LOCUS AB811614 19104 bp DNA linear BCT 13-MAY-2015 DEFINITION Escherichia coli DNA, O-antigen biosynthetic locus, strain: H510c. ACCESSION AB811614 VERSION AB811614.1 KEYWORDS . SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 AUTHORS Iguchi,A., Iyoda,S., Kikuchi,T., Ogura,Y., Katsura,K., Ohnishi,M., Hayashi,T. and Thomson,N.R. TITLE A complete view of the genetic diversity of the Escherichia coli O-antigen biosynthesis gene cluster JOURNAL DNA Res. 22 (1), 101-107 (2015) PUBMED 25428893 REMARK DOI:10.1093/dnares/dsu043 REFERENCE 2 (bases 1 to 19104) AUTHORS Iguchi,A., Iyoda,S. and Ohnishi,M. TITLE Direct Submission JOURNAL Submitted (29-MAR-2013) Contact:Atsushi Iguchi University of Miyazaki, Faculty of Agriculture; Gakuen-kibanadai-nishi 1-1, Miyazaki, Miyazaki 889-2192, Japan FEATURES Location/Qualifiers source 1..19104 /organism="Escherichia coli" /mol_type="genomic DNA" /strain="H510c" /db_xref="taxon:562" /note="serogroup:O37" gene <1..901 /gene="wcaM" CDS <1..901 /gene="wcaM" /codon_start=2 /transl_table=11 /protein_id="BAQ00839.1" /translation="AILRQGFHNQIIGANITNCKFSDLQGDAIEWNVAIHDSDILISDH LIERINCTNGKINWGIGIGLAGSTYDNNYPEDQAVKNFVVANITGSDCRQLIHVENGKH FVIRNIKARNITPDFSKKAGIDNATVAIYGCDNFVIDNIEMINSAGMLIGYGVIKGKYL SIPQNFRVNNIQLDNTHLAYKLRGIQISAGNAVSFVALTNIEMKRASLELHNKPQHLFM RNIKVMQESSVGPALSMNFDMRKDVRGVFMAKKETLLSLANVHAVNERGQSSVDIDRIN HHIVNVEKINFRLPERRE" gene 1059..2054 /gene="gne" CDS 1059..2054 /gene="gne" /note="O037_01" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 4-epimerase" /protein_id="BAQ00840.1" /translation="MNDNVLLIGASGFVGTRLLETAIADFNIKNLDKQQSHFYPEITQI GDVRDQQALDQALAGFDTVVLLAAEHRDDVSPTSLYYDVNVQGTRNVLAAMEKNGVKNI IFTSSVAVYGLNKHNPDENHPHDPFNHYGKSKWQAEEVLREWYNKAPTERSLTIIRPTV IFGERNRGNVYNLLKQIAGGKFMMVGAGTNYKSMAYVGNIVEFIKYKLKNVAAGYEVYN YVDKPDLNMNQLVAEVEQSLNKKIPSMHLPYPLGMLGGYCFDILSKITGKKYAVSSVRV KKFCATTQFDATKVHSSGFVAPYTLSQGLDRTLQYEFVHAKKDDITFVSE" gene 2297..3190 /gene="galF" CDS 2297..3190 /gene="galF" /note="O037_02" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="BAQ00841.1" /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIV AAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQ GEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVL AKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIW PELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNL KEGAKFRKGIEKLLSE" CDS 6722..7777 /note="O037_06" /codon_start=1 /transl_table=11 /product="putative UDP-glucose 4-epimerase" /protein_id="BAQ00842.1" /translation="MSILVTGGCGYIGIHTIFTLITQGHSVVVLDNLTNSSIEPLKRVE LMANCNIPFYKGNVGDKRLLVEVFNKHQITAVIHFAGLKSVSESMKKPIEYYSNNVTQT LSLLESMIDNNIKSFIFSSSATVYGKPNECPIKESHKIGNTTNPYGTSKFIMELMLSDL CEAYNDLNITILRYFNPIGAHESGNIGEHPNGVPNNLFPYLMKVAIGEYPYLNVYGNDY STYDGSGIRDYIHVVDLAEAHAKALSKNLVVDGLKIYNLGTGKGYSVFEVIETFEKITG IKIPYRVMPRRDGDVAECWSNSLKANEELEWKATKDLSDMVRDAWNWQLKNPHGYDNDE VMLLDSKMDDL" CDS 8301..8693 /note="O037_07" /codon_start=1 /transl_table=11 /product="putative glycerol-3-phosphate cytidyltransferase" /protein_id="BAQ00843.1" /translation="MKKVITFGTFDVFHVGHINILERASKLGDYLIVGVSSDKLNFSKK NRFPIYSEKDRVKIISSLRFVNEVFIEESLELKLEYIKKYNVDLLVMGDDWAGKFDWVK SNCEVIYLPRTPSISTTEIIEIVRSI" gene 8695..9927 /gene="wzx" CDS 8695..9927 /gene="wzx" /note="O037_08" /codon_start=1 /transl_table=11 /product="O-antigen flippase" /protein_id="BAQ00844.1" /translation="MFRRIISHRVFKNSFALFIMQLFSYVSPLLVLPYLARIMSVENFG MLMMLYSLLAICLVVTDFGFNLSGTYYISRNYKNKKKINEFLTSVFCIKIILSTASVIF FLVFFRGEFQRLDKYSVLLIAITMFVQSFQPIWFFQGIEKMRHITIYTALSKLIYLLLV FLFVTSDSIVTVLLCYCISQMVGTFFSICFILKMKYSFSRTTYKNIISVFRQSIPFFVS RVAVVVYTSANTLFLGKYGGMAQAASYSSCEKIYFAGQSLLNPLSQAFFPYLSKNRDAK FYIKFVILSVCILSVICAVASFFVYDFLNIFYGQKYNDSIGILNTFLITTVIAYTSVSF GYPMYTLIDKIGYVNHTVIIGAVIHIIGLFILAKENIFTAQNIAYLVLIVETSVLITRV FLYTYLKIKRV" CDS 9927..10655 /note="O037_09" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="BAQ00845.1" /translation="MELFNLINYSLYNSIIGRSYRKILRVFERNKNINKAQYGEMVVND