dbCAN-seq: a database of CAZyme sequence and annotation

Basic Information help

Species

Salmonella bongori

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella; Salmonella bongori

CAZyme ID

MGYG000002496_03714

CAZy Family

GT20

CAZyme Description

Trehalose-6-phosphate synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
473	MGYG000002496_23\|CGC3	53527.02	6.4393

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002496	4572147	Isolate	Italy	Europe

Gene Location

Start: 64846; End: 66267 Strand: -

Enzyme Prediction help

EC	2.4.1.15

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GT20	4	451	1.9e-166	0.9663157894736842

CDD Domains download full data without filtering help

Cdd ID	Domain	qStart	qEnd	sStart	sEnd	Domain Description
PRK10117	PRK10117	1	473	1	474	trehalose-6-phosphate synthase; Provisional
COG0380	OtsA	1	459	14	486	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism].
TIGR02400	trehalose_OtsA	3	452	1	456	alpha,alpha-trehalose-phosphate synthase [UDP-forming]. This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This model excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This model does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cutoffs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see Wolf, et al., ). [Cellular processes, Adaptations to atypical conditions]
cd03788	GT20_TPS	3	451	1	463	trehalose-6-phosphate synthase. Trehalose-6-Phosphate Synthase (TPS, EC 2.4.1.15) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a nonreducing disaccharide present in a wide variety of organisms and may serve as a source of energy and carbon. It is characterized most notably in insect, plant, and microbial cells. Its production is often associated with a variety of stress conditions, including desiccation, dehydration, heat, cold, and oxidation. This family represents the catalytic domain of the TPS. Some members of this domain family coexist with a C-terminal trehalose phosphatase domain.
pfam00982	Glyco_transf_20	2	452	1	470	Glycosyltransferase family 20. Members of this family belong to glycosyl transferase family 20. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
AID25165.1	1	473	1	473
AGR59263.1	1	473	1	473
QXY85964.1	1	473	1	473
QVP39002.1	1	473	1	473
QQP76770.1	1	473	1	473

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2WTX_A	1.79e-317	1	473	1	474	Insightinto the mechanism of enzymatic glycosyltransfer with retention through the synthesis and analysis of bisubstrate glycomimetics of trehalose-6-phosphate synthase [Escherichia coli K-12],2WTX_B Insight into the mechanism of enzymatic glycosyltransfer with retention through the synthesis and analysis of bisubstrate glycomimetics of trehalose-6-phosphate synthase [Escherichia coli K-12],2WTX_C Insight into the mechanism of enzymatic glycosyltransfer with retention through the synthesis and analysis of bisubstrate glycomimetics of trehalose-6-phosphate synthase [Escherichia coli K-12],2WTX_D Insight into the mechanism of enzymatic glycosyltransfer with retention through the synthesis and analysis of bisubstrate glycomimetics of trehalose-6-phosphate synthase [Escherichia coli K-12]
1UQT_A	2.42e-317	1	473	1	474	Trehalose-6-phosphatefrom E. coli bound with UDP-2-fluoro glucose. [Escherichia coli],1UQT_B Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose. [Escherichia coli],1UQU_A Trehalose-6-phosphate from E. coli bound with UDP-glucose. [Escherichia coli],1UQU_B Trehalose-6-phosphate from E. coli bound with UDP-glucose. [Escherichia coli]
6JAK_A	1.91e-305	2	455	1	455	OtsAapo structure [Escherichia coli],6JAK_B OtsA apo structure [Escherichia coli],6JAK_C OtsA apo structure [Escherichia coli],6JAK_D OtsA apo structure [Escherichia coli]
1GZ5_A	1.55e-302	2	456	1	456	Trehalose-6-phosphatesynthase. OtsA [Escherichia coli],1GZ5_B Trehalose-6-phosphate synthase. OtsA [Escherichia coli],1GZ5_C Trehalose-6-phosphate synthase. OtsA [Escherichia coli],1GZ5_D Trehalose-6-phosphate synthase. OtsA [Escherichia coli]
5V0T_A	4.74e-176	1	453	9	468	Crystalstructure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_B Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_C Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_D Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_E Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_F Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_G Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400],5V0T_H Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia xenovorans in complex with glucose-6-phosphate [Paraburkholderia xenovorans LB400]

Swiss-Prot Hits download full data without filtering help

Hit ID	Query Start	Query End	Hit Start	Hit End	Description
P0CL06	1	473	1	473	Trehalose-6-phosphate synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=otsA PE=3 SV=1
A9MMQ2	1	473	1	473	Trehalose-6-phosphate synthase OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) OX=41514 GN=otsA PE=3 SV=2
A9MU86	1	473	1	473	Trehalose-6-phosphate synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) OX=1016998 GN=otsA PE=3 SV=1
A8AFD4	1	473	1	473	Trehalose-6-phosphate synthase OS=Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) OX=290338 GN=otsA PE=3 SV=2
P0A1Q1	1	473	1	473	Trehalose-6-phosphate synthase OS=Salmonella typhi OX=90370 GN=otsA PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.983702	0.016046	0.000099	0.000058	0.000033	0.000078

TMHMM Annotations help

There is no transmembrane helices in MGYG000002496_03714.

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