logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000002499_03505

You are here: Home > Sequence: MGYG000002499_03505

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Enterobacter roggenkampii
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Enterobacter; Enterobacter roggenkampii
CAZyme ID MGYG000002499_03505
CAZy Family GH18
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
909 MGYG000002499_11|CGC1 97076.62 4.5845
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002499 4871477 Isolate Singapore Asia
Gene Location Start: 141577;  End: 144306  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 156 549 1.8e-75 0.9493243243243243

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 2.75e-128 159 546 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 1.73e-126 158 546 1 334
Glyco_18 domain.
COG3325 ChiA 3.65e-124 120 563 1 441
Chitinase, GH18 family [Carbohydrate transport and metabolism].
pfam00704 Glyco_hydro_18 4.79e-91 158 546 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 1.74e-67 162 558 4 362
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AOP94923.1 0.0 1 909 1 910
BBV91125.1 0.0 1 909 1 910
AYY04961.1 0.0 1 909 1 910
AYA11010.1 0.0 1 909 1 910
QAZ61985.1 0.0 1 909 1 910

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1EDQ_A 1.71e-268 23 558 1 533
CrystalStructure Of Chitinase A From S. Marcescens At 1.55 Angstroms [Serratia marcescens],1FFQ_A Crystal Structure Of Chitinase A Complexed With Allosamidin [Serratia marcescens]
2WK2_A 1.71e-268 23 558 1 533
ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline dithioamide. [Serratia marcescens]
2WLY_A 2.29e-268 23 558 1 533
ChitinaseA from Serratia marcescens ATCC990 in complex with Chitotrio-thiazoline. [Serratia marcescens],2WLZ_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline. [Serratia marcescens],2WM0_A Chitinase A from Serratia marcescens ATCC990 in complex with Chitobio- thiazoline thioamide. [Serratia marcescens]
1CTN_A 3.43e-268 23 558 1 533
CRYSTALSTRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION [Serratia marcescens]
1EHN_A 4.86e-268 23 558 1 533
ChainA, CHITINASE A [Serratia marcescens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P07254 2.33e-269 2 558 3 556
Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3
P41684 5.99e-214 23 555 17 542
Chitinase OS=Autographa californica nuclear polyhedrosis virus OX=46015 GN=CHIA PE=1 SV=1
O10363 1.49e-211 23 556 16 542
Probable endochitinase OS=Orgyia pseudotsugata multicapsid polyhedrosis virus OX=262177 GN=ORF124 PE=3 SV=1
P32823 4.44e-208 23 858 21 820
Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
P20533 1.60e-63 159 741 46 617
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000317 0.998877 0.000182 0.000216 0.000193 0.000179

TMHMM  Annotations      download full data without filtering help

start end
9 31