02" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="BAQ01808.1" /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIV AAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQ GEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVL AKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIW PELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNL KEGDKFRMSVKKLLEI" gene 3506..4753 /gene="wzx" CDS 3506..4753 /gene="wzx" /note="O160_03" /codon_start=1 /transl_table=11 /product="GT2|GT2_Glycos_transf_2" /protein_id="BAQ01809.1" /translation="MSLKKNVIYLVLMQAVNYIAPLVLVPYLTRILGVEKYGVLGLAIT VSQYLILLTDFGFNFTASRKIAQFKDSKVRVSQIFWTIISAKFLMMIVSFGLIVPFVVF SEKLNPLKWEIFLVSLSVVASVIIPSWLFQGLEKVTVFSGINIFSKILIVPLVFIFVKS KEDLLIACLLQGGVQVFSGIISILYVKYNKIISFKVVRPKLIFIYLKESLSVFLGNLSI SLYTLSTPLVLALMGTTYQVGLYSATDRIRGAAIGIFIVVGYAIFPRVSYLFKKNPLEA NVLLKKIIFIFSILGCLGGILVYSIADEIVLVAFGNQYLDSAILLKIMAPMFLLIPLSI IMANYLLLPNGFKKEYAKNSVIVCLLHMIYVFPLCKYYGAVGGSYSILISEIISFILLI FWTIKNNLLKKVFYAR" CDS 4743..5744 /note="O160_04" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01810.1" /translation="MQDNKSIKLSVIIPCWNCSKYITKTLDSIKYSYYMSRKPILEIIL VDDGSTDLTSKIIKAYDFGTRAVNVKYHFQNNAGPSKARNQGIKLAQGRYVTFLDSDDI WSPDYLRIIESIMDKYDSEIIEFNAVRFIEENANLKIHNNYTLVDEEYHGPINERILSE VFIKSEWYVWARVYKKKLLEGESFNENITHHEDAEFLPRIYLTAKSISRITSQLIYYRL TQNSITTKPKISSIKDLTLVCELYYENINGPNDKYYKAAMINCLWGLKRLILDKGEFSF IKKSRILYYCHIARNSSQLFNMLSWKKRLFIYLPRTYIFLNSLKYKLSKRGA" CDS 5744..6676 /note="O160_05" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01811.1" /translation="MEISIVIPLYNKENYIKRTLLSIIDTFGRVYNEKEYEIVIVDDGS KDKSVSVVESINSNVVKLYKQENGGPSKARNNGVNFSDGKYVIFCDADDIILPNYGDYI KYSIDNYPDHDVFVAFSRVLRNSKENYSIPLFDPVDVSIVDDFFYEWDKRKFFSASSIC IKKHFFIQNDLYFDETISSGEDLLMFYKAAIKTKYVAYSQPAVLYDKTVDSQLSSNPDL KIGAHTYFLIKVYKTENLSVKDKTAINRIIDKQICFVAVDNLLRKKYANSLNIVLFRKR MLLQPKLAIKLIIASISYKLFTKISSLLR" gene 6673..7773 /gene="wzy" CDS 6673..7773 /gene="wzy" /note="O160_06" /codon_start=1 /transl_table=11 /product="GT2|GT2_Glycos_transf_2" /protein_id="BAQ01812.1" /translation="MIIENNKVSSHSYLWVLFQSFIFYYKFMLQSWDGDEQIVNVISII LTLLLLCGTISAFIISNIKEKCIFLIIFIFVALNIIIADNKSVFWMVTAFTFLILFSTL TIKNRIRILVFSFIIAWCFFLPLQIFFSNSYTYIDDRYLRYTFGFLNPNGLGMFLLLLQ TLLYYWIWTSIKATIIVKQMITIILGGSIICIIFLSESRTYILLSFLLLILTVIYGFKK FKFSSRLLFIYLLFVMLLQWLSVKGFENYLIFQDMNAYMSGRVWFSYNLLSQMGEPKFF IGSDISLYQPIDFFFISLLYNNGILASLILLYCNYIFLKKLDNSTKYESILAFIFITVS FTEAVYNIPLLNFFFLLLYKKELRFS" CDS 7770..8789 /note="O160_07" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01813.1" /translation="MKVDAVILWVDGNDPKWQEEYNKYCKPASRIENGVQRYRDWDTLR YVIRGIEYNLPWIDKIHFVTCGQKPSWMVGYHPKLNFVHHNDIFENDTFLPTFNSSAIE LNLSRIKGLSERFIYFNDDMLVLKNTPLQRFFVNDLPVDFLIEAFPRRGLLYEKIRSNS TWVSMINNCTSLINRVYHKNKYIQDNRNLYYNMNYGRHVIANVLASPFKQFLAFKHYHH PQAYLKKTLQSVEREFPVEFNLTCKSRFREHDNISQALFRYYQLVTGSFYPCYYNDHAC VNVVNKKSASQCIEALHQKRFVCINDEINDDLDDSSILINDIIKELDLILPNKSSFEI" CDS 8796..9614 /note="O160_08" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ01814.1" /translation="MNSFDEFNVLLSLYKNESPDNLDACFQSISTQSLKRFKIILVIDG PISSELNEVVGKWKSLLPIKIINLERNVGLGNALNIGLKYCSCDYVFRMDTDDICHPDR FSIQFSYLRKHPDIDLLGGQIVEFHECIEEPNGMRLVPSKYEEILQYCKLKNPFNHMTV VFKRESVLKVGGYKHHLYMEDYNLWLRMISIGCKVENLDDVIVFARTDVNSLMRRRGWQ YVKSEWKLALLKIKLRINNPIVSLSVFILRSIPRLLPIMLIRRIYAHNRK" gene 9763..11169 /gene="gnd" CDS 9763..11169 /gene="gnd" /note="O160_09" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase" /protein_id="BAQ01815.1" /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAE NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGNTF FQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA EDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLSNEELAQTFTEW NNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLIT ESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQL RAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADD YQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDK EGVFHTEWLD" gene 12128..13294 /gene="ugd" CDS 12128..13294 /gene="ugd" /note="O160_11" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase" /protein_id="BAQ01816.1" /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPI VDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDV VEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGER SERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLG LNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANR TRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMK EDSFFNSRLERDLATFKQQAEVIISNRMAEELKDVADKVYTRDLFGSD" gene 13384..14418 /gene="wzz" CDS 13384..14418 /gene="wzz" /note="O160_12" /codon_start=1 /transl_table=11 /product="O-antigen chain length determinant protein" /protein_id="BAQ01817.1" /translation="MVIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQ LWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYTNAMNVIYGPAV PKVSDIQTSLIGRYSTAFSALAETLDNQEEPEKLTIEPTVKNQSLPLAVSYVGETAEGA QKQLAQYIQQVDDQVNEELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQIQEA LQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSSNYYQTRQNLL DIESLKVDDLDIHAYRYVMKPTLPIRRDSPKNAITLILAVLLGGMVGAGIVLGRNALRN YNAK" gene complement(14515..>14841) /gene="hisI" CDS complement(14515..>14841) /gene="hisI" /codon_start=1 /transl_table=11 /product="phosphoribosyl-AMP cyclohydrolase" /protein_id="BAQ01818.1" /translation="TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLR KRHQ" ORIGIN 1 atcgttgcca acatcaccaa ttgtaagttc agcgacttac agggcgacgc cattgaatgg 61 aacgtggcaa ttaacgacag tgatattttg atctccgacc atgtcatcga gcgcatcaac 121 tgtactaacg gaaaaatcaa ctggggcatt ggcataggcc ttgcggggag tacttatgat 181 aataactacc cggaagacca agcagtgaaa aactttgtcg tggcaaatat cacgggatcg 241 gattgtcggc agttgatcca tgttgaaaat ggcaaacatt ttgttatccg taatatcaaa 301 gcccgcaata tcacgccgga tttcagtaag aaagcaggca ttgataacgc gacagttgct 361 atttacggtt