LOCUS NC_016776 15720 bp DNA linear CON 17-FEB-2020 DEFINITION Bacteroides fragilis 638R, complete sequence. ACCESSION NC_016776 VERSION NC_016776.1 DBLINK BioProject: PRJNA224116 BioSample: SAMEA3138381 Assembly: GCF_000210835.1 KEYWORDS RefSeq. SOURCE Bacteroides fragilis 638R ORGANISM Bacteroides fragilis 638R Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides. REFERENCE 1 AUTHORS Patrick,S., Blakely,G.W., Houston,S., Moore,J., Abratt,V.R., Bertalan,M., Cerdeno-Tarraga,A.M., Quail,M.A., Corton,N., Corton,C., Bignell,A., Barron,A., Clark,L., Bentley,S.D. and Parkhill,J. TITLE Twenty-eight divergent polysaccharide loci specifying within- and amongst-strain capsule diversity in three strains of Bacteroides fragilis JOURNAL Microbiology (Reading, Engl.) 156 (Pt 11), 3255-3269 (2010) PUBMED 20829291 REFERENCE 2 AUTHORS Aslett,M. TITLE Direct Submission JOURNAL Submitted (16-JUL-2010) Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Date :: 02/17/2020 18:16:11 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Method :: Best-placed reference protein Annotation Software revision :: 4.11 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; Genes (total) :: 4,439 CDSs (total) :: 4,346 Genes (coding) :: 4,241 CDSs (with protein) :: 4,241 Genes (RNA) :: 93 rRNAs :: 6, 6, 6 (5S, 16S, 23S) complete rRNAs :: 6, 6, 6 (5S, 16S, 23S) tRNAs :: 73 ncRNAs :: 2 Pseudo Genes (total) :: 105 CDSs (without protein) :: 105 Pseudo Genes (ambiguous residues) :: 0 of 105 Pseudo Genes (frameshifted) :: 50 of 105 Pseudo Genes (incomplete) :: 48 of 105 Pseudo Genes (internal stop) :: 34 of 105 Pseudo Genes (multiple problems) :: 24 of 105 CRISPR Arrays :: 1 ##Genome-Annotation-Data-END## REFSEQ INFORMATION: The reference sequence was derived from FQ312004. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Data release policy http://www.sanger.ac.uk/legal/#t_2 DNA source: unknown. Annotation Pipeline (PGAP) set; GeneMarkS-2+ repeat_region FEATURES Location/Qualifiers source 1..15720 /organism="Bacteroides fragilis 638R" /mol_type="genomic DNA" /strain="638R" /db_xref="taxon:862962" gene complement(1..954) /locus_tag="BF638R_RS12350" /old_locus_tag="BF638R_2585" CDS complement(1..954) /locus_tag="BF638R_RS12350" /old_locus_tag="BF638R_2585" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005793469.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glycosyltransferase family 4 protein" /protein_id="WP_014299007.1" /translation="MYYLIILVLLFLAEFFYFRIADKCNIIDKPNERSSHTRITLRGGG IIFYLGALAYFLTNQFEYPWFMLALTLITFISFVDDIRSTSQGLRLVFHFTAMALMFYQ WGLFSLPWWTILVALIVCTGIINAYNFMDGINGITGGYSWVVLLALAFINVQIVRFVEE DLIYTMLCAVLVFNFFNFRKKAKCFAGDVGSVSIAFVILFLIGKLIIRTENFSWIILLV VYGVDSVLTIIHRLMLHENIGLPHRKHLYQLMANELEIPHVVVSLIYMTSQAIIIVGYL LTPGWGYCYLLGTIVILSIVYILFMKKYFHLHPAMK" gene complement(1072..1968) /locus_tag="BF638R_RS12355" /old_locus_tag="BF638R_2586" CDS complement(1072..1968) /locus_tag="BF638R_RS12355" /old_locus_tag="BF638R_2586" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005806489.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="NAD-dependent epimerase/dehydratase family protein" /protein_id="WP_014299008.1" /translation="MNLLFTGASGFLGSNLYSLLKDKYQIRTVGLTPRDNYTINLVSDV PKLNIKYDVVLHAAGKAHSIPKTEEEKQLFFDVNLQGTKNLCTALENSGIPKAFIFIST VAVYGCDSGENITEEHPLNGTTPYALSKIKAEKYLEGWCAMHNVKLSILRPSLIAGPNP PGNLGAMIRGIRNGKYLSIAGGKARKSVLMVQDIANLLPMLIEKGGIYNVCDSYQPSFR ELEMVICKQLNKKRPISIPYWLAKSMAVIGDCLGEKAPINSLKLRKITSSLTFSNEKAV RELKWKPMNVLETFLIE" gene complement(1977..2729) /locus_tag="BF638R_RS12360" /old_locus_tag="BF638R_2587" CDS complement(1977..2729) /locus_tag="BF638R_RS12360" /old_locus_tag="BF638R_2587" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008660478.