CAZyme Information: MGYG000002476_02695

Basic Information

• Species: Yersinia pestis
• Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Yersinia; Yersinia pestis
• CAZyme ID: MGYG000002476_02695
• CAZy Family: GH0
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
497	MGYG000002476_3|CGC23	55417.87	5.6878

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002476	4935125	Isolate	Russia	Europe

• Gene Location: Start: 2828245; End: 2829738 Strand: -

Full Sequence      

MIISPPFLRAKMSSQPDEEWVSSMMPADPQRGYPISNSQAWHGGIHIKHTDHTGVPEQVR
AIADGTVFSVRQPSLQKRDLLPLNYNGPTDCGYVLIKHETEIGSDEGGKVAYWSLYMHMK
SIGSTVSPGSVVYRKDPLGTVGMVDGQNAIHFQIFCDDANIKKLTGRETPELDLANNGRT
DVVYGDIHFYLPAGTPVYDSMPKDNTPVSLMANGPVPRTKSDLFVTMRFHQGSCTMTTLH
KAVFSSMYLEVGEPLTDADGADYEYNLYSKALTLYPNSPSAGYELLRFGRVINTDNETLS
PAGAPLWRTINYPEGKGVVNLAAASVKVFSDADFPHWMGWQLVDDDTDTNSQCNSPTITL
RCKTGVDLSGMICHFPLEWDKTTVDNRFQWLAKENDVLPEPMELCDLGPLTDHAKALCLA
ENPLPSGRVWHFEPTRFIEHFRKCGWLSNKEMKQLIPTKALSNGQWQTIFTIEALHFGKP
VQLLIYREQGSELIIQG

Enzyme Prediction     

No EC number prediction in MGYG000002476_02695.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd12797	M23_peptidase	4.83e-11	42	154	1	85	M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins. This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.
pfam01551	Peptidase_M23	9.40e-07	52	154	3	87	Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.
COG0739	NlpD	1.16e-05	30	154	151	248	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
BCG07675.1	9.53e-216	1	464	1	456
BCG08633.1	6.53e-212	1	465	1	457
VEA07117.1	2.36e-210	1	455	1	447
QQI35182.1	4.52e-209	24	456	1	425
AYW86879.1	1.34e-192	1	462	1	504

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

has no Swissprot hit.

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000066	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002476_02695.