gtgacaattt cgtgattgat aatattgaaa tgattaatag cgccgggatg 421 ttaatcggct atggggtaat taaaggcaaa tatctctcga taccgcaaaa tttccgagtg 481 aataatattc aactggataa cacccatctt gcttataaat tgcgcggcat ccaaatctcc 541 gccgggaatg ctgtctcctt tgtggcactg actaacattg agatgaagcg tgcctcgctt 601 gagctacaca ataaaccgca acatcttttt atgcgaaata tcagagtgat gcaggaatcc 661 tcagttggac cagcattgag catgaacttt gacatgcgca aagacgttcg cggcgtgttt 721 atggcgaaaa aagaaacact gctgtctctt gcaaatgttc atgcggtgaa tgaaagaggg 781 caaagttccg tcgatatcga caggattaat caccatattg ttaatgtgga aaagattaac 841 tttagattgc cggaacggag ggagtagatt tgcgaccatt cataaactta ctggatataa 901 tgttctaaaa gattataatc ctcacactaa ctgttaaagc tggggctggg cagcattgac 961 tactcaggga aggtactcat ctttatcttg tgtttcttac gtaacaacca gactaaagtg 1021 atttatgaac gataacgttt tgctcatagg agcttccgga ttcgtaggaa cccgactact 1081 tgaaacggca attgctgact ttaatatcaa gaacctggac aaacagcaga gccactttta 1141 tccagaaatc acgcagattg gtgatgttcg tgatcaacag gcactcgacc aggcgttagc 1201 cggttttgac actgttgtac tactggcagc ggaacaccgc gatgacgtca gccctacttc 1261 tctctattat gatgtcaacg ttcagggtac ccgcaatgtg ctggcggcca tggaaaaaaa 1321 tggcgttaaa aatatcatct ttaccagttc cgttgctgtt tatggtttga acaaacacaa 1381 ccctgacgaa aaccatccac acgatccttt caaccactac ggcaaaagta agtggcaggc 1441 agaggaagtg ctgcgtgaat ggtataacaa agcaccaaca gaacgttcat taaccatcat 1501 ccgtcctacc gttatcttcg gtgaacggaa ccgcggtaac gtctataact tgctgaaaca 1561 gatcgctggc ggcaagttta tgatggtggg cgcagggact aactataagt ccatggctta 1621 tgttggaaac attgttgagt ttatcaagta caaactgaag aatgttgccg caggttatga 1681 ggtttataac tacgttgata agccagacct gaacatgaac cagttggttg ctgaagttga 1741 acaaagcctg aacaaaaaga tcccttctat gcacttgcct tacccactag gaatgctggg 1801 tggatattgt tttgatatcc tgagcaaaat tacgggcaaa aaatacgctg tcagctcagt 1861 gcgcgtgaaa aaattctgcg caacaacaca gtttgacgca acgaaagtgc attcttcagg 1921 ttttgtggca ccgtatacgc tgtcgcaagg tctggatcga actctgcagt atgaattcgt 1981 tcatgccaaa aaagacgaca taacgtttgt ttctgagtaa tgcagacgag tcagagaaaa 2041 aaggaccagg ttggactacg attattcgga aagaggtact gattaaatta tcagtatgcg 2101 gaattccgag taatccgagt aacccagatg ctgatggtgt gtagtgttat cctaaggttt 2161 aagcaaagtt atgcggaact aagctttggt atatagccat aacgtttggc taacctatgg 2221 caataattta cgcactatca gccacttaga ggtaggaaaa gaatgacgaa tttaaaagca 2281 gttataccgg tagcaggtct tgggatgcat atgttgcctg ccactaaggc gattcccaaa 2341 gagatgctac cgatcgtcga caagccaatg attcagtaca ttgttgacga gattgtggct 2401 gcagggatca aagaaatcct cctggtgact cacgcgtcca agaacgcggt cgaaaaccac 2461 ttcgacacct cttatgaatt agaatctctc cttgaacagc gcgtgaagcg tcaactgttg 2521 gcggaagtgc agtctatctg tccgcctggc gtgaccatta tgaacgtgcg tcagggcgaa 2581 cctttaggtt taggccactc cattttatgt gcacgacccg ccattggcga caacccattt 2641 gtcgtggtac tgccagacgt agtgatcgac gacgccagcg ctgacccgct gcgctacaac 2701 cttgctgcca tgattgcgcg cttcaatgaa acgggccgta gccaggtgct ggcaaaacgt 2761 atgccgggtg acctctctga atactctgtc atccagacca