CAZyme Information: MGYG000003013_00993

Basic Information

• Species: Oribacterium sinus
• Lineage: Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Oribacterium; Oribacterium sinus
• CAZyme ID: MGYG000003013_00993
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
910	MGYG000003013_19|CGC1	102616.29	5.4629

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003013	2494431	MAG	United States	North America

• Gene Location: Start: 17080; End: 19812 Strand: +

Full Sequence      

MGREIREGERGHKRGKKKSSAFRFIRRLFLGSVLFLFVLSVLGYVIFIRPEVNRLRGIAY
DKLAGSNLKDLTKRADTVVFDTDGQQLGTINAGHFVYDKIEDISPNLQNAYIAQEDRNFK
THHGVDYKATLRAVFQLVKNRGRITQGGSTITQQVVKNTYLSQEKTFTRKIVEIMLAQEL
EKMYSKADIMEIYCNTNFYGNNCYGVEAASQYYFEKPAKDLTVEEAAMLAGISNAPSRYE
PVRHPDLALKKRNQVLKSMETVGYITEAEYEEAIGKPLQISQNVQKGTDEDYMNSYALYA
ATIRMMEVNKFPFTYHFETQADKEAYQDQYEEQYNFYNRELRAGGYKIYTSLDPKIQNIL
QETLDKGLSKFQEVQENGKLSMQGAGVIIDNKTGYVVATVGGRGTEDKYNRAYLSYRQPG
SAIKPLLDYAPALDLGEYNAASVIDDHKFENGPSNSGDNYYGAVTMREAANRSLNTVAWQ
ILDGIGIQNGLDYLEKMHFSGISVKDNDALAVSIGGFTNGLRVVDMAKGYSTLANGGVYS
NKTCILKIESDKDGVVADEKTIQNTQVFREDTAFIMTDILKGTMNTEYGTGRGLQLKNKM
PAAGKTGTSNGSKDTWFCGYTKYYSAAIWVGHDMPVEMPGIYGATYAGKIWKNTMDILHE
DLEPEDWEVPDTVVKEADEKSGITDYVSKTAKQRGEENRKKKAEKETKAQIEKDIKTYEA
MKIQKLEDVFTARTLFGKIRDSLNDITDEKFKKEYQERLFTKQKEFLVIEDKWKDEIDAY
IAKKEEESRVQESIAESKAKEAEEKAQKNAKRESFLSALTGLQSLEYRDGDTEALINDAI
ERLQELNGSEDYYSLSQQLDAAIRRVRSLPKKEEETLESKSGEGSPFYSGPGPGNYLGER
DSNNGPGVSP

Enzyme Prediction     

No EC number prediction in MGYG000003013_00993.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	84	260	1.6e-64	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	4.00e-176	96	661	3	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.66e-172	14	695	4	636	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	2.36e-142	25	683	4	744	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	3.52e-92	107	659	159	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	5.06e-92	59	658	20	561	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QIX92626.1	7.21e-309	48	874	56	882
QQQ98855.1	2.34e-307	48	883	56	894
ANU46427.1	2.34e-307	48	883	56	894
QRP41393.1	5.22e-301	48	883	56	894
ASN93939.1	5.22e-301	48	883	56	894

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	2.65e-72	68	661	12	725	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	5.65e-65	79	655	23	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	5.34e-64	178	633	1	433	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3DWK_A	8.59e-63	79	631	10	556	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	3.85e-60	79	631	19	565	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P40750	4.52e-99	27	655	5	620	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
A7FY32	2.13e-91	11	674	2	659	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	2.13e-91	11	674	2	659	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
A7GHV1	1.03e-90	11	674	2	659	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
P38050	1.72e-89	69	655	41	594	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000027	0.000011	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
24	46