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CAZyme Information: MGYG000002306_03221
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Mycobacterium avium | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium avium | |||||||||||
| CAZyme ID | MGYG000002306_03221 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Dimodular nonribosomal peptide synthase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 2883; End: 8162 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK05691 | PRK05691 | 0.0 | 36 | 1309 | 1725 | 3011 | peptide synthase; Validated |
| PRK12467 | PRK12467 | 0.0 | 35 | 1338 | 1112 | 2432 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 42 | 1678 | 52 | 1700 | peptide synthase; Provisional |
| PRK05691 | PRK05691 | 0.0 | 35 | 1692 | 671 | 2329 | peptide synthase; Validated |
| cd05930 | A_NRPS | 0.0 | 505 | 970 | 1 | 444 | The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 1.41e-202 | 78 | 1655 | 599 | 2176 |
| ACX49739.1 | 5.94e-186 | 145 | 1656 | 115 | 1638 |
| BAY90071.1 | 5.28e-139 | 35 | 1051 | 2231 | 3280 |
| BAY30132.1 | 9.46e-139 | 35 | 1051 | 2242 | 3291 |
| AFZ04852.1 | 6.01e-119 | 217 | 1051 | 318 | 1180 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 5U89_A | 2.05e-224 | 489 | 1537 | 22 | 1071 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
| 6P1J_A | 2.05e-151 | 42 | 970 | 8 | 964 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae] |
| 6OYF_A | 6.51e-137 | 42 | 879 | 5 | 873 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module [Eleftheria terrae],6OZV_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with AMP [Eleftheria terrae],6P4U_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg and AMP [Eleftheria terrae] |
| 6P3I_A | 7.42e-134 | 42 | 879 | 5 | 873 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg [Eleftheria terrae] |
| 6MFY_A | 1.32e-132 | 492 | 1655 | 206 | 1326 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P45745 | 2.89e-269 | 46 | 1679 | 15 | 1641 | Dimodular nonribosomal peptide synthase OS=Bacillus subtilis (strain 168) OX=224308 GN=dhbF PE=1 SV=4 |
| O30409 | 6.01e-239 | 42 | 1676 | 1058 | 2661 | Tyrocidine synthase 3 OS=Brevibacillus parabrevis OX=54914 GN=tycC PE=1 SV=1 |
| Q70LM4 | 2.35e-230 | 74 | 1664 | 2615 | 4211 | Linear gramicidin synthase subunit D OS=Brevibacillus parabrevis OX=54914 GN=lgrD PE=1 SV=1 |
| P27206 | 1.35e-222 | 42 | 1647 | 1064 | 2640 | Surfactin synthase subunit 1 OS=Bacillus subtilis (strain 168) OX=224308 GN=srfAA PE=1 SV=4 |
| Q70LM5 | 4.13e-217 | 70 | 1649 | 40 | 1631 | Linear gramicidin synthase subunit C OS=Brevibacillus parabrevis OX=54914 GN=lgrC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000052 | 0.000005 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |