CAZyme Information: MGYG000003837_00958

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas
• CAZyme ID: MGYG000003837_00958
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
378	MGYG000003837_16|CGC1	41769.27	8.1208

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003837	2173953	MAG	United States	North America

• Gene Location: Start: 39144; End: 40280 Strand: -

Full Sequence      

MKYLLIAGEASGDEHGARLIASLKAVDAKAAFAFIGGDKMAQQAGVAPLYHYHEIAVMGF
TSVLRSMSKIRLAARLLQEELRSNPPDVVIPIDYGGFNLRYTLPMAHRHGVPVVYYIPPK
VWASRRRRIKRLRSYTDLCLTILPFEADYLSQRGVNARYVGNPSIQSVGELLDSNAKLCD
TARPYIALLPGSREAEIARNLPIMCRAIDLLPAPWRAVIAGAPSIDPAHYTPYLSERIEL
VIDETLPLLAGASAALVTSGTATLETALIGTPQVVAYRLPAGCLARWAFDHILPIRYFSL
VNLIAESPVVEELLGDAVTPQRLVQALTPLLDRESTAYQTQQAQYRMVRQRLEPSRVASQ
VAAERIYHELSTQWESEA

Enzyme Prediction     

No EC number prediction in MGYG000003837_00958.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	352	1.1e-97	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	1.11e-90	1	364	2	373	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	2.69e-86	1	372	2	381	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	3.48e-67	4	356	2	363	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	3.36e-58	4	363	9	380	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	1.12e-42	1	326	2	312	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AEE12174.1	5.02e-256	1	377	1	377
SQH73726.1	1.59e-99	1	331	1	338
QUB42945.1	4.94e-94	1	323	1	326
ATS09476.1	1.83e-90	1	349	1	353
ATS02318.1	2.59e-90	1	349	1	353

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	9.47e-38	5	338	11	352	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	9.47e-38	5	338	11	352	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	4.66e-55	2	325	6	335	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q6ALW0	1.95e-54	4	331	13	350	Lipid-A-disaccharide synthase OS=Desulfotalea psychrophila (strain LSv54 / DSM 12343) OX=177439 GN=lpxB PE=3 SV=1
B6J9H1	6.79e-52	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuK_Q154) OX=434924 GN=lpxB PE=3 SV=1
B6J161	6.79e-52	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuG_Q212) OX=434923 GN=lpxB PE=3 SV=1
A9KC41	6.79e-52	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain Dugway 5J108-111) OX=434922 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000051	0.000002	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000003837_00958.