VMKLNYNYFPMFGTLLSLHRDGRFVFADDFDFAIIGDFPEDIISTFERNGYQLCALSLI GNKREIIEYSFSKKIKNEYIKVDIFKLKEVNNIIRHSCPNFRKEKEFVRFRDGLKICQF NSYFTVDYPKFDLTVSKWGIKIPNNPDDIFELHYGHDWEIPKTSNFIDFSAYRFIAERS ETVLGPSEKLKEYIKNNMSC" gene 10658..11791 /gene="wzy" CDS 10658..11791 /gene="wzy" /note="O037_10" /codon_start=1 /transl_table=11 /product="GT2_Glycos_transf_2|GT2" /protein_id="BAQ00846.1" /translation="MIRLQNIILFVLLAFSGVYVSSWLIKPSYVAVIISFFILTILTLR GVRYSFSSSIFILIAICVFYTIFNQFALEGELPTIIFYSCLILIPLLVSTFKSSTSKSN ILLVSYIILIIYYSFETFIRITNPDYSHLPKTGDDGITSTFYIYKINSIAFEDSNFISV ILVVYYISLRSTALYSDIKVKYSLGLNIGLLTLILLTFSRSAYIGVLIFECMVLFFFKP DVNMKLRGLLVSIILVGGGICAHFIIEKIASDPSFISKFYIVDLTVKYLSHASTLDILF GIGFGNAINVLGMGAHNIFIAIFIENGLIGTLLYLYILIMLSIRYKLTMLLIIPISIMG LSFSQIAMPYFYVVIAWLIFVNEDRCEKISKCCNAHL" CDS 11778..12668 /note="O037_11" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ00847.1" /translation="MPTYNNEKYIKSAIDDIMNQTYQYWELIIINDGSTDNTCQILSEY NKVNNIHIINLVANKGICEALNVGLKIAKGDFILRFDADDRCSSDRISKLLEYMLKNNI DIVGSSVITINENDDVIGKAVFSDNERIISRLIRYENPILHIWLAKREVYDKLGGYRIG GVEDYDFILRALDSGYKVSNISDYFGISIRKHSRNTANTQGWRQRKCFNLAWTLHKERL KKGYEVTSSIPRYGRFIKYGDKIHAISNKLLVKGISSKKLSYKIAIIVAAAVISPYQFQ YLIYRFIGKIIKKTL" CDS 12665..13732 /note="O037_12" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ00848.1" /translation="MKILYIIPSLKKCGPVNVCLSLAKNISENHSVSILAFRNGNSFND FYSCCDNVKIIPIYNLFAIARFIAAEKFQIIHSHCLVPDFLLSLFSFFFRNKFIPISTI HNYIDIDYIFSKGLFIGKLMGVINRLSLSKIKNLVSCSLAVKYYCDVAYDIRSTAISNG VPISPYIDEMQQECNKKFIDFYYVGVLTERKNVDLLIQSFHLYKRKYKNEDRLHVIGGG ELLEVLKKNNKCDYIIFYGPQVNPWPIIKSLDIYVSSSRAEGMPLALLEALSIGKAYIC SNIEPHCEVHHVVNGGIICSFDKDDFVKAFHHMRYWDLKPKNEYILERFKNNYADYIMA GKYLIKYEELLKEHE" CDS 13704..14540 /note="O037_13" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="BAQ00849.1" /translation="MRSYSRNMNDIRFSVLMSLYKNESEKFLDDCFSSVYDQTLPANEI TLVIDGPIPNSLEYVVLKWMVFLPINVVRLEKNVGLGQALNYGIKACSNDIIIRMDTDD ICKRNRFEVLVKKLNSNNRLAVVGSCIEEFVHLPSNIISVRTVPLDPESIRKEILVRNP FNHMSVAFRKKFIESVGGYVHHHFMEDYNLWLRVVASGFDVCNINESLILARVGDNMLA RRKGLRYIKSEFQLYRLKVKLGLQSHISGFCILLVRSIPRLLPLKVLKIIYQYIRK" gene 14655..16061 /gene="gnd" CDS 14655..16061 /gene="gnd" /note="O037_14" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase" /protein_id="BAQ00850.1" /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTEEVIAE NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLNKGDIIIDGGNTF FQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILTKIAAVA EDGEPCVTYIGTDGAGHYVKMVHNGIEYGDMQLIAEAYSLLKGGLNLTNEELAQTFTEW NNGELSSYLIDITKDIFTKKDEDGNYLVDVILDEAANKGTGKWTSQSALDLGEPLSLIT ESVFARYISSLKEQRVAASKVLSGPQAQPAGDKGEFIEKVRRALYLGKIVSYAQGFSQL RAASEEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAENPQIANLLLAPYFKQIADD YQQALRDVVAYAVQNGIPVPTFAAAVAYYDSYRAAVLPANLIQAQRDYFGAHTYKRIDK EGVFHTEWLD" gene 16310..17476 /gene="ugd" CDS 16310..17476 /gene="ugd" /note="O037_15" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase" /protein_id="BAQ00851.1" /translation="MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPI VDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDV VEINPYAVMVIKSTVPVGFTAAMHKEYRTENIIFSPEFLREGKALYDNLHPSRIVIGER SERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLG LNTRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANR TRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMK EDTFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD" gene 17566..18600 /gene="wzz" CDS 17566..18600 /gene="wzz" /note="O037_16" /codon_start=1 /transl_table=11 /product="O-antigen chain length determinant protein" /protein_id="BAQ00852.1" /translation="MAIIAKLWRLKIISSVRVMMRVENNNVSGQNHDPEQIDLIDLLVQ LWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIVTQPDVGQIAGYTNAMNVIYGSAV PKVSDIQASLIGRYSTAFSALAETLDNQEEAEKLTIEPTVKNQSLPLAVSYVGETPEGA QKQLAKYIQQVDDQVNEELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKDLRIRQIQEA LQYANQAQVTKPQVQQTEDVTQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLL DIESLKVDDLDIHAYRYVMKPMLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRN YNAK" gene complement(18772..>19104) /gene="hisI" CDS complement(18772..>19104) /gene="hisI" /codon_start=1 /transl_table=11 /protein_id="BAQ00853.1" /translation="GPTXHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKL YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIEN LRKRHQ" ORIGIN 1 cgccatctta cgccagggat ttcataacca gattatcggt gccaacatca ccaactgtaa 61 gttcagcgac ttacagggcg acgctattga atggaacgtg gcgattcacg acagtgatat 121 tttgatatcc gaccatctca ttgagcgcat taactgtacc aacggcaaaa tcaactgggg 181 catcggtata ggccttgcgg gaagtaccta cgataacaac tacccggaag accaggcagt 241 gaaaaacttt gtcgtggcga atatcacggg atcggattgt cggcagttga tccatgttga 301 aaatggtaaa cattttgtta ttcgtaatat caaagcccgc aatatcacgc cggatttcag 361 taagaaagca ggtattgata acgccacggt tgctatttac ggttgtgata atttcgtgat 421 tgataatatt gaaatgatta atagcgccgg gatgttaatc ggttatgggg taattaaagg 481 caaatatctc tcgataccgc aaaatttccg ggtgaataat attcaactgg ataataccca 541 ccttgcttac aaattgcgcg gtatccaaat ctctgccggg aatgccgtct cctttgtggc 601 gctgactaac attgagatga agcgtgcgtc gctggagtta cacaacaaac cgcaacatct 661 ttttatgcgt aatatcaagg tgatgcagga atcctctgtt ggacccgcat tgagcatgaa 721 cttcgacatg cgcaaagacg ttcgcggcgt ctttatggcg aaaaaagaaa cactgctgtc 781 tcttgcaaat gttcatgcgg tgaatgaaag agggcaaagc tccgtcgata tcgacaggat 841 taatcaccat attgttaatg tggaaaagat taactttaga ttgccggaac ggagagagta 901 gatttgcgac cattcataaa cttactggat ataatgttct aaaagattat aatcctcaca 961 ctaactgtta aagctggggc tgggcagcat tgactactca gggaaggtac tcatctttat 1021 cttgtgtttc ttacgtaaca accagactaa agtgatttat gaacgataac gttttgctca 1081 taggagcttc cggattcgta ggaacccgac tacttgaaac ggcaattgct gactttaata 1141 tcaagaacct ggacaaacag cagagccact tttatccaga aatcacacag attggcgatg 1201 ttcgtgatca acaggcactc gaccaggcgt tagccggttt tgacactgtt gtactactgg 1261 cagcggaaca ccgcgatgac gtcagcccta cttctctcta ttatgatgtc aacgttcagg 1321 gtacccgcaa tgtgctggcg gccatggaaa aaaatggcgt taaaaatatc atctttacca 1381 gttccgttgc tgtttatggt ttgaacaaac acaaccctga cgaaaaccat ccacacgatc 1441 ctttcaacca ctacggcaaa agtaagtggc aggcggagga agtgctgcgt gaatggtata 1501 acaaagcacc aacagaacgt tcattaacta tcatccgtcc taccgttatc ttcggtgaac 1561 gcaaccgcgg taacgtctat aacttgctga aacagatcgc tggcggcaag tttatgatgg 1621 tgggcgcagg gactaactat aagtccatgg cttatgttgg aaacattgtt gagtttatca 1681 agtacaaact gaagaatgtt gccgcaggtt atgaggttta taactacgtt gataagccag 1741 acctgaacat gaaccagttg gttgctgaag ttgaacaaag cctgaacaaa aagatccctt 1801 ctatgcactt gccttaccca ctaggaatgc tgggtggata ttgctttgat atcctgagca 1861 aaattacggg caaaaaatac gctgtcagct cagtgcgcgt gaaaaaattc tgcgcaacaa 1921 cacagtttga cgcaacgaaa gtgcattctt caggttttgt ggcaccgtat acgctgtcgc 1981 aaggtctgga tcgaacactg cagtatgaat tcgttcatgc caaaaaagac gacataacgt 2041 ttgtttctga gtaatgcaga cgagtcagag aaaaaaggac caggttggac tacgattatt 2101 cggaaagagg tactgattaa attatcagta tgcggaattc cgagtaatcc gagtaaccca 2161 gatgctgatg gtgtgtagtg ttattctaag gtttaagcaa agttatgcgg aactaagctt 2221 tggtatatag ccataacgtt tggctaacct atggcaataa tttacgcact atcagccact 2281 tagaggtagg aaaagaatga cgaatttaaa agcagttata ccggtagcag gtcttgggat 2341 gcatatgttg cctgccacta aggcgattcc caaagagatg ctaccgatcg tcgacaagcc 2401 aatgattcag tacattgttg acgagattgt ggctgcaggg atcaaagaaa tcctcctggt 2461 aactcacgcg tccaagaacg cagtcgaaaa ccacttcgac acctcttatg aattagaatc 2521 tctccttgaa cagcgcgtga agcgtcaact gctggcggaa gtacagtcta tctgtccgcc 2581 gggcgtgacc attatgaacg tgcgtcaggg cgaaccttta ggtttaggcc actccatttt 2641 gtgtgcacga cccgccattg gtgacaaccc atttgtcgtg gtattgccgg acgttgtgat 2701 cgacgacgcc agtgccgacc cgctgcgcta caaccttgct gccatgattg cacgtttcaa 2761 cgaaacgggc cgcagccagg tgctggcaaa acgtatgccg ggtgacctct ctgaatactc 2821 cgtcattcag actaaagagc cgctggatcg tgaaggtaaa gtcagccgta ttgttgaatt 2881 catagaaaag ccggatcagc cgcagacgct ggactcagac atcatggccg