aagaaccgct tgatcgtgaa 2821 ggtaaagtca gccgcattgt tgaatttatc gaaaaaccgg atcagccgca gacgctggac 2881 tcagacatca tggctgttgg tcgctatgtg ctttctgccg atatttggcc ggaactagaa 2941 cgtactcagc ctggtgcatg gggacgtatt cagctgactg atgcaattgc tgagctggcg 3001 aaaaaacagt ccgttgatgc catgctgatg accggcgaca gttacgactg cggtaaaaaa 3061 atgggttata tgcaggcgtt tgtgaagtat gggcttagga atttaaagga aggtgataag 3121 ttcaggatga gtgtaaaaaa attgttagaa atctaactcc gaactattaa cgcgttcctt 3181 gggcgatagg ggacttaata cgattgtaat ggttaatcgt gtttcccctt ttttagattg 3241 attggtagtt ggaatggaaa ttttatattg agcaaaatat ggggaagata tattttagtt 3301 agttattaag agtacaatct gttgaatatt tgtttcgcta aataattgag ttttaggttt 3361 ttattaaaat ttataactat taatgagcat agtgcactgg tagctataga gccaggggcg 3421 gtagcttgtt tagtgttagg tattctggtt ttaaaagcat aaaactctcc agtattttca 3481 ttgcatacat aatattattc attaaatgtc attaaaaaaa aatgttatat atctagtgtt 3541 gatgcaagcg gttaattata ttgctcctct tgttttagta ccatatttaa cgcgaatcct 3601 tggagtggaa aaatatggcg ttctaggtct tgctattacg gttagccagt acttaatttt 3661 gttgacggat tttggtttta attttactgc cagtagaaaa atagctcaat ttaaagatag 3721 taaagtcagg gttagtcaaa tattttggac tatcatctca gcaaaatttt taatgatgat 3781 agtatcattc ggtttaattg tcccttttgt tgtgttttca gaaaaattaa atcccttaaa 3841 atgggaaata tttttagttt cgctatctgt agttgcgagt gtgattattc catcttggtt 3901 gtttcagggg cttgaaaagg ttacagtttt ttccggcatc aatatttttt ctaagatttt 3961 gattgtgcct cttgtcttta tttttgtgaa atctaaggag gatttactga ttgcctgctt 4021 attacaaggt ggagtgcaag tattttctgg aataatatcc atattgtatg ttaagtataa 4081 taagattatt tcatttaaag ttgtgaggcc aaaattaatc tttatatatt taaaagagtc 4141 tctatcagta tttttaggta atttatctat ttctttatat actctcagta cgcccttagt 4201 tttagctctt atggggacaa cgtatcaagt tgggctttat agtgccactg atagaatcag 4261 aggggctgca attggtatct ttatagttgt tggatatgca attttcccca gagtaagcta 4321 tttgtttaaa aaaaatccct tagaagctaa tgttttgctt aaaaaaataa tatttatctt 4381 ctcgattctg ggatgtttag gtggaatact tgtatatagt attgctgatg agattgtttt 4441 agttgcattt ggtaatcaat atttagattc tgccattctt ttgaaaataa tggcgcctat 4501 gtttttactc attcctcttt caataattat ggcaaactac ttattattgc caaatggttt 4561 taaaaaagag tatgcaaaaa attctgtgat agtatgctta ttgcatatga tatatgtttt 4621 ccctctttgt aaatactatg gtgcagttgg cggtagttat tcgattctta tttcagagat 4681 aataagcttt attttattaa ttttttggac gataaaaaat aatttattga agaaggtttt 4741 ttatgcaaga taataaaagt ataaaactaa gcgttataat accatgttgg aactgtagta 4801 aatatatcac aaaaacattg gattctatca aatattcata ttatatgtct agaaagccaa 4861 ttttagagat tattttagtg gatgatggct ctacagactt aacaagcaaa ataatcaaag 4921 cgtatgactt cggaactcga gcggttaatg ttaaatatca ttttcaaaat aacgccggtc 4981 ctagtaaggc acgaaatcaa ggaattaaat tagcgcaagg taggtatgtg actttcttgg 5041 attcggatga tatatggagt ccagattacc ttagaatcat agagtctata atggacaaat 5101 atgattctga aattattgaa tttaatgccg ttaggtttat tgaagaaaat gccaatttaa 5161 aaattcataa taattataca ttagtggacg aggagtatca tggtcctata aatgaacgta 5221 