LOCUS FJ940773 17685 bp DNA linear BCT 13-SEP-2009 DEFINITION Escherichia coli serogroup O99 O-antigen gene cluster, complete sequence. ACCESSION FJ940773 VERSION FJ940773.1 KEYWORDS . SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 (bases 1 to 17685) AUTHORS Perepelov,A.V., Li,D., Liu,B., Senchenkova,S.N., Guo,D., Shevelev,S.D., Shashkov,A.S., Guo,X., Feng,L., Knirel,Y.A. and Wang,L. TITLE Structural and genetic characterization of Escherichia coli O99 antigen JOURNAL FEMS Immunol. Med. Microbiol. 57 (1), 80-87 (2009) PUBMED 19682076 REFERENCE 2 (bases 1 to 17685) AUTHORS Perepelov,A.V., Li,D., Liu,B., Senchenkova,S.N., Guo,D., Shevelev,S.D., Shashkov,A.S., Guo,X., Feng,L., Knirel,Y.A. and Wang,L. TITLE Direct Submission JOURNAL Submitted (17-APR-2009) TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, Tianjin 300457, P. R. China FEATURES Location/Qualifiers source 1..17685 /organism="Escherichia coli" /mol_type="genomic DNA" /strain="G1251" /db_xref="taxon:562" /note="serogroup: O99" misc_feature 1..17685 /note="O-antigen gene cluster" gene 108..1523 /gene="manC" CDS 108..1523 /gene="manC" /note="GDP-mannose pyrophosphorylase" /codon_start=1 /transl_table=11 /product="STP|AraC_binding" /protein_id="ACV53833.1" /translation="MLLPVIMAGGTGSRLWPMSRELYPKQFLRLYGQRSMLQETVLRLD DVDAREPVVICNQEHRFLVAEQLRQINKLSHNIILEPVGRNTAPAIALAALSAIENGDD PILLVLAADHIINNKLAFHQAIKSAFKFALQGRLVTFGIVPTGPETGYGYIHRGQEETL DEQIAYQVSRFVEKPNKETAESYIASGEYYWNSGMFMFRAKKYLEELEKFRPDILDACK AAIQGCKESDEFIKVDRDLFIACPDESVDYAVMEKTTDAVVVGLDADWSDVGSWSALWE VSPKDDKGNVLTGDTFLHNANNCYINTDEKLIAAIGVDDLVIINTKDAVLVVNKDQVQD VKKVVEYLKANHRSEYKRHREIYRPWGRCDVVVQTERFNVNRITVKPGAAFSMQMHHHR TEHWVILSGTGEVTIKDQKFLLTEDQSTFIPIGAQHRLENPGKIPLELLEIQSGSYLGD DDIIRIKDQYGRC" gene 1543..2916 /gene="manB" CDS 1543..2916 /gene="manB" /note="phosphomannomutase" /codon_start=1 /transl_table=11 /product="ManB" /protein_id="ACV53834.1" /translation="MSQLTCFKAYDIRGKLGKELNEDIAYRIGRAYGEFLKPKTIVVGG DVRLTSESLKLALANGLMDAGTDVLDIGLSGTEEIYFATFHLGVDGGIEVTASHNPMDY NGMKLVRENAKPISGDTGLRDVQRLAEANDFAPVDQSRRGSYKQISVLDAYVDHLMGYI DFANFNRPLKLVVNSGNGAAGHVIDAIEKRFNDAKVPVTFIKVHHQPDGNFPNGIPNPL LPECRQDTTDAVIANQADLGIAFDGDFDRCFLFDGQGQFIEGYYIVGLLAEAFLQKEPG AKIIHDPRLTWNTIDIVTKAGGVPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFA YCDSGMIPWLLVAEMLCVKNQSLGELVGQRMQAFPASGEINRKLGNAQVVIQRIRDIYE PDAVSIDGTDGVSIEYSDWRFNLRTSNTEPVVRLNVESKADTNLMQIKTEDILNLLSE" gene 2920..3714 /gene="wzm" CDS 2920..3714 /gene="wzm" /note="integral membrane component of ABC-transporter" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q9HTB8|3.A.1.103.6" /protein_id="ACV53835.1" /translation="MKSLLLAIFRYRGFIVDSIKRDFQSRYQASFLGAAWLVLQPIAMI SVYTLIFSELMKAKFSGVSGQYAYSIYLCSGVLTWGLFSETLNNLVNVFISNANVLKKI NFPKICLPIIVSVSAFLNFLIIFTLFVIFLILTHNFPGWIILAIIPVLIIQMIFTVGLG VLLGVVNVFVRDVGQFVIILTQFWFWFTPIVYVRNILPDWSRGLIDLNPMAVLIEAYQK IILFQQQPDWYKLLPVAIIAIIIFMFSWSLFRKHAADIVDEI" gene 3716..5017 /gene="wzt" CDS 3716..5017 /gene="wzt" /note="ATP binding component of ABC-transporter" /codon_start=1 /transl_table=11 /product="gnl|TC-DB|Q9I3V8|3.A.1.103.6" /protein_id="ACV53836.1" /translation="MSIYVKNVGKAYKYYDSKWKRIFEKLTPGKAILHSKKWVLRNISF TINPGESVGIVGVNGAGKSTLLKLLTGTTQPTEGTIQICGRVAALLELGMGFHPDFTGR QNVYMSGLMMGLSREQISHLMPEIESFADIGNYIDQPVRIYSSGMQMRLAFSVATAYRP DILIVDEALSVGDSRFQAKCFSRIAEFKKAGTTLLLVSHSASDIVRHCDRAIFLKNGSI ELDGSSRDVTNRYMDELFGKTNSLSEYKKNSTEPKNSMALFKDADPTETKEFYHTRPGY RPEEYRWGQGGARIIDYTIQVNGKHYPSNIESNQLTDFYIKVFFEQSYDNIVPGILIKT LDGIFLYGTNSFLASEGKDEIGVKSGDIKIFKFSFPLDLNSGDYMLSFGVSAGNPQSEM IPLDRRYDSVILHVRKKMEFWGIIDLKSSFSCCN" gene 5039..7219 /gene="wejH" CDS 5039..7219 /gene="wejH" /codon_start=1 /transl_table=11 /product="STP|Pkinase" /protein_id="ACV53837.1" /translation="MNANLESLISDLPEIYQTIFGHEKWNDASSRDCSIRLAIITEQYQ KLEKSLQRPLRVLDLGCAQGFFSLSLAKLGATVRGIDFLPANILVCQALADENPDLDVT FEVGRIEEVIKSLTENDYDMVIGLSVFHHIVHEHGLAQVKQWIKRLADCTVILIMELAL REEPLYWGASLPENPAELIDLCAFYRQIGEFETHLSHINRPMYLISNKIVILDSFISAF DSWRNTPHSATDGHPHEGARRYYFGESFVCKFFTFQQIGNKDTYQSQRNREELTREVQF LNDPPEGFNVPTLIESKTSKYDSWLVMERIHGELVSSLLDKKQAINIDNLLTDLLSQLV VLEKAGLYHDDIRLWNIIYDQDNKCFSLIDYGSISSVKQDCGWPFNIFLSFFVFVNELL SKVSDKKVIWRKGYINPFLLPEPYNHWLSALWQESADNWSFSLIKQLFEEKNNLPANYT KFSGMENWIVAQEKLSFFLQDEEITNRKSIVHLNNVVASLTTMLNNIQITLNDQIKINE SSLLKLQQDVESGKVGNEGMASELKLLTDKVCKLDIGTNEINSTAENSRLEIDKSFADI AQLNAKVDGLVETIRHLEADNIKTNAQNQAILNSRSWMITKPYRYFGLQIKLLRQYGFK QRIKHLVKRIIIILTAFLQRHPSYKNKVVTVLHKTGLYRIAYKYYRRVFPHVVYQSTEQ DINDAKIDTQLRSLDAVPDEVKEIYKMITKDK" gene 7230..9725 /gene="wejI" CDS 7230..9725 /gene="wejI" /note="glycosyltransferase" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="ACV53838.1" /translation="MHILIDIQGLQSESKVRGIGRYTLELTRAIINNCGQHRISLLLNG LYPIGNINDAKAKFHGLVHEKDCYVFSAVGPIEYRNINNIPRNKASRQCREAAIAEIAP DIVLISTFFEGYTDDFIVSISENVSWKTFVICYDLIPLLNKERYLCDPLFEKFYMNKVS ELRKVDGLLAISESSRQEFISHANIDENKIINISSAASDDFRQIELSEYIIQDITQRFQ LPEKFILSLAMIESRKNIETLIVSYGKLSEELQNEYPLVLAYKVNPEDKKRIIELAQDN GVNINSLVFTGYLNDQDLIVLYNLCALFVFPSLHEGFGLPPLEAMKCGAATIASGTTSL PEVIGWDGAMFDPRNPDAICTLICKALTDEEYYSALKENARIQAQKFSWNISAERAIAA MEKLLDSQSQSTNRTDIHNNIVNISEITELTPNEQLRAAWAIARNNFTQHKRKILVDIS VLVHHDAKTGIQRVSRSILTQLRKIDLHGYEVYPVYYTHGEYYRYANRFTADNFDSGLK SDNPVLFTKDDILLVADLTAHLFPDIIPEINYIRKAGAKAVFIVYDILPILHPEWCAES IRQAFPLWLKGLVSCADQLICISESVANEVRNWIDAQETDVNPYLMVDSFHLGADFEGS LPSKGMPETATAFLAGMSSVPTFLMVGTLEPRKGHSQTLAAFKQLWSEGYDFQLCIVGK QGWNVESLISEIENSDELNNKLFWLQNISDEYLDAIYANACALIFASNGEGFGLPLIEA AQKNIPLIIRDIPVFKEIAESNAFYFHGQKPDDLKNAIIEWHKLYTNHTHPTSAGIKWQ TWRQSVEQLLNKLPITKEC" gene 9857..10891 /gene="gmd" CDS 9857..10891 /gene="gmd" /note="GDP-mannose 4,6 dehydratase" /codon_start=1 /transl_table=11 /product="Gmd" /protein_id="ACV53839.1" /translation="MKSAIITGITGQDGAYLAELLLGKGYKVYGTYRRTSSVNFWRIEE LGIKNNPNLHLVEYDLTDLSASIRLMQTTNATEVYNLAAQSFVGVSFDQPVTTAEITGL GAVNLLEAIRIVNPQIRYYQASTSEMFGLVQAVPQKEDTPFYPRSPYGVAKLYAHWMTV NYRESYNIFASSGILFNHESPLRGQEFVTRKITDSVAKIKLGKQDVLELGNMDAKRDWG YAKEYVEGMWRMLQADKPDTFVLATNRTETVRDFVSMAFKAAGFTLRFEGKDENEVGID VATGKTLVRVNPKFYRPAEVDLLIGNPARAKEILGWEPKTTLEQLCQMMVEADLRRNQQ GMTF" gene 10891..11793 /gene="rmd" CDS 10891..11793 /gene="rmd" /note="oxidoreductase" /codon_start=1 /transl_table=11 /product="Rmd" /protein_id="ACV53840.1" /translation="MTDAGKHALITGINGFTGRYVAAELSAAGYRVFGLGAGSVPYDGP DYYQVDLMDVTALTNVVTSIKPNVVVHLAAIAFVGHGDADAFYNINLLGTRNLLQALSH CDNSLDAVLLASSANVYGNGTAGKLSETTAPNPANDYAVSKLAMEYMARLWMDKLPVFI TRPFNYTGVGQADNFLLPKIVKHFKAKAPVIELGNIDVWRDFTDVRALSQAYVKLLQAK PTGEVINICSGRTYSLRKIIELCEKITGHHLEIQVNQAFVRANEVKTLSGDTTKLQSFI PEWDVPPLEDTLRWMLESD" gene 11793..12929 /gene="wejJ" CDS 11793..12929 /gene="wejJ" /note="glycosyltransferase" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="ACV53841.1" /translation="MKVIFGTDAIKFPLTGIGRYAFELANHLAGSPEISELLYLRGKTL STHIPIAKEAHSSAEGIKHFLKKNRLASEFYRITAPWFKTNVLRKHKDAIYHGPNFYLP PKVGRCVVTFHDLSVFTLPQCHPPERVRYMRKELLQTVRRAEIFLTDSDFTRSELINYF NLPESQVYTAKLACSRDYRPYSYFEATETLRKYNLSFKNYTLFIGSIEPRKNISTLLTA YNRLPLSLRQRVPLVISGFKGWNSDDLHKRFMKGEREGWLRYLGFTPYADLPALYAGAT TFIFPSIYEGFGLPVLEAMASGTPVVCSNSSSLPEVVGDVALMCDALDVETLTTLIIKS LEDDPWRLWAGEHGIQRASQFSWERCASETITAYKQVI" gene 12935..14047 /gene="wejK" CDS 12935..14047 /gene="wejK" /note="glycosyltransferase" /codon_start=1 /transl_table=11 /product="GT4" /protein_id="ACV53842.1" /translation="MLKVLHFYKTYYPDTFGGIEQVIYQLSESGLNFGVESTVLSLSKR GDYDNEKFGSHRVYYAKTNFEIASTPFSVSSISKFRKLAKEADIIHYHFPFPFMDMLHF IDGINKPSIVSYHSDIVKQKSFLRLYSPLMNHFLAAVDYIVTASPNYAQTSPVLQKFKN KVKVIPYGLNESSYSLIPAEKLEYWRQKVGDKFFLFIGAFRYYKGLHTLLDAAYTTSLP