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CAZyme Information: MGYG000004585_01161

You are here: Home > Sequence: MGYG000004585_01161

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Methanobacterium sp000499765
Lineage Archaea; Methanobacteriota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanobacterium; Methanobacterium sp000499765
CAZyme ID MGYG000004585_01161
CAZy Family GT2
CAZyme Description Acetyl-coenzyme A synthetase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
634 MGYG000004585_9|CGC2 71963.63 5.7142
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004585 1905101 MAG France Europe
Gene Location Start: 66365;  End: 68269  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004585_01161.

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PLN02654 PLN02654 0.0 6 634 5 653
acetate-CoA ligase
PRK10524 prpE 0.0 39 633 14 615
propionyl-CoA synthetase; Provisional
cd05966 ACS 0.0 38 634 12 608
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme). Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
cd05967 PrpE 0.0 38 634 10 610
Propionyl-CoA synthetase (PrpE). EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
PRK04319 PRK04319 0.0 57 633 27 569
acetyl-CoA synthetase; Provisional

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CAE6201330.1 3.00e-188 43 632 596 1200
CAE6201338.1 3.94e-188 43 632 607 1211
QND46664.1 9.95e-32 106 619 2095 2578
BAZ75991.1 9.84e-31 62 631 559 1093
BAZ00088.1 9.84e-31 62 631 559 1093

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2P2F_A 5.23e-198 39 632 34 632
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
5JRH_A 6.83e-198 39 632 34 632
Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
2P2M_A 1.49e-197 39 632 34 632
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
2P2B_A 2.10e-197 39 632 34 632
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2B_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
2P2Q_A 2.98e-197 39 632 34 632
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A0B8F1 5.18e-248 5 632 7 646
Acetyl-coenzyme A synthetase OS=Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) OX=349307 GN=acsA PE=1 SV=1
Q72J95 7.62e-245 8 634 7 637
Acetyl-coenzyme A synthetase OS=Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) OX=262724 GN=acsA PE=3 SV=1
Q5SIW6 1.08e-244 8 634 7 637
Acetyl-coenzyme A synthetase OS=Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) OX=300852 GN=acsA PE=3 SV=1
Q8KBY0 9.09e-239 8 634 17 645
Acetyl-coenzyme A synthetase OS=Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) OX=194439 GN=acsA PE=3 SV=2
Q8DKH2 3.08e-236 8 634 9 645
Acetyl-coenzyme A synthetase OS=Thermosynechococcus vestitus (strain IAM M-273 / NIES-2133 / BP-1) OX=197221 GN=acsA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000034 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004585_01161.