CAZyme Information: MGYG000004205_01294

Basic Information

• Species: RC9 sp900546445
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; UBA932; RC9; RC9 sp900546445
• CAZyme ID: MGYG000004205_01294
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
376		42501.13	8.3834

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004205	1871322	MAG	United Kingdom	Europe

• Gene Location: Start: 12136; End: 13266 Strand: +

Full Sequence      

MKYFLIAGEASGDLHASNLMKGLLAEDPEADFRFWGGDKMASVGGTLLHHYKEGAVMGVG
DVFSKAGMLLHNIKECKDNILSYAPDVVILIDYPGFNMKMAKFAHKKHIKVFYYIAPKTW
ASRSWRNRSLKRYVDMLYIVFPFEIPYFTKQGIPFVYKGNPLVEAIDNAHFEKVCDSDYI
AVLPGSRKGEISRTLPLCVELADKMHADARYSGYKFVIAGAPARDISDYSPYLKGREDYV
RVVFDKTYSVIKGARAAIVNSGTASLETVLLGTPHMVCWSTSPFTAFVARYILRVMDKIK
YVSLGNLIVDELVFKEFIQEDFNLRNISDEMDRLLGDETYRAEMLEGYERIRKALGQGNA
SRAFALDMIARLSESR

Enzyme Prediction     

No EC number prediction in MGYG000004205_01294.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	356	5.1e-101	0.9915254237288136

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	3.04e-98	1	363	2	367	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	2.89e-97	1	365	2	372	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	1.09e-73	4	363	2	366	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	2.36e-58	5	368	10	383	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	1.69e-51	1	362	2	339	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AGY53532.1	3.88e-113	1	372	1	370
ANW95466.1	9.13e-103	1	365	1	362
AII64873.1	9.46e-103	1	374	1	379
AND19645.1	9.46e-103	1	374	1	379
QJR71433.1	9.46e-103	1	374	1	379

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	5.04e-28	5	321	11	331	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	5.04e-28	5	321	11	331	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q39T49	1.60e-67	2	376	8	384	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
B3E4H8	2.66e-65	2	375	8	383	Lipid-A-disaccharide synthase OS=Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) OX=398767 GN=lpxB PE=3 SV=1
Q74AT9	7.63e-65	2	371	8	382	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1
Q3JAC1	1.07e-57	5	372	10	378	Lipid-A-disaccharide synthase OS=Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107) OX=323261 GN=lpxB PE=3 SV=1
Q1D393	4.09e-56	2	376	6	382	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000066	0.000005	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000004205_01294.