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CAZyme Information: MGYG000002311_01423
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Vibrio cholerae | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Vibrionaceae; Vibrio; Vibrio cholerae | |||||||||||
| CAZyme ID | MGYG000002311_01423 | |||||||||||
| CAZy Family | GH33 | |||||||||||
| CAZyme Description | Sialidase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1612595; End: 1614940 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH33 | 218 | 768 | 8.4e-114 | 0.97953216374269 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG4409 | NanH | 0.0 | 1 | 781 | 27 | 725 | Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis]. |
| pfam09264 | Sial-lect-inser | 8.99e-107 | 347 | 543 | 1 | 198 | Vibrio cholerae sialidase, lectin insertion. Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme. |
| cd15482 | Sialidase_non-viral | 9.27e-32 | 546 | 761 | 145 | 328 | Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases. |
| pfam09264 | Sial-lect-inser | 3.44e-16 | 65 | 215 | 10 | 155 | Vibrio cholerae sialidase, lectin insertion. Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme. |
| pfam13088 | BNR_2 | 1.75e-11 | 546 | 745 | 109 | 272 | BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QTV01065.1 | 0.0 | 1 | 781 | 1 | 781 |
| QHA21694.1 | 0.0 | 1 | 781 | 27 | 807 |
| AVK79103.1 | 0.0 | 1 | 781 | 23 | 803 |
| ARB80595.1 | 0.0 | 1 | 781 | 27 | 807 |
| AVK79105.1 | 0.0 | 1 | 781 | 23 | 803 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1KIT_A | 0.0 | 25 | 781 | 1 | 757 | VibrioCholerae Neuraminidase [Vibrio cholerae],6EKS_A Vibrio cholerae neuraminidase complexed with oseltamivir carboxylate [Vibrio cholerae O1 biovar El Tor str. N16961],6EKU_A Vibrio cholerae neuraminidase complexed with zanamivir [Vibrio cholerae O1 biovar El Tor str. N16961] |
| 1W0O_A | 0.0 | 1 | 781 | 1 | 781 | Vibriocholerae sialidase [Vibrio cholerae],1W0P_A Vibrio cholerae sialidase with alpha-2,6-sialyllactose [Vibrio cholerae] |
| 2W68_A | 2.73e-133 | 25 | 216 | 4 | 195 | EnhancingThe Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae],2W68_B Enhancing The Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae],2W68_C Enhancing The Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A5F7A4 | 0.0 | 1 | 781 | 1 | 781 | Sialidase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) OX=345073 GN=nanH PE=1 SV=2 |
| P0C6E9 | 0.0 | 1 | 781 | 1 | 781 | Sialidase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=nanH PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000303 | 0.998905 | 0.000193 | 0.000228 | 0.000188 | 0.000168 |