LOCUS AL645882 23112 bp DNA linear CON 06-FEB-2015 DEFINITION Streptomyces coelicolor A3(2) complete genome. ACCESSION AL645882 REGION: 3831534..3854645 VERSION AL645882.2 DBLINK BioProject: PRJNA242 BioSample: SAMEA1705940 KEYWORDS complete genome. SOURCE Streptomyces coelicolor A3(2) ORGANISM Streptomyces coelicolor A3(2) Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group. REFERENCE 1 (bases 1 to 23112) AUTHORS Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J., Kinashi,H. and Hopwood,D.A. TITLE A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome JOURNAL Mol. Microbiol. 21 (1), 77-96 (1996) PUBMED 8843436 REFERENCE 2 (bases 1 to 23112) AUTHORS Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L., Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H., Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M., Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S., Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S., Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S., Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S., Taylor,K., Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G., Parkhill,J. and Hopwood,D.A. TITLE Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) JOURNAL Nature 417 (6885), 141-147 (2002) PUBMED 12000953 REFERENCE 3 (bases 1 to 23112) AUTHORS Bentley,S.D. TITLE Direct Submission JOURNAL Submitted (09-MAY-2002) Submitted on behalf of the Streptomyces sequencing team, Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA E-mail: sdb@sanger.ac.uk FEATURES Location/Qualifiers source 1..23112 /organism="Streptomyces coelicolor A3(2)" /mol_type="genomic DNA" /serovar="A3(2)" /db_xref="taxon:100226" regulatory complement(1..4) /regulatory_class="ribosome_binding_site" gene complement(172..1101) /gene="SCO3471" /gene_synonym="dagA" /gene_synonym="SCE65.07c" CDS complement(172..1101) /gene="SCO3471" /gene_synonym="dagA" /gene_synonym="SCE65.07c" /note="SCE65.07c, dagA, extracellular agarase precursor, len: 309 aa; identical to previously sequenced SW:AGAR_STRCO (EMBL:X05811) Streptomyces coelicolor extracellular agarase precursor (EC 3.2.1.81) DagA, 309 aa and similar to TR:Q59078 (EMBL:M73783) Alteromonas atlantica (Pseudomonas atlantica) beta-agarase I precursor (EC 3.2.1.81), 290 aa; fasta scores: opt: 385 z-score: 446.1 E(): 1.8e-17; 33.2% identity in 304 aa overlap. Contains match to Prosite entry PS01034 Glycosyl hydrolases family 16 active sites. Contains N-terminal region signal sequence peptide" /codon_start=1 /transl_table=11 /product="extracellular agarase precursor" /protein_id="CAB61795.1" /db_xref="GOA:P07883" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR016287" /translation="MVNRRDLIKWSAVALGAGAGLAGPAPAAHAADLEWEQYPVPAAP GGNRSWQLLPSHSDDFNYTGKPQTFRGRWLDQHKDGWSGPANSLYSARHSWVADGNLI VEGRRAPDGRVYCGYVTSRTPVEYPLYTEVLMRVSGLKLSSNFWLLSRDDVNEIDVIE CYGNESLHGKHMNTAYHIFQRNPFTELARSQKGYFADGSYGYNGETGQVFGDGAGQPL LRNGFHRYGVHWISATEFDFYFNGRLVRRLNRSNDLRDPRSRFFDQPMHLILNTESHQ WRVDRGIEPTDAELADPSINNIYYRWVRTYQAV" misc_feature complement(173..1911) /note="previously sequenced fragment (EMBL:X05811) 100% identity" misc_feature complement(604..639) /gene="SCO3471" /gene_synonym="dagA" /gene_synonym="SCE65.07c" /note="PS01034 Glycosyl hydrolases family 16 active sites" regulatory complement(1109..1112) /regulatory_class="ribosome_binding_site" gene complement(1455..1718) /gene="SCO3472" /gene_synonym="SCE65.08c" CDS complement(1455..1718) /gene="SCO3472" /gene_synonym="SCE65.08c" /note="SCE65.08c, possible transposase remnant, len: 87 aa; similar to TR:P71428 (EMBL:X02734) Lactobacillus casei transposable element ISL1, 93 aa; fasta scores: opt: 98 z-score: 145.6 E(): 0.91; 31.5% identity in 54 aa overlap and to Streptomyces coelicolor SCE65.24, 114 aa; fasta scores: opt: 76 z-score: 102.7 E(): 2.3; 40.6% identity in 32 aa overlap" /codon_start=1 /transl_table=11 /product="putative transposase remnant" /protein_id="CAB61796.1" /db_xref="GOA:Q9RKG5" /db_xref="InterPro:IPR002514" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/TrEMBL:Q9RKG5" /translation="MGSKYTKRYLEEYKRDAIELVRSSGRTVTEAARELGISRSEPFQ VRYGFGRDFSRTPETRGRCVGASAGHPHLPRRALGMPCTGRPA" regulatory complement(1730..1734) /regulatory_class="ribosome_binding_site" gene complement(2522..3169) /gene="SCO3473" /gene_synonym="SCE65.09c" CDS complement(2522..3169) /gene="SCO3473" /gene_synonym="SCE65.09c" /note="SCE65.09c, probable aldolase, len: 215 aa; similar to SW:ALKH_BACSU (EMBL:L47838) Bacillus subtilis KHG/KDPG aldolase AlkH, 347 aa; fasta scores: opt: 457 z-score: 523.2 E(): 9.1e-22; 39.5% identity in 200 aa overlap and to Streptomyces coelicolor SCE65.31c, 225 aa; fasta scores: opt: 424 z-score: 429.4 E(): 1.5e-18; 37.7% identity in 215 aa overlap. Contains Pfam match to entry PF01081 Aldolase, KDPG and KHG aldolase and match to Prosite entry PS00160 KDPG and KHG aldolases Schiff-base forming residue" /codon_start=1 /transl_table=11 /product="putative aldolase" /protein_id="CAB61797.1" /db_xref="GOA:Q9RKG4" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="UniProtKB/TrEMBL:Q9RKG4" /translation="MPRYETASRIARDGVVAVVRSHSPDLAREQALALLKAGQRVVEV SMTTPGALDVVADLSHGWPAHEALIGVGTVLDEATVRMSELAGARFVVSPTVNRTVLR AAHRYGMATLAGALSPTEAATAIEEGADFVKLFPASVYGADAVRHLLAPFPQLALVPT GGVPLELAPDYIRAGAVAVGIGSELTSGDPRSIEGRVRQLRTAVAREKAERTARA" misc_feature complement(2570..3118) /gene="SCO3473" /gene_synonym="SCE65.09c" /note="Pfam match to entry PF01081 Aldolase, KDPG and KHG aldolase, score 71.80, E-value 1.4e-17" misc_feature complement(2747..2788) /gene="SCO3473" /gene_synonym="SCE65.09c" /note="PS00160 KDPG and KHG aldolases Schiff-base forming residue" regulatory complement(3174..3178) /regulatory_class="ribosome_binding_site" gene complement(3208..4209) /gene="SCO3474" /gene_synonym="SCE65.10c" CDS complement(3208..4209) /gene="SCO3474" /gene_synonym="SCE65.10c" /note="SCE65.10c, possible sugar kinase, len: 333 aa; similar to SW:KDGK_BACSU (EMBL:L47838) Bacillus subtilis 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) KdgK, 324 aa; fasta scores: opt: 500 z-score: 585.4 E(): 3.1e-25; 34.1% identity in 299 aa overlap. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase" /codon_start=1 /transl_table=11 /product="putative sugar kinase" /protein_id="CAB61798.1" /db_xref="GOA:Q9RKG3" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="UniProtKB/TrEMBL:Q9RKG3" /translation="MTRPVVEGGPAVVCLGETMAQIVPIDGLRLHEASACAFGVAGAE SNVAISLSRLGTAAFWAGFVGDDPMGLRVLGELRRHGVVTKLARTMPGRRTGVYFKDP APEGSDIYYYRSGSAATLMDGEYAERIAAVRPRWIHLTGVTPALSENCREAVISLIEL AGDTGASVSFDVNYRPSLWPARDAAAQSLMAIADRCNVVFVGLDEAQTLWKSCTAGAV RDHLPSPDVVVVKDGGREAVAFRGGRRTAVPALPVDVVEPVGAGDAFAAGWIHGALVG LDEAGCLRLGHLLAGAAMTSLSDVADLPTAPAALVARAKHGNEWPGHGSPAEASPHP" misc_feature complement(3406..4089) /gene="SCO3474" /gene_synonym="SCE65.10c" /note="Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 85.30, E-value 8e-26" regulatory complement(4220..4223) /regulatory_class="ribosome_binding_site" gene complement(4337..5470) /gene="SCO3475" /gene_synonym="SCE65.11c" CDS complement(4337..5470) /gene="SCO3475" /gene_synonym="SCE65.11c" /note="SCE65.11c, possible isomerase, len: 377 aa; similar to SW:ATB_RHOOP (EMBL:X99622) Rhodococcus opacus muconate cycloisomerase I (EC 5.5.1.1) CatB, 373 aa; fasta scores: opt: 390 z-score: 443.3 E(): 2.6e-17; 31.1% identity in 357 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="CAB61799.1" /db_xref="GOA:Q9RKG2" /db_xref="InterPro:IPR001354" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR018110" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="UniProtKB/TrEMBL:Q9RKG2" /translation="MRIVKVRTFHVRPRWLFVAVETDKGVIGWGEAVVEGQARVVERM IGDLAEYLAGRDPRRIEHHWQGMYRGAFYRGGAVLCSAISGIDQALWDITARDLGVPV HALLGGAVRDSVRMYGHARGVTDAEFAHAARRSRSAGMTAIKFGLDGPVRALDTVEYV DRQVARVAAVREAVGPAFDIALDFHGRTSPAMARRLAERLSPMGPLFIEEPCLPENVD ALAEIARATNVPIAAGERIFTKWGFRELLERRAVSVVQPDLCHAGGISEVRRIAAMAE AHYVALAPHNPLGPVSLAACLQVAASTPNFLIQEYLALDDGADLGAGILAVPFSVENG HIAVPTGPGLGIEVDEAQLMDRVYAGDWTTPRFTHQDGSHGDW" misc_feature complement(4457..5461) /gene="SCO3475" /gene_synonym="SCE65.11c" /note="Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family, score 298.10, E-value 1.1e-85" misc_feature complement(4838..4933) /gene="SCO3475" /gene_synonym="SCE65.11c" /note="PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2" misc_feature complement(5150..5227) /gene="SCO3475" /gene_synonym="SCE65.11c" /note="PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1" regulatory complement(5480..5483) /regulatory_class="ribosome_binding_site" gene complement(5683..6438) /gene="SCO3476" /gene_synonym="SCE65.12c" CDS complement(5683..6438) /gene="SCO3476" /gene_synonym="SCE65.12c" /note="SCE65.12c, probable dehydrogenase, len: 251 aa; similar to SW:KDUD_BACSU (EMBL:L47838) Bacillus subtilis 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) KduD, 254 aa; fasta scores: opt: 833 z-score: 937.8 E(): 0; 52.0% identity in 248 aa overlap and to Streptomyces coelicolor SCI30A.02, 253 aa; fasta scores: opt: 605 z-score: 622.2 E(): 2.7e-29; 44.1% identity in 245 aa overlap. Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature" /codon_start=1 /transl_table=11 /product="putative short-chain dehydrogenase" /protein_id="CAB61800.1" /db_xref="GOA:Q9RKG1" /db_xref="InterPro:IPR002198" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR020904" /db_xref="UniProtKB/TrEMBL:Q9RKG1" /translation="MISSFDLTGRTAVVTGGGRGLGLGISRALLNAGADVVVLSRSAL DDRLRRTAADLGRSVSHVGVDLRDREGVAAAGAEVLAGHQVDILVNNAGAQIRHPAED FPLDAWDAVLDVNLRSVVQLCQIFGRPMIQRGEGKIINLASLLSFQGGFTVAAYAASK GAVAQLTKALCNEWAGRGVNVNAIAPGYMATEMNTALLEDPVRLEQLSVRIPAGRWGG PDDVGDVAVFLASRAAAYVHGQVLAVDGGWLAR" misc_feature complement(5707..5799) /gene="SCO3476" /gene_synonym="SCE65.12c" /note="Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus, score 50.50, E-value 3.6e-11" misc_feature complement(5863..6411) /gene="SCO3476" /gene_synonym="SCE65.12c" /note="Pfam match to entry PF00106 adh_short, short chain dehydrogenase, score 208.70, E-value 9.1e-59" misc_feature complement(5926..6012) /gene="SCO3476" /gene_synonym="SCE65.12c" /note="PS00061 Short-chain dehydrogenases/reductases family signature" gene complement(6435..7469) /gene="SCO3477" /gene_synonym="SCE65.13c" CDS complement(6435..7469) /gene="SCO3477" /gene_synonym="SCE65.13c" /note="SCE65.13c, possible dehydrogenase, len: 344 aa; similar to TR:CAB50292 (EMBL:AJ248287) Pyrococcus abyssi threonine 3-dehydrogenase (EC 1.1.1.103) 348 aa; fasta scores: opt: 567 z-score: 616.8 E(): 5.6e-27; 33.8% identity in 328 aa overlap and to SW:TDH_BACSU (EMBL:Z99112) threonine 3-dehydrogenase (EC 1.1.103) Tdh, 347 aa; fasta scores: opt: 544 z-score: 592.1 E(): 1.3e-25; 31.4% identity in 331 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="CAB61801.1" /db_xref="GOA:Q9RKG0" /db_xref="InterPro:IPR002085" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR016040" /db_xref="UniProtKB/TrEMBL:Q9RKG0" /translation="MTGGMSAVVWAGVNDVRVEEVPMPEVPPGWALVRVACTGICGTD LGIVHGKHPRARQGLILGHEISGWVEVTAPGGPPEGALVVAEPLISCKDCRACREGHS HVCARLGLFGIDAPGGAAQFVALPTSTLHQVPSRVEPTQAALTEPLAVAVHAVSRSGM EAGDVVAVFGAGPIGILTALVARHEGASHVVVAEPNARRRAVASDMGLIAVPDGAQLR DMVAELSQGDGADTTFDSAAHPAVAAELADVTRVLGRVVIVGVYKEPAAVDLQAVCFK EQSVVGVRVYTREDFRTAIDLVAQNALGLDRFPVSVYGFDRISDAFDAAATGSGGLKV LISTHRDEAT" misc_feature complement(6459..7454) /gene="SCO3477" /gene_synonym="SCE65.13c" /note="Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases, score 148.10, E-value 1.5e-40" gene complement(7466..8500) /gene="SCO3478" /gene_synonym="SCE65.14c" CDS complement(7466..8500) /gene="SCO3478" /gene_synonym="SCE65.14c" /note="SCE65.14c, probable dehydrogenase, len: 344 aa; similar to TR:O50095 (EMBL:AP000006) Pyrococcus horikoshii 307aa long hypothetical phosphoglycerate dehydrogenase PH1387, 307 aa; fasta scores: opt: 687 z-score: 777.1 E(): 0; 40.5% identity in 291 aa overlap and to SW:SERA_METTH (EMBL:AE000870;) Methanobacterium thermoautotrophicum D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) SerA, 525 aa; fasta scores: opt: 664 z-score: 748.1 E(): 0; 39.0% identity in 282 aa overlap. Contains Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases and match to Prosite entry PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="CAB61802.1" /db_xref="GOA:Q9RKF9" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR029753" /db_xref="UniProtKB/TrEMBL:Q9RKF9" /translation="MIRLMTAMRTAGGGPLVAITECDHDSFDIERDVVTSAGGQLLVT QSRDADTMVVNCAGADAIVVQYAAITEQVMDRLPRLKVIGRYGVGVDSVDVEAATRRG ILVCNVPDYGTEAVSDHAIGLALSVARGIPRLDRGVRAGSFDLPAVRPLYQVGQRVFG VVGMGLIGAATARKAAGLGYDVIAYDSAADPDAQTFRGFRSVGLHELLERAQVVSVHT PLTEQTRGLLGADAFARMRPDAIVVNTSRGGVIDTGALVDALKRGAVAGAGIDVHEIE PLPRDHPLTSFDNVVLTPHLAWYSEESYAELKRRTVENVVDACAGRTPRNVVNPEALP AAAQRSEGRR" regulatory complement(7477..7481) /regulatory_class="ribosome_binding_site" /gene="SCO3478" /gene_synonym="SCE65.14c" misc_feature complement(7616..8236) /gene="SCO3478" /gene_synonym="SCE65.14c" /note="Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases, score 237.30, E-value 7.1e-97" misc_feature complement(7814..7882) /gene="SCO3478" /gene_synonym="SCE65.14c" /note="PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2" regulatory complement(8502..8505) /regulatory_class="ribosome_binding_site" gene complement(8862..11849) /gene="SCO3479" /gene_synonym="SCE65.15c" CDS complement(8862..11849) /gene="SCO3479" /gene_synonym="SCE65.15c" /note="SCE65.15c, possible beta-galatosidase, len: 995 aa; similar to SW:BGAL_ECOLI (EMBL:J01636) Escherichia coli beta-galactosidase (EC 3.2.1.23) (lactase) lacZ, 1023 aa; fasta scores: opt: 1594 z-score: 1693.3 E(): 0; 33.6% identity in 1039 aa overlap. Contains Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family and match to Prosite entry PS00719 Glycosyl hydrolases family 2 signature 1" /codon_start=1 /transl_table=11 /product="putative beta-galatosidase" /protein_id="CAB61803.1" /db_xref="GOA:Q9RKF8" /db_xref="InterPro:IPR004199" /db_xref="InterPro:IPR006101" /db_xref="InterPro:IPR006102" /db_xref="InterPro:IPR006103" /db_xref="InterPro:IPR006104" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR013781" /db_xref="InterPro:IPR013812" /db_xref="InterPro:IPR014718" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR023230" /db_xref="UniProtKB/TrEMBL:Q9RKF8" /translation="MLPIIGALRPWADPTMTSLLRLPMRARPAAEGDRRLSLDGTWSF RLFPSPDQVPADAVRGERAPGQWQSVDVPGSWPVQVADDIPHYTNIQMPFAEPPPRLP SRNPTGVYRTGFDVPSHWEGQRLLLHVGGADSVHAVYLNGVFVGYGTDARLGSEYDVT EAARVGRNQLAVVVVRYSAHSFLEDQDGWWLAGLHRGVRVEARPPVGLVDLDARADLD PRSGEGSLDVRATVDFGESTAAEGYRVRVSLSGRDGAGVAGPQDAPVPHAVNNTYEFS GHIARLHRDGLRILPWSAETPTLYEVAAELIDPAGDVVDATRVRVGFRRVEIDGPDFL VNGRRVWIFGVNRHDHHPDTGAAVTAEDMRADLAAMRRMNINAIRTSHYPNDPAFYDL CDELGFYVVDEANIESHAFNWYLCGDPRYRATWLERGARMVARDRNHPCVVQWSLGNE SGYGVNHDALAGWIRRADRSRPLHYEDAIRNSGWTDGGRHATDVVCPMYPGIEEIRAY GEQVAAGAADRPLIMCEYSHAMGNSNGSLADYWDVITSTPGLQGGFIWEWKDHGLRQR LPDGTTRLAYGGQFGDAPHDANFVADGLVSADVEPHPGTAEVAWVYRPVTTEYVDGGL YVTNRRRFAGTGDLAAGWELLLDGAPSASGTLDVPDIAPGGSVAVPLPADAARAGAAQ ALLTITWRTRTESWFAPAGHPVAWDQLALRDGRTAPGPPVNGAVAVPGETADDPVPNV WRAATDNDGLKLMEHIVRVREMGSRTLIRWRDAGLDTRPAHEIVDHTVSVSRSESGAD YRHRFEVPDEAADLPRVGVLFRVDPRFDRFVWFGRGPHENYPDRNRSAMLGRWSSHVE PSPYLVPQEFGLRTGTLWLELIDDDRGDRLRLTSLGGDFCWSATRYAPQALFAAGNAS DLREDGRLVVCLDAAHRGVGTGACGPDVLPEYRIGPGRYELAYRMELVPAVQGVAGAP PHPQDSSRAASGGGSQCKDRHVG" misc_feature complement(10026..11756) /gene="SCO3479" /gene_synonym="SCE65.15c" /note="Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family 2, score 561.00, E-value 7.7e-165" misc_feature complement(10647..10724) /gene="SCO3479" /gene_synonym="SCE65.15c" /note="PS00719 Glycosyl hydrolases family 2 signature 1" gene complement(11990..13075) /gene="SCO3480" /gene_synonym="SCE65.16c" CDS complement(11990..13075) /gene="SCO3480" /gene_synonym="SCE65.16c" /note="SCE65.16c, possible racemase, len: 361 aa; similar to TR:CAB55709 (EMBL:AL117387) Streptomyces coelicolor possible racemase SCF41.06, 416 aa; fasta scores: opt: 471 z-score: 557.6 E(): 1.1e-23; 32.6% identity in 328 aa overlap and to SW:MANR_PSEPU (EMBL:M19043) Pseudomonas putida mandelate racemase (EC 5.1.2.2) MdlA, 359 aa; fasta scores: opt: 473 z-score: 561.0 E(): 7.2e-24; 27.8% identity in 363 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family and match to Prosite entry PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2" /codon_start=1 /transl_table=11 /product="putative racemase" /protein_id="CAB61804.1" /db_xref="GOA:Q9RKF7" /db_xref="InterPro:IPR001354" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR018110" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="PDB:2OVL" /db_xref="PDB:3CK5" /db_xref="UniProtKB/TrEMBL:Q9RKF7" /translation="MIERVRTDLYRIPLPTRLTDSTHGAMMDFELITVRIEDSDGATG LGYTYTVNHGGAAVATMVDKDLRGCLLGADAEQIEKIWQSMWWRLHYAGRGGHATSAI SAVDIALWDLKGIRARTPLWKLFGGYDPVVPVYAGGIDLELPVADLKTQADRFLAGGF RAIKMKVGRPDLKEDVDRVSALREHLGDSFPLMVDANMKWTVDGAIRAARALAPFDLH WIEEPTIPDDLVGNARIVRESGHTIAGGENLHTLYDFHNAVRAGSLTLPEPDVSNIGG YTTFRKVAALAEANNMLLTSHGVHDLTVHALASVPHRTYMEAHGFGLHAYMAEPMAVT DGCVSAPDRPGHGVVLDFERLGRLAVG" misc_feature complement(12056..13075) /gene="SCO3480" /gene_synonym="SCE65.16c" /note="Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family, score 144.80, E-value 1.5e-39" misc_feature complement(12407..12502) /gene="SCO3480" /gene_synonym="SCE65.16c" /note="PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2" gene complement(13137..14249) /gene="SCO3481" /gene_synonym="SCE65.17c" CDS complement(13137..14249) /gene="SCO3481" /gene_synonym="SCE65.17c" /note="SCE65.17c unknown, len: 370 aa" /codon_start=1 /transl_table=11 /product="hypothetical protein SCE65.17c" /protein_id="CAB61805.1" /db_xref="GOA:Q9RKF6" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="UniProtKB/TrEMBL:Q9RKF6" /translation="MTMPAESAATVRGRRYPADPEWFCDFRTFPVQGLGPEVGVHRRD PSSVLTVDGRYHVWYTRSTGETDGFGTGDPMAKVFPWDWSEIWHATSDDGATWVEQGR ALGRGEPGSYDDRSVFTPEVLEHQGWFYLVYQVIRSPYALRSFESIAMAKAPSPDGPW VRSPQPILRPQADGEWAGEEDNRLSVVSQGSFDSHKVHDPILVPFQGRFFLYYKGEQM GEGFSAGGRTTRWGLAIADDIEGPYHRCPANPVTNSGHETCVWRYGDGIAAMLTTDGP ERNTIQFAPDGINFEIMAHIANPPVATGPLRLPDHAVAPLDGVRWGLCHDVTASWHYI QGFAADERQKMFYTRGLSPETAESAEADALPAPHEK" regulatory complement(14259..14262) /regulatory_class="ribosome_binding_site" gene complement(14276..15157) /gene="SCO3482" /gene_synonym="SCE65.18c" CDS complement(14276..15157) /gene="SCO3482" /gene_synonym="SCE65.18c" /note="SCE65.18c, possible sugar-permease, len: 293 aa; similar to TR:P72399 (EMBL:Y07706) Streptomyces coelicolor putative maltose permease MalG, 302 aa; fasta scores: opt: 491 z-score: 561.6 E(): 6.6e-24; 28.2% identity in 301 aa overlap. Contains match to Pfam entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Contains possible N-terminal region signal peptide sequence" /codon_start=1 /transl_table=11 /product="putative sugar-permease" /protein_id="CAB61806.1" /db_xref="GOA:Q9RKF5" /db_xref="InterPro:IPR000515" /db_xref="UniProtKB/TrEMBL:Q9RKF5" /translation="MTTPVHSALRAGTATPAADRITRKQRRESAAGWAKTAVMSVVTL VALAPIIMILVLSVRSGQTASGTYSWNFSNYVEIFSKTPVLDYLYNSLAVTLGTTVFA VVIGALAGYPMSRLRNRFIGGYTLSLFVVQSLPVIVFVIPLFVVFAKIGMADTLSGVA VIFIAGGMAVTCWMMAAYYDSIPVELEEAAWVDGASLWGGFVRVVLRNSYPGILSAAI FSFLVAWNDYLVATVFLRSQSNFTLPIGLQTYFQQNATDWGPVMAMSVVMLLPPVIVF AVLNRFFSIGGIGGAIK" misc_feature complement(14402..14626) /gene="SCO3482" /gene_synonym="SCE65.18c" /note="Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 52.20, E-value 1.2e-11" misc_feature complement(14537..14623) /gene="SCO3482" /gene_synonym="SCE65.18c" /note="PS00402 Binding-protein-dependent transport systems inner membrane comp sign." regulatory complement(15167..15170) /regulatory_class="ribosome_binding_site" gene complement(15169..16116) /gene="SCO3483" /gene_synonym="SCE65.19c" CDS complement(15169..16116) /gene="SCO3483" /gene_synonym="SCE65.19c" /note="SCE65.19c, probable integral membrane transport protein, len: 315 aa; similar to TR:O50452 (EMBL:AL021006) Mycobacterium tuberculosis probable sugar transport protein MTV006.08, 307 aa; fasta scores: opt: 542 z-score: 668.9 E(): 7e-30; 32.6% identity in 288 aa overlap. Contains match to Pfam entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and possible N-terminal region signal peptide sequence" /codon_start=1 /transl_table=11 /product="putative integral membrane transport protein" /protein_id="CAB61807.1" /db_xref="GOA:Q9RKF4" /db_xref="InterPro:IPR000515" /db_xref="UniProtKB/TrEMBL:Q9RKF4" /translation="MTDVSVPTRSAARTDRPRGRERKAESRHPGSKKTMAAMLAPSIF LLIALNAYPLFYAVSQSLRDGGIAGPGEFIGLENYTTALQDPAFWEAVRFTLLFTVVS VFVAWVIGTALALVLRRSFPGRSVFRVLLLLPWVVPVVVSTTSWNFLVATPSSPVPTL LRELGFGDVQILANPGSAMAIVIIFKIWGTVPFMMMMMSSALQAVDPSVEEACRLDGA SRWQRIRHVILPIMSKPVYIAWVLASIFTINDFPSVFLLTGGGPVGSTSTLVVFAYRL VFQDFRTGYGVAVAFLITTALIAMSIYFFRRINRASANG" misc_feature complement(15283..15516) /gene="SCO3483" /gene_synonym="SCE65.19c" /note="Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 60.80, E-value 3e-14" gene complement(16152..17462) /gene="SCO3484" /gene_synonym="SCE65.20c" CDS complement(16152..17462) /gene="SCO3484" /gene_synonym="SCE65.20c" /note="SCE65.20c, possible secreted sugar-binding protein, len: 436 aa; similar to TR:P72397 (EMBL:Y07706) Streptomyces coelicolor putative maltose-binding protein MalE, 423 aa; fasta scores: opt: 361 z-score: 398.4 E(): 8.1e-15; 26.2% identity in 409 aa overlapand to TR:O87856 (EMBL:AL031013) Streptomyces coelicolor putative secreted sugar binding protein SC8A6.22, 438 aa; fasta scores: opt: 344 z-score: 379.6 E(): 9e-14; 23.6% identity in 365 aa overlap. Contains match to Pfam entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein and match to Prosite entry correctly situated PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains possible N-terminal signal peptide sequence" /codon_start=1 /transl_table=11 /product="putative secreted sugar-binding protein" /protein_id="CAB61808.1" /db_xref="GOA:Q9RKF3" /db_xref="InterPro:IPR006059" /db_xref="InterPro:IPR006311" /db_xref="UniProtKB/TrEMBL:Q9RKF3" /translation="MTKPVVPSGVSRRGFLGGSLGVAGAVLLAACSGGGNSSQGSGGS KFAFWDMPWGSPGPDYLAAGKEISAAFSGGSATYQSISWDGWLQTFSSAIAAGTGPAI STGGAFQSLQYYVQDAVHPADGVIAKLRSKGQLDDFLPGTLDVFKYKGAYTALPWNVD SRLLWYRKSLLEKAGVEEPRSWDDLYRVGVALKKNDVYGMVASGGAGGNAYQTFLSFV FNNGGGLFDKDGEPQCVTDANVEAVEFLMKLAKDGIMDPGSVSYTVANLNDQFSSGAA ALSILPPDIANSFEDPRLKADITLGSPLTSPNGTKGTMAYTSDLILYTGDWDTDVVED FAVYYLDAMSAYWKKGVLNKVPVRQSILDLPEVQAQPNLVKATKEWLPVGKSLTQLAG EPFPEINAVDGGQAITQWAQQVIQAKSSGEQTLRTLQDGIEKVM" misc_feature complement(16161..17018) /gene="SCO3484" /gene_synonym="SCE65.20c" /note="Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 71.70, E-value 1.6e-17" misc_feature complement(17370..17402) /gene="SCO3484" /gene_synonym="SCE65.20c" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site" regulatory complement(17470..17473) /regulatory_class="ribosome_binding_site" stem_loop complement(17571..17618) gene complement(17644..18693) /gene="SCO3485" /gene_synonym="SCE65.21c" CDS complement(17644..18693) /gene="SCO3485" /gene_synonym="SCE65.21c" /note="SCE65.21c, probable lacI-family transcriptional regulator, len: 349 aa; similar to TR:AAD42741 (EMBL:AF105219) Thermomonospora curvata putative regulatory protein AglR, 347 aa; fasta scores: opt: 563 z-score: 648.1 E(): 1e-28; 34.9% identity in 341 aa overlap and to SW:CYTR_ECOLI (EMBL:X03683) Escherichia coli, transcriptional repressor CytR 341 aa; fasta scores: opt: 552 z-score: 635.6 E(): 5e-28; 30.5% identity in 347 aa overlap. Contains matches to Pfam entries PF00356 lacI, Bacterial regulatory proteins, lacI family PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI. Contains probable helix-turn-helix motif at residues 18..39 (+4.84 SD)" /codon_start=1 /transl_table=11 /product="putative lacI-family transcriptional regulator" /protein_id="CAB61809.1" /db_xref="GOA:Q9RKF2" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="UniProtKB/TrEMBL:Q9RKF2" /translation="MTSEAGAGQAKALPARARLVDVAKRAGVTKSVVSRILNDDTTLR IRPETRERVLAVAAELGYRPNVTARALSVSRTRAFALLIPDLSNSVYAAVTRGAFRRA RDHGYVLLIAEDAAGDDDAAYAELVTAGRVDGLLVASSRPEHPLVERLLADRGGLAHV FLNREVQGSNRNVGMDMQGASALVVDHLHDRGHRHIGMVTGPLDLAPARSRLDGFQGR LRELGLDDTAHFAGTFSEAGGCAAAHGLLDARPELTALYASTFPQAVGVMKAVRDRGW KVPADVSLIAYDDLPMAEFLDPPLTTLAMPLATLGAAAVDALVDQIEGRVIGSRQVLG GYEIVERASVAVPRV" misc_feature complement(17752..18471) /gene="SCO3485" /gene_synonym="SCE65.21c" /note="Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family., score 68.80, E-value 1.2e-16" misc_feature complement(18568..18651) /gene="SCO3485" /gene_synonym="SCE65.21c" /note="Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 27.20, E-value 3.9e-06" regulatory complement(18702..18705) /regulatory_class="ribosome_binding_site" regulatory 18844..18848 /regulatory_class="ribosome_binding_site" gene 18855..20333 /gene="SCO3486" /gene_synonym="SCE65.22" CDS 18855..20333 /gene="SCO3486" /gene_synonym="SCE65.22" /note="SCE65.22, probable aldehyde dehydrogenase, len: 492 aa; similar to SW:ALDA_ECOLI (EBML:M64541) Escherichia coli aldehyde dehydrogenase A (EC 1.2.1.22) aldA, 478 aa; fasta scores: opt: 1189 z-score: 1347.0 E(): 0; 39.1% identity in 473 aa overlap and to Streptomyces coelicolor SCI35.34c, 483 aa; fasta scores: opt: 1014 z-score: 940.7 E(): 0; 40.2% identity in 455 aa overlap. Contains match to Pfam entry PF00171 aldedh, Aldehyde dehydrogenase and two matches to Prosite entries PS00687 Aldehyde dehydrogenases glutamic acid active site PS00070 Aldehyde dehydrogenases cysteine active site" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="CAB61810.1" /db_xref="GOA:Q9RKF1" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR016163" /db_xref="InterPro:IPR029510" /db_xref="UniProtKB/TrEMBL:Q9RKF1" /translation="MTHELFDSKGLLGSAPAAFVAGEYELDSSHGTLPVINPANGQLV AEVPSSSSSTVDRAVTAAVAAQREWGRRSHVARAAVLEAVRDAIAVHADELARIVSVE QGKPLSDARGETEGACAFFDFAISQKYRAVGSMMASEPGRSLGVREEPIGVVAAILPW NFPVAIFARKVAPALMAGNAVVLKPSELTPLSALALARLCRLAGVPDGLLSVVCGEGK DTGRALVTHPGVGMVTMTGSTRGGREILAQVADQIIPVSLELGGKAPFIVFEDADLDA AVEAAADARLWNTGQVCTCNEVTYVHADLHDEFVRRVVDRFASVTPLDPFAAGSRLGP LVAERERTRVQGMVDAAVAAGARVRTGGGRPDGEQYQSGAWFAPTVLTNVRPEMDIAR REVFGPVLPIIPFDAEAEVVSAANSTAYGLTAYVYTRDLSRAMRMIDALEFGEVYVNQ AGPEQVQGFHTGWKSSGLGGDDGPHGYEKYLRRKTVYVRHAV" misc_feature 18921..20324 /gene="SCO3486" /gene_synonym="SCE65.22" /note="Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase, score 617.50, E-value 7.6e-182" misc_feature 19626..19649 /gene="SCO3486" /gene_synonym="SCE65.22" /note="PS00687 Aldehyde dehydrogenases glutamic acid active site" misc_feature 19710..19745 /gene="SCO3486" /gene_synonym="SCE65.22" /note="PS00070 Aldehyde dehydrogenases cysteine active site" regulatory 20706..20710 /regulatory_class="ribosome_binding_site" gene 20716..23112 /gene="SCO3487" /gene_synonym="SCE65.23" CDS 20716..23112 /gene="SCO3487" /gene_synonym="SCE65.23" /note="SCE65.23, possible hydrolase, len: 798 aa; similar to SW:AGAB_VIBS7 (EMBL:D21202) Vibrio sp. (strain JT0107) beta-agarase B (EC 3.2.1.81) AgaB, 955 aa; fasta socres: opt: 1394 z-score: 1581.4 E(): 0; 39.0% identity in 772 aa overlap. Contains possible hydrophobic membrane spanning region and Leucine TTA codon, possible target for bldA regulation" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="CAB61811.1" /db_xref="GOA:Q9RKF0" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013781" /db_xref="InterPro:IPR017853" /db_xref="UniProtKB/TrEMBL:Q9RKF0" /translation="MTVHKRACTTPPPRASRSFRVRWPVLIAAACAGLVLATTSPPAV AAGAHDLGDETMLYDFQDGLVPAEVGPYQAKTTIVGRGDKKLRVDFQARKNYYSSFSV RPEPVWNWSAEESESLGIAMELTNPSDRSVQLTIDLESSTGVATRSVNVPAGGGGTYY FDVDSPALHRDTGLRADPSWLADKDVTSAVWMWGSKETDTSRISQLNFYVAGLLHDRS VIVDDIRVVRDAPADPDYLKGLVDAFGQNNKVDYKGKVSRTSEILRQRAAEAKDLRRH PVPEDRSRYGGWLNGPRLEATGNFRVEKYQGRWTLVDPDGYLFFSTGIDNARMFDSPT TTGYDFDHDAIQELPPPSLTAGGPEDLNRVQKSALPTRTKMSETRADLFSKLPKYRTR AGEGFGYAPDTLAGPVAQGETYSFYKANVARKYPGSNYMERWRDNTVDRMLSWGFTSF GNWTDPEMYDNDRIPYFAHGWIKGDFKTVSTGQDYWGPMPDPFDPAFSDAAARTARAV ADEVADSPLAIGVFMDNELSWGNAGSFSTRYGVVIDTMSRDAAESPTKSAFSDELEEK