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GT2_Glycos_transf_2|GT2" /protein_id="WP_005793465.1" /translation="MSFSLVTVTYNSAQTLRDTITSVLSQTHQAIEYIIIDGFSKDNTV AIIKEYEPLFNGRLKWISEKDNGLYDAMNKGFQMATGDVIGIINSDDLISDPNAIEKVI KCFEADTSIDAVYADLYYVAQNDISKIVRYWKSGGQRPFCKGWHPAHPTFYVKKEVYQR YGLFDLDFKFAADFELMLRLIDKEHIKLYYLPEPLVRMRLGGTTSKNLSNIRKGNLECI NAFKKNGIKVSMLYPLYRLLPKIRQYFQ" gene complement(2726..3805) /locus_tag="BF638R_RS12365" /old_locus_tag="BF638R_2588" CDS complement(2726..3805) /locus_tag="BF638R_RS12365" /old_locus_tag="BF638R_2588" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008660480.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GT4" /protein_id="WP_139104812.1" /translation="MHMLVLDNIIFSLQRSGGISVVWSELLKRLQLGNLNFECLEYDVM SNINRRQLNLNSKSVQVRKKRFLSITRYFSPRVVKNEKFIFHSSYYRTCSNPNAINITT VHDFTYEYYYKGLKKRIHLWQKHRAISKSNFIICISENTKRDLLKFLPDINETKIRVIH NGVSDDYFPIKEREELELPFELETYMLFVGSREKYKNFELAVKAVACNRLKLVIVGAPL LAEELDFLQTELGQSNFMEMGRVSNEELNCLYNGAMALLYPSEYEGFGIPVLEAQRAGC PVIAYNASSIPEIIGDTPLLLDVLSIESITKCFNVLKIKKEREDIIYKGIENAKRFTWD RMYEQVIALYKEVWEKIKK" gene complement(3809..4939) /locus_tag="BF638R_RS12370" /old_locus_tag="BF638R_2589" CDS complement(3809..4939) /locus_tag="BF638R_RS12370" /old_locus_tag="BF638R_2589" /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /codon_start=1 /transl_table=11 /product="oligosaccharide repeat unit polymerase" /protein_id="WP_144011113.1" /translation="MPIALFKAFFGPAYLLNDGLFDKYYNFAILMANIQLIITLYVTII LFKIFRSYHYSITNFLYKITPKWRIKRTKMFLVSFVFLLLFLISFYLLSSTFGFINWIL SPRTGYQYHRVGAGEYYAFALLFLSTSFSILLLFLRKNKSIYLFSIVYIFFAWFLGSKH IMLNFCIYTITVLWFRNVDNLGKIIGYATPIIFIPMLLNFGSFDLSEIATYFDYYVNSA MYYKEYFSNGIDLFYGQIGLTDYWALVPRSLFPDKPYVYGFLLVNEHFFPGAAEATHTP AFGGPVPYFADFGLIGVIVYSFFNFQLWFQVFCYYIIFVDRRLERIISNPLYIYAVLIL FAPNFLQFFPFPLSVFIFYFLVKLISFINRVVIRTS" gene complement(5071..6144) /locus_tag="BF638R_RS12375" /old_locus_tag="BF638R_2590" CDS complement(5071..6144) /locus_tag="BF638R_RS12375" /old_locus_tag="BF638R_2590" /inference="COORDINATES: protein motif:HMM:NF012744.1,HMM:NF024831.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GT4" /protein_id="WP_014299011.1" /translation="MLSHKKKIAFFFPSFHVGGVEKVFITYANKLIEDDYYEVLIFVCK KEGELLSLVNTSITVVSLNKRLGLCWLPLLYNLKAYSPDVLIAGPDFPNIVALILVRLF RLKIKLLITQHNYYNIESISLGWYGKLLPLFIRFFYRFSDRVISVSDGITGFLCCHNVP MEKITRIYNPIDIKLINLRAQETTEFELPSKYILFVGRLCPVKNLSLLLDAFELISASY TDLNLVIIGSGELNREYQNKKTNQNVFFLGALSNPYPYISKAELIVLSSFSESFSLVVA EALALGTNIVSTPTLGPMEILENGKYGFIYDEFENPNKFASFIMKAINNPLNSEFLKER ALVFDIGYIIKQLKDSF" gene complement(6153..7571) /locus_tag="BF638R_RS12380" /old_locus_tag="BF638R_2591" CDS complement(6153..7571) /locus_tag="BF638R_RS12380" /old_locus_tag="BF638R_2591" /inference="COORDINATES: protein motif:HMM:NF024832.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="gnl|TC-DB|B0RRI5|2.A.66.2.23" /protein_id="WP_014299012.1" /translation="MNRTTISLFWQFIDRFSVQGIQFLIGIVLSRLLSPNDYGIIGIIM VFFTFCDIFVDSGFGKGLIQKTDRTDIDSSTVFFFNIVVSLCCMTILWVTAPFIADFYE NQNLVLLLRVSSFTLLLNALSVVQMSHLIASFSFRSLAKANFLSTFLSGVLAIVLALNR MGVWALVCQYLFRSLILFFVVWFSTRWVPKIVFSKSSFKELYSYSSKIFLGTFVNQIVS NINNIFIAKQLSVSSLGYYTRGQQFPSFIQGALSSIFSNVSLPLLAERKNDMFEFTSQA RNFIKLVMTVTLPMMFLLALLSKPLVVILLTDKWLPCVPIIQIYCLIRLFQSNGIINLN CALAAGRSDVALKVELIKIPLGLLCLIISLKYGLYYFVLGQCILAFINLFIDSHFTGRY INYGILSQIKDSISLFISGMIVAAFSSLFYLVIDNPYIQVIAISLSFCMGYFSILFFLK NKELLYFLKYIKNR" gene complement(7575..8576) /locus_tag="BF638R_RS12385" /old_locus_tag="BF638R_2592" CDS complement(7575..8576) /locus_tag="BF638R_RS12385" /old_locus_tag="BF638R_2592" /inference="COORDINATES: protein motif:HMM:NF013048.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GT0|GT10" /protein_id="WP_014299013.1" /translation="MINIKVSIPDSAPPIIRQTPNSSAKWGDCCFYINTDVAECDYWFV LDELNDTEKTICPSENLILITGEPPYVKLYPHKYVDQFSHVLTCQKNLLKREKACCSNP ALPWMVGAKLKSLPAEWDMNNYLDYGFFCEEHALDKKDKIVVITSNKAMTKGHRQRLDL VLGLKERIPELMDVYGAGFNKVDDKYDILSMYKYSLVMENCRYWNYWTEKLADAYLSLT FPFYSGCPNLDSYFDKNAFEVLNLEDVDKMAVKIEDAIRNDLFSSRKNHILSAKRDVLD KYNLFAMMSTYVSKNEIMSKKEVKTECTIQPLYRTFETRVRTRILKYWGWEI" gene complement(8589..9452) /locus_tag="BF638R_RS12390" /old_locus_tag="BF638R_2593" CDS complement(8589..9452) /locus_tag="BF638R_RS12390" /old_locus_tag="BF638R_2593" /inference="COORDINATES: protein motif:HMM:NF012745.