Browse anti-prokaryotic immune system families by Host order

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS104 narp2_nampt NAD+ reconstitution pathway (NARP) CLAN043 Vibrio phage KVP40 Osterman et al., 2024 Nicotinamide phosphoribosyltransferase activity (Nampt), capable of producing NMN from PRPP and nicotinamide.
APIS113 antiDnd_p0020 Dnd CLAN044 Vibrio phage 44E38.1 PMID:35760840 Two genes (p0020 and p0021) provide resistance to the Dnd system (anti-Dnd), p0020 encodes a protein with a phosphoadenosine phosphosulphate reductase (PAPS) domain and a DNA N-6-adenine-methyltransferase (Dam) domain.
APIS131 vcrx091 CRISPR-Cas evasion by DNA repair CLAN083 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
APIS133 vcrx092 CRISPR-Cas evasion by DNA repair CLAN046 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
APIS148 OrbA bacteriophage exclusion (BREX) CLAN085 Vibrio phage ICP1 PMID:34326207 Clinical phage ICP1 overcomes cocirculating SXT ICEs through acquisition of epigenetic RM as well as an anti-BREX protein, OrbA.
APIS153 antiDnd_p0021 Dnd CLAN086 Vibrio phage 44E38.1 PMID:35760840 Two genes (p0020 and p0021) provide resistance to the Dnd system (anti-Dnd), p0021 encodes a protein of unknown function.
APIS166 vcrx089 restriction-modification (RM) CLAN004 Vibrio cholerae PMID:32556263 vcrx089 and vcrx090 promote resistance against type I restriction-modification.
APIS170 narp2_nmnat NAD+ reconstitution pathway (NARP) CLAN020 Vibrio phage KVP40 Osterman et al., 2024 Nicotinamide mononucleotide adenylyltransferase (Nmnat), capable of generating NAD+ by conjugating AMP to NMN.
APIS176 CLAN005
APIS185 vcrx093 CRISPR-Cas evasion by DNA repair CLAN006 Vibrio cholerae PMID:32556263 CRISPR–Cas evasion by repairing double-strand DNA breaks via recombination between short sequence repeats
vcrx090 vcrx090 restriction-modification (RM) CLAN119 Vibrio cholerae PMID:32556263 vcrx089 and vcrx090 promote resistance against type I restriction-modification.
anhur anhur Septu CLAN109 Vibrio phage 1.196.O._10N.286.54.E12 Lopatina et al., 2024 Phage-encoded anti-Septu protein; inhibits the Septu/PtuAB ATPase–nuclease defense system and allows phage escape from Septu-mediated abortive infection.
APIS213 surt AbiU CLAN013 Vibrio phage 1.217.O._10N.261.45.A1 Lopatina et al., 2024 Phage anti-AbiU protein; counteracts AbiU abortive-infection defense and restores phage propagation in AbiU-containing hosts.
APIS282 svarog Septu CLAN095 Vibrio phage 1.066.O._10N.286.46.E8 Lopatina et al., 2024 Anti-Septu phage protein; functionally suppresses Septu defense, likely by interfering with the PtuAB effector module or its activation.
hades hades DRT type I CLAN054 Vibrio phage 1.066.O._10N.286.46.E8 Lopatina et al., 2024 Anti-DRT type I protein; phage-encoded inhibitor of DRT/retron-like defense, preventing type I DRT-mediated restriction or abortive infection.
kali kali DRT type III CLAN115 Vibrio phage 1.139.B._10N.261.48.C6 Lopatina et al., 2024 Anti-DRT type III protein; viral counter-defense factor that suppresses type III DRT activity during phage infection.
enki enki AbiH,Retron type II CLAN113 Vibrio phage 1.080.O._10N.286.48.A4 Lopatina et al., 2024 Broad anti-defense protein reported against AbiH and type II Retron systems; likely helps phage evade abortive-infection/retron-associated immune responses.
nergal nergal Type I CBASS CLAN116 Vibrio phage 1.209.O._10N.222.52.B2 Lopatina et al., 2024 Anti-CBASS type I protein; inhibits cyclic-oligonucleotide-based CBASS defense, probably by blocking signaling or effector activation.
tlaloc tlaloc AbiH CLAN118 Vibrio phage 1.056.O._10N.261.48.C11 Lopatina et al., 2024 Anti-AbiH protein; phage inhibitor of AbiH abortive-infection defense, allowing phage replication despite AbiH activity.
APIS207 adfB toxin-antitoxin (TA) CLAN092 Vibrio phage ICP1 PMID:39287445 AdfB functions as an antitoxin, abrogating DarT toxicity through direct interactions.
APIS269 oad1 Class 1 OLD nucleases CLAN094 Vibrio phage ICP1 PMID:39829814 OLD anti-defense 1 (Oad1) is a direct inhibitor of Vibrio cholerae-encoded Class 1 OLD family nuclease.
APIS286 VPG01_164 Kongming CLAN021 Vibrio phage VPG01 PMID:39977546 The protein robustly suppressed cell death triggered by Kongming and their respective DNKs, indicating anti-Kongming function.