YGTIDALNAAWQTTVPSWEALRSGSADLGSDETAKESDYSALMTLYATQYFKTVDAEL DKVMPDHLYAGSRFASWGRTPEVVEAASKYVDIMSYNEYREGLHPSEWAFLEELDKPS LIGEFHMGTTTTGQPHPGLVSAGTQAERARMYAEYMEQLIDNPYMVGGHWFQYADSPV TGRALDGENYNIGFVSVTDRPYPEIVAAARDVNQRLYDRRYGNLATAEGHYTGRRSAE " gene 20815..20817 /gene="none" misc_feature 20815..20817 /gene="none" /note="Leucine TTA codon. Possible target for bldA regulation" ORIGIN 1 cctcggtcgg atctttctgt cgcaagatcg ttcctaccag ggaccttacg cctgcccgga 61 cttgggggat accgcggacc gcgcgacgcg cctcccgctc acggacggtg gccgacggtt 121 actgggaaca gctcactgga cttgaaatct tccgttccgt gaggtgctga cctacacggc 181 ctgatacgtc ctgacccagc ggtagtagat gttgttgatg ctggggtctg cgagttccgc 241 gtccgtgggt tcgatacctc ggtcgacgcg ccactgatga ctctcggtgt tgaggatcag 301 atgcattggc tggtcgaaga accggctccg ggggtccctg aggtcgttcg accggttcag 361 ccggcgcacc aacctgccgt tgaagtagaa atcgaattcg gtggcgctta tccagtgcac 421 gccgtagcgg tggaatccat tccgaagaag aggttgcccg gcgccgtccc caaacacctg 481 cccagtctca ccattgtacc cgtagctccc atctgcgaaa taccccttct ggcttctcgc 541 cagttcagtg aaggggttcc gctggaatat gtggtaggcg gtgttcatgt gctttccgtg 601 caatgactcg ttgccgtagc attcgatcac gtcaatctcg ttgacgtcgt ctctgctcag 661 gagccagaaa ttcgatgaga gcttcagccc gctcacacgc atgagtactt cggtatagag 721 agggtactcg actggggtgc gggaggtcac gtagccgcag tagaccctcc cgtccggcgc 781 cctgcggccc tcgacgatga gatttccgtc agccacccag gaatggcgcg cactgtagag 841 gctgttggcc gggcccgacc agccatcctt gtgctggtcc agccatctgc ccctgaaggt 901 ttgaggcttg ccggtgtagt tgaagtcgtc cgaatggctg gggagaagct gccaggacct 961 gtttccgcca ggggcggccg gcacggggta ctgttcccat tcgaggtctg cggcatgagc 1021 ggcgggtgcg ggacccgcga gccccgcacc cgctccgagt gcgacggcac tccacttgat 1081 gagatcacgt cggttgacca cgatcgttct ccttcttcga ttcccgcctg gctgaagaat 1141 cttatatttg gcaatgactt ccgcagaccc tgggcgccaa aattcgagag ctcgcgtgcg 1201 tgcaaaaagt tccggaacgc ccacgtggca cgatcattcc acggcgcagg aggagctagg 1261 ctccaggagg taagtttctg ggctttcgct cgcctgatca ttcaatgagg tgaaccggtt 1321 tcccgaatgc tacagcggag tgtcgcaggg tgacaatcgg tacggctgca gtagttccca 1381 gaatttcgtg ccgtgcccga ctgtgatcca gcggcgacct cggtcactcg ccccgtcgcg 1441 ccggtcacga ttcatcaagc cggccttcct gtgcacggca tccccagggc ccgccgtggc 1501 aggtgaggat gccccgccga agccccgacg catcgtcccc tcgtctctgg agtccgactg 1561 aagtctctac cgaacccgta ccgaacctgg aacggttcac tccggctgat cccgagctcc 1621 cgggcggcct cggtcaccgt ccggcccgac gaccgcacga gctcgattgc gtcccgcttg 1681 tactcctcca agtaccgctt cgtgtacttg cttcccacct ggcactgctt cctctgggct 1741 ctcacatctc agtctccagg tgtccacgat cacgggaagg cttcacacga ccacctctcc 1801 cccagcgccg acacccacca cgacgactgc ccggccagag cgtgtcgtgg cctcctgcgg 1861 acgtggacag acgattcgga atgccggcag acaggagtct tcgaccggat ccaccgggtc 1921 cggagaggcg gagctgcctg ccgccggcga actcgcctgg tcgctcggca tcgggggagg 1981 tgacgacgag tacgcctggc ggtagctgat ccccgccggc accagtgccg tcagagggca 2041 aggttgggcc gccgtcggga ttccatggtc acgactggcc cgcgagcggt tcacatgctc 2101 tgtcacgtcg tcgcccgccg gggaccgctg aacatgcggc acggccacgc ctccagagca 2161 ggcagggagc caaggtctcg gcgacgcctg aattgtgacc ctctgacggc ggatcaaaag 2221 tgaccctctc ggtggtcttc gcctgaacct gatcgtgatc ggaaggtcag gagggaaggg 2281 tgatccgcgt ggaggactgg gcagagatcc gcaggctgca ccgggccgag cagatgccga 2341 tccgggcgat cgcccggcat cggggcatct cctctcttca cgatcgccct cacggctcgc 2401 ccggcgcgtt ggctgctgct cggcccagcc gcaaccgtcg catccagccg aaggcacaac 2461 caccagcgcg cgcccacgcc gcgccgcgtg gcagtgcctc ccgcacggtc agacagggtg 2521 gtcatgctct cgccgtgcgc tcggccttct ctcgggccac cgcggtgcgc aactgccgca 2581 ccctgccctc gatcgagcga gggtctccgg aagtcagttc gctgccgatt cccacagcca 2641 ccgcacccgc gcggatgtag tcgggcgcca gctcgagggg cacaccgccg gtgggaacca 2701 gggcgagctg tgggaaggga gcaagcagat gtctcacggc gtccgcaccg tagacgctcg 2761 cggggaacaa cttgacgaag tcggcgcctt cctcgatcgc cgtggcggcc tcggtggggc 2821 tcagtgcgcc cgccagggtc gccatgccgt agcgatgtgc ggctcggagg acggtgcggt 2881 tcaccgtggg agatacgacg aatcgtgcgc cggcgagctc gctcatgcgt acggtggctt 2941 cgtccaggac ggtgccgaca ccgatcagag cttcgtgcgc cggccagccg tggctcaggt 3001 ccgcgacgac atcaagggcc ccgggagtgg tcatcgacac ctccacgacg cgctgaccgg 3061 ctttcaacag ggccagtgcc tgctctcggg cgagatcagg gctatgtgag cggaccacag 3121 cgacgacccc atctcgggcg attcggctgg cagtctcgta acgcggcatg actcctccga 3181 cgacggtgtc cgtggggtgc ctggtgttca ggggtgtggg ctcgcctcgg caggggaacc 3241 gtgtccgggc cattcgttgc cgtgcttcgc ccgtgctacc agcgctgccg gggcggtagg 3301 caggtcggca acgtccgaga gcgatgtcat cgcggcaccg gccagcaggt gcccgagtcg 3361 caggcaaccg gcctcgtcaa ggcccacgag ggctccgtga atccatcctg cggcgaacgc 3421 gtcaccggca ccgacgggtt cgaccacgtc gacgggcagc gcgggcaccg cggtccgacg 3481 gcctccgcgg aaggcgacgg cctctctgcc gccgtccttc actacgacga cgtccggact 3541 cgggagatgg tcccggaccg ctcccgcggt gcaagatttc cacagggtct gcgcctcgtc 3601 gaggccgacg aaaaccacat tgcaacgatc ggcgatggcc atgagcgact gtgccgcagc 3661 gtcgcgggct ggccagaggg acgggcggta gttgacgtcg aaactgacac tcgctcccgt 3721 atcacccgcg agctcgatca gcgagatgac cgcttcacga cagttctccg acaatgccgg 3781 cgtcacaccg gtcaggtgga tccagcgggg acgcaccgca gcgatccgtt ccgcgtactc 3841 tccgtccatg agcgtggcgg ccgagccgga ccggtagtag tagatgtcgg acccttcggg 3901 cgcggggtcc ttgaagtaga cgcccgttct gcgtcccggc atcgtacgcg cgagcttcgt 3961 caccacgccg tgccgacgga gttcgccaag gacacggaga cccatcgggt cgtctccgac 4021 gaatccggcc cagaacgcgg ctgtgcccag cctcgagagg gagatcgcga cgttcgactc 4081 ggcgcccgcc accccgaagg cacaggcgga cgcctcgtga agacgaaggc cgtcgatcgg 4141 cacgatctgc gccatcgtct cgcccagaca gacgacggca ggccctcctt ccaccacagg 4201 ccgggtcatc gggcttccgc ctcgtgcatg gtcacggacg ttccgacggc tccctcgtcc 4261 ggccggcgcc cggtcttcat ggtccccatt ctgtcccgcc tgttcgaggt gtcgagtgct 4321 tcgctgtcgg cccgcgtcac cagtcaccgt gcgatccgtc ctggtgggtg aagcggggtg 4381 tggtccagtc gccggcgtag acacggtcca tgagctgtgc ttcgtcgact tcgatgccca 4441 ggcccggccc ggtgggtacg gctatgtgtc cgttctcgac cgagaacggc accgccagga 4501 tcccggcgcc gagatcggcc ccgtcgtcca gtgccagata ctcctggatc aggaaattgg 4561 gtgtgctggc ggccacttga aggcaggcgg ccagcgagac gggccccagg gggttgtgcg 4621 gagcgagcgc gacatagtgg gcctcggcca tggcggcgat ccgacggact tcgctgatcc 4681 cgccggcatg gcacaggtcg ggctggacga cggacacggc ccggcgttcg aggagttccc 4741 ggaagcccca cttggtgaag atccgttcgc cggccgcgat cggcacgttc gtcgccctgg 4801 cgatctccgc cagggcgtcg acgttctccg ggagacacgg ctcctcgatg aagagggggc 4861 ccatcggact caggcgttct gccaggcgtc gggccatggc aggtgacgtg cggccgtgga 4921 agtcgagcgc gatgtcgaag gcggggccca cagcctcgcg aaccgcagcg acgcgggcaa 4981 cctggcggtc gacgtactcc accgtgtcga gggcccttac cggtccgtcc aacccgaact 5041 tgatcgccgt cattcccgcg gaccgtgagc gccgcgcggc gtgggcgaac tccgcgtccg 5101 tgacgccccg ggcgtgcccg tacatgcgca ccgaatcacg gacagcgccg cccagcaatg 5161 cgtggacggg gactcccagg tccctggcgg tgatgtccca cagcgcctgg tcgattccac 5221 tgatcgcact gcacaggacg gctccgccgc ggtagaaggc cccacggtac attccctgcc 5281 agtggtgttc gatccgtctg gggtcgcgcc ctgcgaggta ttccgcgagg tcgccgatca 5341 tgcgctcgac gaccctcgcc tgcccttcga caacggcctc accccatccg atgacaccct 5401 tgtcggtctc caccgccacg aacagccatc tagggcgaac gtgaaaggtg cggaccttca 5461 ctattctcac tgtgaatccc ctcttggggc gatattcctc gccttttgac gacaagttgt 5521 agattccagg gcggtgcgcc cggcgggtag cccgcgtacc tgcatctgcc gctcggtgtc 5581 ctcgtcccac gcgacctccc ggccgtggcg ttggtgccgc