ttggtcgata 2941 tgtgctttct gccgatattt ggccggaact tgaacgcact cagcctggtg catgggggcg 3001 tattcagctg actgatgcca ttgccgaact ggcgaaaaaa cagtccgttg atgccatgct 3061 gatgactggt gacagctatg actgcggtaa aaaaatgggt tatatgcagg cgtttgtgaa 3121 gtatggactg cgcaacctca aagaaggggc gaagttccgc aaaggcattg agaaactgtt 3181 aagcgaataa tgaaaatctg accgaatgtg acggttggca aggaaactat aacagcagtg 3241 aagattcgtg gcgaaagtaa tttgttgcga atattcctgc cgttattttg tataaacaat 3301 cagaataaca aatagttagc aataggcttt tcgtcaaagt tttcctggat tttccttgtt 3361 tccagaacgg attggtaaga caattagcgt atgaattttt cgggtttggc gcgagtgggt 3421 aacgctcgcc acatcgtagg catgcatgca gtgctctggt agctgtaaag ccaggggcgg 3481 tagcgttcag tgaaatatta cgtgatgctg cagtgtactt aataattcgt aaactatgtt 3541 caaggattga tgcgtccctt atcgtctaaa tcgtctttca caacttatat atggttgaat 3601 acctattata taaataagtt agagaattga tggacatatt tcttttatcc cccgattaaa 3661 gacaagccta ggaagtagaa catatattgt ctgatattct actgttgact atttgcaccg 3721 ttattttggt acagaaggtt gggaagatat agaggatttt gggaaaacac ctctcgattt 3781 tttgaagcaa tatggtgatt ttgaaaatgg tattcctgtt cacgatacca ttgctagagt 3841 tgtatcctgt atcagtcctg caaaatttcg cgaatgcttt attaactgga tgcgtgactg 3901 tcattcatca gatgataaag atgtcatcgc aattgattga aaaacactcc gctattctta 3961 tggtaagagt cgccgcaggg gagcgattca tgtcattggt gtgttctcaa caatgcacag 4021 tctggtcatc ggacagatca aggcggataa gaaatccaat gagagtgtgc cgtgggggtt 4081 gaaactagcc tgcttggata acagtcagtg gtgaacataa gcttgtgaag agaaggaggt 4141 cggccttcca gagtcgatgg tcggaggttg actctaaacc cccttcaggt ggctgtcatt 4201 aagagtgatg gtcagaagcg ttgaagggaa atcagaataa gattctggcg aggtaagatg 4261 taaggagagg agtaaccccg aacctgtgtt gacacgtcgt tatctttaaa atggcatcgg 4321 aactgaggtc gtctcgttat ctctggataa gcacactggc gaagtccgaa tgttgagtgt 4381 gcggtgtccg gcgtaaagca ggcatgacct tatatcaggc tctttgtagt aaccacggga 4441 accagtcatc atgatgttaa ggaagaaagg taaatcaccg aaatgataag cctgtgagta 4501 ccgaagcatg atactggggc ggagcaactt gtagcagtga ggaagcattt gtaatgagtg 4561 tggaacgaag ggagggcgtt aagcagtctg aaccggcatc tcaactgtca caatgtggca 4621 ggaggaaggc gtgcgggcag gcaaaaccat ttgcgatcta aaaatgggaa gtgcaggccg 4681 cgtttgataa agtgaaagcg aatcaaggcg gggcgggtat tgatggtgta acgcttgaga 4741 tgtttgaaag aaatcttaat aacaacctgt ataagatatg gaatcgtcta tcatttgaaa 4801 cgtattttgc tccgtcagta aaagcggtca atataccgaa gaaaacaggt ggagtaagag 4861 cgttaggtat tccgacggtt gtgatcgggt agcgcagatg gtgattaaag agcgacttga 4921 ggcaataata gaaccctgtt ttctgagtga ttcctatggt tacagatcgg caaaatcagc 4981 gattcaggct attggtgtaa caagaaaacg ctgttgggaa tataattgga ttctgtagtt 5041 tgatatcaaa ggtctgtttg ataatatacg gcatgattta ctgcttaaag cagttgaaaa 5101 acatgttgct aatggttctc aaattcaagg gcaagagctg agtttgctca ccttctatat 5161 aaaacgatgg ttagtttcac cattgcagca ggatgacggg aatattatct tgcgagattg 5221 gggacaccac aagggggctt agtcagctca cttctggcga atttattttc acactatgtt 5281 tttgataaat ggatgcagag agaatttccc gaaaatccgt ggtgtcgata tgcagatgat 5341 ggactggttc atgctatcac taaaggcaaa gcagaatcac tgtatgaaag gataaaacgc 5401 cgtttggaag agtgtggtct cgaattacat ccagaaaaga cgaaaataat atattgtaag 5461 gacgataaaa gaaagtgaac atgtgttcac actagcttcg attttatggg atatacattc 5521 agacaaagaa gatgtaggaa atgctcacat aatacattct tcaatagctt tattccggca 5581 gtgggtatga tgaagaaatg agacggagga gcagggagct gaaaatcagg caaaagagcc 5641 actatagttt agaagaacta tcacgttggt taaacccaat agtgcaggga tggataagct 5701 attatggtca atattgtcgg tcggttctcg atcctgtatt tcgacatatc aataaaacgc 5761 tggtgcgttg ggcaagaagg aaattcaaga cgctaaagag gcacaaaagt agaacgatag 5821 gtctgtttga cagattatcg gtaaagtctt ccaaactatt cgctcactgg cgatttggct 5881 cagtaagaac gtttgcttaa tggaagcgga atgaattgag aggttcacgt tccattttgc 5941 gagaggctag aggggaagtt cctccggtct actcacctca cagctattta agagcttctt 6001 aacatattgg ggattaaaga aaaaattatc acaactgatg cgatggggtg ccagaaagat 6061 attgcagaga aggtacaaaa cagggaggtg attatttatt cgctgtaaaa gaaaatcagg 6121 ggcagcttaa taaagcctcg aggaaaagtt tcagctgaaa gacttgaatg atccaaagca 6181 tgacagttac