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CAZyme Information: MGYG000004599_01592

You are here: Home > Sequence: MGYG000004599_01592

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Phocaeicola;
CAZyme ID MGYG000004599_01592
CAZy Family PL8
CAZyme Description Chondroitinase-AC
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
729 MGYG000004599_41|CGC1 82116.41 4.9617
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004599 3450206 MAG France Europe
Gene Location Start: 19780;  End: 21969  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004599_01592.

CAZyme Signature Domains help

Family Start End Evalue family coverage
PL8 361 614 1.5e-87 0.9959839357429718

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd01083 GAG_Lyase 8.16e-153 44 688 1 693
Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.
pfam02278 Lyase_8 7.79e-88 361 614 1 251
Polysaccharide lyase family 8, super-sandwich domain. This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
pfam08124 Lyase_8_N 3.46e-62 66 351 22 323
Polysaccharide lyase family 8, N terminal alpha-helical domain. This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
pfam02884 Lyase_8_C 3.58e-18 630 696 1 67
Polysaccharide lyase family 8, C-terminal beta-sandwich domain. This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
ASM65495.1 7.77e-173 69 698 58 689
QQT77967.1 7.77e-173 69 698 58 689
QUU07408.1 7.77e-173 69 698 58 689
QRP56789.1 7.77e-173 69 698 58 689
QDO70900.1 1.88e-172 1 728 1 715

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1CB8_A 2.11e-139 66 721 21 674
CHONDROITINASEAC LYASE FROM FLAVOBACTERIUM HEPARINUM [Pedobacter heparinus]
1HM2_A 4.01e-139 66 721 43 696
ACTIVESITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS [Pedobacter heparinus],1HM3_A Active Site Of Chondroitinase Ac Lyase Revealed By The Structure Of Enzyme-Oligosaccharide Complexes And Mutagenesis [Pedobacter heparinus],1HMU_A ACTIVE SITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS [Pedobacter heparinus],1HMW_A Active Site Of Chondroitinase Ac Lyase Revealed By The Structure Of Enzyme-oligosaccharide Complexes And Mutagenesis [Pedobacter heparinus]
2E24_A 5.04e-34 100 729 66 738
ChainA, Xanthan lyase [Bacillus sp. GL1]
2E22_A 8.94e-34 100 729 66 738
Crystalstructure of xanthan lyase in complex with mannose [Bacillus sp. GL1]
1J0M_A 2.11e-33 100 729 66 738
CrystalStructure of Bacillus sp. GL1 Xanthan Lyase that Acts on Side Chains of Xanthan [Bacillus sp. GL1],1J0N_A Crystal Structure of Bacillus sp. GL1 Xanthan Lyase that Acts on Side Chains of Xanthan [Bacillus sp. GL1]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q59288 2.20e-138 66 721 43 696
Chondroitinase-AC OS=Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) OX=485917 GN=cslA PE=1 SV=1
Q9AQS0 7.43e-33 100 729 91 763
Xanthan lyase OS=Bacillus sp. (strain GL1) OX=84635 GN=xly PE=1 SV=1
Q54873 1.31e-25 106 652 360 957
Hyaluronate lyase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=SP_0314 PE=1 SV=2
Q53591 2.82e-25 146 644 368 930
Hyaluronate lyase OS=Streptococcus agalactiae serotype III (strain NEM316) OX=211110 GN=hylB PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000475 0.225891 0.773330 0.000110 0.000097 0.000088

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004599_01592.