IVIVGSGGIEKEIRLRANQLNLSNVHFVGALPEDDKAALLQLCYAVVFPSHQRSEAFGI TLLEGAMYGKPLISCEIGTGTSFINIDGQTGLVVPPSNSYALREAMLKLWDSPLLAEIY GQNAFYRFKELFTSNNMCKKYVELYTRLVS" gene 14094..15254 /gene="wejL" CDS 14094..15254 /gene="wejL" /codon_start=1 /transl_table=11 /product="WejL" /protein_id="ACV53843.1" /translation="MNIKHVREYYNFEYAIPFFVGMIFFGVAFNYDIISPSNISWLVGD RLQSYLGWEYFRHAPWQFPVVGRTNYGMELSSSIVFTDSNPWLSILLKPFSSFLPSTFQ FGGAWLLLCVIAQAIILWKIISIYTQNNCIKTIALVFMLFNPAWINRTGHLMLMSFFIF TAGIYLSLKYSKTTSFNNAKWLLLLCIAIGTHFYIYLLIFINWFVIVFYAFLCEPANRK KIILSFFLNILVSFSLFYVFGYLTIGGGASAGGFGFYKANLLFPILAGGNSEIIGLNFF HPGEYEGYNYFGGGLILLIIINIFFGKVDLFSVVKNNVPLFLFSLICFVLAISNVIAIG DNEFTIPLPNILLNILSNFRASGRFLWPVVMLIFFIFLFAYNEISW" gene 15238..16155 /gene="wejM" CDS 15238..16155 /gene="wejM" /codon_start=1 /transl_table=11 /product="WejM" /protein_id="ACV53844.1" /translation="MKFPGKWPWLILLICTSLQIYDISKSWLHNHNSLISNAVNNSTRF EEYSMLWNKHLSVYKNIRWFPTQNSGPKWSEISYLSNKYNQNTDAIYYARVDEKKLSAT MKKVSLQLLFGNYEFNTAYLMDKDYSSLIKLKKGDAIYKYKDLYILMPGNNSCDDCDIV NTSNVQQRDFDFSIGGIGRILLGDGWYSPEAWGVWSQGDVSEIFIPGDTKNVEIYFDGF LVPGKREHFNVSFYCGQEKISQLDVTPKSTREVLLNVSGCIKNEDNAIKLTVRNDNPGI PKMLFPNNEDSRLIAFGLKKIIMH" ORIGIN 1 attggtagct gtaagccaag ggcggtagcg tgctcaactt ccagagagca cttctcaaat 61 caactcacta tttttagcat aaagcgttga tattttaagg acttataatg ttacttcctg 121 tgattatggc cggtggtacc ggtagtcgtt tatggccgat gtcgcgcgag ttatatccaa 181 agcaatttct gcgtctctat gggcagcgct caatgctgca ggagactgtg ctgcgtcttg 241 atgatgttga cgcacgggaa cccgttgtga tttgtaatca ggagcaccgc ttcctggtag 301 ctgaacaact aagacaaatt aataagcttt cccataacat catccttgag ccagtggggc 361 gcaacacggc acctgcgatt gctttagcgg cgcttagtgc aattgaaaat ggcgatgatc 421 ctatactgct tgtacttgcg gccgatcata ttatcaacaa taagctggcg ttccatcagg 481 cgataaaatc agcattcaaa tttgccctgc agggaagact ggtgacattt ggtattgtgc 541 ctaccggtcc ggaaacggga tatggttata ttcaccgtgg gcaggaagaa acgcttgatg 601 agcagatcgc gtatcaggtt agccgattcg tagaaaaacc gaataaagaa acagcggagt 661 cttatattgc ctccggtgaa tattactgga acagcggaat gttcatgttc cgggcgaaaa 721 aatatctcga agagctggaa aaattcagac ccgatattct cgacgcctgt aaagcggcta 781 ttcagggttg caaagaaagc gacgaattta tcaaagtcga tcgcgatctg tttattgcgt 841 gtccggatga gtcggtcgat tacgcggtga tggaaaaaac cactgatgca gtcgtcgtcg 901 gccttgatgc agactggagt gatgtgggct cctggtccgc cctttgggaa gttagcccga 961 aagatgacaa aggcaatgtg ctcaccggcg acaccttcct gcataacgcc aacaattgct 1021 atatcaatac ggatgaaaaa cttatcgcgg cgattggtgt tgatgatctg gtgattatta 1081 atactaaaga tgctgtgctg gtggtgaata aagaccaggt tcaggatgtt aagaaagtcg 1141 ttgaatatct gaaagcaaat caccgcagcg aatacaaacg ccaccgcgag atttaccgtc 1201 cgtggggccg gtgtgatgtg gttgtccaaa ccgaacgctt taacgtcaat cgcattacgg 1261 ttaaaccggg cgctgcgttt tcaatgcaga tgcatcatca ccgtacagaa cactgggtta 1321 ttctctccgg gacaggtgag gtaactatta aagatcagaa attcctgtta acggaagatc 1381 aatcgacctt tatcccaata ggcgctcaac accgactgga aaaccctggc aaaatcccat 1441 tggaattgct tgaaatccag tcaggttcct atttagggga cgatgacatt atccgtatta 1501 aggaccaata tggccgttgc taacagtaaa ggtataagat ttatgtcaca actgacctgc 1561 tttaaagcct atgatattcg tggaaaatta ggcaaagaat taaatgaaga tattgcctat 1621 cgtattggtc gcgcttatgg ggaatttctt aaaccaaaaa caattgttgt gggtggcgat 1681 gtccgtttaa ccagcgagag tctgaaactg gcactggcaa atggcctgat ggatgcgggt 1741 actgatgtac tggatattgg gctaagcggc acggaagaga tctattttgc cactttccac 1801 ctgggcgtag atggtggtat tgaagtaacc gcgagccata acccgatgga ttacaacggg 1861 atgaagctgg ttcgtgaaaa tgccaaaccg attagtggtg acacagggtt gcgcgatgta 1921 cagcgtctgg ctgaagccaa tgattttgcg cctgtcgatc aatcccgtcg cggaagttat 1981 aagcaaatct ctgtattaga cgcttatgtt gatcatctga tgggctatat cgattttgct 2041 aacttcaacc gcccgttaaa gctggttgtc aattcaggta atggtgccgc aggtcatgtc 2101 attgacgcta tcgaaaagcg ctttaacgac gcgaaagtgc cggtaacttt tatcaaggta 2161 catcaccaac cggatggcaa tttccccaat ggtattccta atccactgct gccagagtgc 2221 cgccaggata ccacggatgc agtaattgca aatcaggcag atctgggtat tgcatttgac 2281 ggcgactttg accgttgttt cctgttcgat ggacagggcc agtttattga aggttattat 2341 attgttggcc tgctggcgga agcattctta cagaaagaac cgggtgcaaa aatcattcac 2401 gacccgcgtc tgacctggaa cacaattgat attgtgacta aagccggtgg tgttccggtt 2461 atgtcgaaaa caggtcatgc atttatcaaa gaacgtatgc gtaaagaaga cgctatctat 2521 ggcggtgaaa tgagtgcaca ccactatttc cgcgattttg cttattgcga tagcgggatg 2581 attccgtggt tattagttgc tgaaatgctg tgtgtgaaaa atcaatcgct gggcgaactt 2641 gttggtcaac gaatgcaggc tttccctgca tcaggtgaga ttaaccgcaa gcttggaaat 2701 gctcaggtag tgattcagcg tattcgtgat atctatgaac ctgatgcagt atcaattgat 2761 ggtactgatg gtgtaagtat tgaatatagc gattggcggt ttaacttgcg tacatctaat 2821 actgaaccag ttgtcagatt gaatgtggaa tcgaaagcag acaccaatct gatgcaaata 2881 aagacggaag atattttaaa tttgttaagt gagtaatttg tgaagtcact attattagcc 2941 atttttcgat atcgcggctt tattgttgac agtattaagc gggattttca gtcccgttac 3001 caggctagtt ttttaggcgc tgcctggtta gtacttcaac caattgccat gatatctgta 3061 tatacgctga ttttttcaga actcatgaaa gcgaaattct ccggagtcag tggtcaatat 3121 gcttatagta tatatctctg ttccggtgtt ttgacatggg ggcttttttc agaaactctt 3181 aataacttgg ttaatgtttt tattagtaat gccaatgttt taaaaaaaat aaattttccc 3241 aaaatatgtt tgccaataat tgtctcggtt tcagcttttc ttaatttttt aattattttt 3301 acgctatttg ttatttttct gattttaacc cacaacttcc ccggatggat tatattagcg 3361 ataattcctg ttttgatcat acaaatgatc tttactgttg ggttaggtgt attgctgggc 3421 gtagtgaatg tatttgttcg tgatgtaggg caatttgtaa tcatactaac gcaattttgg 3481 ttctggttta cccctatagt atacgtaagg aacattctgc ctgattggtc caggggatta 3541 atcgatttga acccaatggc tgttttgatc gaagcatatc agaaaatcat tctcttccag 3601 cagcaacctg attggtataa gttactccct gttgcaatta tcgcaataat aatattcatg 3661 ttttcatggt ctttatttag aaaacatgct gccgatattg ttgatgagat ttgatatgag 3721 tatttatgta aaaaacgtcg gaaaagcata taaatattat gattcaaaat ggaaacgaat 3781 ttttgaaaaa ttgactccag gtaaagcaat tttacactct aagaaatggg tattaaggaa 3841 tatttctttc acaattaacc caggagaatc tgttggcatt gtaggggtta atggcgcggg 3901 taaaagcacg ttgcttaagt tgttaactgg gacgacgcaa ccaacagaag gtactatcca 3961 gatatgtggt cgtgtagccg cattattaga attaggtatg ggcttccacc cggattttac 4021 tgggcggcag aatgtctaca tgtctggact aatgatgggt ctatctcggg aacagatttc 4081 acatttaatg ccagagatag aatcatttgc cgatatcggc aactacattg atcagcctgt 4141 acgtatctac tctagtggta tgcaaatgcg actcgctttt tctgtagcta ctgcgtaccg 4201 ccccgacatt cttattgtcg atgaggcgtt gtcagtaggt gattctaggt ttcaggcaaa 4261 atgctttagt agaatagcag aattcaagaa agcgggtaca accctgttgc tcgtctctca 4321 tagtgcaagt gatattgtcc gccattgtga cagagctata tttctcaaaa atggtagcat 4381 tgaacttgac ggatcatcac gagacgtcac caataggtat atggatgagt tatttggtaa 4441 gacaaatagt ttatcagaat ataaaaaaaa ttcgactgag ccaaagaata gcatggctct 4501 atttaaagat gctgatccaa ctgaaacaaa agaattttat catacgcggc caggttacag 4561 gcctgaagaa taccggtggg ggcaaggtgg tgcgcgtatt atcgactata cgattcaggt 4621 aaatggcaag cattatcctt ctaatataga aagcaatcaa cttactgatt tttatattaa 4681 ggttttcttt gaacaatctt acgataatat cgttcccggc attcttataa aaacacttga 4741 tggtattttc ctctacggta caaattcttt ccttgcatca gaagggaagg atgaaattgg 4801 cgttaaaagt ggagatatta aaatatttaa atttagtttc ccgcttgatt tgaatagtgg 4861 ggactatatg ctttcttttg gtgtttctgc aggtaatccg caaagtgaaa tgatcccttt 4921 agatcgccgc tatgattcag tcatattaca tgtacgtaaa aaaatggagt tctggggaat 4981 tattgatttg aaatcttcat tttcttgttg taattaaact tgggatgcgc ttagaaatat 5041 gaatgctaat ttagagtctt taatatctga cttgccagaa atttatcaaa caatttttgg 5101 acatgaaaaa tggaacgacg catcttcacg tgattgcagc atccgacttg caataataac 5161 agaacaatat caaaaactag agaagtcact tcaaagacca ttgcgtgttc tcgatttagg 5221 ttgcgctcaa ggctttttta gtttgagcct ggcaaaatta ggagcaactg tcagaggcat 5281 cgatttttta cctgctaata tccttgtttg ccaggccctg gcggatgaaa accctgatct 5341 ggatgttact ttcgaagttg gtcgaataga agaagttata aagtcattaa cagaaaatga 5401 ttatgatatg gtgataggcc ttagtgtttt ccaccatatc gtccatgaac acggtcttgc 5461 gcaggttaaa caatggatta agcgtctcgc tgattgtaca gttattctca tcatggaact 5521 ggctcttcgt gaagagcctc tatactgggg ggcttcttta cctgaaaacc ccgcagagct 5581 cattgattta tgtgctttct atcgacaaat tggcgagttt gaaactcact tgtcgcatat 5641 taatcgccca atgtacctta tcagtaataa aatagtcata ttggattcgt ttattagcgc 5701 atttgattca tggcgaaata cacctcattc agcgactgat ggacatcctc atgaaggggc 5761 cagacgttat tattttggtg aatcttttgt ttgtaagttt tttaccttcc aacaaatagg 5821 gaataaagat acatatcaaa gtcagcggaa tagagaagaa ctgactcgtg aagttcaatt 5881 cttaaatgat ccccctgaag gatttaatgt tccaacgctt atagaaagta aaacgagtaa 5941 atatgatagt tggctcgtta tggaacgtat ccatggcgag ttggttagtt ctttactgga 6001 taaaaagcaa gctatcaaca ttgataactt attaacagat ctgctgtctc aattagttgt 6061 tcttgaaaaa gctgggcttt atcacgatga tattaggctt tggaatatta tatatgatca 6121 agataacaag tgcttctctt taattgatta tggttctata tcaagtgtaa agcaagattg 6181 cggctggcct tttaatattt ttctatcttt ttttgtattt gttaatgaat tgttatcaaa 6241 agtttctgac aagaaggtta tttggagaaa gggttatata aacccattcc ttcttccaga 6301 accatataac cactggctaa gcgctttgtg gcaggagtca gcggataact ggagcttttc 6361 tttaattaaa cagctttttg aagaaaagaa taatcttcca gctaattata caaaattttc 6421 agggatggag aattggattg tggcccaaga aaaattatca ttttttcttc aggatgaaga 6481 aattacgaat agaaaaagca tagtccatct taataatgta gttgcttcat taactactat 6541 gctaaataat attcaaatta cattaaatga tcagattaag ataaacgaga gtagtttact 6601 aaaactacag caagatgttg agagtggcaa agttggtaat gagggaatgg cttcggaact 6661 gaaattatta actgataaag tctgtaaatt agatattgga actaatgaaa taaactctac 6721 agccgaaaac tctcgtttag aaatagataa gtcttttgca gatatagcac aactgaatgc 6781 taaggttgat gggcttgtag agacaatacg tcatttagaa gctgataata taaaaacaaa 6841 tgctcaaaat caagcaatat taaatagccg ctcctggatg attacgaaac catatcggta 6901 tttcggtttg caaattaaac tgttaaggca atatggattt aagcaaagga taaaacatct 6961 tgtaaaaaga attattatta tactaacagc ctttttacag agacatcctt cttataaaaa 7021 taaagtggtt actgttcttc ataaaactgg gttgtacagg attgcatata agtattaccg 7081 gcgtgtattt ccacatgttg tttatcaaag tacagagcaa gacattaacg atgctaagat 7141 tgatactcaa ctgagaagct tagacgctgt acctgacgaa gtaaaagaaa tttataaaat 7201 gataacaaaa gataagtaag gggcaagaaa tgcatatttt aattgatatt caggggttgc 7261 aatccgaaag taaagtacgt ggtattggta gatacacgct tgagttaact agagcaatta 7321 ttaataactg tggacaacat cggattagcc ttttgcttaa tggattatat cctatcggta 7381 atattaatga tgccaaagca aaatttcacg gtttagttca tgaaaaagat tgctatgttt 7441 tttctgccgt tgggcctatt gaataccgta acataaataa tattccaaga aataaagctt 7501 caagacagtg cagagaggct gcaattgcag agattgcacc agatatagtt ttaattagca 7561 catttttcga aggatatacg gacgatttta ttgtttctat ttccgaaaat gtgagttgga 7621 aaacatttgt aatttgctat gatttaattc ctcttcttaa caaagagcgc tatctttgcg 7681 atcctttgtt tgaaaagttt tatatgaata aggtctcaga gcttagaaag gtagatggtc 7741 ttttggcaat ctcagagtca tcaagacagg aatttatatc ccatgcaaat attgatgaaa 7801 ataaaatcat caatatatct tctgctgcta gtgatgattt tagacaaata gaattatcag 7861 aatacataat acaggatata acccagcgct ttcaattgcc agaaaaattt attctatcgt 7921 tagcgatgat tgaatcgcga aaaaatattg aaacattgat cgtttcatat ggcaaacttt 7981 ccgaagaatt gcaaaatgaa tatccacttg tacttgctta taaagtaaac ccagaagata 8041 aaaaaagaat aatagaactt gctcaggata atggtgtaaa tattaactct ttggtattta 8101 ctggttattt aaatgaccaa gatcttatcg ttctttacaa cctttgtgca ttatttgttt 8161 ttccttcact tcatgaaggt ttcggtttac ctccccttga agcaatgaag tgtggtgccg 8221 ctacgattgc atcaggcacg acaagtttac cggaagttat tggttgggat ggcgctatgt 8281 ttgatcccag aaatccggat gcaatatgca ctttaatatg taaggcatta acagatgaag 8341 agtattactc ggcattaaaa gagaatgctc ggatccaggc acaaaaattt tcgtggaata 8401 tttctgccga