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="GT2_Glycos_transf_2|GT2" /protein_id="WP_032574388.1" /translation="MTYNRPDCVINAIESVRKQSFTNFTLIVSDNSTNSLTEELIRKTY IFPDFIYIKREPPVGGIEHLNLILSEVTSDFFMIFHDDDVMHMNMIESLYNKIQESESY VAVASNAYIINLRKGKRRIFNKLKRDVCILTEHDMCVRYITNDILPFPSYMYRSCIAKK VSFEISEGGKYCDSTFIIKLLNWGTVYWISEPLMDYYEHSGQDSAVWEYWQKNDQIRFL INHSNFRRRDSIVLNFRIQNLYGELSSKGIKSIKGKVFYRYMRIFLYYSPFKLFVRFIA KKVLMM" gene complement(9838..11574) /locus_tag="BF638R_RS12395" /old_locus_tag="BF638R_2594" CDS complement(9838..11574) /locus_tag="BF638R_RS12395" /old_locus_tag="BF638R_2594" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008657400.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="thiamine pyrophosphate-binding protein" /protein_id="WP_008657400.1" /translation="MKVSDYIISYIESRGVHVIFGYIGGMITHLVDSVSQNPNMQFIQT YHEQTAAIAAEGFAKESGLFGVAISTSGPGATNMMTGIADAYFDSIPVLYITGQVNTYE YKYDKPVRQQGFQETDIVSMVKSVTKYAKLIDKAEDIKYELDKALYIALSGRKGPVLLD LPMDIQREEINPETLIGYSGESILNNPLIAWEEIRLLMESSHRPMLLLGAGCCNSDMVL LNDFIRRHHFPVITSLMGRGAIDETYDNYIGMIGSYGNRCANMGVANADLLIALGTRLD TRQTGARLDQFLSNGHIIHVDIDDNELEYHRLLNRKKVNCTIDCFLQKEKEMPISLGDI SEWNFFLHGLKQRYGQDAEIERFVENKSPYRFMQYFDSLTQTDDVICADIGQNQMWAAQ TLRLKSGQKFVTSGGLAPMGFSLPVAIGCSFANPNKKVFSINGDGGFHMAIQSLMLISQ YNLPIKVIILNNASLGMITQFQHLYFDDRMCGTTLNGGYRVPDIKSLSTAYGLPYFRLT VDRLDDPDLREEMQAAHNCIIECVVEGLTSVSPKLEYDKPISKPLPLLPEEEYKENMLS EV" gene complement(11561..12481) /locus_tag="BF638R_RS12400" /old_locus_tag="BF638R_2595" CDS complement(11561..12481) /locus_tag="BF638R_RS12400" /old_locus_tag="BF638R_2595" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_008657401.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="NAD(P)-dependent oxidoreductase" /protein_id="WP_005793446.1" /translation="MKILLTGATGFLGSHIAEALLANDVNLMITKRSMSSLNNCTSFID HVQVINSDNPIWISQACSFSPDIIIHSAWTGVLSGNRYDWPVQLSNIDFMNSLLYIAEK SNVSKFIALGSQAEYGDFDGIVSENAGLFPVNSYGYVKSMVSRMVGSFCDLRGIDWYWL RVFSVYGERESNQWLIPGLLTNMLDNMAGMDLTLGQQRYAYLYVKDFANAVMKVCSGKA PCGVYNLSSSTAIELRVLLEHLRDRLNPAFELRFGALPYRAGQPMLVQGDVSKFVKSFG HFENTPLNAGLEYTITYYKKQHESI" gene complement(12478..13557) /gene="rfbG" /locus_tag="BF638R_RS12405" /old_locus_tag="BF638R_2596" CDS complement(12478..13557) /gene="rfbG" /locus_tag="BF638R_RS12405" /old_locus_tag="BF638R_2596" /EC_number="4.2.1.45" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014299015.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="CDP-glucose 4,6-dehydratase" /protein_id="WP_014299015.1" /translation="MGIDIFDNFYRGKRVLVTGHTGFKGSWLSIWLHELGAEVIGVAQD PFTARDNFVLSGIGEKIKADLRADIRDGERIKAIFQEYQPEIVFHLAAQPLVRLSYDIP VETYETNVMGTIHVLEAVRSTDSVKVGVMITTDKCYENKEQIWGYRENEPMGGYDPYSS SKGAAEIAIASWRRSFFNPSEYARHGKSIASVRAGNVIGGGDWALDRIIPDCIKALESG AAIDIRSPKAIRPWQHVLEPLSGYMLLAQKMWDAPTDYCEGWNFGPRSESISTVWDVAT RVVSEYGRGELRDLSTPDALHEARLLMLDISKARFCLGWEPRMNIGQTVGLTVDWYKRY REEEVYDVCVDQIKDYLLK" gene complement(13563..14339) /gene="rfbF" /locus_tag="BF638R_RS12410" /old_locus_tag="BF638R_2597" CDS complement(13563..14339) /gene="rfbF" /locus_tag="BF638R_RS12410" /old_locus_tag="BF638R_2597" /EC_number="2.7.7.33" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005806514.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase" /protein_id="WP_005781149.1" /translation="MKAVILAGGFGTRLSEATNLIPKPMVEIGGKPILWHIMKTYSHYG INDFVICCGYKQYIIKEYFANYFRHNSDMTVDLSNNTTTILDNHSENWKVTMVDTGLNT QTGGRIRRVQKYLGNERFLLTYGDGVTDLNIGDTLKAHESSGCLLSLTAYKPGGKFGAL QLDLDTDKVLSFQEKPDGDRNWINAGYFVCEPEVFDYIPEGDSTIFERQPLESIAKAGR MHAFRHTGFWKPMDTLRDNTELNEMWDQGVAPWKVW" gene complement(14377..15720) /gene="rfbH" /locus_tag="BF638R_RS12415" /old_locus_tag="BF638R_2598" CDS complement(14377..15720) /gene="rfbH" /locus_tag="BF638R_RS12415" /old_locus_tag="BF638R_2598" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005790531.