gctccccggc acccgcgtgg 5641 acggcgcctc gactcacgtc accgaactgc ggcgcccggc gcctaacggg caagccatcc 5701 cccgtcgaca gcgaggacct ggccatgaac gtatgccgcc gcgcgggagg ccaggaaaac 5761 cgccacgtcg cccacgtcat ccgggcctcc ccatcggccg gccgggatac ggaccgagag 5821 ctgctccagc cggacggggt cctcaagcag tgccgtgttc atctctgtgg ccatgtatcc 5881 gggcgctatc gcgttgacgt tgacccctcg gcccgcccat tcattgcaca gagccttggt 5941 gagctgcgcg acggcaccct tgctcgccgc gtacgcggcc acggtgaatc cgccctgaaa 6001 gctgagcagt gatgcgaggt tgatgatctt tccctcaccg cgctggatca tgggccgccc 6061 gaagatctgg cacagctgga ccaccgagcg caggttgacg tcgagcaccg cgtcccaggc 6121 atcgagcggg aagtcctcgg cagggtgccg gatctgcgct ccggcgttgt tgaccaggat 6181 gtcgacctgg tgaccggcga gcacttcggc ccccgcggcc gccacgccct cgcggtcccg 6241 gagatcgaca ccgacgtgac tcaccgagcg tccgagatct gcggctgtcc gcctcagccg 6301 gtcatccagg gcgctccggc tgagcacgac tacatcggcg cccgcgttca acaacgcgcg 6361 gctgataccc agtccgaggc cgcgccctcc gcccgtgacg acggcggtac ggcccgtgag 6421 gtcgaatgag gagatcatgt ggcttcgtct ctgtgtgtgc tgatgagaac tttcagtccg 6481 cccgaccctg tggccgctgc gtcgaaggcg tcggaaatcc ggtcgaaccc gtagacggat 6541 accgggaacc tgtccagccc cagcgcgttc tgcgcgacca ggtcgatcgc ggtgcggaag 6601 tcttcgcgcg tgtagacccg cacgccgacc acggactgct ctttgaagca cacggcctgg 6661 aggtcgaccg cggctggttc cttgtacaca ccgacgatga ctacgcggcc gaggacacgg 6721 gtgacatcgg cgagttcggc ggccacagcg gggtgggccg cgctgtcgaa cgtcgtgtcg 6781 gctccgtcgc cctgcgagag ctccgcgacc atgtcccgca gctgtgcacc gtcagggacc 6841 gcgatcagcc ccatgtcgct cgccactgca cgacggcggg cgttcggctc ggcgaccact 6901 acgtgcgatg ccccctcgtg ccgggccacc agtgcggtga gtatgcctat cggccccgcg 6961 ccgaagacag ccaccacatc cccggcttcc atccccgagc ggctgaccgc gtgtacggcg 7021 accgccagcg gctcggtcag cgccgcctgc gtgggttcga cgcgcgacgg gacctgatgc 7081 agagtcgacg tcggcagcgc cacgaactgc gcggcgcctc ctggcgcgtc gatgccgaac 7141 agaccgagcc gggcgcacac atggctgtgg ccctcccggc acgcacggca gtctttgcag 7201 gagatcagcg gttcagcgac caccagcgca ccttccggag gcccgcccgg cgccgtgacc 7261 tcgacccagc ccgagatctc gtgaccgagg atcagtccct gtcgcgcccg cgggtgcttg 7321 ccgtgcacga tccccaggtc cgtgccacag atcccggtgc aggcgacccg gaccagcgcc 7381 catcccggcg gcacctcggg catcggcacc tcctccacgc ggacatcgtt gacgccggcc 7441 cacaccacgg cgctcatccc gcccgtcatc gccgaccctc cgaccgctgc gcagccgccg 7501 gcagcgcctc gggattcacc acgtttcggg gcgtgcgccc agcgcaggcg tcgacgacgt 7561 tctccacggt gcgcctcttg agctccgcgt aggactcctc gctgtaccag gcaagatgcg 7621 gcgtgagtac gacgttgtcg aacgacgtca gcgggtgatc ccgcgggagc ggctcgatct 7681 cgtggacatc gatgccagct cctgcgacgg cgccgcgctt gagggcgtcg acgagagcac 7741 ccgtatcgat caccccgcct cggctcgtgt tgacaacgat cgcgtcggga cgcatccgtg 7801 cgaacgcgtc ggcgcccagc agaccgcgcg tctgctccgt gaggggcgta tggacggaga 7861 cgacctgtgc ccgttcgagc agctcgtgga ggccgacgga gcgaaaaccg cggaatgtct 7921 gcgcgtccgg gtccgcggcg ctgtcgtagg cgatgacgtc atagccgagc cctgctgcct 7981 tgcgtgcggt ggccgcgccg ataaggccca tcccgacgac tccgaagact cgttggccca 8041 cttggtacag gggacgcacc gcagggaggt cgaacgagcc ggcgcgcacg ccccggtcga 8101 gccgggggat gccccgggcg acggacaggg cgagcccgat cgcgtggtcc gataccgcct 8161 ccgtgccgta gtcgggcacg ttgcacacga gaatgccgcg ccgcgtcgcc gcctccacgt 8221 ccaccgagtc gacaccgacg ccgtagcgtc cgatcacctt gaggcgtggg agacggtcca 8281 tcacctgctc cgtgatcgcc gcgtactgca ccacgatcgc gtcggcgccg gcacaattga 8341 ccaccatcgt gtcggcgtcc cgggactggg tgacgaggag ttgcccccct gcggaggtga 8401 ctacgtctcg ttctatgtcg aaggaatcat ggtcgcactc cgtgatggcc accagtgggc 8461 caccgcctgc cgttctcatg gccgtcatca ggcggatcac tctccaggct ctgtgtgatg 8521 tgtgatggtg ctcgacggaa caccgccctg gcgccccgcg tggctccctc ccaccggcga 8581 tcgctcggtt ggaaggcttc ctccgcggtg cagagcgtct gctacggctt gttcagttca 8641 ccgagcgccg tactcgcgaa cacccggtac cggcggcgac gtggtccgaa ccgcgccggc 8701 ggtggcctag gtggcggttc aggcgtcttg actgtcgtcg gcagccggct ggaccacttc 8761 gccgcagtcg aacgacccgc ccgtcttcgg ccacggctcc tacgtccgcc tgtcgaccag 8821 gtcgcgccag tcaccgcaac ccaggtagat aaaccggttt ttcaccctac atgacggtcc 8881 ttgcactgac taccgccacc cgatgcggca cgcgatgagt cctgggggtg cggcggcgcc 8941 cccgccaccc cctgcaccgc ggggaccagt tccatccggt aggccagctc gtatcgtccc 9001 ggtccgatcc ggtactccgg gaggacgtcg ggcccgcatg ccccggtccc gacccccctg 9061 tgcgccgcat ccaggcacac gaccagtcgg ccgtcctcgc gcagatcact ggcgttcccg 9121 gcggcgaaca gcgcctgagg cgcataccgc gtcgccgacc agcagaagtc accaccgagc 9181 gaggtcagcc gaaggcggtc gccgcgatcg tcgtcgatca gctcaagcca gagtgtcccg 9241 gtgcgcagcc cgaattcctg cggcacgagg tagggagagg gttccacatg cgacgaccag 9301 cggcccaaca tcgccgaccg gttccggtcc gggtagttct cgtgcgggcc ccgcccgaac 9361 cagacgaacc ggtcgaatcg ggggtccact cggaacagca cgccgacacg cggcaggtcc 9421 gccgcctcgt cgggcacctc gaaccggtga cggtaatccg caccgctctc gctcctggac 9481 acggagacgg tgtggtccac gatctcgtgc gcgggccgcg tgtccagacc ggcgtccctc 9541 cagcggataa gggtgcgtga tcccatctct ctcacacgga cgatgtgctc catcagcttg 9601 agcccatcgt tgtccgtcgc agcgcgccac acgttgggca ccgggtcgtc cgccgtctcg 9661 cccggcaccg cgacagcccc gttcaccggc gggccggggg cggttcttcc gtcccgcaga 9721 gcgagctggt cccacgcgac gggatgcccc gccggtgcga accacgactc tgttcgggtc 9781 cgccacgtaa tggtcagcag ggcttgcgcg gcgcccgcgc gcgccgcgtc cgcgggcagc 9841 ggcacggcca cgctcccacc gggcgcgatg tcggggacgt cgagcgtgcc ggaggccgac 9901 ggagcgccgt ccagaaggag ttcccagcct gccgcgaggt ctcccgtgcc ggcgaaacga 9961 cgtcggttgg tcacgtacaa cccgccgtcc acgtactcag tggtcacagg ccggtacacc 10021 caggcgactt cggccgttcc ggggtgaggc tcgacatcgg cggaaaccag gccgtccgcg 10081 acgaagttcg cgtcgtgggg cgcgtcgccg aactgcccac cgtacgcgag gcgggtggtt 10141 ccgtcgggga gccgctgtcg caggccgtgg tccttccact cccagatgaa gccgccctgg 10201 agtccgggcg tggaggtgat gacgtcccag tagtcggcca gtgagccgtt gctgttaccc 10261 atggcgtgcg agtactcgca catgatcaag gggcggtccg ccgccccggc ggccacctgc 10321 tccccgtagg cccggatctc ctcgatgccg ggatacatcg ggcagacgac gtccgtggcg 10381 tgacggcccc cgtcggtcca cccggagttc cggatggcgt cctcgtagtg gagcggacgc 10441 gagcggtcgg cgcggcggat ccaccccgcg agagcgtcgt ggttgacgcc gtacccgctc 10501 tcgttgccca gactccactg gaccacgcag ggatggttgc ggtcacgcgc caccatgcgg 10561 gccccgcgct ccagccaggt cgcgcggtac cgcgggtcgc cgcagaggta ccagttgaac 10621 gcgtgcgact cgatgttggc ctcgtcgacg acgtagaagc ccagttcgtc gcagaggtcg 10681 tagaaggcgg gatcgttcgg atagtgggat gtgcggatgg cattgatgtt catccggcgc 10741 atggccgcca ggtcggcacg catgtcctcc gcggtgaccg cggcaccggt gtcggggtgg 10801 tggtcgtgcc ggttgacccc gaagatccat acacgtcggc cgttcacgag gaagtccggc 10861 ccgtcgatct cgacgcgtcg gaaacccacg cgtacccggg tcgcgtcgac cacgtctccg 10921 gccgggtcga tgagctccgc tgcgacttcg tagagcgtcg gcgtctccgc cgaccagggg 10981 aggatccgaa gcccgtcccg gtgcagccgg gcgatgtgcc cggagaactc gtaggtgttg 11041 ttgaccgcat ggggaaccgg agcgtcctga ggccccgcca ctcccgcacc gtcgcggccc 11101 gacagcgaaa cccggacgcg atatccctcc gccgccgtgc tctcgccgaa gtcgaccgtg 11161 gcgcggacat cgagcgatcc ttcaccagag cggggatcga ggtccgcccg ggcatccagg 11221 tcgacgagtc cgacaggcgg gcgggcctcg acacgcacac cgcggtggag accggcgagc 11281 caccatccgt cctggtcctc gaggaagctg tgcgccgagt acctcacgac gaccacggca 11341 agctggttcc tccccacgcg ggccgcttcg gtcacgtcgt actcgctccc gagacgggcg 11401 tcggtgccgt atccgacgaa cacgccgttg aggtagacgg catgcacact gtcagcgcca 11461 cccacgtgca gcagcagccg ttggccctcc