ttctttctga ggtttttata aaaagcgagt ggtatgtttg ggctcgtgtt tacaaaaaaa 5281 aacttttgga aggagagtcc ttcaatgaaa atattacaca tcatgaagat gctgaatttc 5341 taccacggat ttatcttaca gctaaatcaa tcagcagaat tacttcccag ttaatttatt 5401 atagattaac gcagaatagt attacaacaa aaccaaaaat tagtagcatc aaagatctca 5461 ctttagtatg cgaattgtat tatgaaaata tcaatgggcc aaatgacaaa tattataagg 5521 ctgcaatgat caactgtctc tggggtttaa aaagactaat ccttgataaa ggagaattta 5581 gttttataaa aaaaagtaga atattatatt actgccatat tgctagaaat agttcacaac 5641 tttttaatat gttaagttgg aaaaaaagat tatttattta tcttcctcga acctatatat 5701 ttttaaattc ccttaaatat aagctgtcaa aacgtggtgc ataatggaaa tatcaatagt 5761 aattccactg tataacaaag agaattatat caagaggacg ttgctttcaa taattgatac 5821 ttttgggaga gtctataacg agaaagagta tgaaatagtc atcgtggatg atgggtcaaa 5881 agataaaagt gtaagtgtag tagaaagtat aaatagtaat gttgtaaaac tctacaaaca 5941 agaaaatggc ggtccttcaa aagcaagaaa taatggtgta aatttcagtg atggaaaata 6001 tgtcattttt tgtgatgcag atgatattat tttaccaaat tatggtgatt atataaaata 6061 ttccattgat aattatcctg accatgatgt ttttgttgca tttagccgtg ttttaagaaa 6121 cagtaaagaa aattatagca tacctctttt tgaccccgtg gatgtttcta ttgttgatga 6181 ttttttctat gagtgggata agagaaagtt ttttagtgca tcgtcaattt gtataaaaaa 6241 acatttcttt atacaaaatg acttgtattt tgatgaaacg atttcatcag gtgaagattt 6301 attgatgttt tataaagctg cgattaaaac taaatatgtt gcctatagtc aaccggcagt 6361 attatatgat aaaacagtag attcgcagtt aagttctaat cctgatttga aaattggtgc 6421 acatacttat tttttaataa aagtctacaa aacagagaat ttatcagtca aagataaaac 6481 tgcaataaat cgaattatcg ataaacaaat atgctttgtt gcagtggata atctcttacg 6541 taaaaagtat gcaaattcgt taaatatagt attgttccgc aaacgaatgc ttttacaacc 6601 taaattagct ataaaattaa ttatagccag tatttcgtat aaacttttta ctaaaatatc 6661 tagtctacta agatgatcat agagaataat aaagtgagtt cacatagcta tttatgggtt 6721 cttttccaat cctttatatt ttattacaaa ttcatgctcc aaagttggga cggtgatgaa 6781 cagattgtaa atgtaatatc tatcatctta accttacttc ttttatgtgg tacgattagt 6841 gcttttataa tctcaaatat taaagagaaa tgtatatttt taataatttt catttttgtt 6901 gccttgaaca taattatagc agataacaaa tctgtctttt ggatggtgac ggcgttcact 6961 ttcttgatac tcttttcaac gttaaccatt aaaaatagaa ttaggatatt ggttttctct 7021 tttataattg catggtgttt ctttttacca ctacaaatat ttttctccaa ttcctataca 7081 tatattgatg atcgatattt aagatataca tttggatttt taaatcctaa tggattaggg 7141 atgtttctat tactgttgca gacactttta tattattgga tatggacttc aataaaagca 7201 acaataatcg tgaagcaaat gattacaata attttgggtg gatctatcat atgcataata 7261 tttttaagtg aatcaagaac atatatatta ctatcctttt tattactgat tttaactgta 7321 atatacggat ttaagaaatt taaattctca tcacgacttc tatttatata tttactgttt 7381 gttatgcttt tacaatggct ttctgtaaaa ggttttgaga attacctcat atttcaagat 7441 atgaacgcat atatgagtgg gcgagtctgg ttttcctata atttactaag ccaaatggga 7501 gaaccgaaat tctttattgg tagtgatatt tcattgtatc aaccgataga cttcttcttt 7561 atatcactat tatataataa tgggatactg gcttcgttaa tattgttata ctgtaactat 7621 atctttctaa aaaagttaga