gcaattagtg aaaagagtca cggcagagaa aaaatccgtc ttcacattgt 6241 ttgcgatgtc cctgatgaac ttattgattt cacgtttgaa tggaaaggac tgaaaaaatt 6301 atgcgtggca gtctcctttc ggtcaataat agcagaacaa aagaaagagc cagaaatggc 6361 ggtcggatat tatatcagtt ctcctgattt accgcagaga agttcgccac agcgattcga 6421 aattactggc accagaaagt gataatgagt gaagatgacc gcaaaataag aagaggaaac 6481 gaagcggaat tatttttagg gatacggcgc atctctatta atattttgac gaatgaaaag 6541 atattcaagg cagggctaag acgtaagaca cgaaaagcag tcatggacag aaactatcta 6601 gcgtcagtcc ttgtgggtaa cgggatttcg taatcttgtt ctgactgcta taaagacctt 6661 atgagttctt aaaaagcatt ttttgccaag agtaaattat tgactatcga ttggagagtg 6721 tatgtctatt ttggttactg gtgggtgtgg atatattgga atccacacga tttttactct 6781 gattacccaa ggtcatagtg ttgttgtatt agataactta actaactcat ctatagaacc 6841 attgaagaga gttgagttga tggcaaattg taatatacct ttctacaaag gaaatgttgg 6901 ggataaaagg ctattagtag aagtatttaa taagcatcag attactgctg taattcattt 6961 tgcaggattg aaatcagtaa gtgaatctat gaaaaaacca attgaatatt attctaacaa 7021 tgttacacaa acattatctc tgttagagtc gatgatagat aataatatca aaagttttat 7081 ctttagttcc tctgctactg tatatggtaa accaaatgaa tgtcctataa aagaatcaca 7141 taaaattggt aatacgacaa atccttatgg aacttcaaag tttataatgg aattaatgtt 7201 gtcagatttg tgtgaggcat ataatgatct aaatataact attttacgat attttaatcc 7261 aataggtgct catgagtcag gtaatatagg tgaacatcca aatggggttc caaataatct 7321 ttttccttat ctcatgaagg tagctatagg agagtatcca tatttaaatg tgtatggaaa 7381 tgattactca acatatgatg gttctggtat acgtgattat atccatgtcg tggatcttgc 7441 agaagctcat gccaaagcat tatcaaaaaa tttagtggta gatggtttaa aaatttataa 7501 cttaggaaca gggaaaggtt attctgtatt tgaagttata gaaacttttg aaaaaataac 7561 agggataaag attccatata gagttatgcc ccggagagat ggggacgtcg cagaatgttg 7621 gtcaaatagt ttgaaggcaa atgaagaatt agaatggaaa gcaacaaaag atttatctga 7681 tatggtaaga gatgcttgga attggcaatt gaaaaatcct catggttatg acaacgatga 7741 agtaatgctc ttagatagta aaatggatga tttgtaaatg cgatttaagt ttagtactat 7801 gaggtgtggg ggagagggga tgactgatgt tctttattag aaaaatttac ttatcagtgg 7861 tcagtttttc tgtataaaga gtttatacag agtgagtaat ttttgattgg tttatcgacg 7921 cggggtataa cagtataagt ttcgcgtcta tttatattcg gattatattc atactgaagc 7981 cagattttat agaggagtta ttgataaatt tctattgata gttgaatata taaatacaat 8041 gttgatatgg ggttatgttt attatatttg gatgagaagc aggggcattg taagtgaatc 8101 ttaggcaaga ataatataca gtatgatcat atcatcagct tgttgaaaaa tacatgattt 8161 atcagtacat aaaaatatat cttgtaactt ttattgatta aaatggaaag gcaaatttat 8221 aatatgctag ttaggtagtg aagacaattg aaacaagaaa cgttaaattt ataaagttta 8281 ttcgattatt aggatgcata atgaaaaaag taataacttt tggtacattt gatgtatttc 8341 acgttggaca tataaatatt ttagagcgag cgtctaaact cggagattat ttgatcgttg 8401 gagtatcttc cgacaaactt aactttagta aaaaaaatcg ttttccaatt tatagtgaga 8461 aggacagggt aaaaataatt tcatctttaa ggtttgttaa tgaggttttt attgaggaat 8521 cgttagaact taaactggag tatattaaaa aatataatgt agacctgctg gttatgggag 8581 atgactgggc tggaaaattc gattgggtta aatcaaactg tgaagttatt tatttgccta 8641 gaacaccatc tatttcaaca acagaaatta ttgagatagt aaggtctatt tgaaatgttt 8701 aggaggataa tttcacatag ggtgtttaag aattcatttg cattatttat catgcagtta 8761 ttttcatatg tttcaccatt attggttctt ccatatctgg ctaggatcat gtctgtagaa 8821 aactttggca tgctaatgat gctgtattct ttattagcca tatgccttgt cgtgactgat 8881 tttggtttta atttatcagg aacttactat atatcaagaa attataaaaa taaaaaaaag 8941 ataaatgagt ttttaacatc tgttttttgc attaaaataa tattatctac tgcatcagta 9001 atattttttc tggttttttt taggggggag tttcaacgtt tggataaata ctccgtgctt 9061 ttaattgcaa ttacaatgtt tgttcagtct tttcaaccta tatggttctt ccagggtata 9121 gaaaagatga ggcatataac tatatatacg gcactgtcaa aactgattta tcttttatta 9181 gtgtttttgt tcgttaccag cgattcaatt gtcacggtat tactatgcta ctgtataagt 9241 caaatggtag gaactttttt ttcaatttgt tttattttga aaatgaaata ttcgttttct 9301 cgaaccacat ataaaaatat aatttctgtt ttcagacaaa gtattccttt ttttgtgtca 9361 agagttgctg tggttgttta tacatctgca aatacacttt ttcttgggaa atatgggggt 9421 atggcgcagg ctgctagtta tagcagttgc