gcgagcaatt gcagctatgg agaaattatt agacagtcag tcgcagagca 8461 caaatcgaac agatattcac aataatatag tgaatatatc agagataact gagttaacac 8521 ctaatgagca attaagagca gcttgggcca ttgccagaaa taatttcact cagcataaac 8581 gcaaaatttt agttgatatc tcggtgcttg tgcaccatga tgcaaaaaca gggattcaaa 8641 gggtttctcg tagtatatta actcaattac gtaaaattga cttgcatgga tatgaagtct 8701 atcccgttta ctatacacat ggcgaatatt atcgctatgc caatcgtttt acagctgata 8761 actttgactc cggtttaaaa agtgataatc cggtattatt tacaaaagac gatatattac 8821 ttgtcgcgga tttaacggca catttattcc cggatattat tcctgaaatt aattacatac 8881 gaaaggcagg ggctaaggca gtatttattg tatatgatat actaccaatt cttcatcctg 8941 aatggtgtgc ggaaagtatc aggcaagcat ttcctctatg gttgaaaggc ttagtgagct 9001 gcgctgatca gctaatttgt atttctgaaa gtgtagctaa tgaagtaaga aactggattg 9061 atgcacagga gacagatgtt aacccttacc tgatggtaga tagtttccat ttgggtgcag 9121 attttgaagg tagtttgcca tctaagggaa tgcctgagac agccacggct tttcttgcag 9181 gtatgagctc agttcctact ttccttatgg tagggaccct tgaaccgcga aaaggtcatt 9241 ctcaaacact tgcagcattt aagcaacttt ggtcggaagg atatgatttt caattatgta 9301 tagttggaaa acagggttgg aatgttgaga gtttaatctc tgaaattgaa aatagcgatg 9361 aacttaataa taagttgttc tggctacaaa atatcagtga tgaatatttg gatgctatat 9421 atgctaatgc ctgcgctcta atttttgcat ccaatggtga aggatttggt cttccgttaa 9481 tagaagcggc tcaaaagaat attcctttaa ttattcgtga tattcctgta tttaaagaaa 9541 ttgcagagtc taacgctttc tattttcatg ggcaaaaacc tgatgatctt aagaatgcaa 9601 ttattgaatg gcataaactt tacactaacc acactcatcc tacatccgca ggtataaaat 9661 ggcagacatg gcggcagagt gtagaacagt tattaaataa acttcctatt actaaagagt 9721 gctaaatatt gttcgtttta gtattgagca aaagctaata acttttttca aagtttaatt 9781 actggataag gtggatagtg agtgatataa tcacaatttg ctttatttgt actcacatta 9841 atcaaaggtt aaaataatga agtccgcaat tattactggt atcactggac aagatggtgc 9901 ttatcttgct gaacttttgc ttggtaaagg gtataaagta tatggtacat accgccgtac 9961 cagctctgtt aatttctggc gaattgaaga actaggtatc aaaaacaatc ccaatttgca 10021 tcttgttgaa tatgatctga cagatctttc tgccagtatt cgtctaatgc aaacaacgaa 10081 tgctacggaa gtatacaacc ttgctgcaca aagttttgtc ggtgtttctt ttgaccaacc 10141 ggtcacaact gctgaaatca caggtcttgg tgcagtaaac ctgcttgaag caattcgaat 10201 tgttaacccg cagatccgtt actaccaggc ttcaacttct gaaatgtttg ggcttgtaca 10261 agccgttccg caaaaagaag acacaccatt ctatccacgc agtccgtatg gtgttgctaa 10321 actgtatgct cactggatga ctgtaaacta ccgtgagagc tataacattt ttgcttccag 10381 cggtatcctg tttaaccatg aatctccctt acgtggtcag gaatttgtaa cacgcaaaat 10441 tacagattcc gtagcaaaaa ttaagcttgg taagcaagat gttctggaac tagggaacat 10501 ggatgccaag cgtgactggg gttatgcaaa agaatatgtt gaaggtatgt ggcgtatgct 10561 gcaggctgat aagcctgata cctttgttct ggcaacaaat cgaaccgaga ccgttcgtga 10621 ctttgtcagc atggctttca aagctgctgg gtttacgctg cgctttgaag gaaaagatga 10681 gaatgaagta ggtattgatg tcgcgactgg taaaactttg gtccgcgtaa atccgaaatt 10741 ctaccgtcct gctgaggttg atctgttgat tggtaatcct gcgcgagcga aagagattct 10801 tggttgggaa ccaaaaacta cccttgagca actttgccag atgatggtag aggctgatct 10861 acgtcgtaat caacagggaa tgaccttctg atgactgatg ccggaaaaca tgccttaatt 10921 acagggatca atgggtttac cggccgttat gtggcagcgg aactttccgc tgccggatat 10981 cgcgttttcg ggctaggagc agggtctgtc ccttatgacg gacctgatta ttatcaggta 11041 gatctaatgg atgttacggc attaaccaat gtcgttacct cgataaaacc caatgtagtc 11101 gtacacctgg ccgcaatcgc ttttgtaggt cacggtgatg cagatgcatt ttataatatc 11161 aacttgcttg gcacccgtaa tttattacag gcacttagtc actgtgataa ctcattagat 11221 gcggtacttc ttgccagtag tgcgaatgtt tatggaaacg gtacagccgg aaagttaagt 11281 gaaacaacgg cacctaatcc ggcaaatgac tatgcagtta gtaaattggc gatggaatat 11341 atggctcgcc tctggatgga caaactaccg gtatttatta ccaggccttt taactataca 11401 ggtgttggtc aggctgataa ttttttattg cctaaaattg ttaaacattt taaagccaaa 11461 gctccggtga ttgagcttgg taatattgat gtgtggagag atttcacaga tgttcgtgcg 