cagtgggacg ggacgtcgaa gcccgtgcgg 11521 tacacacctg tggggttgcg cgacgggagc cgcggcggag gctcggcgaa cggcatctgg 11581 atgttcgtgt agtgcggaat gtcgtcggcc acctggaccg gccagctacc gggcacgtcg 11641 accgattgcc attgcccggg cgcccgctct cctctcacgg catcggcagg cacctggtcg 11701 ggagagggga acagccggaa ggaccaggtg ccgtccagcg acagccggcg gtccccctcg 11761 gcggcgggac gcgcgcgcat cgggagtcgg agcagggatg tcatcgtagg gtccgcccac 11821 gggcggagag caccgatgat ggggagcacg tcgattcctt acgtcatggg acgtcacggg 11881 gggggaggag gcggccggtc ccggccaccg cccgctcatc gtcataccgg ccgtgggtcg 11941 gtgatccgcc gacggtgccg actgggtcag ccgcaggccg ggcgaccggt caccccaccg 12001 ccagccggcc gaggcgctcg aagtccagca ccacgccgtg cccggggcgg tcgggagcgg 12061 agacgcatcc gtccgtgacg gccatcggct cggccatgta ggcgtgcagg ccgaagccgt 12121 gtgcctccat gtaggtccgg tgggggaccg aggcgagcgc atgcaccgtg aggtcgtgca 12181 cgccgtgcga cgtcagcagc atgttgttcg cctccgccag tgcggcgacc ttcctgaacg 12241 tcgtgtaccc gccgatgttg ctgacgtccg gctcgggaag cgtcagggag ccggcgcgga 12301 cagcgttgtg gaagtcgtac agggtgtgga ggttttcgcc gcccgcgatg gtgtgaccgc 12361 tttcccgaac gatccgggcg ttgccgacga ggtcgtcggg aatcgtcggc tcctcgatcc 12421 agtgcaggtc gaagggcgcg agcgcccgag ccgcgcggat cgcgccgtcg accgtccact 12481 tcatgttggc gtcgaccatc agcgggaagg agtcgccgag gtgctcacgc aacgccgaca 12541 cccggtcgac gtcctccttg aggtccgggc ggcccacctt catcttgatg gcccggaatc 12601 ccccggccag gaaacggtcc gcctgcgtct tcagatcggc gaccggcagt tccaggtcga 12661 tgccgccggc atacacgggc acgacagggt cgtacccccc gaacagcttc cacagcggcg 12721 tccgtgcccg gattcccttc aggtcccaca gggcgatgtc gacggccgag atcgccgatg 12781 tggcgtgccc cccgcggccg gcgtagtgca gccgccacca catcgactgc catatcttct 12841 cgatctgctc ggcgtcggca ccgagcaggc agcccctcag gtccttgtcc accatcgtcg 12901 ccacggccgc cccaccatgg ttgaccgtgt aggtgtagcc cagacctgtc gccccgtcgc 12961 tgtcctcgat ccgcacggtg atgagctcga aatccatcat ggcgccgtgc gtcgagtcgg 13021 tgagcctggt cgggagcggt atgcgataga gatcggtgcg tacccgttcg atcatgcctt 13081 gtaccgtttc tctctgaggt gtgcgtctga cccggcctca cggcagggag ctgaggtcac 13141 ttttcgtgcg gagcgggaag cgcgtcggcc tctgccgatt ccgccgtctc ggggctcagg 13201 ccgcgggtgt agaacatctt ctgtctctcg tcggccgcga acccctggat gtagtgccac 13261 gatgccgtga cgtcgtggca cagtccccag cgaaccccgt ccagtggcgc gacggcgtgg 13321 tcggggagcc tgaggggacc ggtcgcgacg ggtgggttcg cgatgtgggc catgatctcg 13381 aagttgatcc cgtcgggcgc gaactggatc gtgttgcgtt ccggtccgtc ggtggtgagc 13441 atcgcggcga tgccgtcgcc gtatcgccag acgcaggtct cgtgtccgct gttcgtcacg 13501 gggttggccg gacatcggtg gtacggtccc tcgatgtcgt cggcgatcgc caggccccac 13561 cgggtcgtgc gtccgccggc ggagaaccct tcccccatct gctcgccctt gtagtagagg 13621 aagaatctgc cttggaacgg gacaaggatc gggtcgtgca ccttgtggct gtcgaaggac 13681 ccctgggaga cgacgctcag ccggttgtcc tcctctcccg cccactcacc gtccgcctgg 13741 ggtcggagaa tcggctgggg ggacctgacc cacggaccgt ccgggctcgg tgccttcgcc 13801 atcgcgatcg actcgaagct ccgtagcgcg tagggcgacc ggatcacctg gtagacgagg 13861 tagaaccagc cttggtgctc caggacctcc ggggtgaaca cgctccggtc gtcgtagctg 13921 cctggctcgc ccctgccgag ggcacgcccc tgctcgaccc aggtggcgcc gtcgtcggac 13981 gtcgcatgcc agatctcgga ccagtcccag ggaaagacct tggccatcgg gtcgccggtt 14041 ccgaagccgt cggtctcccc ggtcgagcgg gtgtaccaga cgtggtaccg cccgtcgacc 14101 gtgaggacgg agctcgggtc ccggcggtgt acgcctacct ctggaccgag tccctggaca 14161 gggaaggtcc ggaagtcgca gaaccactcg ggatcagccg ggtaccgcct gcctcgaacg 14221 gtcgccgcgc tctctgcggg catggtcatg cgctcgtact cctcatgggg ggtggtcact 14281 tgatcgctcc gccgatccct ccgatggaga agaagcggtt gagcacggcg aacacgatca 14341 ccggcggcag cagcatgacg accgacatcg ccatcacggg cccccagtcg gtggcgttct 14401 gctggaagta ggtctggagc ccgatcggca gcgtgaagtt gctctgcgac ctcaggaaga 14461 cggtggcgac caggtagtcg ttccacgcga cgaggaagct gaagatcgcc gccgagagaa 14521 tgcccgggta cgagttgcgc agcaccacac ggacgaatcc tccccacagg gaggccccgt 14581 cgacccaggc ggcctcctcc agctcgacgg ggatggagtc gtagtaggca gccatcatcc 14641 agcacgtgac ggccatgccg ccggcgatga agatgacggc cacaccgctg agcgtgtccg 14701 ccattccgat cttcgcgaag acaacgaaga gcgggatgac gaagacgatg acgggcaggc 14761 tctggacgac gaagagcgag agcgtgtagc cgccgatgaa cctgttgcgc agtctcgaca 14821 tcggatagcc cgccagcgcc ccgatcacga ccgcgaacac ggtcgtcccc agggtgacgg 14881 caaggctgtt gtagaggtag tcgaggacag gagtcttgga gaagatctcg acgtagttcg 14941 agaagttcca cgagtacgtc ccggaggcgg tctgtcccga gcggaccgac aggaccagga 15001 tcatgatgat gggtgccagg gccacgagtg tgacgacgga catgaccgct gtcttggccc 15061 acccggcagc ggattcccgc cgctgcttgc gcgtgatgcg gtcggcggcg ggggtggctg 15121 tgccggcccg gagggcggaa tgtactggag tggtcatctg taccgccctc agccgttcgc 15181 cgacgcacgg ttgatgcgac ggaagaagta gatggacatg gcgatcaggg cggtggtgat 15241 gaggaaggcg accgcgacgc cgtaaccggt gcggaagtcc tggaacacga gccggtaggc 15301 gaacacgacc agcgtcgagg tcgacccgac gggtcctccc ccggtcagca ggaagacgga 15361 ggggaagtcg ttgatcgtga agatcgaggc gagtacccac gcgatgtaga cgggcttcga 15421 catgatcggc aggatgacgt gccggatgcg ttgccaacga ctggccccgt cgagccggca 15481 ggcttcctcg acactggggt ccaccgcctg cagcgcggaa ctcatcatca tcatcatgaa 15541 ggggaccgtc ccccagatct tgaagatgat cacgatcgcc atcgccgaac cggggttggc 15601 caggatctgg acgtcaccga acccgagctc acgcaggagc gtgggcaccg ggctggacgg 15661 cgtcgcgacc aggaagttcc agctcgtcgt gctgacaacc accgggacca cccagggcag 15721 caggagcagc acccggaaca ccgatctgcc ggggaaggac cggcgcagca cgagagcgag 15781 ggctgtgccg atgacccagg ccacgaagac cgagaccacc gtgaacagga gggtgaagcg 15841 cacggcttcc cagaacgcgg ggtcctgcaa ggcggtcgtg tagttctcca ggccgatgaa 15901 ctccccgggc cccgcgatcc caccgtcacg cagcgactgg gaaaccgcgt agaagagcgg 15961 ataggcgttg agagcgatga gcaggaagat cgacggggcg agcatcgccg ccatcgtctt 16021 cttgctcccg gggtgccggc tctcggcctt cctctctcgg ccccgaggcc tgtccgtcct 16081 cgccgccgat ctcgtcggca ccgacacgtc cgtcatggac gcctccttct gtgcgtcaga 16141 tgacccgtgg gtcacatgac cttctcgatg ccgtcctgca gggtccgaag ggtctgctcg 16201 ccactgctct ttgcctggat gacctgctgg gcccactggg tgatggcctg tcccccgtcg 16261 accgcgttga tctcggggaa gggctcaccg gcgagctggg tgagggactt gcccacgggc 16321 agccactcct tggtcgcctt gaccaggttg ggctgcgcct gcacctcggg caggtcgagg 16381 atgctctggc gcaccgggac cttgttgagg acgcccttct tccagtacgc cgacatggcg 16441 tcgaggtagt agaccgcgaa gtcctcgacc acgtccgtgt cccagtcacc ggtgtagagg 16501 atcaggtccg acgtgtacgc catggtgccc ttggtaccgt tcgggctggt cagggggctt 16561 cccaacgtga tgtcggcctt gagccgcggg tcttcgaagg aattggcgat gtccggtggc 16621 aggatcgaca acgccgcggc gcccgaggag aactggtcgt tcaggttcgc caccgtgtag 16681 ctcacgctgc ccgggtccat gattccgtcc ttggccagct tcatgaggaa ctccacggcc 16741 tccacgttcg cgtccgtcac gcactgcggc tcgccgtcct tgtcgaacag gccgccaccg 16801 ttgttgaaca cgaacgacag gaacgtctgg taggcgttgc ccccggcacc gcccgaggcg 16861 accatgccgt acacgtcgtt cttcttcagc gccacaccaa cccggtacag gtcgtcccag 16921 ctgcgcggct cctccacacc ggccttctcc agcagcgact tgcggtacca gagcagccgc 16981 gagtccacgt tccacggcag tgcggtgtac gcgcccttgt acttgaacac atcgagcgtg 17041 cccggcagga agtcgtccag ctgccccttg gacctcagct tcgcgatgac cccgtcggcc 17101 ggatggaccg cgtcctggac gtagtactgc aacgactgga acgccccgcc cgtggatatg 17161 gccggcccgg tcccagcggc gatggccgag ctgaaggtct gaagccaccc gtcccagctg 17221 atcgactggt atgtcgccga gccacccgag aacgctgcgg agatctcctt gcccgcggcg 17281 aggtagtccg gcccggggga