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="STP|Aminotran_1_2" /protein_id="WP_005793443.1" /translation="MSKKETLKQQILDLTREYYKEVHGSSRSFEPGKSFVNYGGRYFDD RELVNLVDSSLDFWLTAGPWARKFEIRFAEWLGVKYCSLTNSGSSANLLAFMALTSPQL GERRIRRGDEVITVACGFPTTVTPCIQYGAVPVFVDVTIPEYNIDVTQLEAALSPKTKA VMIAHSLGNPFDLQAVKDFCDKHNLWLVEDNCDALGSTYTIDGVEKKTGTIGHIGTSSF YPPHHMTMGEGGAVYTDDPLLHKLVNSFRDWGRDCWCIGGVDNTCKYRFSKQFGDLPVG YDHKYVYSHFGYNLKVTDMQAAIGCAQLEKLDSIVEARRSNFAYLKEGLAGTSGLILPE AQKNSDPSWFGFLISVKEDAGFTRNDLSQHLESRKIQTRNLFAGNLLKHPAFDEMRSTG EGYRVIGNLEGTDYVMNHTLWIGVYPGMTRAMLDHMIGTIRDFVSSRK" ORIGIN 1 tcatttcata gccggatgca aatggaaata tttcttcata aataagatat acactatact 61 taatatgaca attgtgccca ataaataaca ataaccccaa ccgggagtta acagataacc 121 aacaataatt atggcttgtg atgtcatgta aatcagtgaa accaccacat gcgggatctc 181 cagttcattt gccatcaact gatataagtg tttccgatgt ggcaaaccaa tattttcatg 241 tagcataagc cgatggataa tagtcagcac actatctact ccataaacca caagcaaaat 301 aatccaactg aaattctctg ttcgaattat tagtttacct atcaggaaaa gaatcacaaa 361 ggcaatactg accgatccca catccccggc aaagcattta gccttcttgc gaaaattgaa 421 aaaattaaat accaacacag cacaaagcat agtgtatatc agatcctcct ccacaaaacg 481 gacaatttgc acattgataa aagctaaagc aagtaataca acccaagaat accctcccgt 541 aatgccatta atcccatcca taaagttata agcattgata atgcctgtac atacaatcaa 601 ggcaacaagg atagtccacc aaggcagact gaataatccc cattgataaa acatcaaggc 661 cattgcagta aaatgaaaaa ctaaacgcaa tccctgagag gtagagcgaa tgtcgtccac 721 aaaactaata aaggttatca aagtcagagc cagcataaac caaggatact caaactgatt 781 tgtcagaaaa taagccaatg cacccaagta gaaaataata cctccgcccc gtagcgtgat 841 ccgggtatgc gaactccgtt cgttcggttt atcgatgata ttgcatttat cagcaatacg 901 gaaataaaaa aattctgcca ggaatagcag aactaagatt atcagataat acataagtta 961 ttcattcttg tctattaaat gaaaccaaaa ctggagccct aaaaagacta aagctgccaa 1021 tccggtcaaa atgcccataa tccaaagaaa agtttccatc cgcactttct tctattctat 1081 aagaaaagtc tccagcacat tcatgggctt ccacttgagt tcccgtacag ccttttcatt 1141 actaaaggtc aaagagcttg tgattttacg aagtttcaat gaattgatcg gagctttttc 1201 acccaggcaa tctccaatga cagccatact tttagccaac caataaggaa tagatattgg 1261 tcttttttta ttcaattgct tacatatcac catctccagt tcacgaaaac tcggctggta 1321 actgtcacaa acattatata tcccaccctt ttctattaac ataggaagaa gatttgcaat 1381 atcctgaacc atcagaacac ttttccgggc ttttcccccg gcaatactta agtacttacc 1441 atttctaatc ccacgaatca tcgctcctaa atttccagga ggattaggtc cggcaatcaa 1501 tgaaggacga agtatactta actttacatt atgcatagca caccaccctt ccaagtattt 1561 ctcagcctta atcttactca aagcataagg agtagttcca tttaaaggat gctcttccgt 1621 gatattctca cccgaatcac aaccataaac ggcaacggta ctaataaaaa tgaaagcttt 1681 aggaatacca ctattctcta aagcagtgca taagttcttg gtaccctgaa gatttacatc 1741 aaaaaagagt tgtttctctt cttctgtttt aggaatagaa tgcgctttac ctgcagcatg 1801 cagcacaaca tcgtacttga tattcagttt aggaacatcc gacactaaat ttatagtata 1861 attatcccga ggagtcagcc ccacagtcct aatttgatat ttatctttca gtagagaata 1921 aagattgctg cctaaaaagc cagaagcacc agtaaaaaga agattcattg attatattat 1981 tgaaaatatt gcctgatttt gggtaataaa cgatataaag gatataacat actcactttt 2041 attccgttct ttttaaaagc atttatacat tcaagatttc ctttcctaat attagataga 2101 ttcttacttg tagttccccc taatcgcatc ctgactaaag gttcaggaag ataatataat 2161 ttaatatgct ctttatcaat caaacgaagc attaactcaa aatctgctgc gaacttaaaa 2221 tccagatcga acaacccata tctctgatat acttccttct tcacataaaa tgtaggatga 2281 gccggatgcc accctttaca gaaaggacgt tgtccccctg atttccaata ccgaactatt 2341 ttagatatat cgttctgagc aacataatat aaatcagcat aaacagcatc aatagaagta 2401 tctgcttcaa agcattttat cactttttca attgcattag gatcagatat taaatcgtca 2461 gaattaataa tcccaatcac atctcctgtt gccatttgaa aacctttatt catcgcatca 2521 tacaagccat tgtccttttc actaatccac ttcaggcgcc cattaaacaa tggctcatac 2581 tcttttataa tcgccacagt gttatctttc gaaaaaccat ctattattat gtactctata 2641 gcttgatgag tttgtgataa tacagaagtt atagtatcac gtagtgtctg tgcgctattg 2701 taagttactg taactaaaga gaaactcatt