dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000004680_01963

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Lacrimispora;

CAZyme ID

MGYG000004680_01963

CAZy Family

GH126

CAZyme Description

Thiol-disulfide oxidoreductase ResA

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
545	MGYG000004680_25\|CGC1	62028.65	4.8002

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004680	3596809	MAG	Germany	Europe

Gene Location

Start: 23995; End: 25632 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000004680_01963.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH126	227	541	5.7e-84	0.9906542056074766

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd02966	TlpA_like_family	3.84e-24	84	199	1	112	TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.
pfam00578	AhpC-TSA	1.69e-14	78	199	1	123	AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).
COG0526	TrxA	1.11e-12	82	199	12	125	Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones].
cd03010	TlpA_like_DsbE	5.76e-12	93	198	16	114	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c maturation (Ccm) factor with a redox active CXXC motif. Assembly of cytochrome c requires the ligation of heme to reduced thiols of the apocytochrome. In bacteria, this assembly occurs in the periplasm. The reductase activity of DsbE in the oxidizing environment of the periplasm is crucial in the maturation of cytochrome c.
pfam08534	Redoxin	1.30e-09	79	198	3	129	Redoxin. This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCN29944.1	3.89e-190	62	541	59	538
QSX01740.1	8.33e-115	67	541	45	516
QUF82251.1	8.33e-115	67	541	45	516
QJU43754.1	8.33e-115	67	541	45	516
AXB84457.1	9.68e-115	67	541	50	521

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3REN_A	3.03e-48	228	542	28	346	CPF_2247,a novel alpha-amylase from Clostridium perfringens [Clostridium perfringens],3REN_B CPF_2247, a novel alpha-amylase from Clostridium perfringens [Clostridium perfringens]
5UM7_A	2.82e-19	74	193	46	163	Crystalstructure of the reduced state of the thiol-disulfide reductase SdbA from Streptococcus gordonii [Streptococcus gordonii str. Challis substr. CH1],5UM7_B Crystal structure of the reduced state of the thiol-disulfide reductase SdbA from Streptococcus gordonii [Streptococcus gordonii str. Challis substr. CH1]
2YP6_A	2.68e-11	83	197	50	164	Crystalstructure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with Cyclofos 3 TM [Streptococcus pneumoniae TIGR4],2YP6_B Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with Cyclofos 3 TM [Streptococcus pneumoniae TIGR4],2YP6_C Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with Cyclofos 3 TM [Streptococcus pneumoniae TIGR4],2YP6_D Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with Cyclofos 3 TM [Streptococcus pneumoniae TIGR4]
4HQZ_A	2.78e-11	83	197	52	166	Crystalstructure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with 2-hydroxyethyl disulfide [Streptococcus pneumoniae TIGR4],4HQZ_B Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with 2-hydroxyethyl disulfide [Streptococcus pneumoniae TIGR4]
1JFU_A	4.23e-10	81	195	39	154	CrystalStructure Of The Soluble Domain Of Tlpa From Bradyrhizobium Japonicum [Bradyrhizobium japonicum],1JFU_B Crystal Structure Of The Soluble Domain Of Tlpa From Bradyrhizobium Japonicum [Bradyrhizobium japonicum]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O31486	4.23e-23	229	540	47	351	Putative lipoprotein YdaJ OS=Bacillus subtilis (strain 168) OX=224308 GN=ydaJ PE=3 SV=1
Q6HL81	1.57e-10	74	216	33	169	Thiol-disulfide oxidoreductase ResA OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) OX=281309 GN=resA PE=3 SV=1
Q73B22	1.57e-10	74	216	33	169	Thiol-disulfide oxidoreductase ResA OS=Bacillus cereus (strain ATCC 10987 / NRS 248) OX=222523 GN=resA PE=3 SV=1
Q9KCJ4	2.62e-09	88	212	48	167	Thiol-disulfide oxidoreductase ResA OS=Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) OX=272558 GN=resA PE=3 SV=1
P43221	4.07e-09	81	195	74	189	Thiol:disulfide interchange protein TlpA OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) OX=224911 GN=tlpA PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.989807	0.009290	0.000085	0.000086	0.000038	0.000716

TMHMM Annotations download full data without filtering help

start	end
13	35