cccccagggc atgtcccaga acgcgaactt cgagccaccg 17341 gagccttggg acgagtttcc gccaccagag cacgcggcca acagcaccgc ccctgccaca 17401 cctagtgagc cgcccaggaa tccccgtcgg gacacaccgc tgggcacaac aggcttggtc 17461 atcgaacatc tccctcgagc gtcgttgcat cgggatgttc ccccactgga gaaccggttt 17521 tccaccgtag cgtggcggcc cgtaccccac aaccctcgat ctcgtacacg tcgacgggcg 17581 gctgtctccc gggtccgcgg gagacagccg cccgtcgatc agctcacgac cgcctcgagg 17641 tcgtcagact cgcggaacgg cgaccgaggc ccgctccacg atctcgtacc cccccagcac 17701 ctgacggctg ccgatcacac ggccctctat ctggtcgacg agagcgtcga cggccgcggc 17761 tcccagcgtc gccagcggca tggcgagcgt ggtgagggga ggatcgagga actccgccat 17821 ggggaggtcg tcgtacgcga tcagcgacac gtcggcgggc accttccacc ctcggtcacg 17881 caccgccttc atcaccccga cggcctgcgg gaacgtgctg gcgtacagcg cggtcagctc 17941 cggccgcgcg tcaagcagtc catgtgccgc cgcgcatccg ccggcctcgc tgaaggttcc 18001 ggcgaagtgg gcggtgtcgt ccaggcccag ctcgcgcagc ctgccctgaa acccgtccag 18061 ccgggaccgg gccggagcga ggtccagggg acccgtcacc attccgatat gccgatgccc 18121 cctgtcatga aggtggtcga cgaccagggc gctcgccccc tgcatatcca tgccgacgtt 18181 acggttggac ccctggacct cccggttgag aaagacgtgc gccagcccac cgcgatcggc 18241 gaggaggcgc tcgaccaggg ggtgctccgg ccgggacgac gcgacgagga gaccgtccac 18301 ccgcccggcc gtcaccagct ccgcataggc cgcgtcgtcg tcccctgctg cgtcctcggc 18361 gatgagcagc acgtagccgt ggtcacgcgc cctgcggaag gctccgcggg tgaccgcggc 18421 gtacacggag ttcgacagat cagggatgag cagcgcgaac gccctggtcc gcgacaccga 18481 cagcgcgcgc gccgtgacgt tgggccgata cccgagttcc gcggcgacag cgaggacgcg 18541 ctcacgcgtc tcgggcctga tccggagcgt ggtgtcgtcg ttcaggatcc gtgagacaac 18601 ggacttggtc acccccgcgc gcttcgccac gtcgacgagc cgcgctcgcg ccggaagcgc 18661 tttcgcctga cccgcccctg cctccgatgt cattccgtgc ccctctccca ccgccgctgc 18721 cacgaacatc ttgcctggca gaggatcgtg gcgtgctccg atgcccgttg tcgaccaggc 18781 gtgtcaccgt atggtaaacc ggttatctgt gacgcgcgga cgtgattcag gcgtcctcgg 18841 cgggaaggaa cgacgtgact cacgaactct tcgacagcaa agggctgctg ggcagcgcac 18901 cggcggcctt cgtcgccggt gaatacgagc tcgactcctc gcacggcacg ctcccggtga 18961 tcaatcccgc caacgggcaa ctcgtcgccg aggtgcccag cagctcttcc tcgacggtgg 19021 accgggccgt gacggcggcg gtggccgcgc agcgcgagtg ggggcgccgc agtcacgtcg 19081 cgcgcgcggc cgtgctggag gctgtgcgcg acgcgatcgc ggtgcacgcc gatgagctgg 19141 cgcggatcgt ctcggtggag cagggcaagc ctctctccga cgcccgtggc gagacggagg 19201 gcgcgtgcgc cttcttcgac ttcgcgatca gccagaagta ccgggccgtg ggctccatga 19261 tggcgagtga gccgggccgg tcgctcggcg tgcgtgagga acctattggc gtggtggcgg 19321 cgatccttcc ctggaacttc ccggtcgcca tcttcgcccg caaggtcgct cccgcgctca 19381 tggccggcaa cgccgtcgtt ctgaagccgt cggagctcac tcccctctcc gcgctcgctc 19441 tggcccggct ctgccggctg gccggggtgc ctgacgggct gctgagcgtc gtgtgcggag 19501 agggcaagga caccggacgg gccctcgtca cccatccagg cgtcgggatg gtcaccatga 19561 cgggctcgac acgcggcggc cgggagattc tggcccaggt ggccgaccag atcatccccg 19621 tctccctcga gctcggcggg aaggctccgt tcatcgtctt cgaggacgcg gacctggacg 19681 ccgcggtcga ggccgctgcc gacgcacggc tctggaacac gggacaggtc tgtacgtgca 19741 acgaggtgac ctatgtgcac gccgatctgc acgacgagtt cgtgcgccgt gtggtcgacc 19801 ggttcgcctc ggtgaccccg ctcgatccgt tcgcggccgg ctcgcgactg ggcccgctcg 19861 tggcggagcg ggaacggacc agggtccagg ggatggttga cgcggccgtc gcggccggtg 19921 cccgcgtccg gaccggaggc ggccgtcccg acggggagca gtaccagtcc ggcgcgtggt 19981 tcgcacccac ggtgctcacg aacgtgcgtc ccgagatgga catcgcgcgg cgggaggttt 20041 tcgggccggt cctgcccatc attccgttcg acgccgaggc cgaggtggtc tccgcggcca 20101 attcgaccgc ctacggtctg accgcctacg tctacacccg agacctctcc cgggcgatgc 20161 gcatgatcga cgccctggaa ttcggggagg tctacgtcaa ccaggccggg cccgaacagg 20221 tgcagggctt ccacacgggc tggaaaagct ccggcctcgg aggcgacgac ggcccgcacg 20281 gctatgagaa gtacctccgg cgcaagaccg tgtacgtgcg gcacgctgtc tgacggcgag 20341 gccccgccgg gggacgtcct acccacccgg cccacccaac ccgcccggcg ctcgggtgcg 20401 gccccggcgg agcgtccggg cccctccggg cggggctcat cttgtcgtcg cagccgtgtg 20461 gacagggcgt tgttccaccc gccccgatgc tcgccctgcc ctccaccgag ccgtcaaccc 20521 ttctctgagc tgcgcttatg tcccgtcaca tggttgaacg cagcacagga cgcaatctgg 20581 tgcagatact tgccccgcat aaaaaaaccg gtttaccatc gggccgcgcc ccttcggtca 20641 cggtagatcg aggcgcagcg tgcgcagaga ccgtgcgagc cggtcctctg cgcaccttcc 20701 cagatggagg gaagcatgac cgtgcacaag cgcgcttgca ccactccgcc gccgcgagcc 20761 agcaggtcgt tccgcgtgag gtggcctgtc ctgatagcgg ccgcctgcgc cgggttagtc 20821 ctggcgacca ccagccctcc ggccgtcgcg gccggcgctc atgacctcgg cgacgagacc 20881 atgctctacg acttccagga cggcctggta ccggccgagg tcggcccgta ccaggcgaag 20941 acgacaatcg tcggtcgcgg cgacaagaag ctccgggtcg atttccaggc ccggaagaac 21001 tactactcct cgttctccgt acgccccgag cccgtgtgga actggtcggc ggaggagtcc 21061 gagtcgctcg gcatcgcgat ggagctcacg aacccgagcg accgctccgt ccagctcacg 21121 atcgatctgg agagctcgac cggcgtcgcc acccgcagtg tcaacgtccc ggccggcggc 21181 ggtggcacgt actacttcga cgtcgacagc cccgcgctcc accgcgacac cgggctgcgc 21241 gccgatccgt cctggctcgc ggacaaggac gtcacctctg cggtctggat gtggggctcc 21301 aaggagacgg acacgagccg catcagccag ctgaacttct acgtcgccgg cctgctgcac 21361 gaccggtcgg tcatcgtgga cgacatccgc gtcgtccgtg acgcgccggc agaccccgat 21421 tacctcaagg gcctggtcga cgccttcggt cagaacaaca aggtcgacta caagggaaag 21481 gtctccagga cgtcggagat tcttcggcag cgcgctgccg aagccaagga ccttcgcagg 21541 catccggttc cggaggaccg gtccaggtac ggcggctggc tgaacggtcc acgactcgag 21601 gcgacgggca acttccgcgt ggagaagtac caggggcggt ggaccctggt ggaccctgac 21661 ggctacctgt tcttctcaac cggcatcgac aacgcccgca tgttcgactc cccaaccacg 21721 acgggttacg acttcgacca tgacgcgatc caggagctgc cgccccccag cctgacggcc 21781 ggcggccccg aggacctcaa ccgcgtccag aagtcggcgc tgccgacccg cacgaagatg 21841 tccgaaaccc gcgccgacct cttcagcaag ttgcccaagt accgcacccg cgcgggcgag 21901 ggcttcggtt acgcccccga caccctggcc ggtcccgtcg cgcagggcga gacctacagc 21961 ttctacaagg cgaacgtcgc ccggaagtac cccggcagca actacatgga gcggtggcgg 22021 gacaacacgg tcgaccggat gctcagctgg ggcttcacct ccttcggcaa ctggaccgac 22081 ccggagatgt acgacaacga ccgtatcccg tacttcgccc acggctggat caagggcgac 22141 ttcaagacgg tgagcaccgg ccaggactac tggggcccga tgccggaccc gttcgacccc 22201 gcgttctccg acgccgcagc cagaaccgcg cgagcagtcg ccgacgaggt cgcggacagc 22261 ccgttggcga tcggcgtatt catggacaac gaactgagct ggggcaacgc cggcagtttc 22321 agcacccgtt acggcgtcgt catcgacacc atgtcacgtg acgcggcaga gagccccacc 22381 aagtcggcgt tctccgacga actggaggag aagtacggga ccatcgacgc tctcaacgcc 22441 gcgtggcaga cgacagttcc gtcatgggag gcactccgta gcggcagtgc cgacctcggc 22501 tccgacgaga ccgcgaagga gtccgactac tccgcgctca tgacgctcta cgccactcag 22561 tacttcaaga cggtcgacgc cgagctcgac aaggtcatgc cggaccatct ctacgcgggt 22621 tcgaggttcg ccagctgggg ccgcacaccg gaggtcgtcg aggcagcgag caagtacgtc 22681 gacatcatga gctacaacga gtaccgcgag ggactgcacc cgagcgagtg ggcgtttctc 22741 gaagagctcg acaagcccag cctcatcggt gagttccaca tgggaacgac cactaccggg 22801 cagccgcatc cgggtctcgt ctcggcggga acgcaggccg agcgggcacg gatgtacgcc 22861 gagtacatgg aacagctcat cgacaacccg tacatggtgg gcggccactg gttccagtat 22921 gccgactcgc ccgtgactgg cagagcactc gacggggaga actacaacat tggcttcgtc 22981 tccgtcacgg accgtcccta cccggagatc gtcgccgctg cccgcgacgt gaaccagcgt 23041 ctctatgacc gccgatacgg caacctggcc acggccgagg gacattacac cggtcggcgt 23101 tcagcggagt ag //