11521 ttaagtcagg cttatgtgaa gctacttcag gcaaaaccca ctggagaagt gataaacatt 11581 tgctcagggc gcacatactc actaagaaaa attattgaat tatgtgaaaa aattaccggt 11641 catcacctcg aaattcaggt taaccaagcc tttgtacgtg ctaatgaagt taaaacatta 11701 agtggagata ccactaagct tcagtctttt atacctgagt gggatgtccc accccttgaa 11761 gacaccttac gttggatgtt ggaaagtgac taatgaaagt aatatttgga actgatgcta 11821 ttaaattccc attaactggt atcggccgct atgcgtttga attagctaat catttagctg 11881 gcagcccgga aatatccgag ctgctttatt tacgtggaaa aacgctcagt actcatattc 11941 ctattgcaaa agaggcacat tcttctgctg agggtattaa gcattttttg aaaaaaaacc 12001 gtttggcatc tgagttctac cgcattaccg caccatggtt taaaacaaat gttcttagaa 12061 aacataaaga tgcaatatat catgggccaa atttttattt accccctaaa gttgggcgat 12121 gcgtagtcac ttttcatgat ttatctgtat ttaccttacc gcaatgtcat ccgcctgaac 12181 gggttagata tatgcgtaaa gagttactgc aaaccgttag aagggctgaa atttttttaa 12241 cagattctga ttttacgaga agtgaattga ttaattactt taatctgcca gaatcacaag 12301 tttataccgc aaaactggca tgtagcaggg attatcgacc ttattcctac tttgaagcta 12361 ctgaaacttt acgcaaatac aatcttagtt ttaaaaatta tactttattt attggatcta 12421 ttgagcctcg aaaaaatatt agtactcttt taaccgcata caaccgtcta cctttatctc 12481 taagacaaag ggtgcctctg gttataagtg gctttaaagg ttggaatagt gatgatctcc 12541 ataagcgttt catgaagggc gagcgagaag ggtggttacg ttatctcgga tttacccctt 12601 atgcagatct acctgctttg tatgcaggtg ctacaacatt cattttcccg tcaatttatg 12661 agggttttgg tcttccagta cttgaggcta tggcctctgg tacacctgtt gtttgttcaa 12721 acagttcctc actaccggaa gtagttgggg atgtcgcttt gatgtgtgat gctttggatg 12781 tcgagacgct tacaactttg ataataaaaa gtcttgaaga tgacccctgg agactgtggg 12841 caggggaaca tggaatacaa cgtgccagtc aattttcttg ggaaaggtgt gctagcgaaa 12901 caatcactgc atataaacag gtaatataaa tttaatgttg aaagtattac atttttataa 12961 aacatactat cctgatacgt ttggtggcat agaacaggtt atataccagt taagtgaatc 13021 cggacttaac ttcggagttg aatcaacagt tttatcactc agcaaacgag gggattatga 13081 taacgaaaaa tttggttcac atcgtgttta ttatgcgaaa acaaattttg aaatagcctc 13141 aacccctttt tcagtgtcat caataagtaa attccgaaag ttggcaaaag aggctgatat 13201 tatacattat catttcccct ttccttttat ggatatgctg cattttatcg atgggattaa 13261 taaaccctca atagtaagct accattctga tatcgtcaaa cagaaatctt ttttacgtct 13321 gtattccccc ttaatgaatc attttttggc tgctgtagat tatattgtta ctgcttctcc 13381 aaattatgca caaacaagtc cagtactaca aaaatttaaa aataaagtta aagtcatccc 13441 atacggttta aatgaaagtt cttattcact tatccctgct gaaaaactgg aatattggag 13501 acagaaagtt ggtgataagt tttttctttt tataggtgca ttccgttatt acaaaggatt 13561 gcatacatta ttagatgcag cgtacacgac atcgctacca attgttatcg ttggcagcgg 13621 tggaatagag aaggaaatac gattaagagc taatcagctt aacctttcaa atgttcattt 13681 tgtaggtgca ttacctgaag atgataaagc tgctttatta caactttgct atgcagttgt 13741 gttcccatca catcaacgtt ctgaggcttt tggaattacg ttgcttgagg gggctatgta 13801 tggtaaacct ttaatctctt gtgagatcgg aacaggaacg agttttatta atattgatgg 13861 tcaaacagga ttggtagtgc ccccttctaa ttcttacgcg ctcagagaag ctatgttgaa 13921 attatgggat tcaccgttac tagctgagat ctatgggcaa aatgcgttct atagatttaa 13981 ggagttattt acttctaaca atatgtgtaa gaaatatgtt gagttatata caagattagt 14041 atcttgatat tatttcccct attttattga caacataata ctaagatttt tttatgaata 14101 taaaacatgt gcgtgaatat tataattttg aatacgcaat tccctttttc gttggtatga 14161 ttttttttgg tgttgctttt aattatgata taatctcacc atctaatatt agctggttag 14221 taggagatcg tcttcaatct tatctaggtt gggaatactt ccgacatgct ccttggcaat 14281 ttccagtggt aggccgtaca aactacggaa tggaattgtc ttcatcgatt gtttttaccg 14341 attctaatcc gtggctatcg attctactta aacctttttc ttcttttttg ccatcgactt 14401 tccagtttgg cggtgcttgg ttattattat gtgttatagc acaagccata atattatgga 14461 aaattatttc tatatatact caaaacaatt gcattaaaac aattgcatta gtatttatgt 14521 tatttaatcc tgcatggata aatagaactg ggcatttaat gttgatgtct ttttttatat 14581 ttaccgcagg catatatctt