CAZyme Information: MGYG000003905_00305

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Flavobacteriales; UBA1820; UBA1820
• CAZyme ID: MGYG000003905_00305
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
379	MGYG000003905_2|CGC1	42622.38	9.2942

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003905	1618825	MAG	China	Asia

• Gene Location: Start: 131863; End: 133002 Strand: -

Full Sequence      

MKYYIIAGEASGDLHGSNLVRALQDADPQARIRAWGGDLMQQAGAEVVKHYRDLAFMGFV
EVVANLRTILRNIRFCKQDIEAFAPDAVILVDYPGFNLRIAKWCRQKGYRTVYYISPQVW
AWKEGRVKAIRRNVDRMLVILPFEKDFYLRHRYPVEYVGHPLLDALARRSAPDPEVFRRE
EGLDGRPVVALLPGSRSQEIRAMLPVMARMAEVYPEYQFVVAATPVQPGELYDRLLASRP
IKRVTGRTYDLLSVSHAALVTSGTATLETALLGIPEVVCYKGSPVSYLIGRMVVKVPFIS
LVNLIAGREVVKELIQGAMNPRNLSRELGRILSGQAREKMLEDFASIRHLLGDGGASQRA
AEAIVGFLHQEEDQQTECR

Enzyme Prediction     

No EC number prediction in MGYG000003905_00305.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	351	1.1e-126	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	6.41e-140	1	372	2	379	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	8.68e-123	1	368	2	379	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	8.30e-92	4	363	2	370	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	6.28e-82	5	367	10	385	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	6.54e-59	52	357	46	338	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QEE49237.1	3.11e-165	1	368	1	369
AXG73350.1	1.93e-163	1	368	1	369
QYJ69419.1	3.17e-162	1	365	1	366
AIP99513.1	4.85e-161	1	365	1	365
AFL96694.1	4.85e-161	1	365	1	365

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	3.71e-58	5	365	11	378	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	7.33e-58	5	365	11	378	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q2LVL8	3.02e-90	5	361	8	371	Lipid-A-disaccharide synthase OS=Syntrophus aciditrophicus (strain SB) OX=56780 GN=lpxB PE=3 SV=1
Q74AT9	5.59e-88	2	368	8	380	Lipid-A-disaccharide synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) OX=243231 GN=lpxB PE=3 SV=1
Q1D393	2.18e-84	2	368	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q39T49	1.78e-83	2	368	8	380	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1
B3E4H8	5.47e-82	2	370	8	382	Lipid-A-disaccharide synthase OS=Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) OX=398767 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000058	0.000006	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003905_00305.