tttttatttt ctcccatact tccttatata 2761 aagcgattac ttgctcatac attctgtccc atgtaaagcg ttttgcattc tcaattcctt 2821 tataaataat atcttcacgt tcctttttta tcttcaatac attaaaacat tttgttatag 2881 attctattga caatacatca agcaataacg gagtatcacc tattatttca ggaatagatg 2941 aagcattgta tgcaataaca ggacaacctg ccctctgtgc ctctaataca gggattccaa 3001 agccttcgta ttccgaagga tacaaaagag ccattgctcc attatacaga caattaagtt 3061 cttcattaga aacacgtccc atttccatga aattggactg tcccaattct gtttgtaaaa 3121 agtccaactc ttcagcaagt agaggtgcac caactatcac taattttaat ctattacatg 3181 ctaccgcctt tactgctaat tcaaagtttt tatacttttc acgagagcct acaaatagca 3241 tataggtttc tagttcaaaa ggtaattcaa gttcttctct ttctttaatt ggaaaataat 3301 catcagaaac tccattatga ataacacgta ttttagtttc attgatatcc ggtagaaact 3361 tcaataaatc acgttttgta ttctctgata tacatattat aaaatttgat ttggatatag 3421 cacgatgttt ttgccataaa tgaatccttt tttttaaacc cttataatag tattcatatg 3481 taaaatcatg aacagttgtg atattaatgg cattaggatt actgcaagta cgataataag 3541 aagaatgaaa gataaatttc tcattcttga caaccctagg tgagaaatat ctagtaatac 3601 ttagaaacct tttctttcta acttgaacac ttttagaatt aagattcaac tgcctacgat 3661 ttatattact cataacatca tactctaagc actcaaaatt caaattgcca agttgcaatc 3721 ttttcaataa ttcagaccaa acaacagaaa tacctccgga cctttgcaat gaaaaaatta 3781 tattatcaag aactaacata tgtattattt agctggttct aattactacg cgattaataa 3841 aagagatgag ctttactaaa aaataaaata taaaaacaga gagtggaaat gggaaaaatt 3901 gcaaaaaatt aggagcaaat aatatcaata ccgcatatat atataatgga tttgatatta 3961 tacgttccaa ccttctatct acaaaaatta tatagtaaca aaatacctga aaccataatt 4021 gaaagttaaa aaaagaatat acaataactc ctattaaacc aaaatctgca aaataaggaa 4081 ctggcccacc aaaagccgga gtatgagtcg cctctgcagc acctggaaaa aaatgttcat 4141 taactaataa gaagccataa acgtacggtt tatcaggaaa caaacttctt ggaacaagtg 4201 cccaataatc agttaagcct atttgaccat aaaataagtc tattccattt gagaaatact 4261 ctttataata cattgcacta ttaacataat aatcaaaata tgtagcaatt tcgctcaaat 4321 caaaacttcc aaaattaaga agcattggaa taaatatgat tggagtggca taccctataa 4381 ttttgcccag attatctaca tttctaaacc agagaacagt aatcgtataa atgcagaaat 4441 ttaacataat atgttttgaa cctaagaacc aagcaaaaaa gatatataca attgaaaaaa 4501 gatagatact tttattcttt ctcaaaaaaa gtaacaatat ggaaaatgaa gtggaaagga 4561 atagtaaagc aaaagcataa tattctccag caccaacccg gtgatattga taaccggttc 4621 taggagataa aatccaattt ataaaaccga aagttgaaga taataaataa aaagaaataa 4681 gaaacaagag taaaaaaaca aatgagacta aaaacatctt agttcttttt attctccatt 4741 tcggtgtaat tttatacaaa aaattagtta tactatagtg atatgatcta aatattttaa 4801 ataatattat tgtaacatac agagttatta ttaactgaat atttgccatc agaatagcaa 4861 aattataata cttatcaaag agtccatcat taagtaaata tgctggtcca aaaaaagctt 4921 taaacaaagc tattggcata gtaactacga ctaatatagt aattgggttt aataacttta 4981 attttagaga tttagatata tatattggat aatatatagt caaaaacaca aaaaaaaaca 5041 aattaattaa acataggaag tccatcatta ttaaaagcta tcctttaact gttttataat 5101 ataaccaata tcaaatacga gtgctcgctc tttcaaaaac tcagaattaa gaggattatt 5161 aatggccttc ataataaacg acgcaaattt attgggattt tcaaattcat cataaataaa 5221 accatatttt ccattttcta atatttccat aggtcctaaa gttggagtag acactatatt 5281 tgtacctaaa gctaaagctt ctgccacgac caatgaaaaa ctttcagaga aagatgataa 5341 gacaattaac tcagctttgc ttatatatgg ataaggatta gataatgctc ctaaaaaaaa 5401 tacattttga tttgtttttt tattttgata ctctctattc aactcaccag agccaataat 5461 caccaaattc aagtcagtat atgatgctga aattaattca aaagcatcta ataacaatga 5521 taaattttta acagggcaca accttccaac aaaaagaatg tactttgaag gtagttcaaa 5581 ttctgttgtt tcctgtgctc tcaaatttat taatttaata tcaataggat tatatatacg 5641 agtaattttt tccattggta cattatgaca acataaaaaa ccagtaatac catcagatac 5701 agaaattact ctatcactaa aacgatagaa aaaccttata aacaaaggta ataatttgcc 5761 ataccaccct aatgaaatag actctatatt atagtaatta tgttgagtga ttaacaattt 5821 tatttttaac ctgaataagc gaactaatat caaagcaact atattgggaa aatctggtcc 5881 tgcaattaag acatcaggag aatatgcttt aagattatac aataaaggta accaacaaag 5941 tccaagacgc ttatttaatg agacaactgt aatactagta ttcaccaaag ataatagttc 