dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002699_01079

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Basic Information help

Species

Lineage

Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-74; HGM11588;

CAZyme ID

MGYG000002699_01079

CAZy Family

GH143

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
607	MGYG000002699_16\|CGC1	68567.34	5.6393

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002699	3362623	MAG	Canada	North America

Gene Location

Start: 46283; End: 48106 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002699_01079.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH143	6	561	5.3e-194	0.9838129496402878

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	1.21e-09	252	388	206	339	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	2.39e-07	251	327	168	247	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
cd18625	GH32_BfrA-like	0.009	58	104	6	54	glycoside hydrolase family 32 protein such as Thermotoga maritima invertase (BfrA or Tm1414). This subfamily of glycosyl hydrolase family GH32 includes beta-fructosidase (invertase, EC 3.2.1.26) that cleaves sucrose into fructose and glucose via beta-fructofuranosidase activity, producing invert sugar that is a mixture of dextrorotatory D-glucose and levorotatory D-fructose, thus named invertase. These retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. The breakdown of sucrose is widely used as a carbon or energy source by bacteria, fungi, and plants. Invertase is used commercially in the confectionery industry, since fructose has a sweeter taste than sucrose and a lower tendency to crystallize. A common structural feature of all these enzymes is a 5-bladed beta-propeller domain, similar to GH43, that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACX65304.1	4.42e-185	1	601	1	594
QEL04321.1	5.81e-164	8	607	29	617
ACU59302.1	5.43e-163	6	607	23	613
QXU44071.1	9.86e-163	8	605	26	608
QNR86381.1	2.79e-162	8	605	26	608

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5MQS_A	1.70e-146	4	588	24	594	SialidaseBT_1020 [Bacteroides thetaiotaomicron]
5MQR_A	7.57e-144	4	588	24	594	SialidaseBT_1020 [Bacteroides thetaiotaomicron]

Swiss-Prot Hits help

has no Swissprot hit.

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999786	0.000227	0.000016	0.000001	0.000000	0.000005

TMHMM Annotations help

There is no transmembrane helices in MGYG000002699_01079.