gaaaaaatat attttgcagg gcaaagtttg 9481 ttaaacccgt tatcacaggc atttttccct tatttgtcta aaaatagaga tgcaaaattt 9541 tacattaaat ttgtaatatt gtcggtttgt attttgtcag ttatttgtgc agtggcatct 9601 ttttttgttt atgatttttt gaatattttt tatggccaaa aatacaatga ttcaattggc 9661 atattaaata catttctcat aacaactgtt attgcttata cgtcagtcag ttttggatat 9721 cctatgtata cccttattga taaaatagga tatgtaaatc acactgtaat tatcggagca 9781 gtgatacata tcataggact atttatatta gcaaaggaaa atatatttac agctcaaaat 9841 attgcttatt tagttttaat agtagaaaca tcagtgctaa ttacaagagt ttttctttat 9901 acatatctaa agattaagag ggtgtaatgg aattatttaa tttaatcaat tattcgctgt 9961 ataatagtat tattggtcga agttatagaa aaatccttag ggtatttgaa agaaataaaa 10021 acattaataa ggcacagtat ggggaaatgg ttgttaatga cgtgatgaaa ttgaactata 10081 attattttcc tatgtttggt acgttattat cgttgcatag agatgggagg tttgtatttg 10141 ccgatgattt cgattttgca attattggcg attttccaga ggatattatt tcaacctttg 10201 aaagaaatgg ttatcaatta tgcgctttat ctttgatagg aaacaaacgt gaaattattg 10261 agtattcttt tagtaaaaag ataaaaaatg aatatataaa ggttgatatc tttaaattaa 10321 aagaggtgaa taatattata cgacatagtt gtcctaattt tagaaaagaa aaggagtttg 10381 tgagatttcg agatggtctt aaaatatgcc agttcaatag ttattttact gttgattatc 10441 ctaagttcga tttaactgtc agcaaatggg ggataaaaat accaaataat cctgatgata 10501 tatttgaact tcattatggt catgattggg aaatacctaa aacatcaaac tttattgatt 10561 ttagtgcgta tcgctttatt gcagaaagat cggaaactgt actcggacca agtgagaaac 10621 ttaaagaata tattaaaaat aatatgagtt gttgatgatg attagattgc aaaatattat 10681 tttatttgta ttactagcat tttctggagt ttatgtatca tcttggttga ttaaacctag 10741 ttatgtcgca gttatcattt cattttttat cttaacgata ttaactttac gtggtgttag 10801 gtattcgttt tcatcatcta tttttatctt gatagcaatt tgcgtatttt atacaatatt 10861 taatcaattc gcccttgaag gagaattgcc aacaattatt ttttactcat gcctgatatt 10921 aattccattg cttgtatcaa catttaagag ttcaacatcc aaaagtaaca tacttctagt 10981 ttcatacata atattaataa tatattactc ttttgaaact ttcataagga ttactaaccc 11041 agattatagt catttgccta aaacaggtga tgatggtata acgtcaacat tctatattta 11101 taaaattaat agtattgctt ttgaagattc taactttatc agtgttattc ttgtggttta 11161 ttatatttca ttaaggagta cggctcttta tagcgatatt aaagttaaat atagtttggg 11221 actaaatatt ggtctgctaa ctttgatttt attaaccttc tcaagatctg catatatagg 11281 tgtgcttatt tttgaatgca tggttttatt cttttttaag cctgatgtta atatgaaatt 11341 acgtgggttg ttagtatcaa taatattggt aggtggtggt atatgtgctc atttcattat 11401 tgagaagatt gcttctgatc cgagttttat aagtaaattt tatattgttg atcttactgt 11461 aaagtattta agtcatgcgt caactttaga cattttattt ggtataggat tcggcaatgc 11521 tatcaatgtt cttggaatgg gagcgcataa tatattcata gcgattttca tagaaaatgg 11581 cttgatagga acattattat acttatacat attaattatg ctttcaatac ggtataagtt 11641 aactatgtta ttaattattc caattagtat catggggtta tctttttcgc aaatagcaat 11701 gccgtatttt tatgtagtta ttgcatggct gatttttgta aatgaggaca gatgtgaaaa 11761 aattagtaag tgttgtaatg cccacttata ataatgagaa atatattaag tctgcaatag 11821 atgatattat gaatcaaact tatcagtatt gggagttaat aataattaat gatggttcaa 11881 cagataacac ctgccaaatt ttatcagaat acaacaaggt taataatata catattatta 11941 accttgttgc taataaagga atttgtgaag cattaaatgt tggtttaaag attgctaagg 12001 gagattttat cctcaggttt gacgcagatg atagatgttc tagtgataga ataagtaaat 12061 tacttgaata catgttaaag aataatattg atatagtagg aagctctgta attactataa 12121 acgaaaatga tgatgtaatt ggtaaagccg tttttagtga taacgagagg attataagcc 12181 gtttaataag atatgaaaac cctatattac acatttggct ggcaaaaaga gaagtatatg 12241 ataaattagg agggtatagg ataggaggag tggaagacta tgattttatt ctacgagctc 12301 tagactctgg ttacaaggta tctaatatca gcgattattt tggtatttct attcgaaaac 12361 atagtagaaa tactgcgaat actcaaggat ggaggcaacg taaatgtttt aatttggctt 12421 ggacgttaca taaggaaagg ttgaaaaaag gttatgaagt tacaagcagc ataccaagat 12481 atggacgttt tatcaaatat ggtgataaaa tccacgccat atctaataaa ttattagtta 12541 aggggatttc ttcaaaaaaa ttatcctata agatagcgat aatagtagct gctgctgtta 12601 tttccccata tcagtttcaa tatttaattt atcgattcat tggcaagata ataaaaaaga 12661 ctctatgaaa atactttaca tcataccaag tttaaaaaaa tgtgggccag taaatgtttg 12721 cttatcattg gcaaaaaata tctcggaaaa tcatagtgtt tctatattgg cttttcgcaa 12781 tggaaattcc tttaatgatt tttattcttg ctgtgataat gttaagataa taccaattta 12841 taatcttttt gccatagcaa gatttattgc tgccgagaaa tttcagatta tccattcgca 12901 ttgtttggta cctgattttt tattatcttt gtttagcttc tttttcagga ataaatttat 12961 cccaatatcg acaatacata attatattga tattgattat attttcagta aaggactttt 13021 tataggtaag ttgatgggag tcattaatcg gctttcatta agtaaaatta agaacttagt 13081 ttcatgttct ttagctgtta aatattattg tgatgttgct tatgatataa gaagtactgc 13141 aattagtaac ggagttccta tttctccata tatagatgag atgcaacaag aatgcaataa 13201 aaaatttatt gatttttatt atgttggtgt tctgacagaa cgcaaaaatg ttgacttact 13261 catacagtca tttcatttat ataaaagaaa atataaaaat gaagaccgat tgcatgtgat 13321 tggcggaggg gagttgttgg aagttttaaa aaaaaataac aagtgcgatt atattatttt 13381 ttatggccct caagtaaatc catggcctat tattaaatct ttagacattt atgtgagtag 13441 ctctagagct gaagggatgc cgttggcatt attagaagcg ttatcaatag gaaaggcata 13501 tatttgttca aatattgaac cgcactgtga ggtccatcat gttgttaatg gtggtattat 13561 ttgctccttt gataaagatg attttgttaa agcttttcat catatgagat attgggatct 13621 aaaaccaaaa aatgagtata ttcttgagag gtttaagaat aattatgcag attatataat 13681 ggctgggaaa tatctgatta agtatgagga gttactcaag gaacatgaat gacataaggt 13741 tttctgtgtt aatgtctcta tataaaaatg agtctgaaaa attcttggat gattgttttt 13801 ctagcgtata tgatcagacg ttacctgcta atgagataac tctggtaatt gatggcccaa 13861 ttcccaattc acttgaatat gttgtgttaa aatggatggt ttttttacct ataaatgtgg 13921 ttagacttga aaaaaatgtt ggattgggcc aagcattaaa ctatggaatt aaagcttgtt 13981 caaatgatat tattataaga atggatactg atgatatttg taaaagaaac agatttgaag 14041 ttttagtaaa aaaattgaat tcaaataata ggttagctgt agtcggctct tgtatcgaag 14101 agtttgttca tcttccaagt aatattatct cagtaagaac tgttccacta gatcctgaat 14161 ccataaggaa agaaatctta gttagaaatc ctttcaatca tatgtctgtt gcattcagaa 14221 aaaaatttat tgaaagcgtt ggtggatatg tccatcatca ttttatggaa gattataatc 14281 tttggttacg agtagtggca tctggatttg atgtgtgtaa cattaatgag tcgttaatat 14341 tagctagagt tggtgataat atgttggcta ggcgaaaagg gctgaggtat ataaaaagtg 14401 aattccaact ttatcggcta aaagttaaac ttggtttgca gtcacatata tctggattct 14461 gcattttgtt agtaagaagc attccgcgat tactccctct aaaggtctta aaaattattt 14521 accaatatat tcggaagtaa ttatataata attctgaaga ttgcactctt attttttctt 14581 agttgtatct ttgtatgtta acattacgtt taaaccgaac cgctaagacg gtaatttcgt 14641 gacaggagta aacaatgtca aagcaacaga tcggcgtcgt cggtatggca gtgatggggc 14701 gcaaccttgc gctcaacatc gaaagccgtg gttataccgt ctctattttc aaccgttccc 14761 gtgaaaagac ggaagaagtg attgccgaaa atccaggcaa gaaactggtt ccttactata 14821 cggtcaaaga gtttgttgaa tctctggaaa cgcctcgtcg catcctgtta atggtgaaag 14881 caggtgcagg cacggatgct gctattgatt ccctcaagcc atacctcaat aaaggtgaca 14941 tcattattga tggtggtaat accttcttcc aggacaccat tcgtcgtaac cgtgagcttt 15001 ctgccgaagg ttttaacttc atcggtaccg gtgtttccgg cggtgaagag ggggcgctga 15061 aagggccttc catcatgcct ggtgggcaga aagaagccta tgaactggtt gcgccgatcc 15121 tgaccaaaat cgccgccgtt gctgaagatg gcgaaccgtg cgttacctat attggtaccg 15181 atggcgcagg tcactatgtg aagatggttc acaacggtat tgaatatggc gatatgcagc 15241 tgattgctga agcctattct ctgcttaaag gtggcctgaa cctcaccaac gaagaactgg 15301 cgcagacctt taccgagtgg aataacggtg aactgagtag ctacctgatc gacatcacca 15361 aagacatctt caccaaaaaa gatgaagacg gtaactacct ggttgatgtg attctggatg 15421 aagcagcaaa caaaggtacc ggtaaatgga ccagccagag cgcgctggat ctcggcgaac 15481 cgctgtcgct gattaccgag tctgtgtttg cacgttatat ctcttctctg aaagagcagc 15541 gtgttgccgc atctaaagtt ctctctggcc cgcaagcgca gccagctggc gacaaaggtg 15601 agttcatcga aaaagttcgt cgtgctctgt atctgggcaa aatcgtttct tacgctcagg 15661 gcttctctca gctgcgtgct gcgtctgaag agtacaactg ggatctgaac tacggcgaaa 15721 tcgcgaaaat tttccgtgct ggctgcatca tccgtgcgca gttcctgcag aaaatcaccg 15781 atgcttatgc cgaaaatccg cagatcgcta acctgctgct ggctccgtac ttcaagcaaa 15841 ttgccgatga ctaccagcag gcgctgcgtg atgtcgttgc ttatgcagta