caactctacg aaatatgaaa gtatattagc ttttatattt 7681 attacagtaa gtttcacaga agctgtatat aatattcctc tgttgaattt cttctttttg 7741 ctgttatata aaaaggaatt gaggttttca tgaaagttga tgcagtaatc ttatgggtag 7801 atggtaatga tccaaaatgg caggaagaat acaataaata ttgtaagccg gcctctcgaa 7861 ttgagaatgg tgtacaaaga tatagagatt gggatacact acgatatgta attcgtggaa 7921 tagaatataa ccttccttgg attgacaaaa tacattttgt gacatgtggt caaaagccaa 7981 gttggatggt tggatatcat ccaaaactca attttgtaca tcataacgat atttttgaga 8041 atgatacatt tttacccaca tttaattcaa gtgcaataga gttaaatctg tcaaggataa 8101 agggattaag tgagaggttt atatatttta atgatgatat gcttgtgctt aaaaacactc 8161 ctcttcagag gttttttgta aatgatttac cggtggattt tttaattgaa gctttcccac 8221 ggcgtgggtt attgtatgaa aaaatacgtt ccaactcaac ttgggtttca atgataaata 8281 attgcacttc gctcataaat agagtgtatc acaagaataa atatatacag gataatcgta 8341 atttatatta taacatgaac tatggacgac atgtcattgc taatgtactg gcgtcccctt 8401 ttaagcagtt tttggctttt aaacactatc atcatcctca agcatatctt aaaaagacat 8461 tacaatccgt tgagcgtgag ttcccagtgg agtttaactt aacatgcaaa tctagattcc 8521 gagaacatga taatatctca caggcgttgt ttagatatta ccaattggta actggtagtt 8581 tttatccgtg ctattataat gatcatgcct gtgttaatgt agtaaataaa aaatctgcaa 8641 gccagtgtat tgaagctctt catcaaaaac gatttgtgtg tataaatgat gagattaatg 8701 acgacttaga tgatagttca attttaataa atgatataat taaagagttg gatttgattc 8761 ttccaaataa atcaagtttt gagatctaaa ttaatatgaa ttcgtttgat gagtttaatg 8821 tgctactatc tctttataaa aatgagagcc ccgataatct ggatgcgtgt tttcaaagca 8881 taagcactca atctttgaaa agatttaaaa taatacttgt catagatggt cctatttctt 8941 ctgagttaaa tgaggttgtc ggaaagtgga agtcactatt acctattaaa attatcaatc 9001 tcgaacgtaa tgttggctta ggtaatgctt taaatatagg tttgaaatat tgcagttgtg 9061 attatgtgtt tcgtatggat acagatgata tttgtcatcc ggataggttt tccatacaat 9121 ttagttatct gaggaaacac cccgatattg atttgcttgg tggacagatt gtagaattcc 9181 atgaatgcat agaggagcct aacggtatgc ggttagtacc ttctaaatat gaggaaattc 9241 ttcagtattg taaacttaaa aacccattta atcatatgac agttgtgttt aaaagagaga 9301 gtgtacttaa ggtcggtgga tataaacatc atttatatat ggaggattat aatctttggc 9361 ttcgtatgat atcaattggt tgcaaagtgg aaaatttaga tgatgtgatt gtttttgccc 9421 gaacagacgt gaattcatta atgagacgta gagggtggca atatgttaaa agtgaatgga 9481 aattagcact gttaaaaata aagttaagaa taaataatcc tattgtttct ttatctgttt 9541 ttatcctccg atctatacct cgattattac ctattatgtt gattcgtaga atttatgccc 9601 acaaccgcaa gtgaattttt ttaagtcata ttgagtaatt gagtaatagt tttcctatgt 9661 aatcaaaatt aactatcagt tttattatta gttgggtaat atctctctat atctcaacca 9721 gtgcagtcat tgcatggtga acacccctga caggagcaaa caatgtcaaa gcaacagatt 9781 ggcgtcgtcg gtatggcagt gatggggcgc aaccttgcgc tcaacatcga aagccgtggt 9841 tataccgtct ctattttcaa ccgttcccgt gaaaagacgg aagaagtgat tgccgaaaat 9901 ccaggcaaaa aactggttcc ttactatacg gtgaaagagt ttgttgaatc tctggaaacg 9961 cctcgtcgca tcctgttaat ggtgaaagca ggtgcaggca cggatgctgc tattgattcc 10021 ctcaagccat acctcgataa aggtgacatc atcattgatg gtggtaatac