agcttgaaat atagtaaaac tactagcttc aataatgcta 14641 aatggctttt attactctgc atcgctatcg gaacacactt ctatatatat ctgttaattt 14701 ttattaattg gtttgttatt gttttttatg cttttttatg tgaacccgct aatagaaaga 14761 aaatcatatt gagtttcttt ttgaatatat tagttagctt ttctctcttt tatgtgtttg 14821 gctacttaac tataggagga ggtgccagcg cgggaggttt tggcttttat aaagcaaacc 14881 ttttgttccc aattttagct ggtggtaact cagagattat cggattgaat tttttccatc 14941 cgggagaata tgaggggtat aattatttcg gtggagggct aatactactt ataataataa 15001 atattttctt tgggaaagtt gatctattta gcgtggtgaa gaataatgtt ccactatttt 15061 tattctcttt aatttgtttt gtgttagcga tttctaatgt tattgctatt ggtgataatg 15121 agtttactat acctttacca aatatactgc taaatatctt aagcaatttt cgtgcgtctg 15181 gtagatttct ttggccagtt gtcatgttaa tattttttat atttcttttc gcgtacaatg 15241 aaatttcctg gtaaatggcc ttggttaata ctgttaatat gcacatctct acaaatatat 15301 gatatttcca aatcgtggct acataatcat aactccttaa tatcaaacgc agtgaataac 15361 tccacacgtt ttgaagaata ttcaatgttg tggaataaac atctatcagt ttataaaaat 15421 attagatggt tccctacaca aaattcagga cctaaatggt cagaaatttc gtatttatca 15481 aacaaatata atcaaaatac tgatgctatt tactatgcac gtgtagacga aaaaaaactt 15541 agtgcgacaa tgaagaaagt ttctctccag ttattgtttg gtaattatga atttaatact 15601 gcttatttaa tggataagga ttattcaagt ttaattaaat taaaaaaagg tgatgcgatt 15661 tataaatata aagatctata tatattaatg cctggtaata attcttgtga tgactgtgat 15721 attgttaata cctctaatgt gcaacaaaga gattttgatt tttcaatcgg tggtataggc 15781 aggatattat taggggatgg ttggtattct cctgaagcat ggggggtatg gagccaaggt 15841 gatgtctctg agatttttat accaggcgat accaaaaatg ttgagatata tttcgatggc 15901 tttttggttc caggcaaacg agagcacttt aatgtttctt tttattgtgg gcaagaaaaa 15961 atatcacaac tggatgtaac ccctaaatca actcgggaag tcttattaaa cgtaagtgga 16021 tgcatcaaaa acgaagataa tgctattaaa cttacagtga ggaatgataa cccaggtatt 16081 cctaaaatgc tttttcctaa taatgaagat tcaagattga ttgcgtttgg cttgaaaaaa 16141 atcattatgc attaattgac ttaaattatt gtaacctagg gtttgtctgt aatgtattat 16201 taacttaagt agtcacagtc caatcgtgca ataataaatg ttatagctgc aaaatattct 16261 gttctaatga aagatagatt tctctatcat tagaattcca agaaagagtc ctatcttctt 16321 gatatgcaaa gtgacaggag tagaaaatgt ccaagcaaca gatcggtgtt gtcggtatgg 16381 ctgtaatggg ccgtaatctc gcgctcaata ttgaaagtcg tgggtatacc gtctctatct 16441 ttaaccgttc ccctgaaaaa accgaagagg ttattgcaga aaatccgggt aagaaattag 16501 taccctatta tacggtaaaa gagtttgttg aatctcttga aaaacctcgc cgtattctgt 16561 taatggtgaa ggctggggca gggactgatg ctgctattga ttctctcaaa ccgtatctgg 16621 ataaaggcga tatcatcatt gatggtggta acaccttctt tcaagacaca attcgccgca 16681 atcgtgaact atctgaacaa ggttttaatt tcatcggtac tggtgtttct ggcggcgaag 16741 agggggctct caaaggcccg tcaatcatgc ctggtggcca gaaagaagcc tatgaacttg 16801 tcgctccgat tctgacaaag atcgcggctg tagcagagga tggggaacct tgcgtaacgt 16861 atatcggtaa tgatggagcg ggtcattatg tcaagatggt tcacaatggc atcgaatatg 16921 gtgatatgca acttattgca gaagcttatt ccttgcttaa agatgggtta actctgtcaa 16981 acaatgaact tgcaggaatc tttactgaat ggaataacgg cgaacttagc agctatctta 17041 tcgatatcac taaagatatt ttctccaaaa aggatgaaga aggggattat cttgttgatg 17101 ttattcttga tgaagccgct aacaaaggaa ctggtaaatg gaccagtcaa agcgcccttg 17161 atctcggtga acccttatcg cttataactg aatcggtatt tgctcgctat atatcttctt 17221 taaaggatca gcgtgtcgca gcatcgaaag tactaacggg gcctgttgcg aaacctgtta 17281 gtaacaaaga agagtttgtt gaaaaggtac gccgcgcatt ataccttgga aaaattgttt 17341 cgtacgcaca aggtttttca caattacgtg ctgcttctga gcaatatgac tggaatctta 17401 actacggtga aatagccaga attttccggg ccggctgtat tattcgcgct caatttttac 17461 agaaaattac tgatgcttat tcagaaaatc cgaatattgc gaatttactg ttggctcctt 17521 acttcaagaa tattgctgat aattatcagc aagctttacg tgatgttgtt gcctatgcgg 17581 ttcaaaatgg cattccagta ccaacgtttt ctgccgcaat tacttattac gacagttatc 17641 gctccgcggt tttgcctgcg aacctgatcc aggcgcagcg cgact //