6001 accttctttt ttacaaacaa aaattagaac ttcataataa tcatcctcaa tcagtttatt 6061 ggcatatgtt ataaatacct tttccactcc tccaacatga aaactaggga aaaagaaagc 6121 aattttcttt ttatgagata gcatatatag tattatctat ttttaatata tttcaaaaaa 6181 tatagtaatt ctttattttt caagaaaaaa agaattgaaa aataacccat acaaaacgac 6241 aatgaaatag ctatcacctg aatatatggg ttatcaatta ccaaataaaa caaagaagaa 6301 aatgcagcta caatcatacc agaaataaat aatgatattg aatcctttat ttgtgataag 6361 ataccgtaat taatatagcg tcccgtaaaa tgtgaatcaa tgaataaatt tataaaagct 6421 aaaatacatt gccccaaaac aaaatagtac agtccatatt ttaaactaat aataagacac 6481 aataatccta atggaatctt tatcaattca actttcaatg caacatcaga acgacctgcg 6541 gccaatgcac aatttaaatt tattattcca ttactttgga acagtctaat taaacagtat 6601 atttgaatta ttggaacaca tggtaaccac ttatcagtta ataatataac taccaaaggt 6661 tttgataaaa gagctaataa aaacatcata ggtaaagtta cggtcatcac taattttata 6721 aaatttcttg cctgtgatgt gaattcaaac atatcatttt ttctctccgc taaaaggggt 6781 aaagatacat ttgaaaaaat agaagaaagt gctccttgaa taaaagaagg gaactgttgc 6841 cctcgtgtat aataccctaa actcgaaacc gacagttgtt ttgctataaa aatattattt 6901 atattgctaa caatctgatt gacaaatgta cccaaaaaga tcttactact ataagaatac 6961 aattccttga aagatgactt tgaaaaaaca atttttggta cccacctagt tgaaaaccaa 7021 acaacaaaaa ataaaatcag acttctaaat aaatactggc agactaatgc ccaaactccc 7081 attcgattca gagccagtac aatagctaat acaccactta aaaaagtaga aaggaagtta 7141 gcttttgcca acgatctaaa agaaaaagaa gctatcaaat ggctcatctg aacaacagaa 7201 agtgcattta gtaatagagt gaacgatgag actcttaaca ataaaaccaa attctgattt 7261 tcataaaaat cagcaataaa cggagctgta acccataata ttgtcatgca acacaaactc 7321 acaacaatat taaaaaaaaa tacagttgaa gaatcaatat ctgttctatc agttttctga 7381 atcaatcctt taccaaaacc actatcaaca aaaatatcac aaaaggtaaa aaaaaccatt 7441 ataatgccaa taataccata atcattagga gataatagcc tagaaagaac aatccctatt 7501 aaaaattgaa taccttgtac agaaaaacgg tcaataaatt gccaaaataa gcttatagta 7561 gtcctattca taaactatat ttcccatccc caatatttga gaatgcgagt tctaactctt 7621 gtttcaaaag ttctataaag tggctgtatc gtacattcag ttttcacttc ttttttggac 7681 attatttcgt ttttcgacac ataagtcgac atcatagcaa acaaattata cttatctaat 7741 acatctcttt tagcagaaag gatatgattc tttctactag aaaagaggtc atttcttatt 7801 gcatcttcta tttttacagc cattttatct acatcttcca aattcaatac ttcaaaagca 7861 ttcttatcaa aatatgaatc aagattaggg catcccgaat aaaaaggaaa tgttaaactg 7921 agatatgcat cagctaattt ctcagtccaa taattccaat atctgcaatt ttccattacc 7981 aacgaatact tatacataga taatatatca tatttatcat ccactttatt aaaaccagct 8041 ccataaacat ccattagttc aggaatccgc tcttttaaac caagaaccaa atctaacctt 8101 tgtctatgtc ctttagtcat agctttatta gaggtaataa ctacaatctt atctttctta 8161 tccaatgcat gttcttcaca gaaaaaacca taatccaaat aattattcat atcccattct 8221 gcaggtaaag actttaactt cgcccccacc atccaaggta acgcaggatt cgaacaacat 8281 gctttttccc tctttaacaa attcttctga cacgtcaaaa catgtgaaaa ttgatctaca 8341 tatttatgag gatacaattt tacataggga ggttctccag ttattagaat aagattttcc 8401 gaaggacaaa tagttttctc cgtatcattt agttcatcaa gaacaaacca ataatcacat 8461 tctgctacat ctgtatttat ataaaaacaa caatcacccc attttgcaga agagttgggc 8521 gtttgcctaa taataggagg agcagagtca ggtattgaaa ctttaatatt aatcataaac 8581 aatcaatatc acatcattaa tacttttttt gcaataaatc gaacgaataa cttaaatgga 8641 gaataataaa gaaatatcct catatatcta taaaatacct tccctttaat actcttaatt 8701 cctttgcttg atagttcacc atataaattt tgtattctga aatttaaaac gatagaatct 8761 ctccgtctaa aattggaatg attaattaaa aaccgaatct gatcgttttt ttgccaatat 8821 tcccaaactg cactatcctg tccagaatgc tcataataat ccattaatgg ctccgatatc 8881 caataaactg taccccaatt taataatttt ataataaaag tagaatcgca atactttccc 8941 ccttcgctta tttcaaaact gactttctta gcaatacagc ttctatacat ataagatgga 9001 aaaggtaaaa tatcatttgt aatataccta acacacatat catgctctgt taatatacat 9061 acatctcgtt tcagtttatt gaaaattctc ctttttccct tacgtaaatt tataatatat 9121 gcattacttg ccaccgctac ataagattca ctttcctgta ttttattata aagagattca 9181 atcatattca tatgcatcac atcatcatca tgaaatatca tgaagaagtc cgatgtaacc 9241 tcagataaaa ttagatttaa