CAZyme Information: MGYG000002943_02124

Basic Information

• Species: Actinomyces oris
• Lineage: Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Actinomycetaceae; Actinomyces; Actinomyces oris
• CAZyme ID: MGYG000002943_02124
• CAZy Family: GT2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
514	MGYG000002943_179|CGC1	57614.95	10.2328

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002943	3026158	MAG	United States	North America

• Gene Location: Start: 2363; End: 3907 Strand: -

Full Sequence      

MTWSFGPLVLLICLVILLACFAVKLLFKRGTRLRAVRAVHRREGHGERRGTGRGGVVTVR
TPVTTPDEAQRSADATGLPRALMRAGGPLPAVVVALGVVGWLCWRVLVSRHHVLDAWIVW
TFDVLFVIVAVQLVVAGFEGRVIGRGEAHRVAVLVPLYNEDPDVVVRMLSALLHQSAPPA
EIHVVDDGSTQGAYVEERDWFIRQAALTGIYASWQRTPNEGKRHAQVHGFRKIRDADLFV
TVDSDSMLDAEALHEIVQPFSDPRVMSVAGVILAINNRENLLARVTDVIFVGQQLIDRSF
MSQLGSVMVNSGGLAAYRCSILAENIDTYLNESYLGRHVEFSDDSLLTLFALLHGRTVQQ
PSAFAFAWMPDRWSHHYRQQERWFRGSFIRGLWRIRFLPVLSWGWWRQATGWMQIWLVIS
VFVYLLLWRPLVLGGGVPPTVVLVPLAIGLAQGSRYISVWRSDTTGPQRYASLLLSPVAT
LWSALILRPLRVWGMVTSAKMGWNTRQQVEVTSQ

Enzyme Prediction     

No EC number prediction in MGYG000002943_02124.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT2	150	386	2.2e-20	0.991304347826087

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd06434	GT2_HAS	1.86e-31	151	388	2	233	Hyaluronan synthases catalyze polymerization of hyaluronan. Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.
cd06423	CESA_like	2.74e-31	153	324	1	168	CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.
COG1215	BcsA	2.57e-26	118	501	23	380	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility].
pfam00535	Glycos_transf_2	7.95e-16	153	322	2	164	Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
pfam13641	Glyco_tranf_2_3	6.57e-15	150	386	3	230	Glycosyltransferase like family 2. Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QQC39714.1	0.0	1	514	1	514
QLF54319.1	0.0	1	514	1	511
BAV84409.1	0.0	1	514	1	513
QQQ59038.1	0.0	1	514	1	510
AMD99051.1	0.0	1	514	1	510

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q8NKX1	6.02e-42	144	511	59	417	Hyaluronan synthase OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) OX=186103 GN=hasA PE=3 SV=1
P0C0H0	6.02e-42	144	511	59	417	Hyaluronan synthase OS=Streptococcus pyogenes OX=1314 GN=hasA PE=3 SV=1
P0C0H1	8.32e-42	144	511	59	417	Hyaluronan synthase OS=Streptococcus pyogenes serotype M1 OX=301447 GN=hasA PE=3 SV=1
P0DB60	1.15e-41	144	511	59	417	Hyaluronan synthase OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) OX=198466 GN=hasA PE=3 SV=1
Q5X9A9	1.15e-41	144	511	59	417	Hyaluronan synthase OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) OX=286636 GN=hasA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000053	0.000001	0.000001	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
5	27
86	108
118	140
415	432
436	458
470	492