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Basic Information | |
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Species | Brassica rapa |
Cazyme ID | Bra038124 |
Family | CBM57 |
Protein Properties | Length: 1020 Molecular Weight: 112971 Isoelectric Point: 5.5851 |
Chromosome | Chromosome/Scaffold: 05 Start: 10318226 End: 10324368 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
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NCBI Taxonomy |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 392 | 573 | 1.1e-23 |
INCGGEAVEVGKDTYEEDLNNKGASIFMPVSDRWGYSSSGTWIGDDGVPYLATDERFNLLNESVPQYYKRARLAPQSLKYYGRCLRSESYKLQLHFAEIM FSNDQTYSSIGRRVFDIYVQGNLLVKDFNIAERAGGVGKPFTLQIDRVQVNGSTLEVHLLWSGKGTNVLPQRGVYGPLISAI |
Full Sequence |
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Protein Sequence Length: 1020 Download |
MSCFILSAEK VMNVLLFIAI LFGIFGSNAQ LLPDDEVQTL RTIFAKLQHR PVNIERTSCS 60 DRNSNFTSGE GNRTIICDCT VNSTCHVTRI FLKSLSLPGI FPPEFGNLTR LLEIDLSRNY 120 LNGTIPMTLS RTPLEILSVT GNRLSGPIPP QLGDVTTLTN LNLESNLLSG PIPSSLGSLT 180 SLKSLLLSAN NFTGQLPQPL INLKNLTNFR IDGNSLSGKI PEFIGNWTQL DRLDLQGTSM 240 SGPIPASISN LRNLTELRIT DLNGPAFDFP DLRNLINIKR LVLRNCLIRG RIPDYIGSMI 300 ELKTLDLSSN LLTGPIPDTF RDLDYNFMFL SNNSLSGQLP QFIIDSKDSV DLSYNNFTQA 360 PSLSCSMPDI VQWCLRRDLP CPTEAKHSSL FINCGGEAVE VGKDTYEEDL NNKGASIFMP 420 VSDRWGYSSS GTWIGDDGVP YLATDERFNL LNESVPQYYK RARLAPQSLK YYGRCLRSES 480 YKLQLHFAEI MFSNDQTYSS IGRRVFDIYV QGNLLVKDFN IAERAGGVGK PFTLQIDRVQ 540 VNGSTLEVHL LWSGKGTNVL PQRGVYGPLI SAITITPNYK VDDGKPLSNG AVAGIVVAAC 600 AVFAFLVLLI LRLTGYLGRK EEDDNEELRG LDLQTGSFTL KQIKRATNNF DPENKIGEGG 660 FGPVYKGVLG DGTTIAVKQL SSKSKQGNRE FVTEIGMISA LQHPNLVKLY GCCIEGKELL 720 LVYEYLENNS LARALFGSEK QRLHLDWATR NKICIGIAKG LAYLHEESRL KIVHRDIKAT 780 NVLLDQSLNA KISDFGLAKL DEEENTHIST RIAGTIGYMA PEYAMRGYLT DKADVYSFGV 840 VCLEIVSGKS NTNYRPKEEF VYLLDWAYVL QEQGNLLELV DMDLGTNFSK KEAKRMLNIA 900 LLCTNPSPTL RPPMSSVVSM LEGKIKVEPP LVKREADPTG AAAMRFRAFE LLSQDSESQA 960 STFERDREQK SSSSMDGPWV DSSFSAPGKD GNVKQEEEEE RSSSSSRKLL DELTEVKVE* 1020 1080 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam07714 | Pkinase_Tyr | 3.0e-42 | 655 | 921 | 286 | + Protein tyrosine kinase. | ||
cd00192 | PTKc | 3.0e-44 | 654 | 922 | 284 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
smart00221 | STYKc | 7.0e-45 | 653 | 921 | 286 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
smart00219 | TyrKc | 1.0e-45 | 653 | 921 | 280 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
pfam11721 | Malectin | 2.0e-46 | 389 | 573 | 187 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAF78445.1 | 0 | 4 | 998 | 3 | 959 | AC018748_24 Contains a weak similarity to disease resistance protein (cf-5) gene from Lycopersicon esculentum gb |
Swiss-Prot | C0LGG8 | 0 | 4 | 1019 | 3 | 1038 | Y5343_ARATH RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g53430; Flags: Precursor |
RefSeq | NP_001117479.1 | 0 | 37 | 1019 | 3 | 997 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
RefSeq | NP_175748.1 | 0 | 4 | 1019 | 3 | 1030 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
RefSeq | NP_175749.1 | 0 | 4 | 998 | 3 | 1015 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 634 | 923 | 16 | 308 | A Chain A, Ydhf, An Aldo-keto Reductase From E.coli Complexed With Nadph |
PDB | 3uim_A | 0 | 634 | 923 | 16 | 308 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 634 | 923 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 634 | 923 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 634 | 923 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |