Browse anti-prokaryotic immune system families by Host order

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS045 CLAN001
APIS046 CLAN009
APIS047 CLAN018
APIS050 CLAN018
APIS051 CLAN005
APIS052 CLAN001
APIS053 CLAN009
APIS054 CLAN008
APIS056 CLAN023
APIS057 CLAN009
APIS058 CLAN008
APIS060 CLAN008
APIS061 CLAN001
APIS062 CLAN008
APIS063 CLAN005
APIS064 CLAN008
APIS066 CLAN008
APIS067 CLAN005
APIS068 CLAN009
APIS069 CLAN011
APIS070 CLAN001
APIS071 CLAN009
APIS073 CLAN008
APIS074 CLAN018
APIS076 CLAN008
APIS081 CLAN040
APIS082 CLAN018
APIS088 CLAN009
APIS089 CLAN023
APIS095 CLAN006
APIS096 CLAN004
APIS097 CLAN005
APIS098 CLAN005
APIS099 CLAN006
APIS109 CLAN006
APIS110 CLAN004
APIS112 CLAN006
APIS114 CLAN044
APIS118 CLAN019
APIS121 CLAN010
APIS122 CLAN010
APIS123 CLAN006
APIS126 CLAN019
APIS127 CLAN004
APIS134 CLAN004
APIS137 CLAN010
APIS139 CLAN004
APIS144 CLAN010
APIS146 CLAN005
APIS147 CLAN005
APIS149 CLAN046
APIS154 CLAN006
APIS159 CLAN005
APIS162 CLAN019
APIS163 CLAN010
APIS169 CLAN006
APIS171 CLAN004
APIS172 CLAN006
APIS173 CLAN006
APIS175 CLAN004
APIS177 CLAN006
APIS182 CLAN004
APIS183 CLAN004
APIS184 CLAN004
APIS186 CLAN004
APIS187 CLAN005
APIS188 CLAN006
APIS189 CLAN010
APIS190 CLAN004
APIS196 CLAN006
APIS198 CLAN004
APIS199 CLAN006
APIS200 CLAN048
ardk ardk restriction-modification (RM) CLAN111 Plasmid pKM101 PMID: 8393008 ArdK and ArdR likely serve as ardKR-dependent regulatory system that controls the expression of ArdA and ArdB.
ardr ardr restriction-modification (RM) CLAN112 Plasmid pKM101 PMID: 8393008 ArdK and ArdR likely serve as ardKR-dependent regulatory system that controls the expression of ArdA and ArdB.
ardu ardu restriction-modification (RM) CLAN005 Shuttle vector pI3 PMID:10966401 The gene was from contructed E. coli-D. radiodurans shuttle vector,pI3, and trikingly similar to the known plasmid-encoded antirestriction proteins like ArdA.
ADG.17 ADG.17 toxin-antitoxin (TA) CLAN055 Sulfolobus monocaudavirus SMV1 PMID:38698035 ADG.17 and its homologs in archaea viruses act as antitoxins to inhibit host toxin Doc. It's the first example of an inhibitor of an archaeal toxin-antitoxin immune system.
APIS211 SequestinJ Thoeris CLAN001 PMID:41785351 Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation
APIS245 SequestinM Thoeris CLAN001 PMID:41785351 Sequestin-family anti-defense protein; inhibits type I Thoeris signaling, most likely by binding 3′cADPR.
APIS283 SequestinD Thoeris CLAN001 PMID:41785351 Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation
APIS283 SequestinE Thoeris CLAN001 PMID:41785351 Thoeris anti-defense sponge; sequesters 3′cADPR and blocks ThsA activation
APIS288 LockinE Type II Thoeris CLAN003 PMID:41785351 Lockin-family type II Thoeris inhibitor; expected to neutralize the type II Thoeris signal His-ADPR.
APIS288 LockinD Type I Thoeris,Type II Thoeris CLAN003 PMID:41785351 Lockin-family anti-defense sponge active against both type I and type II Thoeris; likely neutralizes 3′cADPR and His-ADPR immune signals.
APIS315 SequestinK Thoeris CLAN001 PMID:41785351 Sequestin-family Thoeris inhibitor; anti-defense protein that blocks the 3′cADPR → ThsA signaling pathway.
APIS315 SequestinB Thoeris CLAN001 PMID:41785351 Anti-Thoeris Sequestin-family sponge; neutralizes Thoeris signaling by trapping 3′cADPR and blocking downstream NAD-depletion defense.
APIS315 SequestinL Thoeris CLAN001 PMID:41785351 Viral anti-Thoeris sponge; binds/sequesters ADPR-derived Thoeris signal molecules and prevents growth-arrest/cell-death defense.
APIS315 SequestinH Thoeris CLAN001 PMID:41785351 Phage Sequestin homolog; functions as a Thoeris inhibitor by preventing immune-signal activation of the effector.
APIS315 SequestinF Thoeris CLAN001 PMID:41785351 Sequestin-family viral anti-defense protein; inhibits Thoeris by binding the TIR-produced ADPR-derived immune signal.
