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CAZyme Information: MGYG000004174_01119

You are here: Home > Sequence: MGYG000004174_01119

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-74; Firm-11;
CAZyme ID MGYG000004174_01119
CAZy Family GH33
CAZyme Description Hercynine oxygenase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
658 MGYG000004174_30|CGC1 73908.01 6.5346
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000004174 2366989 MAG United Kingdom Europe
Gene Location Start: 11928;  End: 13904  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000004174_01119.

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG1262 YfmG 3.61e-53 2 233 40 312
Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones].
pfam03781 FGE-sulfatase 4.64e-43 17 231 7 258
Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.
cd15482 Sialidase_non-viral 8.04e-22 287 635 11 321
Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088 BNR_2 9.10e-22 301 634 1 280
BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
ADV43483.1 1.23e-180 17 648 31 641
ARN56721.1 9.86e-180 5 648 32 678
QQR10361.1 2.20e-179 18 651 24 656
ASB36855.1 2.58e-179 18 651 29 661
ANU62655.1 2.58e-179 18 651 29 661

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6MUJ_A 9.96e-25 17 234 33 308
Formylglycinegenerating enzyme bound to copper [Streptomyces coelicolor A3(2)],6MUJ_B Formylglycine generating enzyme bound to copper [Streptomyces coelicolor A3(2)],6MUJ_C Formylglycine generating enzyme bound to copper [Streptomyces coelicolor A3(2)],6MUJ_D Formylglycine generating enzyme bound to copper [Streptomyces coelicolor A3(2)],6MUJ_E Formylglycine generating enzyme bound to copper [Streptomyces coelicolor A3(2)]
2Q17_A 1.57e-24 17 234 60 335
FormylglycineGenerating Enzyme from Streptomyces coelicolor [Streptomyces coelicolor A3(2)],2Q17_B Formylglycine Generating Enzyme from Streptomyces coelicolor [Streptomyces coelicolor A3(2)],2Q17_C Formylglycine Generating Enzyme from Streptomyces coelicolor [Streptomyces coelicolor A3(2)],2Q17_D Formylglycine Generating Enzyme from Streptomyces coelicolor [Streptomyces coelicolor A3(2)],2Q17_E Formylglycine Generating Enzyme from Streptomyces coelicolor [Streptomyces coelicolor A3(2)]
2AFT_X 7.16e-20 18 229 9 279
ChainX, Sulfatase modifying factor 1 [Homo sapiens],2AIJ_X Chain X, Sulfatase modifying factor 1 [Homo sapiens],2AIK_X Chain X, Sulfatase modifying factor 1 [Homo sapiens],2HI8_X Chain X, Sulfatase-modifying factor 1 [Homo sapiens],2HIB_X Chain X, Sulfatase-modifying factor 1 [Homo sapiens]
5NXL_A 9.04e-20 18 237 20 299
Formylglycinegenerating enzyme from T. curvata in complex with Ag(I) [Thermomonospora curvata DSM 43183],5NYY_A Formylglycine generating enzyme from T. curvata in complex with Cd(II) [Thermomonospora curvata DSM 43183]
6S07_A 9.49e-20 18 237 24 303
Structureof formylglycine-generating enzyme at 1.04 A in complex with copper and substrate reveals an acidic pocket for binding and acti-vation of molecular oxygen. [Thermomonospora curvata DSM 43183],6XTL_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTM_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTN_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTO_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTP_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTQ_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTR_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183],6XTS_A Chain A, Formylglycine-generating enzyme [Thermomonospora curvata DSM 43183]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q7AJA5 1.29e-24 18 229 388 613
Serine/threonine-protein kinase pkn1 OS=Chlamydia pneumoniae OX=83558 GN=pkn1 PE=3 SV=1
P0DPS7 2.23e-24 12 229 379 608
Serine/threonine-protein kinase Pkn1 OS=Chlamydia trachomatis (strain D/UW-3/Cx) OX=272561 GN=pkn1 PE=3 SV=1
A0A0H3MBJ2 2.23e-24 12 229 379 608
Serine/threonine-protein kinase Pkn1 OS=Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) OX=471472 GN=pkn1 PE=1 SV=1
Q9F3C7 4.98e-24 17 234 28 303
Formylglycine-generating enzyme OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) OX=100226 GN=SCO7548 PE=1 SV=1
Q822R1 5.33e-24 12 229 383 612
Serine/threonine-protein kinase pkn1 OS=Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC) OX=227941 GN=pkn1 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000055 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000004174_01119.