tttcttccag 10081 gacaccattc gtcgtaaccg tgaactttct gccgaaggct ttaacttcat tggtaccggt 10141 gtttccggtg gtgaagaagg cgcgctgaaa gggccttcca ttatgcctgg tggccagaaa 10201 gaagcctatg aactggttgc accgatcctc accaaaatcg ccgcagtggc tgaagacggt 10261 gagccatgcg ttacctatat tggtgccgat ggagcaggtc actatgtgaa gatggttcac 10321 aacggtattg aatacggcga tatgcagctg attgctgaag cctattctct gcttaaaggt 10381 ggcctgaatc tttccaacga agaactggcg cagacgttta ccgagtggaa taacggtgaa 10441 ctgagcagct acctgatcga catcaccaaa gatatcttca ccaaaaaaga tgaagacggt 10501 aactacctgg ttgatgtgat tctggatgaa gcagcaaaca aaggtacggg caaatggacc 10561 agccagagtg cgctggatct cggcgaaccg ttgtcgctga ttaccgagtc tgtgtttgct 10621 cgttatatct cttctctgaa agatcagcgt gttgccgcat ctaaagttct ctctggcccg 10681 caagcacagc cagcaggcga caaggctgag ttcatcgaaa aagttcgtcg tgcgctgtat 10741 ctgggcaaaa tcgtttctta cgcccagggc ttctctcagc tgcgtgctgc gtctgaagag 10801 tacaactggg atctgaacta cggcgaaatc gcgaagattt tccgtgctgg ttgcatcatc 10861 cgtgcgcagt tcctgcagaa aatcaccgat gcatacgccg aaaatccgca gatcgctaat 10921 ctgctgctgg ctccgtactt caagcaaatt gccgatgact accagcaggc gctgcgcgat 10981 gtcgtcgctt atgcggtaca gaacggtatc ccggttccga ccttcgccgc tgcggttgcc 11041 tattatgaca gctaccgcgc cgcagttctg cctgcgaacc tgatccaggc acagcgtgac 11101 tatttcggtg cgcatactta taagcgcatt gataaagaag gtgtgttcca taccgaatgg 11161 ttggattaat ctgatctaac caacaataaa tttaggcccg gcgtatattg cgccgggctt 11221 tttgtgcaca gaaaaccccc agctaggctg ggggttccgg aaagctatca gctttgagcc 11281 agttattaaa accccttttg atttgttaaa acaccttgcg gtctggcaac tgcaagtgtc 11341 aaacaagaaa tcaaaagggg gtcccaatgg ggaacgaaaa gagcttagcg cacacccgat 11401 ggaactgtaa atatcacata gtttttgcgc caaaatactg aagacaagtg ttctacagag 11461 agaaacgtag agcaataggc agtattttga gaaagctgtg tgagtggaaa agcgtacgga 11521 ttcttgaaac tgaatgctgt gcagatcata tccatatgct tgtggagagc ccgcccaaaa 11581 tgagcgtatc cggctttatg ggatatctga aagggaaaag cagtctgatg ctttacgagc 11641 agtttgatga tttgaaattc aaatacagga acagggagtt ctggtgcaga gggtactacg 11701 tcgatacggt gggtaagaac acggcgaaga tacaggatta cataaagcac cagcttgaag 11761 aggataaaat gggagagcag ttatcgattc cctatccggg cagcccgttt acgggccgta 11821 agtaacgaag ttggatacaa atgtcagatc gtgtgcgcct gttagggcgc ggctggtaag 11881 agagccttat aggtgcattt gaaaaacctc cggctatgcc ggaggatatt tatttttgcc 11941 aattatctta tagactaaat ttcactgctt aatattaact taataaatat cggctattct 12001 tataaagaaa atctgaattg tttttcgttg cgttgaccat ctgacaacgt agcgttaaaa 12061 cttttagctc ttatcaggat gctaaaaaca tcatgattca cagttaagtt aattctgaga 12121 gcatgaaatg aaaatcacca tttccggtac tggctatgta ggcttgtcaa acgggcttct 12181 aatcgcacaa aatcatgagg ttgtggcatt agatatttta ccgtcacgcg ttgctatgct 12241 gaatgatcgg atatctccta ttgttgataa ggaaattcag cagtttttgc aatcagataa 12301 aatacacttt aatgccacat tagataaaaa tgaagcctac cgggatgctg attatgtcat 12361 catcgccact ccaaccgact atgatcctaa aactaattat ttcaatacat ccagtgtaga 12421 atcagtaatt aaagacgtag ttgagataaa tccttatgcg gttatggtca tcaaatcaac 12481 ggttcccgtt ggttttaccg cagcgatgca taagaaatat cgtactgaaa atattatttt 12541 ctctccggaa ttcctccgcg aaggtaaagc cctttacgat aatctccatc cgtcacgtat 12601 tgtcatcggt gagcgttcag aacgcgcaga acgttttgct gcgttattac aggaaggcgc 12661 gattaagcaa aatatcccga ccctgtttac cgattcaacc gaagcagaag cgattaaact 12721 tttcgctaat acctatctgg cgatgcgcgt agcatacttt aatgaactgg atagctatgc 12781 agaaagttta ggtctgaata ctcgccagat tatcgaaggc gtttgtctcg atccgcgtat 12841 tggcaaccat tacaacaatc cgtcgtttgg ttatggtggt tattgtctgc cgaaagatac 12901 caagcagtta ttggcgaact accagtctgt gccgaataac ctgatttcgg caattgtcga 12961 tgctaaccgc acgcgtaaag actttattgc cgatgccatt ttgtcacgca aaccgcaagt 13021 ggtgggtatt tatcgtctga ttatgaagag cgggtcagat aacttccgtg cgtcttccat 13081 tcaggggatt atgaaacgta tcaaggcgaa aggcgttgaa gtgatcattt acgaaccggt 13141 gatgaaagaa gactcgttct tcaactctcg gctggaacgt gatctcgcca ctttcaaaca 13201 acaagccgaa gtcattattt ccaaccgtat ggcagaagag cttaaggatg tggcagacaa 13261 agtctacacc cgcgatctct ttggcagtga ctaacatcct gttatcaggg cgattttcgc 13321 cctgattctc ttatgttccc tttgtaataa ttcattattt ttatcattta tcctatagca 13381 ttcatggtga ttatcgctaa actatggcga cttaaaatta tttcgtccgt tagggtaatg 13441 atgagagtag aaaataataa tgtttctggg caaaaccatg acccggaaca gattgatttg 13501 attgatttac tggtgcagtt gtggcgcggc aagatgacaa ttatcatctc tgtcattgtc 13561 gctattgccc tggctatagg gtatttggcc gttgccaaag aaaagtggac ttccacagct 13621 atcgttactc aacctgatgt ggggcaaatc gctggttata ccaacgcgat gaatgtgatt 13681 tacggtccgg ctgtaccgaa agtctccgac attcagactt cacttatcgg acgttacagc 13741 actgcattct cagcattagc ggaaacgctg gataatcagg aagaacctga aaaactgacc 13801 attgagccta ccgttaaaaa tcagtcctta cctttagcgg tttcttatgt tggtgaaaca 13861 gctgaaggtg cgcagaaaca gctggcgcag tatatccagc aagttgacga ccaggtaaac 13921 gaagaactgg aaaaagacct gaaagacaac atcgcactgc gtatgaaaaa cttgcaggat 13981 tcgcttaaga cccaggaagt ggttgcgcag gagcagaaag atctgcgtat ccgtcagatt 14041 caggaagcgt tgcagtatgc gaatcaggcg caggtgacaa aaccacaggt tcagcagact 14101 gaagatgtga cgcaagatac gttgttcctt ttggggagcg aagcgctgga gtcgatgatt 14161 aagcatgagg cgacccgtcc gttggtgttc tcatcaaact actatcagac acgtcaaaac 14221 ctgctggata tcgaaagctt aaaggttgat gatcttgata ttcatgctta ccgctatgta 14281 atgaaaccga cgttacctat tcgtcgcgat agcccgaaaa acgcaattac cttgattttg 14341 gcggtgctgc tgggcggcat ggttggcgcg gggattgtgc tggggcgtaa cgctctgcgt 14401 aattacaacg cgaaataatc tttgcagctt taaagaaaac gggcagggtg gtgacacctt 14461 gtccgttttt tttgccggat gcgacaacaa catcgcatcc gcttaccccg ccactcactg 14521 atgccgttta cgcaggttct caattaccgt cgttaaatcc agatcctgat cctgcaacaa 14581 caccagcagg tgatacatca agtcagatgc ctcgttggtc agctcaaagc ggtcatgtac 14641 cgttgcagcc agtgcggttt ccacgccttc ttcgcccact ttctgcgcaa tgcgtttggt 14701 gccgctggca tacagtttgg cggtgtagga ggtttccggg tcggcagatt tgcgttcggc 14761 gagcagttgt tccagttgat acaggaacag ccactggtga gcggtgtcgc cgaagcagct 14821 gctggtgcct ttgtggcagg t //