atgctcaatt cctcccactg gtggttcacg ttttatataa 9301 ataaaatcag gaaatatata tgtttttctt attaattctt ccgttaaact atttgtcgaa 9361 ttatccgaaa caattaaagt aaaattagta aaagattgtt tccgtacaga ctctattgca 9421 ttaattacac aatcaggtct attataagtc attatatata tctgcatttc ttccagtaaa 9481 catttaaaac atactataca tttccaaaaa tggacatcta ctgtcacgct tcactataag 9541 cagaatattt tttactatca ttcacaaata atctattaaa attcaatata aaacactcca 9601 taaaataagc aaaataaata tatcaaaaaa tccattgaag ccactcttaa tattttgtta 9661 ggaaaatatt ttaaaaaaaa ttgccaatat tttttatata caaataaaga caaaaataaa 9721 ataaatcaag acactatttt ttaatgtcta ctgtcattac tccaaatgcc tacattgccc 9781 taactcaatt tgattggatt atattaatat catacaactc acagataaag tatacaatca 9841 aacctctgat agcatattct ccttatattc ttcttctggc aataaaggta aaggcttgga 9901 aataggctta tcgtattcca atttcggaga aacactagtc aagccttcta ccacacattc 9961 aataatacag ttgtgggctg cctgcatctc ttcccgcaaa tcaggatcat ccaaccgatc 10021 aacagtcaat ctaaaataag gtaagccata agccgtagag agagatttaa tatccggcac 10081 tctgtagcct ccattcaaag tagttccaca cattcgatca tcaaaataca aatgttgaaa 10141 ttgagtaatc atacctaaag aagcattatt caatattatt accttaatag gaagattata 10201 ttgagaaata agcatcaaag actggatagc catatgaaaa cctccatcac catttatgga 10261 aaaaactttt ttatttggat tggcaaacga acacccgatg gctaccggta atgaaaagcc 10321 cattggggca agtccgccac ttgttacaaa tttttgcccg gattttaacc gtaaggtttg 10381 agccgcccac atttgattct gacctatatc cgcacatata acatcgtcgg tttgagtcaa 10441 agaatcaaaa tactgcatga agcgatatgg agatttgttt tcaacaaaac gctctatttc 10501 tgcatcctga ccatatcgtt gcttgagccc atgcaggaaa aaattccact ctgaaatgtc 10561 ccctaaagaa atcggcattt ctttttcctt ctgtagaaag caatcaatgg tacaattcac 10621 ttttttacga ttcaataaac gatgatattc cagttcgttg tcatcaatat caacatgaat 10681 gatgtgccca tttgataaaa attgatccaa ccgggcaccg gtctgtcgag tatccaatct 10741 ggttcctaat gcaatcaaca aatcggcatt ggcaactccc atgttagcac aacggttacc 10801 ataactgcct atcatcccaa tgtaattatc gtatgtttca tcaatagccc ctctacccat 10861 taaagaagta ataaccggga aatggtgccg tcttatgaaa tcattcagca aaaccatatc 10921 cgaattgcaa catcctgccc ctaaaagcaa catgggacga tgggacgact ccattaataa 10981 cctgatttcc tcccaagcta tcaaaggatt atttaaaata ctctcaccgg aatatccgat 11041 caatgtttcc ggattaattt cctcccgttg gatatccatt ggcagatcca gcagtacagg 11101 cccttttcta cccgacaaag caatatataa ggctttatcc agttcatatt taatatcttc 11161 agccttatct atcaatttgg catatttagt gacggactta accatactta caatatccgt 11221 ctcctgaaaa ccttgctgac ggacaggctt atcatatttg tattcatatg tattcacctg 11281 acccgttata taaagaaccg gaatagagtc aaaatatgcg tcagcaatac ccgtcatcat 11341 attagtagct ccaggaccac tggtcgaaat agcaactcca aaaagtccgg attctttcgc 11401 aaagccttct gcagcgatag cagcggtctg ttcgtggtaa gtttgaataa attgcatatt 11461 cggattctga gaaacagaat cgaccagatg ggtgatcatt ccacctatat atccgaatat 11521 gacatgtact ccccgggact cgatatacga tattatatag tcagatactt tcatgttgtt 11581 ttttataata agtgatagta tactccaaac cggcatttaa cggtgtattc tcaaagtgcc 11641 caaacgactt tacaaatttc gacacatcac cttgcaccaa cattggttga ccggcacgat 11701 agggcaacgc accaaaacgc aactcaaaag ccggatttaa tctatctctc aaatgttcaa 11761 gaagtactct taattcgatc gcagtagaag atgataaatt atagacaccg cagggagctt 11821 tccctgaaca tactttcatt acggcattgg caaagtcctt cacatataaa taagcgtagc 11881 gttgttgccc taaagtcaga tccataccag ccatattgtc aagcatatta gtcaaaagac 11941 cggggatcag ccattggttt gactcccgct ctccgtatac ggaaaaaact cttaaccagt 12001 accaatcaat cccacgtaaa tcacaaaaag aaccaaccat ccgggaaacc atggacttca 12061 cgtatccata gctattgaca ggaaacaagc cggcattttc agagactatc ccatcaaaat 12121 ccccatattc ggcctgacta cccaaagcta taaatttaga aacgttactt ttctctgcta 12181 tataaagcaa agaattcata aagtcaatat tagacagttg gaccggccaa tcgtatctat 12241 tgccagacag gacccccgtc caggctgaat gaataataat atcagggcta aaagagcaag 12301 cttgggatat ccagataggg ttatccgagt ttatgacttg tacatgatca atgaaagagg 12361 tacaattgtt caacgaagac attgaccgtt tagttatcat caggttaaca tcgtttgcca 12421 gcaaggcttc tgcaatatgc gatcctaaaa aaccagtcgc ccccgtcaat aatatcttca 12481 tttcaataaa taatctttta