APIS356 SequestinI Thoeris CLAN001 PMID:41785351 Sequestin-family antidefense protein; neutralizes Thoeris signaling molecules and allows phage escape from Thoeris defense.
APIS359 LockinB Type I Thoeris CLAN003 PMID:41785351 Lockin-family type I Thoeris inhibitor; sponge protein that sequesters 3′cADPR, preventing Thoeris effector activation.
APIS361 Acb5B Type I CBASS CLAN002 PMID:41785351 cleaves cyclic guanosine monophosphate–adenosine monosphosphate (3′3′-cGaMP) and related molecules
APIS372 SequestinC Thoeris CLAN001 PMID:41785351 Small phage anti-defense protein from the Sequestin family; inhibits type I Thoeris by interfering with 3′cADPR-mediated immune activation.
APIS373 SequestinG Thoeris CLAN001 PMID:41785351 Anti-Thoeris sponge protein; blocks Thoeris immune signaling, likely through sequestration of 3′cADPR.
APIS378 SequestinA Thoeris CLAN001 PMID:41785351 Phage-encoded anti-Thoeris sponge protein; binds/sequesters the type I Thoeris immune signal 3′cADPR, preventing activation of the ThsA NADase effector.
LockinC LockinC Type I Thoeris CLAN003 PMID:41785351 Lockin-family sponge protein; inhibits type I Thoeris by trapping 3′cADPR.
APIS201 CLAN012
APIS202 CLAN002
APIS203 CLAN001
APIS205 CLAN001
APIS206 CLAN012
APIS208 CLAN032
APIS209 CLAN013
APIS210 CLAN002
APIS212 CLAN021
APIS214 CLAN014
APIS215 CLAN028
APIS216 CLAN002
APIS217 CLAN012
APIS218 CLAN002
APIS219 CLAN015
APIS220 CLAN003
APIS221 CLAN001
APIS222 CLAN012
APIS223 CLAN002
APIS225 CLAN002
APIS226 CLAN003
APIS227 CLAN001
APIS228 CLAN003
APIS229 CLAN002
APIS230 CLAN001
APIS231 CLAN007
APIS232 CLAN015
APIS233 CLAN013
APIS234 CLAN003
APIS235 CLAN007
APIS236 CLAN013
APIS237 CLAN049
APIS238 CLAN016
APIS239 CLAN028
APIS241 CLAN016
APIS243 CLAN014
APIS246 CLAN003
APIS247 CLAN001
APIS248 CLAN003
APIS249 CLAN015
APIS250 CLAN021
APIS251 CLAN051
APIS252 CLAN001
APIS253 CLAN014
APIS254 CLAN001
APIS255 CLAN002
APIS256 CLAN001
APIS257 CLAN007
APIS259 CLAN007
APIS260 CLAN002
APIS261 CLAN052
APIS262 CLAN022
APIS263 CLAN013
APIS264 CLAN007
APIS266 CLAN003
APIS267 CLAN002
APIS268 CLAN001
APIS271 CLAN001
APIS272 CLAN003
APIS273 CLAN013
APIS274 CLAN013
APIS275 CLAN013
APIS277 CLAN016
APIS278 CLAN007
APIS280 CLAN001
APIS284 CLAN003
APIS285 CLAN003
APIS289 CLAN050
APIS290 CLAN003
APIS291 CLAN002
APIS295 CLAN014
APIS296 CLAN015
APIS298 CLAN012
APIS299 CLAN003
APIS300 CLAN034
APIS301 CLAN002
APIS302 CLAN001
APIS303 CLAN003
APIS304 CLAN003
APIS305 CLAN032
APIS306 CLAN001
APIS309 CLAN007
APIS310 CLAN001
APIS311 CLAN012
APIS313 CLAN003
APIS314 CLAN034
APIS316 CLAN007
APIS317 CLAN002
APIS318 CLAN001
APIS319 CLAN015
APIS320 CLAN021
APIS321 CLAN003
APIS322 CLAN035
APIS323 CLAN001
APIS324 CLAN053
APIS326 CLAN016
APIS327 CLAN001
APIS328 CLAN002
APIS329 CLAN033
APIS330 CLAN014
APIS331 CLAN001
APIS332 CLAN001
APIS333 CLAN001
APIS334 CLAN001
APIS335 CLAN003
APIS336 CLAN035
APIS337 CLAN002
APIS338 CLAN002
APIS339 CLAN002
APIS340 CLAN002
APIS341 CLAN001
APIS342 CLAN014
APIS343 CLAN002
APIS344 CLAN001
APIS346 CLAN012
APIS347 CLAN016
APIS348 CLAN002
APIS349 CLAN007
APIS350 CLAN007
APIS352 CLAN022
APIS353 CLAN001
APIS357 CLAN017
APIS358 CLAN003
APIS360 CLAN001
APIS362 CLAN001
APIS364 CLAN003
APIS365 CLAN007
APIS366 CLAN033
APIS367 CLAN002
APIS368 CLAN022
APIS370 CLAN003
APIS371 CLAN001
APIS374 CLAN001
APIS375 CLAN022
APIS376 CLAN016
APIS377 CLAN015
APIS379 CLAN028
APIS380 CLAN054
APIS381 CLAN002