cagaacggta 15901 tcccggttcc gaccttcgcc gctgcggttg cctattacga tagctaccgt gccgctgttc 15961 tgcctgcgaa cctgatccag gcacagcgtg actatttcgg tgcacatact tataagcgca 16021 ttgataaaga aggtgtgttc catactgaat ggctggatta atctgattta accaacaata 16081 aaattgaggc ccggcgtata ttgcaccggg cttttttttg ccaattatct tatagactaa 16141 atttcactgc ttaatattaa cttaataaat atcagctatt cttataaaga aaatctgaat 16201 tgtttttcgt tgcgttgacc atctgacaac gtagcgttaa aacttttagc tctaatcagg 16261 atgctaaaaa catcatgatt cacagttaag ttaattctga gagcatgaaa tgaaaatcac 16321 catttccggt actggctatg taggcttgtc aaacgggctt ctaatcgcac aaaatcatga 16381 ggttgtggca ttagatattt taccgtcacg cgttgctatg ctgaatgatc ggatatctcc 16441 tattgttgat aaagaaattc agcagttttt gcaatcagat aaaatacact ttaatgccac 16501 attagataaa aatgaagcct accgggatgc tgattatgtc atcatcgcca ctccaaccga 16561 ctatgatcct aaaactaatt atttcaatac atccagtgta gaatcagtaa ttaaagacgt 16621 agttgagata aacccttatg cggttatggt catcaaatca acggttcccg ttggttttac 16681 cgcagcgatg cataaggaat atcgtactga aaatattatt ttctctccgg aatttctccg 16741 tgaaggtaaa gctctttacg ataatctcca tccttcacgt attgtcattg gtgagcgttc 16801 agaacgcgca gaacgttttg ctgctctgtt acaggaaggc gcgattaagc aaaatatccc 16861 gaccctgttc accgattcaa ccgaagcaga agcgattaaa ctgtttgcta atacctatct 16921 ggcgatgcgc gtagcatact ttaatgaact ggatagctat gcagaaagtt taggtctgaa 16981 tactcgtcag attatcgaag gtgtttgtct cgatccgcgt attggcaacc attacaacaa 17041 tccgtcgttt ggttatggtg gctattgttt gccgaaagat accaagcagt tactggcgaa 17101 ctaccagtct gtgccgaata acctgatctc ggcaattgtc gatgcaaacc gcacgcgtaa 17161 agattttatt gccgatgcca ttttgtcacg caaaccgcaa gtggtgggta tttatcgtct 17221 gattatgaag agcggttcag ataacttccg tgcgtcttcc attcagggaa ttatgaaacg 17281 tatcaaggcg aaaggtgttg aagtaatcat ctacgagccg gtgatgaaag aagacacatt 17341 cttcaactct cgtctggaac gcgatctcgc caccttcaaa caacaagccg acgtcattat 17401 ttccaaccga atggcagaag agcttaagga tgtggcagat aaagtctaca cccgcgatct 17461 ctttggtagc gactaacatc ttgttatcag ggcgattttc gccctgattc tcttatgttc 17521 cctttgtaat aattcattat ttttatcatt tatcctatag cattcatggc gattatcgct 17581 aaactatggc gacttaaaat tatttcgtcc gttagggtaa tgatgagagt agaaaataat 17641 aatgtttctg ggcaaaacca tgacccggaa cagattgatt tgattgattt actggtccaa 17701 ctatggcgcg gcaagatgac tatcatcatt tctgtcattg tggctattgc cctggctata 17761 gggtatctgg ccgttgccaa agaaaagtgg acttccacag ctatcgttac tcaacctgat 17821 gtggggcaaa tcgctggtta taccaacgcg atgaatgtga tctacggatc agctgtaccg 17881 aaagtctccg acattcaggc ttcacttatc ggacgttaca gcactgcatt ctcagcatta 17941 gcggaaacgc tggataacca ggaagaagca gaaaagctga ccattgagcc taccgttaaa 18001 aatcagtcat taccgttagc ggtttcttat gtgggtgaaa cacctgaagg tgcgcagaaa 18061 cagctggcga agtatatcca gcaagttgac gaccaggtca atgaagaact ggaaaaagac 18121 ctgaaagata acatcgcgct gcgtatgaaa aacttgcagg actctctgaa aacccaggaa 18181 gtggtcgcgc aggagcagaa agatctgcgt atccgtcaga ttcaggaagc gttgcagtat 18241 gcgaatcagg cgcaggtgac aaagccacaa gttcagcaga ctgaagatgt gacacaagat 18301 acgttgttcc ttttggggag cgaagcgctg gagtcgatga ttaagcatga ggcgacccgt 18361 ccgttggtgt tctcgccaaa ctactatcag actcgtcaaa acctgctgga tatcgaaagc 18421 ttaaaggttg atgatcttga tattcatgct taccgttatg tgatgaaacc gatgttacct 18481 attcgtcgcg atagcccgaa aaaggcaatt accttgattc tggcggtgct gctgggcggc 18541 atggttggcg cggggattgt gctggggcgt aatgcgctgc gtaattacaa cgcgaaataa 18601 tctttgcagc tttaaagaaa acgggcaggg tggtgacacc ttgcccgttt tttttgccgg 18661 atgcgatgta tccagcttac gtgtgcagag agaatagtcg gcccgataag cttgcgcatc 18721 gggctatggc tccggatgcg acaacaacat cgcatccgct tacccagtaa ctcactgatg 18781 ccgtttacgc aggttctcaa ttaccgtcgt taaatccaga tcctgatcct gcaacagcac 18841 cagcaggtga tacatcaaat cagatgcctc gttggtcagc tcaaagcggt catgtaccgt 18901 tgctgccagt gcggtttcca cgccttcttc gcccactttc tgcgcaatgc gtttggtgcc 18961 gctggcatac agtttggcag tgtaggaggt ttccgggtcg gcagatttac gttcggcgag 19021 cagttgttcc agttgataca ggaacagcca ctggtgagcg gtgtcgccga agcagctgct 19081 ggtgcctttg tggmaggttg gccc //