tctggtcaac acaaacatca tatacctctt cttcccggta 12541 tctcttatac cagtccaccg tcaatccgac cgtctgcccg atattcatcc taggctccca 12601 gcccagacag aaccgagcct tggagatatc caacatcaaa agccgggctt catgcaatgc 12661 atccggagta gaaaggtcac gcagttcacc ccgcccatac tcggacacaa cccgggtggc 12721 cacatcccaa actgtcgaga tggactcgga acggggaccg aagttccagc cctcacaata 12781 gtccgtaggg gcgtcccaca tcttctgcgc aagcagcata taaccgctca acggttcaag 12841 tacatgctgc cagggacgga tagctttcgg acttcggata tcgatagccg ctccagattc 12901 caaagccttg atgcagtccg gaatgatacg gtccaaggcc cagtcgccac cgccgatcac 12961 attaccagca cgtacactgg ctatgctttt gccgtgtcgg gcatactccg aggggttgaa 13021 gaaagaacga cgccatgaag caatagcaat ctcagcggct cccttgctac tggaataagg 13081 gtcataaccg cccataggct cgttttcacg atagccccag atttgctctt tattctcgta 13141 acatttatct gtggtaatca tcacacctac cttcacgcta tccgtagaac ggactgcctc 13201 aagaacatgg attgttccca ttacattggt ttcgtaggtt tcaacaggga tgtcataact 13261 caagcgaacc agaggttggg cagcaagatg aaaaacaatc tcaggttgat attcctgaaa 13321 gatagccttt atacgctcac catcgcggat atcggcacga aggtcggcct taattttctc 13381 gccgataccg gaaagtacga aattgtctcg agccgtaaaa gggtcttgag ccacaccaat 13441 cacctcggcc cccaattcat gcaaccagat ggagagccag ctacctttaa aacccgtatg 13501 accggtgaca aggacacgtt tgccccgata aaaattatca aatatatcaa ttcccatacg 13561 gcttaccaca ctttccaggg agcgactccc tgatcccaca tttcattcaa ttctgtattg 13621 tctctcagag tatccatcgg tttccagaaa cccgtatgac ggaaagcgtg catccggccc 13681 gccttggcta tagactcgag gggttgccgc tcaaagatgg tggagtcacc ctcagggata 13741 taatcgaaca cttcgggttc acacacaaaa tagcccgcat tgatccagtt acggtccccg 13801 tcgggcttct cctggaaaga gaggaccttg tccgtatcga gatcgagctg cagggcgccg 13861 aacttaccac cgggtttgta ggccgtaagg gaaaggaggc agcccgaaga ctcgtgagcc 13921 ttcagggtat caccgatgtt caggtcggtg acaccgtcac cataggtcag caggaaacgt 13981 tcgttcccga gatatttctg tacacgccgg atacgcccgc ccgtttgggt gttcagcccg 14041 gtatcaacca tcgtgacttt ccagttctcg gaatggttgt ccagaatggt ggtcgtattg 14101 ttggaaaggt ccacggtcat atcgctgtta tgacggaaat agttggcgaa atactccttg 14161 atgatatatt gtttataacc gcagcagatc acgaaatcgt tgatgccata atggctgtag 14221 gttttcatga tatgccagag gatgggttta ccaccgatct ccaccatagg tttggggatc 14281 aggttagtgg cttcgctcag gcgggtgccg aagccaccgg ctaaaatgac ggctttcatt 14341 atgcttgaca gattattgaa ggttaataac cggaaattac ttacgggaag agacaaagtc 14401 acggatcgta ccgatcatgt ggtcgagcat ggcacgggtc atgcccggat agacaccgat 14461 ccagagggta tgattcataa cgtaatcagt accttccaaa ttgccgatta cgcggtatcc 14521 ctcacccgtg gaacgcattt catcaaaggc gggatgcttc agtaggttgc ccgcaaacag 14581 gttgcgtgtc tggatcttcc tgctctccag gtgttgggaa aggtcgttac gggtgaagcc 14641 cgcatcttcc ttcaccgaaa taaggaagcc gaaccagctc gggtcggagt tcttctgcgc 14701 ttcgggaagg ataaggccag atgtacccgc aaggccttct ttcaggtagg cgaagttcga 14761 ccgccgggct tcgacaatgg agtccagctt ctcaagctgg gcacagccga tggcggcctg 14821 catatcggtc actttcaggt tatacccgaa atgggaatag acatatttat ggtcgtaacc 14881 taccgggagg tcaccgaact gtttgctgaa acggtatttg cacgtgttgt caacaccccc 14941 gatgcaccag cagtcacggc cccagtcacg gaaagagttg accagtttgt gcagcagagg 15001 atcatcggta tagacagcac cgccctctcc catcgtcatg tggtgtggag gataaaagct 15061 acttgtgccg atatggccga tcgtacctgt tttcttttct acaccgtcga ttgtataagt 15121 agagccaagg gcatcgcaat tatcctctac caaccagagg ttatgtttat cacagaaatc 15181 tttgacagcc tgcaaatcaa acgggttacc caaagagtgg gcaatcatta ccgctttagt 15241 tttgggagat aatgcggctt ccagttgagt cacgtcgata ttgtactcgg ggatggtgac 15301 atccacaaaa acagggaccg caccatactg gatgcagggg gtcacggttg tgggaaagcc 15361 gcaggctacc gtgatcactt catcaccccg cctgattctg cgctcaccca actgcggcga 15421 ggtcagggcc ataaaggcaa gaaggttggc cgaagagccc gaattggtca gggagcaata 15481 tttaacaccc aaccattcgg caaaacggat ttcaaacttc cgggcccacg gaccggcggt 15541 cagccagaaa tcaagggatg agtcaaccag gttcaccagt tcgcggtcat caaaataacg 15601 gccgccatag ttgacaaaac tcttaccggg ttcgaaggag cgggaggacc cgtgaacctc 15661 tttgtagtat tcccgggtta aatcgagaat ttgttgcttg agtgtttctt tcttactcat //