Browse anti-prokaryotic immune system families by Host order

AD families AD genes Defense system CLAN ID Phages/MGEs References Description
APIS004 Acb2 cyclic oligonucleotide-based antiphage signaling system (CBASS) CLAN036 PaMx33 of Pseudomonas aeruginosa PMID:36750095 Anti-CBASS protein ("Acb2") that forms a hexamer with three 3',3'-cGAMP molecules and reduces phospholipase activity.
APIS055 CLAN011 Pseudomonas phage Churro
APIS079 CLAN001 Pseudomonas phage Skulduggery
APIS116 CLAN025
APIS174 CLAN027
APIS191 CLAN025
APIS293 ZadI-1 Zorya type I CLAN097 Pseudomonas phage vB_PaeM_SMS12 PMID:40639337 ZadI-1 inhibits Zorya type I defense, as shown by efficiency of plating, culture collapse,and phage propagation assays
APIS297 Bdi1 Zorya type I,RADAR,Hypnos,Druantia type I CLAN098 Pseudomonas phage PB1 PMID:40639337 Bdi1 and Bdi2 function as multipurpose anti-defense proteins capable of inhibiting four defense systems.
TadIII-1 TadIII-1 Thoeris type III CLAN108 Pseudomonas phage S50 PMID:40639337 TadIII-1 inhibits the anti-phage activity of Thoeris type III by a yet unknown mechanism
DadIII-1 DadIII-1 Druantia type III CLAN105 Pseudomonas phage PA_LZ7 PMID:40639337 DadIII-1 inhibits Druantia type III, most likely through a mechanism specifically targeting the activity of DruH, a protein unique to this Druantia type
Bdi2 Bdi2 Zorya type I,RADAR,Hypnos,Druantia type I CLAN104 Pseudomonas phage JG024 PMID:40639337 Bdi1 and Bdi2 function as multipurpose anti-defense proteins capable of inhibiting four defense systems.
APIS292 dap1 Lon-mediated antiviral defense CLAN096 Pseudomonas phage PaoP5 PMID:38886583 Dap1 directly binds to phage HNH endonuclease, prohibiting host Lon-mediated HNH degradation and promoting phage genome packaging.
dap2 dap2 Lon-mediated antiviral defence CLAN051 Pseudomonas phage PaoP5 Zhao et al., 2025 Dap2 directly binds to the Lon protease to prevent the degradation of the phage-encoded HNH endonuclease.